IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P63279 | P05412 | 1 | sumoylation | down-regulates activity | 0.42 | We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229. Sumoylation of c-Fos preferentially occurs in the context of c-Jun/c-Fos heterodimers.|Inhibition... | SIGNOR-263001 |
P24158 | P25116 | 1 | cleavage | down-regulates activity | 0.42 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263577 |
O00712 | Q14938 | 1 | transcriptional regulation | up-regulates quantity | 0.42 | We report that, in the absence of Nfia or Nfib, there is a marked reduction in the spinal cord expression of NFIX, and that NFIB can transcriptionally activate Nfix expression in vitro. These data demonstrate that NFIX is part of the downstream transcriptional program through which NFIA and NFIB coordinate gliogenesis ... | SIGNOR-268870 |
P12931 | P29474 | 1 | phosphorylation | up-regulates activity | 0.42 | Two kinases, i.e. abelson-tyrosine protein kinase (ABL)1 and Src were identified as eNOS Tyr81 kinases as their inhibition and down-regulation significantly reduced the basal and Yoda1-induced tyrosine phosphorylation and activity of eNOS. | SIGNOR-277520 |
P45983 | O15350 | 1 | phosphorylation | up-regulates activity | 0.42 | Therefore, it is likely that p73 recruitment to the \u0394Np73 promoter is mediated by its JNK-1-dependent phosphorylation. | SIGNOR-279219 |
P27361 | P14598 | 1 | phosphorylation | up-regulates | 0.42 | Upon activation, several serine residues on the cytosolic oxidase subunit p47phox become phosphorylated. Mitogen-activated protein kinase phophorylated only the peptide containing ser345/348. | SIGNOR-40821 |
Q13315 | Q7L7X3 | 1 | phosphorylation | up-regulates | 0.42 | The dna damage kinase ataxia telangiectasia mutated (atm) phosphorylates taos in vitro;radiation induces phosphorylation of tao on a consensus site for phosphorylation by the atmprotein kinase in cells. | SIGNOR-154171 |
Q13362 | P27361 | 2 | binding | down-regulates | 0.42 | B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk | SIGNOR-144328 |
Q8NFP9 | Q92796 | 1 | binding | up-regulates activity | 0.42 | Interestingly, a recent proteomic analysis (Lauks et al., 2012) revealed that Nbea binds SAP102, which interacts with glutamate receptors early in the biosynthetic route and regulates their targeting. This finding, along with the interaction of Nbea with the glycine receptor beta subunit (del Pino et al., 2011), furthe... | SIGNOR-266004 |
Q00535 | P07197 | 1 | phosphorylation | down-regulates quantity | 0.42 | Converse to the effect of PKA overexpression, overexpression of CDK5 and its activator, p35, decreased the association between spinophilin and NF-M as well as the expression of NF-M.|Moreover, CDK5 phosphorylates NF-M [ xref ], and this was also apparent in our data, given a dramatic molecular weight shift in the NF-M ... | SIGNOR-279683 |
Q9UHD2 | P42345 | 1 | phosphorylation | up-regulates activity | 0.42 | They later demonstrated that TANK-binding kinase 1 (TBK1) interacts with and phosphorylates mTOR on Ser 2159, to promote catalytic activity of mTOR [216]. | SIGNOR-278237 |
Q7Z6Z7 | O95140 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.42 | AMBRA1 regulates mitophagy at two critical steps. Upon mitophagy stimulation, AMBRA1 mediates the HUWE1 E3 ubiquitin ligase translocation from cytosol to mitochondria (light blue). AMBRA1 acts as a cofactor for HUWE1 E3 ubiquitin ligase activity, favouring its binding to its substrate MFN2 (and maybe other OMM substrat... | SIGNOR-272978 |
P31751 | P98170 | 1 | phosphorylation | up-regulates | 0.42 | Here, we demonstrate that akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. Phosphorylation of xiap by akt protects xiap from ubiquitination and degradation in response to cisplatin. Moreover, autoubiquitination of x... | SIGNOR-119492 |
