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508939370_508939517-111.layout.json | [
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1368,
1875,
1400
],
[
1149,
1382,
1331,
1418
],
[
562,
1427,
649,
1481
],
[
1146,
1457,
1260,
1490
],
[
1290,
1462,
1326,
1495
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[
1360,
1465,
1447,
1496
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[
1476,
1468,
1708,
1505
],
[
1733,
1480,
1849,
1510
],
[
1876,
1485,
1919,
1513
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[
569,
1490,
572,
1533
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[
1148,
1494,
1306,
1532
],
[
1334,
1502,
1403,
1536
],
[
1162,
893,
1297,
927
],
[
1327,
900,
1391,
930
],
[
1419,
905,
1721,
947
],
[
1749,
920,
1791,
949
],
[
1158,
931,
1299,
972
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[
1326,
937,
1367,
968
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[
1393,
943,
1553,
976
],
[
1583,
949,
1743,
990
],
[
1153,
1083,
1409,
1125
],
[
1436,
1096,
1525,
1125
],
[
1556,
1101,
1621,
1130
],
[
1153,
1119,
1362,
1155
],
[
1389,
1130,
1430,
1157
],
[
1456,
1132,
1595,
1165
],
[
555,
1577,
670,
1695
],
[
700,
1668,
787,
1699
],
[
933,
1677,
1092,
1711
],
[
1120,
1682,
1328,
1719
],
[
1355,
1697,
1398,
1720
],
[
1426,
1694,
1586,
1733
],
[
1616,
1700,
1681,
1730
],
[
565,
1689,
568,
1742
],
[
932,
1715,
1071,
1747
],
[
1099,
1720,
1233,
1752
],
[
1260,
1728,
1515,
1762
],
[
1541,
1736,
1656,
1767
],
[
1685,
1741,
1821,
1772
],
[
551,
1948,
668,
2012
],
[
696,
1970,
782,
2000
],
[
930,
1976,
1043,
2010
],
[
1070,
1981,
1206,
2016
],
[
1233,
1986,
1465,
2023
],
[
565,
1744,
567,
1767
],
[
931,
1754,
1069,
1785
],
[
1095,
1757,
1374,
1795
],
[
1400,
1768,
1559,
1800
],
[
554,
1770,
716,
1873
],
[
744,
1823,
831,
1853
],
[
931,
1828,
1115,
1862
],
[
1142,
1835,
1184,
1864
],
[
1213,
1837,
1349,
1906
],
[
1376,
1840,
1654,
1887
],
[
1685,
1858,
1843,
1919
],
[
1355,
1886,
1371,
1906
],
[
564,
1884,
565,
1890
],
[
933,
1864,
973,
1894
],
[
1000,
1869,
1137,
1900
],
[
1166,
1874,
1231,
1903
],
[
1256,
1876,
1324,
1906
],
[
563,
1896,
566,
1928
],
[
935,
1901,
1112,
1936
],
[
1144,
1912,
1373,
1944
],
[
1379,
1886,
1420,
1950
],
[
1444,
1881,
1633,
1919
],
[
1657,
1888,
1773,
1919
],
[
1801,
1895,
1912,
1929
],
[
553,
2030,
758,
2097
],
[
789,
2047,
876,
2075
],
[
926,
2052,
1064,
2084
],
[
1094,
2056,
1158,
2084
],
[
1189,
2058,
1325,
2088
],
[
1353,
2064,
1394,
2092
],
[
1421,
2069,
1581,
2098
],
[
1609,
2070,
1812,
2109
],
[
926,
2090,
1042,
2121
],
[
1071,
2092,
1136,
2121
],
[
1163,
2098,
1415,
2131
],
[
1446,
2103,
1537,
2134
],
[
1563,
2106,
1724,
2141
],
[
2078,
2502,
2103,
2586
],
[
2081,
2360,
2109,
2472
]
] |
500441172+-1192-11.layout.json | [
"SUMMARY",
"CHECKLIST",
"OF",
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"a",
"list",
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"the",
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"asked",
"to",
"decide",
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"these",
"words",
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"the",
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"you",
"say",
"the",
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"you",
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"magazine",
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"Funny,",
"or",
"not?",
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"an",
"answer",
"Yes",
"58%",
"No",
"42%",
"Differnence",
"L8",
"not",
"significant.",
"b)",
"Informative,",
"or",
"not?",
"Base:",
"Total",
"people",
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"who",
"gave",
"an",
"answenr",
"Yes",
"47%",
"No",
"53%",
"Differnence",
"is",
"noit",
"sdgnificant.",
"¢}",
"Boring,",
"or",
"not?",
"Base:",
"Total",
"people",
"remembering",
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"who",
"gave",
"an",
"answer",
"Yes",
"19%",
"No",
"81%",
"Difference",
"L8",
"significant.",
"d)",
"Insulting,",
"or",
"not?",
"Base:",
"Total",
"people",
"nemembering",
"\"Magician\"",
"who",
"gave",
"an",
"answex",
"Yes",
"13%",
"No",
"87%",
"Diffehince",
"{4",
"significant.",
"e)",
"Interesting,",
"or",
"not?",
"Base:",
"Total",
"people",
"remembenring",
"\"Magician\"",
"who",
"gave",
"an",
"answer",
"Yes",
"75%",
"No",
"25%",
"Difference",
"is",
"significant,",
"(31)",
"(32)",
"(32)",
"(31}",
"(32)",
"eali",
"awQds"
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[
526,
677,
644,
710
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[
667,
675,
883,
708
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[
911,
675,
1103,
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[
1129,
673,
1185,
701
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[
1209,
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[
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[
264,
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264,
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[
547,
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626,
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[
184,
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213,
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[
264,
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396,
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[
423,
827,
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[
484,
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560,
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[
266,
855,
356,
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[
404,
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501,
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[
525,
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642,
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[
666,
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[
911,
851,
1102,
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[
1129,
850,
1184,
875
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[
1209,
858,
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[
1310,
858,
1346,
875
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[
1371,
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875
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[
263,
894,
320,
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[
346,
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399,
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[
543,
892,
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[
606,
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[
263,
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[
483,
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544,
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[
182,
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212,
1024
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[
264,
996,
454,
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[
483,
1003,
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[
543,
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[
264,
1030,
354,
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[
384,
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[
504,
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[
645,
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[
1106,
1026,
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[
1187,
1034,
1264,
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[
1288,
1034,
1325,
1052
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[
1349,
1032,
1466,
1052
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[
262,
1070,
318,
1091
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[
345,
1068,
397,
1090
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[
541,
1068,
579,
1089
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[
605,
1066,
659,
1089
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[
262,
1101,
458,
1132
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[
482,
1100,
516,
1125
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[
543,
1096,
776,
1131
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[
182,
1175,
210,
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[
262,
1174,
493,
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[
522,
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[
582,
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[
262,
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[
402,
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497,
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[
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[
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[
908,
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1125,
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1205,
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1306,
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1344,
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[
1368,
1211,
1485,
1231
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[
260,
1250,
317,
1282
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[
343,
1248,
397,
1269
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[
540,
1248,
578,
1268
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[
604,
1246,
658,
1268
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[
260,
1279,
457,
1310
],
[
480,
1278,
515,
1303
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[
541,
1275,
774,
1310
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[
1541,
495,
1603,
526
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[
