IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P30679 | P28335 | 0 | binding | up-regulates activity | 0.503 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257355 |
P22307 | Q2T9J0 | 0 | cleavage | up-regulates activity | 0.503 | Here, we demonstrate that Tysnd1, a previously uncharacterized protein, is responsible both for the removal of the leader peptide from PTS2 proteins and for the specific processing of PTS1 proteins. All of the identified Tysnd1 substrates catalyze peroxisomal β-oxidation. In vitro cleavage of Acox1, Scp2 and prethiola... | SIGNOR-261055 |
Q9UMS6 | Q13418 | 0 | phosphorylation | up-regulates activity | 0.503 | Fourth, ILK dependent phosphorylation of myopodin is found both in vivo and in vitro.|The ILK dependent activation of myopodin provides a novel link between extracellular matrix-integrin-ILK signaling and myopodin tumor suppression. | SIGNOR-279622 |
Q9Y243 | P56279 | 0 | binding | up-regulates | 0.503 | Full-length tcl1 and its isoforms bind to akt / in in vitro kinase assays using gsk-3_ as a substrate, we found that the presence of any of the tcl1 family proteins (tcl1, mtcp1, or tcl1b) as gst fusion proteins significantly enhanced akt-induced gsk-3_ phosphorylation | SIGNOR-81434 |
P01903 | P48382 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.503 | In this report, we correlate the loss of IFN-γ induction of MHC class II genes with the identification of a molecular defect in an essential regulator, namely RFX5. | We have further confirmed this finding by showing that new RFX5 leucine mutants created in vitro are incapable of transactivating a class II promoter, su... | SIGNOR-266228 |
P78426 | P52945 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.503 | In conclusion, Pdx1 confers the expression of pancreatic β-cell-specific genes, such as genes encoding insulin, islet amyloid polypeptide, Glut2, and Nkx6.1. | SIGNOR-255542 |
O95251 | P53350 | 0 | phosphorylation | up-regulates | 0.503 | Here, we show that the interaction between plk1 and hbo1 is mitosis-specific and that plk1 phosphorylates hbo1 on ser-57 in vitro and in vivo. During mitosis, cdk1 phosphorylates hbo1 on thr-85/88, creating a docking site for plk1 to be recruited. Significantly, the overexpression of hbo1 mutated at the plk1 phosphoryl... | SIGNOR-160751 |
P33032 | Q96G30 | 0 | binding | down-regulates activity | 0.502 | We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling. In contrast, MRAP and MRAP2 can reduce MC1R, MC3R, MC4R, and MC5R responsiveness to [Nle4,D-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH). MRAP and MRAP2 can reduce the surface expression... | SIGNOR-252369 |
Q13480 | P06213 | 0 | phosphorylation | up-regulates activity | 0.502 | HGab-1 was phosphorylated by IR at eight tyrosine residues (Y242, Y285, Y373, Y447, Y472, Y619, Y657, and Y689). t Gab-1 is the major binding partner of PI-3 kinase in 3T3L1 cells when stimulated with insulin | SIGNOR-251310 |
O75531 | Q86Y07 | 0 | phosphorylation | down-regulates | 0.502 | We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell | SIGNOR-143368 |
Q13621 | O95747 | 0 | phosphorylation | up-regulates activity | 0.502 | We establish that the SPAK and OSR1 kinases activated by WNK interact with an RFQV motif on NKCC2 and directly phosphorylate Thr95, Thr100, Thr105 and, possibly, Ser91.Using these phosphorylation-specific antibodies we establish that hypotonic low-chloride stimulation induces marked phosphorylation of overexpressed NK... | SIGNOR-276309 |
P20823 | Q9Y463 | 0 | phosphorylation | up-regulates | 0.502 | Mirk phosphorylates hnf1 at amino acid 249mkk3 enhanced mirk kinase activity and the transcriptional activation of hnf1alpha by mirk | SIGNOR-86728 |
P46527 | Q04917 | 0 | binding | down-regulates | 0.502 | 14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. | SIGNOR-109771 |
O75122 | P00519 | 0 | phosphorylation | up-regulates quantity | 0.502 | We find that Abl binds to and phosphorylates CLASP2 in response to extracellular signals such as serum or PDGF. | SIGNOR-279580 |
P02686 | P27361 | 0 | phosphorylation | down-regulates | 0.502 | Phosphorylation decreased the ability of mbp to polymerize actin and to bundle actin filaments but had no effect on the dissociation constant of the mbp-actin complex or on the ability of ca2+-calmodulin to dissociate the complex. The most significant effect of phosphorylation on the mbp-actin complex was a dramatic re... | SIGNOR-143481 |
