IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P13807 | P49840 | 0 | phosphorylation | down-regulates | 0.411 | Glycogen synthase kinase-3 (gsk-3) phosphorylates four serine residues in the cooh terminus of glycogen synthase. Phosphorylation of one of these residues, ser640 (site 3a), causes strong inactivation of glycogen synthase | SIGNOR-118927 |
P15311 | Q5S007 | 0 | phosphorylation | up-regulates activity | 0.411 | LRRK2 also phosphorylated ezrin and radixin, which are related to moesin, at the residue equivalent to Thr558, as well as a peptide (LRRKtide: RLGRDKYKTLRQIRQ) encompassing Thr558. | SIGNOR-279202 |
P33981 | P24941 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.411 | Cdk2 phosphorylates Mps1 at T468, attenuating the function of a degradation signal found in amino acids 420\u2013507 (encoded by exons 12 and 13) and allowing the accumulation of a centrosomal pool of Mps1 that represents no more than 10% of total cellular Mps1 ( xref ). | SIGNOR-279398 |
P11021 | Q15011 | 0 | relocalization | up-regulates quantity by stabilization | 0.411 | A key inhibitor of the turnover and Nt-arginylation of BiP was HERP (homocysteine-responsive ER protein), a 43-kDa ER membrane-integrated protein that is an essential component of ER-associated protein degradation. | SIGNOR-261346 |
P07900 | Q9P278 | 0 | binding | down-regulates activity | 0.411 | FNIP1 and FNIP2 facilitate FLCN binding to Hsp90 chaperone. Our results suggest that FNIP1 is a potent inhibitor of Hsp90 ATPase activity, as 200 nM of FNIP1 inhibits Hsp90 ATPase activity by 50-fold. FNIP2 also has shown inhibitory activity towards Hsp90; however, it required 1.6 μM of FNIP2 to inhibit the ATPase act... | SIGNOR-261414 |
Q92823 | P54762 | 0 | phosphorylation | up-regulates activity | 0.411 | EphB receptors were found to induce phosphorylation of NrCAM on the tyrosine residue within the FIGQY ankyrin binding motif, inhibiting ankyrin recruitment. Furthermore, NrCAM phospho-FIGQY levels in the SC were decreased in EphB1/3 and EphB1/2/3 null mice and increased in mutant mice overexpressing constitutively acti... | SIGNOR-262862 |
Q02880 | Q13315 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.411 | Specifically, DNA damage signal, triggered by teniposide (VM-26) treatment, activates ATM, cooperating with CK1 to phosphorylate TOP2β on Ser1134 and Ser1130, respectively, in a canonical degron motif to facilitate β-TrCP binding and subsequent degradation.ATM binds with and phosphorylates TOP2β at Ser1134 to promote i... | SIGNOR-277510 |
P54253 | P31749 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.411 | Interaction of Ataxin-1 and 14-3-3 Requires Akt Phosphorylation at S776. 14-3-3 protein, a multifunctional regulatory molecule, mediates the neurotoxicity of ataxin-1 by binding to and stabilizing ataxin-1, thereby slowing its normal degradation. | SIGNOR-252561 |
Q16621 | P45983 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.411 | Through use of different approaches including nano-scale proteomics, we show that activated-JNK, or Phospho-JNK (P-JNK), physically interacts with p45/NF-E2 and phosphorylates its Ser157 residue. This reaction leads to the poly-ubiquitination of p45/NF-E2 at one or more of six Lys residues, one of which being also a su... | SIGNOR-275552 |
Q02577 | Q8TAP4 | 0 | binding | up-regulates activity | 0.411 | Here we found that LMO3 forms a complex with HEN2 and acts as an upstream mediator for transcription of Mash1 in neuroblastoma. | SIGNOR-254827 |
O14757 | P06493 | 0 | phosphorylation | up-regulates | 0.411 | Chk1 itself is also subject to cdk-mediated phosphorylation at serines 286 and 301 (s286 and 301). We show that chk1 s301 phosphorylation increases as cells progress through s and g2 and that both cdk1 and cdk2 are likely to contribute to this modification in vivo. We also find that substitution of s286 and s301 with n... | SIGNOR-175071 |
P63096 | Q13304 | 0 | binding | up-regulates activity | 0.411 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256692 |