1539,
672,
1603,
704
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[
1539,
848,
1602,
879
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[
1537,
1024,
1600,
1056
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[
1535,
1203,
1599,
1235
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[
1585,
2107,
1605,
2186
],
[
1586,
1978,
1608,
2078
]
] |
0001007338-5.layout.json | [
"492",
"SCHUSTER",
"&",
"THOMPSON",
"quently,",
"the",
"relative",
"preference",
"for",
"an",
"alcohol",
"versus",
"tap",
"water",
"solution",
"was",
"tested,",
"Preference",
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"alcohol",
"solutions",
"increased",
"directly",
"as",
"a",
"function",
"of",
"dosage",
"of",
"previous",
"intraventricular",
"injection.",
"Schiesinger,",
"Kakihana",
"&",
"Bemnett",
"(/1)",
"have",
"shown",
"that",
"tetracthyl-",
"thiuram-disulfide",
"(antabuse)",
"causes",
"a",
"significant",
"decrement",
"in",
"alcohel",
"ingestion",
"in",
"several",
"strains",
"of",
"mice",
"varying",
"in",
"Uheir",
"propensity",
"to",
"drink",
"ab-",
"while",
"water",
"intake",
"was",
"unaffected.",
"ORGANISMIC",
"VARTADLES",
"It",
"is",
"obvious",
"that",
"humans",
"exhibit",
"marked",
"individual",
"differences",
"in",
"their",
"propensity",
"to",
"become",
"dependent",
"upon",
"drugs.",
"It",
"is",
"unknown",
"whether",
"such",
"individual",
"differences",
"are",
"attributable",
"to",
"a",
"genetic",
"predisposition",
"to",
"drug",
"de-",
"pendence.",
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"the",
"incidence",
"of",
"drug",
"dependence",
"in",
"man",
"has",
"been",
"shown",
"to",
"vary",
"as",
"a",
"function",
"of",
"sex",
"as",
"well",
"as",
"age.",
"The",
"purpose",
"of",
"the",
"present",
"section",
"is",
"to",
"review",
"the",
"studies",
"relating",
"these",
"organismic",
"variables",
"to",
"the",
"self-administration",
"of",
"drugs.",
"Genetic",
"variables—Willizms",
"(72)",
"bas",
"proposed",
"a",
"genetic",
"basis",
"for",
"alco-",
"holism",
"based",
"on",
"the",
"conception",
"that",
"inherited",
"nutritional",
"deficiencies",
"may",
"enhance",
"the",
"reinforcing",
"properties",
"of",
"alcohol,",
"Animals",
"maintained",
"on",
"a",
"marginal",
"diet",
"develop",
"an",
"appetite",
"for",
"alcohol",
"which",
"dectines",
"if",
"various",
"vita-",
"mins",
"are",
"added",
"to",
"the",
"diet,",
"The",
"interpretation",
"of",
"these",
"experiments",
"is",
"com-",
"plicated",
"by",
"the",
"fact",
"that",
"vitamin",
"deficiencics",
"can",
"cause",
"a",
"decrease",
"in",
"food",
"intake",
"which",
"in",
"turn",
"may",
"increase",
"alcohel",
"consumption,",
"Thus,",
"the",
"increased",
"consumption",
"may",
"be",
"attribatable",
"to",
"the",
"animals’",
"caloric",
"deficiency.",
"This",
"interpretation",
"is",
"supported",
"by",
"the",
"fact",
"that",
"the",
"increased",
"preference",
"for",
"alcohol",
"in",
"nutritionally",
"deficient",
"animals",
"is",
"abolished",
"if",
"a",
"sucrose",
"solu-",
"tion",
"is",
"offered",
"in",
"addition",
"to",
"alcohol",
"and",
"water",
"[Lester",
"&",
"Greenberg",
"(15);",
"Mardones",
"et",
"al.",
"(73)1.",
"Evidence",
"for",
"a",
"genetic",
"predisposition",
"for",
"alcohol",
"consumption",
"has",
"been",
"shown",
"for",
"rats",
"[Myers",
"(74)]",
"as",
"well",
"as",
"various",
"strains",
"of",
"mice",
"[MeClearn",
"&",
"Rodgers",
"(75)).",
"Several",
"interesting",
"biochemical",
"differences",
"have",
"been",
"shown",
"to",
"correlate",
"with",
"the",
"propensity",
"of",
"various",
"strains",
"of",
"mice",
"to",
"ingest",
"alcohol.",
"Strain",
"differences",
"in",
"alcohol",
"prefercrice",
"have",
"been",
"shown",
"to",
"parallel",
"the",
"overall",
"activity",
"of",
"liver",
"alcohol",
"dehydrogenase",
"in",
"in",
"witro",
"studies",
"[Rodgers",
"et",
"al.",
"(76);",
"McClearn",
"et",
"&l",
"(77)].",
"Unfortunately,",
"in",
"wivo",
"studies",
"of",
"the",
"metabolism",
"of",
"alcohol",
"by",
"these",
"strains",
"of",
"mice",
"have",
"failed",
"to",
"demonstrate",
"a",
"comparable",
"correlation",
"between",
"rate",
"of",
"aicohol",
"me-",
"tabolism",
"and",
"aicohol",
"preference",
"[Rodgers",
"&",
"McClearn",
"(78);",
"Schlesinger",
"(79);",
"Benett",
"&",
"Herbert",
"(80)].",
"Further,",
"Rodgers",
"&",
"McClearn",
"(81)",
"have",
"more",
"recently",
"reported",
"that",
"strains",
"of",
"mice",
"which",
"show",
"a",
"preference",
"for",
"over",
"water",
"show",
"an",
"even",
"greater",
"preference",
"for",
"a",
"sucrose",
"solu-",
"tion.",
"Another",
"interesting",
"correlation",
"has",
"been",
"shown",
"between",
"accumulation",
"of",
"acetaldehyde",
"following",
"the",
"injection",
"of",
"alcohol",
"into",
"high-preference",
"strains",
"of",
"mice",
"(C",
"57",
"BL)",
"and",
"mice",
"which",
"avoid",
"alcohol",
"ingestion",
"(DBA/2).",
"The",
"DBA/2",
"strain",
"show",
"significantly",
"greater",
"acetaldehyde",
"levels",
"one",
"hour",
"SELF",
"ADMINISTRATION",
"OF",
"DRUGS",
"433",
"after",
"alcohol",
"administration",
"than",
"the",
"C",
"57",
"BL",
"mice.",
"The",
"known",
"aversive",
"properties",
"of",
"acetaldehyde",
"suggest",
"that",
"the",
"accumulation",
"of",
"this",
"metabotic",
"breakdown",
"product",
"of",
"alcohol",
"may",
"account",
"for",
"the",
"aversiveness",
"of",
"alcahol",
"in",
"the",
"DBA/Z",
"strain",
"[Schlesinger,",
"Kakihana",
"&",
"Bennett",
"(71)].",
"A",
"recent",
"report",
"by",
"Nichols",
"&",
"Hstao",
"(82)",
"has",
"shown",
"that",
"rats",
"can",
"be",
"selectively",
"bred",
"for",
"their",
"ability",
"to",
"be",
"conditioned",
"to",
"drink",
"a",
"morphine",
"sl",
"tion.",
"Tnbreeding",
"of",
"the",
"more",
"“susceptible”",
"rats",
"fram",
"an",
"unselected",
"popula-",
"tion",
"produced",
"“susceptible”",
"offspring.",
"In",
"addition,",
"the",
"inbreeding",
"“resistant”",
"rats",
"produced",
"“resistant”",
"offspring.",
"Further",
"inbreeding",
"increased",
"the",
"strain",
"differences",
"in",
"successive",
"generations.",
"Cross-fostering",
"studies",
"ruled",
"out",
"differcnces",
"in",
"maternal",
"care",
"as",
"a",
"variable.",
"Of",
"further",
"interest",
"is",
"the",
"fact",
"that",
"the",
"susceptible",
"and",
"resistant",
"rats",
"in",
"the",
"F-3",
"generation",
"also",
"showed",
"a",
"significant",
"difference",
"in",
"their",
"alcohol",
"intake",
"in",
"preference",
"tests",
"conducted",
"14",
"days",
"after",
"being",
"conditioned",
"to",
"drink",
"alchol.",
"The",
"morphine",
"“suscepti-",
"ble”",
"strain",
"drank",
"twice",
"as",
"much",
"alcoho!",
"as",
"the",
"animals",
"bred",
"for",
"“resistance”",
"to",
"drinking",
"morphine.",
"Nichols",
"(83)",
"has",
"shawn",
"that",
"these",
"strain",
"differences",
"are",
"uncorrelated",
"with",
"emotionality",
"as",
"measured",
"by",
"the",
"Hall",
"open-field",
"test.",
"There",
"is",
"&",
"positive",
"correlatian,",
"however,",
"hetween",
"maze",
"loarning",
"ability",
"and",
"to",
"conditioned",
"morphine",
"ingestion.",
"The",
"meaning",
"of",
"this",
"correlation,",
"however,",
"is",
"obscure.",
"Sex.—At",
"present",
"the",
"sex",
"of",
"the",
"experimental",
"animal",
"has",
"been",
"studied",
"only",
"in",
"reference",
"to",
"alcohol",
"self-administration.",
"Sex",
"has",
"heen",
"reported",
"to",
"be",
"untefated",
"to",
"alcohol",
"preference",
"in",
"Sprague-Dawley",
"rats",
"{Mardones",
"(67);",
"Zarcow,",
"Aduss",
"&",
"Denisou",
"(16)]",
"and",
"various",
"strains",
"of",
"mice",
"[Kalkihana",
"&",
"McClearn",
"(84)5",
"McClearn",
"&",
"Rodgers",
"(75);",
"Mirone",
"(85)].",
"In",
"contrast,",
"a",
"tendency",
"for",
"male",
"rats",
"[Clay",
"(86)]",
"and",
"mice",
"to",
"consume",
"more",
"alcohol",
"has",
"been",
"noticed.",
"This",
"difference",
"is",
"even",
"more",
"marked",
"when",
"the",
"females",
"are",
"in",
"heat.",
"The",
"findings",
"of",
"Aschkenasy-Lelu",
"(87)",
"indicate",
"that",
"this",
"is",
"probably",
"related",
"to",
"the",
"suppressant",
"effects",
"of",
"estrogens",
"on",
"alcohol",
"intake.",
"This",
"effect",
"of",
"estrogen",
"is",
"ot",
"specific",
"to",
"alcohol",
"ingestion,",
"hawever,",
"since",
"ingestion",
"of",
"saline",
"or",
"sucrose",
"solutions",
"is",
"as",
"well",
"suppressed,",
"Rodgers",
"(88)",
"has",
"shown",
"a",
"direct",
"correlation",
"between",
"liver",
"size",
"and",
"alco-",
"hol",
"consumption",
"of",
"C",
"57",
"BL/Crgl",
"mice",
"during",
"pregnancy",
"and",
"while",
"nurs-",
"ing",
"ten-day-old",
"litters.",
"As",
"Lester",
"(68)",
"pointed",
"out,",
"“it",
"would",
"be",
"hazardous",
"{and",
"simplistic)",
"to",
"conclude",
"that",
"the",
"male:female",
"ratio",
"of",
"human",
"alecholism",
"is",
"in",
"any",
"way",
"re-",
"tated",
"to",
"differcnces",
"in",
"estrogen",
"fevels.”",
"Age—The",
"reports",
"relating",
"age",
"to",
"the",
"ingestion",
"of",
"alcohol",
"indicate",
"spe-",
"cies",
"differences",
"as",
"a",
"function",
"of",
"this",
"variable.",
"In",
"mice",
"of",
"BALB/",
"strain,",
"alcohol",
"preference",
"is",
"greater",
"at",
"4",
"weeks",
"of",
"age",
"than",
"at",
"16",
"weeks",
"[Kakihana",
"&",
"McClearn",
"(84)].",
"In",
"contrast,",
"Wallgren",
"&",
"Forsander",
"(89)",
"found",
"thad",
"in",
"rats",
"alcohol",
"preference",
"increased",
"as",
"a",
"function",
"of",
"age.",
"Nichols",
"(90)",
"reported",
"that",
"conditioned",
"morphine",
"ingestion",
"declines",
"as",
"a",
"function",
"of",
"the",
"age",
"of",
"the",
"rats.",
"The",
"significance",
"of",
"these",
"findings",
"concern-",
"ing",
"changes",
"in",
"the",
"self-administration",
"of",
"drugs",
"as",
"a",
"function",
"of",
"age",
"await",
"2",
"maore",
"precise",
"specification",
"of",
"the",
"correlated",
"physiclogical",
"changes."
