IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q12879 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.525 | Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells. Moreover, we show that roscovitine, a selective Cdk5 inhibitor, blocks both long-term potentiation induction and NMDA-evoked currents in rat CA1 hippocampal neurons. Thes... | SIGNOR-250666 |
O43150 | Q14289 | 0 | phosphorylation | up-regulates activity | 0.525 | Tyrosine phosphorylation of Pap by Pyk2 or Src kinases. We have identified a new Pyk2 binding protein designated Pap. Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-... | SIGNOR-269704 |
P10636 | P53778 | 0 | phosphorylation | down-regulates activity | 0.525 | Phosphorylation of tau by SAPK3 and SAPK4 markedly reduced the ability of tau to promote microtubule assembly. SAPK3 (also called ERK6 and p38) and SAPK4 phosphorylate recombinant tau protein at multiple Ser/Thr-Pro sites that are hyperphosphorylated in PHF-tau, with SAPK4 and SAPK3 being the most effective. | SIGNOR-250087 |
P04049 | Q9BRX9 | 0 | binding | up-regulates | 0.525 | Morg1 specifically associates with several components of the erk pathway, including mp1, raf-1, mek, and erk, and stabilizes their assembly into an oligomeric complex. | SIGNOR-124476 |
Q06124 | P36888 | 0 | binding | up-regulates activity | 0.525 | Y599 was additionally found to interact with the protein tyrosine phosphatase SHP2 in a phosphorylation-dependent manner. As Y599F-Flt3-32D was unable to associate with and to phosphorylate SHP2 and since silencing of SHP2 in WT-Flt3-expressing cells mimicked the Y599F-Flt3 phenotype, we hypothesize that recruitment of... | SIGNOR-245057 |
O15503 | Q9UKV5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.525 | The ubiquitination of Insig-1 is mediated by gp78 and regulated by sterols.|gp78 mediates the degradation of Insig-1 and Insig-2. | SIGNOR-278567 |
O14727 | Q96GX9 | 0 | binding | down-regulates | 0.525 | Taken together, these results suggest that apip functions to inhibit muscle ischemic damage by binding to apaf-1 in the apaf-1/caspase-9 apoptosis pathway. | SIGNOR-126797 |
P61586 | O15013 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.525 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260535 |
P48454 | P0DP25 | 0 | binding | up-regulates | 0.525 | Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. | SIGNOR-266340 |
Q14393 | P38435 | 0 | carboxylation | up-regulates activity | 0.525 | Thus, vitamin K acts as a cofactor for GGCX via the vitamin K cycle and exerts physiological effects through its regulation of VKDPs [29]. More than 20 VKDPs have been found. Osteocalcin promotes bone formation, and blood coagulation factors II, VII, IX, and X activate blood coagulation. Matrix Gla protein suppresses c... | SIGNOR-265923 |
Q01851 | Q99578 | 0 | binding | up-regulates activity | 0.525 | we describe the evidence for a functional interaction between Brn-3a and Rin and demonstrate the role of Rin in modulating the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a. | SIGNOR-224546 |
P55011 | Q9BYP7 | 0 | phosphorylation | up-regulates activity | 0.525 | We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activ... | SIGNOR-264625 |
Q01970 | Q13237 | 0 | phosphorylation | down-regulates activity | 0.525 | PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagen... | SIGNOR-249078 |
Q92934 | P31751 | 0 | phosphorylation | down-regulates | 0.525 | Ser-136 is the major phosphoacceptor site for akt;akt can weakly phosphorilate ser-155. | SIGNOR-81114 |
Q96BI1 | Q9H6Y7 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.525 | Here, we present evidences indicating that RING105, a novel conserved RING-finger protein with a PA (protease-associated) domain and a PEST sequence, is a ubiquitin ligase for TSSC5 that can function in concert with the ubiquitin-conjugating enzyme UbcH6. The polyubiquitin target site on TSSC5 was mapped to a region i... | SIGNOR-271551 |
P33076 | P14316 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.525 | In addition to IRF-1, IRF-2, another member of the IRF family, also activates the human CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays. | SIGNOR-271681 |