Q96EB6 | O43781 | 0 | phosphorylation | up-regulates activity | 0.502 | DYRK1A and DYRK3 directly phosphorylate SIRT1 at Thr (522), promoting deacetylation of p53.|DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. | SIGNOR-279705 |
P61586 | Q3KRB8 | 0 | gtpase-activating protein | down-regulates activity | 0.502 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260467 |
P13807 | Q16821 | 0 | dephosphorylation | up-regulates | 0.502 | In skeletal muscle, the activation of glycogen synthase by insulin involves the dephosphorylation of serine residues that are phosphorylated by gsk3 and dephosphorylated by the glycogen-associated form of protein phosphatase-l (pp1g). | SIGNOR-37301 |
P18031 | P06493 | 0 | phosphorylation | up-regulates activity | 0.502 | Cdk1-cyclin B1 directly phosphorylates PTP1B at serine 386 in a kinase assay. Recombinant Plk1 phosphorylates PTP1B on serine 286 and 393 in vitro, however, it requires a priming phosphorylation by Cdk1 at serine 386 highlighting a novel co-operation between Cdk1 and Plk1 in the regulation of PTP1B.|Finally, phosphoryl... | SIGNOR-272970 |
Q07820 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.502 | Mule was identified as Mcl-1 ubiquitin ligase E3 to promote Mcl-1 degradation via the proteasomal pathway [46]. We found that knockdown of Mule (Fig. 4C) but not β-TRCP or FBXW7 (data not shown) prevented Mcl-1 downregulation caused by PKCη depletion. | SIGNOR-261909 |
Q15831 | P17612 | 0 | phosphorylation | up-regulates activity | 0.502 | Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. | SIGNOR-250055 |
Q16584 | Q7Z6J0 | 0 | binding | up-regulates | 0.502 | Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks. | SIGNOR-97006 |
O00327 | P51449 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.502 | As RORs function as transcriptional activators and their expression correlates with histone acetylation and chromatin accessibility, RORs are thought to function as positive regulators of Bmal1 expression at its peak levels, whereas REV-ERBs block ROR and negatively regulate Bmal1 at the trough of its expression. | SIGNOR-268004 |
P63092 | P50406 | 0 | binding | up-regulates activity | 0.502 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256801 |
P17275 | Q16539 | 0 | phosphorylation | up-regulates | 0.502 | These results clearly demonstrate that phosphorylation by p38 kinase is essential for the regulation of dmp1 transcription by junb and p300. phosphorylation of junb at ser-79 was found to be essential for its interaction with p300. | SIGNOR-127545 |
Q04206 | Q13315 | 0 | phosphorylation | down-regulates activity | 0.502 | Interestingly, another group has identified that in the VP-16 induced NF-\u03baB activation, ATM binds to RelA directly and phosphorylates RelA on Ser 547, a post-translational modification that represses a subset of NF-\u03baB-dependent genes ( xref ).|Our findings that ablation of ATM reduces RelA serine 276 phosphor... | SIGNOR-279006 |
P08581 | P17706 | 0 | dephosphorylation | down-regulates | 0.501 | We have identified ptp1b and tcptp as negative regulators of the hepatocyte growth factor receptor, the met receptor-tyrosine kinase. In vivo, loss of ptp1b or tcptp enhances hepatocyte growth factor-mediated phosphorylation of met. | SIGNOR-181331 |
P58012 | Q96EB6 | 0 | deacetylation | down-regulates | 0.501 | We find that foxl2 activity is repressed by the sirt1 deacetylase. | SIGNOR-182306 |
P45983 | Q05655 | 0 | phosphorylation | up-regulates | 0.501 | By contrast, after uv stimulation, rela directly induces the expression of pkcdelta, which in turn activates jnk. | SIGNOR-151428 |
P10912 | P18031 | 0 | dephosphorylation | down-regulates activity | 0.501 | PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates | SIGNOR-248420 |
P50148 | P21918 | 0 | binding | up-regulates activity | 0.501 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257369 |
Q9BQ15 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.501 | Ataxia telangiectasia mutated (ATM) kinase phosphorylates hSSB1 in response to DNA double-strand breaks (DSBs). This phosphorylation event is required for DNA damage-induced stabilization of hSSB1. | SIGNOR-262639 |
