IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P04040 | P00519 | 0 | phosphorylation | up-regulates activity | 0.403 | C-abl and arg phosphorylated catalase at tyr231 and tyr386 in vitrocatalase is a major effector in the defense of aerobic cells against oxidative stress. Recent studies have shown that catalase activity is stimulated by the c-abl and arg tyrosine kinases | SIGNOR-101302 |
P15407 | P15408 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.403 | Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. | SIGNOR-261602 |
P08754 | Q15391 | 0 | binding | up-regulates activity | 0.403 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256866 |
Q9UNS2 | P58340 | 0 | binding | up-regulates | 0.403 | As downstream elements of mlf1 leading to cell growth arrest due to p53 accumulation, we identified two factors, csn3, the third component of the cop9 signalosome (csn), and cop1, a recently characterized e3 ubiquitin ligase for p53 | SIGNOR-135937 |
P04626 | Q96JA1 | 0 | ubiquitination | down-regulates | 0.403 | We report upregulation of lrig1 transcript and protein upon egf stimulation, and physical association of the encoded protein with the four egfr orthologs of mammals. Upregulation of lrig1 is followed by enhanced ubiquitylation and degradation of egfr. The underlying mechanism involves recruitment of c-cbl, an e3 ubiqui... | SIGNOR-139948 |
P50539 | Q9UQE7 | 0 | binding | down-regulates activity | 0.403 | We identified a novel ZIP-containing protein, Mmip1 (Mad member interacting protein 1) that strongly dimerizes with all four Mad members, but not with c-myc. Mmip1 can inhibit DNA binding by Max-Mad heterodimers and, in vivo, can reverse the suppressive eects of Mad proteins on c-myc functions. | SIGNOR-241223 |
Q4G163 | Q9UQM7 | 0 | phosphorylation | up-regulates activity | 0.403 | CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. | these results implicate the 192RSST motif of Emi2 as a critical molecular target of CaMKII during CSF release | SIGNOR-260907 |
O14920 | Q9UHD2 | 0 | binding | up-regulates | 0.403 | A physical and functional map of the human tnf-alpha/nf-kappa b signal transduction pathway. | SIGNOR-121576 |
Q86UL8 | Q8NFZ4 | 0 | binding | up-regulates activity | 0.403 | S-SCAM is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ-domain-containing proteins that include the synaptic organising molecule PSD-95. The PDZ domain of S-SCAM binds to the C-terminal tail of NL2, forming a ternary complex at the cell membrane (Figure 2b). The DGC is potentially recruite... | SIGNOR-265444 |
P00533 | Q13671 | 0 | binding | up-regulates | 0.403 | The interaction between egfr and rin1 delineates a novel signal transduction pathway between egfr and its effectors, rin1, rab5a, and ras, which together coordinate and regulate both signaling and membrane trafficking. | SIGNOR-101530 |
P13500 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.403 | These findings suggest that both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1α is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia. | SIGNOR-251719 |
P08754 | P08172 | 0 | binding | up-regulates activity | 0.403 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256828 |
P16949 | Q9UQM7 | 0 | phosphorylation | down-regulates | 0.403 | Involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. In vitro, ser16 of recombinant human stathmin was phosphorylated also by purified cam kinase ii, and in vivo, cam kinase ii activity was indeed stimulated in cd2-... | SIGNOR-149640 |
P08754 | P08173 | 0 | binding | up-regulates activity | 0.403 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256829 |
Q01082 | Q8NG27 | 0 | ubiquitination | down-regulates | 0.403 | The present study indicates that praja, a ring finger e3 ubiquitin ligase, interacts with elf and ubiquitinates it. | SIGNOR-141216 |
Q06413 | Q9Y3R0 | 0 | binding | up-regulates | 0.403 | The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. | SIGNOR-83883 |
Q8N2W9 | O15033 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.403 | In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFβ signaling pathway through the site-specific ubiquitination of PIAS4.FIEL1 targets PIAS4 using a double locking mechanism that is facilitated by the kinases PKCζ and GS... | SIGNOR-275575 |