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524860047+-0116-41.layout.json | [
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"8:50",
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502835948+-5959-7.layout.json | [
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1704,
1164
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1724,
1141,
1751,
1162
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1285,
1191,
1366,
1215
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1453,
1199,
1491,
1220
],
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1512,
1201,
1679,
1231
],
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1705,
1208,
1826,
1237
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1214,
1995,
1243
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2021,
1221,
2089,
1245
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1228,
1400,
1252
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1647,
1259
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1246,
1842,
1266
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1862,
1249,
2011,
1278
],
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1260,
2104,
1275
],
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1283,
1260,
1347,
1282
],
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1367,
1269,
1558,
1290
],
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1577,
1272,
1629,
1292
],
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1648,
1275,
1733,
1301
],
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1758,
1278,
1963,
1305
],
[
1985,
1289,
2014,
1307
],
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2037,
1288,
2084,
1310
],
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2106,
1291,
2189,
1313
],
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1280,
1294,
1326,
1315
],
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1351,
1297,
1397,
1318
],
[
1419,
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1610,
1326
],
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1632,
1309,
1750,
1337
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1771,
1314,
1891,
1336
],
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1911,
1317,
1979,
1340
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[
2000,
1320,
2067,
1343
],
[
2082,
1321,
2166,
1356
],
[
1276,
1329,
1346,
1351
],
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1368,
1332,
1396,
1353
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1418,
1338,
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1367
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1664,
1342,
1714,
1366
],
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1734,
1348,
1883,
1373
],
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2039,
1350,
2042,
1355
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1448,
1403,
1534,
1425
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1555,
1407,
1588,
1427
],
[
1610,
1408,
1641,
1429
],
[
1659,
1413,
1801,
1441
],
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1821,
1416,
1958,
1441
],
[
1977,
1421,
2063,
1444
],
[
1274,
1433,
1410,
1455
],
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1432,
1435,
1532,
1459
],
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1556,
1440,
1623,
1462
],
[
1642,
1447,
1815,
1469
],
[
1836,
1451,
2042,
1477
],
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2062,
1458,
2097,
1478
],
[
1273,
1462,
1359,
1486
],
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1377,
1468,
1444,
1492
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1465,
1470,
1580,
1499
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1605,
1476,
1738,
1504
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1918,
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1939,
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1989,
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2011,
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2075,
1511
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1270,
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1408,
1523
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1430,
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1524
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1499,
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1530,
1526
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1552,
1507,
1701,
1532
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1725,
1515,
1796,
1535
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1816,
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1971,
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1993,
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2044,
1531,
2091,
1546
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1269,
1531,
1336,
1552
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1359,
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1409,
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1428,
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1603,
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1637,
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1657,
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1706,
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1725,
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1954,
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2063597106_2063597113-2.layout.json | [
"Table",
"1.—Distribution",
"of",
"Lung",
"Cancer",
"Cases",
"and",
"Controls",
"According",
"to",
"Selected",
"Demographic",
"o",
"Cases,",
"Controls",
".",
"Characteristics",
"Spouse",
"Ever",
"Smoked",
"No.",
"Expossed/",
"No.",
"Exposéw",
"Crude",
"OR",
"Adjusted",
"OR",
"L",
"o",
"o",
"Lung",
"Cancer",
"Population",
"—",
"Tobacco,",
"by",
"Type",
"No.",
"of",
"Casest",
"__No.",
"of",
"Controis",
"(95%",
"C1)",
"(95%",
"C1)",
"Cases,",
"Controls,",
"ung",
"carcinomas",
"Characteristic",
"No.",
"(%)",
"No.",
"(%)'",
"Any",
"type",
"of",
"tobacco",
"433/651",
"766/1253",
"1.26",
"{1.04-1.54)%",
"1.29",
"{1.04-1.60)t",
"Study",
"center",
"Cigarettes",
"386/648",
"691/1253",
"1.20",
"(0.99-1.45)",
"1.18",
"{0.96-1.46)",
"Atfanta,",
"Ga",
"46",
"(7.0)",
"76",
"(6.1)",
")",
"Houston,",
"Tex",
"41",
"(6:3)",
"42(3.4)",
"Cigars",
"85/641",
"138/1253",
"1.24",
"(0.93-1.85)",
"1.25",
"(0.92-1.71)",
"Los",
"Angeles,",
"Calif",
"264",
"(40.4)",
"512",
"(40.9)",
"Pipes",
"86/640",
"158/1253",
"1.08",
"(0.81-1.43)",
"1.19",
"(0.88-1.60)",
"New",
"Orleans,",
"La",
"34(5.2)",
"57",
"(4.5)",
"Adenocarcinoma",
"San",
"Francisco",
"Bay",
".",
"-1",
"Calit",
"268",
"(41.0)",
"566",
"(45.2)",
"Any",
"type",
"of",
"tobacco",
"334/496",
"766/1253",
"1.31",
"(1.05-1.63)t",
"1.28",
"(1.01-1.62)1",
"Respondent",
"Cigarettes",
"298/493",
"691/1253",
"1.24",
"(1.01-1.54)t",
"1.18",
"(0.94-1.49)",
"Study",
"subject",
"412",
"(63.1)",
"1253",
"(100.0)",
"i",
"1.0",
"79-",
"8",
"(0.76-1.53]",
"Next",
"of",
"kin",
"241",
"(36.9)",
")",
"Cigars",
"58/489",
"138/1253",
"9",
"(0.79-1.51)",
"1.08",
"{(",
")",
"Age,y",
".",
"Pipes",
"62/488",
"158/1253",
"1.01",
"(0.74-1.38)",
"1.04",
"(0.75-1.46)",
"<50",
"70",
"(10.7)",
"165",
"(13.1)",
"Other",
"histological",
"types",
"g&gg",
";",
":g",
"g’g'g;",
":13",
