IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P29317 | O43921 | 0 | binding | up-regulates | 0.816 | Ephrin-a ligands (named ephrin-a1_ephrin-a5) are anchored in the plasma membrane through a gpi-linkage, and each can bind any of the epha subclass of receptors (epha1_epha8) | SIGNOR-65413 |
P35638 | P18848 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.816 | ATF4 also induces another bZIP protein C/EBP-homologous protein (CHOP), which is responsible for triggering apoptosis in cells under prolonged ER stress. ATF4 and CHOP further induce growth arrest and DNA damage–inducible protein 34 (GADD34),a regulatory subunit of protein phosphatase 1 (PP1) that dephosphorylates eIF2α. This negative feedback mechanism enables protein synthesis to resume after resolution of ER stress. | SIGNOR-260170 |
P27037 | P08476 | 0 | binding | up-regulates activity | 0.815 | A protein of 494 amino acids comprising a ligand-binding extracellular domain, a single membrane-spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity. 125I-activin A binds to transfected COS cells with an affinity of 180 pM and can be competed by activin A, activin B, and inhibin A, but not by transforming growth factor beta 1. | SIGNOR-235138 |
Q9Y6K9 | O43318 | 0 | binding | up-regulates activity | 0.815 | This result suggests that ikkgamma/nemo binds to the polyubiquitinated tak1. | SIGNOR-162634 |
O43592 | P62826 | 0 | binding | up-regulates activity | 0.815 | The first step in export appears to be the formation of a trimeric tRNA/exportin-t/RanGTP complex. tRNA and RanGTP bind to exportin-t in a highly cooperative manner: tRNA increases the affinity of exportin-t for RanGTP apparently 300-fold (Figure 5A); conversely, RanGTP has to increase the affinity of exportin-t for tRNA by the same factor. RanGTP appears to have at least two functions in this complex. First, it stabilizes the tRNA/exportin-t interaction (see Figure 4B). Second, exportin-t apparently has to bind RanGTP for rapid exit from the nucleus | SIGNOR-261392 |
O14746 | O60832 | 0 | binding | up-regulates activity | 0.815 | Dyskerin was recently found to be associated with active human telomerase (34), and mutations in dyskerin or NOP10 or deletion of the H/ACA motif of hTERC result in diminished telomerase activity | SIGNOR-263332 |
Q13535 | Q92547 | 0 | binding | up-regulates activity | 0.814 | These results establish that TopBP1 can activate both Xenopus and human ATR. Furthermore, these experiments provide conclusive evidence that the kinase activity that is induced by TopBP1 is intrinsic to the ATR protein itself and is not due to a kinase that associates with ATR. | SIGNOR-263232 |
P23528 | P53667 | 0 | phosphorylation | down-regulates | 0.814 | Our results suggest that limk1-mediated cofilin phosphorylation is required for accurate spindle orientation by stabilizing cortical actin networks during mitosis | SIGNOR-159885 |
P29317 | P52797 | 0 | binding | up-regulates | 0.814 | The eph family of receptors. | SIGNOR-52309 |
P12644 | Q13253 | 0 | binding | down-regulates | 0.814 | Noggin acts by binding bmps, thus preventing them from binding to their receptors (180). Noggin binds with various degrees of affinity bmp-2, -4, -5, -6, and -7, gdf-5, gdf-6, and vg1, but not other members of the tgf- family of peptides | SIGNOR-100660 |
Q7Z434 | Q9BYX4 | 0 | binding | up-regulates activity | 0.814 | Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ. | SIGNOR-260140 |
P48357 | P41159 | 0 | binding | up-regulates | 0.814 | Both ob-ra and ob-rb bind leptin with the same affinity, whereas only ob-rb can elicit intracellular response | SIGNOR-55656 |
