IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O14746 | Q12986 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.52 | NFX1-123 positively regulated hTERT expression, as its knockdown decreased hTERT mRNA levels and telomerase activity and its overexpression increased telomerase activity. NFX1-123 was found to interact with cytoplasmic poly(A) binding proteins (PABPCs), and together they synergistically augmented expression from the hT... | SIGNOR-261050 |
Q9UHD2 | P36406 | 0 | binding | up-regulates activity | 0.519 | TRIM23 interacts with TBK1 and p62. TRIM23 GTPase activates TBK1 to phosphorylate p62. Biochemical characterization showed that TRIM23 binds with its C-terminal ARF domain to the N-terminal KD of TBK1, and that GTP hydrolysis activity of the ARF stimulates TBK1-mediated phosphorylation of p62 at S403 in its ubiquitin-a... | SIGNOR-266654 |
O00327 | Q9UBK2 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.519 | Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and skeletal muscle of mice. PGC-1alpha stimulates the expression of clock genes, notab... | SIGNOR-268031 |
O95622 | P08754 | 0 | binding | down-regulates activity | 0.519 | Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 | SIGNOR-278076 |
P35222 | Q12913 | 0 | dephosphorylation | up-regulates activity | 0.519 | Our data demonstrate that CD148 promotes E-cadherin cell adhesion by regulating Rac1 activity, concomitant with modulation of p120, \u03b2-catenin, and Src tyrosine phosphorylation, and that this effect requires E-cadherin and p120 association.|Taken together, it is likely that CD148 dephosphorylation of \u03b2-catenin... | SIGNOR-276992 |
P46937 | Q9UDY2 | 0 | binding | down-regulates | 0.519 | The Crumbs complex component AMOT co-localizes with MST1_ 2, LATS1_ 2 and YAP in a complex at the tight junction to control cell growth. Zona occludens-2 (ZO-2) in the tight junction, and a-catenin, b-catenin, or PTPN14 in the adherence junction, also bind to YAP_TAZ. | SIGNOR-230754 |
P55957 | P04637 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.519 | Bid is a p53 primary-response gene. | SIGNOR-140248 |
P49715 | P35638 | 0 | transcriptional regulation | down-regulates quantity | 0.519 | We find that expression of CHOP, a nuclear protein that dimerizes avidly with C/EBP isoforms alpha and beta and directs the resulting heterodimer away from classic C/EBP-binding sites, markedly inhibits this differentiation process. | SIGNOR-255913 |
P15173 | P50461 | 0 | binding | up-regulates activity | 0.519 | we found that nuclear MLP functions through a physical interaction with the muscle basic helix-loop-helix (bHLH) transcription factors MyoD, MRF4, and myogenin. we propose that it serves as a cofactor for the myogenic bHLH proteins by increasing their interaction with specific DNA regulatory elements. | SIGNOR-241113 |
P05023 | P28482 | 0 | phosphorylation | down-regulates activity | 0.519 | Parathyroid hormone (PTH) inhibits Na+,K+-ATPase activity through protein kinase C- (PKC) and extracellular signal-regulated kinase- (ERK) dependent pathways and increases serine phosphorylation of the α1-subunit. These results suggest that PTH regulates Na(+),K(+)-ATPase by PKC and ERK-dependent alpha(1)-subunit phos... | SIGNOR-262940 |
P09874 | P28482 | 0 | phosphorylation | up-regulates | 0.519 | Parp1 phosphorylation by erk1/2 is required for maximal parp-1 activation after dna damage. S372a and t373a mutations impaired parp-1 activation. | SIGNOR-146224 |
Q13972 | P17612 | 0 | phosphorylation | up-regulates | 0.519 | Phosphorylation of serine 916 of ras-grf1 contributes to the activation of exchange factor activity by muscarinic receptors. | SIGNOR-73202 |
Q8N2W9 | Q05513 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.519 | In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4.FIEL1 targets PIAS4 using a double locking mechanism that is facilitated by the kinases PKCzeta ... | SIGNOR-275513 |