"gg",
"gfig;",
"Any",
"type",
"of",
"tobacco",
"99/155",
"766/1253",
"1.12",
"(0.80-1.59)",
"1.37",
"(0.92-2.03)",
"70-79",
"260",
"(39:3)",
"536",
"(42:3)",
"Cigarettes",
"88/155",
"691/1253",
"1.07",
"(0.76-1.50)",
"1.20",
"(0.83-1.75)",
"Ravcfilethnic",
"group",
"282",
"(58",
"Cigars",
"27/152",
"138/1253",
"1.75(1.11-2.74)",
"1.88",
"(1.14-3.08)1",
"ite",
".",
"765",
"(61.1)",
"Black",
"171",
"(13.7)",
"Pipes",
"24/152",
"158/1253",
"1.30",
"(0.82-2.07)",
"1.79",
"(1.08-2.95)1",
"]",
"Annual",
"income,",
"$",
"+P<.05",
"<8000",
"103",
"(15.8)",
"144",
"(11.5)",
"e",
"?go&'gag%%",
"9",
"gfi",
"g",
"ggg",
":gg",
"ggg;",
"Table",
"3.—Association",
"Between",
"Risk",
"of",
"Lung",
"Cancer",
"and",
"Pack-Years",
"of",
"Environmental",
"Tobacco",
"Smoke",
"20",
"000-34",
"999",
"114",
"(17:5)",
"250",
"(19:9)",
"Exposure",
"From",
"Spouse(s)",
"Among",
"Nonsmoking",
"Women*",
"999",
"3",
"g?,zz,‘)",
";?g",
"ggg;",
"Pack-Years",
"of",
"Crude",
"OR",
"Adjusted",
"OR",
"Unknown",
"or",
"refused",
"Exposure",
"Cases",
"Controls",
"(95%",
"C1)",
"(95%",
"CI)",
"to",
"answer",
"107",
"(16.4)",
"177",
"(14.1)",
"All",
"lung",
"carcinomas",
"Education",
"(",
"0",
"267",
"562",
"1.00",
"1.00",
"<High",
"schoal",
"216",
"(33.1)",
"266",
"(21.2)",
"High",
"schaol",
"217",
"(33.2)",
"303",
"(31.4)",
"=15.0",
"146",
"300",
"1.02",
"(0.80-1.31)",
"1.08",
"(0.83-1.39)",
"Some",
"college",
"99",
"(15.2)",
"315",
"(25.1)",
"15.1-39.9",
"92",
"190",
"1.02",
"(0.76-1.36)",
"1.04",
"(0.76-1.42)",
"gfggg:te",
"&2",
"Egg;",
"154",
"gza?",
"40.0-79.9",
"80",
"126",
"1.34",
"(0.98-1.83)",
"1.36",
"(0.97-1.91)",
"Unknown",
"9(0.7)",
"=80.0",
"24",
"27",
"1.87",
"(1.06-3.31)t",
"1.79",
"{0.99-3.25)",
"Trend",
"P=.03",
"Trend",
"P=.03",
"exposures",
"may",
"oceur",
"concurrently.",
"Otter",
"tistological",
"types",
"68",
"562",
"1.00",
"1.00",
".",
"!",
"16.1-38.8",
"22",
"190",
"0.96",
"(0.58-1.59)",
"1.12",
"{0.64-1.96)",
";llssignamc",
"122",
"g",
"g;‘;",
"1:3",
"g‘?)fl",
"*Adjusted",
"for",
"age;",
"race",
"(white,",
"black,",
"Asian,",
"and",
"Hispanic",
"or",
"other);",
"study",
"area",
"(Los",
"Angeles,",
"Calif,",
"San",
"Francisco",
"Other",
"172",
"é)",
"23",
"(1",
"é)",
"Bay",
"Area,",
"Calif,",
"South);",
"education",
"(less",
"than",
"high",
"school,",
"high",
"school",
"graduate,",
"some",
"college",
"or",
"more);",
"fruits,",
"Unknown",
"or",
"refused",
".",
"\"",
"vegetables,",
"and",
"suppiemental",
"vitamin",
"index;",
"dietary",
"cholesterol;",
"family",
"history",
"of",
"lung",
"cancer;",
"and",
"employment",
"in",
"to",
"answer",
"1(0.2)",
"11",
"(0.9)",
"high-risk",
"occupations.",
"OR",
"indicates",
"odds",
"ratio;",
"Cl,",
"confidence",
"interval.",
"1The",
"number",
"of",
"cases",
"and",
"controls",
"with",
"responses",
"to",
"each",
"question.",
"represent",
"the",
"sum",
"of",
"reported",
"years",
"of",
"Ad:",
"nocarcinoma",
"199",
"562",
"1.00",
"1.00",
"exposure",
"E}’Irsdfi?rgheach",
"mdlwdua(.il",
"=15.0",
"109",
"300",
"1.03",
"{0.78-1.35)",
"1.06",
"(0.80-1.40)",
"sgfircehm",
"Chflh",
".",
"d°°",
"(",
"g",
"e)r",
"’",
"K}Othggita%",
"15.1-39.9",
"70",
"190",
"1.04",
"(0.76-1.43)",
"1.02",
"(0.72-1.42)",
"OuSi",
"Oh",
"me!?l",
"leé‘s",
"orin",
"a",
"€",
"40.0-79.9",
"65",
"126",
"1.46",
"(1.04-2.05)t",
"1.41",
"(0.98-2.03)",
"(spouse,",
"other",
"household",
"members,",
"occu-",
"-~",
"18",
"27",
"1.88",
"(1.02-3.49)1",
"173",
"(0.913.31)",
"pational,",
"and",
"social).",
"The",
"variable",
"does",
"Trend",
"Pe.01",
"Trand",
"F=.05",
"not",
"represent",
"years",
"per",
"se",
"because",
"these",
"e",
"—",
"e",
"ggfiffofsor;sbvlvn;%",
"Z‘;:Z‘;",
"=15.0",
"37",
"300",
"1.02",
"(0.67-1.56)",
"118",
"(0.751.87)",
"of",
"adenocarcinoma",
"of",
"the",
"lung",
"(76.1%",
"of",
"the",
"total",
"cases)",
"and",
"other",
"histological",
"40.0-79.8",
"15",
"126",
"0.98",
"(g-::i",
"-78)",
"1.16",
"(0.62-2.19)",
"types",
"combined",
"(squamous",
"cell",
"carcinoma,",
"=800",
"6",
"2",
"1.84(0.73-4.61)",
"197",
"(0.75-5.19)",
"small-cell",
"carcinoma,",
"large-cell",
"carcinoma,",
"and",
"other",
"types,23.9%",
"of",
"the",
"total",
"cases).",
"In",
"addition,",
"analyses",
"restricted",
"to",
"self-",
"respondents",
"were",
"compared",
"with",
"those",
"that",
"also",
"included",
"proxy",
"respondents.",
"Unconditional",
"logistic",
"regression",
"analyses",
"were",
"used",
"to",
"estimate",
"the",
"asso-",
"ciations",
"by",
"summary",
"adjusted",
"ORs,",
"95%",
"Cls,",
"and",
"test",
"statistics.**2",
"The",
"ORs",
"were",
"adjusted",
"for",
"design",
"or",
"sampling",
"variables",
"(age,",
"race,",
"and",
"study",
"center),",
"as",
"well",
"as",
"education,",
"family",
"history",
"of",
"lung",
"cancer,",
"employment",
"in",
"potentially",
"high-risk",
"occu-",
"pations",
"for",
"5",
"or",
"more",
"years",
"(production",
"jobs",
"in",
"painting,",
"mining,",
"textile,",
"insula-",
"tion,",
"shipyard,",
"cement,",
"roofing,",
"smelting,",
"radiation,",
"petroleum,",
"hairdressing,",
"and",
"printing",
"industries),",
"dietary",
"cholesterol",
"intake,",
"and",
"an",
"index",
"of",
"dietary",
"antioxidant",
"1754",
"JAMA,",
"June",
"8,",
"1994—Vol",
"28.",
"No.",
"22",
"*Adjusted",
"for",
"age;",
"race;",
"study",
"area;",
"education;",
"fruits,",
"vegetables,",
"and",
"supplegnental",
"vitamin",
"index;",
"dietary",
"cholestsrol;",
"family",
"history",
"of",
"lung",
"cancer;",
"and",
"employment",
"in",
"high-risk",
"occupations.",
"OR",
"indicates",
"odds",
"ratio;",
"Cl,",
"confidence",
"interval.",
"TP<.05.",
"consumption",
"based",
"on",
"weekly",
"consump-",
"tion",
"of",
"fruits",
"and",
"vegetables",
"and",
"supple-",
"mental",
"vitamin",
"use",
"at",
"least",
"four",
"times",
"per",
"week.",
"No",
"significant",
"interactions",
"were",
"observed.",
"Previous",
"lung",
"disease",
"and",
"di-",
"etary",
"beta",
"carotene,",
"vitamin",
"C,",
"and",
"vita-",
"min",
"E",
"were",
"also",
"evaluated,",
"but",
"were",
"not",
"included",
"in",
"the",
"final",
"models",
"because",
"they",
"did",
"not",
"confound",
"the",
"ETS",
"findings",
"and",
"did",
"not",
"contribute",
"further",
"to",
"the",
"association",
"between",
"ETS",
"and",
"lung",
"cancer.",
"Trend",
"P=.64",
"Trend",
"P=.29",
"racial/ethnic;",
"group,",
"annual",
"household",
"in-",
"come,",
"and",
"highest",
"level",
"of",
"education",
"com-",
"pleted",
"isshown",
"in",
"Table",
"1.",
"Approximately",
"40%",
"of",
"the",
"lung",
"cancer",
"cases",
"and",
"controls",
"were",
"residents",
"of",
"Los",
"Angeles",
"and",
"a",
"simi-",
"lar",
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0001461870-0.layout.json | [
"BROWN",
"&",
"WILLIAMSON",
"TOBACCO",
"CORPORATION",
"RESEARCH",
"&",
"DEVELOPMENT",
"FILE",
"NOTE",
"TITLE:",
"IDENTIFICATION",
"AND",
"QUANTITATION",
"OF",
"AN",
"UNKNOWN",
"COMPONENT",
"IN",
"PHILIP",
"MORRIS",
"CIGARETTE",
"BRANDS/312",
"AUTHOR:",
"S.",
"C.",
"Moldoveanu",
"DATE:",
"September",
"23,",
"1987",
"cc:",
"M.",
"L.",
"Reynolds,",
"T.",
"F.",
"Riehl,",
"J.",
"H.",
"Lauterbach,",
"J.",
"F.",
"Nall,",
"D.",
"A.",
"Colby,",
"B.",
"B.",
"Chakraborty,",
"W.",
"H.",
"Deines,",
"J.",
"Y.",
"Tang,",
"E.",
"F.",
"Litzinger,",
"E.",
"D.",
"Alford,",
"C.",
"N.",
"Kounmas,",
"T.",
"E.",
"Bobbitt,",
"R.",
"R.",
"Johnson,",
"A.",
"McMurtrie,",
"D.",
"V.",
"Cantrell,",
