Datasets:
H2KP
/
cdip-annotations-formnet-v1

Dataset card Data Studio Files
xet
Community
id
stringlengths
18
46
words
list
bboxes
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2062179394.layout.json
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2071863501c.layout.json
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91891329.layout.json
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2026454850.layout.json
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2031536180_2031536183-3.layout.json
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2057719273.layout.json
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ton04812.92_ton04812.97-3.layout.json
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11300117-0136-5.layout.json
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ti30859716.layout.json
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2063597106_2063597113-4.layout.json
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2505531228_1235-0.layout.json
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"disposed", "to", "self-administer", "a", "drug", "as", "a", "function", "of", "the", "time", "since", "the", "last", "drug", "administration,", "Weeks", "(30)", "conditioned", "rats", "to", "press", "a", "lever", "for", "3.2", "or", "10", "mg/kg", "of", "morphine", "intravenously.", "During", "a", "3-he", "abstinence", "period", "the", "hourly", "rate", "increased", "from", "a", "mean", "of", "321", "at", "3.2", "mg/kg", "and", "1.56", "at", "10", "mg/kg", "to", "21.83.", "Using", "a", "far", "Tonger", "deprivation", "period,", "Davis", "&", "Nichols", "(92)", "found", "that", "rats", "immediately", "placed", "in", "an", "oral", "preference", "situation", "following", "a", "period", "of", "morphine", "treatment", "ingested", "larger", "quantities", "of", "marphine", "than", "animals", "which", "were", "deprived", "of", "morphine", "for", "4", "days", "before", "being", "placed", "in", "the", "oral", "preference", "situation.", "Thompson", "&", "Schuster", "(39)", "trained", "monkeys", "to", "self-", "administer", "morphine", "intravenousty", "(1", "mg/kg", "Q.1D.)", "and", "then", "deprived", "the", "animals", "of", "the", "opportunity", "to", "self-administer", "for", "24", "hr.", "Using", "a", "chained", "(g", "chedule", "of", "marphine", "reinforcement", "it", "was", "faund", "that", "rates", "inercased", "ap-", "&", "proximately", "tenfold", "during", "the", "fixed-interval", "component,", "and", "the", "length", "of", "<", "time", "to", "complete", "25", "responscs", "on", "a", "fixed-ratio", "schedule", "decreased", "as", "well.", "Rats", "previously", "made", "physically", "dependent", "on", "morphine", "were", "deprived", "of", "the", "drug", "7,", "7", "to", "24,", "or", "24", "ta", "48", "hr", "and", "tested", "for", "preference", "between", "tap", "015600y", "SELF", "ADMINISTRATION", "DF", "DRUGS", "495", "water", "and", "the", "synthetic", "opioid,", "etonitazine", "{Wikler", "et", "al.", "(11)].", "The", "quantity", "of", "etonitazine", "cansumed", "varied", "directly", "with", "the", "number", "of", "hours", "of", "morphine", "deprivation,", "Thus,", "while", "physical", "dependence", "is", "not", "a", "neces-", "sary", "antecedent", "condition", "for", "drugs", "to", "act", "as", "reinforcers,", "the", "reinforcing", "efficacy", "of", "a", "drug", "is", "amplified", "during", "withdrawal", "in", "physicalty-dependent", "or-", "ganisms,", "Current", "environmenial", "circumstances—Envirenmental", "conditions", "are", "clearly", "important", "determinants", "of", "the", "effectiveness", "of", "any", "reinforcer,", "and", "we", "have", "no", "reason", "to", "suspect", "drug-reinforced", "behavior", "is", "any", "different,", "Among", "the", "first", "demonstrations", "of", "the", "importance", "of", "environmental", "condi-", "tions", "in", "drug", "self.administration", "was", "Masserman", "&", "Yum's", "(4)", "study", "of", "al-", "cohol", "ingestion", "under", "“conflict”", "contingencies.", "Cats", "were", "presented", "with", "a", "blast", "of", "air", "as", "they", "approached", "a", "food", "dish.", "The", "animals,", "in", "addition", "to", "avoiding", "the", "food", "dish,", "showed", "a", "number", "of", "behavioral", "changes", "judged", "to", "be", "“neurotic.”", "Cats", "given", "1", "g/kg", "of", "alcohol", "during", "training", "did", "not", "develop", "these", "reactions", "and", "administration", "of", "this", "dosage", "of", "alcohol", "to", "a", "“neurotic”", "cat", "diminished", "its", "“phobic", "aversion.