IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P24941 | Q5MJ70 | 0 | relocalization | up-regulates activity | 0.791 | Speedy/RINGO A, a noncanonical activator of CDK2, was recently identified as a key regulator for CDK2 recruitment to meiotic telomeres | SIGNOR-263310 |
Q9GZV5 | O95835 | 0 | phosphorylation | down-regulates | 0.791 | In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. | SIGNOR-197643 |
Q9Y6C5 | Q14623 | 0 | binding | down-regulates activity | 0.791 | Biochemical analysis of ptch and ptch2 shows that they both bind to all hedgehog family members with similar affinity and that they can form a complex with smo.Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. | SIGNOR-61314 |
P98155 | P78509 | 0 | binding | up-regulates | 0.791 | The hypothesis that the vldl receptor signals in response to reelin binding was recently supported by studies (37) showing direct binding of reelin to the vldl receptor and changes in tyrosine phosphorylation in response to reelin-vldl receptor association. | SIGNOR-106295 |
Q13546 | Q13158 | 0 | binding | up-regulates activity | 0.791 | Rip1 is required for the formation of a rip1/fadd/caspase-8 complex that drives caspase-8 activation, cleavage of bid into tbid, mitochondrial outer membrane permeabilization, full activation of caspase-3 and caspase-dependent apoptosis. Tweak induces assembly of a death-signaling complex containing rip1, fadd, and caspase-8 | SIGNOR-191781 |
P51003 | Q6UN15 | 0 | binding | up-regulates | 0.791 | Recombinant hfip1 is sufficient to stimulate the in vitro polyadenylation activity of pap in a u-rich element-dependent manner. hfip1, cpsf160 and pap form a ternary complex in vitro, suggesting that hfip1 and cpsf160 act together in poly(a) site recognition and in cooperative recruitment of pap to the rna. | SIGNOR-121700 |
P42224 | P23458 | 0 | phosphorylation | up-regulates activity | 0.79 | The central event in cytokine_dependent transcriptional regulation is phosphorylation of STATs on a single tyrosine residue at their C_terminus (Darnell, 1997b). The reaction is catalyzed by cytokine receptor_associated tyrosine kinases of the Janus type (Jak) at the cell membrane and triggers the homo_ and heterodimerization of STAT molecules via reciprocal phosphotyrosineSH2 domain interactions | SIGNOR-236373 |
P40189 | P15018 | 0 | binding | up-regulates | 0.79 | Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.Some Of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2 | SIGNOR-48108 |
O75581 | P56704 | 0 | binding | up-regulates activity | 0.79 | Here, we present evidence that lrp6 is internalized with caveolin and that the components of this endocytic pathway are required not only for wnt-3a-induced internalization of lrp6 but also for accumulation of beta-catenin. | SIGNOR-148671 |
P05412 | P28482 | 0 | phosphorylation | up-regulates activity | 0.79 | Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1. | SIGNOR-201943 |
Q96CW1 | Q2M2I8 | 0 | phosphorylation | up-regulates | 0.79 | Aak1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and ap2 in clathrin-coated pits and at the leading edge of migrating cells. Aak1 specifically phosphorylates the mu subunit in vitro, and stage-specific assays for endocytosis show that mu phosphorylation by aak1 results in a decrease in ap2-stimulated transferrin internalization. Together, these results provide strong evidence that aak1 is the endogenous mu 2 kinase and plays a regulatory role in clathrin-mediated endocytosis. | SIGNOR-115657 |