Q13164 | P14921 | 1 | phosphorylation | up-regulates | 0.42 | 9-cis retinoid x receptor alpha (rxr alpha) interacted with erk2 but not erk5 in intact cells, whereas ets-1 interacted preferentially with erk5. Increased phosphorylation of rxr alpha and ets-1 was detected in response to 1,25d. Activated erk2 and erk5 specifically phosphorylated rxr alpha and ets-1, respectively.Muta... | SIGNOR-88666 |
P52306 | P62834 | 1 | binding | up-regulates | 0.42 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171482 |
P27361 | Q13362 | 2 | phosphorylation | down-regulates | 0.42 | Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. | SIGNOR-144317 |
Q8NE79 | Q15836 | 1 | binding | up-regulates activity | 0.42 | Taken together, these data demonstrate that Bves interacts with VAMP3 and facilitates receptor recycling both in vitro and during early development. | SIGNOR-237771 |
Q9UH99 | P20339 | 1 | binding | up-regulates activity | 0.42 | Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 | SIGNOR-261309 |
P11309 | P36888 | 1 | phosphorylation | up-regulates quantity | 0.42 | Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication[...]Pim-1 inhibition also decreased phosphorylation of FLT3 at tyrosine 591 and of STAT5, and expression of Pim-1 itself, consistent with inhibition of the FLT3-I... | SIGNOR-259927 |
Q7KZI7 | Q7L804 | 1 | phosphorylation | up-regulates | 0.42 | We identified the kinase that phosphorylated rab11-fip2 as mark2/emk1/par-1balpha (mark2), and recombinant mark2 phosphorylated rab11-fip2 only on serine 227. In calcium switch assays, cells expressing rab11-fip2(s227a) showed a defect in the timely reestablishment of p120-containing junctional complexes. | SIGNOR-147118 |
Q00535 | Q8N5V2 | 1 | phosphorylation | up-regulates activity | 0.42 | Importantly, ephexin1, a Rho GEF, is phosphorylated by Cdk5 in vivo . | SIGNOR-279021 |
P06493 | Q8NEB9 | 1 | phosphorylation | down-regulates | 0.42 | We show that vps34 is phosphorylated on thr159 by cdk1, thr159 phosphorylation negatively regulates the ptdins3 kinase activity of vps34 and autophagy | SIGNOR-165768 |
O15169 | Q9Y6R4 | 1 | binding | up-regulates | 0.42 | Mekk4, also binds to axin in vivo and mediates axin-induced jnk activation. | SIGNOR-104003 |
Q13177 | Q9BUB5 | 1 | phosphorylation | down-regulates activity | 0.42 | Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. When 293T cells are subjected to apoptotic induction by hydrogen peroxide, Mnk1 is phosphorylated at both Thr(22) and Ser(27). These results indicate a role for Pak2 in the down-regulation of translat... | SIGNOR-250221 |
P34925 | O14641 | 1 | binding | up-regulates | 0.419 | Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. | SIGNOR-129571 |
Q96L34 | P10636 | 1 | phosphorylation | down-regulates activity | 0.419 | AMPK phosphorylation inhibits tau binding of microtubules. In order to study further the phosphorylation of tau by AMPK, we compared phosphorylation of tau by MARK4 or AMPK using a panel of phospho-tau antibodies (Figure 2A). Five phosphorylation sites common to both kinases were identified (Thr231, Ser262, Ser356, Ser... | SIGNOR-273935 |
P46934 | P42261 | 1 | ubiquitination | down-regulates quantity | 0.419 | Finally, we show that ubiquitination of GluA1 by Nedd4-1 becomes more prevalent as neurons mature.|The ability of Nedd4-1 to reduce surface GluA1 levels required its ligase activity, since co-expression of a catalytically-inactive version of Nedd4-1 (Nedd4-1 CS) did not decrease surface GluA1 levels . | SIGNOR-278572 |
Q8TEW6 | P12931 | 1 | binding | up-regulates | 0.419 | Insulin receptor-phosphorylated irs5/dok4 associates with rasgap, crk, src, and fyn, but not phosphatidylinositol 3-kinase p85, grb2, shp-2, nck, or phospholipase cgamma src homology 2 domains, and activates mapk in cells. | SIGNOR-101002 |