P09471 | Q99500 | 0 | binding | up-regulates activity | 0.403 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257263 |
P41162 | P28482 | 0 | phosphorylation | down-regulates activity | 0.403 | We have optimized a chemical genetic system using analog-sensitive ERK2, a form of ERK2 engineered to use an analog of adenosine 5'-triphosphate (ATP), to tag and isolate ERK2 substrates in vitro. This approach identified 80 proteins phosphorylated by ERK2, 13 of which are known ERK2 substrates. With this improved meth... | SIGNOR-262758 |
P55316 | Q9UGL1 | 0 | binding | up-regulates activity | 0.403 | Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. In a reporter assay system, PLU-1 has potent transcriptional repression activity. BF-1 and PAX9 also represses transcription in the same assay, but co-expression of PLU-1 with BF-1 or PAX9 si... | SIGNOR-223878 |
P49639 | O15550 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.403 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260019 |
Q9Y4C4 | O43164 | 0 | ubiquitination | up-regulates activity | 0.403 | These results suggest that the ubiquitylation of MFHAS1 by praja2 has a vital role in M1 macrophage polarization and promotes the transformation of M2 macrophages to M1 macrophages through both the JNK and p38 pathways. | SIGNOR-278559 |
P35222 | Q13308 | 0 | binding | down-regulates | 0.403 | Ptk7 has been strongly implicated in pcp and, like many pcp activators, is a negative regulator of beta-catenin-dependent wnt. | SIGNOR-199536 |
Q13363 | Q13153 | 0 | phosphorylation | down-regulates activity | 0.403 | Pak1 phosphorylates ctbp selectively on ser158 within a putative regulatory loop, triggering ctbp cellular redistribution and blocking ctbp ak1 superphosphorylates ctbp and inhibits ctbp dehydrogenase activitycorepressor functions. | SIGNOR-103943 |
P0DP23 | P06213 | 0 | phosphorylation | down-regulates | 0.403 | The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecu... | SIGNOR-24782 |
O14763 | P25490 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.403 | Depletion of FKBP51 impairs the acetylation status of YY1 and interferes with its binding on the DR5 promoter. The lack of the repressor activity of YY1 increases DR5 transcription and sensitizes melanoma cell to TRAIL-induced apoptosis. | SIGNOR-268793 |
P23771 | Q969H0 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.403 | Fbw7 promotes degradation of GATA3 in a Thr-156-dependent manner. | SIGNOR-276635 |
Q14934 | Q16539 | 0 | phosphorylation | down-regulates activity | 0.402 | P38 MAP kinase phosphorylates Ser168 and Ser170 of NFATc4. Mutational replacement of Ser168,170 with Ala promotes NFATc4 nuclear localization and increases NFATc4-mediated transcription activity. | SIGNOR-250107 |
Q15831 | P28482 | 0 | phosphorylation | down-regulates activity | 0.402 | Directly and/or through the activation of p90RSK, ERK phosphorylates LKB-1 at Ser325 and Ser428. The phosphorylation of LKB-1 causes the dissociation of LKB-1 from AMPK, resulting in the impaired activation of AMPK. | SIGNOR-209876 |
Q15208 | Q9Y2U5 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.402 | Our data suggest that Ser91 phosphorylation of STK38 by MEKK2 possibly blocks the interaction of calpain with STK38 or disrupts proper conformation for cleaving, thereby protecting STK38 from calpain-dependent degradation. | SIGNOR-279066 |
P40763 | P22455 | 0 | phosphorylation | up-regulates activity | 0.402 | Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (t... | SIGNOR-251142 |
Q9NS23 | Q969H4 | 0 | binding | up-regulates | 0.402 | Cnk1 binds to rassf1a and promotes apoptosis through a pathway that requires rassf1a and mst kinases. | SIGNOR-198432 |
P30679 | Q9UNW8 | 0 | binding | up-regulates activity | 0.402 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257444 |
P08151 | P41743 | 0 | phosphorylation | up-regulates activity | 0.402 | Although functioning downstream of SMO, aPKC-\u03b9/\u03bb phosphorylates and activates GLI1, resulting in maximal DNA binding and transcriptional activation [ xref ]. | SIGNOR-279262 |
