IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P68400 | P55087 | 1 | phosphorylation | down-regulates activity | 0.416 | We found that the stress-induced kinase casein kinase (CK)II phosphorylates the Ser276 immediately preceding the tyrosine motif, increasing AQP4-mu 3A interaction and enhancing AQP4-lysosomal targeting and degradation. AQP4 phosphorylation by CKII may thus provide a mechanism that regulates AQP4 cell surface expression... | SIGNOR-250827 |
P52306 | P01116 | 1 | binding | up-regulates | 0.416 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171415 |
Q9UBS0 | P09651 | 1 | phosphorylation | up-regulates activity | 0.416 | Here, we show that S6K2 binds and phosphorylates hnRNPA1 on novel Ser4/6 sites, increasing its association with BCL-XL and XIAP mRNAs to promote their nuclear export. | SIGNOR-279569 |
P17252 | P41594 | 1 | phosphorylation | up-regulates activity | 0.416 | Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839. | SIGNOR-249278 |
Q9H1B7 | P01148 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.416 | EAP1 encoded a nuclear protein expressed in neurons involved in the inhibitory and facilitatory control of reproduction. EAP1 transactivated genes required for reproductive function, such as GNRH1, and repressed inhibitory genes, such as preproenkephalin. It contained a RING finger domain of the C3HC4 subclass required... | SIGNOR-267154 |
Q9UGU0 | P08254 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.416 | This result indicates that expression of SPBP is sufficient to transactivate a minimal promoter containing a single copy of the SPRE, as well as the full-length stromelysin promoter. | SIGNOR-266223 |
Q00987 | P27695 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.416 | Once the reaction proceeds beyond the monoubiquitination stage, MDM2 polyubiquitinates APE1 for degradation. | SIGNOR-278555 |
P19622 | P55075 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.416 | Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. | SIGNOR-265801 |
Q13627 | Q05193 | 1 | phosphorylation | down-regulates | 0.416 | Mnb/dyrk1a was shown to phosphorylate dynamin 1 and alter its interactions with several sh3 domain-containing endocytic accessory proteins.Phosphorylation At s795 and s857 was confirmed in full-length dynamin 1, and s857 was subsequently determined to be the major mnb/dyrk1a phosphorylation site in vitro. Phosphorylati... | SIGNOR-127440 |
Q14164 | O43734 | 1 | phosphorylation | up-regulates activity | 0.416 | IKKi was required for IL-17-induced phosphorylation of Act1 on Ser311, adjacent to a putative TRAF-binding motif. Substitution of the serine at position 311 with alanine impaired the IL-17-mediated Act1-TRAF2-TRAF5 interaction and gene expression. Thus, IKKi is a kinase newly identified as modulating IL-17 signaling th... | SIGNOR-262883 |
P60484 | Q13882 | 1 | dephosphorylation | down-regulates activity | 0.416 | PTEN inhibits PTK6 activity and downstream signaling in prostate cancer cells.|Using an in vitro phosphatase assay, we observed that PTEN was able to dephosphorylate PTK6 at tyrosine residue 342 in a dose dependent manner. | SIGNOR-276975 |
Q6ZUJ8 | P42336 | 1 | binding | up-regulates | 0.416 | This accumulation of tyrosine-phosphorylated bcap at the membrane with its associated pi3k would then allow for the catalysis of ptd ins p2 to ptd ins p3 and downstream pi3k-dependent signals. Therefore, bcap is an essential activator of the pi3k pathway downstream of tlr signaling, providing a brake to limit potential... | SIGNOR-191664 |
O00206 | Q16539 | 1 | phosphorylation | up-regulates activity | 0.416 | Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. | SIGNOR-263652 |
P10826 | P10827 | 2 | binding | up-regulates | 0.416 | We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs | SIGNOR-133234 |
O15409 | P08581 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.416 | FOXP2 binds directly to the 5' regulatory region of MET, and overexpression of FOXP2 results in transcriptional repression of MET. The expression of MET in restricted human neocortical regions, and its regulation in part by FOXP2, is consistent with genetic evidence for MET contributing to ASD risk. | SIGNOR-269054 |