P09874 | P78527 | 0 | phosphorylation | down-regulates activity | 0.525 | Therefore, through its interaction with Ku70/80 in the presence of dsDNA , DNA-PK phosphorylated PARP-1 at its catalytic CTD. | SIGNOR-280093 |
P23769 | P31749 | 0 | phosphorylation | down-regulates | 0.524 | We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity | SIGNOR-135614 |
P04637 | P12931 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.524 | We recently found that ISGylation of the p53 tumor suppressor is an important novel mechanism to control its stability. Here we identified that Isg15-dependent regulation of p53 can be enhanced by different oncogenes. We further show that the Src-mediated phosphorylation of p53 on Tyr126 and Tyr220 has a positive effec... | SIGNOR-276668 |
P84022 | Q14974 | 0 | relocalization | up-regulates | 0.524 | Here we show that the isolated smad 3 mh1 domain displays significant specific binding to importin beta. we propose that activation of all of the pathway-specific smad proteins (smads 1, 2, 3, 5, 8, and 9) exposes the conserved nls motif, which then binds directly to importin beta and triggers nuclear translocation. | SIGNOR-78191 |
Q12802 | Q03113 | 0 | binding | up-regulates activity | 0.524 | These data suggest that G12 is an upstream activator of AKAP-Lbc in the Rho signaling pathway. | SIGNOR-278882 |
P00533 | Q96CW1 | 0 | relocalization | down-regulates | 0.524 | The removal of the epidermal growth factor receptor (egfr) from the cell surface by endocytosis is triggered by receptor activation, but many facets of egfr trafficking remain unresolvedthe ap-2 complex is involved in the internalization of activated egfr. | SIGNOR-185124 |
Q9H2U1 | Q99836 | 0 | binding | up-regulates activity | 0.524 | We further showed that both DHX9 and DHX36 are localized within the cytosol and are directly bound to the Toll-interleukin receptor domain of MyD88 via their helicase-associated domain 2 and DUF domains. This study demonstrates that DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of pDCs and suggest... | SIGNOR-260956 |
P55011 | O95747 | 0 | phosphorylation | up-regulates | 0.524 | The secretory na-k-cl cotransporter nkcc1 is activated by secretagogues through a phosphorylation-dependent mechanism. three phosphoacceptor sites were identified in the n-terminal domain of the protein (at thr184, thr189, and thr202) none of these residues occurs in the context of strong consensus sites for known se... | SIGNOR-90927 |
Q16665 | Q9Y2N7 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.524 | None of the long HIF-3α variants was capable of efficient induction of an HRE reporter in overexpression experiments, but instead inhibited the transcriptional activation of the reporter by HIF-1 and HIF-2. | SIGNOR-261615 |
P38405 | P29275 | 0 | binding | up-regulates activity | 0.524 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256910 |
P46527 | P27348 | 0 | binding | down-regulates | 0.524 | 14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. | SIGNOR-88300 |
Q13043 | P26927 | 0 | phosphorylation | up-regulates | 0.524 | We directly show that okadaic acid induces phosphorylation in the activation loop of mst, and, once phosphorylated, mst is rapidly translocated to the nucleus. when thr183 in mst1 was mutated to ala, no band could be detected by oa treatment,2 indicating that thr183 was the site of phosphorylation. | SIGNOR-114289 |
Q9H1A4 | P53350 | 0 | phosphorylation | up-regulates | 0.524 | Our analysis revealed an unexpected and unprecedented complexity of mitotic phosphorylation sites and suggests that other kinases than cdk1 and plk1 also contribute to apc phosphorylation. | SIGNOR-119881 |
P63096 | P30872 | 0 | binding | up-regulates activity | 0.524 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256679 |
Q13950 | P56524 | 0 | deacetylation | down-regulates activity | 0.524 | HDAC4 and HDAC5 deacetylate Runx2, allowing the protein to undergo Smurf-mediated degradation | SIGNOR-227547 |
Q01196 | Q03112 | 0 | binding | down-regulates activity | 0.524 | The results that we present here support this model and show that EVI1 interacts with and inhibits RUNX1. As for GATA1, EVI1 seems to repress RUNX1 function by interacting specifically with its DNA-binding domain Runt, leading to destabilization and dissolution of the DNA-RUNX1 complex. | SIGNOR-255716 |