P12931 | P23469 | 0 | dephosphorylation | up-regulates activity | 0.402 | PTPepsilonM activated c-Src kinase probably by directly dephosphorylating phospho-Tyr527, a negative regulatory site of c-Src. | SIGNOR-238074 |
O43524 | P67775 | 0 | dephosphorylation | up-regulates | 0.402 | Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. | SIGNOR-163680 |
Q06413 | Q9H1R3 | 0 | phosphorylation | up-regulates activity | 0.402 | Here, we show that phosphorylation of MEF2C on T(80) by skeletal myosin light chain kinase (skMLCK) enhances skeletal and not cardiac myogenesis. | SIGNOR-238118 |
P63096 | P25116 | 0 | binding | up-regulates | 0.402 | Upon proteolysis, the newly formed n terminus acts as a tethered ligand that activates the receptor and initiates signaling cascades through multiple g proteins (galfaq, galfai, and galfa12/13). | SIGNOR-196009 |
Q13671 | Q15139 | 0 | phosphorylation | down-regulates | 0.402 | Rin1 also binds to 14-3-3 proteins through a sequence including serine 351. Mutation of this residue abolished the 14-3-3 binding capacity of rin1 and led to more efficient blockade of ras-mediated transformation. The mutant protein, rin1(s351a), showed a shift in localization to the plasma membrane. Serine 351 is a su... | SIGNOR-113960 |
P46531 | P53350 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.402 | As shown in Fig. S4D, the C-terminal NOTCH1 fragment was readily phosphorylated by PLK1. Additionally, when the two putative phosphorylation sites, Ser-1791 and Ser-2349, were replaced by Ala, WT NOTCH1-IC but not the mutant was efficiently phosphorylated (Fig. S4E). We found that mutation of Ser-1791/2349 promotes NOT... | SIGNOR-277491 |
P63000 | Q5VT97 | 0 | gtpase-activating protein | down-regulates activity | 0.402 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260522 |
P11362 | P54764 | 0 | phosphorylation | up-regulates activity | 0.402 | EphA4 and FGFR1 heterodimer promotes FGFR1 signaling in glioma cell line.|Ligand stimulation of EphA4 stimulates FGFR1 phosphorylation and signaling. | SIGNOR-280007 |
O60282 | P54257 | 0 | binding | up-regulates activity | 0.402 | HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro | SIGNOR-264062 |
Q14344 | Q9HBW0 | 0 | binding | up-regulates | 0.402 | Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13. | SIGNOR-135837 |
O00750 | P14373 | 0 | ubiquitination | down-regulates | 0.402 | We now show that trim27 functions as an e3 ligase and mediates lysine 48 polyubiquitination of pi3kc2_, leading to a decrease in pi3k enzyme activity. | SIGNOR-177935 |
P04350 | Q14980 | 0 | binding | up-regulates | 0.402 | Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. | SIGNOR-117025 |
P27986 | Q13322 | 0 | binding | up-regulates activity | 0.402 | Grb10 transduces signal from FLT3 by direct interaction with p85 and Ba/F3-FLT3-ITD cells expressing Grb10 exhibits higher STAT5 activation | SIGNOR-255945 |
Q9HCU9 | O43791 | 0 | ubiquitination | down-regulates quantity | 0.402 | Intriguingly, BRMS1 turns out to be a potent substrate that is ubiquitinated by the Cul3-SPOP complex. Knockdown of SPOP increases the level of BRMS1 protein and represses the expression of BRMS1 repressive target genes such as OPN and uPA in breast cancer cells. | SIGNOR-268857 |
O95837 | P11229 | 0 | binding | up-regulates activity | 0.402 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257130 |
P38936 | Q9P1W9 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.402 | Pim-2 phosphorylation of p21(cip1/waf1) enhances its stability and inhibits cell proliferation in hct116 cellsere we demonstrate that like pim-1, pim-2 also phosphorylates the cell cycle inhibitor p21(cip1/waf1) (p21) on thr145 in vitro and in vivo | SIGNOR-164646 |
P40763 | P16591 | 0 | phosphorylation | up-regulates activity | 0.402 | Replacing the unique 43-amino acid-long N-terminal tail of p51 (ferT) with a parallel segment from the N-terminal tail of p94 (fer) did not change the subcellular localization of p51 (ferT) but enabled it to activate Stat3.|When combined with immunoprecipitation analysis, this assay showed that p94 (fer) can lead to th... | SIGNOR-279713 |