Q16236 | Q14145 | 0 | ubiquitination | down-regulates quantity | 0.813 | Keap1 is a substrate receptor of a Cul3-RING ubiquitin ligase (CRL3) that, in physiological conditions, constitutively binds and targets Nrf2 for degradation | SIGNOR-259335 |
P49736 | Q9H211 | 0 | binding | up-regulates activity | 0.813 | Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin through the action of Cdc6 and Cdt1. | SIGNOR-261681 |
P27986 | P35568 | 0 | binding | up-regulates activity | 0.813 | Phosphorylated irs then acts as docking site to recruit and activate phosphatidylinositol-3-kinase (pi3k) which phosphorylates membrane phospholipids, generating phosphoinositide-3,4,5-triphosphate (pip3) from phosphoinositide-4,5-biphosphate (pip2). | SIGNOR-175668 |
Q8NHV4 | Q7Z4H7 | 0 | binding | up-regulates activity | 0.813 | FAM29A recruits NEDD1 to spindle MTs. Ectopically expressed NEDD1 and FAM29A interact with each other. | SIGNOR-261421 |
P32241 | P18509 | 0 | binding | up-regulates | 0.813 | Pacap binds to a pacap-specific receptor (pac1) and to vpac receptors (vpac1 and vpac2), which share high affinity for vasoactive intestinal polypeptide (vip). | SIGNOR-116066 |
P01112 | P21359 | 0 | gtpase-activating protein | down-regulates activity | 0.813 | Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation | SIGNOR-204357 |
Q13315 | Q92878 | 0 | binding | up-regulates | 0.813 | One of the earliest events is recruitment and activation of the atm at the damaged dna sites through the mre11rad50nbs1 (mrn) sensor complex. . the mre11/rad50/nbs1 (mrn) complex maintains genomic stability by bridging dna ends and initiating dna damage signaling through activation of the atm kinase. | SIGNOR-175053 |
P19235 | O60674 | 0 | phosphorylation | up-regulates activity | 0.812 | JAK2 in turn phosphorylates several tyrosine residues on the EpoR-cytosolic domain and probably on JAK2 itself that serve as docking sites for SH2 or protein tyrosine binding domains of downstream signal transduction proteins such as STAT5, phosphatidylinositol 3-kinase, Shc, and tyrosine phosphatases SHP1 and SHP2 | SIGNOR-251351 |
Q99661 | P53350 | 0 | phosphorylation | up-regulates activity | 0.812 | Active PLK1, in turn, phosphorylates MCAK at Ser715 which promotes its microtubule depolymerase activity essential for faithful chromosome segregation. | SIGNOR-276931 |
P51587 | Q9BXW9 | 0 | binding | up-regulates activity | 0.812 | Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction | SIGNOR-263238 |
P22681 | P06241 | 0 | phosphorylation | up-regulates activity | 0.812 | Fyn associates with cbl and phosphorylates tyrosine 731 in cbl, a binding site for phosphatidylinositol 3-kinasecbl represents a substrate for src-like kinases that are activated in response to the engagement of cell surface receptors, and that src-like kinases are responsible for the phosphorylation of a tyrosine residue in cbl that may regulate activation of phosphatidylinositol 3-kinase | SIGNOR-63968 |
P50570 | Q9Y5X1 | 0 | binding | up-regulates | 0.812 | Snx9 binds directly to bothdynamin-1 anddynamin-2. Moreover by stimulatingdynaminassembly, snx9 stimulatesdynamin's basal gtpase activity and potentiates assembly-stimulated gtpase activity on liposomes. | SIGNOR-133976 |
P84022 | P36897 | 0 | phosphorylation | up-regulates activity | 0.812 | A major event leading to Smad3 activation is the TGF-beta-induced, TbetaRI-mediated phosphorylation at two C-terminal serine residues, Ser-423 and Ser-425, which triggers dissociation of Smad3 from its receptors to form a complex with Smad4 and accumulate in the nucleus | SIGNOR-235380 |
Q15375 | P20827 | 0 | binding | up-regulates | 0.812 | The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions | SIGNOR-56965 |