P13498 | P14598 | 0 | binding | up-regulates activity | 0.79 | Stimulus-induced phosphorylation of p47phox causes a conformational change, by which both PX and SH3 domains become accessible to their membranous targets, phosphoinositides and p22phox, respectively. Cooperation of these two interactions, each being indispensable, enables p47phox to form a stable complex with cytochrome b558 (composed of the two subunit gp91phox and p22phox), leading to activation of the phagocyte NADPH oxidase. | SIGNOR-276625 |
Q9UM47 | Q92585 | 0 | binding | up-regulates | 0.79 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1. | SIGNOR-84838 |
Q13153 | P63000 | 0 | binding | up-regulates activity | 0.79 | A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. | SIGNOR-248236 |
P35222 | O95996 | 0 | relocalization | down-regulates quantity by destabilization | 0.79 | The tumour-suppressing activity of apc largely involves facilitating the proteasome-mediated degradation of b-cateninit is possible that once exported from the nucleus, apc directs b-catenin along the cytoskeletal network to sites of degradation. | SIGNOR-81545 |
P01112 | Q07890 | 0 | guanine nucleotide exchange factor | up-regulates | 0.79 | Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. | SIGNOR-175262 |
Q13501 | Q9H0R8 | 0 | binding | up-regulates activity | 0.79 | P62 binds both to lc3a and -b and the related gabarap family proteins/this interaction is necessary for autophagic degradation of p62-positive cytoplasmic inclusion bodies containing ubiquitinated proteins. We also demonstrate that alis are indistinguisha | SIGNOR-156304 |
Q9BQ95 | Q9Y4K3 | 0 | ubiquitination | down-regulates activity | 0.79 | Here we demonstrate that engagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitochondria to macrophage phagosomes and augments mROS production. This response involves translocation of a TLR signalling adaptor, tumour necrosis factor receptor-associated factor 6 (TRAF6), to mitochondria, where it engages the protein ECSIT (evolutionarily conserved signalling intermediate in Toll pathways), which is implicated in mitochondrial respiratory chain assembly. Interaction with TRAF6 leads to ECSIT ubiquitination and enrichment at the mitochondrial periphery, resulting in increased mitochondrial and cellular ROS generation | SIGNOR-260370 |
P24928 | P50613 | 0 | phosphorylation | down-regulates | 0.789 | Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination. | SIGNOR-120024 |
Q02750 | P15056 | 0 | phosphorylation | up-regulates activity | 0.789 | Activation of mek family kinases requires phosphorylation of two conserved ser/thr residueserine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf. | SIGNOR-235475 |
Q14315 | Q8WUP2 | 0 | binding | up-regulates activity | 0.789 | Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. | SIGNOR-266107 |
P40763 | P12931 | 0 | phosphorylation | up-regulates activity | 0.789 | In the present study, we have delineated the mechanism by which Galpha16 stimulates STAT3 in human embryonic kidney 293 cells. A constitutively active Galpha16 mutant, Galpha16QL, stimulated STAT3-dependent luciferase activity as well as the phosphorylation of STAT3 at both Tyr705 and Ser727.The involvement of tyrosine kinases such as c-Src and Janus kinase 2 and 3 (JAK2 and JAK3) in Galpha16QL-induced activation of STAT3 was illustrated by the combined use of selective inhibitors and dominant negative mutants. | SIGNOR-247341 |
Q9BXW9 | Q13315 | 0 | phosphorylation | up-regulates | 0.789 | These results suggest that s222 and either s1401, s1404, or s1408 are sites of atm-dependent phosphorylation in vitro.Phosphorylation Of fancd2 is required for activation of an s phase checkpoint | SIGNOR-90117 |
P36897 | O15105 | 0 | binding | down-regulates activity | 0.789 | SMAD7 functions as an antagonist to TGFB by binding to the TBRI and thus inhibiting activation of SMAD2 and SMAD3. | SIGNOR-64088 |