Q13571 | Q96J02 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.411 | Here, we found that the level of LAPTM5 protein is regulated negatively by the degradation through ubiquitination by ITCH, an E3 ubiquitin ligase. ITCH directly binds to the PPxY motif of LAPTM5 via its WW domains and promotes ubiquitination through a HECT-type ligase domain. | SIGNOR-272721 |
P30307 | P45983 | 0 | phosphorylation | down-regulates | 0.411 | Here we show that jnk directly phosphorylates cdc25c at serine 168 during g(2) phase of the cell cycle. Cdc25c phosphorylation by jnk negatively regulates its phosphatase activity and thereby cdk1 activation, enabling a timely control of mitosis onset. | SIGNOR-164089 |
Q9H2B2 | P45983 | 0 | phosphorylation | up-regulates activity | 0.411 | JNK phosphorylates Syt 4 at Ser135 in vitro and in vivo. | SIGNOR-273673 |
P06239 | P06241 | 0 | phosphorylation | down-regulates activity | 0.411 | In nonactivated T cells, CCR7 triggering induced a Fyn dependent phosphorylation of the inhibitory Tyr505 of Lck.|Inhibiting Fyn in these nonactivated T cells prevented the negative regulation of Lck and facilitated high CCR7 driven T cell chemotaxis. | SIGNOR-279986 |
Q08211 | Q9BRS8 | 0 | binding | up-regulates activity | 0.41 | La ribonucleoprotein domain family member 6 (LARP6) is the protein that binds 5' SL with high affinity and specificity and coordinates their translation. Here we show that RNA helicase A (RHA) is tethered to the 5' SL of collagen mRNAs by interaction with the C-terminal domain of LARP6. | SIGNOR-273500 |
P10275 | Q6ZRS2 | 0 | binding | up-regulates activity | 0.41 | The SNF2-related CBP activator protein (SRCAP) serves as a coactivator for several nuclear receptors including the androgen receptor (AR). SRCAP is an ATPase that is the core subunit of a large multiprotein complex and was shown to incorporate the histone variant H2A.Z into nucleosomes. In this report, we demonstrate t... | SIGNOR-255221 |
Q15109 | P58753 | 0 | binding | up-regulates activity | 0.41 | These results indicate that TIRAP functions as an essential adaptor protein for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it. | SIGNOR-280459 |
P60953 | Q5TG30 | 0 | gtpase-activating protein | down-regulates activity | 0.41 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260497 |
O60674 | P00519 | 0 | phosphorylation | up-regulates activity | 0.41 | Jak2 peptide substrate studies indicated that the Bcr-Abl and Abl tyrosine kinases specifically phosphorylated Y1007 of Jak2 but only poorly phosphorylated Y1008. Phosphorylation of Y1007 of Jak2 is known to be critical for its tyrosine kinase activation. | SIGNOR-245365 |
O43255 | Q92630 | 0 | phosphorylation | up-regulates | 0.41 | In the present study, we identify the serine/threonine kinase dyrk2 as siah2 interaction partner that phosphorylates siah2 at five residues (ser16, thr26, ser28, ser68, and thr119). accordingly, phosphorylated siah2 is more active than the wild-type e3 ligase and shows an increased ability to trigger the hif-1?-Mediat... | SIGNOR-198729 |
P63000 | Q15669 | 0 | relocalization | down-regulates activity | 0.41 | Therefore, RhoH functions as a Rac1 antagonist by inhibiting Rac1 translocation to the cell plasma membrane in the regulation of cell migration and F-actin assembly of HPCs | SIGNOR-259085 |
Q9P1W9 | P42229 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.41 | The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting bec... | SIGNOR-249622 |
P36956 | P17676 | 0 | transcriptional regulation | up-regulates quantity | 0.41 | These results show that GSK3β is involved in regulating phosphorylation and activation of C/EBPβ and that this transcription factor is required to transactivate srebf1a expression, leading to the early steps of adipogenesis | SIGNOR-251645 |
Q9UHD2 | P35813 | 0 | dephosphorylation | down-regulates activity | 0.41 | Furthermore, PPM1A, but not PPM1B, serves as an efficient phosphatase to dephosphorylate Ser 172 residue of both TBK1 and IKKepsilon kinases, which is critical for their kinase activities.|In a similar in vitro phosphatase assay, incubation of PPM1A also eliminated TBK1 and IKKepsilon phosphorylation at Ser 172 residue... | SIGNOR-276966 |