P10827 | P10826 | 2 | binding | up-regulates | 0.416 | Ee report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs | SIGNOR-133243 |
P62837 | P50542 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.416 | Here we report on the identification of the protein-ubiquitin ligases that are responsible for the ubiquitination of the peroxisomal protein import receptor Pex5. It is demonstrated that each of the three RING peroxins Pex2, Pex10, and Pex12 exhibits ubiquitin-protein isopeptide ligase activity. Our results show that P... | SIGNOR-253023 |
Q13177 | P00519 | 1 | phosphorylation | down-regulates | 0.415 | The interaction of c-abl with the abl interactor protein abi2 is shown to be negatively regulated by phosphorylation of serines 637 and 638. These serines are adjacent to the pxxp motif (ptppkrs637s638sfr) that binds the sh3 domain of abi. phosphorylation of c-abl by pak2 inhibits the interaction between the sh3 domain... | SIGNOR-160215 |
Q8N1N5 | Q13153 | 1 | binding | up-regulates | 0.415 | We further found that cripak interacted with pak1 through the n-terminal regulatory domain and inhibited pak1 kinase in both in vitro and in vivo assays. | SIGNOR-141467 |
Q9H1C0 | P63096 | 1 | binding | up-regulates activity | 0.415 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256718 |
O76064 | Q9NS91 | 1 | binding | up-regulates | 0.415 | Rnf8 depletion also significantly reduced the accumulation of rad18 to chromatin fraction after ir | SIGNOR-185593 |
P01106 | O75592 | 2 | transcriptional regulation | down-regulates quantity by repression | 0.415 | We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn r... | SIGNOR-267145 |
P00519 | O00213 | 1 | phosphorylation | up-regulates | 0.415 | The c-abl tyrosine kinase phosphorylates the fe65 adaptor protein to stimulate fe65/amyloid precursor protein nuclear signaling. Here, we show that active c-abl stimulates app/fe65-mediated gene transcription and that this effect is mediated by phosphorylation of fe65 on tyrosine 547 within its second ptb domain. | SIGNOR-123476 |
P53350 | Q3KR16 | 1 | phosphorylation | up-regulates | 0.415 | We reported previously that a guanine nucleotide exchange factor, myogef, localizes to the central spindle, activates rhoa, and is required for cytokinesis. In this study, we have found that plk1 (polo-like kinase 1) can phosphorylate myogef, thereby recruiting myogef to the central spindle as well as enhancing myogef ... | SIGNOR-179954 |
Q6GPH4 | Q13490 | 1 | binding | down-regulates | 0.415 | Immunoprecipitation studies indicate that xaf1 binds to xiap,birc2,birc3. | SIGNOR-156843 |
P29350 | P00533 | 1 | dephosphorylation | down-regulates | 0.415 | The sh2-domain ptpase shp-1 binds to and dephosphorylates autophosphorylated egfr and may participate in modulation of egfr signaling in epithelial cells. Reduced shp-1 binding to the egfr y1173f mutant resulted in a reduced receptor dephosphorylation by coexpressed shp-1 and less interference with egf-dependent mitoge... | SIGNOR-59965 |
O00141 | Q96J92 | 1 | phosphorylation | up-regulates activity | 0.415 | In addition, we identified a novel SGK1 phosphorylation site (S1201) in WNK4, and phosphorylation at this site is reduced by Ca(2+)/CaM. | SIGNOR-276421 |
P00533 | Q8IVM0 | 1 | phosphorylation | down-regulates activity | 0.415 | We also detected tyrosine phosphorylation of Ymer by EGF stimulation as previously reported (Fig. 1A). Furthermore, we verified that EGF receptor-mediated tyrosine phosphorylation of Ymer is inhibited by AG1478, which is known as an EGF receptor tyrosine kinase inhibitor (Fig. 1B). A luciferase reporter assay showed ... | SIGNOR-262851 |
P12931 | Q92974 | 1 | phosphorylation | up-regulates activity | 0.415 | Src activates GEF-H1. | SIGNOR-277478 |
Q99933 | P10415 | 1 | binding | up-regulates activity | 0.415 | Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity| | SIGNOR-254118 |