\"", "These", "enimals", "subsequently", "showed", "a", "preference", "for", "food", "or", "milk", "which", "contained", "alcohol.", "Clark", "&", "Polish", "(93)", "reported", "that", "the", "consumption", "of", "ethyl", "alcohol", "hy", "Rhesus", "monkeys", "increased", "when", "these", "animals", "were", "placed", "on", "a", "shock-", "avoidance", "schedule,", "Subsequent", "work", "by", "Mello", "&", "Mendelson", "(94)", "demon-", "strated", "that", "shock-avoidance", "schedules", "elicited", "an", "abrupt", "increase", "in", "alcchol", "consumption", "in", "a", "mankey", "which", "freely", "selected", "alcoho!", "prior", "to", "condition-", "ing.", "The", "avoidance", "schedule", "had", "no", "demonstrable", "effect", "on", "alcohol", "con-", "sumption", "for", "a", "monkey", "that", "had", "previously", "refused", "alcohol", "in", "a", "free", "choice", "situation.", "The", "inereased", "alcohol", "consumption", "associated", "with", "the", "avoidance", "schedule", "continued", "for", "6", "weeks", "following", "the", "termination", "of", "aveidance", "con-", "ditioning.", "The", "level", "of", "alcohal", "intake", "associated", "with", "the", "avoidance", "sched-", "ule,", "however,", "did", "not", "differ", "significantly", "from", "levels", "achieved", "by", "control", "monkeys", "after", "4", "to", "7", "months", "in", "a", "free-choice", "situation.", "Thus,", "the", "avoidance", "conditioning", "proditced", "a", "more", "rapid", "inicrease", "in", "alcohol", "consumption", "but", "not", "a", "significantly", "greater", "level", "of", "consumption.", "Of", "interest", "is", "the", "fact", "that", "none", "of", "the", "monkeys", "showed", "any", "withdrawal", "signs", "when", "drug", "availability", "was", "abruptly", "terminated.", "Davis", "&", "Miller", "(44)", "presented", "rats", "with", "painful", "footshock", "on", "an", "inter-", "mittent", "schedule", "and", "observed", "the", "frequency", "of", "lever", "pressing", "which", "pro-", "duced", "intravenous", "infusions", "of", "amobarbital", "(1.5", "mg/kg).", "Paired", "anituals", "were", "also", "provided", "with", "the", "opportunity", "to", "self-administer", "amobarbital", "but", "rteceived", "no", "shocks.", "Over", "the", "first", "three", "daily", "tests,", "shocked", "rats", "self-admin-", "istered", "amobarbital", "while", "controfs", "did", "net.", "In", "a", "later", "study,", "Davis,", "Lulenski", "&", "Miller", "(45)", "replicated", "this", "effect,", "and", "in", "addition", "found", "hexobarbital", "would", "be", "self-administered", "under", "the", "same", "conditions.", "Whether", "these", "bar-", "hiturates", "are", "effective", "reinforcers", "in", "the", "rat", "only", "under", "conditions", "of", "fear", "or", "pain,", "must", "wait", "for", "a", "demonstration", "that", "a", "nonaversive", "stimulus", "pre-", "sented", "on", "the", "same", "schedule", "is", "ineffective.", "Further,", "as", "previously", "stated,", "De-", "neau,", "Yanagita", "&", "Seevers", "(52)", "have", "shown", "that", "barbiturates", "are", "effective" ]
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0013141051.layout.json
[ "MEMORANDUM", "TO:", "MR.", "E.", "PEPPLES", "CC:", "Mr.", "J.", "W.", "Groome", "Mr.", "L,", "A,", "Pizer", "—", "Mr.", "L,", "R.", "Lewis", "Mr.", "W,", "A,", "Land", "FROM:", "CARTER", "BROACH", "DATE:", "January", "29,", "1975", "SUBJECT:", "VICEROY", "Attached", "for", "your", "review", "is", "the", "VICEROY", "\"TWO", "PACKS", "FREE'\"", "Offer", "Carton", "Copy.", "May", "we", "have", "your", "response", "concerning", "this", "copy.", "C.", "B.", "CB/lg", "attachment", "8204TV0S9" ]
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524860047+-0116-39.layout.json
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2065298710_8719-8.layout.json
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508939370_508939517-64.layout.json
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0060132598-9.layout.json
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511781859_511781868-3.layout.json
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502636262_502636273-10.layout.json