Q13153 | P28482 | 0 | phosphorylation | down-regulates activity | 0.402 | We also show that ERK2 phosphorylates PAK1 on Thr(212) in vitro and that Thr(212) is phosphorylated in smooth muscle cells following PDGF-BB treatment in an adhesion- and MEK/ERK-dependent fashion. Expression of a phosphomimic variant, PAK-T212E, does not alter ERK association, but markedly attenuates downstream ERK si... | SIGNOR-249432 |
P40429 | O43293 | 0 | phosphorylation | up-regulates | 0.402 | Zipk phosphorylates l13a in vitro / l13a is phosphorylated on ser77 in vitro | SIGNOR-182117 |
P40763 | Q00535 | 0 | phosphorylation | up-regulates | 0.402 | We report here that the cdk5/p35 complex associates with stat3 and phosphorylates stat3 on the ser-727 residue in vitro and in vivo. Ser phosphorylation of stat3 and transcription of stat3 target genes, such as c-fos and junb, in a cdk5-dependent manner. | SIGNOR-124325 |
P63000 | Q8N103 | 0 | gtpase-activating protein | down-regulates activity | 0.402 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260524 |
Q9H190 | P30408 | 0 | relocalization | up-regulates activity | 0.402 | TM4SF1 functions as a membrane adaptor connecting DDR1 to syntenin2. | SIGNOR-272401 |
Q92597 | Q96BR1 | 0 | phosphorylation | down-regulates activity | 0.402 | It has been shown that SGK3 phosphorylation of NDRG1 primes for subsequent phosphorylation by GSK-3beta.|Since NDRG1 is a direct SGK substrate, this correlation suggests that SGK3 activation and signaling may modulate NDRG1 degradation. | SIGNOR-279282 |
Q16623 | Q9ULU8 | 0 | binding | up-regulates activity | 0.402 | CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1 | SIGNOR-264336 |
P02462 | Q8NBJ5 | 0 | glycosylation | up-regulates activity | 0.402 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261155 |
P40763 | P07332 | 0 | phosphorylation | up-regulates activity | 0.402 | Fes also induced Tyr 705 phosphorylation and DNA binding activity of STAT3, in agreement with the idea that Fes can regulate transcriptional activation through Fes dependent phosphorylation of transcription factors.On the basis of these findings, we propose that Fes activation of critical transcriptional regulators suc... | SIGNOR-278937 |
Q86XR7 | Q9NR96 | 0 | binding | up-regulates activity | 0.401 | To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TL... | SIGNOR-266750 |
P10242 | P19338 | 0 | binding | down-regulates activity | 0.401 | We identify nucleolin as one of the nuclear polypeptides that interact specifically with the A-Myb and c-Myb. We show that the interaction of nucleolin with Myb is functional because co-transfection of nucleolin down-regulates Myb transcriptional activity. | SIGNOR-221236 |
Q06609 | Q6PCD5 | 0 | ubiquitination | up-regulates activity | 0.401 | Rad51 directly interacts with the N-terminal of RFWD3 and is ubiquitinated by RFWD3. | SIGNOR-278543 |
P08754 | P30411 | 0 | binding | up-regulates activity | 0.401 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256838 |
P19429 | P67775 | 0 | dephosphorylation | down-regulates | 0.401 | The major phosphatase thought to dephosphorylate ctni and phospholamban is type 2a protein phosphatase (pp2a) [61]. Activation of pp2a and ensuing dephosphorylation of regulatory proteins is involved in the anti-adrenergic effects of adenosine and muscarinic receptor activation see also fig2. | SIGNOR-134601 |
P40763 | O43293 | 0 | phosphorylation | up-regulates activity | 0.401 | ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. | SIGNOR-279702 |
Q8WYH8 | P24941 | 0 | phosphorylation | up-regulates quantity | 0.401 | We report that ING5 is phosphorylated in a cell cycle dependent manner by CDK2 at T152 (Figs 1 and 3). | SIGNOR-279447 |
P33993 | Q05086 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.401 | The characterization of this interaction in turn led to the discovery that Mcm7 is a substrate for both E6-AP-dependent and -independent ubiquitination and is specifically targeted for degradation by the 26 S proteasome. | SIGNOR-272543 |