Q14191 | P00519 | 0 | phosphorylation | up-regulates | 0.41 | We thus hypothesized that wrn may interact with the abl tyrosine kinase in the dna damage response. Here, we provide evidence for a functional and physical interaction between wrn and c-abl, including wrn relocalization in response to dna damage, suggesting that this protein-protein interaction participates in a shared... | SIGNOR-86497 |
P24385 | Q9Y463 | 0 | phosphorylation | down-regulates | 0.41 | Further, we found that not only gsk-3beta but also dyrk1b modulates cyclin d1 subcellular localization by the phosphorylation of thr(288). These results suggest that dif-3 induces degradation of cyclin d1 through the gsk-3beta- and dyrk1b-mediated threonine phosphorylation in hela cells | SIGNOR-150126 |
P04150 | O15516 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.41 | We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the 'lysine clust... | SIGNOR-253699 |
Q9P0L2 | Q15831 | 0 | phosphorylation | up-regulates | 0.41 | Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1we recently demonstrated that the lkb1 tumour suppressor kinase, in complex with the pseudokinase strad and the scaffolding protein mo25, phosphorylates and activates amp-activated protein kinase (ampk). A total of 12 human kin... | SIGNOR-122545 |
P15172 | P40424 | 0 | binding | up-regulates activity | 0.41 | These domains are necessary for the stable binding of myod to the myogenin promoter through an interaction with an adjacent protein complex containing the homeodomain protein pbx, which appears to be constitutively bound at this site | SIGNOR-124834 |
Q92879 | P31749 | 0 | phosphorylation | up-regulates activity | 0.41 | In normal myoblasts, Akt kinase phosphorylates CUGBP1 at Ser28 and increases interactions of CUGBP1 with cyclin D1 mRNA. | SIGNOR-280173 |
P06733 | P12931 | 0 | phosphorylation | up-regulates | 0.41 | The present finding suggested that the tyrosine residue at position 44 in chicken alpha-enolase is the phosphorylation site by the tyrosine kinase. Our data suggest that eno1 was upregulated by caga protein through activating the src and mek/erk signal pathways | SIGNOR-205092 |
Q05469 | Q13131 | 0 | phosphorylation | down-regulates | 0.41 | Phosphorylation of bovine hormone-sensitive lipase by the amp-activated protein kinase. | SIGNOR-58255 |
O75030 | Q15418 | 0 | phosphorylation | down-regulates | 0.41 | The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73, whereas serine 409 serves as a ... | SIGNOR-174760 |
Q15013 | P53350 | 0 | phosphorylation | down-regulates activity | 0.41 | Purified Plk1 bound to p31comet and phosphorylated it, resulting in the suppression of its activity (with TRIP13) to disassemble checkpoint complexes. We conclude that Plk1 phosphorylates p31 on S102 and on five additional sites. The phosphorylation of the additional sites was possibly not detectable in HeLa cell extra... | SIGNOR-265970 |
Q96Q89 | P06493 | 0 | phosphorylation | up-regulates activity | 0.41 | Here we report the identification of a novel KRP, termed KRMP1, which undergoes in vivo phosphorylation. The carboxyl-terminal globular tail domain is strongly phosphorylated by mitotic kinase activities almost attributed to cdc2 kinase, which is responsible for phosphorylation on residue Thr-1604 of KRMP1. | SIGNOR-262695 |
Q13418 | Q13153 | 0 | phosphorylation | up-regulates | 0.41 | We found that pak1 phosphorylates ilk at threonine-173 and serine-246 in vitro and in vivo. together, these results suggest that ilk is a pak1 substrate, undergoes phosphorylation-dependent shuttling between the cell nucleus and cytoplasm, and interacts with gene-regulatory chromatin. | SIGNOR-154303 |
Q12955 | Q6ZMI3 | 0 | relocalization | up-regulates quantity | 0.41 | Ankyrin-G is recruited to the nodes of Ranvier by gliomedin, which is produced by Schwann cells and accumulates in the perinodal extracellular matrix. As a ligand for neurofascin-186, gliomedin causes the nodal clustering of this cell adhesion molecule, which in turn recruits to the nodal plasma membrane an ankyrin-G p... | SIGNOR-266725 |
