IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O95665 | P30990 | 0 | binding | down-regulates | 0.898 | Neurotensin binding to recombinant neurotensin nt2 receptor expressed in cho cells does not elicit a biological response as determined by second messenger measurements. | SIGNOR-62519 |
P04637 | Q13625 | 0 | binding | up-regulates | 0.898 | 53bp2 interacts with the tumour suppressor p53 and enhances p53-mediated activation of transcription, possibly by facilitating the dephosphorylation of one or more sites on p53 | SIGNOR-114762 |
P21802 | P09038 | 0 | binding | up-regulates | 0.898 | we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2).These structures demonstrate that both mutations introduce additional interactions between FGFR2 and FGF2, thereby augmenting FGFR2-FGF2 affinity. | SIGNOR-86121 |
O14929 | Q16576 | 0 | binding | up-regulates activity | 0.898 | AMPK increased HAT1 activity through phosphorylation of HAT1-Ser190 and RBBP7-Ser314| interaction between RBBP7 and HAT1 is required for acetyltransferase activity | SIGNOR-264786 |
Q15465 | Q96QV1 | 0 | binding | down-regulates activity | 0.897 | Hip encodes a membrane glycoprotein that binds to all three mammalian hedgehog proteins with an affinity comparable to that of ptc-1. our findings support a model in which hip attenuates hedgehog signalling as a result of binding to hedgehog proteins: a negative regulatory feedback loop established in this way could thus modulate the responses to any hedgehog signal. | SIGNOR-65078 |
P35568 | Q06124 | 0 | dephosphorylation | down-regulates | 0.897 | The specific activity of four candidate protein-tyrosine phosphatases (protein-tyrosine phosphatase 1b (ptp1b), sh2 domain-containing ptpase-2 (shp-2), leukocyte common antigen-related (lar), and leukocyte antigen-related phosphatase) (lrp) toward irs-1 dephosphorylation was studied using recombinant proteins in vitro. Ptp1b exhibited the highest specific activity these results provide new insight into novel molecular interactions involving ptp1b and grb2 that may influence the steady-state capacity of irs-1 to function as a phosphotyrosine scaffold and possibly affect the balance of postreceptor insulin signaling. | SIGNOR-74856 |
P14778 | P18510 | 0 | binding | down-regulates activity | 0.897 | Homozygous truncating mutations result in lack of secreted interleukin-1–receptor antagonist protein, which inhibits the proinflammatory cytokines interleukin-1α and interleukin-1β | SIGNOR-262302 |
P54646 | P54619 | 0 | binding | up-regulates | 0.897 | Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. | SIGNOR-139173 |
P00740 | P01008 | 0 | cleavage | down-regulates activity | 0.897 | Antithrombin (AT), a member of the serine protease inhibitor (SERPIN) superfamily, is a major circulating inhibitor of blood coagulation proteases such as factor (F) IIa (known as thrombin), FXa and, to a lesser extent, FIXa, FXIa and FXIIa. SERPINC1, which encodes AT in humans, is located on chromosome 1q25.1 | SIGNOR-264140 |
P24394 | P35225 | 0 | binding | up-regulates activity | 0.896 | IL-4 and IL-13 have overlapping but distinct effects on MFs, dependent on a common IL-4R, with profound changes in the expression of a range of cellular proteins and functions broadly implicated in the regulation of inflammation and repair. | SIGNOR-249528 |
Q04912 | P26927 | 0 | binding | up-regulates | 0.896 | P185ron is a tyrosine kinase activated by msp | SIGNOR-31107 |
Q9Y6Q6 | O14788 | 0 | binding | up-regulates activity | 0.896 | RANKL, a member of the tumour necrosis factor superfamily, is most abundantly expressed as a cell-surface protein by bone-marrow stromal cells. It interacts with its receptor RANK (which is encoded by Tnfrsf11a) on macrophages and mature osteoclasts. | SIGNOR-253042 |