Q68EM7 | Q15642 | 0 | binding | down-regulates activity | 0.501 | Screening for potential mediators of this effect resulted in the identification of the Rac1-specific GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA and PKG substrates in platelets. We mapped the PKA/PKG phosphorylation sites to serine 702 on ARHGAP17 using Phos-tag gels... | SIGNOR-272158 |
P61764 | O96018 | 0 | binding | up-regulates activity | 0.501 | Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. | SIGNOR-264036 |
P10636-2 | P27361 | 0 | phosphorylation | down-regulates activity | 0.501 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275434 |
Q92530 | O95271 | 0 | ADP-ribosylation | down-regulates quantity by destabilization | 0.501 | We identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31. TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. | SIGNOR-263387 |
P48436 | Q13237 | 0 | phosphorylation | down-regulates activity | 0.501 | Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines|Prkg2 transfected glioma cell lines express a functional cGKII that can phosphorylate VASP and Sox9. | SIGNOR-278985 |
Q86UR5 | O15034 | 0 | binding | down-regulates activity | 0.501 | SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. | SIGNOR-264361 |
Q08050 | Q14680 | 0 | phosphorylation | up-regulates activity | 0.501 | MELK Activates FOXM1 Transcriptional Activity Leading to Upregulation of Mitotic Gene Expression.|The autoradiogram clearly shows in vitro phosphorylation of FOXM1 by MELK and CDK2 and cyclinA. | SIGNOR-278412 |
P19544 | Q96IZ0 | 0 | binding | down-regulates activity | 0.501 | We identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcriptional repressor. Functionally, par-4 inhibited transcription activated by WT1 | SIGNOR-240596 |
Q9UH73 | Q96K83 | 0 | binding | down-regulates | 0.501 | Ehzf inhibits the transcriptional activity of early b-cell factor (ebf), a transcription factor essential for specification of the b-cell lineage /ability to interact with the neural and hematopoietic transcription factor olf1/ebf1 and inhibit its binding to dna | SIGNOR-119300 |
P52333 | Q13261 | 0 | null | up-regulates | 0.501 | Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly ... | SIGNOR-256226 |
P63000 | Q9C0H5 | 0 | gtpase-activating protein | down-regulates activity | 0.501 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260494 |
P48736 | P05771 | 0 | phosphorylation | up-regulates activity | 0.501 | Remarkably we find that PKCβ phosphorylates Ser582 in the helical domain of the PI3Kγ catalytic subunit p110γ in response to clustering of the high-affinity IgE receptor (FcεRI) and/or store-operated Ca²⁺- influx in mast cells. Phosphorylation of p110γ correlates with the release of the p84 PI3Kγ adapter subunit from ... | SIGNOR-276496 |
P30307 | P62136 | 0 | binding | up-regulates | 0.501 | Pp1 recognizes cdc25 directly by interacting with a pp1-binding motif in the cdc25 n-terminus. | SIGNOR-118917 |
Q9H4E7 | P06239 | 0 | phosphorylation | up-regulates activity | 0.5 | In vitro kinase assays indeed demonstrated that Lck can phosphorylate wild-type IBP but not the Y210F mutant. IBP Binds PI(3,4,5)P3 upon Phosphorylation by Lck | SIGNOR-251372 |
Q15797 | O14595 | 0 | dephosphorylation | down-regulates | 0.5 | In human cells, rnai-mediated depletion of scp1 and scp2 increases the extent and duration of smad1 phosphorylation in response to bmp, the transcriptional action of smad1, and the strength of endogenous bmp gene responses. The present identification of the scp family as smad c-terminal phosphatases sheds light on the ... | SIGNOR-148434 |
P33032 | P42127 | 0 | binding | down-regulates activity | 0.5 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268713 |
P05412 | P01112 | 0 | phosphorylation | up-regulates activity | 0.5 | c-Jun was first shown to be phosphorylated in its transactivation domain (Ser-63 and Ser-73) by ERKs and p54-JNK. This is consistent with other studies which show that PD98059 inhibits up-regulation of c-Jun protein in Ras-transformed NIH-3T3 cells | SIGNOR-235522 |
P04049 | P17612 | 0 | phosphorylation | down-regulates activity | 0.5 | Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. Cyclic AMP (cAMP) blocks Raf-1 activation by stimulating its phosphorylation on serine 43 (Ser43), serine 233 (Ser233), and serine 259 (Ser259). | SIGNOR-250041 |
