IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P31431 | P02751 | 0 | binding | up-regulates activity | 0.711 | Sdc4 is a high affinity receptor for fibronectin (FN) […] Therefore, we conclude that Sdc4 binds FN on activated satellite cells. | SIGNOR-255846 |
P45985 | O43318 | 0 | phosphorylation | up-regulates activity | 0.711 | Mitogen-activated protein kinase kinase 4 (mkk4)/stress-activated protein kinase/extracellular signal-regulated kinase (sek1), a dual-specificity kinase that phosphorylates and activates jnk, synergized with tak1 in activating jnk.Taken together, these results identify TAK1 as a regulator in the HPK1 --> TAK1 --> MKK4/SEK1 --> JNK kinase cascade and indicate the involvement of JNK in the TGF-beta signaling pathway. | SIGNOR-50618 |
Q6UWB1 | Q8NEV9 | 0 | binding | up-regulates | 0.711 | Wsx-1 and glycoprotein 130 constitute a signal-transducing receptor for il-27. | SIGNOR-121799 |
P29353 | P35968 | 0 | relocalization | up-regulates activity | 0.711 | In a similar fashion, KDR associates with Grb2 and Nck in a ligand-dependent fashion, suggesting Shc, Grb2, and Nck as potential candidates involved in the regulation of endothelial function. | SIGNOR-261949 |
P61586 | Q9UKW4 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.711 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). | SIGNOR-260584 |
Q8TEW0 | Q05513 | 0 | phosphorylation | up-regulates | 0.711 | These results imply that serine 827 in the apkc binding site of par-3 is a target of apkc and that the regulated interaction between a protein kinase, apkc, and its substrate, par-3, plays an essential role in the establishment of cell polarity | SIGNOR-94523 |
Q01105 | P12544 | 0 | cleavage | down-regulates | 0.711 | Gzma cleaved the nucleosome assembly protein set after lys176 and disrupted its nucleosome assembly activity. | SIGNOR-110462 |
Q9H461 | P34925 | 0 | binding | up-regulates | 0.711 | Interaction between ryk and fz has been reported, suggesting that the two proteins may form a multi-receptor complex signalling through the canonical pathway | SIGNOR-150010 |
Q8IU57 | Q8IZJ0 | 0 | binding | up-regulates | 0.71 | Il-28 and il-29 interacted with a heterodimeric class ii cytokine receptor that consisted of il-10 receptor beta (il-10rbeta) and an orphan class ii receptor chain, designated il-28ralpha. | SIGNOR-96206 |
P32246 | P10147 | 0 | binding | up-regulates activity | 0.71 | The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. | SIGNOR-255114 |
P62834 | O95398 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.71 | Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. | SIGNOR-263956 |
Q13627 | P61962 | 0 | binding | up-regulates activity | 0.71 | Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. HAN11 might target DYRKs to cytosolic locations for regulation of specific cellular functions. | SIGNOR-260630 |
Q96GD4 | Q9P2J3 | 0 | binding | up-regulates activity | 0.71 | Aurora B Interacts with the Cul3 Complex during Mitosis and Is Ubiquitylated in a Cul3-Dependent Manner In Vivo and In Vitro. our results suggest that Cul3/KLHL9/KLHL13 activity is required to remove the chromosomal passenger protein Aurora B from mitotic chromosomes, and that Aurora B is ubiquitylated in vivo and in vitro in a KLHL9/13-dependent manner. We conclude that the Cul3/KLHL9/KLHL13 E3 ligase is an important cell-cycle regulator which, in addition to the anaphase-promoting complex (APC), coordinates mitotic progression and completion of cytokinesis. | SIGNOR-271658 |
P29353 | P06213 | 0 | binding | up-regulates | 0.71 | The npxy motif around 960-tyr residue of the insulin receptor binds to the n-terminal ptb domain of shc. | SIGNOR-84251 |
P31785 | P13232 | 0 | binding | up-regulates | 0.71 | The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, il-15, il-2, il21 | SIGNOR-108864 |