P25963 | O15111 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.896 | We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation | SIGNOR-52875 |
P54756 | P52803 | 0 | binding | up-regulates | 0.896 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor | SIGNOR-52476 |
P22694 | P13861 | 0 | binding | down-regulates activity | 0.896 | Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets | SIGNOR-258757 |
Q13546 | Q12933 | 0 | ubiquitination | up-regulates activity | 0.895 | Following binding to tradd, traf2 was thought to mediate non-degradative lys-63-linked polyubiquitination of rip1 via its ring e3 ligase domain. Rip1 is known to directly interact with traf2. | SIGNOR-59689 |
O43292 | Q96S52 | 0 | binding | up-regulates activity | 0.895 | To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1 and GPI8, and that PIG-T maintains the complex by stabilizing the expression of GAA1 and GPI8. | SIGNOR-261361 |
P11142 | Q99933 | 0 | binding | up-regulates activity | 0.895 | Heat shock cognate protein 70 (Hsc70) regulates protein homeostasis through its reversible interactions with client proteins. Hsc70 has two major domains: a nucleotide-binding domain (NBD), that hydrolyzes ATP, and a substrate-binding domain (SBD), where clients are bound. Members of the BAG family of co-chaperones, including Bag1 and Bag3, are known to accelerate release of both ADP and client from Hsc70. | SIGNOR-254115 |
P19447 | P50613 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.895 | These results led us to propose a model that spironolactone may trigger the phosphorylation of XPB at Ser90 by CDK7, which promotes the recognition and polyubiquitination of XPB by SCFFBXL18 for proteasomal degradation. | SIGNOR-277433 |
P22694 | P31323 | 0 | binding | down-regulates activity | 0.894 | Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets | SIGNOR-258758 |
P31749 | P67775 | 0 | dephosphorylation | down-regulates activity | 0.893 | Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes | SIGNOR-252614 |
P21802 | O15520 | 0 | binding | up-regulates | 0.893 | Rfgf-10 bound the kgfr with high affinity comparable to that of kgf | SIGNOR-57380 |
P61586 | Q9NRY4 | 0 | gtpase-activating protein | down-regulates activity | 0.893 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). | SIGNOR-260492 |
O43318 | Q9Y4K3 | 0 | ubiquitination | up-regulates activity | 0.893 | Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation. Our data show that TGF-beta specifically activates TAK1 through interaction of TbetaRI with TRAF6, whereas activation of Smad2 is not dependent on TRAF6. | SIGNOR-236071 |
Q8N6P7 | Q9GZX6 | 0 | binding | up-regulates | 0.893 | In addition, il-22 mediates inflammation and binds class ii cytokine receptor heterodimers il-22 ra1/crf2-4. | SIGNOR-86340 |
P01112 | Q07889 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.892 | The enhancement of H-Ras GTP levels induced by oncogenic K-Ras was abrogated when the expression of endogenous Sos was suppressed, implicating Sos as an essential intermediate in the cross talk between oncogenic K-Ras and WT H-Ras. | SIGNOR-59472 |
P00533 | O14944 | 0 | binding | up-regulates | 0.892 | Chemical cross-linking experiments showed that [125i]epiregulin directly bound to each of egfr and erbb-4 but not to erbb-2 and erbb-3. remarkably, three members of the epidermal growth factor (egf) family (ereg, areg, and epgn) showed increased expression that was associated with elevated epidermal activation of the egf receptor (egfr) and stat3, a downstream effector of egfr signaling. | SIGNOR-54351 |
Q03405 | P00749 | 0 | binding | up-regulates | 0.891 | The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. | SIGNOR-144306 |
Q04206 | P25963 | 0 | binding | up-regulates activity | 0.891 | Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b. | SIGNOR-17691 |