P00519 | P00533 | 1 | phosphorylation | up-regulates | 0.419 | we show that activated Abl phosphorylates the EGFR primarily on tyrosine 1173Furthermore, we show that activated Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the... | SIGNOR-149277 |
P10827 | P13631 | 2 | binding | up-regulates | 0.419 | We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. | SIGNOR-133246 |
Q9H2X6 | O15297 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.419 | HIPK2 phosphorylates WIP1 at Ser54 and Ser85, and phosphorylated WIP1 is subject to proteasomal degradation so that WIP1 is maintained at low levels. | SIGNOR-278230 |
Q96L34 | P10636-5 | 1 | phosphorylation | down-regulates activity | 0.419 | AMPK phosphorylation inhibits tau binding of microtubules. In order to study further the phosphorylation of tau by AMPK, we compared phosphorylation of tau by MARK4 or AMPK using a panel of phospho-tau antibodies (Figure 2A). Five phosphorylation sites common to both kinases were identified (Thr231, Ser262, Ser356, Ser... | SIGNOR-273932 |
P46934 | Q96NT3 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.419 | The E3 ligase NEDD4 regulates GUCD1 degradation. many polyubiquitinylated species of GUCD1 appeared as high molecular weight forms, suggesting that GUCD1 is degraded by the proteasome, after polyubiquitin chain formation, in the presence of NEDD4-1. | SIGNOR-272846 |
P13631 | P10827 | 2 | binding | up-regulates | 0.419 | We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs | SIGNOR-133237 |
O15264 | Q6JBY9 | 1 | phosphorylation | down-regulates activity | 0.419 | CapZIP was also phosphorylated rapidly by SAPK3/p38γ and SAPK4/p38δ, and even faster and more extensively by JNK1α1, these protein kinases phosphorylating CapZIP in vitro to >3, approx. 2 and >5 mol of phosphate/mol of protein respectively within a few minutes. Following tryptic digestion and C18 chromatography, furthe... | SIGNOR-263084 |
Q9UF56 | Q9UMX1 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.419 | Here, we show that Fbxl17 (F-box and leucine-rich repeat protein 17) targets Sufu for proteolysis in the nucleus. The ubiquitylation of Sufu, mediated by Fbxl17, allows the release of Gli1 from Sufu for proper Hh signal transduction | SIGNOR-253545 |
P22392 | O15554 | 1 | phosphorylation | up-regulates | 0.419 | We previously showed that nucleoside diphosphate kinase beta (ndpk-b), a mammalian histidine kinase, is required for kca3.1 channel activation in human cd4 t lymphocytes. | SIGNOR-181083 |
Q13315 | P46527 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.419 | We also uncovered that ATM phosphorylates p27Kip1 on a previously uncharacterized residue (Ser-140), which leads to its stabilization after induction of DNA double-strand breaks. | SIGNOR-279392 |
P49356 | P01116 | 1 | null | up-regulates activity | 0.419 | Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. | SIGNOR-242556 |
P19793 | P35222 | 1 | binding | down-regulates | 0.419 | Rxr agonists still inactivated endogenous beta-catenin via rxr alpha. | SIGNOR-101293 |
P06493 | Q14493 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.419 | Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase | SIGNOR-265258 |
O14965 | O95239 | 1 | phosphorylation | up-regulates activity | 0.419 | We show that Aurora A phosphorylates the condensin I-dependent pool of KIF4A and thus actively promotes chromosome congression from the spindle poles to the metaphase plate. In vitro kinase assays showed that recombinant KIF4A can be phosphorylated by Aurora A and that this activity is inhibited by the specific Aurora ... | SIGNOR-265993 |
P50148 | Q9NZN5 | 1 | binding | up-regulates activity | 0.419 | Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. | SIGNOR-256520 |
Q9H1C0 | P08754 | 1 | binding | up-regulates activity | 0.419 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256861 |
Q5JTC6 | P49841 | 1 | relocalization | up-regulates activity | 0.419 | Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. | SIGNOR-171892 |