Q05397 | Q14289 | 0 | phosphorylation | up-regulates | 0.524 | Activated rock phosphorylates fak on ser732, which is essential for phosphorylation of tyr407 and for cell migration. We further show that pyk2 is activated by vegf-induced clustering of integrin v 3 and is responsible for the phosphorylation of tyr407. | SIGNOR-147070 |
P56817 | Q9UK22 | 0 | binding | down-regulates quantity by destabilization | 0.523 | SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. we found that overexpression of Fbx2 in the primar... | SIGNOR-271904 |
P08151 | P23443 | 0 | phosphorylation | up-regulates | 0.523 | In this study, we found that an activated mtor/s6k1 pathway promotes gli1 transcriptional activity and oncogenic function through s6k1-mediated gli1 phosphorylation at ser84, which releases gli1 from its endogenous inhibitor, sufu. | SIGNOR-196756 |
P45985 | P21333 | 0 | binding | up-regulates activity | 0.523 | We used Filamin-A-deficient cells to show that Filamin A enhances MKK7 activation and is important for synergistic stress-induced JNK activation in vivo. Thus Filamin A is a novel member of the group of scaffold proteins whose function is to link two MAPKKs together and promote JNK activation. The present study provide... | SIGNOR-260629 |
Q9BZS1 | P84022 | 0 | null | up-regulates | 0.523 | The TCR, IL-2R, and TbetaR must all be stimulated to induce Foxp3 + Tregs. Failure to engage any one of these receptors prevents the generation of Foxp3 + Tregs | SIGNOR-254363 |
Q14203 | P53350 | 0 | phosphorylation | up-regulates | 0.523 | Plk1-mediated phosphorylation of p150(glued) at ser-179 positively regulates its accumulation at the nuclear envelope during prophase. | SIGNOR-167281 |
P60953 | P63096 | 0 | binding | up-regulates activity | 0.523 | These findings indicate that both G alpha(i) and G beta gamma stimulate Rac and Cdc42 pathways with lysophosphatidic acid-induced cell spreading on fibronectin | SIGNOR-256531 |
P19793 | P27361 | 0 | phosphorylation | down-regulates activity | 0.523 | In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate ... | SIGNOR-88662 |
Q96A00 | P17252 | 0 | phosphorylation | up-regulates activity | 0.523 | A major kinase for GPCR‐induced CPI‐17 phosphorylation is PKC which is activated by the PLCbeta‐produced signaling messenger diacylglycerol (DAG). It phosphorylates CPI‐17 at Thr38 residue that directly docks at the active site of MLCP, thereby inhibiting its activity and promoting an increase of phosphorylation of myo... | SIGNOR-249259 |
P50148 | P30550 | 0 | binding | up-regulates activity | 0.523 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257372 |
Q15717 | Q16539 | 0 | phosphorylation | up-regulates | 0.523 | P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. | SIGNOR-186135 |
Q4VCS5 | O95835 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.523 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275843 |
P23458 | Q8N6P7 | 0 | binding | up-regulates | 0.523 | Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. | SIGNOR-124489 |
Q14457 | Q9HD26 | 0 | binding | up-regulates | 0.523 | Npist binds beclin 1 by a ccd | SIGNOR-171896 |
P15927 | P54727 | 0 | binding | up-regulates activity | 0.523 | GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). TC-NER is initiated by RNA polymerase stalled at a lesion with the help of TC-NER specific factors CSA, CSB, and XAB2. Both pathways require the core NER factors to complete the excision... | SIGNOR-275699 |
O60674 | P27361 | 0 | phosphorylation | down-regulates | 0.523 | We hypothesize that phosphorylation of ser523 in jak2 by erks 1 and/or 2 or other as-yet-unidentified kinases acts in a negative feedback manner | SIGNOR-146747 |
P04637 | Q99986 | 0 | phosphorylation | up-regulates | 0.523 | Vrk1 phosphorylates murine p53 in threonine 18. This threonine is within the p53 hydrophobic loop (residues 13-23) required for the interaction of p53 with the cleft of its inhibitor mdm-2. | SIGNOR-81222 |
P45984 | P63000 | 0 | binding | up-regulates | 0.523 | We show that rac1 activates jnk2 that in turn phosphorylates beta-catenin on critical residues and controls its nuclear translocation. | SIGNOR-178265 |