Q9Y4K3 | Q9NQC7 | 0 | deubiquitination | down-regulates | 0.789 | The nf-kappab activation by cyld is mediated, at least in part, by the deubiquitination and inactivation of tnfr-associated factor 2 (traf2) and, to a lesser extent, traf6. | SIGNOR-117856 |
P45983 | P28562 | 0 | dephosphorylation | down-regulates | 0.789 | Jnk1 phosphorylation and activation was inhibited by expression of both mkp1 and mkp2. | SIGNOR-46079 |
P62834 | Q9Y4G8 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.789 | Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.Increased intracellular concentrations of cAMP enhanced the Rapgef2-dependent activation of Rap1, which in turn associated with B-Raf to enable the activation of ERK and subsequent neuronal- and endocrine-specific cellular outcomes, such as induction of neuroendocrine-specific genes and extension of neuritic processes (neuritogenesis). | SIGNOR-276609 |
P52630 | P29597 | 0 | phosphorylation | up-regulates activity | 0.789 | JAK1 and TYK2 will phosphorylate and activate STAT1 and STAT2 respectively, leading to the formation of the ternary interferon-stimulated gene factor 3 (ISGF3) complex, composed of STAT1, STAT2 and interferon regulatory factor 9 (IRF9). | SIGNOR-279133 |
P21333 | Q13153 | 0 | phosphorylation | up-regulates | 0.789 | In flna, the pak1-binding site involves tandem repeat 23 in the carboxyl terminus and phosphorylation takes place on serine 2152. | SIGNOR-92065 |
O15169 | Q5JTC6 | 0 | relocalization | up-regulates activity | 0.789 | Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. | SIGNOR-171886 |
Q9BXW4 | O95352 | 0 | binding | up-regulates activity | 0.789 | Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe | SIGNOR-191540 |
P38398 | Q92878 | 0 | binding | up-regulates | 0.789 | Brca1 interacts in vitro and in vivo with hrad50. Brca1 is important for the cellular responses to dna damage that are mediated by the hrad50-hmre11-p95 complex. | SIGNOR-69701 |
P00451 | P04275 | 0 | binding | up-regulates activity | 0.789 | Binding of FVIII to VWF is needed to maintain appropriate plasma levels, as FVIII plasma levels and half-life are remarkably reduced in the absence of VWF | SIGNOR-251967 |
P13639 | O00418 | 0 | phosphorylation | down-regulates | 0.788 | Ef-2 kinase phosphorylates ef-2 at 3 threonine residues: thr-53, thr-56, thr-58. Phosphorylation of thr56 and thr58 was found to be an ordered process, modification of thr56 preceding, and apparently being required for, phosphorylation of thr58. | SIGNOR-38556 |
P35568 | P23443 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.788 | In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities.Elimination of phosphorylation at S307/S312/S527/S636/S639 renders V5-IRS-1 partially resistant to degradation by Fbw8 | SIGNOR-236599 |
Q9UPX8 | O95886 | 0 | relocalization | up-regulates activity | 0.788 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK proteins then bind to the actin cytoskeleton and to Homer protein, which in turn interacts with mGluRs. Through these extended links, PSD95, SAPAP, SHANK and Homer proteins form a quaternary complex that brings together mGluR and NMDAR complexes in the PSD (FIG. 3). | SIGNOR-264593 |
O75197 | P04628 | 0 | binding | up-regulates activity | 0.788 | Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling. | SIGNOR-169645 |
P48740 | Q15485 | 0 | binding | up-regulates activity | 0.788 | H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway|Proteolytic activation of complement components by H-ficolin-MASP. | SIGNOR-263411 |
Q05193 | Q9Y5X1 | 0 | binding | up-regulates | 0.788 | Snx9 binds directly to bothdynamin-1 anddynamin-2. Moreover by stimulatingdynaminassembly, snx9 stimulatesdynamin's basal gtpase activity and potentiates assembly-stimulated gtpase activity on liposomes. | SIGNOR-133892 |