P62330 | Q9NRD0 | 0 | binding | down-regulates quantity by destabilization | 0.71 | Fbx8 Is a Component of the SCF Complex and Mediates Ubiquitination of Arf6. We first examined whether Fbx8 makes a complex with Cul1, through its binding to Skp1. We expressed GST-tagged Fbx8 together with FLAG-tagged Skp1 and Myc-tagged Cul1 in Cos-7 cells and found that Myc-Cul1 is coprecipitated with GST-Fbx8 in the presence of FLAG-Skp1 (Figure 1A). | SIGNOR-271764 |
Q99466 | Q92585 | 0 | binding | up-regulates | 0.71 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes4 | SIGNOR-84916 |
P10070 | O43791 | 0 | ubiquitination | down-regulates quantity | 0.71 | RNAi knockdown of Spop (a substrate-binding adaptor for the cullin3-based ubiquitin E3 ligase) in Sufu mutant mouse embryonic fibroblasts (MEFs) can restore the levels of Gli2 and Gli3 full-length proteins | SIGNOR-268860 |
O14836 | O75888 | 0 | binding | up-regulates | 0.71 | Tumor necrosis factor (tnf) receptor superfamily member taci is a high affinity receptor for tnf family members april and blys. | SIGNOR-81308 |
P06493 | P24522 | 0 | binding | down-regulates | 0.71 | Gadd45 has now been found to directly inhibit the activity of cdc2/cyclin b1 complex | SIGNOR-68221 |
Q14814 | Q9UQL6 | 0 | binding | down-regulates | 0.71 | The histone deacetylase hdac-5, upon dephosphorylation and translocation to the nucleus, directly inactivates mef2, preventing myogenesis. | SIGNOR-84029 |
P04049 | Q969H4 | 0 | binding | up-regulates | 0.71 | Here we demonstrate that the connector enhancer of ksr1, cnk1, mediates src-dependent tyrosine phosphorylation and activation of raf-1. Cnk1 binds preactivated raf-1 and activated src and forms a trimeric complex. | SIGNOR-135674 |
P05067 | P45983 | 0 | phosphorylation | up-regulates | 0.71 | Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in sh-sy5y neuroblastoma cells. We found that the threonine 668 within the abetapp intracellular domain (aid or elsewhere aicd) is indeed phosphorylated by jnk1 | SIGNOR-117852 |
P36897 | Q9HAU4 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.71 | Smad7 Recruits Smurf2 to the TGFβ Receptor Complex. Here, we identify Smurf2, a C2-WW-HECT domain ubiquitin ligase and show that Smurf2 associates constitutively with Smad7. Smurf2 is nuclear, but binding to Smad7 induces export and recruitment to the activated TGF beta receptor, where it causes degradation of receptors and Smad7 via proteasomal and lysosomal pathways. | SIGNOR-272938 |
Q15796 | P27037 | 0 | phosphorylation | up-regulates activity | 0.71 | In ACVR2A/B dKO parental cells, only ACVR2A , but not ACVR2A , could rescue both pSMAD2 and pSMAD1/5 (Fig\u00a04B).|In marked contrast, in ACVR2A/B dKO HOM1 cells, ACVR2A restored SMAD1/5 phosphorylation, but not SMAD2 phosphorylation (Fig\u00a04C). | SIGNOR-279786 |
O43294 | Q14289 | 0 | phosphorylation | up-regulates activity | 0.71 | Hic-5 is a CAKbeta-binding protein localized at focal adhesions. Here we show that overexpression of CAKbeta or Fyn, but not FAK, enhanced the tyrosine phosphorylation of coexpressed Hic-5 in COS-7 cells. The Y60F mutant of Hic-5 was not phosphorylated, and Hic-5 phosphorylated on tyrosine 60 was bound specifically to the SH2 domain of Csk. Specific phosphorylation of Hic-5 by CAKbeta and Fyn may activate a signaling pathway mediated by Hic-5. | SIGNOR-262876 |
Q13153 | P16333 | 0 | binding | up-regulates activity | 0.709 | Both nck and grb4 proteins could associate with receptor tyrosine kinases and the sh3-binding proteins pak, sos1, and prk2, and they synergized with v-abl and sos to induce gene expression via the transcription factor elk-1. Association of nck with pak1 may serve to link this important regulatory kinase to cell activation by growth factor receptors. | SIGNOR-236512 |
P10275 | Q9ULJ6 | 0 | binding | up-regulates activity | 0.709 | Our results demonstrate that hZimp10 is a novel AR interacting protein that augments AR-mediated transcription. Moreover, hZimp10 co-localized with AR and SUMO-1 at replication foci throughout S phase, and it was capable of enhancing sumoylation of AR in vivo. | SIGNOR-263935 |