P15172 | P24941 | 0 | phosphorylation | down-regulates | 0.522 | Cyclin e/cdk2 can phosphorylate myod at serine 200, which causes ubiquitination and degradation of this transcription factor during g1, preventing its accumulation and a commitment to differentiation. | SIGNOR-176509 |
Q9BXL7 | P31749 | 0 | phosphorylation | up-regulates activity | 0.522 | Akt phosphorylates S637 and S645 in the linker region of Carma1 | SIGNOR-276621 |
P10275 | Q14192 | 0 | binding | up-regulates | 0.522 | Fhl2 contains a strong, autonomous transactivation function and binds specifically to the ar in vitro and in vivo. | SIGNOR-74703 |
Q5VTR2 | Q13315 | 0 | phosphorylation | up-regulates | 0.522 | E3 ubiquitin ligase, a heterodimeric complex of the ringfinger rfn20/rfn40 is phosphorylated by atm. | SIGNOR-174949 |
Q14344 | P30556 | 0 | binding | up-regulates | 0.522 | These results indicate that ang ii increases endothelial arginase activity/expression through galfa12/13 g proteins coupled to at(1) receptors and subsequent activation of rhoa/rock/p38 mapk pathways leading to endothelial dysfunction. | SIGNOR-171760 |
P43034 | P07900 | 0 | binding | up-regulates quantity by stabilization | 0.522 | The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like protein ... | SIGNOR-252168 |
O95297 | Q06124 | 0 | dephosphorylation | down-regulates | 0.522 | In vitro, tyrosine-phosphorylated pzr was efficiently dephosphorylated by the full-length form of shp-2 but not by its sh2 domain-truncated form. The coexisting binding and dephosphorylation of pzr by shp-2 may function to terminate signal transduction initiated by pzr and shp-2 and to set a threshold for the signal tr... | SIGNOR-75220 |
P05771 | O15530 | 0 | phosphorylation | up-regulates | 0.522 | One of the most studied events controlled by ptdins(3,4,5)p3, comprises the activation of a of agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regula... | SIGNOR-126069 |
P16220 | Q13315 | 0 | phosphorylation | down-regulates | 0.522 | Individual ala substitutions at thr-100, ser-111, or ser-121 inhibited atm-catalyzed phosphate incorporationatm phosphorylated creb in vitro and in vivo in response to ionizing radiation (ir) and h(2)o(2) on a stress-inducible domain. Ir-induced phosphorylation of creb correlated with a decrease in creb transactivation... | SIGNOR-124051 |
Q2TAZ0 | Q9Y484 | 0 | binding | up-regulates activity | 0.522 | WIPI4 interacts with ATG2, AMPK and ULK1. Upon starvation and AMPK activation, WIPI4-ATG2 dissociates from AMPK and ULK1 and localizes at nascent autophagosomes, potentially supporting further autophagosome maturation. | SIGNOR-268483 |
O43306 | P04899 | 0 | binding | down-regulates activity | 0.522 | Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 | SIGNOR-278078 |
Q00987 | Q13535 | 0 | phosphorylation | down-regulates activity | 0.522 | We found that a major kinase responsible for s407 phosphorylation is atrs407 phosphorylation of mdm2 by atr reduces mdm2-dependent export of p53 from nuclei to cytoplasm. | SIGNOR-119546 |
P20393 | Q9UBK2 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.522 | Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and skeletal muscle of mice. PGC-1alpha stimulates the expression of clock genes, notab... | SIGNOR-268030 |
Q8N726 | Q13207 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.522 | TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et a... | SIGNOR-249594 |
Q9NR28 | Q16611 | 0 | relocalization | up-regulates | 0.522 | Bax and/or bak-mediated release of pro-apoptotic mediators including smac/diablo and omi | SIGNOR-118905 |
P32927 | P29350 | 0 | dephosphorylation | down-regulates | 0.522 | However, inhibition of shp2 binding to betac, did not prevent tyrosine phosphorylation of shp2. Interestingly, this same phosphopeptide served as a substrate for the tyrosine phosphatase activity of both shp1 and shp2. | SIGNOR-114597 |
P06737 | Q9Y572 | 0 | binding | up-regulates | 0.522 | Rip3 directly interacts with glycogen phosphorylase (pygl), glutamate ammonia ligase (glul), and glutamate dehydrogenase 1 (glud1). Rip kinase activity is required to enhance the activities of all three enzymes both in vivo and in vitro. | SIGNOR-186939 |
P63000 | Q96BY6 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.522 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260549 |