Q15303 | O14511 | 0 | binding | up-regulates | 0.788 | The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4. | SIGNOR-26211 |
P11142 | O95817 | 0 | binding | up-regulates activity | 0.788 | Heat shock cognate protein 70 (Hsc70) regulates protein homeostasis through its reversible interactions with client proteins. Hsc70 has two major domains: a nucleotide-binding domain (NBD), that hydrolyzes ATP, and a substrate-binding domain (SBD), where clients are bound. Members of the BAG family of co-chaperones, including Bag1 and Bag3, are known to accelerate release of both ADP and client from Hsc70. | SIGNOR-254116 |
Q13705 | P08476 | 0 | binding | up-regulates activity | 0.787 | Activin binds directly to ActR-IIB, and this complex associates with ActR-IB, which does not bind ligand on its own. In the resulting complex, ActR-IB becomes hyperphosphorylated, and this requires the kinase activity of ActR-IIB. | SIGNOR-235142 |
P46094 | P47992 | 0 | binding | up-regulates | 0.787 | Scm-1 showed a high-affinity binding to xcr1 with a kd of 10 nm and induced vigorous chemotaxis and calcium mobilization in xcr1-transfected murine l1.2 cells. | SIGNOR-71164 |
O43353 | Q13489 | 0 | polyubiquitination | up-regulates activity | 0.787 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. | SIGNOR-272715 |
Q96PU5 | O00141 | 0 | phosphorylation | down-regulates activity | 0.787 | Site‐directed mutagenesis of the SGK1 phosphorylation sites in the Nedd4‐2 protein (S382A,S468ANedd4‐2) and in the EAAT1 protein (T482AEAAT1, T482DEAAT1) significantly blunts the effect of S422DSGK1. Introduction of a negative charge at the SGK phosphorylation site in the EAAT1 protein leads to a strong stimulation of the carrier, whereas replacement with alanine markedly decreases the EAAT1‐mediated current. These observations suggest that SGK1 exerts its effect not only by phosphorylation of Nedd4‐2 but also by phosphorylation of EAAT1. | SIGNOR-263076 |
P15924 | Q99959 | 0 | binding | up-regulates quantity by stabilization | 0.787 | In contrast to the proper membrane localization of PKP2 and DSP after cotransfection of both WT proteins, mutant PKP2 C796R protein was not able to interact with FLAG-DSP to enable assembly at the junctional plaque, indicating the requirement of functional PKP2 for DSP integration into the desmosome. | SIGNOR-261254 |
O75787 | P00797 | 0 | binding | up-regulates | 0.787 | We report the expression cloning of the human renin receptor complementary dna encoding a 350-amino acid protein with a single transmembrane domain and no homology with any known membrane protein. Transfected cells stably expressing the receptor showed renin- and prorenin-specific binding. The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin i and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of map kinases erk1 and erk2 | SIGNOR-88416 |
Q16665 | P27540 | 0 | binding | up-regulates activity | 0.787 | The functional transcription factor exists as a heterodimeric complex consisting of HIF-1alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT). Association of HIF-1 with ARNT is required for its activity; however, no other role has been ascribed to this interaction. | SIGNOR-253720 |
P49682 | P02778 | 0 | binding | up-regulates activity | 0.787 | The chemokines CXCL9, 10, and 11 exert their action via CXC chemokine receptor-3 (CXCR3), a receptor highly expressed on activated T cells. | SIGNOR-260969 |
P38398 | O96017 | 0 | phosphorylation | up-regulates | 0.787 | In this study, we tested the hypothesis that the brca1-mediated regulation of recombination requires the chk2- and atm-dependent phosphorylation sites. | SIGNOR-120575 |
Q92859 | Q96B86 | 0 | binding | down-regulates activity | 0.787 | Netrin-1-neogenin interactions mediate chemoattractive axon guidance, while RGMa-neogenin interactions repel axons. | SIGNOR-268388 |