"P.",
"R.",
"Fisher,",
"V.",
"L.",
"Geiss",
"An",
"unknown",
"additive",
"has",
"been",
"detected",
"in",
"all",
"Philip",
"Morris",
"(PM)",
"cigarette",
"brands'.",
"The",
"presence",
"of",
"the",
"umknown",
"was",
"observed",
"as",
"an",
"unidentified",
"peak",
"during",
"the",
"HPLC",
"analysis",
"of",
"licorice.",
"The",
"identification",
"of",
"this",
"PM",
"additive",
"has",
"been",
"completed.",
"The",
"substance",
"is",
"propyl-para-hydroxy-benzoate:",
"ClOO—CH,—CH,—CH.",
"OH",
"CyoH",
"1,0,",
"=",
"180.21",
"The",
"substance",
"is",
"known",
"to",
"be",
"used",
"to",
"prevent",
"the",
"growth",
"of",
"fungus",
"and",
"yeast",
"in",
"food",
"products",
"and",
"flavor",
"compositions?",
"(see",
"also",
"attachment).",
"The",
"use",
"of",
"the",
"substance",
"on",
"tobacco",
"and",
"methods",
"of",
"analysis",
"have",
"been",
"reported",
"iam",
"the",
"literature’",
".",
"621059198"
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2022161585_2022161648-27.layout.json | [
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0001007338-2.layout.json | [
"486",
"SCHUSTER",
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"THOMPSON",
"20)].",
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"In",
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"Senter",
"&",
"Sinclair",
"(22)",
"tested",
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"on",
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"second",
"fever,",
"Falk",
"(24)",
"has",
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"used",
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"method",
"to",
"assess",
"motivational",
"properties",
"of",
"water",
"under",
"these",
"conditions.",
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"and",
"pentobarbital",
"sodium",
"solutions",
"were",
"made",
"available,",
"and",
"measures",
"of",
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"pressing",
"and",
"fluid",
"ingestion",
"were",
"reliably",
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"Claghorn",
"&",
"Schoolar",
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"chlordiazepoxide,",
"mepraha-",
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"acid",
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"and",
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"drinking",
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"[",
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"solution",
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"tap",
"water",
"remained",
"even",
"after",
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"30",
"day",
"period",
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"which",
"only",
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"solution",
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"the",
"final",
"phase",
"(25",
"days)",
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"ment",
"the",
"rats",
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"trained",
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"tube",
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"consumed",
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"the",
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"days",
"of",
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"drug",
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"Subscquent",
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"refnforcement,",
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"niot",
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"with",
"LSD",
"or",
"quinine.",
"Procedures",
"for",
"chromic",
"venous",
"and",
"arterial",
"catheterization",
"have",
"been",
"widely",
"used",
"in",
"physiological",
"and",
"pharmacological",
"research.",
"[Weeks",
"(26)].",
"Q1",
"The",
"significant",
"development",
"for",
"studies",
"of",
"drug",
"dependence",
"was",
"the",
"ar-",
"rangement",
"for",
"an",
"animal",
"to",
"control",
"the",
"operation",
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"an",
"infusion",
"pump",
"con-",
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"chronic",
"venous",
"catheter.",
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"first",
"report",
"of",
"in-",
"sclf-administeation",
"in",
"rats",
"was",
"presented",
"by",
"Weeks",
"(27).",
"Yana-",
"gita,",
"Deneay,",
"&",
"Seevers",
"(28)",
"and",
"Schuster",
"&",
"Thompsun",
"{29)",
"described",
"wrhruuic",
"intravenous",
"sel",
"Ladininistration",
"methods",
"for",
"Rhesus",
"monkeys,",
"a",
"<",
"N",
"SELF",
"ADMINISTRATION",
"OF",
"DRUGS",
"487",
"Weeks'",
"initial",
"method",
"was",
"applied",
"to",
"study",
"self-administration",
"of",
"mor-",
"ohine",
"(27,",
"30},",
"and",
"his",
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"polyethylene-silicone",
"rubber",
"venous",
"catheter",
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"described",
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"{Weeks",
"&",
"Davis",
"(31)].",
"Other",
"sys-",
"tems",
"for",
"rats",
"have",
"been",
"described",
"by",
"Davis",
"(32)",
"and",
"Pickens",
"(33).",
"Schuster",
"&",
"Thompson",
"(29)",
"used",
"a",
"chronic",
"palyethylene",
"catheter",
"and",
"motorpowered",
"syringe-driver",
"to",
"study",
"morphine",
"self-administration",
"in",
"re-",
"strained",
"monkeys.",
"Yanagita,",
"Deneau",
"&",
"Seevers",
"(28)",
"developed",
"a",
"partial",
"re-",
"straint",
"system",
"for",
"studying",
"drug",
"self-administration",
"by",
"monkeys.",
"The",
"de-",
"vice",
"involved",
"2",
"stainless-steel",
"tubular",
"frame,",
"custom",
"fit",
"to",
"cach",
"animal,",
"which",
"was",
"connected",
"ta",
"the",
"rear",
"corner",
"of",
"a",
"cage",
"via",
"an",
"elbow-hinged",
"cath-",
"etor-protecting",
"arm.",
"Pickens,",
"Hauck",
"&",
"Bloom",
"(34)",
"developed",
"a",
"similar",
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"tial",
"restraint",
"and",
"catheter",
"protection",
"system",
"involving",
"a",
"leather",
"vest",
"and",
"fiexible",
"vinyl",
"covered",
"conduit.",
"Methods",
"for",
"drug",
"self-administration",
"in",
"un-",
"restrained",
"monkeys",
"have",
"been",
"reported",
"by",
"Thompson",
"&",
"Pickens",
"(38).",
"In",
"this",
"method",
"monkeys",
"are",
"fitted",
"with",
"a",
"leather",
"vest",
"and",
"an",
"aluminum",
"backs",
"pack.",
"The",
"back-pack",
"contains",
"2",
"radio",
"receiver",
"and",
"miniature",
"infusion",
"pump.",
"A",
"signal",
"from",
"a",
"remote",
"transmitter",
"is",
"used",
"to",
"activate",
"the",
"infusion",
"pump.",
"Ry",
"using",
"receivers",
"tuned",
"to",
"different",
"frequencies,",
"several",
"animals",
"can",
"live",
"in",
"a",
"common",
"experimental",
"space",
"and",
"independently",
"or",
"concurrently",
"self-ad-",
"minister",
"drugs.",
"VARIABLES",
"INFLUENCING",
"THE",
"SELF-ADMINISTRATION",
"OF",
"DRUGS",
"In",
"this",
"section,",
"studies",
"designed",
"to",
"determine",
"the",
"pharmacological,",
"vr-",
"genismic,",
"and",
"environmental",
"variables",
"affecting",
"drug",
"self-administration",
"are",
"reviewed.",
"It",
"is",
"impossible",
"at",
"this",
"point",
"in",
"the",
"development",
"of",
"this",
"re-",
"search",
"to",
"specify",
"how",
"these",
"variables",
"interact",
"or",
"how",
"they",
"affect",
"the",
"self-",