Q9P2P5 | Q8IY63 | 1 | ubiquitination | up-regulates activity | 0.419 | These results clearly indicate that HECW2 ubiquitinates AMOTL1 with K63-linked polyubiquitin chains.|Unlike NEDD4.2, HECW2 targeted AMOTL1 and promoted its stability. | SIGNOR-278811 |
Q14012 | Q9UQL6 | 1 | phosphorylation | down-regulates | 0.419 | Camk phosphorylates serines -259 and -498 in hdac5, which subsequently serve as docking sites for 14-3-3. Our studies suggest that 14-3-3 binding to hdac5 is required for camk-dependent disruption of mef2hdac complexes and nuclear export of hdac5, and implicate 14-3-3 as a signal-dependent regulator of muscle cell diff... | SIGNOR-85022 |
P45984 | Q14934 | 1 | phosphorylation | up-regulates activity | 0.419 | Here, we showed that the nuclear factor of activated T3 (NFAT3) is phosphorylated by JNK1 or JNK2 at Ser(213) and Ser(217), which are located in the conserved SP motif.|Moreover, a 3xNFAT-luc reporter gene assay indicated that NFAT3 transcriptional activity was increased in a dose-dependent manner by JNK1 or JNK2. | SIGNOR-280036 |
P27361 | Q13485 | 1 | phosphorylation | up-regulates | 0.419 | Our results suggest that map kinase can phosphorylate thr276 of smad4 and that phosphorylation can lead to enhanced tgf-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of smad4. | SIGNOR-101664 |
P06493 | Q8IZP0 | 1 | phosphorylation | down-regulates activity | 0.419 | We identified serine 216 of Abi1 as a target of CDK1/cyclin B kinase that is phosphorylated in cells at the onset of mitosis.|Bcr-Abl-induced actin polymerization requires the Abi1 pathway, as the blockade of the signal transduction from Bcr-Abl to Abi1 abolishes the F-actin assembly|serine phosphorylation of Abi1 by C... | SIGNOR-264421 |
Q96L34 | P10636-4 | 1 | phosphorylation | down-regulates activity | 0.419 | AMPK phosphorylation inhibits tau binding of microtubules. In order to study further the phosphorylation of tau by AMPK, we compared phosphorylation of tau by MARK4 or AMPK using a panel of phospho-tau antibodies (Figure 2A). Five phosphorylation sites common to both kinases were identified (Thr231, Ser262, Ser356, Ser... | SIGNOR-273934 |
P01137 | P62736 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.419 | A TGF-β1 response element that has a sequence different to that known for Smad binding has been identified in the α- SM actin promoter and seems to be essential for expression of α-SM actin in both SM cells 72 and myofibroblasts73 . How TGF-β1 activates expression of α-SM actin through this TGF-β1 control element is, a... | SIGNOR-277681 |
P48729 | Q12778 | 1 | phosphorylation | down-regulates | 0.418 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity | SIGNOR-183658 |
P50613 | P13631 | 1 | phosphorylation | up-regulates activity | 0.418 | RARg Is Phosphorylated by cdk7 in Its B and F Regions | Mutation into alanine of Ser-77 and Ser-79 located in the A/B region reduced the transcriptional activity of hRARg1 (Fig. 9A), confirming that these phosphorylation sites are required for optimal transcription. | SIGNOR-259853 |
P11309 | P27448 | 1 | phosphorylation | down-regulates | 0.418 | Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1. | SIGNOR-128264 |
Q9P0L2 | P11137 | 1 | phosphorylation | down-regulates activity | 0.418 | Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. | SIGNOR-250166 |
P05771 | Q16236 | 1 | phosphorylation | up-regulates | 0.418 | Phosphorylation of nrf2 at ser-40 by protein kinase c regulates antioxidant response element-mediated transcription / recently we reported evidence for the involvement of protein kinase c (pkc) in phosphorylating nrf2 and triggering its nuclear translocation in response to oxidative stress | SIGNOR-91830 |