Q99835 | Q13635 | 0 | binding | down-regulates activity | 0.786 | We show that free Ptc (unbound by Hh) acts sub-stoichiometrically to suppress Smo activity and thus is critical in specifying the level of pathway activity. | SIGNOR-91709 |
P15692 | P40763 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.786 | Stat3 directly regulated the promoter of the VEGF gene. Blockade of activated Stat3 by ectopic expression of dominant-negative Stat3 significantly inhibited VEGF expression, and the growth and metastasis of human pancreatic cancer cells. | SIGNOR-259456 |
P23528 | Q8WYL5 | 0 | dephosphorylation | up-regulates activity | 0.786 | Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.|Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 by LIM-kinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). | SIGNOR-248762 |
Q14457 | Q9C0C7 | 0 | binding | up-regulates activity | 0.786 | we show that the BECLIN 1-VPS34 complex is tethered to the cytoskeleton through an interaction between the BECLIN 1-interacting protein AMBRA1 and dynein light chains 1/2. | SIGNOR-168252 |
P32238 | P06307 | 0 | binding | up-regulates | 0.786 | Cck8 interacts with nanomolar affinities with two different receptors designated cck-a and cck-b | SIGNOR-68474 |
P41597 | P13500 | 0 | binding | up-regulates activity | 0.786 | The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. | SIGNOR-255113 |
P32248 | O00585 | 0 | binding | up-regulates | 0.786 | The regulated expression of the chemokine secondary lymphoid tissue chemokine (slc/ccl21) and its corresponding receptor, ccr7. | SIGNOR-117566 |
Q96RJ3 | Q9Y275 | 0 | binding | up-regulates activity | 0.785 | Baff specifically binds baff receptor | SIGNOR-135713 |
O14974 | O75116 | 0 | phosphorylation | down-regulates activity | 0.785 | Rho kinase is known to control smooth muscle contractility by phosphorylating the 110 kDa myosin-targetting subunit (MYPT1) of the myosin-associated form of protein phosphatase 1 (PP1M). Phosphorylation of MYPT1 at Thr695 has previously been reported to inhibit the catalytic activity of PP1. Here, we show that the phosphorylation of Thr850 by Rho kinase dissociates PP1M from myosin, providing a second mechanism by which myosin phosphatase activity is inhibited. | SIGNOR-249164 |
O60610 | P61586 | 0 | null | up-regulates activity | 0.785 | We find that the small GTPase Rho regulates R-cadherin adherens junction formation via Dia1 (also known as p140mDia) and profilin-1-mediated signaling pathway. The role played by Rho in regulating R-cadherin is underscored by the fact that constitutively active RhoA(Q63L) induces R-cadherin junction formation in MDA-MB-231 cells.|Data presented thus far demonstrated that Rho, Dia1, and profilin-1 were required for R-cadherin junction formation in N480 cells. | SIGNOR-253108 |
P30305 | O14757 | 0 | phosphorylation | down-regulates activity | 0.785 | Here, we show that cdc25b is phosphorylated by chk1 in vitro on multiple residues, including s230 and s563.We show that the s230-phosphorylated form of cdc25b is located at the centrosome from early s phase until mitosis. Furthermore, mutation of s230 to alanine increases the mitotic-inducing activity of cdc25b | SIGNOR-149898 |
O60934 | Q13535 | 0 | phosphorylation | up-regulates | 0.785 | We demonstrate that mrn and atr/atr-interacting protein (trip) interact with each other, and the forkhead-associated/breast cancer c-terminal domains (fha/brct) of nbs1 play a significant role in mediating this interaction. Mutations in the fha/brct domains do not prevent atr activation but specifically impair atr-mediated nbs1 phosphorylation at ser-343, which results in a defect in the s-phase checkpoint. | SIGNOR-155214 |