Q13501 | Q9UHD2 | 0 | phosphorylation | up-regulates | 0.709 | Tbk-1 coordinated assembly and function of the autophagic machinery and phosphorylated the autophagic adaptor p62 (sequestosome 1) on ser-403, a residue essential for its role in autophagic clearance. | SIGNOR-191944 |
P53992 | Q9NR31 | 0 | binding | up-regulates quantity | 0.709 | Biogenesis of COPII vesicles is initiated by the activation of the small guanosine triphosphate (GTP)-binding protein secretion-associated Ras-related protein 1 (Sar1) at specialized subdomains of the ER, called ER exit sites (ERES) or transitional ER (tER). Membrane-bound Sar1 then recruits the inner COPII coat subcomplex, the Sec23/24 heterodimer. | SIGNOR-265302 |
P48431 | P35222 | 0 | binding | up-regulates activity | 0.709 | The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. | SIGNOR-242087 |
P27361 | Q13115 | 0 | dephosphorylation | down-regulates activity | 0.709 | Dephosphorylation and Inactivation of ERKs|ERK1 phosphorylated on either threonine (ERK1*Y204F) or tyrosine alone (ERK1*T202A) was utilized as a substrate for HVH2. Threonine 202 and tyrosine 204 in ERK1 (53) correspond to threonine 183 and tyrosine 185 in ERK2 which are the activation-phosphorylation sites by MEK(14, 15, 16). ERK1*, a kinase-deficient mutant, was phosphorylated on both threonine and tyrosine by MEK2 (Fig. 3B). ERK1*T202A, having threonine 202 substituted by an alanine, was phosphorylated only on tyrosine while ERK1*Y204F, having tyrosine 204 substituted by a phenylalanine, was phosphorylated only on threonine (Fig. 3B). GST-HVH2 dephosphorylated all three ERK1* mutants (Fig. 3A), suggesting that double phosphorylations of adjacent threonine and tyrosine were not a prerequisite for HVH2 recognition. However, HVH2 dephosphorylated ERK1* and ERK1*T202A more efficiently than ERK1*Y204F (Fig. 3A), indicating that HVH2 preferred phosphotyrosine over phosphothreonine. Interestingly, MEK also phosphorylated tyrosine residues more efficiently than threonine residues of ERK | SIGNOR-248716 |
P61586 | Q9P2F6 | 0 | gtpase-activating protein | down-regulates activity | 0.709 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). | SIGNOR-260472 |
P98170 | O43464 | 0 | binding | down-regulates | 0.709 | Here we report that a serine protease called htra2/omi is released from mitochondria and inhibits the function of xiap by direct binding in a similar way to diablo. | SIGNOR-110834 |
P60953 | Q12982 | 0 | binding | up-regulates activity | 0.709 | Cdo-bnip-2-cdc42 complex stimulates cdc42 activation which in turn promotes p38 alpha/beta activity and cell differentiation. | SIGNOR-179861 |
O14543 | P40763 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.709 | We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells | SIGNOR-253583 |
P34925 | P04628 | 0 | binding | up-regulates | 0.709 | Mammalian ryk is a wnt coreceptor required for stimulation of neurite outgrowth | SIGNOR-129577 |
O95150 | O95407 | 0 | binding | down-regulates | 0.709 | Tl1a, is a ligand for dr3 and decoy receptor tr6/dcr3. Tr6-fc protein antagonizes nf-kappab activation and apoptosis induced by tl1a | SIGNOR-116256 |
Q13635 | P10071 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.709 | GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin | SIGNOR-188884 |
P37023 | O95393 | 0 | binding | up-regulates | 0.709 | Taken together, our results sug- gest that bmp9 and bmp10 are two spe- cific alk1 ligands that may physiologi- cally trigger the effects of alk1 on angiogenesis | SIGNOR-150201 |
P16220 | Q16566 | 0 | phosphorylation | up-regulates activity | 0.708 | Pka, ca2+-calmodulin-dependent kinase iv (camkiv), msk, p70s6k and rsk phosphorylate creb. All these kinases target CREB on S133 to activate CREB. | SIGNOR-102722 |
Q15797 | Q9HCE7 | 0 | ubiquitination | down-regulates | 0.708 | Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps | SIGNOR-195660 |
O15198 | O00238 | 0 | phosphorylation | up-regulates activity | 0.708 | Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. | SIGNOR-255264 |