Q00987 | Q8N6T7 | 1 | ubiquitination | down-regulates quantity | 0.415 | These results suggest that MDM2 degrades SIRT6 in a proteasome dependent manner.|USP10 has been shown to deubiquitinate and stabilize p53, a well-known substrate of MDM2, suggesting a mechanism whereby SIRT6 is ubiquitinated and destabilized by MDM2, which could be reversed by USP10 mediated deubiquitination. | SIGNOR-278702 |
Q7KZI7 | Q9NQT8 | 1 | phosphorylation | down-regulates activity | 0.415 | We report here the identification of GAKIN/KIF13B as a novel in vivo substrate for Par1b and present evidence that GAKIN/KIF13B plays a critical role in axon formation in neurons, which is negatively regulated by Par1b-mediated phosphorylation. Par1b phosphorylates GAKIN/KIF13B at both Ser1381 and Ser1410. | SIGNOR-262956 |
Q13464 | Q14457 | 1 | phosphorylation | up-regulates activity | 0.415 | Beclin1 is phosphorylated by ROCK1 at T119. | SIGNOR-278198 |
Q16665 | Q9Y4C1 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.415 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271568 |
P04150 | O43524 | 1 | transcriptional regulation | up-regulates quantity | 0.415 | We show that FOXO3 is an immediate early glucocorticoid receptor (GR) target, whose transcription is even further enhanced by conditions that mimic metabolic stress. | SIGNOR-255759 |
Q00535 | Q14814 | 1 | phosphorylation | down-regulates activity | 0.415 | In this case, cdk5 phosphorylates MEF2D on Ser444 suppressing its transcriptional activity. | SIGNOR-279509 |
P27361 | Q05469 | 1 | phosphorylation | up-regulates activity | 0.415 | Thus, activation of the ERK pathway appears to be able to regulate adipocyte lipolysis by phosphorylating HSL on Ser(600) and increasing the activity of HSL. | SIGNOR-249470 |
P05129 | P41594 | 1 | phosphorylation | up-regulates activity | 0.415 | Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839. | SIGNOR-249289 |
P04629 | P35222 | 1 | phosphorylation | up-regulates activity | 0.415 | EGFR and TRKA effect on WNT3a mediated Topflash induction was abolished by U0126 or expression of dominant negative LRP6-5A mutant (XREF_FIG), demonstrating that both EGFR and TRKA signal via ERK and LRP6 pathway to upregulate WNT and beta-catenin signaling.|FGFR2, FGFR3, EGFR and TRKA Phosphorylate \u03b2-catenin at T... | SIGNOR-279240 |
P53350 | Q8NFH5 | 1 | phosphorylation | down-regulates activity | 0.415 | Collectively, these data show that mitotic hyperphosphorylation of Nup53 by CDK1 and PLK1 contributes to its removal from NPCs.|The combined mutation of the CDK1 and PLK1 sites to phosphomimetic residues almost completely abolished NPC integration of Nup53, indicating that hyperphosphorylation of Nup53 might be incompa... | SIGNOR-279252 |
P00533 | O15492 | 1 | phosphorylation | up-regulates | 0.415 | Phosphorylation on tyr(168) was mediated by the epidermal growth factor receptor (egfr). We show here that endogenous rgs16 is phosphorylated after epidermal growth factor stimulation of mcf-7 cells. | SIGNOR-98267 |
O00141 | P43003 | 1 | phosphorylation | up-regulates activity | 0.415 | Site‐directed mutagenesis of the SGK1 phosphorylation sites in the Nedd4‐2 protein (S382A,S468ANedd4‐2) and in the EAAT1 protein (T482AEAAT1, T482DEAAT1) significantly blunts the effect of S422DSGK1. Introduction of a negative charge at the SGK phosphorylation site in the EAAT1 protein leads to a strong stimulation of ... | SIGNOR-263075 |
Q9H1H9 | Q68DK2 | 1 | binding | up-regulates activity | 0.415 | We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. On t... | SIGNOR-265539 |
Q16539 | Q9HBH9 | 1 | phosphorylation | up-regulates | 0.415 | Erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity | SIGNOR-48349 |
Q00535 | Q13315 | 1 | phosphorylation | up-regulates | 0.415 | Here we show that cdk5 (cyclin-dependent kinase 5), activated by dna damage, directly phosphorylates atm at ser 794 in post-mitotic neurons. Phosphorylation at ser 794 precedes, and is required for, atm autophosphorylation at ser 1981, and activates atm kinase activity | SIGNOR-183454 |