Q6ZUJ8 | P42338 | 1 | binding | up-regulates | 0.418 | This accumulation of tyrosine-phosphorylated bcap at the membrane with its associated pi3k would then allow for the catalysis of ptd ins p2 to ptd ins p3 and downstream pi3k-dependent signals. Therefore, bcap is an essential activator of the pi3k pathway downstream of tlr signaling, providing a brake to limit potential... | SIGNOR-191667 |
Q96KB5 | Q96S44 | 1 | phosphorylation | up-regulates activity | 0.418 | In this study, we provide evidence showing that TOPK promotes metastasis of colorectal carcinoma, which is mediated through its phosphorylation of PRPK at Ser250.|Therefore, we conclude that TOPK directly promotes metastasis of colorectal cancer by modulating PRPK. | SIGNOR-278236 |
P12931 | O14746 | 1 | phosphorylation | down-regulates | 0.418 | Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via src kinase family-dependent phosphorylation of tyrosine 707 | SIGNOR-102097 |
Q96S59 | Q9Y463 | 1 | binding | down-regulates activity | 0.418 | Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M. | SIGNOR-238008 |
Q8IYD8 | Q92547 | 1 | relocalization | up-regulates | 0.418 | The enzymatic activity of fan cm is then required to remodel and stabilize the fork to allow topbp1 access to activate atr , in a 9-1-1-independent manner. | SIGNOR-164765 |
O60674 | Q6N021 | 1 | phosphorylation | up-regulates activity | 0.418 | Specifically, cytokine receptor-associated JAK2 phosphorylates TET2 at tyrosines 1939 and 1964. Phosphorylated TET2 interacts with the erythroid transcription factor KLF1, and this interaction with TET2 is increased upon exposure to erythropoietin. | SIGNOR-277289 |
O43303 | O15182 | 1 | binding | up-regulates activity | 0.418 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-265968 |
Q03468 | P27695 | 1 | binding | down-regulates activity | 0.418 | CSB stimulates the AP site incision activity of APE1 on normal (i.e. fully paired) and bubble AP-DNA substrates, with the latter being more pronounced (up to 6-fold). This activation is ATP-independent, and specific for the human CSB and full-length APE1 protein. CSB and APE1 were also found in a common protein complex... | SIGNOR-251932 |
P26447 | P35579 | 1 | binding | down-regulates activity | 0.418 | Our results show that S100A4 regulates cell polarization during directed motility by affecting the localization of protrusions through interactions with myosin-IIA, with S100A4 expressing cells displaying few side protrusions and extensive forward protrusions during chemotaxis compared with control cells. The mechanism... | SIGNOR-269282 |
P24941 | P49916 | 1 | phosphorylation | down-regulates | 0.418 | Dna ligase iii_ is specifically phosphorylated in replicating cells by the cell cycle kinase cdk2. However, in response to oxidative dna damage, dna ligase iii_ is dephosphorylated in a pathway that is dependent upon the dna damage-activated, phosphatidylinositol 3-phosphate (pi3)1-related kinase atm. | SIGNOR-150121 |
P32249 | P63096 | 1 | binding | up-regulates activity | 0.418 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256715 |
P18031 | P35968 | 1 | dephosphorylation | down-regulates activity | 0.418 | This led to increased PTPN1 (PTP1b)-mediated dephosphorylation of VEGFR2 at Y 1175 , the site involved in activating ERK signaling. | SIGNOR-277011 |
Q92835 | P43405 | 1 | dephosphorylation | down-regulates activity | 0.418 | An adaptor protein Dok-3 mediates the suppressive function of LYN. The Dok-3 phosphorylated by LYN upon BCR stimulation forms a complex with GRB2, which allows it to enter into the signalosome and associate with activation of SHIP protein. This translocation facilitates the efficient inhibition of PLCc2 and SYK from ac... | SIGNOR-268456 |
P06213 | Q14451 | 1 | binding | up-regulates | 0.418 | Insulin induces the ir-grb7 interaction in cells expressing physiological levels of the proteins, suggesting that grb7 is implicated in insulin signaling. | SIGNOR-77153 |