P42336 | P21860 | 0 | binding | up-regulates | 0.708 | Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. | SIGNOR-146861 |
O43524 | Q9Y243 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.708 | AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. | SIGNOR-249644 |
Q8WXD0 | P04090 | 0 | binding | up-regulates | 0.708 | Lgr7 and lgr8, are capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (camp)-dependent pathway. | SIGNOR-114585 |
P37231 | O75376 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.708 | In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcription. | SIGNOR-253507 |
Q12933 | P20333 | 0 | binding | up-regulates activity | 0.708 | Our analysis indicates that traf1 and traf2 are associated with the cytoplasmic domain of tnf-r2 in a heterodimeric complex in which traf2 contacts the receptor directly. | SIGNOR-34645 |
P98172 | Q12923 | 0 | dephosphorylation | up-regulates activity | 0.708 | Loss of PTPN13 function increases EFNB1 phosphorylation, enhances EFNB1 's interaction with ERBB1 and correlates with potentiated ERK1/2 activation.|Moreover, acquisition of PTPN13 loss-of-function mutations or its decreased expression (due to HPV infection or epigenetic silencing) may further enhance ERBB1 and EFNB1 mediated signals. | SIGNOR-277002 |
P35568 | P23458 | 0 | phosphorylation | up-regulates activity | 0.708 | Janus kinase-dependent activation of insulin receptor substrate 1 | SIGNOR-251343 |
P52333 | O15524 | 0 | binding | down-regulates activity | 0.708 | SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity.Both SOCS1 and SOCS3 can inhibit JAK tyrosine kinase activity directly through their kinase inhibitory regions (KIR). | SIGNOR-238642 |
Q14247 | Q13153 | 0 | phosphorylation | up-regulates | 0.707 | Strikingly, we find that pak1 phosphorylation of cortactin on serine residues 405 and 418 increases its association with n-wasp. Thus, pak1, by controlling the interaction between cortactin and n-wasp, could regulate the polymerization of actin during clathrin-independent endocytosis. | SIGNOR-169690 |
P61587 | Q13464 | 0 | phosphorylation | up-regulates | 0.707 | We show that rock phosphorylates endogenous rhoe at serine 11 upon cell stimulation with platelet-derived growth factor. Phosphorylation has no effect on rhoe binding to rock i, but instead increases rhoe protein stability. | SIGNOR-134703 |
Q9NPG1 | P41221 | 0 | binding | up-regulates activity | 0.707 | Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. | SIGNOR-141434 |
P04626 | Q9UJM3 | 0 | binding | down-regulates activity | 0.707 | The cytoplasmic protein MIG6 (mitogen-induced gene 6; also known as ERRFI1) interacts with and inhibits the kinase domains of EGFR and ERBB2 | SIGNOR-252077 |
P10636-2 | Q7KZI7 | 0 | phosphorylation | down-regulates activity | 0.707 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates somesites in the flanking domains, notably Ser214. This type of phosphorylation strongly reduces tau’s affinityfor microtubules, and at the same time inhibits tau’s assembly into PHFs. | SIGNOR-275437 |
P01106 | P27361 | 0 | phosphorylation | up-regulates activity | 0.707 | ERK1 phosphorylates MYC Ser62 resulting in MYC stabilization and activation | SIGNOR-236250 |
P10636 | Q7KZI7 | 0 | phosphorylation | down-regulates activity | 0.707 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates somesites in the flanking domains, notably Ser214. This type of phosphorylation strongly reduces tau’s affinityfor microtubules, and at the same time inhibits tau’s assembly into PHFs. | SIGNOR-275436 |
P78504 | O76050 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.707 | We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation.|Jagged1 is also regulated by the E3 ligase Neuralized-like1 (Neurl1), which induces the monoubiquitination of membrane tethered Jagged1 in the C-terminal region. | SIGNOR-278772 |