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500692166_500692218-6.layout.json
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2046807567_7643-22.layout.json
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2020226017_6019-0.layout.json
[ "To:", "PHILIP", "MORRIS", "U.", "S.", "A.", "INTER-OFFICE", "CORRESPONDENCE", "Richmond,", "Virginia", "Dr.", "Ken", "Shafer", "Date:", "Decenber", "19,", "1991", "From:", "R,", "W.", "Dwyer", "Subject:", "Annual", "Accomplishments", "of", "Project", "Tomorrow", "STRATEGY", "I.", "IGNITION", "TEST", "DEVELOPMENT", "1.", "Seven", "cigarette", "designs", "were", "fabricated", "for", "the", "seven", "laboratories", "participating", "in", "the", "CORESTA-III", "ignition-propensity", "tests.", "The", "cigarettes", "were", "fabricated", "in", "Semiworks,", "tested", "by", "CTSD,", "canned,", "and", "shipped", "to", "the", "participants.", "The", "cigaretites", "were", "tested", "in-house", "for", "iignition", "propensity", "as", "part", "of", "the", "CORESTA-III", "tests.", "The", "industry-wide", "results", "of", "the", "CORESTA-III", "ignition", "tests", "were", "evaluated.", "These", "tests", "were", "generally", "discounted", "by", "the", "industry", "because", "of", "lab-to-lab", "variability.", "However,", "we", "found", "through", "careful", "analysis", "that", "ignitions", "were", "determined", "solely", "by", "the", "burn-promoter", "treatment", "level", "of", "the", "fabric", "and", "were", "independent", "of", "the", "cigarette", "properties.", "Furthermore,", "we", "discovered", "that", "the", "number", "of", "extinguishments", "is", "related", "to", "the", "cigarette", "properties", "and", "independent", "of", "the", "fabric", "treatment-level.", "The", "effects", "of", "draft", "rate", "on", "the", "ignition", "propensities", "of", "cigarettes", "on", "substrates", "were", "investigated.", "The", "air", "flow", "was", "directed", "through", "the", "fabric/foam", "substrate,", "along", "the", "substrate", "surface", "directed", "parallel", "to", "the", "cigarette,", "and", "along", "the", "surface", "perpendicular", "the", "the", "cigarette", "axis.", "Additionally,", "we", "investigated", "the", "effects", "of", "crevice", "and", "flat", "configurations", "on", "ignitien", "testing.", "A", "chamber", "has", "been", "designed,", "tested,", "and", "modified", "for", "larger-scale", "ignition-testing", "of", "cigarettes.", "This", "chamber", "is", "being", "used", "to", "evaluate", "sixteen", "cigarettes:", "simultaneously,", "rather", "than", "singly.", "STRATEGY", "II.", "IGNITION'", "MECHANISM", "STUDIES", "1.", "Ring", "calorimeters,", "heat", "flux", "gauges,", "and", "thermocouples", "imbedded", "in", "substrates", "have", "been", "constructed", "and", "used", "to", "measure", "the", "thermal", "properties", "of", "cigarettes", "smouldering", "freely", "and", "on", "substrates.", "The", "mass", "spectrometer", "was", "used", "to", "measure", "the", "oxygen", "concentrations", "at", "the", "cigarette/substrate", "interface.", "The", "mass", "burn", "rates", "of", "most", "PM", "products,", "as", "well", "as", "all", "TLA", "samples", "produced", "this", "year,", "have", "been", "monitored", "on", "a", "monthly", "basis", "in", "order", "to", "assess", "their", "manufacturing", "variabilities.", "The", "mass", "burn", "rates", "of", "all", "RJR", "brands", "were", "measured", "in", "order", "to", "determine", "if", "they", "are", "systematically", "reducing", "the", "burn", "rates", "of", "their", "products.", "The", "basis", "weights,", "chalk", "contents,", "and", "burn-promoter", "levels", "of", "the", "wrappers", "of", "all", "domestic", "cigarettes", "were", "measured", "in", "order", "to", "survey", "the", "wrapper", "properties", "of", "our", "competitors’", "products.", "The", "effects", "of", "high", "temperatures", "and", "high", "humidities", "on", "the", "mass", "burn", "rates", "and", "wrapper", "permeabilities", "of", "experimental", "cigarettes", "were", "determined.", "These", "measurements", "were", "made", "to", "see", "if", "the", "primary", "cigarette", "samples", "that", "NIST", "has", "stored", "for", "three", "years", "might", "have", "changed", "with", "time.", "IR-camera", "studies", "were", "performed", "on", "cigarettes", "smouldering", "on", "substrates.", "These", "results", "showed", "that", "the", "temperature", "of", "the", "substrate", "directly", "under", "the", "cigavette", "coal", "varies", "cyclically", "during", "the", "smoulder", "period.", "This", "4109220202" ]