Q9UBP0 | P53990 | 0 | relocalization | up-regulates activity | 0.519 | Our results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. Thus, we reveal a novel cellular role for MT severing and identify a mechanism by which endosomal recycling can be coordinated with the degradative machinery. | SIGNOR-269047 |
Q2M2Z5 | P53350 | 0 | phosphorylation | up-regulates | 0.519 | Here, we identify a novel centrosomal substrate of plk1, kizuna (kiz), depletion of which causes fragmentation and dissociation of the pericentriolar material from centrioles at prometaphase, resulting in multipolar spindles. Plk1 maintains the integrity of the spindle poles by phosphorylating kiz. | SIGNOR-149630 |
Q96J92 | O95198 | 0 | binding | down-regulates quantity by destabilization | 0.519 | We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms. The direct interaction of KLHL2 with WNKs was confirmed on fluorescence correlation spectroscopy. Co-expression of KLHL2 and Cullin3 decreased the abundance of WNK1, WNK3 and WNK4 within HEK293T cells, and a significant increas... | SIGNOR-272118 |
P35222 | Q08050 | 0 | binding | up-regulates activity | 0.519 | Nuclear FoxM1 then directly interacted with nuclear β‐catenin, which released β‐catenin from ICAT and enhanced recruitment of β‐catenin to the promoter of Wnt target gene, hence increasing the expression of Wnt target gene. | SIGNOR-277211 |
Q00613 | P49137 | 0 | phosphorylation | down-regulates activity | 0.519 | A potential mechanism for MK2-induced HSF1 inactivation is suggested by the findings that phosphorylation of serine 121 enhances HSF1 binding to HSP90, a major repressor of HSF1.|Phosphorylation of HSF1 by MAPK activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. | SIGNOR-279541 |
O15294 | P49841 | 0 | phosphorylation | up-regulates activity | 0.518 | But OGT activity is modulated by GSK3beta (XREF_FIG) and GSK3beta activity is known to oscillate through Ser9 phoshorylation.|Here, we found that OGT is phosphorylated at serines 3 or 4 by GSK3beta and that O GlcNAcylation of OGT also occurs on the same or neighboring serine residues, suggesting interacting phosphoryla... | SIGNOR-279528 |
P06748 | P06493 | 0 | phosphorylation | down-regulates activity | 0.518 | However, under the experimental conditions used here, the t199 residue was the most likely candidate to be phosphorylated by cyclin b/cdc2 these results strongly support the concept that the rna binding activity of b23.1 is inactivated by cyclin b/cdc2-mediated phosphorylation. | SIGNOR-89605 |
Q92793 | O15111 | 0 | binding | up-regulates | 0.518 | Ikk-alpha interacts with creb-binding protein and in conjunction with rel a is recruited to nf-kappab-responsive promoters and mediates the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone h3. | SIGNOR-101539 |
P09471 | P14416 | 0 | binding | up-regulates activity | 0.518 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256980 |
P01100 | P17612 | 0 | phosphorylation | up-regulates activity | 0.518 | Human c-Fos protein is phosphorylated in vitro by PKA. phosphorylation of Fos occurs at serine residue 362. Modification of the Fos protein by phosphorylation with PKA then allows it to act as a regulator of its own synthesis by downregulating fos gene expression at a transcriptional level | SIGNOR-250356 |
P46531 | P80370 | 0 | binding | down-regulates activity | 0.518 | Moreover, the interaction of DLK1 with NOTCH1 caused an inhibition of basal NOTCH signaling in preadipocytes and mesenchymal multipotent cells. In this work, we demonstrate, for the first time, that DLK2 interacts with itself, with DLK1, and with the same NOTCH1 receptor region as DLK1 does. We demonstrate also that th... | SIGNOR-172830 |
Q04206 | P42224 | 0 | binding | down-regulates | 0.518 | Acetylated stat1 is able to interact with nf-kappab p65. As a consequence, p65 dna binding, nuclear localization, and expression of anti-apoptotic nf-kappab target genes decrease. | SIGNOR-144561 |