P60953 | P46940 | 0 | binding | down-regulates activity | 0.811 | Although the name implies that it functions as a GTPase-activating protein, IQGAP1 actually stabilizes Cdc42 and Rac1 in the active, GTP-bound form (5, 8, 17). Thus, IQGAP1 acts as an “anti-GTPase-activating protein” for Cdc42 and Rac1, with marked effects on the cytoskeleton. | SIGNOR-261888 |
P54756 | P52798 | 0 | binding | up-regulates | 0.811 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor | SIGNOR-52430 |
P63000 | P52565 | 0 | guanine nucleotide exchange factor | down-regulates activity | 0.811 | Here, we report the expression of plexin-B3 in glioma cells, which upon stimulation by its ligand Sema5A results in significant inhibition of cell migration and invasion. A search for the underlying mechanism revealed direct interaction of plexin-B3 with RhoGDP dissociation inhibitor α (RhoGDIα), a negative regulator of RhoGTPases that blocks guanine nucleotide exchange and sequesters them away from the plasma membrane. direct interaction of RhoGDIα and the cytoplasmic domain of plexin-B3 (plexin-B3CD) was confirmed by GST pulldown assays.RhoGDIα is required for Sema5A-induced Rac1 inactivation and inhibition of cell invasion in C6 glioma. | SIGNOR-268436 |
P61224 | Q8WZA2 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.811 | Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. | SIGNOR-263955 |
Q00987 | P31749 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.811 | Mitogen-induced activation of phosphatidylinositol 3-kinase (pi3-kinase) and its downstream target, the akt/pkb serine-threonine kinase, results in phosphorylation of mdm2 on serine 166 and serine 186. Phosphorylation on these sites is necessary for translocation of mdm2 from the cytoplasm into the nucleus.Both akt expression and serum treatment induced phosphorylation of mdm2 at ser186. | SIGNOR-116270 |
P42229 | Q15303 | 0 | phosphorylation | up-regulates activity | 0.811 | ERBB4 directly activates STAT5A, in part, through phosphorylation of STAT5A at the regulatory Tyr-694.|ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. | SIGNOR-279711 |
Q9UF33 | P20827 | 0 | binding | up-regulates | 0.811 | Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm. ephrin-a1 interacts with all the other epha subclass receptors as well, although with different affinity | SIGNOR-56962 |
Q12879 | P78352 | 0 | relocalization | up-regulates activity | 0.811 | The PDZ domains of PSD-95 and related proteins interact with the COOH-terminal sequences of K+channels and NMDA2 receptors (3). By these interactions, PSD-95 may mediate the clustering of K+ channels and NMDA receptors at synapses. | SIGNOR-264194 |
P54756 | P20827 | 0 | binding | up-regulates | 0.811 | Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm. ephrin-a1 interacts with all the other epha subclass receptors as well, although with different affinity | SIGNOR-56910 |
O95140 | Q9BXM7 | 0 | phosphorylation | down-regulates quantity | 0.81 | If PINK1 is responsible for the degradation of Mfn2, then silencing PINK1 should induce mitochondrial fusion by upregulating Mfn2 expression.|We show that downregulation of Mfn2 is induced by proteasomal degradation triggered by PINK1, which phosphorylates Mfn2 at S442. | SIGNOR-278208 |
P27986 | P00533 | 0 | binding | up-regulates | 0.81 | The egf-r coimmunoprecipitated with p85 alpha | SIGNOR-121959 |
Q12778 | Q96EB6 | 0 | deacetylation | down-regulates quantity by destabilization | 0.81 | SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 | SIGNOR-217975 |
Q13464 | P61586 | 0 | binding | up-regulates activity | 0.81 | Planar cell polarity (pcp) signalling triggers activation of the small gtpases rhoa and rac1, which in turn activate rho kinase (rock) and jun-n-terminal kinase (jnk), respectively, leading to actin polymerization and microtubule stabilization. | SIGNOR-199542 |