P07900 | P36897 | 1 | binding | up-regulates | 0.415 | The data in fig. 5 suggest that hsp90 specifically interacts with t?RI And t?RII In vitro and in vivo. Coupled with our data showing that loss of hsp90 function decreases t?R Levels and blocks tgf?-Induced smad2/3 activation and transcription, this result suggests that hsp90 controls tgf? Signaling as an essential comp... | SIGNOR-179268 |
O75592 | P01106 | 2 | ubiquitination | down-regulates quantity by destabilization | 0.415 | We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn r... | SIGNOR-267147 |
O95644 | P05231 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.415 | The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in hum... | SIGNOR-251730 |
P31749 | Q15942 | 1 | phosphorylation | down-regulates | 0.415 | Akt binds and phosphorylates zyxin on serine 142, leading to its association with acinus zyxin is a substrate of caspases, but akt phosphorylation fails to protect its proteolytic degradation | SIGNOR-156122 |
Q13535 | Q9Y253 | 1 | phosphorylation | up-regulates | 0.415 | Atr-mediated phosphorylation of dna polymerase _ is needed for efficient recovery from uv damage. We show that, after uv irradiation, pol_ becomes phosphorylated at ser601 by the ataxia-telangiectasia mutated and rad3-related (atr) kinase. Atr-dependent phosphorylation of pol_ is necessary to restore normal survival an... | SIGNOR-171290 |
Q15466 | P10275 | 1 | binding | down-regulates | 0.415 | We demonstrated that shp inhibited both ar-lbd and ntd-dependent transactivation, which evidenced for the first time a protein capable of inhibiting a steroid receptor amino-terminal-dependent transactivation. We further characterized the shp mechanism of action by showing that shp reversed ar coactivator-mediated acti... | SIGNOR-112589 |
Q8IYA7 | Q7RTU7 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.415 | MKX is a meniscus-enriched transcription factor. In human meniscus cells, MKX regulates the expression of meniscus marker genes, OA-related genes, and other transcription factors, including Scleraxis (SCX), SRY Box 5 (SOX5), and Runt domain-related transcription factor 2 (RUNX2). | SIGNOR-267213 |
Q9P1W9 | Q13541 | 1 | phosphorylation | up-regulates activity | 0.414 | Further, PIM2 triggered phosphorylation of AKT and 4EBP1 (XREF_FIG) clearly demonstrating the activation of PI3K pathway. | SIGNOR-279091 |
Q16539 | Q99626 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.414 | ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation | SIGNOR-250092 |
Q92993 | P46531 | 1 | acetylation | down-regulates | 0.414 | This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60. | SIGNOR-156923 |
P12931 | Q9UJM3 | 1 | phosphorylation | down-regulates activity | 0.414 | Prior phosphorylation of Y395 dramatically increases the rate of EGFR phosphorylation of Mig6 on Y394 in vitro, and suppression of Src activity pharmacologically or by shRNA decreased phosphorylation of Mig6 on this site in cells, impairing EGFR binding and inhibition.|We further found that Mig6 inhibition of EGFR is m... | SIGNOR-279116 |
Q6K0P9 | Q00987 | 1 | binding | down-regulates quantity by destabilization | 0.414 | Here, we show that IFIXalpha1 downregulates HDM2, a principal negative regulator of p53, at the posttranslational level. IFIXalpha1 destabilizes HDM2 protein and promotes its ubiquitination. The E3 ligase activity of HDM2 appears to be required for this IFIXalpha1 effect. Importantly, HDM2 downregulation is required fo... | SIGNOR-268493 |
Q13464 | Q9NRY4 | 1 | phosphorylation | down-regulates activity | 0.414 | these results indicate that Rho-kinase can phosphorylate p190A RhoGAP at Ser1150 in COS7 cells. Similarly, the immunoblot analysis, through the use of the anti-p190A RhoGAP-pT1226 and -pS1236 antibodies, revealed that Rho-kinase can phosphorylate p190A RhoGAP at Thr1226 and Ser1236 in COS7 cells | SIGNOR-276177 |
P00519 | P29350 | 1 | phosphorylation | up-regulates activity | 0.414 | The results demonstrate that the SH3 domain of ABL1 interacts with a WPDHGVPSEP motif (residues 417-426) in the catalytic domain of SHPTP1 and that ABL1 phosphorylates C terminal Y536 and Y564 sites. | SIGNOR-260820 |