P36894 | P12644 | 0 | binding | up-regulates | 0.891 | BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). | SIGNOR-253548 |
P62714 | P30153 | 0 | binding | up-regulates | 0.891 | Pr65/a acts as a scaffold protein for binding pp2ac and regulatory b subunits in a heterotrimeric holoenzyme | SIGNOR-138886 |
P05198 | Q9BQI3 | 0 | phosphorylation | down-regulates activity | 0.89 | HRI is an intracellular heme sensor that coordinates heme and globin synthesis in erythropoiesis by inhibiting protein synthesis of globins and heme biosynthetic enzymes during heme deficiency. HRI is a heme-regulated kinase that phosphorylates the α-subunit of eIF2 in heme deficiency, impairing another round of translational initiation and thereby inhibiting translation. | SIGNOR-251817 |
P08069 | P01308 | 0 | binding | up-regulates | 0.89 | Because of the sequence homology and tertiary structure similarities between proinsulin (pi) and insulin-like growth factor-i (igf-i), it is possible that pi interacts with the igf-i receptor with higher affinity than insulin. | SIGNOR-22083 |
O00628 | O75381 | 0 | binding | up-regulates activity | 0.89 | The peroxisomal docking complex is a key component of the import machinery for matrix proteins. The core protein of this complex, Pex14, is thought to represent the initial docking site for the import receptors Pex5 and Pex7. | SIGNOR-253028 |
P10071 | Q9UMX1 | 0 | binding | up-regulates quantity by stabilization | 0.889 | We show that loss of suppressor of fused (Sufu; an inhibitory effector for Gli proteins) results in destabilization of Gli2 and Gli3 full-length activators but not of their C-terminally processed repressors, whereas overexpression of Sufu stabilizes them. | SIGNOR-268868 |
P21333 | Q8WUP2 | 0 | binding | up-regulates activity | 0.888 | Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. | SIGNOR-266105 |
P26951 | P08700 | 0 | binding | up-regulates | 0.888 | The results demonstrate that both the association and dissociation rates for the binding of il-3 to the il-3ralpha are altered by truncation and by amino acid substitution at individual sites. Intracellular signaling studies using k116w and e43n demonstrate that differences in the il-3alpha binding characteristics are reflected in magnitude and kinetics of stat5 phosphorylation. | SIGNOR-111404 |
P05412 | P53779 | 0 | phosphorylation | up-regulates | 0.887 | With epidermal growth factor treatment, overexpression of erk8 in jb6 cl41 cells caused an increased phosphorylation of c-jun at ser(63) and ser(73), resulting in increased activator protein-1 transactivation. | SIGNOR-164800 |
P25116 | P00734 | 0 | cleavage | up-regulates | 0.887 | The par1 receptor subtype is activated when the n terminus is proteolytically cleaved by the serine protease thrombin, resulting in an irreversible activation of the receptor. Thrombin activates platelets by binding and cleaving protease-activated receptors 1 and 4 (par1 and par4). | SIGNOR-199007 |
P16066 | P01160 | 0 | binding | up-regulates | 0.887 | Natriuretic peptide receptor-a (npra) is the biological receptor of the peptide hormones atrial natriuretic peptide (anp) and brain natriuretic peptide (bnp) | SIGNOR-137600 |
P62330 | Q99418 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.887 | Effects of ARNO upon Axonogenesis Are Mediated by Downstream Activation of ARF6. ARNO/ARF6 signaling pathways that could modulate actin reorganization in the axonal growth cone. ARNO stimulates GTP exchange on ARF6, thereby increasing the amount of active ARF6. | SIGNOR-264910 |
P17612 | P10644 | 0 | binding | down-regulates activity | 0.886 | Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets | SIGNOR-258751 |