Q16620 | Q06124 | 0 | dephosphorylation | down-regulates activity | 0.707 | Conversely, PTPN11 knockdown lead to increased Y 515 phosphorylation of TrkB compared to the scramble control in the neuronal cells.|This study established that TrkB activation as demonstrated by receptor phosphorylation at Tyr 515 in the SH-SY5Y cells is negatively regulated by PTPN11 actions. | SIGNOR-277123 |
P24864 | Q13309 | 0 | binding | down-regulates quantity by destabilization | 0.707 | Biochemical studies showed that Skp2 interacts specifically with cyclin E and thereby promotes its ubiquitylation and degradation both in vivo and in vitro. These results suggest that specific degradation of cyclin E and p27(Kip1) is mediated by the SCF(Skp2) ubiquitin ligase complex, and that Skp2 may control chromosome replication and centrosome duplication by determining the abundance of cell cycle regulators. Skp2 was associated with Cul1, but not Cul3. | SIGNOR-272566 |
P35568 | P27361 | 0 | phosphorylation | down-regulates activity | 0.707 | Rin beta-cells exposed to high glucose exhibited increased c-jun n-terminal kinase (jnk) and erk1/2 activity, which was associated with increased irs-1 phosphorylation at serine (ser)(307) and ser(612), respectively, that inhibits coupling of irs-1 to the insulin receptor and is upstream of the inhibition of irs-1 tyrosine phosphorylation. | SIGNOR-123177 |
P20226 | O14981 | 0 | binding | up-regulates activity | 0.707 | We present evidence that the NC2alpha subunit interacts with BTAF1. Addition of NC2alpha or the NC2 complex can stimulate the ability of BTAF1 to interact with TBP. | SIGNOR-263919 |
P06213 | P01344 | 0 | binding | up-regulates | 0.707 | Therefore, these results provide genetic evidence that the growth-promoting function of igf-ii during mouse embryogenesis is mediated in part by signaling through the insulin receptor. | SIGNOR-50719 |
Q15303 | O14944 | 0 | binding | up-regulates | 0.706 | For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4. | SIGNOR-191788 |
P40763 | P08581 | 0 | phosphorylation | up-regulates activity | 0.706 | It has been reported that c-Met can activate STAT3 at the endosome and phosphorylated STAT3 induced by c-Met is colocalized with EEA1, an early endosome marker. | SIGNOR-280041 |
P10451 | P09237 | 0 | cleavage | up-regulates activity | 0.706 | In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to α9β1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA. | SIGNOR-253321 |
Q02078 | Q9UQL6 | 0 | binding | down-regulates | 0.706 | The histone deacetylase hdac-5, upon dephosphorylation and translocation to the nucleus, directly inactivates mef2, preventing myogenesis. | SIGNOR-84023 |
O15198 | P36894 | 0 | phosphorylation | up-regulates activity | 0.706 | To ascertain whether overexpression of BMPr1A can initiate adipocyte lineage commitment in the absence of its BMP ligand, constitutively active (CA)-BMPr1A and CA-BMPr1B were expressed in C3H10T1/2 stem cells using a mouse stem cell virus (MSCV) retroviral system. […]Thus, their overexpression provoked a substantial rise in the phosphorylation of Smad1/5/8 and p38 MAPK, known downstream phosphorylated intermediates in the BMP signaling pathway. | SIGNOR-255772 |
P04637 | Q9H4B4 | 0 | phosphorylation | up-regulates activity | 0.706 | Upon exposure of cells to hydrogen peroxide (h(2)o(2)) phosphorylation of p53 was rapidly induced in human fibroblast gm00637, and this phosphorylation occurred on serine 9, serine 15, serine 20, but not on serine 392. In addition, h(2)o(2)-induced phosphorylation of p53 was followed by induction of p21, suggesting functional activation of p53. Ectopic expression of a plk3 dominant negative mutant, plk3(k52r), in gm00637 cells suppressed h(2)o(2)-induced serine 20 phosphorylation. Taken together, our studies strongly suggest that the oxidative stress-induced activation of p53 is at least in part mediated by plk3. | SIGNOR-109239 |
P35568 | P45984 | 0 | phosphorylation | down-regulates | 0.706 | Map kinases and mtor mediate insulin-induced phosphorylation ofinsulinreceptor substrate-1 on serine residues 307, 612 and 632 | SIGNOR-118877 |