P15153 | P52306 | 0 | binding | up-regulates | 0.5 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171421 |
O95837 | Q9UBY5 | 0 | binding | up-regulates activity | 0.5 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257357 |
P22736 | P45983 | 0 | phosphorylation | down-regulates | 0.5 | We also identified the exact phosphorylation site of jnk to be serine 95 at the n terminus of tr3, around which a classical jnk phosphorylation motif exists. Furthermore, we demonstrated that tr3 phosphorylation by jnk coincided with its ubiquitination and degradation, resulting in the loss of its mitogenic activity. | SIGNOR-149998 |
Q07820 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.5 | MCL-1 was phosphorylated by GSK-3 at a conserved GSK-3 phosphorylation site (S159). S159 phosphorylation of MCL-1 was induced by IL-3 withdrawal or PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1. | SIGNOR-251242 |
P32245 | P42127 | 0 | binding | down-regulates activity | 0.5 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268708 |
P19438 | P28482 | 0 | phosphorylation | down-regulates activity | 0.5 | Phosphorylation of murine CD120a by p42(mapk/erk2) has been shown to inhibit its ability to initiate apoptosis while preserving signaling events such as NF-kappaB activation.|Additionally, we demonstrated that (i) the p42(mapk/erk2)-dependent phosphorylation of CD120a and DR3 occurred on Ser and Thr residues, (ii) p42(... | SIGNOR-249453 |
Q99558 | Q96JP5 | 0 | ubiquitination | up-regulates | 0.5 | Zfp91 interacts with and promotes the lys(63)-linked ubiquitination of nik and subsequent processing of p100 to p52. | SIGNOR-167331 |
Q9BSQ5 | O00506 | 0 | phosphorylation | up-regulates | 0.5 | CCM2 can be phosphorylated by STK25, and the kinase activity of STK25 is required for death signaling. | SIGNOR-263144 |
O15055 | P04150 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.5 | GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and re... | SIGNOR-268049 |
P49790 | Q92973 | 0 | relocalization | up-regulates activity | 0.499 | TNPO1 only mediates the nuclear import of a subset of proteins.|Among TNPO1 cargos, the most extensively characterized is the RNA binding protein heterogeneous nuclear ribonucleoprotein 1 (hnRNPA1) (27), which functions in several processes including mRNA biogenesis and promotion of transcription factor activity (28–30... | SIGNOR-262100 |
P50148 | Q969F8 | 0 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256750 |
Q4KMG0 | P55291 | 0 | binding | up-regulates activity | 0.499 | Cdo binds promyogenic cadherins form complexes with n- and m-cadherin. | SIGNOR-99250 |
P60953 | O15013 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.499 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260537 |
P06396 | Q9UKE5 | 0 | phosphorylation | up-regulates activity | 0.499 | In vitro , TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly ( xref ).|In vitro, TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly. | SIGNOR-280154 |
P04637 | P33981 | 0 | phosphorylation | up-regulates | 0.499 | Ttk/hmps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at thr18. phosphorylation at thr18 enhances p53-dependent activation of not only p21 but also lats2, two mediators of the postmitotic checkpoint. | SIGNOR-184931 |
P30679 | P30556 | 0 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257223 |
Q99466 | Q969H0 | 0 | ubiquitination | down-regulates | 0.499 | We show here that the f-box/wd40 repeat protein sel-10 negatively regulates notch receptor activity by targeting the intracellular domain of notch receptors for ubiquitin-mediated protein degradation. in conclusion, hsel-10 physically associates with mouse notch4(int-3) through the wd40 domain, whereas the f-box domai... | SIGNOR-110955 |
P52732 | Q9ULW0 | 0 | binding | down-regulates activity | 0.499 | Dimeric, but not monomeric, Eg5 was differentially inhibited by full-length and truncated TPX2, demonstrating that dimerization or residues in the neck region are important for the interaction of TPX2 with Eg5. | SIGNOR-265097 |
Q5UIP0 | Q13315 | 0 | binding | up-regulates activity | 0.499 | Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. After induction of double-strand breaks (DSBs), Rif1 formed foci that colocalized with other DNA-damage-response factors. This response was strictly dependent on ATM (ataxia telangiectasia mutated) ... | SIGNOR-259059 |