P57059 | Q6UUV7 | 1 | phosphorylation | down-regulates | 0.418 | These results suggested that sik1 could phosphorylate all torcs and thereby repress their transactivation activities. | SIGNOR-147703 |
Q15637 | Q01844 | 1 | binding | down-regulates | 0.418 | Here we report that zfm1 also interacts withews / overexpression of zfm1 in hepg2 cells represses the transactivation of reporter gene expression driven by gal4-ews-ntd fusion protein and this repression correlates with zfm1 binding to ews. | SIGNOR-58928 |
Q9NRM7 | P38936 | 1 | phosphorylation | down-regulates quantity | 0.417 | Phosphorylation by Lats2 induces degradation of p21 and promotes apoptosis.|Subsequently, Lats2 phosphorylates p21 at S146. | SIGNOR-279530 |
Q8NG66 | P30304 | 1 | phosphorylation | down-regulates | 0.417 | Nek11 regulates cdc25a degradation and the ir-induced g2/m checkpointincubation of wild-type cdc25a with nek11 led to a marked increase in phosphorylation of ser 82 and 88 as detected with the phosphospecific antibody recognizing these sites | SIGNOR-187867 |
Q9HCK8 | O96020 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.417 | In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidylate synthetase (TYMS), two genes expressed in the G1/S transition of the cell cycle. CHD8 was also able to co-activate the CCNE2 promoter ... | SIGNOR-268804 |
O15530 | P17252 | 1 | phosphorylation | up-regulates | 0.417 | One of the most studied events controlled by ptdins(3,4,5)p3, comprises the activation of a of agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regula... | SIGNOR-126066 |
P17252 | Q05586 | 1 | phosphorylation | up-regulates activity | 0.417 | Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. The results show that PKC alpha phosphorylates preferentially S896 and PKC gamma preferentially S890. | SIGNOR-263177 |
O75116 | Q15306 | 1 | phosphorylation | up-regulates | 0.417 | Carock2 phosphorylated irf4 at either of 2 distinct phosphorylation sites, s446 and s447 / rock2-mediated phosphorylation of irf4 regulated the synthesis of il-17 and il-21 and the differentiation of th17 cells. | SIGNOR-167471 |
P28702 | P43354 | 1 | binding | up-regulates | 0.417 | The recent discovery that the nuclear transcription factor, nurr1, in heterodimeric tandem with rxr, is unequivocally necessary for the expression of dopaminergic neurons | SIGNOR-58309 |
Q13153 | O14965 | 1 | phosphorylation | up-regulates | 0.417 | The upstream pak1 kinase can phosphorylate aurora a at t288, autophosphorylation appears to be the essential mode of activation. Our experiments suggest that phosphorylation of t288 is important for regulation of the aurora2 kinase both for its activity and its stability | SIGNOR-205110 |
P12931 | P46934-4 | 1 | phosphorylation | up-regulates activity | 0.417 | Activation of c-Src by epidermal growth factor (EGF) also promoted tyrosine phosphorylation and enhanced the activity of NEDD4. | SIGNOR-276860 |
P23471 | Q9NRY4 | 1 | dephosphorylation | down-regulates activity | 0.417 | Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP| Furthermore, Ptprz selectively dephosphorylated pY1105 of p190 RhoGAP in vitro, and the tyrosine phosphorylation at Y1105 controls p190 RhoGAP activity in vivo. | SIGNOR-248451 |
P12931 | Q15746 | 1 | phosphorylation | up-regulates | 0.417 | Ec mlck-1 is phosphorylated by p60(src) on tyr(464) and tyr(471), resulting in a 2- to 3-fold increase in ec mlck-1 enzymatic activity. | SIGNOR-85009 |
Q96K30 | Q06330 | 1 | binding | down-regulates | 0.417 | Thus, we propose that rita acts as a negative modulator of the notch signalling pathway, controlling the level of nuclear rbp-j/cbf-1, where its amounts are limiting. | SIGNOR-170089 |
P18031 | P29320 | 1 | dephosphorylation | down-regulates activity | 0.417 | Nevertheless, the finding that phosphorylation of the activation loop tyrosine (EphA3-Y779), a recently identified PTP1B substrate (Mertins et al., 2008), is essential for ligand-induced endocytosis (Janes et al., 2009) | SIGNOR-248426 |