P12643 | Q13253 | 0 | binding | down-regulates | 0.81 | Noggin acts by binding bmps, thus preventing them from binding to their receptors (180). Noggin binds with various degrees of affinity bmp-2, -4, -5, -6, and -7, gdf-5, gdf-6, and vg1, but not other members of the tgf- family of peptides | SIGNOR-100657 |
P61073 | P48061 | 0 | binding | up-regulates | 0.809 | To study the role of the sdf-1/cxcr4-chemokine/receptor system as a regulator of vertebrate development, we isolated and characterized a cdna encoding sdf-1 of the lower vertebrate xenopus laevis (xsdf-1). Recombinant xsdf-1 was produced in insect cells, purified, and functionally characterized. Although xsdf-1 is only 64-66% identical with its mammalian counterparts, it is indistinguishable from human (h)sdf-1alpha in terms of activating both x. laevis cxcr4 and hcxcr4. Thus, both xsdf-1 and hsdf-1alpha promoted cxcr4-mediated activation of heterotrimeric g(i2) in a cell-free system and induced release of intracellular calcium ions in and chemotaxis of intact lymphoblastic cells. | SIGNOR-115029 |
P04792 | P49137 | 0 | phosphorylation | down-regulates | 0.809 | Notably mk2 is well known to play an important role in actin filament remodellng by phosphorylating hsp27. | SIGNOR-94021 |
Q9Y219 | Q96AX9 | 0 | ubiquitination | up-regulates | 0.809 | Skeletrophin bound the intracellular regions of the notch ligand jagged-2, but not to those of delta-1, -3, -4, or jagged-1. Skeletrophin, but not its ring-mutated form, ubiquitinized the intracellular region of jagged-2. | SIGNOR-137922 |
Q8IZF0 | Q8N2C7 | 0 | binding | up-regulates activity | 0.809 | The NALCN complex in the brain consists of NALCN, UNC80 and UNC79. UNC80 directly associates with NALCN and UNC79 forms part of the complex by its interaction with UNC80. | SIGNOR-265184 |
P15927 | Q13315 | 0 | phosphorylation | up-regulates | 0.809 | Replication protein a (rpa) is a single-stranded dna (ssdna) binding protein involved in various processes, including nucleotide excision repair and dna replication. The 32 kda subunit of rpa (rpa32) is phosphorylated in response to various dna-damaging agents, and two protein kinases, ataxia-telangiectasia mutated (atm) and the dna-dependent protein kinase (dna-pk) have been implicated in dna damage-induced phosphorylation of rpa32we show that both dna-pk and atm phosphorylate rpa32 on thr21 in vitro. | SIGNOR-121861 |
Q8NEB9 | Q9P2Y5 | 0 | binding | up-regulates activity | 0.809 | Although both human atg14 and uvrag interact with beclin 1 and vps34. | SIGNOR-181554 |
P49023 | P12931 | 0 | phosphorylation | up-regulates activity | 0.808 | Here, we demonstrate that Src kinase directly phosphorylates Y88 paxillin|In this study, we also show how pY88 paxillin transduces a signal to activate Akt | SIGNOR-263977 |
P49917 | P78527 | 0 | phosphorylation | down-regulates | 0.808 | Using tandem mass spectrometry, we identified a dna-pk phosphorylation site at thr-650 in human lig4 and a potential second phosphorylation site at ser-668 or ser-672. Phosphorylation of lig4 per se was not required for lig4 dna end joining activity. Substitution of these amino acids with alanine, individually or in combination, led to changes in lig4 protein stability of mouse lig4. The phosphomimetic mutation s650d returned lig4 stability to that of the wild-type protein. Furthermore dna-pk was found to negatively regulate lig4 protein stability. | SIGNOR-125877 |
P35222 | P49768 | 0 | binding | down-regulates | 0.808 | Importantly, our data show that binding of ps1 to cadherin mediates the effects of ps1 on the phosphorylation, ubiquitination, and destabilization of beta-catenin. Thus, cadherins mediate both the association of ps1 and beta-catenin and the effects of ps1 on the cellular levels of beta-catenin | SIGNOR-22837 |