O15169 | P48729 | 0 | phosphorylation | up-regulates activity | 0.785 | Four sites, S80, S82, S222, and S473, were identified to be PP1 regulated (Supplementary Figure 3). Three of them (S80, S82, and S473) were also phosphorylated in vitro by CKI and are conserved between axin1 and axin2/conductin.|This suggests that cumulative phosphorylation of axin is required for it to fully downregulate Wnt/beta_catenin signaling. | SIGNOR-249191 |
P49238 | P78423 | 0 | binding | up-regulates | 0.785 | Fractalkine/cx3cl1 is a membrane-tethered chemokine that functions as a chemoattractant and adhesion protein by interacting with the receptor cx3cr1. | SIGNOR-109135 |
P62136 | P41236 | 0 | binding | down-regulates | 0.785 | Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1. | SIGNOR-160651 |
P24928 | Q9NYV4 | 0 | phosphorylation | up-regulates activity | 0.784 | Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna | SIGNOR-176805 |
P04628 | Q8N474 | 0 | binding | down-regulates | 0.784 | Frp inhibits wnt signaling through interactions with wnt and/or formation of nonfunctional complexes with the frizzled receptor. here we demonstrate that frza, a sfrp that is highly expressed in vascular endothelium and a variety of epithelium, specifically binds to wnt-1 protein, but not wnt-5a protein, and modulates wnt-1 signaling. | SIGNOR-71423 |
P32248 | Q99731 | 0 | binding | up-regulates activity | 0.784 | CCL19 and CCL21 are endogenous agonists for the seven-trans membrane receptor CCR7. | SIGNOR-278123 |
P34925 | P41221 | 0 | binding | up-regulates | 0.784 | Purified human RYK binds to mouse Wnt1, 3a and 5a expressed in HEK293 cells. Separate experiments show that human RYK also immunopreciptitates human VANGL2 when the proteins are co-expressed in HEK293 cells. | SIGNOR-258970 |
P30550 | P07492 | 0 | binding | up-regulates | 0.784 | Indeed, many potent mitogens such as thrombin, lysophosphatidic acid (lpa), gastrin-releasing peptide (grp), endothelin and prostaglandins stimulate cell proliferation by acting on their cognate gpcrs in various cell types. | SIGNOR-152676 |
P24385 | P49841 | 0 | phosphorylation | down-regulates | 0.783 | Phosphorylation of cyclin d1 on a single threonine residue near the carboxyl terminus (thr-286) positively regulates proteasomal degradation of d1. Now, we demonstrate that glycogen synthase kinase-3beta (gsk-3beta) phosphorylates cyclin d1 specifically on thr-286, thereby triggering rapid cyclin d1 turnover now, we demonstrate that glycogen synthase kinase-3beta (gsk-3beta) phosphorylates cyclin d1 specifically on thr-286, thereby triggering rapid cyclin d1 turnover. | SIGNOR-144818 |
Q9UKT4 | P53350 | 0 | phosphorylation | down-regulates | 0.783 | We propose that the balance of evi5 and polo-like kinase activities determines the timely accumulation of emi1 and cyclin, ensuring mitotic fidelity. | SIGNOR-142949 |
P32239 | P01350 | 0 | binding | up-regulates | 0.783 | A segment of five amino acids in the second extracellular loop of the cck-b receptor was shown to be essential for the high affinity of the natural peptide agonits, gastrin, | SIGNOR-66987 |
Q8WUP2 | Q96AC1 | 0 | binding | up-regulates activity | 0.783 | Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we demonstrate that Kindlin-2-Y193 phosphorylation regulates Kindlin-2-mediated cell spreading and migration. | SIGNOR-266108 |
P15391 | P20023 | 0 | binding | up-regulates activity | 0.783 | Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, designated C3d, it coassociates with CD19 on B cells to amplify BCR signaling. | SIGNOR-266642 |