Q8N122 | P28482 | 0 | phosphorylation | up-regulates activity | 0.518 | We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, ... | SIGNOR-188916 |
O14654 | P06213 | 0 | phosphorylation | up-regulates activity | 0.518 | The binding of insulin to the subunit of IR not only concentrates insulin at its site of action, but also induces conformational changes in the receptor, which in turn stimulates the tyrosine kinase activity intrinsic to the _ subunit of the IR and triggers the signaling cascades (Fig. 3). Insulin receptors trans phos... | SIGNOR-217897 |
P61586 | P17612 | 0 | phosphorylation | down-regulates activity | 0.518 | PKA phosphorylates RhoA on Ser188. the addition of a negative charge to Ser188 is sufficient to diminish both RhoA activation and activity within the context of a cell. | SIGNOR-250047 |
P00751 | P08603 | 0 | binding | down-regulates activity | 0.518 | As a regulator of the alternative pathway, FH binds to C3b and inhibits the binding of factor B to C3b, acts as a cofactor for the factor I-mediated cleavage of C3b to iC3b (cofactor activity), and accelerates the decay of C3bBb, the alternative pathway C3 convertase (decay-accelerating activity) | SIGNOR-252142 |
P98177 | P24941 | 0 | phosphorylation | down-regulates | 0.518 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity | SIGNOR-183655 |
P55211 | Q9Y243 | 0 | phosphorylation | down-regulates | 0.518 | Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity | SIGNOR-61565 |
Q9BQ95 | Q8IWR1 | 0 | binding | down-regulates activity | 0.518 | In this study, we showed that one of the TRIM family ubiquitin ligases, TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. The B-box and RING domains of TRIM59 are important for interaction with ECSIT.|ECSIT enhances IPS-1-mediated IFN-Beta promoter activation.|Lucife... | SIGNOR-260369 |
P00519 | Q4KMG0 | 0 | binding | up-regulates activity | 0.518 | Abl binds a proline-rich motif in cdo via its sh3 domain, and these regions of abl and cdo are required for their promyogenic effects. Cdo is important for full abl kinase activity | SIGNOR-185762 |
Q92974 | O96013 | 0 | phosphorylation | down-regulates activity | 0.518 | PAK4 specifically phosphorylates GefH1, and this is thought to inhibit its ability to activate Rho, consequently inhibiting stress fiber formation. | SIGNOR-279245 |
P15976 | Q01543 | 0 | binding | up-regulates activity | 0.518 | On the other hand, our data demonstrate that FLI-1 also interacts with GATA-1. However, FLI-1 does not repress but enhances GATA-1 activity. | SIGNOR-256045 |
Q03167 | P61812 | 0 | binding | up-regulates | 0.518 | Betaglycan binds tgf-b isoforms with high affinity and increases the functional interaction between tgf-b and its type ii and type i signalling receptors. | SIGNOR-76473 |
P01116 | Q5VWQ8 | 0 | gtpase-activating protein | down-regulates activity | 0.518 | The GAP domain of DAB2IP is homologous to other Ras-GAPs, such as GAP120 and neurofibromin (NF1), and can stimulate the GTPase activity of RAS proteins both in vitro and in cancer cell lines. DAB2IP is able to stimulate in vitro and in vivo the GTPase activity of RAS proteins (H-Ras, K-Ras, and N-Ras) facilitating GTP ... | SIGNOR-254746 |
Q9GZQ8 | Q9BQS8 | 0 | binding | up-regulates activity | 0.517 | The preferential binding to LC3A and -B was confirmed in vivo by co-immunoprecipitation experiments of Myc-tagged FYCO1 and GFP fusions of human ATG8 family pro-teins expressed in HEK293 cells (Fig. 2B). GFP-LC3A and GFP-LC3B were efficiently co-precipitated with Myc-FYCO1,whereas GFP-LC3C, GFP-GABARAP, GFP-GABARAPL1 a... | SIGNOR-260597 |
P50148 | Q9NS75 | 0 | binding | up-regulates activity | 0.517 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257024 |