P36952 | P10275 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.401 | In addition, androgen receptor (AR) can recognize and bind to the ARE element, and then inhibit the activity of maspin promoter | SIGNOR-253685 |
P29353 | P17252 | 0 | phosphorylation | up-regulates activity | 0.401 | Among them, Ser(29) in p52(Shc) (equivalent to Ser(138) in p66(Shc)) was phosphorylated only after TPA stimulation. Phosphorylation of this site together with the intact phosphotyrosine-binding domain was essential for ShcA binding to the protein-tyrosine phosphatase PTP-PEST. TPA-induced ShcA phosphorylation at this s... | SIGNOR-249150 |
Q15382 | Q8IW41 | 0 | phosphorylation | down-regulates activity | 0.401 | Phosphorylation of Rheb at Ser 130 by PRAK impairs the nucleotide-binding ability of Rheb and inhibits Rheb-mediated mTORC1 activation. | SIGNOR-276313 |
P30679 | Q15077 | 0 | binding | up-regulates activity | 0.401 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257277 |
P00533 | P35790 | 0 | binding | up-regulates activity | 0.401 | We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-depende... | SIGNOR-266352 |
Q96CV9 | Q8IYU2 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.401 | Here we report that tumor suppressor HACE1, a ubiquitin ligase, ubiquitylates OPTN and promotes its interaction with p62 and SQSTM1 to form the autophagy receptor complex, thus accelerating autophagic flux.|Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression.|HAC... | SIGNOR-278748 |
P38435 | O43852 | 0 | binding | down-regulates activity | 0.401 | Results are presented that demonstrate that the endoplasmic reticulum chaperone protein calumenin is associated with gamma-carboxylase and inhibits its activity. | SIGNOR-265910 |
P63027 | P37840 | 0 | binding | down-regulates quantity | 0.401 | The normal function of the small presynaptic protein α-synuclein (α-syn) is of exceptional interest, not only in the context of neurodegeneration, but also as a cytosolic regulator of neurotransmission. we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergen... | SIGNOR-264104 |
Q9BZS1 | P06239 | 0 | phosphorylation | down-regulates | 0.401 | Lck phosphorylated tyr-342 of foxp3 by immunoprecipitation and in vitro kinase assay, and the replacement of tyr-342 with phenylalanine (y342f) abolished the ability to suppress mmp9 expression. | SIGNOR-203089 |
Q13950 | Q8WYB5 | 0 | binding | up-regulates | 0.401 | Moz and morf both interact with runx2 / while morf does not acetylate runx2, its sm domain potentiates runx2-dependent transcriptional activation. | SIGNOR-117335 |
Q9Y4G8 | P46934 | 0 | ubiquitination | down-regulates quantity | 0.401 | In line with the previous result (XREF_FIG), overexpression of NEDD4-1 reduced the level of CNrasGEF significantly (XREF_FIG).|NEDD4-1 ubiquitinates CNrasGEF in glioma cells. | SIGNOR-278705 |
P12830 | P68400 | 0 | phosphorylation | up-regulates activity | 0.401 | Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. | Under these conditions, phosphorylation of the E-cadherin double mutant S853A/S855A was reduced by 25% as compared with wt E-cadherin. | Expression of the E-cadherin double mutant S853A/S85... | SIGNOR-250840 |
Q14940 | P49407 | 0 | relocalization | down-regulates activity | 0.401 | Internalization of the Na(+)/H(+) exchanger NHE5 into recycling endosomes is enhanced by the endocytic adaptor proteins beta-arrestin1 and -2, best known for their preferential recognition of ligand-activated G protein-coupled receptors (GPCRs) | SIGNOR-275505 |
P20749 | Q9BZK7 | 0 | ubiquitination | down-regulates | 0.401 | We also defined the e3 ligase tblr1 as a protein involved in bcl-3 degradation | SIGNOR-166111 |
P15498 | P00519 | 0 | phosphorylation | up-regulates | 0.401 | Thus, the c-terminal tail of vav serves as a direct substrate of bcr-abl in vitro. | SIGNOR-114091 |
P13569 | Q8IWU2 | 0 | phosphorylation | down-regulates activity | 0.401 | The present study discovered that in human airway epithelial cells CFTR endocytosis is regulated by the LMTK2-mediated phosphorylation of CFTR-Ser737 that decreases the cell surface density of CFTR Cl\u2212 channels and inhibits CFTR-mediated Cl\u2212 secretion.|Together, the above results demonstrate that the LMTK2 ph... | SIGNOR-278227 |