P04275 | P02679 | 0 | binding | down-regulates activity | 0.499 | Fibrinogen y-chain carboxyterminal (GQQHHLGGAKQAGDV) peptides inhibit fibrinogen, fibronectin (Fn), vitronectin, and von Willebrand factor (vWF) binding to the platelet glycoprotein Ilb-Illa complex (GP lIbII1a). | SIGNOR-251968 |
O00470 | P35453 | 0 | binding | up-regulates activity | 0.499 | We now show that the Hoxa-9 protein physically interacts with Meis1 proteins. Hox proteins from the other AbdB-like paralogs, Hoxa-10, Hoxa-11, Hoxd-12, and Hoxb-13, also form DNA binding complexes with Meis1b. DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with ... | SIGNOR-241235 |
Q96JE7 | Q92734 | 0 | binding | up-regulates | 0.499 | We identify tfg-1, a new conserved regulator of protein secretion that interacts directly with sec-16 and controls the export of cargoes from the endoplasmic reticulum in caenorhabditis elegans. Hydrodynamic studies indicate that tfg-1 forms hexamers that facilitate the co-assembly of sec-16 with copii subunits. | SIGNOR-173279 |
P40424 | P17481 | 0 | binding | up-regulates activity | 0.499 | the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. | SIGNOR-223153 |
P50148 | P25103 | 0 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257374 |
Q7Z460 | Q9ULW0 | 0 | binding | up-regulates activity | 0.499 | Phosphorylation of TPX2 regulated its interaction with CLASP1 but not Kif2a.|This suggests that TPX2 phosphorylation positively regulates the function of CLASP1.| This is in accord with a phosphoproteomics study that identified S121 and S125 as potential phosphorylation sites for Aurora A in mitotic HeLa cells | SIGNOR-265090 |
Q9UER7 | Q13315 | 0 | phosphorylation | down-regulates | 0.499 | The main phosphorylation site of daxx is identified to be ser564, which is a direct target of atm. Phosphorylation of endogenous daxx at ser564 occurs rapidly during the dna damage response and precedes p53 activation. Blockage of this phosphorylation event prevents the separation of daxx from mdm2, stabilizes mdm2, an... | SIGNOR-200889 |
O00459 | Q13191 | 0 | ubiquitination | down-regulates activity | 0.499 | Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. it can be postulated that Cbl-b, as an E3 Ub ligase, may play a general role in functional regulation of its target proteins through ubiquitination in a protein degradation-independent manner. | SIGNOR-271424 |
P16410 | P42681 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.498 | We demonstrate that rlk (resting lymphocyte kinase) is capable of phosphorylating ctla-4 at the yvkm motif. Consistent with this finding, rlk is capable of providing conditions for the binding of the sh2 domains of pi 3-kinase to the receptor. Ctla-4 is therefore the first known substrate for rlk suggesting the possibi... | SIGNOR-61624 |
Q13621 | Q9BYP7 | 0 | phosphorylation | up-regulates activity | 0.498 | We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activ... | SIGNOR-264626 |
P08754 | P48039 | 0 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256849 |
Q15796 | O15194 | 0 | dephosphorylation | down-regulates activity | 0.498 | Dephosphorylation of Smad2/3 Linkers by SCP2 and SCP3|MAPK-mediated linker phosphorylation appears to have a dual role in Smad2/3 regulation. Mitogens and hyperactive Ras result in extracellular signal-regulated kinase (ERK)-mediated phosphorylation of Smad3 at Ser-204, Ser-208, and Thr-179 and of Smad2 at Ser-245/250/... | SIGNOR-248310 |
Q15797 | O15194 | 0 | dephosphorylation | down-regulates activity | 0.498 | Smad proteins transduce bone morphogenetic protein (BMP) and transforming growth factor-beta (TGFbeta) signals upon phosphorylation of their C-terminal SXS motif by receptor kinases.|Phosphatases that dephosphorylate the linker region are therefore likely to play an integral part in the regulation of Smad activity. We ... | SIGNOR-248314 |
P63092 | P21728 | 0 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256796 |
O60271 | Q4KMG0 | 0 | binding | up-regulates activity | 0.498 | In this study, we report that the cdo intracellular region interacts with jlp, a scaffold protein for the p38alpha/beta mapk pathway. | SIGNOR-150282 |