P78347 | Q06187 | 0 | phosphorylation | up-regulates activity | 0.517 | These residues, tyr248, tyr357, and tyr462, were also found to be the major sites for btk-dependent phosphorylation of bap/tfii-i in vivo. Residues tyr357 and tyr462 are contained within the loop regions of adjacent helix-loop-helix-like repeats within bap/tfii-i. Mutation of either tyr248, tyr357, or tyr462 to phenyla... | SIGNOR-108346 |
P04628 | Q92765 | 0 | binding | down-regulates | 0.517 | We and others demonstrated that fzb-1 blocks wnt-1 and xwnt-8 signaling in xenopus embryos, | SIGNOR-51762 |
P40763 | P23468 | 0 | dephosphorylation | down-regulates activity | 0.517 | Transfection of wild-type PTPRD resulted in the specific dephosphorylation of STAT3 at tyrosine 705, a residue that must be phosphorylated for STAT3 to be active | SIGNOR-248442 |
O14920 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.517 | Activation of IkappaB kinase beta by protein kinase C isoforms. | Interestingly, recombinant active zetaPKC and alphaPKC are able to stimulate in vitro the activity of IKKbeta but not that of IKKalpha. In addition, evidence is presented here that recombinant zetaPKC directly phosphorylates IKKbeta in vitro, involving ... | SIGNOR-249015 |
Q9HBH9 | P27361 | 0 | phosphorylation | up-regulates | 0.517 | Erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity. | SIGNOR-48355 |
Q99075 | P08254 | 0 | cleavage | up-regulates | 0.517 | It was concluded that mmp-3 cleaves hb-egf at a specific site in the jm domain and that this enzyme might regulate the conversion of hb-egf from being a juxtacrine to a paracrine/autocrine growth factor. | SIGNOR-83339 |
P27986 | Q13191 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.517 | Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Here it is shown that Cbl-b interacts with and induces ubiquitin conjugation to the p85 regulatory subunit of phosphatidylinositol 3-kinase, an upstream regulator of Vav. | SIGNOR-272583 |
Q00535 | P50613 | 0 | phosphorylation | up-regulates activity | 0.517 | In addition, the Cdk7 substrate, CTD of RNAPII, causes a dose-dependent decline in Cdk5 activation by Cdk7.|Likewise, Cdk7 or cyclin H immunoprecipitate from mouse brain specifically phosphorylates wt Cdk5 at Ser159 and enhances Cdk5 and p25 activity. | SIGNOR-278923 |
O43524 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.517 | Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. | SIGNOR-249684 |
P42684 | P00519 | 0 | phosphorylation | up-regulates | 0.517 | The results show that arg is stabilized in response to 0.1 mm h2o2 by autophosphorylation of y-261, consistent with involvement of the arg kinase function in regulating arg levels. The results further demonstrate that c-abl-mediated phosphorylation of arg on y-261 similarly confers arg stabilization | SIGNOR-134396 |
O95239 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.517 | Using in vitro kinase assays, we found that active AMPK and Aurora B phosphorylated KIF4A at Ser801 and Thr799 respectively in a time-dependent manner (Figure 5D). KIF4A is phosphoregulated by AMPK and Aurora B. Although AMPK phosphorylation increased the ATPase activity of KIF4A, Aurora B phosphorylation resulted in ... | SIGNOR-265992 |
P50148 | Q99500 | 0 | binding | up-regulates activity | 0.517 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257388 |
Q15121 | P31749 | 0 | phosphorylation | up-regulates activity | 0.517 | Protein kinase b/akt binds and phosphorylates ped/pea-15, stabilizing its antiapoptotic action. | SIGNOR-102092 |
P84022 | Q9NYA4 | 0 | dephosphorylation | down-regulates | 0.517 | Here we demonstrate that myotubularin-related protein 4 | SIGNOR-163034 |
O00187 | O75636 | 0 | binding | up-regulates activity | 0.517 | In the lectin pathway, mannose-binding lectin (MBL) and ficolins bind to pathogens and activate MBL-associated serine protease-2 (MASP-2) | SIGNOR-263412 |
Q9UQL6 | Q15139 | 0 | phosphorylation | down-regulates activity | 0.516 | Here, we demonstrate that signaling by protein kinase C (PKC) is sufficient and, in some cases, necessary to drive nuclear export of class II HDAC5 in cardiomyocytes. | SIGNOR-249270 |