P08123 | P03956 | 0 | cleavage | down-regulates quantity by destabilization | 0.401 | In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. | SIGNOR-272337 |
P08754 | P25116 | 0 | binding | up-regulates activity | 0.401 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256875 |
P04637 | Q9UNH5 | 0 | dephosphorylation | down-regulates activity | 0.401 | The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53|. Furthermore, the hCdc14 phosphatases were found to dephosphorylate p53 specifically at the p34Cdc2/clb phosphorylation site (p53-phosphor-Ser315)|Earlier studies showed that Ser315 phosphorylation increases the sequence-sp... | SIGNOR-248828 |
P06730 | Q13490 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.401 | We found that endogenous eIF4E was ubiquitinated by cIAP1, and ubiquitinated eIF4E accumulated upon MG132 treatment. | SIGNOR-278741 |
P28288 | P28328 | 0 | ubiquitination | up-regulates activity | 0.401 | PEX5 and PMP70 are ubiquitinated by PEX2 during amino acid starvation. | SIGNOR-278708 |
P51617 | O15524 | 0 | binding | down-regulates | 0.401 | Coimmunoprecipitation analyses demonstrated association of socs-1 with irak...This Finding suggests that socs-1 might suppress myd88-dependent signal pathways at least by binding to irak | SIGNOR-95528 |
Q16584 | P31749 | 0 | phosphorylation | down-regulates | 0.4 | Negative regulation of mixed lineage kinase 3 by protein kinase b/akt leads to cell survivalthe expression of activated akt1 inhibits mlk3-mediated cell death in a manner dependent on serine 674 phosphorylation. | SIGNOR-252592 |
Q9BXM7 | Q16891 | 0 | binding | up-regulates activity | 0.4 | MIC60 Is Crucial for Parkin Recruitment and Transiently Interacts with PINK1 | SIGNOR-266301 |
Q9Y566 | Q06787 | 0 | post transcriptional regulation | up-regulates quantity | 0.4 | These results point toward a novel mechanism by which FUS targets neuronal mRNA and given that these PSD-95 and Shank1 3'-UTR G quadruplex structures are also targeted by the fragile X mental retardation protein (FMRP), they raise the possibility that FUS and FMRP might work together to regulate the translation of thes... | SIGNOR-262109 |
O43463 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.4 | A recent report showed that the p53 inducible E3 ligase MDM2 causes SUV39H1 degradation.|Furthermore, it was reported that MDM2 can ubiquitinate and degrade SUV39H1. | SIGNOR-278631 |
P35226 | O43791 | 0 | binding | up-regulates activity | 0.4 | Here, we describe an E3 ubiquitin ligase consisting of SPOP and CULLIN3 that is able to ubiquitinate the PcG protein BMI1 and the variant histone MACROH2A1. To investigate whether BMI1 can form a complex with SPOP and CULLIN3 in vivo, we reconstituted the complex in 293HEK cells. We find that BMI1 readily immunoprecipi... | SIGNOR-272658 |
P50148 | O43603 | 0 | binding | up-regulates activity | 0.4 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257020 |
Q16236 | P06241 | 0 | phosphorylation | down-regulates quantity | 0.4 | Fyn phosphorylates Nrf2 Y568, resulting in nuclear export and degradation of Nrf2.|Fyn phosphorylates Nrf2Y568 resulting in nuclear export and degradation of Nrf2. | SIGNOR-278358 |
O14492 | P31749 | 0 | phosphorylation | up-regulates activity | 0.4 | This study identifies APS as a novel physiological substrate for PKB and the first serine phosphorylation site on APS | SIGNOR-252557 |
P16112 | Q99542 | 0 | cleavage | down-regulates quantity by destabilization | 0.4 | Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)|In this study we investigated the ability of MMP-19 and MMP-20 to cleave two of the macromolecules characterising the cartilage ECM, namely aggrecan and the cartilage oligomeric matrix protein (COMP). Both MMPs hydrolysed... | SIGNOR-266978 |
P42336 | Q9UBI6 | 0 | binding | up-regulates | 0.4 | We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the ... | SIGNOR-141795 |
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