"administration",
"of",
"different",
"classes",
"of",
"drugs.",
"However,",
"this",
"review",
"may",
"help",
"to",
"stimulate",
"research",
"by",
"pointing",
"out",
"the",
"deficiencies",
"in",
"our",
"knowledge.",
"VHARMACULOGICAL",
"VARIABLES",
"Pharmacological",
"compaunds",
"shown",
"to",
"be",
"reinforcers—Just",
"as",
"food,",
"electrical",
"stimulation",
"of",
"subcortical",
"brain",
"structures,",
"and",
"the",
"opportunity",
"to",
"engage",
"in",
"sexual",
"hehavior",
"all",
"have",
"different",
"reinforcing",
"properties,",
"one",
"might",
"expect",
"different",
"drugs",
"to",
"have",
"different",
"reinforcing",
"effests.",
"The",
"car-",
"liest",
"evidence",
"suggesting",
"that",
"drugs",
"might",
"serve",
"as",
"reinforcers",
"was",
"Sprage’s",
"(36)",
"repot",
"that",
"physically-dependent",
"chimpanzees",
"would",
"engage",
"in",
"behavior",
"which",
"Jed",
"to",
"the",
"experimenter’s",
"administration",
"of",
"morphine",
"Thotgh",
"sustained",
"self-administration",
"was",
"not",
"part",
"of",
"this",
"study,",
"the",
"data",
"suggested",
"that",
"morphine",
"administration",
"maintained",
"the",
"drug-directed",
"be-",
"havior.",
"Beach",
"(37)",
"made",
"a",
"similar",
"observation",
"in",
"rats",
"using",
"a",
"T-maze.",
"The",
"first",
"study",
"demonstrating",
"that",
"morphine",
"served",
"as",
"a",
"reinforeer",
"in",
"rats",
"was",
"by",
"Headlee,",
"Coppock",
"&",
"Nichols",
"(3).",
"Further",
"morphine",
"self-administration",
"studies",
"have",
"been",
"conducted",
"by",
"Weeks",
"(27,",
"30),",
"Schuster",
"&",
"Thompson",
"(29),",
"and",
"Yanagita,",
"Deneau",
"&",
"Seevers",
"(28).",
"Subsequent",
"reports",
"by",
"Weeks",
"&",
"Coltins",
"(38),",
"Thompson",
"&",
"Schuster",
"(39),",
"Collins",
"&",
"Wecks",
"(40),"
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2022161585_2022161648-10.layout.json | [
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"OTHER",
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"PLANS",
"11",
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2073874045_4052-2.layout.json | [
"First,",
"we",
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"off",
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2022161585_2022161648-38.layout.json | [
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2046807567_7643-64.layout.json | [
"11/07/85",
"17:58",
"202",
"637",
"1505",
"PHILIP",
"MORRIS",
"CO",
"CRS-64",
"Critics",
"of",
"OSHA",
"claim",
"that",
"the",
"CAP",
"survey",
"only",
"yielded",
"estimates",
"of",
"potentigl",
"exposure",
"that",
"do",
"not",
"support",
"OSHA’s",
"conclusions.",
"Specifically,",
"the",
"CAP",
"survey",
"asked",
"subjects",
"to",
"record",
"\"simply",
"whether",
"there",
"were",
"any",
"smokers",
"present",
"during",
"the",
"activity,",
"and",
"these",
"smokers",
"could",
"have",
"been",
"present",
"for",
"the",
"entire",
"activity",
"or",
"part",
"of",
"it.”",
"Such",
"data,",
"by",
"design,",
"address",
"only",
"the",
"patential",
"duration",
"of",
"exposure",
"and",
"overestimate",
"actual",
"ETS",
"exposurs,",
"a",
"point",
"made",
"by",
"the",
"study’s",
"authors.",
"Studies",
"that",
"measured",
"cotinine",
"levels",
"in",
"nonsmokers",
"suggest",
"that",
"residential",
"ETS",
"exposure",
"may",
"be",
"more",
"important",
"than",
"warkplace",
"exposure.",
"An",
"international",
"study",
"conducted",
"by",
"the",
"International",
"Agency",
"for",
"Research",
"on",
"Cancer",
"found",
"that",
"average",
"workplace",
"ETS",
"exposure",
"is",
"only",
"sbout",
"one-third",
"of",
"average",
"residential",
"spousal",
"exposure.®’",
"Cotinine",
"levels",
"in",
"the",
"Cummings",
"study",
"also",
"indicated",
"that",
"workplace",
"exposure",
"accounted",
"for",
"a",
"relatively",
"small",
"fraction",
"of",
"total",
"ETS",
"exposure.",
"Cummings",
"found",
"that",
"workplace",
"ETS",
"exposure",
"is",
"associated",
"with",
"a",
"14",
"percent",
"higher",
"average",
"urinary",
"cotinine",
"level",
"among",
"subjects",
"with",
"household",
"ETS",
"exposure",
"(12.8",
"ng/ml",
"vs.",
"11.0",
"ng/m)).",
"Surprisingly,",
"among",
"subjects",
"without",
"household",
"ETS",
"exposure,",
"workplace",
"exposure",
"was",
"associated",
"with",
"a",
"nine",
"percent",
"reduction",
"in",
"the",
"average",
"¢otinine",
"level",
"(7.5",
"ng/ml",
"vs.",
"8.7",
"ng/mh.%",
"Butler",
"provided",
"to",
"OSHA",
"a",
"preliminary",
"analysis",
"of",
"cotinine",
"data",
"collected",
"as",
"part",
"of",
"the",
"National",
"Health",
"and",
"Nutrition",
"Examination",
"Survey",
"Il",
"(NHANES",
"7).",
"The",
"NHANES",
"III",
"data",
"wers",
"collected",
"by",
"the",
"National",
"Center",
"for",
"Health",
"Statistics",
"(NCHS)",
"during",
"1988-19591",
"and",
"represent",
"a",
"nationally",
"representative",
"sample",
"of",
"the",
"U.S.",
"population.",
"Butler",
"restricted",
"the",
"analysis",
"(to",
"the",
"extent",
"possible)",
"to",
"married",
"men",
"and",
"women",
"in",
"the",
"U.S.",
"labor",
"force",
"who",
"are",
"living",
"with",
"their",
"spouse",
"and",
"whose",
"household",
"ETS",
"exposure,",
"if",
"any,",
"is",
"only",
"from",
"2",
"spouse.",
"According",
"to",
"the",
"analysis,",
"this",
"group",
"of",
"workers",
"represents",
"about",
"84",
"percent",
"of",
"the",
"non-smoking",
"U.S.",
"labor",
"force.",
"Butler",
"calculated",
"that",
"the",
"contribution",
"from",
"household",
"ETS",
"sources",
"is",
"greater",
"than",
"that",
"for",
"workplace",
"ETS",
"sources",
"by",
"a",
"factor",
"of",
"2.5",
"for",
"females",
"and",
"8.5",
"for",
"males.",
"For",
"married",
"male",
"and",
"female",
"workers",
"combined,",
"the",
"contribution",
"from",
"household",
"ETS",
"sources",
"is",
"greater",
"than",
"that",
"from",
"warkplace",
"sources",
"by",
"a",
"factor",
"of",
"5.6.",
"It",
"must",
"be",
"emphasized",
"that",
"Butler's",
"apalysis",
"was",
"performed",
"on",
"s",
"“provisional”",
"NHANES",
"Il",
"dataset",
"provided",
"by",
"the",
"NCHS",
"to",
"OSHA.",
"A",
"final",
"copy",
"of",
"the",
"data",
"is",
"expected",
"to",
"be",
"submitted",
"to",
"OSHA",
"in",
"the",
"near",
"future.",
"Because",
"of",
"97",
"Riboli,",
"E.",
"et",
"al.",
"Expoesure",
"of",
"nonsmoking",
"women",
"to",
"environmental",
"tobacco",
"smoke:",
"A",
"10-",
"country",
"collaborative",
"study.",
"Cancer",
"Causes",
"Control",
"v,",
"1,",
"1690",
"p.",
"243,",
"9",
"Cummings",
"indicated",
"that",
"these",
"data",
"may",
"be",
"misleading",
"because",
"many",
"subjects",
"took",
"time",
"off",
"warlk",
"to",
"attend",
"the",
"clinie.",
"Thus,",
"cotinine",
"levels",
"would",
"be",
"more",
"influented",
"by",
"home",
"and",
"public",
"Jocation",
"exposures",
"than",
"by",
"work.",
"However,",
"visiting",
"the",
"clini¢",
"oaly",
"takes",
"a",
"couple",
"of",
"hours,",
"and",
"cotinine",
"measures",
"exposure",
"over",
"the",
"past",
"two",
"days.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"&",
"M",
"q",
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"a",
"“Building",
"Systems",
"Approach”?",
"Why",
"would",
"BCIA",
"and",
"industrial",
"interests",
"want",
"to",
"focus",
"attention",
"on",
"ventitation",
"rather",
"than",
"poilutant",
"sources?",
"Andisthere",
"anything",
"wrong",
"with",
"that",
"after",
"ali?",
"BCIA's",
"members",
"may",
"believethey",