O15264 | P16949 | 1 | phosphorylation | down-regulates | 0.414 | Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. | SIGNOR-36362 |
Q13239 | P29317 | 1 | binding | down-regulates quantity by destabilization | 0.414 | These data are consistent with a model where SLAP induces Ephrin-independent EPHA2 degradation. | This activity is independent from CBL but requires SLAP SH3 interaction with the ubiquitination factor UBE4A and SLAP SH2 interaction with pTyr594-EPHA2. | SIGNOR-262964 |
P06241 | O14522 | 1 | phosphorylation | down-regulates activity | 0.414 | Synapse formation by PTPRT was inhibited by phosphorylation of tyrosine 912 within the membrane-proximal catalytic domain of PTPRT by Fyn. This tyrosine phosphorylation reduced phosphatase activity of PTPRT | SIGNOR-275543 |
P19784 | Q9UNN4 | 1 | phosphorylation | up-regulates activity | 0.414 | ALF was able to stabilize the binding of TBP to DNA, but it could not stabilize TBP mutants A184E, N189E, E191R, and R205E nor could it facilitate binding of the TBP-like factor TRF2/TLF to a consensus TATA element. However, phosphorylation of ALF with casein kinase II resulted in the partial restoration of complex for... | SIGNOR-250993 |
Q8N5S9 | Q14012 | 1 | phosphorylation | up-regulates activity | 0.414 | Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. | SIGNOR-250717 |
P51812 | P19634 | 1 | phosphorylation | up-regulates activity | 0.414 | In pressured arteries, RSK2 dependent activation of NHE-1 was associated with increased intracellular Ca 2+ transients, which would be expected to increase MLCK activity, thereby contributing to basal tone and myogenic responses.|Together, these data indicate that Ser 703 in NHE-1 is phosphorylated by RSK2, that RSK2 i... | SIGNOR-280119 |
O14757 | Q9Y294 | 1 | phosphorylation | up-regulates activity | 0.414 | Chk1 activated by ataxia telangiectasia mutated (ATM) kinase on DNA breaks in G1 promotes NHEJ through direct phosphorylation of ASF1A at Ser-166. ASF1A phosphorylated at Ser-166 interacts with the repair protein MDC1 and thus enhances MDC1's interaction with ATM and the stable localization of ATM at DNA breaks. | SIGNOR-277620 |
P12931 | Q9NZQ3 | 1 | phosphorylation | up-regulates activity | 0.414 | These results indicate that phosphorylation of SPIN90 by Src is essential for its synaptic targeting. | SIGNOR-279387 |
O43561 | P42336 | 1 | binding | up-regulates activity | 0.414 | By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) a... | SIGNOR-246065 |
P52306 | P61224 | 1 | binding | up-regulates | 0.414 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171552 |
Q9Y2U5 | Q02750 | 1 | phosphorylation | up-regulates | 0.414 | Both mekk2 and mekk3 are able to activate the jun kinase pathway in vivo. However, following routine immunoprecipitation in triton x-100, mekk2 but not mekk3 is able to effectively phosphorylate both sek-1 and mek-1 and to undergo autophosphorylation | SIGNOR-107692 |
P17612 | Q13224 | 1 | phosphorylation | up-regulates activity | 0.414 | Here we identify serine residue 1166 (Ser1166) in the carboxy-terminal tail of the NMDAR subunit GluN2B to be a direct molecular and functional target of PKA phosphorylation critical to NMDAR-dependent Ca(2+) permeation and Ca(2+) signaling in spines. | SIGNOR-276616 |
Q7Z2W4 | O95453 | 1 | binding | up-regulates activity | 0.414 | We provide evidence indicating that ZAP selectively recruits cellular poly(A)-specific ribonuclease (PARN) to shorten the poly(A) tail of target viral mRNA and recruits the RNA exosome to degrade the RNA body from the 3′ end. | SIGNOR-261296 |
P31751 | Q9GZV1 | 1 | phosphorylation | up-regulates | 0.414 | In vitro and in vivo studies confirmed that akt phosphorylates ankrd2 at ser-99. moreover, the forced expression of a phosphorylation-defective mutant form of ankrd2 in c2c12 myoblasts promoted a faster differentiation program, implicating akt-dependent phosphorylation at ser-99 in the negative regulation of myogenesi... | SIGNOR-236978 |