Q14204 | P43034 | 0 | binding | up-regulates activity | 0.886 | We demonstrate that LIS1 directly interacts with the cytoplasmic dynein heavy chain (CDHC) and NUDEL. LIS1 specifically binds the P1 loop domain of CDHC, while NUDEL binds the C-terminal region as well as a distinct binding site in the P1 loop domain. LIS1 and NUDEL regulate CDHC localization and motor function. Reduction of LIS1 leads to mislocalization of NUDEL, CDHC, β-tubulin, and the Golgi complex | SIGNOR-252158 |
Q04206 | O14920 | 0 | phosphorylation | up-regulates activity | 0.886 | Rela is phosphorylated at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k). We now present evidence that suggests that the upstream kinase ikkbeta plays an important role in tax-induced p53 inhibition through phosphorylation of p65/rela at ser-536. Ikkbeta plays an important role in tax-induced p53 inhibition through phosphorylation of p65/rela at ser-536. | SIGNOR-138903 |
P15260 | P01579 | 0 | binding | up-regulates | 0.886 | Ifn-g Binds to the ifn-g Receptor binding subunit (ifn-gR1;receptor chain 1), a species-specific cell surface transmembrane receptor chain (41, 42). A second transmembrane protein (ifn-gR2) (4345) is required for signal transduction | SIGNOR-95626 |
Q13485 | P12757 | 0 | binding | down-regulates activity | 0.886 | Thus, SnoN can interact with Smad4 and Smad2 and inhibit their abilities to activate transcription. | SIGNOR-71633 |
P41182 | Q6W2J9 | 0 | binding | up-regulates activity | 0.886 | In this study we have shown that BCoR interacts with BCL-6 and potentiates transcriptional repression by BCL-6 with striking specificity. | SIGNOR-252235 |
Q13177 | P60953 | 0 | binding | up-regulates activity | 0.885 | A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. | SIGNOR-248253 |
P36888 | P49771 | 0 | binding | up-regulates | 0.885 | Flt3 ligand (fl) is an early-acting potent co-stimulatory cytokine that regulates proliferation and differentiation of a number of blood cell lineages. Its receptor flt3/flk2 belongs to class iii receptor tyrosine kinases that also include the receptors for colony-stimulating factor 1 | SIGNOR-65564 |
Q15562 | P46937 | 0 | binding | up-regulates | 0.884 | When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. | SIGNOR-201468 |
P06400 | P24941 | 0 | phosphorylation | down-regulates | 0.884 | We demonstrate that phosphorylation by either cdk2-cyclin a, which phosphorylates t821, or cdk4-cyclin d1, which phosphorylates threonine 826, can disable prb for subsequent binding of an lxcxe protein. | SIGNOR-47895 |
P05412 | P45984 | 0 | binding | up-regulates | 0.884 | C-jun is targeted for ubiquitination by its association with inactive c-jun nh2-terminal kinase (jnk).Phosphorylation By activated jnk protects c-jun from ubiquitination. | SIGNOR-53791 |
Q9BUN8 | P55072 | 0 | binding | up-regulates activity | 0.884 | VIMP mediates p97 binding to hDerlin-1. these data suggest that Derlin-1 and VIMP form a membrane protein complex that serves as a receptor for p97. | SIGNOR-261372 |
P54753 | P52799 | 0 | binding | up-regulates | 0.883 | Lerk-5 is a ligand for both elk and hek and induces receptor phosphorylation | SIGNOR-52583 |
P11142 | O75061 | 0 | relocalization | up-regulates activity | 0.883 | Hsc70, recruited by the J-domain protein auxilin, mediates clathrin uncoating and release of a free vesicle, primed to fuse with a target membrane. | SIGNOR-260719 |
Q01344 | P05113 | 0 | binding | up-regulates | 0.883 | Single chain and wt il5 also had similar binding affinity for soluble il5 receptor alpha chain, the specificity subunit of the il5 receptor, as measured kinetically with an optical biosensor. | SIGNOR-40039 |
P12259 | P00734 | 0 | null | up-regulates activity | 0.882 | Thrombin also activates the cofactors FVIII (to FVIIIa) and FV (to FVa) and activates platelets such that they provide a procoagulant membrane surface to which these proteins then bind | SIGNOR-263530 |