Q04721 | Q92585 | 0 | binding | up-regulates | 0.808 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1. | SIGNOR-84835 |
Q07817 | Q13323 | 0 | binding | down-regulates | 0.808 | We have identified a novel cellular protein, bik, that interacts with the cellular survival-promoting proteins, bcl-2 and bcl-xl in transient transfection assays, bik promotes cell death in a manner similar to the death-promoting members of the bcl-2 family, bax and bak. | SIGNOR-26453 |
Q9BY84 | P28482 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.808 | Phosphorylation of Ser-446 determines stability of MKP-7.|We also determined that MKP-7 phosphorylated at Ser-446 has a longer half-life than unphosphorylated form of the wild type protein, as does a phospho-mimic mutant of MKP-7. These results indicate that activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation. | SIGNOR-249389 |
Q15562 | Q9GZV5 | 0 | binding | up-regulates | 0.808 | When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. | SIGNOR-201382 |
O43157 | Q92854 | 0 | binding | up-regulates | 0.808 | Binding of sema 4d to plexin b1 stimulates the tyrosine kinase activity of met, resulting in tyrosine phosphorylation of both receptors. | SIGNOR-92201 |
Q9HC77 | Q66GS9 | 0 | binding | up-regulates activity | 0.808 | In this study, we demonstrate that the human microcephaly protein, CEP135, directly interacts with hSAS-6 via its carboxyl-terminus and with MTs via its amino-terminus. Unexpectedly, CEP135 also interacts with another microcephaly protein CPAP via its amino terminal domain. Depletion of CEP135 not only perturbed the centriolar localization of CPAP, but also blocked CPAP-induced centriole elongation. We propose that CEP135 may serve as a linker protein that directly connects the central hub protein, hSAS-6, to the outer MTs, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. | SIGNOR-269677 |
P19174 | O43561 | 0 | binding | up-regulates activity | 0.808 | By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) and Tyr(191) are required for Vav binding, whereas Tyr(171) and Tyr(132) are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 respectively. | SIGNOR-246060 |
P14653 | P40424 | 0 | binding | up-regulates activity | 0.807 | Pbx1 and exd act as cofactors that enhance the DNA binding specificity of Hox proteins. The structure of the HoxB1Pbx1DNA ternary complex shows that HoxB1 and Pbx1 bind to overlapping binding sites located on opposite faces of the DNA. | SIGNOR-241219 |
O15534 | P48730 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.807 | Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. We have now extended our previous studies to show that human casein kinase Idelta (hCKIdelta), the closest homologue to hCKIepsilon, associates with and phosphorylates hPER1 and causes protein instability. Furthermore, we observed that both hCKIdelta and hCKIepsilon phosphorylated and caused protein instability of human period 2 protein (hPER2). | SIGNOR-268001 |
P28749 | P11802 | 0 | phosphorylation | up-regulates activity | 0.807 | Here we assessed the effects of alanine substitution at the individual or combined Cdk4(6)-specific sites in p130, compared with homologous sites in p107 (Thr(369)/Ser(650)/Ser(964)). In U-2-OS cells, the triple p107(DeltaCdk4)* mutant strongly inhibited E2F-4 activity and imposed a G(1) arrest resistant to cyclin D1 coexpression. | SIGNOR-250764 |
Q92569 | P08069 | 0 | binding | up-regulates | 0.807 | Moreover, we found that the insulin-like growth factor-1 receptor (igf-ir) bound to p55pik;the interaction occurred at the receptor tyrosine 1316 and involved both p55pik sh2 domains. | SIGNOR-52683 |