"are",
"well-served",
"by",
"advocating",
"a",
"“building",
"systems",
"approach.”",
"Arguing",
"that",
"indoor",
"air",
"problems",
"are",
"caused",
"by",
"ventilation",
"without",
"addressing",
"poilutant",
"sources",
"implies",
"that",
"the",
"sources",
"are",
"not",
"a",
"problem.",
"Thisisa",
"self-serving",
"argument",
"for",
"manufacturers",
"of",
"prasumed",
"sources",
"of",
"indoor",
"pollution,",
"e.9.,",
"building",
"materials,",
"fumishings,",
"appliances,",
"office",
"equipment,",
"tobacco,",
"and",
"consumer",
"products.",
"BCIA",
"offers",
"memberships",
"on",
"its",
"Board",
"of",
"Directors",
"for",
"a",
"$15,000",
"contribution;",
"regular",
"memberships",
"cost",
"$750/year.",
"BCIA",
"lists",
"as",
"board",
"members",
"several",
"of",
"the",
"largest",
"manufacturers",
"of",
"building",
"materials",
"and",
"products—e.g.,",
"Owens-Coming",
"Fiberglas",
"and",
"Dow",
"Chemical",
"USA,",
"and",
"Union",
"Carbide",
"Corporation.",
"These",
"and",
"othercompanies’",
"products",
"often",
"receive",
"the",
"blame",
"for",
"indoor",
"air",
"qualty",
"problems.",
"In",
"the",
"next",
"few",
"years",
"many",
"of",
"these",
"products",
"are",
"likely",
"to",
"be",
"the",
"subjects",
"of",
"requiatory",
"imt..sves",
"as",
"well",
"as",
"substantial",
"damage",
"claims",
"in",
"litigation.",
"Some",
"have",
"already",
"faeed",
"such",
"regulatory",
"initiatives",
"and",
"paid",
"out",
"millions",
"of",
"dollars",
"in",
"claims.",
"Detaying",
"understanding",
"of",
"pollutant",
"source",
"contributions",
"to",
"indoor",
"air",
"pollution",
"delays",
"potential",
"regulation",
"and",
"reduces",
"the",
"chances",
"of",
"successfui",
"legal",
"action.",
"Such",
"delays",
"allow",
"continued",
"manutacture",
"and",
"sale",
"of",
"the",
"product",
"sources",
"and",
"postpones",
"any",
"costs",
"for",
"required",
"abatement",
"actions",
"or",
"expenses",
"for",
"lawsuit",
"judgements",
"or",
"claims",
"settiements.",
"Delaying",
"payment",
"of",
"fines,",
"legal",
"costs,",
"or",
"settlements,",
"even",
"if",
"the",
"payments",
"are",
"eventually",
"made,",
"is",
"econemically",
"advantageous",
"sincethe",
"companies",
"are",
"able",
"to",
"invest",
"the",
"capital",
"or",
"pay",
"dividends",
"to",
"their",
"stockholders",
"during",
"the",
"intervening",
"period.",
"Delaying",
"investigation",
"of",
"sources",
"while",
"focusing",
"on",
"ventilation",
"decreases",
"the",
"likelihood",
"that",
"government",
"will",
"authorize",
"regulation",
"of",
"indoor",
"air",
"or",
"provide",
"the",
"funds",
"necessary",
"to",
"investigate",
"adequately",
"indoor",
"pollution",
"sources.",
"Effective",
"IAQ",
"Control",
"Most",
"indoor",
"air",
"quality",
"experts",
"agree",
"that",
"the",
"most",
"effective",
"means",
"of",
"I1AQ",
"control",
"is",
"pollutant",
"source",
"control.",
"Ventilation",
"is",
"essential,",
"but",
"it",
"is",
"only",
"necessary",
"to",
"the",
"extent",
"that",
"source",
"emissions",
"cannot",
"be",
"or",
"are",
"not",
"adequately",
"controlled.",
"Of",
"course",
"there",
"are",
"sources",
"such",
"as",
"occupants",
"and",
"their",
"activities",
"that",
"can",
"only",
"be",
"controlled",
"to",
"a",
"limited",
"extent.",
"And",
"every",
"building",
"is",
"made",
"from",
"materiais",
"that",
".will",
"contribute",
"some",
"level",
"of",
"contamination",
"over",
"the",
"life",
"of",
"the",
"building.",
"Architects",
"and",
"engineers",
"cannot",
"properly",
"design",
"ventilation",
"systems",
"and",
"operators",
"cannot",
"economically",
"and",
"effectively",
"run",
"them",
"without",
"understanding",
"the",
"poliutant",
"sources",
"the",
"HVAC",
"system",
"must",
"contral.",
"An",
"exctusive",
"or",
"dominant",
"focus",
"on",
"ventilation",
"issues",
"distracts",
"building",
"designers,",
"1AQ",
"professionals,",
"legislators.",
"and",
"government",
"officiais",
"from",
"focusing",
"on",
"pollutant",
"sources.",
"Researchers",
"have",
"made",
"enormous",
"strides",
"in",
"identifying",
"the",
"role",
"of",
"sources",
"and",
"in",
"characterizing",
"their",
"emissions.",
"They",
"have",
"recently",
"made",
"progress",
"indevealoping",
"methods",
"toassess",
"the",
"impacts",
"VOC",
"emissions",
"have",
"on",
"building",
"occupants.",
"Butmuch",
"is",
"yet",
"to",
"be",
"done.",
"and",
"it",
"will",
"reguire",
"govemment",
"funding",
"ofbasic",
"research",
"to",
"understand",
"pollutant",
"emissions",
"behaviour",
"and",
"health",
"effects.",
"and",
"to",
"develop",
"more",
"economical",
"ways",
"to",
"test",
"materials.",
"Some",
"building",
"products",
"manufacturers",
"and",
"even",
"whole",
"industries",
"have",
"begunto",
"aggressively",
"seek",
"ways",
"to",
"clean",
"up",
"their",
"products.",
"They",
"find",
"it",
"is",
"in",
"their",
"best",
"interest",
"from",
"both",
"a",
"marketing",
"and",
"a",
"product",
"liability",
"perspective.",
"In",
"most",
"cases,",
"industry-wide",
"standards",
"for",
"testing",
"and",
"for",
"product",
"emissions",
"limits",
"will",
"best",
"serve",
"both",
"the",
"industries",
"and",
"their",
"customers.",
"Ventiiation",
"and",
"Problem",
"‘",
"Buiidings",
"Improving",
"ventilation",
"is",
"aimost",
"always",
"less",
"costly",
"and",
"more",
"productive",
"than",
"conducting",
"the",
"studies",
"necessary",
"todemonstrate",
"the",
"causal",
"relationships",
"between",
"contaminants",
"and",
"occupant",
"responses.",
"Furthermore,",
"in",
"most",
"problem",
"buildings,",
"both",
"owners",
"and",
"occupants",
"are",
"more",
"interested",
"in",
"reducing",
"the",
"effects",
"than",
"in",
"finding",
"the",
"causes.",
"Since",
"it",
"is",
"possible",
"to",
"improve",
"ventilation",
"in",
"nearly",
"every",
"building,",
"whether",
"it",
"has",
"an",
"air",
"quality",
"problem",
"or",
"not,",
"it",
"is",
"almost",
"de",
"rigueur",
"for",
"investigators",
"to",
"recommend",
"improved",
"ventilation.",
"And",
"far",
"nearly",
"every",
"type",
"of",
"indoor",
"air",
"poliutant,",
"increasing",
"ventilation",
"rates",
"and",
"improving",
"ventilation",
"system",
"performance",
"are",
"likely",
"to",
"reduce",
"indoor",
"airborne",
"At",
"the",
"Centre,",
"August",
"1991",
"21",
"1£21£95052"
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"regulation,",
"in",
"connection",
"with",
"his",
"activities",
"on",
"behalf",
"of",
"the",
"Company.",
"The",
"reports",
"must",
"be",
"filed",
"in",
"an",
"accurate",
"and",
"timely",
"manner",
"at",
"the",
"Contractor's",
"expense.",
"Contractor",
"will",
"forward",
"copies",
"of",
"all",
"reports",
"to",
"the",
"Company's",
"Vice",
"President",
"of",
"Corporate",
"Affairs,",
"ijimmediately",
"upon",
"filing.",
"Contractor",
"will",
"provide",
"all",
"necessary",
"information",
"and",
"assistance",
"to",
"the",
"Company",
"in",
"a",
"timely",
"and",
"accurate",
"fashion",
"to",
"enable",
"the",
"Company",
"to",
"comply",
"with",
"its",
"filing",
"and",
"registration",
"obligations.",
"Contractor",
"warrants",
"that",
"it",
"has",
"secured",
"and",
"will",
"maintain",
"all",
"necessary",
"licenses,",
"certifications",
"or",
"registrations",
"required",
"by",
"law.",
"Indemnification",
"Contractor",
"indemnifies",
"and",
"holds",
"harmless",
"the",
"Company",
"and",
"its",
"affiliates",
"and",
"their",
"officers,",
"employees,",
"directors",
"and",