P52948 | P78406 | 0 | binding | up-regulates activity | 0.882 | Nup98 is a major interacting partner of Rae1 and known to beinvolved in mRNA export. | SIGNOR-260868 |
Q9UM47 | Q96JK9 | 0 | binding | up-regulates | 0.881 | We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. | SIGNOR-94100 |
Q9NV31 | O00566 | 0 | binding | up-regulates activity | 0.881 | Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome. In eukaryotes, ribosome assembly is a highly complex process that involves more than 200 assembly factors that ensure the folding, modification and processing of the different rRNA species as well as the timely association of ribosomal proteins. One of these factors, Mpp10 associates with Imp3 and Imp4 to form a complex that is essential for the normal production of the 18S rRNA. | SIGNOR-261173 |
P06493 | P38936 | 0 | binding | down-regulates | 0.881 | P21 and p27 are key inhibitors of both cdk1 and cdk2. | SIGNOR-128442 |
P22694 | P31321 | 0 | binding | down-regulates activity | 0.881 | Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets | SIGNOR-258756 |
Q8NEB9 | Q6ZNE5 | 0 | binding | up-regulates activity | 0.881 | Characterization of the new proteins revealed that atg14l enhances vps34 lipid kinase activity and upregulates autophagy, | SIGNOR-235448 |
P25101 | P05305 | 0 | binding | up-regulates | 0.881 | Endothelin-1 (et-1) and angiotensin ii (angii), two potent vasoactive peptides involved in the regulation of cardiovascular homeostasis, also induce mitogenic and pro-angiogenic responses in vitro and in vivo. Both peptides are produced by cleavage of inactive precursors by metalloproteases (endothelin-converting enzyme and angiotensin-converting enzyme, respectively) and activate two subtypes of membrane receptors (eta-r and etb-r for et-1, at1r and at2r for angii) that all belong to the superfamily of g-protein coupled receptors. | SIGNOR-145759 |
Q07890 | P62993 | 0 | binding | up-regulates | 0.88 | Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. | SIGNOR-175180 |
Q00534 | P42773 | 0 | binding | down-regulates | 0.88 | The first group, including p16ink4a, p15ink4b,p18ink4cand p19ink4d, is specific for the g1 cdks,cdk4and cdk6, inhibiting the kinase activity of cyclin d/cdk4-cdk6 complexes on prb. | SIGNOR-44601 |
Q2NKX8 | P53350 | 0 | relocalization | up-regulates | 0.88 | Human pich was identified as an interaction partner and substrate of plk1. Our data indicate that plk1 prevents the association of pich with chromosome arms and restricts its localization to the kt/centromere region | SIGNOR-152136 |
P11802 | P42772 | 0 | binding | down-regulates | 0.879 | We present evidence that the different subcellular location of p15 and p27 ensures the prior access of p15 to cdk4. In the cell, p15 is localized mostly in the cytoplasm, whereas p27 is nuclear. p15 prevails over p27 or a p27 construct consisting of the cdk inhibitory domain tagged with a nuclear localization signal. However, when p15 and p27 are forced to reside in the same subcellular location, either the cytoplasm or the nucleus, p15 no longer prevents p27 from binding to cdk4. These properties allow p15 and p27 to coordinately inhibit cdk4 and cdk2. | SIGNOR-46758 |
P40763 | P00533 | 0 | phosphorylation | up-regulates activity | 0.879 | The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation. | SIGNOR-121965 |
Q9BQQ3 | Q08379 | 0 | binding | up-regulates quantity by stabilization | 0.879 | Previous studies have implicated the GM130–GRASP65 complex in diverse Golgi functions. Therefore, GM130–GRASP65 interactions are required for Golgi ribbon formation.|A surprising clue came from the observation that GM130 was required for stability of GRASP65. | SIGNOR-260601 |
P55957 | Q14790 | 0 | cleavage | up-regulates activity | 0.879 | Caspase-8 cleaves bid at aspartic acid residue 60 (asp60) cleavage of bid by casp8 releases its potent proapoptotic activity | SIGNOR-59655 |