P16144 | P42336 | 1 | binding | up-regulates | 0.417 | Stable expression of alpha6beta4 increased carcinoma invasion in a pi3k-dependent manner, and transient expression of a constitutively active pi3k increased invasion in the absence of alpha6beta4. Ligation of alpha6beta4 stimulated significantly more pi3k activity than ligation of beta1 integrins, establishing specific... | SIGNOR-54530 |
P78527 | Q92831 | 1 | phosphorylation | up-regulates activity | 0.417 | In response to UV-induced DNA damage, DNA-PK phosphorylates and activates PCAF, and activated PCAF is transferred to photo lesion sites and further acetylates RPA1 at K163. | SIGNOR-280092 |
Q13627 | P04637 | 1 | phosphorylation | up-regulates | 0.417 | Dyrk1a phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. we found that dyrk1a phosphorylates p53 at ser-15 in vitro and in immortalized rat embryonic hippocampal progenitor h19-7 cells. In addition, dyrk1a-induced p53 phosphorylation at ser-15 led to a robust induction of p53 target genes | SIGNOR-167407 |
Q01344 | Q06945 | 1 | binding | up-regulates activity | 0.417 | Sox4 activation by IL-5R_ appears to be direct, with syntenin functioning as an adaptor molecule. Syntenin mediates IL-5induced Sox4 activation. | SIGNOR-223010 |
P19338 | P10243 | 1 | binding | down-regulates activity | 0.417 | We identify nucleolin as one of the nuclear polypeptides that interact specifically with the A-Myb and c-Myb. We show that the interaction of nucleolin with Myb is functional because co-transfection of nucleolin down-regulates Myb transcriptional activity. | SIGNOR-221233 |
Q6DKK2 | Q9H444 | 1 | binding | up-regulates activity | 0.417 | We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. On t... | SIGNOR-265541 |
O75122 | P46940 | 1 | binding | up-regulates activity | 0.416 | IQGAP1 is a novel CLASP2-interacting protein| nonphosphorylated CLASP2 on microtubules is allowed to associate with IQGAP1 for the coupling of microtubules to actin filaments at the front of migrating cells. | SIGNOR-264828 |
Q96Q27 | O75369 | 1 | binding | down-regulates quantity by destabilization | 0.416 | Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteaso... | SIGNOR-271795 |
Q86UR5 | Q96E17 | 1 | relocalization | up-regulates activity | 0.416 | N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle | SIGNOR-264382 |
Q8N5S9 | Q8IU85 | 1 | phosphorylation | up-regulates activity | 0.416 | CaM-KIdelta exhibits Ca(2+)/CaM-dependent activity that is enhanced (approximately 30-fold) in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha, consistent with detection of CaM-KIdelta-activating activity in HeLa cells. | This sustained activation of CaM-KIdelta was completely abolished by Thr180Al... | SIGNOR-250715 |
P12931 | Q9Y6K9 | 1 | phosphorylation | down-regulates activity | 0.416 | Either IKKγ/NEMO WT or the Y374F mutant was coexpressed with each member of the Src family protein tyrosine kinases (SF-PTKs) in HEK 293T cells. Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKγ/NEMO undergoes phosphorylation upon TNF-α treatment or Kv... | SIGNOR-276370 |
P60510 | P53350 | 1 | dephosphorylation | down-regulates activity | 0.416 | PPP4C dephosphorylated PLK1 at the S137 site, negatively regulating its activity in the DSB response in early embryonic cells. | SIGNOR-277076 |
O15111 | Q9Y618 | 1 | phosphorylation | down-regulates | 0.416 | Nf-kappab transcription requires ikkalpha to phosphorylate smrt on chromatin, stimulating the exchange of corepressor for coactivator complexes. Ikk directly phosphorylates smrt to stimulate nuclear export. Ikkalpha orchestrates smrt derepression, a prerequisite for nf-kappab transcription and survival. | SIGNOR-129956 |
P21860 | O00329 | 1 | binding | up-regulates | 0.416 | Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. | SIGNOR-146867 |
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