P14780 | P01033 | 0 | binding | down-regulates activity | 0.807 | Tissue inhibitor of metalloproteinase (TIMP-1) is an inhibitor of MMP-9 that binds to MMP-9 precursors and to the active form. | SIGNOR-278116 |
Q04771 | P18075 | 0 | binding | up-regulates | 0.807 | Bmp-4 and gdf-5 are known to bind to activin receptor-like kinase 3 (alk-3) and/or alk-6 (also termed bmp type ia and type ib receptors, respectively), whereas bmp-6 and bmp-7 preferentially bind to alk-2 | SIGNOR-236913 |
P29353 | P04626 | 0 | binding | up-regulates | 0.807 | Shc interacts with and is an excellent substrate for erbb2 and appears to play an important role in mitogenic signaling through this receptor tyrosine kinase | SIGNOR-65579 |
P42262 | Q9NRD5 | 0 | binding | up-regulates activity | 0.807 | RAB39B directs GluA2 trafficking in neurons. GTP-bound RAB39B interacts with PICK1. In line with evidence that PICK1 can dimerize, the structural model suggests that dimerization of PICK1 is a prerequisite for simultaneous recognition of both RAB39B and GluA2 each by one of the PICK1 molecules in the PICK1 dimer (Fig. 6a–c). The existence of such complex is supported by our co-immunoprecipitation experiments shown above. | SIGNOR-264046 |
P10242 | Q92793 | 0 | binding | up-regulates activity | 0.807 | the nuclear co-activator CREB binding protein (CBP). This protein interacts directly with both c-Myb and v-Myb and potentiates Myb-specific transcription | SIGNOR-240994 |
Q8WV28 | P43405 | 0 | phosphorylation | up-regulates | 0.806 | The phosphorylation of multiple tyrosine residues not only amplifies plcgamma-mediated signaling but also supports 'cis'-mediated interaction between distinct signaling effectors within a large molecular complex. | SIGNOR-96044 |
P61586 | Q92974 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.806 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). | SIGNOR-260529 |
Q15375 | O43921 | 0 | binding | up-regulates | 0.806 | The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. | SIGNOR-52206 |
P15172 | P15923 | 0 | binding | up-regulates activity | 0.806 | In addition we demonstrate that myod, in conjunction with e12/e47-like proteins, is functioning as a regulatory nodal point for activation of several other downstream muscle regulators. | SIGNOR-20540 |
Q969F8 | Q15726 | 0 | binding | up-regulates | 0.806 | Here we show that kiss-1 (refs 1, 4) encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which we have isolated from human placenta as the endogenous ligand of an orphan g-protein-coupled receptor (hot7t175) and have named 'metastin' | SIGNOR-108480 |
P35222 | O14640 | 0 | binding | up-regulates activity | 0.806 | Activated DVL binds and inhibits the phosphorylation of beta-catenin by GSK3B, blocking beta-catenin degradation so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induces the transcription of target genes such as c-jun, c-myc, and cyclin d1. | SIGNOR-134285 |
P42224 | O60674 | 0 | phosphorylation | up-regulates | 0.806 | Phosphorylation at tyr701 by the janus family of tyrosine kinases (jak) leads to stat1 dimerization via its src homology 2 domains, exposure of a dimer-specific nuclear localization signal, and subsequent nuclear translocation. | SIGNOR-235709 |
Q13043 | Q9NS23 | 0 | binding | up-regulates | 0.806 | Rassf1a and mst1 co-exist as a complex localizing at microtubules throughout the cell cycle, of which the rassf1a mst1 interaction is stimulatory to the mst1 kinase activity. | SIGNOR-197744 |
Q16671 | P03971 | 0 | binding | up-regulates | 0.806 | The results point to anti-m?llerian Hormone (amh) being the most likely candidate ligand for c14. | SIGNOR-36215 |