Q92519 | Q9HCE7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.41 | In this study, we found that TRIB2 was up-regulated and exhibited high stability in liver cancer cells compared with other cells. We performed a structure-function analysis of TRIB2 and identified a domain (amino acids 1-5) at the N terminus that interacted with the E3 ubiquitin ligase Smurf1 and was critical for prot... | SIGNOR-275432 |
Q969H0 | P31749 | 0 | phosphorylation | up-regulates activity | 0.41 | A reciprocal immunoprecipiation with anti-phospho-Akt substrate antibody followed by immunoblotting with anti-FLAG antibodies confirmed these findings (Fig. 1C). We concluded that Fbw7 is phosphorylated at S227 in vivo. Phosphorylation of Fbw7 is required for its biological activity. | SIGNOR-276328 |
O15350 | Q9H4B4 | 0 | phosphorylation | down-regulates activity | 0.41 | In this study, we found that Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.|Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. | SIGNOR-279647 |
Q14524 | Q92913 | 0 | binding | down-regulates activity | 0.41 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253415 |
P02452 | Q8NBJ5 | 0 | glycosylation | up-regulates activity | 0.41 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261152 |
Q03060 | P27361 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.41 | The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer than its wild-type counterpart. This alteration in stabili... | SIGNOR-275978 |
Q6R327 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.409 | We show that this process is dependent on glycogen synthase kinase 3 (GSK3): GSK3 was associated with rictor and directly phosphorylated the Thr-1695 site in a putative CDC4 phospho-degron motif of rictor; mutation of this site impaired the interaction between rictor and FBXW7, decreased rictor ubiquitination, and incr... | SIGNOR-276898 |
O00592 | P19544 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.409 | Binding of WT1 to conserved elements within the Podocalyxin gene promoter results in potent transcriptional activation, and the specific expression pattern of Podocalyxin in the developing kidney mirrors that of WT1 itself. | SIGNOR-252300 |
Q86UR1 | Q5TCZ1 | 0 | binding | up-regulates activity | 0.409 | Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation | SIGNOR-264708 |
Q02078 | Q13469 | 0 | binding | up-regulates | 0.409 | Upon dephosphorylation by calcineurin, nfatc2, also referred to as nfatp/nfat1, translocates to the nucleus where it directly associates with mef2a and -d. Nfatc2 stimulates mef2-dependent transcription by facilitating recruitment of the p300 coactivator to mef2-response elements. | SIGNOR-117586 |
Q13285 | P10275 | 0 | binding | up-regulates | 0.409 | Ar suppresses transcription of the lhbeta subunit by interacting with steroidogenic factor-1. | SIGNOR-109996 |
P20340 | O43896 | 0 | relocalization | up-regulates quantity | 0.409 | Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, regulates the pericentr... | SIGNOR-266877 |
P04637 | Q13464 | 0 | phosphorylation | up-regulates quantity | 0.409 | Besides, ROCK1 phosphorylated p53 at ser15 to up-regulate its protein level. | SIGNOR-280108 |
P48735 | Q9NXA8 | 0 | catalytic activity | up-regulates activity | 0.409 | Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate dehydrogenase (G6PD), respectively, and thus activates both NADPH-producing enzymes. | SIGNOR-261212 |
P50222 | P15863 | 0 | binding | up-regulates activity | 0.409 | We show that Mox1 and Mox2 proteins are capable of interacting with Pax1 and Pax3. We propose that the Mox family of homeodomain proteins participates in the molecular signaling network regulating the diverse events of somite development through the physical interaction with the Pax1 and Pax3 members of the Pax family. | SIGNOR-222232 |
P35222 | P36888 | 0 | phosphorylation | up-regulates activity | 0.409 | Endogenous beta-catenin co-immunoprecipitated with endogenous activated FLT3, and recombinant activated FLT3 directly phosphorylated recombinant beta-catenin. Finally, FLT3 inhibitor decreased tyrosine phosphorylation of beta-catenin in leukemia cells obtained from FLT3-ITD-positive AML patients. These data demonstrate... | SIGNOR-260124 |