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500603267+-3283-5.layout.json
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0001039501-63.layout.json
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501302256_501302323-55.layout.json
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1003099995.layout.json
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50517337-7342-2.layout.json
[ "1044", "A", "100", "(neay", "|", "3", ".?Z:", "so}", "t", "$", "}", "3", "y", ".", "o", "40", "s", "80", "100", "120", "1s0", "Time", "(days)", "ofter", "Transplant", "B", "S", "15", "£T", "5", "2", "g", "§", "10", "<", "}", "3", "5", "20", "40", "60", "8", "100", "120", "140", "Time", "(days)", "after", "Transplant", "FIGURE", "2.", "(A)", "The", "induction", "of", "syngeneic", "GVHD", "is", "not", "linked", "to", "MHC", "haplotype.", "BALB/c", "mice", "were", "irradiated,", "reconstituted", "with", "syngeneic", "marrow,", "and", "treated", "with", "CsA,", "15", "mg/kg/day", "for", "21", "days", "pg", "described", "in", "the", "Materials", "and", "Methods", "section,", "Percentage", "of", "surviva]", "was", "adjusted", "to", "100", "percent,", "which", "represents", "animals", "that", "were", "alive", "at", "day", "21", "after", "bone", "marrow", "transplantation.", "The", "numbers", "in", "parey-", "theses", "represent", "the", "number", "of", "animals", "in", "each", "treatment", "group,", "All", "the", "irradiation", "control", "animals", "(n=10)", "were", "dead", "by", "day", "15", "posttrayg-", "plant.", "(B)", "Weight", "profiles", "of", "BALB/c", "following", "syngeneic", "GVIiD", "induction", "protocol.", "Animals", "were", "weighed", "3", "times", "weekly", "following", "treatment,", "and", "the", "average", "weight", "for", "each", "group", "determined,", "T'e", "numbers", "in", "parentheses", "represent", "the", "number", "of", "animals", "weighed", "at", "each", "time", "point.", "The", "data", "presented", "are", "representative", "of", "2", "experimeitg", "in", "which", "BALB/c", "mice", "were", "transplanted.", "of", "organ", "involvement", "generally", "seen", "in", "acute", "GVHD,", "they", "did", "represent", "lesions", "associated", "with", "acute", "GVHD", "in", "the", "mouse", "g", "described", "by", "Rappaport", "et", "al.", "(22)", "and", "Seemayer", "et", "al.", "(23).", "A", "shown", "in", "Figure", "3,", "the", "large", "intestine", "showed", "progressive", "mucosal", "lesions,", "which", "had", "the", "appearance", "of", "an", "acute", "colitis", "(Fig.", "3B-D)", "compared", "to", "the", "normal", "appearance", "of", "contry]", "large", "intestine", "(Fig.", "3A).", "The", "earliest", "identifiable", "alteration", "was", "invasion", "of", "mucosal", "glands", "by", "acute", "inflammatory", "celly", "associated", "with", "epithelial", "cell", "necrosis", "and", "dropout", "(Fig.", "3R).", "Other", "animals", "showed", "prominent", "crypt", "abscess", "formation", "with", "confluent", "epithelial", "cell", "loss", "or", "complete", "gland", "loss", "(Fig.", "30),", "Crypt", "abscesses", "were", "prominent", "in", "all", "involved", "colons.", "Finally,", "TRAISPLANTATION", "Vol.", "48,", "No.", "6", "in", "some", "animals", "there", "was", "confluent", "gland", "loss", "culminating", "in", "a", "complete", "mucosal", "ulceration", "and", "replacement", "with", "granula-", "tion", "tissue", "(Fig.", "3D).", "These", "lesions", "were", "always", "focal,", "and", "at", "times", "they", "could", "be", "found", "adjacent", "to", "milder", "lesions", "or", "unin-", "volved", "mucosa.", "Changes", "typical", "of", "GVHD", "seen", "in", "the", "colon", "were", "not", "seen", "in", "the", "small", "intestine.", "Sections", "of", "thymus", "from", "animals", "in", "the", "syngeneic", "control", "group", "showed", "no", "pathologic", "lesions", "(Fig.", "44).", "Thymus", "sections", "from", "the", "CsA-treatment", "group", "were", "unidentifiable", "grossly", "and", "could", "only", "be", "located", "by", "sectioning", "complete", "neck", "blocks.", "Thymus", "remnants", "identified", "histologically", "showed", "complete", "atrophy", "of", "the", "cortex", "as", "well", "as", "loss", "of", "medullary", "epithelium", "and", "lymphoeytes", "(Fig.", "4B).", "Spleens", "from", "all", "animals", "in", "the", "CsA-treatment", "group", "showed", "significant", "atrophy", "when", "compared", "to", "the", "size", "of", "spleens", "from", "control", "animals.", "Sections", "of", "spleens", "from", "the", "diluent", "control", "group", "showed", "intact", "white", "pulp", "and", "red", "pulp", "with", "active", "he-", "matopoiesis", "(Fig.", "5A).", "In", "histologic", "sections", "of", "the", "treatment", "group", "spleens,", "the", "white-pulp-red-pulp", "demarcation", "was", "ob-", "scured", "by", "a", "lymphoblastoid", "infiltrate", "(Fig.", "5B).", "Hematopoiesis", "was", "evident", "in", "the", "red", "pulp", "and", "distinguishable", "from", "the", "Iymphoblastoid", "infiltrate", "as", "confirmed", "by", "the", "PAS", "and", "esterase", "stains.", "This", "lymphoblastoid", "infiltrate", "was", "similar", "to", "that", "de-", "scribed", "by", "Rappaport", "et", "al.", "in", "an", "acute", "GVHD", "model", "(22).", "Finally,", "samples", "of", "skin,", "tongue,", "ear,", "heart,", "liver,", "kidney,", "and", "small", "intestine", "from", "CsA-treated", "and", "diluent-control", "animals", "showed", "no", "pathologic", "changes.", "DISCUSSION", "We", "describe", "in", "this", "report", "the", "induction", "of", "a", "syngeneic-", "GVHD-like", "syndrome", "that", "developed", "after", "cessation", "of", "a", "short", "course", "of", "CsA", "treatment", "of", "DBA/2", "mice", "reconstituted", "with", "syngeneic", "bone", "marrow.", "Clinically", "and", "histologically,", "this", "syn-", "drome", "resembled", "acute", "GVHD", "as", "described", "by", "Rappaport", "et", "al.", "(22).", "The", "autoimmune", "disorder", "developed", "rapidly", "after", "removal", "of", "CsA", "and", "was", "fatal", "for", "most", "CsA-treated", "animals.", "Patholog-", "ically,", "there", "was", "multiple", "organ", "involvement", "(large", "intestine,", "spleen,", "thymus).", "Syngeneic-GVHD-like", "syndromes", "have", "been", "described", "fol-", "lowing", "CsA-treatment", "in", "hoth", "the", "rat", "(12,", "13)", "and", "mouse", "(14).", "Although", "syngeneic", "GVHD", "has", "been", "readily", "reproduced", "in", "the", "rat,", "recently", "Chow", "et", "al.", "(15)", "have", "been", "unable", "to", "reproduce", "syngeneic", "GVHD", "in", "mice", "as", "described", "hy", "Cheney", "and", "Sprent", "(14).", "By", "modifying", "several", "parameters,", "we", "were", "able", "to", "induce", "a", "syngeneic", "GVHD-like", "syndrome", "in", "mice,", "thus", "confirming", "the", "earlier", "work", "of", "Cheney", "and", "Sprent", "(14).", "Clearly,", "from", "the", "data", "presented", "here,", "induction", "of", "syngeneic", "GVHD", "cannot", "be", "attrib-", "uted", "to", "any", "one", "modification.", "However,", "of", "the", "parameters", "altered,", "data", "suggest", "that", "age", "and", "strain", "variation", "may", "be", "most", "significant", "(12,", "13,", "21,", "24-26).", "It", "has", "been", "shown", "that", "combi-", "nations", "of", "MHC", "and", "non-MHC", "genes", "of", "the", "donor", "and", "host", "can", "affect", "development", "and", 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531376115+-6129-8.layout.json
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502251729_502251756-19.layout.json
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500692166_500692218-4.layout.json
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509790579+-0598-5.layout.json
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2071493782_3785-3.layout.json
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2022161585_2022161648-47.layout.json
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2028471090_2028471104-5.layout.json
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511781859_511781868-0.layout.json
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505090185+-0192-4.layout.json
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2065449136_9137-0.layout.json
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504989552_504989561-7.layout.json
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500441172+-1192-20.layout.json
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