Q9UDY8 | Q9BXL7 | 0 | binding | up-regulates | 0.805 | The carboxy-terminal part of the bcl10 card and a short stretch of 13 amino acids following the card are required for constitutive binding to malt1. | SIGNOR-167393 |
Q15628 | P19438 | 0 | binding | up-regulates activity | 0.805 | We have identified a novel 34 kda protein, designated tradd, that specifically interacts with an intracellular domain of tnfr1 tradd interacts with the death domain of tnfrsf1a to initiate distinct signaling cascades for two of the most important biological activities of tnf, nf-kb activation and programmed cell death tradd, a novel protein that specifically interacts with the death domain of tnfr1 and activates signaling pathways for both of these activities when overexpressed. | SIGNOR-32739 |
P01130 | P04114 | 0 | binding | up-regulates | 0.805 | In the case of ldl, binding of apolipoprotein b (apob) to the ldl-r18-20 and proteoglycans17 21 initiates plasma clearance and lipoprotein degradation | SIGNOR-87035 |
P84022 | Q96PU5 | 0 | ubiquitination | down-regulates activity | 0.805 | Through its ww domain, nedd4l specifically recognizes a tgf-beta-induced phosphothr-protyr motif in the linker region, resulting in smad2/3 polyubiquitination and degradation | SIGNOR-232104 |
P35222 | P31749 | 0 | phosphorylation | up-regulates | 0.805 | Phosphorylation of beta-catenin by akt promotes beta-catenin transcriptional activity|we have demonstrated that akt phosphorylates beta-catenin at ser552 in vitro and in vivo. | SIGNOR-252499 |
P20336 | Q86UR5 | 0 | relocalization | up-regulates activity | 0.805 | N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle | SIGNOR-264381 |
P51686 | O15444 | 0 | binding | up-regulates | 0.805 | Ccr9 is a specific receptor for the beta-chemokine teck/ccl25. | SIGNOR-104902 |
Q16539 | Q9BY84 | 0 | dephosphorylation | down-regulates | 0.805 | Mkp-7 binds to and inactivates p38 mapk and jnk/sapk, but not erk inhibited by dual specificity phosphatases, such as dusp1, dusp10, and dusp16(uniprot) | SIGNOR-108233 |
P06730 | P11940 | 0 | binding | up-regulates activity | 0.805 | The binding of PABP to mRNA poly(A) tails is followed by interactions with eukaryotic initiation factor (eIF4G) and other translation factors, including eIF4E, to constitute a translation initiation complex, which mediates cellular mRNA circularization and enhances cap-dependent translation by facilitating ribosome recycling | SIGNOR-260968 |
P00751 | P00746 | 0 | cleavage | up-regulates activity | 0.804 | The resulting proconvertase C3bB is subsequently cleaved by factor D (FD), generating the AP C3 convertase C3bBb | SIGNOR-263488 |
Q13873 | P18075 | 0 | binding | up-regulates | 0.804 | In transfected cos-1 cells, osteogenic protein (op)-1/bmp-7, and less efficiently bmp-4, bound to bmpr-ii. Bmpr-ii bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type i receptors for bmps. Binding of op-1/bmp-7 to bmpr-ii was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by bmpr-ii in the presence of type i receptors after stimulation by op-1/bmp-7. | SIGNOR-30512 |
P62993 | O43561 | 0 | binding | up-regulates | 0.804 | Phosphorylated tyrosines 171, 191, and 226 [in LAT] bind to the SH2 domains of the Grb2 family of adaptor proteins and must be present for optimal signalling | SIGNOR-251520 |
Q13094 | P43403 | 0 | phosphorylation | up-regulates | 0.804 | Zap-70 phosphorylates slp-76 at specific sites that allow vav sh2 domain bindingwe also show by in vitro and in vivo analysis that two slp-76 pyesp motifs (y113 and y128) mediate binding, the first being more efficient. | SIGNOR-46859 |