P12694 | Q8N3J5 | 0 | dephosphorylation | up-regulates activity | 0.783 | BCKD is inhibited by phosphorylation of its E1alpha subunit at Ser293, which is catalyzed by BCKD kinase. During BCAA excess, phosphorylated Ser293 (pSer293) becomes dephosphorylated through the concerted inhibition of BCKD kinase and the activity of an unknown intramitochondrial phosphatase. Using unbiased, proteomic approaches, we have found that a mitochondrial-targeted phosphatase, PP2Cm, specifically binds the BCKD complex and induces dephosphorylation of Ser293 in the presence of BCKD substrates | SIGNOR-248758 |
Q92843 | O43521 | 0 | binding | down-regulates | 0.783 | Bim binds prosurvival proteins comparably. The members that promote cell survival, including mammalian bcl-2, bcl-xl,bcl-w, mcl-1, and a1. | SIGNOR-133832 |
Q01718 | P01189 | 0 | binding | up-regulates activity | 0.783 | Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP). | SIGNOR-268615 |
Q14203 | P30622 | 0 | binding | up-regulates activity | 0.782 | MT-unbound CLIP-170 can adopt a folded conformation through an intramolecular interaction of its terminal domains. Binding to MTs correlates with the unfolding of CLIP-170, which allows the interaction of the COOH-terminal domain with its binding partners, such as dynactin, resulting in their recruitment to the MT tip. The NH2 terminus of p150Glued binds directly to the COOH terminus of CLIP-170 through its second metal-binding motif. | SIGNOR-252164 |
P43694 | Q8WW38 | 0 | binding | down-regulates activity | 0.782 | FOG-2 associates physically with the N-terminal zinc finger of GATA-4 both in vitro and in vivo. This interaction appears to modulate specifically the transcriptional activity of GATA-4 because overexpression of FOG-2 in both NIH 3T3 cells and primary rat cardiomyocytes represses GATA-4-dependent transcription from multiple cardiac-restricted promoters. | SIGNOR-236959 |
Q96B36 | P31749 | 0 | phosphorylation | down-regulates activity | 0.782 | Treatment of these cells with 4-hydroxytamoxifen stimulated the phosphorylation of wt PRAS40 but not the mutant PRAS40 in which Thr-246 was mutated. These results demonstrate that activation of Akt alone is sufficient to induce phosphorylation of PRAS40 | SIGNOR-252544 |
P46531 | O14672 | 0 | cleavage | up-regulates activity | 0.782 | ADAM10-mediated Notch1 cleavage is the rate limiting-step for release of the NICD and subsequent activation of Notch1 signaling. In T cells ADAM10-mediated Notch1 shedding controls T cell development | SIGNOR-259838 |
P01019 | P12821 | 0 | cleavage | up-regulates activity | 0.782 | Angiotensin I-converting enzyme is a zinc metallopeptidase that plays an important role in blood pressure regulation by cleaving the inactive decapeptide angiotensin I to angiotensin II, a potent vasopressor octapeptide. | SIGNOR-253326 |
P78552 | P05112 | 0 | binding | up-regulates | 0.782 | It is now known that this alternate receptor is a heterodimer, the type ii il-4 receptor or the il-13 receptor, which is comprised of IL-4R And IL-13R1. | SIGNOR-100759 |
P43220 | P01275-PRO_0000011258 | 0 | binding | up-regulates activity | 0.782 | GLP-1 and GIP exert their physiological actions via stimulation of the two G protein-coupled receptors (GPCRs): the GLP-1 receptor (GLP-1R) and the GIP receptor (GIPR), respectively. | SIGNOR-278133 |
P49682 | Q07325 | 0 | binding | up-regulates activity | 0.782 | The chemokines CXCL9, 10, and 11 exert their action via CXC chemokine receptor-3 (CXCR3), a receptor highly expressed on activated T cells. | SIGNOR-260970 |
P56945 | Q14289 | 0 | phosphorylation | up-regulates activity | 0.782 | Pyk2 knockdown also decreased p130Cas.|p130Cas and paxillin can be phosphorylated by Fak or Pyk2, and bind directly to these kinases. | SIGNOR-280100 |