O43609 | Q06124 | 0 | dephosphorylation | down-regulates | 0.409 | These results identify sprouty proteins as in vivo targets of corkscrew/shp-2 tyrosine phosphatases and show how corkscrew/shp-2 proteins can promote rtk signaling by inactivating a feedback inhibitor. | SIGNOR-144547 |
P19174 | P63211 | 0 | binding | up-regulates | 0.409 | Furthermore, this work suggested that the gbetagamma subunits released upon gi activation activated phospholipase c-gamma (plc-gamma) to produce inositol 3 phosphate (ip3) which would subsequently increase intracellular ca2+ abundance. | SIGNOR-199144 |
Q9H2G9 | Q9NTX7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.409 | Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated pro... | SIGNOR-263340 |
Q7L591 | P07948 | 0 | phosphorylation | up-regulates activity | 0.409 | An adaptor protein Dok-3 mediates the suppressive function of LYN. The Dok-3 phosphorylated by LYN upon BCR stimulation forms a complex with GRB2, which allows it to enter into the signalosome and associate with activation of SHIP protein. This translocation facilitates the efficient inhibition of PLCc2 and SYK from ac... | SIGNOR-268447 |
Q9NS23 | P11802 | 0 | phosphorylation | down-regulates | 0.409 | This skp2-dependent destruction of rassf1a requires phosphorylation of the latter on serine-203 by cyclin d-cyclin-dependent kinase 4. | SIGNOR-159849 |
Q01484 | O00533 | 0 | relocalization | up-regulates quantity | 0.409 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266722 |
P00533 | P42685 | 0 | phosphorylation | down-regulates activity | 0.409 | Furthermore, Rak/Frk inhibited mutant EGFR phosphorylation at an activating site and dramatically decreased the levels of EGFR\u0394747-749/A750P from the plasma membrane.|Taken together, the results suggest that Rak and Frk inhibits EGFR signaling in cancer cells and has elevated activity against EGFR exon 19 mutants. | SIGNOR-279177 |
Q12888 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.409 | Here we report for the first time that tumor suppressor p53-binding protein 1 (53BP1) is phosphorylated at serine 1342 (S1342) by Aurora kinase B both in vitro and in human cells, which is required for optimal recruitment of 53BP1 at kinetochores. | SIGNOR-264411 |
Q14457 | P19484 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.409 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276558 |
P60709 | Q9Y4I1 | 0 | binding | up-regulates activity | 0.409 | Myosin Va regulates exocytosis of large dense-core vesicles (LDCVs). interestingly, inhibition of myosin Va potentiates LDCV exocytosis to the same extent as F-actin depolymerization does, suggesting that myosin Va cooperates with the actin cytoskeleton to impede or control LDCV exocytosis | SIGNOR-269280 |
Q9Y365 | P68400 | 0 | phosphorylation | down-regulates | 0.409 | Interestingly, hypotonic extracts prepared from hek293t cells expressing the serine to alanine mutant exhibited increased lipid transfer activity compared with those from wild-type stard10-expressing cells, suggesting that, in a cellular context, phosphorylation on serine 284 negatively regulates stard10 activity | SIGNOR-155740 |
P26678 | Q13976 | 0 | phosphorylation | up-regulates activity | 0.409 | Phosphorylation of PLB by PKA or cGKI at Ser 16 relieves the inhibition of SERCA2a and results in increased contractility through enhanced Ca 2+ i reuptake into the SR. | SIGNOR-279269 |
Q68CZ2 | P12931 | 0 | phosphorylation | up-regulates | 0.408 | Tyrosines in the sh2 domain contribute to the biological activity of tensin-3, and phosphorylation of these tyrosines can regulate ligand binding. tensin-3 is a src substrate | SIGNOR-187843 |
Q9P2Y5 | P42345 | 0 | phosphorylation | up-regulates activity | 0.408 | MTOR phosphorylates UVRAG at serine 550 and serine 571 | SIGNOR-276919 |
Q13469 | P48454 | 0 | dephosphorylation | up-regulates activity | 0.408 | NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote tr... | SIGNOR-248512 |
Q13507 | Q13976 | 0 | phosphorylation | down-regulates | 0.408 | The present study demonstrates that human trpc3 expressed in hek293 cells forms store-operated ca2+ influx channels, the activity of which is inhibited by pkg. The inhibition is due to a direct phosphorylation of pkg on trpc3 channels at position t11 and s263. | SIGNOR-142961 |