P30307 | P53350 | 0 | phosphorylation | up-regulates | 0.804 | The nuclear accumulation of active m-phase promoting factor (mpf) during prophase is thought to be essential for coordinating m-phase events in vertebrate cells. The protein phosphatase cdc25c, an activator of mpf, enters the nucleus to keep mpf active in the nucleus during prophase. these results suggest that plk1 phosphorylates cdc25c on ser198 and regulates nuclear translocation of cdc25c during prophase. | SIGNOR-115993 |
P29320 | P52797 | 0 | binding | up-regulates | 0.804 | The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. transmembrane ligands for eph receptors also exhibit properties of signal transducing molecules, suggesting that bidirectional signaling occurs when receptor-expressing cells contact ligand-expressing cells. | SIGNOR-52312 |
P56945 | P12931 | 0 | phosphorylation | up-regulates activity | 0.803 | Cas is a member of the focal adhesion complex. Phosphorylation of Cas by Src is an important event leading to cell transformation. Using mass spectrometry, we have mapped 11 sites in Cas that are phosphorylated by Src. These sites are all located between residues 132 and 414 of CasBased on these data, 11 tyrosine residues (132, 169, 183, 196, 238, 253, 271, 291, 301, 391, and 414) were phosphorylated by Src|the biological activity of Cas depends on its phosphorylation by Src (16–18). After phosphorylation, Cas associates with a number of proteins, including Crk, Src, phosphatidylinositol 3-kinase, Nck, and phospholipase Cgamma, via SH2 binding motifs | SIGNOR-246393 |
O95786 | Q14258 | 0 | ubiquitination | up-regulates activity | 0.803 | Lys63 linked polyubiquitination of RIG-I at Lys 172 catalyzed by TRIM25 is an important step for RIG-I activation. | SIGNOR-278730 |
Q9GZQ8 | Q9Y4P1 | 0 | cleavage | up-regulates | 0.803 | Human atg4 homologues cleave the carboxyl termini of the three human atg8 homologues, microtubule-associated protein light chain 3 (lc3), gabarap, and gate-16. | SIGNOR-125449 |
P54274 | O95271 | 0 | ADP-ribosylation | down-regulates activity | 0.803 | Tankyrase 1 ADP-ribosylates TRF1, inhibiting its binding to telomeric DNA. | SIGNOR-263377 |
P62993 | P35568 | 0 | binding | up-regulates activity | 0.803 | Association ofinsulinreceptor substrate 1 (irs-1) y895 with grb-2 mediates theinsulinsignaling involved in irs-1-deficient brown adipocyte mitogenesis. | SIGNOR-236614 |
P78352 | Q9Y2H0 | 0 | binding | up-regulates activity | 0.803 | SAPAPs are specifically expressed in neuronal cells and enriched in the PSD fraction. SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area. | SIGNOR-264212 |
Q9ULT6 | Q2MKA7 | 0 | relocalization | down-regulates quantity | 0.803 | Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3. These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. | SIGNOR-260113 |
P04637 | Q96EB6 | 0 | deacetylation | down-regulates | 0.803 | Sirt1 has been shown to regulate cell fate in part by deacetylating the p53 protein at lysine 382 and inhibiting p53-mediated transcriptional activation and apoptosis. | SIGNOR-182515 |
Q9P2D8 | Q8N2C7 | 0 | binding | up-regulates activity | 0.803 | The NALCN complex in the brain consists of NALCN, UNC80 and UNC79. UNC80 directly associates with NALCN and UNC79 forms part of the complex by its interaction with UNC80. | SIGNOR-265183 |
Q9Y6C5 | Q15465 | 0 | binding | down-regulates activity | 0.803 | Biochemical analysis of ptch and ptch2 shows that they both bind to all hedgehog family members with similar affinity and that they can form a complex with smo.Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. | SIGNOR-217776 |
Q15109 | P09429 | 0 | binding | up-regulates activity | 0.803 | HMGB1 is known to influence cellular responses within the nervous system via two distinct receptor families; the Receptor for Advanced Glycation End-products (RAGE) and Toll-like receptors (TLRs) | SIGNOR-252059 |
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