P43220 | P01275 | 0 | binding | up-regulates | 0.782 | In the present study we stably expressed the rat b-cell glp-i receptor in cho cells and studied binding characteristics and receptor activation utilizing the naturally occurring receptor agonist glp-i(7-36)-amide (glp-i), the proglucagon-derived glp-i-related peptide oxyntomodulin, the glp-i receptor agonist exendin-4, and the specific antagonist exendin | SIGNOR-34855 |
P04180 | P02647 | 0 | binding | up-regulates activity | 0.782 | Activation of LCAT by apolipoprotein (apo) A-I on nascent (discoidal) high density lipoproteins (HDL) is essential for formation of mature (spheroidal) HDL during the antiatherogenic process of reverse cholesterol transport. After attachment of LCAT to discoidal HDL, the helix 5/5 domains in apoA-I form amphipathic presentation tunnels for migration of hydrophobic acyl chains and amphipathic UC from the bilayer to the phospholipase A2-like and esterification active sites of LCAT, respectively. | SIGNOR-252103 |
Q9NT62 | Q9BXW4 | 0 | binding | up-regulates activity | 0.782 | Lc3-i is activated by the same atg7 involved in atg12 conjugation, transferred to atg3, a second e2-like enzyme, and finally conjugated to pe | SIGNOR-191552 |
P46531 | Q86Y01 | 0 | ubiquitination | up-regulates activity | 0.781 | The human Deltex (DTX1) gene encodes a cytoplasmic protein that functions as a positive regulator of the Notch signaling pathway. | SIGNOR-85942 |
P05412 | P27361 | 0 | phosphorylation | up-regulates | 0.781 | Up-regulation of c-jun mrna in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-jun n-terminal kinases are required for efficient up-regulation of c-jun protein. | SIGNOR-91379 |
P40238 | P40225 | 0 | binding | up-regulates | 0.781 | Thrombopoietin(tpo) controls the formation of megakaryocytes and platelets from hematopoietic stem cells via activation of the c-mplreceptorand multiple downstream signal transduction pathways. | SIGNOR-113955 |
P28482 | Q16690 | 0 | dephosphorylation | down-regulates | 0.781 | Here we demonstrate that dusp5, an inducible nuclear phosphatase, interacts specifically with erk2 via a kinase interaction motif (kim) within its amino-terminal noncatalytic domain. This binding determines the substrate specificity of dusp5 in vivo, as it inactivates erk2 but not jun n-terminal protein kinase or p38 map kinase. | SIGNOR-134049 |
P54132 | O14757 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.781 | We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence which is conserved in all primates.Phosphorylation on BLM Thr171 and Ser175 depends on prior phosphorylation at Thr182 by Chk1/Chk2. Thr182 phosphorylation not only controls BLM ubiquitylation and degradation during mitosis but is also a determinant for its localization on the ultrafine bridges. | SIGNOR-276909 |
P12931 | P18031 | 0 | dephosphorylation | up-regulates activity | 0.781 | Incubation of the inactivated c-Src with PTP1B results in a dose-dependent reactivation of c-Src tyrosine kinase activity. Incubation of c-Src with 2 or 10 g of PTP1B results in partial or full restoration of c-Src kinase activity, respectively. The activation is accompanied by dephosphorylation of c-Src, both of Tyr-419 and of Tyr-530 | SIGNOR-245299 |
Q13158 | Q15628 | 0 | binding | up-regulates activity | 0.781 | Tradd recruits fadd | SIGNOR-177958 |
Q15796 | Q96PU5 | 0 | ubiquitination | down-regulates activity | 0.781 | Through its ww domain, nedd4l specifically recognizes a tgf-beta-induced phosphothr-protyr motif in the linker region, resulting in smad2/3 polyubiquitination and degradation | SIGNOR-217622 |
O14836 | Q9Y275 | 0 | binding | up-regulates | 0.781 | Tumor necrosis factor (tnf) receptor superfamily member taci is a high affinity receptor for tnf family members april and blys. | SIGNOR-81360 |
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