Q13507-3 | Q13976 | 0 | phosphorylation | down-regulates | 0.408 | The present study demonstrates that human trpc3 expressed in hek293 cells forms store-operated ca2+ influx channels, the activity of which is inhibited by pkg. The inhibition is due to a direct phosphorylation of pkg on trpc3 channels at position t11 and s263. | SIGNOR-142957 |
Q86UR1 | P12931 | 0 | phosphorylation | up-regulates | 0.408 | Here, we show that the interaction of noxa1 and tks proteins is dependent on src activity. Interestingly, the abolishment of src-mediated phosphorylation of tyr110 on noxa1 and of tyr508 on tks4 blocks their binding and decreases nox1-dependent ros generation. | SIGNOR-168545 |
P07101 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.408 | In addition, we demonstrate that co-expression of cdk5 and its regulatory activator p35 with TH increases the stability of TH.|We show that cdk5 phosphorylates TH at serine 31 and that this phosphorylation is associated with an increase in total TH activity. | SIGNOR-279022 |
Q13541 | Q9H0H3 | 0 | binding | down-regulates quantity by destabilization | 0.408 | We identified the KLHL25-CUL3 complex as the E3 ubiquitin ligase, which targets hypophosphorylated 4E-BP1. Thus, the activity of eIF4E is under homeostatic control via the regulation of the levels of its repressor protein 4E-BP1 through ubiquitination. | SIGNOR-272049 |
Q14344 | Q96RI0 | 0 | binding | up-regulates | 0.408 | Upon proteolysis, the newly formed n terminus acts as a tethered ligand that activates the receptor and initiates signaling cascades through multiple g proteins (galfaq, galfai, and galfa12/13) | SIGNOR-196015 |
P17275 | Q96J02 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.408 | Itch promotes Ub conjugation to JunB Molecularly, Itch associated with and induced ubiquitination of JunB, a transcription factor that is involved in TH2 differentiation. However, in Itch−/− T cells under the same conditions, degradation of JunB was markedly delayed. | SIGNOR-272619 |
Q01130 | Q13627 | 0 | phosphorylation | down-regulates activity | 0.408 | Dyrk1A inhibits SC35\u2032s activity to promote tau exon 10 inclusion.|Dyrk1A interacts with and phosphorylates SC35 and inhibits its activity to promote tau exon 10 inclusion. | SIGNOR-278307 |
Q01453 | P16144 | 0 | binding | up-regulates activity | 0.408 | PMP22 is in a complex with α6β4 integrin and laminin. PMP22 and β4 integrin are in a complex in a variety of cell types. The interaction with the integrins provides PMP22 with the ability to modulate the cell–ECM communications, as well as intracellular events. Signaling between the ECM and the intracellular compartmen... | SIGNOR-251896 |
P50148 | Q9NPG1 | 0 | binding | up-regulates | 0.408 | Gpcrs signal through four relatively small families of galfa proteins (galfas, galfai/o, galfaq, and galfa12/13), and if fzd receptors are classic gpcrs, they should signal through one of these four galfa families. | SIGNOR-122895 |
Q14524 | Q13554 | 0 | phosphorylation | up-regulates activity | 0.408 | Among the sites identified, only six were previously suggested to be the targets for specific kinases using in silico and/or in vitro analyses: S36 and S525 were attributed to the regulation by PKA; S484 and S664 were assigned to the serum- and glucocorticoid-inducible kinase 3 (SGK3); and S516 and S571 were ascribed t... | SIGNOR-275773 |
Q9H492 | Q8IXH6 | 0 | binding | up-regulates | 0.408 | Tp53inp2 is a scaffold protein that recruits lc3 and/or lc3-related proteins to the autophagosome membrane by interacting with the transmembrane protein vmp1 | SIGNOR-182614 |
Q9BV73 | Q96CN5 | 0 | binding | up-regulates activity | 0.408 | Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. LRRC45 interacts with C-Nap1 and rootletin | SIGNOR-273703 |
P30291 | P68400 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.408 | In the present study, we show that phosphorylation of S123 (pS123) by CDK promoted the binding of Wee1A to beta-TrCP through three independent mechanisms. S123 phosphorylation creates a PBD-binding motif and accelerates S53 phosphorylation by Plk1. | SIGNOR-276038 |