Q01082 | P36897 | 0 | phosphorylation | up-regulates | 0.522 | This suggests that, upon stimulation with tgf-beta1, phosphorylation of elf could induce a conformational change that reduces its affinity for ankyrin and tropomyosin and facilitates an association with smad3 and smad4 instead. | SIGNOR-97626 |
P61224 | P17612 | 0 | phosphorylation | up-regulates | 0.522 | These results provide a mechanistic explanation for the differential effects of rap1 phosphorylation by pka on effector protein interaction. camp is one among several pathways leading to rap1 activation | SIGNOR-187410 |
P35244 | P54727 | 0 | binding | up-regulates activity | 0.522 | GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). TC-NER is initiated by RNA polymerase stalled at a lesion with the help of TC-NER specific factors CSA, CSB, and XAB2. Both pathways require the core NER factors to complete the excision... | SIGNOR-275700 |
P11168 | P52945 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.522 | In conclusion, Pdx1 confers the expression of pancreatic β-cell-specific genes, such as genes encoding insulin, islet amyloid polypeptide, Glut2, and Nkx6.1. | SIGNOR-255540 |
Q5VWQ8 | P98082 | 0 | binding | up-regulates activity | 0.521 | In prostate cancer cells, DAB2IP was shown to be recruited by the adaptor protein DAB2/DOC2 to promote Ras inactivation and inhibition of MAPK signaling upon receptor stimulation. | SIGNOR-254744 |
O43524 | Q9HBY8 | 0 | phosphorylation | down-regulates activity | 0.521 | Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked p... | SIGNOR-249130 |
Q99835 | P48729 | 0 | phosphorylation | up-regulates | 0.521 | We demonstrate that mammalian Smo (mSmo) is activated through multi-site phosphorylation of its carboxyl-terminal tail by CK1α and GRK2. Phosphorylation of mSmo induces its active conformation and simultaneously promotes its ciliary accumulation. | SIGNOR-174542 |
A1X283 | P12931 | 0 | phosphorylation | up-regulates activity | 0.521 | C-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells|Here, we show that the interaction of noxa1 and tks proteins is dependent on src activity. Interestingly, the abolishment of src-mediated phosphorylation o... | SIGNOR-264705 |
Q14457 | P00533 | 0 | phosphorylation | down-regulates activity | 0.521 | The mechanism by which EGFR suppresses Beclin 1 function involves EGFR interaction with two domains (BH3 and ECD) of Beclin 1; EGFR mediated multisite tyrosine phosphorylation of Beclin 1 on residues Y229, Y233 and Y352; and EGFR mediated alterations in the Beclin 1 interactome (increased binding to the negative regula... | SIGNOR-278357 |
P62834 | P17612 | 0 | phosphorylation | down-regulates activity | 0.521 | Phosphorylation of Rap1A by PKA abolished its binding activity to CRR. a mutant Rap1A(S180E), whose sole PKA phosphorylation residue, Ser-180, was substituted by an acidic residue, Glu, to mimic its phosphorylated form, failed to suppress Ras-dependent Raf-1 activation in COS-7 cells. | SIGNOR-250042 |
Q92900 | Q9HCE1 | 0 | binding | up-regulates activity | 0.521 | MOV10 has been shown to promote mRNA degradation by associating with UPF1, this activity requires the helicase activity of MOV10. | SIGNOR-261139 |
P60953 | Q8WWN8 | 0 | gtpase-activating protein | down-regulates activity | 0.521 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260457 |
P48454 | P0DP24 | 0 | binding | up-regulates | 0.521 | Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. | SIGNOR-266324 |
Q12933 | O95819 | 0 | phosphorylation | down-regulates quantity | 0.521 | A key finding of our study is that HGK induces lysosomal degradation of TRAF2 by directly phosphorylating TRAF2 Ser35.|Conversely, TRAF2 levels were decreased by ectopically expressed HGK in an overexpression system (XREF_FIG). | SIGNOR-279536 |
O95295 | O43567 | 0 | polyubiquitination | up-regulates activity | 0.521 | RNF13 directly interacted with snapin, a SNAP-25-interacting protein. Interestingly, snapin was ubiquitinated by RNF13 via the lysine-29 conjugated polyubiquitin chain, which in turn promoted the association of snapin with SNAP-25. Consistently, we found an attenuated interaction between snapin and SNAP-25 in the RNF1... | SIGNOR-272044 |
Q5JWF2 | P32245 | 0 | null | up-regulates activity | 0.521 | We hypothesize that XLαs may be involved in this regulatory loop by coupling to melanocortin receptors 3 and 4 in the hypothalamus. | SIGNOR-253067 |