Q15797 | Q9GZU7 | 0 | dephosphorylation | down-regulates | 0.498 | In human cells, rnai-mediated depletion of scp1 and scp2 increases the extent and duration of smad1 phosphorylation in response to bmp, the transcriptional action of smad1, and the strength of endogenous bmp gene responses. The present identification of the scp family as smad c-terminal phosphatases sheds light on the ... | SIGNOR-148396 |
P31751 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.498 | The activation of PKBbeta and PKBgamma by PDK1 was accompanied by the phosphorylation of the residues equivalent to Thr308 in PKBalpha, namely Thr309 (PKBbeta) and Thr305 (PKBgamma). PKBgamma which had been activated by PDK1 possessed a substrate specificity identical with that of PKBalpha and PKBbeta towards a range o... | SIGNOR-248997 |
Q01484 | Q5VST9 | 0 | relocalization | up-regulates quantity | 0.498 | Ankyrin-B is targeted to the M-line via its interaction with the C-terminal domain of the large sarcomeric protein obscurin. Obscurin is targeted to the M-line via its N-terminal interactions with myomesin and titin. This population of ankyrin-B recruits B56α, a regulatory subunit of protein phosphatase 2A, to the M-li... | SIGNOR-266726 |
P04637 | Q9NRC8 | 0 | deacetylation | down-regulates | 0.498 | We found that sirt7 interacts with p53 and efficiently deacetylates p53 in vitro, which corresponds to hyperacetylation of p53 in vivo. | SIGNOR-160539 |
Q96HZ4 | P68400 | 0 | phosphorylation | up-regulates activity | 0.498 | Hes6 inhibits the interaction of Hes1 with its transcriptional corepressor Gro/TLE. Moreover, it promotes proteolytic degradation of Hes1. This effect is maximal when both Hes1 and Hes6 contain the WRPW motif and is reduced when Hes6 is mutated to eliminate a conserved site (Ser183) that can be phosphorylated by protei... | SIGNOR-250890 |
P03372 | P42345 | 0 | phosphorylation | up-regulates activity | 0.498 | Thus our results indicate that the interaction between ER\u03b1 and raptor is necessary to recruit raptor to the nucleus, where mTOR phosphorylates and activates ER\u03b1. | SIGNOR-278295 |
Q13936 | P17612 | 0 | phosphorylation | up-regulates activity | 0.498 | These findings reveal an essential role for _1C phosphorylation at Ser1928 in stimulating CaV1.2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes | SIGNOR-251709 |
P61254 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.498 | In addition, Mdm2 ubiquitylates L26, leading to its proteasome-mediated degradation.|We now report that Mdm2 regulates p53 levels also by targeting ribosomal protein L26. | SIGNOR-278828 |
Q96QT4 | Q9BX84 | 0 | phosphorylation | down-regulates quantity | 0.498 | We found TRPM6 and TRPM7 both autophosphorylate threonine residues, but only TRPM6 crossphosphorylates TRPM7, and not the reverse . | SIGNOR-279770 |
P01106 | Q01850 | 0 | binding | up-regulates activity | 0.498 | Here we find that cdr2 is cell cycle regulated in tumor cells with protein levels peaking in mitosis. As cells exit mitosis, cdr2 is ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) and rapidly degraded by the proteasome. Previously we showed that cdr2 binds to the oncogene c-myc, and here we extend th... | SIGNOR-252000 |
O00418 | P54646 | 0 | phosphorylation | up-regulates activity | 0.498 | Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398. phosphorylation of eEF2 kinase at Ser-398 leads to an increase in its activity. | SIGNOR-250158 |
Q01718 | P42127 | 0 | binding | down-regulates activity | 0.498 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanoc... | SIGNOR-268695 |
P63000 | O14827 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.498 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260574 |
Q13905 | P08631 | 0 | phosphorylation | up-regulates | 0.498 | We also showed that ctla-4 receptor signaling mediates tyrosine phosphorylation in the c3g protein, and that this is required for augmented activation of rap1 and increased adhesion mediated by leukocyte function-associated antigen type 1 (lfa-1). ctla-4 signaling leads to phosphorylation of c3g tyrosine 504. the src... | SIGNOR-203613 |
P16520 | P43115 | 0 | binding | up-regulates | 0.498 | Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i) | SIGNOR-88192 |
P42575 | Q13490 | 0 | binding | down-regulates | 0.498 | However, among hiap1, hiap2 and xiap, only hiap2 binds and inhibits caspase-2. | SIGNOR-146738 |
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