P63096 | Q9H3N8 | 0 | binding | up-regulates activity | 0.516 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256672 |
P63092 | P29275 | 0 | binding | up-regulates activity | 0.516 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256767 |
P08754 | Q92633 | 0 | binding | up-regulates activity | 0.516 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256839 |
P63096 | Q99835 | 0 | binding | up-regulates | 0.516 | Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. | SIGNOR-199159 |
O95835 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.516 | Furthermore, ITCH mediated degradation of LATS1 was associated with enhanced cell growth, induction of epithelial-mesenchymal transition, and increased tumorigenicity.|Ubiquitination of LATS1 catalyzed by ITCH stimulated the proteasomal degradation of LATS1. | SIGNOR-278816 |
P27348 | P48729 | 0 | phosphorylation | down-regulates activity | 0.516 | This protein kinase has been identified as casein kinase Ialpha (CKIalpha) by peptide mapping analysis and sequencing. Among mammalian 14-3-3, only 14-3-3 tau possesses a phosphorylatable residue at the same position (Ser-233), and we show that this residue is also phosphorylated by CKI. In addition, we show that 14-3-... | SIGNOR-250795 |
Q05193 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.516 | Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates dynamin I on Ser 774 and Ser 778 in vitro, which are identical to its endogenous phosphorylation sites in vivo. Cdk5 antagonists and expression of dominant-negative Cdk5 block phosphorylation of dynamin I, but not of amphiphysin or AP180, in nerve termi... | SIGNOR-250661 |
O14939 | P00533 | 0 | phosphorylation | up-regulates activity | 0.516 | Using transiently transfected human embryonic kidney fibroblasts (HEK293), we demonstrate here that PLD1 activity, and to a lesser extent PLD2 activity, is stimulated in response to epidermal growth factor (EGF). PLD2, but not PLD1, associates with the EGF receptor in a ligand-independent manner and becomes tyrosine-ph... | SIGNOR-251095 |
Q12852 | Q9UQF2 | 0 | binding | down-regulates | 0.516 | Jip inhibits dlk dimerization. | SIGNOR-109046 |
Q4VCS5 | Q9NRM7 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.516 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275846 |
P11511 | P03372 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.516 | By binding to S1, ERalpha down-regulates the aromatase promoter activity. | SIGNOR-271683 |
P63092 | Q01718 | 0 | binding | up-regulates activity | 0.516 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268694 |
Q04206 | P17612 | 0 | phosphorylation | up-regulates | 0.516 | The transcriptional activity of nf-kappa b is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase a (pka). | SIGNOR-58972 |
O14641 | Q13145 | 0 | binding | up-regulates | 0.516 | Bmp-2 mediates phosphorylated smad1 (psmad1) or, with loss of bmprii, psmad3-dependent recruitment of disheveled (dvl) to promote rhoa-rac1 signaling necessary for motility. | SIGNOR-23037 |
Q5BJF6 | Q96L34 | 0 | phosphorylation | up-regulates activity | 0.516 | Collectively, our data indicate that MARK4 interacts with ODF2 in vivo and phosphorylates ODF2 in vitro.|Collectively, our data support the model that MARK4 promotes ciliogenesis by acting upstream of ODF2. | SIGNOR-278961 |
P41208 | O14965 | 0 | phosphorylation | up-regulates | 0.516 | Our studies show that aurora a phosphorylates centrin at serine 170 in vitro and that the serine 170 phosphorylation affects the stability of centrin by regulating its interaction with apc/c. finally we demonstrated that phosphorylation of centrin serine 170 is an absolute requirement for aurora a-mediated centriole a... | SIGNOR-174686 |
P40763 | O14522 | 0 | dephosphorylation | down-regulates activity | 0.516 | Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. | SIGNOR-263981 |