O43524 | Q16539 | 0 | phosphorylation | up-regulates | 0.521 | Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin | SIGNOR-177927 |
Q9BXW9 | Q9NS91 | 0 | ubiquitination | up-regulates activity | 0.521 | In summary, these findings suggest a model, where Rad18 promotes monoubiquitination of FANCD2, and associates with a functional complex involving Rad51, BRCA2, and FANCD2 in the repair of CPT induced stalled or collapsed forks.|In this study we focused on the role of Rad18 mediated activation of FANCD2 and its function... | SIGNOR-278712 |
Q9NRA0 | P27361 | 0 | phosphorylation | up-regulates | 0.521 | Sphingosine kinase type 2 activation by erk-mediated phosphorylation. site-directed mutagenesis indicated that hsphk2 is phosphorylated on ser-351 and thr-578 by erk1 | SIGNOR-153387 |
P21731-2 | P17252 | 0 | phosphorylation | down-regulates activity | 0.521 | These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes ... | SIGNOR-274092 |
P63092 | P32245 | 0 | binding | up-regulates activity | 0.521 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268707 |
P55072 | O00124 | 0 | relocalization | down-regulates quantity | 0.521 | The human protein named Rep8 or Ubxd6 as a new cofactor of p97. Rep8 tethers p97 to the ER membrane for efficient ER-associated degradation. | SIGNOR-261002 |
P63092 | P34969 | 0 | binding | up-regulates activity | 0.521 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256783 |
P42338 | P21860 | 0 | binding | up-regulates | 0.521 | Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. | SIGNOR-146864 |
P07101 | P49137 | 0 | phosphorylation | up-regulates activity | 0.52 | MAPKAP-K2 phosphorylates both Ser19 and Ser40 of TH. Tyrosine hydroxylase (TH) has been reported to require binding of 14-3-3 proteins for optimal activation by phosphorylation. | SIGNOR-250149 |
P11441 | Q9UKV5 | 0 | polyubiquitination | down-regulates activity | 0.52 | USP13 and gp78 control ubiquitination of Ubl4A.These data suggest that USP13 and gp78 play antagonizing roles in regulation of Ubl4A ubiquitination: While gp78 assembles ubiquitin chains on Ubl4A, USP13 antagonizes this activity to limit Ubl4A ubiquitination.Ubiquitination of Ubl4A preferentially occurs on Lys48. We id... | SIGNOR-272856 |
O15151 | O14757 | 0 | phosphorylation | down-regulates activity | 0.52 | MDMX is a direct substrate for Chk1 and Chk2 in vitro. Phosphorylation of MDMX leads to increased binding to MDM2 and more efficient ubiquitination, providing an explanation for the enhanced degradation of MDMX after DNA damage. | Western blot showed that Chk1 modified S342 and S367, but with strong preference for S342... | SIGNOR-250770 |
P07320 | P02511 | 0 | binding | up-regulates activity | 0.52 | Human gamma-crystallins are long-lived, unusually stable proteins of the eye lens exhibiting duplicated, double Greek key domains. The lens also contains high concentrations of the small heat shock chaperone alpha-crystallin, which suppresses aggregation of model substrates in vitro. Mature-onset cataract is believed t... | SIGNOR-253621 |
O95622 | P19086 | 0 | binding | down-regulates activity | 0.52 | Activated a z inhibits the activity of type I and type V adenylyl cyclases. | SIGNOR-278045 |
P14373 | Q9UJ55 | 0 | binding | up-regulates activity | 0.52 | MAGE proteins are a family of proteins that contain a conserved domain known as the MAGE homology domain. Recently, we showed that MAGE proteins function biochemically to bind to and enhance the activity of E3 RING ubiquitin ligases. The E3 RING ubiquitin ligase TRIM27 was identified as a major binding partner of MAGE-... | SIGNOR-253513 |
P04637 | O14920 | 0 | phosphorylation | up-regulates activity | 0.52 | Here , we show that IKKbeta modulates the activity of p53 in response to glutamine depletion to promote cancer cell adaptation .|Taken together, these results indicate that IKK\u03b2 phosphorylates p53 on Ser392 as an early response to glutamine deprivation and possibly later facilitates its phosphorylation at Ser15 an... | SIGNOR-278516 |
P15923 | P49137 | 0 | phosphorylation | up-regulates | 0.52 | Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2 | SIGNOR-166643 |
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