P55211 | P99999 | 0 | binding | up-regulates activity | 0.879 | Caspase-9 and apaf-1 bind to each other via their respective nh2-terminal ced-3 homologous domains in the presence of cytochrome c and datp, an event that leads to caspase-9 activation. | SIGNOR-53585 |
P15056 | P01112 | 0 | binding | up-regulates activity | 0.878 | The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases. | SIGNOR-147327 |
P01024 | P05156 | 0 | cleavage | down-regulates activity | 0.878 | FH also serves as cofactor for the serine protease factor I (FI) that cleaves C3b into iC3b, unable to form C3 convertase (Fig 1B). | SIGNOR-263489 |
Q8WXE1 | Q13535 | 0 | phosphorylation | up-regulates | 0.878 | When dna is damaged, the atr-atrip complex is recruited to chromatin and is activated to transduce the checkpoint signal, but the precise kinase activation mechanism remains unknown. Here, we show that atrip is phosphorylated in an atr-dependent manner after genotoxic stimuli. The serine 68 and 72 residues are important for the phosphorylation in vivo and are required exclusively for direct modification by atr in vitro. | SIGNOR-129473 |
P27930 | P01584 | 0 | binding | down-regulates | 0.878 | Interleukin-1 (il-1) interacts with cells through two types of binding molecules, il-1 type i receptor (il-1r i) and il-1r ii. Il-1r ii inhibits il-1 activity by acting as a decoy target for il-1 | SIGNOR-38302 |
O94817 | Q9H0Y0 | 0 | binding | up-regulates | 0.878 | Analogous to ubiquitination, atg12 is conjugated to atg5 by atg7--an e1-like protein--and atg10--an e2-like protein. | SIGNOR-180129 |
P20042 | Q13144 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.877 | EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. | SIGNOR-269128 |
P41586 | P18509 | 0 | binding | up-regulates | 0.877 | Type i pacap receptors bind pacap-27 and -38. the potencies of the two forms of pacap are similar for adenylate cyclase stimulation, whereas pacap-38 is more potent than pacap-27 in phospholipase c activation. | SIGNOR-43225 |
P29474 | P31749 | 0 | phosphorylation | up-regulates | 0.877 | Recently many investigators have shown that protein phosphorylation of enos by several serine/threonine kinases is a critical control step for no production by endothelial cells. Phosphorylation by amp kinase, akt (or protein kinase b), or protein kinase a on serine 1179 (bovine) or serine 1177 (human) of enos leads to enhanced activity of the enzyme and, thus, augmented production of no. | SIGNOR-112363 |
O75531 | Q99986 | 0 | phosphorylation | down-regulates | 0.877 | We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell | SIGNOR-144783 |
P00742 | P01008 | 0 | cleavage | down-regulates activity | 0.877 | Antithrombin (AT), a member of the serine protease inhibitor (SERPIN) superfamily, is a major circulating inhibitor of blood coagulation proteases such as factor (F) IIa (known as thrombin), FXa and, to a lesser extent, FIXa, FXIa and FXIIa. SERPINC1, which encodes AT in humans, is located on chromosome 1q25.1 | SIGNOR-264138 |
Q96JK9 | Q06330 | 0 | binding | up-regulates | 0.877 | When bound to the active intracellular domain of notch (nicd), rbpj recruits a coactivator complex, including a mastermind homologue (maml1-3 in mammals), and drives a complex transcriptional program with pervasive phenotypic effects. | SIGNOR-176200 |
P38936 | P04637 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.876 | The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line. The WAF1 gene was localized to chromosome 6p21.2, and its sequence, structure, and activation by p53 was conserved in rodents. | SIGNOR-37145 |