P42574 | Q4V328 | 1 | cleavage | up-regulates activity | 0.414 | These results suggest that the region of GRASP‐1 downstream of the Caspase‐3‐cleavage site is capable of activating the JNK signaling pathway by enhancing the phosphorylation of JNK. these results suggest that full length GRASP‐1 does not enhance JNK pathway activity, possibly due to the inhibitory effect of the N‐term... | SIGNOR-260641 |
Q9Y243 | O15111 | 1 | phosphorylation | up-regulates | 0.414 | Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosph... | SIGNOR-187062 |
O00254 | P30679 | 1 | binding | up-regulates activity | 0.414 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257360 |
Q7L7X3 | Q7KZI7 | 1 | phosphorylation | up-regulates activity | 0.414 | MARK family kinases can be activated by phosphorylation of a conserved threonine (Thr-208 in MARK2), and inactivated by phosphorylation of a serine (Ser-212), both in the activation loop of the catalytic domain. Activation is achieved by the kinases MARKK/TAO1 or LKB1, although the inactivating kinase was unknown. We s... | SIGNOR-276164 |
Q8TDV5 | P63092 | 1 | binding | up-regulates activity | 0.414 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256768 |
Q5XUX0 | P24385 | 1 | binding | down-regulates quantity by destabilization | 0.413 | FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2. | SIGNOR-277379 |
O75116 | Q96A00 | 1 | phosphorylation | up-regulates activity | 0.413 | A major kinase for GPCR‐induced CPI‐17 phosphorylation is PKC which is activated by the PLCbeta‐produced signaling messenger diacylglycerol (DAG). It phosphorylates CPI‐17 at Thr38 residue that directly docks at the active site of MLCP, thereby inhibiting its activity and promoting an increase of phosphorylation of myo... | SIGNOR-96696 |
Q5S007 | P30048 | 1 | phosphorylation | down-regulates activity | 0.413 | Here, we show that LRRK2 interacts with human peroxiredoxin 3 (PRDX3), a mitochondrial member of the antioxidant family of thioredoxin (Trx) peroxidases. Importantly, mutations in the LRRK2 kinase domain significantly increased phosphorylation of PRDX3 compared to wild-type. The increase in PRDX3 phosphorylation was as... | SIGNOR-262891 |
Q92630 | Q9UHD2 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.413 | We further found that DYRK2 phosphorylated Ser527 of TBK1, which is essential for the recruitment of NLRP4 and for the E3 ubiquitin ligase DTX4 to degrade TBK1. | SIGNOR-276939 |
P25105 | O95837 | 1 | binding | up-regulates activity | 0.413 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257436 |
Q96J02 | Q16621 | 1 | ubiquitination | down-regulates activity | 0.413 | Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination| Interestingly, Itch suppressed the transactivation activity of p45/NF-E2 by adding a Lys63-linked polyubiquitin chain. Confocal microscopy revealed that ubiquitinated p45/NF-E2 became localized in the cytoplasm when Itch was over-expressed. Thus, Itch-med... | SIGNOR-275553 |
P17252 | P35222 | 1 | phosphorylation | down-regulates | 0.413 | As shown in Fig. 1 B, PKCalpha readily phosphorylated Ser33 and Ser37 / Thr41 on full-length beta-catenin (beta-catenin 1 - 781) and CTD deletion mutant (beta-catenin 1-682).|To examine the effect of the armadillo repeats 1-5 on PKCalpha mediated beta-catenin degradation, DNA constructs expressing beta-catenin 1 - 781 ... | SIGNOR-278492 |
P49354 | P01112 | 1 | null | up-regulates activity | 0.413 | Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. | SIGNOR-242568 |
Q96RR4 | Q14012 | 1 | phosphorylation | up-regulates activity | 0.413 | Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. | SIGNOR-250716 |
Q92769 | P33076 | 1 | deacetylation | down-regulates quantity by repression | 0.413 | We report that CIITA and histone deacetylase 2 (HDAC2) interact in smooth muscle cells and macrophages as assayed by co-immunoprecipitations. HDAC2 deacetylates CIITA whereas both the HDAC inhibitor trichostatin A (TSA) and over-expression of HDAC2 interfering RNA increase CIITA acetylation. HDAC2 down-regulates CIITA ... | SIGNOR-254231 |