P62993 | Q05397 | 0 | binding | up-regulates activity | 0.706 | Src-mediated phosphorylation of FAK at Tyr925 creates an SH2 binding site for the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which leads to the activation of Ras and the extracellular signal-regulated kinase-2 (ERK2) cascade. | SIGNOR-257733 |
P43403 | Q9Y2R2 | 0 | dephosphorylation | down-regulates | 0.706 | Native ptpn22 dephosphorylated lck and zap70 at their activating tyrosine residues tyr-394 and tyr-493, respectively, but not at the regulatory tyrosines tyr-505 (lck) or tyr-319 (zap70). | SIGNOR-144345 |
P42229 | P27361 | 0 | phosphorylation | up-regulates | 0.706 | Serine 780 is the only substrate in full-length stat5a for active erk | SIGNOR-66247 |
O75030 | P28482 | 0 | phosphorylation | down-regulates | 0.705 | The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73the results suggested that s1p reduced melanin synthesis via s1p(3) receptor-mediated erk and rsk-1 activation, and subsequent mitf dual phosphorylation and degradation. | SIGNOR-75030 |
O15169 | Q9H2K2 | 0 | ADP-ribosylation | down-regulates quantity by destabilization | 0.705 | Together, these findings are consistent with the hypothesis that TNKS promotes the ubiquitination and degradation of axin, which may be mediated, at least in part, through the direct PARsylation of axin. | SIGNOR-263378 |
P78352 | Q9P1A6 | 0 | binding | up-regulates activity | 0.705 | SAPAPs are specifically expressed in neuronal cells and enriched in the PSD fraction. SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area. | SIGNOR-264210 |
P45983 | Q9Y6W6 | 0 | dephosphorylation | down-regulates | 0.705 | Mkp-5 directly dephosphorylates sapk/jnk and p38 in vitromkp-5 binds to p38 and sapk/jnk, but not to mapk/erk, and inactivates p38 and sapk/jnk | SIGNOR-68986 |
Q14683 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.705 | Atm phosphorylates Smc1 on serines 957 and 966 in vitro and in vivo, and expression of an Smc1 protein mutated at these phosphorylation sites abrogates the ionizing irradiation-induced S phase cell cycle checkpoint | SIGNOR-255589 |
P11802 | P30304 | 0 | dephosphorylation | up-regulates activity | 0.705 | Invalidation of CDK4 has no impact by itself on the cell proliferation, but invalidation of CDC25A prevents the dephosphorylation of CDK6 (Y24) and CDK4 (Y17) residues, and impedes their association with CCNDs. | SIGNOR-267568 |
Q16513 | O15530 | 0 | phosphorylation | up-regulates | 0.705 | It is shown that activation in vitro and in vivo involves the activation loop phosphorylation of prk1/2 by 3-phosphoinositide-dependent protein kinase-1 (pdk1) /pdk1 phosphorylates the prks at their conserved activation loop threonines (thr-774 and thr-816 for prk1 and prk2, respectively) | SIGNOR-76710 |
Q96FF9 | P53350 | 0 | phosphorylation | down-regulates activity | 0.705 | Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. | SIGNOR-276122 |
Q09472 | P35222 | 0 | binding | up-regulates | 0.705 | Ctnnb1 forms a ternary complex with lef1 and ep300 that is disrupted by ctnnbip1 binding | SIGNOR-76987 |
Q08050 | P53350 | 0 | phosphorylation | up-regulates | 0.705 | It has been reported that plk1 could directly phosphorylate foxm1 at ser-715 and ser-724 for full activation and proper mitotic progression | SIGNOR-187892 |
P08047 | P45983 | 0 | phosphorylation | up-regulates | 0.705 | In addition, for mutation of the jnk-1 phosphorylated residues of sp1, namely, sp1(t278/739a) and sp1(t278/739d), the effect of ga on sp1 stability was reversed. | SIGNOR-184194 |
P35222 | Q12864 | 0 | binding | up-regulates activity | 0.705 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265856 |
Q14814 | Q13164 | 0 | phosphorylation | up-regulates | 0.705 | Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b. the sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. | SIGNOR-236041 |
Q13480 | P12931 | 0 | phosphorylation | up-regulates | 0.704 | Using both mutagenesis and mass spectrometry approaches, y242, y259, y317, y373 and y627 of gab1 were identified to be phosphorylated by c-src a gab1 mutant with substitutions of the src phosphorylation sites failed to promote hgf-induced dna synthesis | SIGNOR-236314 |