P48546 | P09681 | 0 | binding | up-regulates activity | 0.876 | GLP-1 and GIP exert their physiological actions via stimulation of the two G protein-coupled receptors (GPCRs): the GLP-1 receptor (GLP-1R) and the GIP receptor (GIPR), respectively. | SIGNOR-278134 |
P17612 | P13861 | 0 | binding | down-regulates activity | 0.876 | Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets | SIGNOR-258752 |
P19235 | P01588 | 0 | binding | up-regulates | 0.876 | Binding of erythropoietin (epo) to the epo receptor (epor) initiates a signaling cascade resulting in tyrosine phosphorylation of several proteins and induction of ap-1 transcription factor(s). | SIGNOR-55300 |
Q9NRM7 | Q7L9L4 | 0 | binding | up-regulates | 0.876 | Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. | SIGNOR-169798 |
P15056 | P01116 | 0 | binding | up-regulates activity | 0.876 | The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases. | SIGNOR-156906 |
Q06330 | Q92585 | 0 | binding | up-regulates | 0.875 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes0 | SIGNOR-84919 |
P21452 | P20366 | 0 | binding | up-regulates | 0.874 | The mammalian tachykinins include substance p, neurokinin a and neurokinin b, which exert their effects by binding to specific receptors. These tachykinin receptors are divided into three types, designated nk1, nk2 and nk3, respectively. The interaction of tachykinin with its receptor activates gq, which in turn activates phospholipase c to break down phosphatidyl inositol bisphosphate into inositol trisphosphate (ip3) and diacylglycerol (dag). | SIGNOR-44773 |
Q12888 | Q13315 | 0 | phosphorylation | up-regulates | 0.873 | Here we report phosphorylation of 53bp1 at several novel residues, using mass spectrometry and phospho-specific antibodies, and show that ionising radiation-stimulated phosphorylation of these residues requires atm. | SIGNOR-197615 |
Q8IU57 | Q8IU54 | 0 | binding | up-regulates | 0.873 | Il-28 and il-29 interacted with a heterodimeric class ii cytokine receptor that consisted of il-10 receptor beta (il-10rbeta) and an orphan class ii receptor chain, designated il-28ralpha. | SIGNOR-96174 |
P60520 | Q9NT62 | 0 | binding | up-regulates activity | 0.873 | Three human atg8 (hatg8) homologs, lc3, gabarap, and gate-16, have been characterized as modifiers in reactions mediated by hatg7 (an e1-like enzyme) and hatg3 (an e2-like enzyme) | SIGNOR-141926 |
Q13480 | P62993 | 0 | binding | up-regulates | 0.873 | The gab1 docking protein forms a platform for the assembly of a multiprotein signaling complex downstream from receptor tyrosine kinases. In general, recruitment of gab1 occurs indirectly, via the adapter protein grb2 | SIGNOR-235917 |
Q9GZQ8 | O95352 | 0 | binding | up-regulates | 0.873 | These results indicated that the fap motif of atg7 is indispensable for formation of the atg3-lc3 e2-substrate intermediate through the interaction of atg7 with atg3. | SIGNOR-195239 |
P35222 | Q9Y297 | 0 | ubiquitination | down-regulates | 0.872 | Here we show that fwd1 (the mouse homologue of slimb/betatrcp), an f-box/wd40-repeat protein, specifically formed a multi-molecular complex with beta-catenin, axin, gsk-3beta and apc. Mutations at the signal-induced phosphorylation site of beta-catenin inhibited its association with fwd1. Fwd1 facilitated ubiquitination and promoted degradation of beta-catenin, resulting in reduced cytoplasmic beta-catenin levels. | SIGNOR-67374 |
P21860 | Q02297 | 0 | binding | up-regulates | 0.872 | The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3. | SIGNOR-26878 |
Q16763 | Q12834 | 0 | binding | up-regulates activity | 0.872 | Ube2S depends on the cell cycle-dependent association with the APC/C activators Cdc20 and Cdh1 for its activity | SIGNOR-265082 |
Q9H492 | O95352 | 0 | binding | up-regulates | 0.872 | Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe | SIGNOR-195236 |
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