Q13547 | P36952 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.413 | We found that maspin is selectively upregulated in IFIXα-expressing cells and involved in anti-invasive activity of IFIXα. We also present evidence indicating that IFIXα downregulates histone deacetylase 1 (HDAC1), which is possibly involved in the silencing of the maspin gene in human breast cancer cells. To confirm t... | SIGNOR-268494 |
P43378 | P46459 | 1 | dephosphorylation | down-regulates | 0.413 | Our results suggest that the molecular mechanism by which ptp-meg2 promotes secretory vesicle fusion involves the local release of nsf from a tyrosine-phosphorylated, inactive state. | SIGNOR-128348 |
P46100 | O96006 | 1 | binding | up-regulates activity | 0.413 | XNP/dATRX physically interacts with DREF. our results show that DREF is required for the proper expression of pnr and that XNP/dATRX binds to DREF at the DRE sites, resulting in the repression of pnr gene expression. | SIGNOR-239729 |
P28482 | P19484 | 1 | phosphorylation | down-regulates activity | 0.413 | Evidence for ERK2-mediated TFEB phosphorylation came from ERK2-TFEB coimmuno-precipitation (fig. S12C) in normal but not in starved medium and from a peptide-based kinase assay showing that mutation of Ser142 to alanine abolished ERK2-mediated phosphorylation ( | SIGNOR-248279 |
P50613 | P03372 | 1 | phosphorylation | up-regulates | 0.413 | Activation of estrogen receptor alpha by s118 phosphorylation involves a ligand-dependent interaction with tfiih and participation of cdk7. | SIGNOR-81170 |
P36873 | P05198 | 1 | dephosphorylation | up-regulates activity | 0.412 | Dephosphorylation of eIF2α is central to ISR signal termination to restore protein synthesis and normal cell functioning. It is mediated by protein phosphatase 1 (PP1) complex that recruits a PP1 catalytic subunit (PP1c) and one of the two regulatory subunits. In mammals, phosphatase activity is regulated by either PP... | SIGNOR-254119 |
O75665 | Q13099 | 1 | binding | up-regulates activity | 0.412 | Ofd1 acts at the distal centriole to build distal appendages, recruit Ift88, and stabilize centriolar microtubules at a defined length. | SIGNOR-251973 |
P37802 | P60709 | 1 | binding | down-regulates activity | 0.412 | Taken together, our data propose a novel, oncogene-tumor suppressor interplay, where oncogenic PFTK1 confers HCC cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 via phosphorylation. | SIGNOR-265104 |
O94952 | Q9Y6B2 | 1 | binding | down-regulates quantity by destabilization | 0.412 | SCFFBXO21 ubiquitylates and thereby targets EID1 for degradation.We have now applied this approach to an uncharacterized human F-box protein, FBXO21, which serves as the substrate-recognition subunit of a SKP1-CUL1-F-box protein (SCF)-type E3, thereby identifying EID1 (EP300-interacting inhibitor of differentiation 1) ... | SIGNOR-272429 |
P24385 | O15379 | 1 | binding | up-regulates | 0.412 | Collectively, these studies suggest an important role of cyclin d1 in regulation of ppargamma-mediated adipocyte differentiation through recruitment of hdacs to regulate ppar response element local chromatin structure and ppargamma function. | SIGNOR-134056 |
P28482 | P10828 | 1 | phosphorylation | down-regulates activity | 0.412 | We concluded that serine 142 of the tr dbd is the likely site of phosphorylation by t(4)-activated mapk and that the docking site on tr for activated mapk includes residues 128-133 (kgffrr), a basic amino acid-enriched motif novel for mapk substrates. Tr mutations in the proposed mapk docking domain and at residue 142 ... | SIGNOR-102216 |
P54829 | P42262 | 1 | dephosphorylation | down-regulates activity | 0.412 | One study showed that stimulation of the metabotrophic glutamate receptor mGluR5 leads to a STEP mediated tyrosine dephosphorylation of GluA2 and internalization of GluA1 and GluA2, although the tyrosine residue on GluA2 that is dephosphorylated by STEP remains unidentified. | SIGNOR-277040 |
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