Q14247 | P18031 | 0 | dephosphorylation | up-regulates activity | 0.516 | We conclude that Mena INV promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B. | SIGNOR-277027 |
P24844 | Q5VT25 | 0 | phosphorylation | up-regulates | 0.516 | More than a dozen kinases have been reported to phosphorylate the rlcs of nm ii (fig. 2), including myosin light chain kinase (mlck;also known as mylk), rho-associated, coiled coil-containing kinase (rock), citron kinase, leucine zipper interacting kinase (zipk;also known as dapk3) and myotonic dystrophy kinase-related... | SIGNOR-188781 |
P16949 | Q13554 | 0 | phosphorylation | down-regulates | 0.515 | Stimulation via cd2 activated multiple signal transduction pathways, resulting in phosphorylation of distinct sites of stathmin. Ser16 of recombinant human stathmin was phosphorylated also by purified cam kinase ii, and in vivo, cam kinase ii activity was indeed stimulated in cd2-triggered jurkat cells. | SIGNOR-59358 |
Q15796 | Q9GZU7 | 0 | dephosphorylation | down-regulates activity | 0.515 | SCP1 Dephosphorylates Smad2/3 in the Linkers|MAPK-mediated linker phosphorylation appears to have a dual role in Smad2/3 regulation. Mitogens and hyperactive Ras result in extracellular signal-regulated kinase (ERK)-mediated phosphorylation of Smad3 at Ser-204, Ser-208, and Thr-179 and of Smad2 at Ser-245/250/255 and T... | SIGNOR-248795 |
Q13233 | O15169 | 0 | binding | up-regulates | 0.515 | We found that in contrast to axin, dvl2 activation of jnk does not require mekk1. | SIGNOR-77591 |
P32004 | Q15349 | 0 | phosphorylation | up-regulates activity | 0.515 | Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is ph... | SIGNOR-248949 |
P04637 | P49757 | 0 | binding | up-regulates | 0.515 | Numb can actually interact in vivo with endogenous mdm2 and p53, resulting in a trimeric complex between the three proteins [10]. This interaction appears to regulate the stability of p53, as reduction of numb levels by rna interference (rnai) causes a decrease in the half-life of p53 and consequently a reduction in st... | SIGNOR-178668 |
Q13309 | P31749 | 0 | phosphorylation | down-regulates activity | 0.515 | We further show that Akt1 phosphorylates Skp2 at Ser72, which is required to disrupt the interaction between Cdh1 and Skp2. | SIGNOR-278274 |
P17544 | Q16514 | 0 | binding | up-regulates activity | 0.515 | We show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. | SIGNOR-225249 |
O00303 | P21127 | 0 | phosphorylation | up-regulates activity | 0.515 | EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. | SIGNOR-273133 |
Q9UQC2 | O60674 | 0 | phosphorylation | up-regulates | 0.515 | In vitro, activated jak2 directly phosphorylated specific gab2 tyrosine residues. Mutagenesis studies revealed that gab2 tyrosine 643 (y643) was a major target of jak2 in vitro, and a key residue for jak2-dependent phosphorylation in intact cells. Mutation of gab2 y643 inhibited g-csf-stimulated erk1/2 activation and s... | SIGNOR-179488 |
O75122 | P49841 | 0 | phosphorylation | down-regulates activity | 0.515 | GSK-3beta directly phosphorylates CLASP2 at Ser533 and Ser537 within the region responsible for the IQGAP1 binding. Phosphorylation of CLASP2 results in the dissociation of CLASP2 from IQGAP1, EB1 and microtubules.| CLASPs were originally identified as CLIP-170-interacting proteins and later found to be required for mi... | SIGNOR-264826 |
O43303 | P24941 | 0 | phosphorylation | down-regulates activity | 0.515 | GST-tagged recombinant CP110 (GST-wt) was robustly phosphorylated by cyclin E/CDK2 (Figure 2A). Expression of a mutant derivative of CP110 refractory to CDK phosphorylation provokes marked polyploidy. We localized the majority (nine of ten) of potential CDK2 phosphorylation sites in CP110 to an amino-terminal fragmen... | SIGNOR-265956 |