P00441 | Q16236 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.408 | BTG2 was found to up-regulate expression of antioxidant enzymes known to be regulated by NFE2L2, including catalase, SOD1, and SOD2 | SIGNOR-254653 |
Q8TDD2 | Q16539 | 0 | phosphorylation | up-regulates activity | 0.408 | We therefore propose that Osterix binds to Sp1 sequences on target gene promoters and that its phosphorylation by p38 enhances recruitment of coactivators to form transcriptionally active complexes | SIGNOR-255791 |
O14490 | Q00535 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.408 | Taken together, these sets of data suggest that Abeta triggers the phosphorylation of GKAP by cdk5 at the serine residues S77 and S111 that in turn are crucial for GKAP degradation. | SIGNOR-279153 |
P20226 | Q12947 | 0 | binding | up-regulates activity | 0.408 | The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. | SIGNOR-220373 |
Q92911 | Q06710 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.408 | Pax8 has an essential role in thyroid organogenesis and differentiation, being the main mediator of thyroid gene transcription, including the NIS gene. | SIGNOR-251990 |
Q16539 | P35813 | 0 | dephosphorylation | down-regulates activity | 0.408 | Moreover, when expressed in mammalian cells, pp2ca inhibited the activation of the p38 and jnk cascades induced by environmental stresses. Both in vivo and in vitro observations indicated that pp2ca dephosphorylated and inactivated mapkks (mkk6 and sek1) and a mapk (p38) in the stress-responsive mapk cascades. Furtherm... | SIGNOR-59618 |
P30679 | P41231 | 0 | binding | up-regulates activity | 0.408 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257031 |
P36888 | P43405 | 0 | phosphorylation | up-regulates activity | 0.407 | Only two mutants, FLT3-KD (V5) Y768A and Y955A, were resistant to SYK-mediated FLT3 phosphorylation, suggesting that SYK directly phosphorylates FLT3 at sites Y768 and Y955 ( ).|SYK Enhances FLT3 WT and Mutant Activation by Phosphorylation of Residues Y768 and Y955. | SIGNOR-278431 |
P15927 | Q9NUX5 | 0 | binding | down-regulates activity | 0.407 | The current model for how telomeres repress ATR signaling proposes that POT1/TPP1 prevents the binding of RPA to the single-stranded telomeric DNA | SIGNOR-263324 |
Q15717 | P06493 | 0 | phosphorylation | down-regulates activity | 0.407 | Cdk1 inhibition promoted a cytoplasmic accumulation of HuR, while a predominately nuclear localization of HuR was observed under conditions of high Cdk1 activity.|Kim et al. further showed that Cdk1-dependent Ser-202 phosphorylation of HuR was essential for 14-3-3\u03b8 binding to HuR. | SIGNOR-279014 |
P29597 | P08575 | 0 | dephosphorylation | down-regulates activity | 0.407 | CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling|these results show that CD45 dephosphorylates functionally important tyrosine residues. It should be noted that, as with our phosphatase assays in vitro, Tyr 1022 and Tyr 1023 of JAK1, Tyr 1007 and Tyr 1008 of JAK2, and Tyr 1054 and Tyr 105... | SIGNOR-248357 |
Q92558 | P12931 | 0 | phosphorylation | up-regulates | 0.407 | The wave/scar proteins regulate actin polymerisation at the leading edge of motile cells via activation of the arp2/3 complex in response to extracellular cues.Src-dependent phosphorylation of scar1 promotes its association with the arp2/3 complex | SIGNOR-142724 |
O95837 | Q9UNW8 | 0 | binding | up-regulates activity | 0.407 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257396 |
P63092 | Q13255 | 0 | binding | up-regulates activity | 0.407 | MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G p... | SIGNOR-264077 |
P42680 | Q08881 | 0 | phosphorylation | up-regulates | 0.407 | Tec family protein tyrosine kinases (tfks) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the sh3 domain via a transphosphorylation mechanism. Here, we could confirm that ... | SIGNOR-98090 |
P52732 | Q8TDX7 | 0 | phosphorylation | up-regulates activity | 0.407 | NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites. | SIGNOR-273890 |
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