P60484 | P19784 | 0 | phosphorylation | down-regulates activity | 0.704 | We used mass spectrometric methods to identify Ser(370) and Ser(385) as in vivo phosphorylation sites of PTEN. These sites also are phosphorylated by CK2 in vitro, and phosphorylation inhibits PTEN activity towards its substrate, PIP3. We also identify a novel in vivo phosphorylation site, Thr(366). | SIGNOR-251025 |
P10275 | P08238 | 0 | binding | up-regulates activity | 0.704 | The unliganded AR resides predominately in the cytoplasm as a heteromeric complex with hsp90 and other chaperone proteins. These chaperone proteins maintain AR in a form that is receptive to ligand binding. Regulation of gene expression by androgen-activated AR occurs through receptor nuclear translocation, dimerization, and binding to androgen response elements (AREs) in the DNA of target genes. | SIGNOR-251535 |
O95644 | P48454 | 0 | relocalization | up-regulates | 0.704 | The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. | SIGNOR-179796 |
P61088 | Q96FW1 | 0 | binding | down-regulates | 0.704 | The deubiquitinating enzyme otub1 suppresses rnf168 dependent ubiquitination by direct the e2 ligase ubc13 | SIGNOR-175050 |
P27361 | Q99956 | 0 | binding | down-regulates | 0.704 | Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein. | SIGNOR-176589 |
Q8N122 | O75385 | 0 | phosphorylation | down-regulates activity | 0.704 | ULK1 phosphorylates RPTOR at S792, S855, and S859.|When active, ULK1 inhibits MTOR complex 1 through phosphorylation of RPTOR, which has the effect of limiting RPTOR-mediated recruitment of MTOR substrates to MTOR complex 1 [ ]. | SIGNOR-278461 |
Q92997 | Q969G9 | 0 | binding | down-regulates | 0.704 | Naked (nkd)1 and nkd2 are mammalian homologs of drosophila naked cuticle, which negatively regulates canonical wnt signaling by binding dishevelled. various reports using cell culture assays indicate that nkd-mediated wnt antagonism involves dvl degradation | SIGNOR-167984 |
P21453 | P31749 | 0 | phosphorylation | up-regulates activity | 0.704 | Activated akt binds to edg-1 and phosphorylates the third intracellular loop at the t(236) residue. Transactivation of edg-1 by akt is not required for g(i)-dependent signaling but is indispensable for rac activation, cortical actin assembly, and chemotaxis | SIGNOR-252467 |
P30260 | P06493 | 0 | phosphorylation | up-regulates | 0.704 | Apc activation is thought to depend on apc phosphorylation and cdc20 binding. We have identified 43 phospho_sites on apc of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of apc1 and the tetratricopeptide repeat (tpr) subunits cdc27, cdc16, cdc23 and apc7. In vitro, at least 15 of the mitotic phospho_sites can be generated by cyclin_dependent kinase 1 (cdk1), and 3 by polo_like kinase 1 (plk1). Apc phosphorylation by cdk1, but not by plk1, is sufficient for increased cdc20 binding and apc activation | SIGNOR-119873 |
P03372 | P27361 | 0 | phosphorylation | up-regulates | 0.704 | In several estrogen response element-containing genes, the s118a mutation strongly reduced induction by e(2), and u0126 did not further reduce expression. Here, we show that serines 104 (s104) and 106 (s106) are also phosphorylated by mapk in vitro and upon stimulation of mapk activity in vivo.Phosphorylation at serines 104 and 106 by erk1/2 mapk is important for estrogen receptor-alpha activity | SIGNOR-156864 |
P04637 | P27361 | 0 | phosphorylation | up-regulates | 0.704 | Mutant p53 is constitutively phosphorylated at serine 15 in uv-induced mouse skin tumors: involvement of erk1/2 map kinase. | SIGNOR-100270 |
P51452 | Q8IV63 | 0 | binding | up-regulates activity | 0.704 | Vaccinia-related kinase 3 (VRK3), a member of the VRK family, is widely expressed in human tissues and increases VHR phosphatase activity through a direct binding | SIGNOR-275546 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.