"agents",
"from",
"all",
"claims,",
"liabilities,",
"costs",
"and",
"expenses,",
"including",
"reasonable",
"attorney's",
"fees,",
"that",
"arise",
"f£from,",
"or",
"may",
"be",
"attributable",
"to",
"errcrs,",
"omissions",
"or",
"fault",
"of",
"the",
"Contractor,",
"and",
"which",
"are",
"not",
"caused",
"by",
"the",
"Company.",
"Contractor’s",
"obligation",
"to",
"indemnify",
"and",
"hold",
"harmless",
"will",
"survive",
"the",
"termination",
"cof",
"the",
"Agreement.",
"Independent",
"Contractor",
"Contractor",
"is",
"an",
"independent",
"Contractor",
"and",
"the",
"agreement",
"shall",
"not",
"be",
"construed",
"to",
"create",
"an",
"association,",
"partnership,",
"joint",
"venture,",
"relation",
"of",
"principal",
"and",
"agent",
"or",
"employer",
"and",
"employee",
"between",
"Company",
"and",
"the",
"Contractor",
"or",
"any",
"of",
"his",
"employees",
"within",
"the",
"meaning",
"of",
"any",
"federal,",
"state",
"or",
"local",
"law.",
"Contractor",
"will",
"not",
"enter",
"into",
"any",
"agreement,",
"oral",
"or",
"written,",
"on",
"behalf",
"of",
"the",
"Company",
"or",
"otherwise",
"obligate",
"the",
"Company",
"without",
"the",
"Company's",
"advance",
"written",
"approval.",
"Exclusivity",
"During",
"the",
"term",
"of",
"the",
"Agreement,",
"and",
"for",
"six",
"months",
"thereafter,",
"Contractor",
"will",
"not,",
"without",
"the",
"prior",
"written",
"consent",
"of",
"the",
"Company,",
"engage",
"in",
"lobbying,",
"consulting",
"or",
"similar",
"activities",
"for",
"any",
"company",
"or",
"entity",
"whose",
"business",
"competes",
"with",
"any",
"tobacco",
"product",
"of",
"Company,",
"or",
"the",
"interests",
"of",
"which",
"are",
"adverse",
"to",
"the",
"Company",
".",
"Miscellaneous",
"(a)",
"This",
"Agreement",
"and",
"all",
"matters",
"collateral",
"hereto,",
"shall",
"be",
"governed",
"by",
"the",
"laws",
"of",
"the",
"State",
"of",
"New",
"York",
"applicable",
"to",
"agreements",
"made",
"and",
"to",
"be",
"performed",
"entirely",
"within",
"the",
"State",
"of",
"New",
"York.",
"(b)",
"Contractor",
"shall",
"comply",
"with",
"all",
"applicable",
"laws,",
"regulations,",
"and",
"ordinances",
"relating",
"to",
"his",
"performance",
"of",
"the",
"agreement.",
"Contractor",
"acknowledges",
"that",
"he",
"is",
"cognizant",
"of",
"the",
"provisions",
"of",
"Title",
"13,",
"Section",
"1331,",
"et",
"seq.",
"of",
"the",
"United",
"States",
"Code.",
"{c)",
"This",
"Agreement",
"is",
"the",
"complete",
"agreement",
"between",
"the",
"parties",
"and",
"supersedes",
"any",
"prior",
"oral",
"or",
"written",
"agreement",
"concerning",
"the",
"subject",
"matter.",
"2077456509"
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"Ace",
"Obsier",
"Gynecol",
"Scand",
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"Suppl",
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"1987",
"Beatty",
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"‘",
"Berent",
"J:",
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"between",
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"Q",
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".",
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"Q0,",
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"R,",
"Coble",
"M.",
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"&)-",
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"5.2¢",
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"2:408.41%",
"1068",
"Imarzum1.Y.",
"Nea",
"5,",
"Furusho",
"T,",
"Varatahty",
"and",
"hentabiny",
"of",
"human",
"ferility",
"Ann",
"Hum",
"Genet",
"33-281.2%9,",
"1970",
"Neel",
"IV,",
"Schull",
"W)",
"Differental",
"ferulny",
"and",
"human",
"evolulion,",
"Evolunonary",
"Biolops",
"Vol",
"6.",
"Editct",
"by",
"T",
"Dosthansky.,",
"MK",
"Hecht",
":\\_fg‘",
"Steere",
"New",
"Yori,",
"Appleion-Cenary-Crofis,",
"1972,",
"pp",
"363",
"N",
"e",
"oa",
"w",
"Beony",
"R4,",
"A",
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"study",
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"spermarozoan",
"dimensions",
"1n",
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"selecied",
"for",
"hovs",
"weight",
"Indian",
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1342,
2433,
1415,
2457
],
[
1424,
2435,
1555,
2462
],
[
1487,
2431,
1493,
2467
],
[
1500,
2435,
1555,
2462
],
[
1563,
2440,
1652,
2462
],
[
1663,
2443,
1704,
2463
],
[
1112,
2456,
1130,
2476
],
[
1148,
2457,
1252,
2478
],
[
1265,
2460,
1306,
2482
],
[
1317,
2462,
1377,
2484
],
[
1384,
2463,
1436,
2483
],
[
1449,
2465,
1514,
2485
],
[
1524,
2467,
1553,
2485
],
[
1569,
2470,
1584,
2488
],
[
1592,
2472,
1638,
2489
],
[
1647,
2473,
1709,
2492
],
[
1716,
2473,
1821,
2498
],
[
1829,
2481,
1865,
2494
],
[
1149,
2489,
1187,
2505
],
[
1224,
2491,
1239,
2511
],
[
1251,
2494,
1269,
2506
],
[
1277,
2489,
1306,
2511
],
[
1314,
2495,
1379,
2511
],
[
1396,
2491,
1449,
2512
],
[
1456,
2494,
1510,
2513
],
[
1519,
2495,
1628,
2517
],
[
1639,
2500,
1681,
2518
],
[
1110,
2514,
1128,
2532
],
[
1145,
2513,
1312,
2540
],
[
1331,
2518,
1366,
2538
],
[
1387,
2520,
1462,
2541
],
[
1476,
2528,
1501,
2541
],
[
1513,
2528,
1522,
2543
],
[
1535,
2529,
1572,
2543
],
[
1591,
2529,
1633,
2549
],
[
1647,
2528,
1667,
2546
],
[
1681,
2531,
1855,
2554
],
[
1147,
2544,
1208,
2562
],
[
1216,
2547,
1353,
2570
],
[
1364,
2549,
1416,
2567
],
[
1424,
2550,
1483,
2570
],
[
1491,
2555,
1552,
2571
],
[
1569,
2553,
1624,
2573
],
[
1631,
2555,
1684,
2575
],
[
1693,
2556,
1773,
2578
],
[
1785,
2559,
1828,
2579
],
[
1105,
2569,
1131,
2588
],
[
1144,
2570,
1197,
2590
],
[
1206,
2571,
1229,
2592
],
[
1243,
2572,
1406,
2595
],
[
1414,
2579,
1436,
2596
],
[
1447,
2577,
1589,
2601
],
[
1596,
2583,
1618,
2601
],
[
1626,
2583,
1655,
2604
],
[
1663,
2585,
1793,
2608
],
[
1802,
2594,
1862,
2611
],
[
1144,
2599,
1214,
2619
],
[
1225,
2606,
1245,
2620
],
[
1254,
2602,
1349,
2626
],
[
1361,
2605,
1407,
2623
],
[
1421,
2605,
1429,
2624
],
[
1439,
2605,
1512,
2628
],
[
1520,
2607,
1571,
2627
],
[
1580,
2609,
1724,
2633
],
[
1103,
2625,
1129,
2644
],
[
1142,
2626,
1194,
2647
],
[
1207,
2629,
1231,
2647
],
[
1249,
2631,
1362,
2651
],
[
1374,
2633,
1497,
2658
],
[
1509,
2639,
1613,
2658
],
[
1626,
2642,
1669,
2658
],
[
1683,
2644,
1762,
2665
],
[
1777,
2649,
1796,
2663
],
[
1808,
2645,
1859,
2664
],
[
1144,
2654,
1274,
2675
],
[
1283,
2659,
1303,
2677
],
[
1314,
2660,
1343,
2679
],
[
1352,
2661,
1383,
2678
],
[
1393,
2660,
1521,
2683
],
[
1530,
2665,
1624,
2689
],
[
1633,
2674,
1657,
2686
],
[
1666,
2670,
1742,
2690
],
[
1752,
2670,
1858,
2694
],
[
1142,
2686,
1189,
2703
],
[
1201,
2684,
1237,
2704
],
[
1267,
2692,
1319,
2708
],
[
1333,
2680,
1372,
2715
],
[
1393,
2690,
1494,
2711
],
[
1100,
2708,
1122,
2729
],
[
1139,
2710,
1232,
2731
],
[
1246,
2714,
1266,
2734
],
[
1293,
2715,
1465,
2740
],
[
1476,
2722,
1512,
2738
],
[
1521,
2726,
1582,
2742
],
[
1593,
2725,
1664,
2742
],
[
1685,
2725,
1723,
2745
],
[
1736,
2727,
1826,
2746
],
[
1838,
2730,
1857,
2747
],
[
1141,
2740,
1170,
2758
],
[
1179,
2741,
1335,
2763
],
[
1352,
2745,
1469,
2769
],
[
1481,
2747,
1501,
2766
],
[
1509,
2750,
1535,
2767
],
[
1544,
2749,
1674,
2772
],
[
1683,
2754,
1705,
2776
],
[
1711,
2759,
1807,
2775
],
[
1815,
2757,
1856,
2775
],
[
1611,
2817,
1623,
2867
]
] |
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