P18887 | O96017 | 0 | phosphorylation | up-regulates | 0.515 | Chk2 formed a complex with xrcc1, the ber scaffold protein, and phosphorylated xrcc1 in vivo and in vitro at thr(284). our results are consistent with the phosphorylation of xrcc1 by atm-chk2 facilitating recruitment of downstream ber proteins to the initial damage recognition/excision step to promote ber. | SIGNOR-181816 |
P29323 | P00519 | 0 | phosphorylation | down-regulates | 0.515 | Two-hybrid screens identified regions of abl and arg that bind to the ephb2 and epha4 receptors, suggesting a novel signaling connection involving the two kinase families.The connection between EphB2 and Abl/Arg appears to be reciprocal. Activated EphB2 causes tyrosine phosphorylation of Abl and Arg, and vice versa. In... | SIGNOR-109668 |
P04792 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.515 | Radioactive kinase assays confirmed that PKC\u03b4 phosphorylated Hsp27 at Ser78 and Ser82 ( Fig. 3 B). | SIGNOR-278425 |
P60484 | Q9Y2H9 | 0 | phosphorylation | down-regulates | 0.515 | Mast1 was found to associate to pten. | SIGNOR-138003 |
Q13467 | Q9ULT6 | 0 | ubiquitination | down-regulates quantity | 0.515 | Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. | SIGNOR-260118 |
Q15653 | O43318 | 0 | phosphorylation | down-regulates | 0.515 | Overexpression oftak1together with its activator protein,tak1binding protein 1 (tab1), induced thenucleartranslocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. | SIGNOR-55719 |
O95295 | Q5S007 | 0 | phosphorylation | down-regulates | 0.514 | Lrrk2 phosphorylates snapin and inhibits interaction of snapin with snap-25. these data suggest that lrrk2 may regulate neurotransmitter release via control of snapin function by inhibitory phosphorylation. hreonine 117 of snapin is one of the sites phosphorylated by lrrk2 | SIGNOR-202436 |
P68366 | Q14980 | 0 | binding | up-regulates | 0.514 | Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. | SIGNOR-116788 |
P35226 | Q14157 | 0 | binding | up-regulates activity | 0.514 | We identified UBAP2L as a novel BMI1-interacting protein. UBAP2L, BMI1, RNF2, and PHC1 define a novel Polycomb subcomplex | SIGNOR-261315 |
P00441 | Q13501 | 0 | binding | down-regulates quantity by destabilization | 0.514 | This study provides a novel molecular mechanism by which mutant SOD1 can be recognized by p62 in an ubiquitin-independent fashion and targeted for the autophagy-lysosome degradation pathway. | SIGNOR-262801 |
Q9H2X6 | Q8IUQ4 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.514 | Here we demonstrate that HIPK2 is an unstable protein that colocalizes and interacts with the E3 ubiquitin ligase Siah-1 in unstressed cells. Siah-1 knockdown increases HIPK2 stability and steady-state levels, whereas Siah-1 expression facilitates HIPK2 polyubiquitination, degradation and thereby inactivation. | SIGNOR-276166 |
P78337 | P18146 | 0 | binding | up-regulates activity | 0.514 | GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. | SIGNOR-254916 |
P16220 | P31751 | 0 | phosphorylation | up-regulates | 0.514 | Creb is a nuclear target for activation via the growth factor-dependent ser/thr kinase akt/pkb. When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. | SIGNOR-62253 |
P08151 | Q13627 | 0 | phosphorylation | up-regulates activity | 0.514 | Here, we have used an in vitro kinase assay and phospho-peptide mass spectrometry analysis to identify site(s) of direct phosphorylation of GLI1 by DYRK1A and have determined that DYRK1A phosphorylates GLI1 at Ser408 within its nuclear localization sequence.|The kinase DYRK1A (dual-specificity tyrosine phosphorylation ... | SIGNOR-278930 |
P37840 | P68400 | 0 | phosphorylation | up-regulates | 0.514 | In vitro experiments and two-dimensional phosphopeptide mapping provided further evidence that serine 129 was phosphorylated by ck-1 and ck-2. Moreover, phosphorylation of serine 129 was reduced in vivo upon inhibition of ck-1 or ck-2. These data demonstrate that alpha-synuclein is constitutively phosphorylated within ... | SIGNOR-73807 |
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