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[
"Alan.",
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"and",
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2046807567_7643-38.layout.json
|
[
"11-07/85",
"17:40",
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"Some",
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"in",
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"are",
"a",
"result",
"of",
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"E",
"1S",
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"it",
"1s",
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"SUBJECT",
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507051678_507051691-1.layout.json
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80228906_80228935-19.layout.json
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524860047+-0116-50.layout.json
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"H",
"A.",
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">",
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"140",
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"87",
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"360",
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"72",
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"20",
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"54.",
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"S.",
"G,",
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"N.",
"P,",
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"F.",
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"Corp.,",
"Macon,",
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"31202",
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"microextraction",
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"and",
"GC/MS",
"analysis.",
"The",
"procedure",
"provides",
"a",
"much",
"cleaner",
"chromatogram",
"than",
"on-line",
"pyrolysis",
"and",
"in",
"turn,",
"allows",
"for",
"improved",
"identification",
"of",
"a",
"varicty",
"of",
"compounds",
"in",
"pyralysates.",
"Because",
"the",
"pyrolysis",
"is",
"performed",
"off-line,",
"the",
"analysis",
"of",
"the",
"materials",
"adsorbed",
"on",
"the",
"fiber",
"can",
"be",
"done",
"on",
"any",
"GC/MS",
"system",
"thereby",
"avoiding",
"the",
"need",
"for",
"a",
"dedicated",
"instrument,",
"This",
"expands",
"the",
"possibilitics",
"of",
"using",
"a",
"variety",
"of",
"columns",
"or",
"detection",
"systems",
"for",
"the",
"analysis",
"of",
"pyrolysates.",
"A",
"specific",
"phosphorus/nitrogen",
"detector",
"(NFD)",
"also",
"was",
"evaluated",
"to",
"detect",
"nit-ogenous",
"compounds",
"in",
"pyrolysates.",
"The",
"technique",
"has",
"been",
"used",
"to",
"generate",
"fingerprint",
"chromatograms",
"for",
"different",
"polymeric",
"products",
"such",
"as",
"cellulose,",
"starch,",
"pectin,",
"and",
"to",
"identify",
"trace",
"components",
"in",
"pyrolysatcs,",
"The",
"application",
"of",
"this",
"technique",
"for",
"the",
"analysis",
"of",
"tobacco",
"and",
"tobacco",
"related",
"materials",
"is",
"very",
"promising,",
"52486",
"0097",
"4"
] |
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2022161585_2022161648-31.layout.json
|
[
"III.",
"COMPONENTS",
"METHOD",
"DEVELOPMENT",
"Although",
"we",
"will",
"continue",
"the",
"development",
"of",
"analytical",
"methods",
"for",
"the",
"quantitative",
"and",
"qualitative",
"determination",
"of",
"teobacco",
"components,",
"the",
"number",
"of",
"tobacco",
"constituents",
"have",
"been",
"reduced",
"and",
"prioritized.",
"Priority",
"status",
"was",
"based",
"on",
"present",
"needs",
"(i.e.",
"on-going",
"projects)",
"and",
"estimates",
"of",
"future",
"activities.",
"Thus",
"we",
"will",
"concentrate",
"on",
"the",
"tobacco",
"amino",
"acids",
"(aging",
"studies),",
"the",
"organic",
"acids",
"(flavor",
"response),",
"and",
"maleic",
"hydrazide",
"{economic",
"significance).",
"Additionally,",
"special",
"tobacco",
"processing",
"steps",
"have",
"required",
"better",
"methods",
"to",
"be",
"developed",
"for",
"urea",
"and",
"sorbic",
"acid,",
"and",
"on-line",
"nitrate",
"in",
"extracts.",
"IV.",
"PYROLYSIS",
"AND",
"COMBUSTION",
"OF",
"TOBACCO",
"Our",
"interest",
"in",
"understanding",
"the",
"mechanism(s)",
"of",
"tobacco",
"thermal",
"degradation",
"in",
"hopes",
"of",
"controlling",
"the",
"decomposition",
"process",
"will",
"continue",
"in",
"1981.",
"The",
"addition",
"of",
"a",
"new",
"FT-IR",
"System",
"will",
"permit",
"the",
"studies",
"to",
"be",
"completed",
"more",
"accurately",
"and",
"efficiently.",
"In",
"addition",
"to",
"studying",
"the",
"effects",
"of",
"tobacco",
"processing",
"by",
"monitoring",
"the",
"changes",
"in",
"gases",
"evolved",
"during",
"a",
"controlled",
"temperature",
"profile,",
"the",
"data",
"generated",
"with",
"the",
"new",
"System",
"will",
"be",
"used",
"to",
"formulate",
"models",
"for",
"tobacco",
"decomposition.",
"V.",
"CIGARETTEvSMOKE",
"STUDIES",
"The",
"Analytical",
"Research",
"Division",
"will",
"actively",
"participate",
"in",
"three",
"major",
"cigarette",
"smoke",
"studies:",
"(1)",
"the",
"completion",
"and",
"refinement",
"of",
"the",
"fluorescent",
"method",
"for",
"measuring",
"FTC",
"tar,",
"(2)",
"establish",
"the",
"NO.",
"levels",
"in",
"the",
"environment",
"and",
"determine",
"the",
"contribution",
"from",
"cigarette",
"smoke,",
"and",
"(3)",
"monitor",
"gas",
"phase",
"components",
"on",
"both",
"a",
"puff",
"by",
"puff",
"basis",
"and",
"single",
"puff",
"profiling.",
"VI.",
"FILTER",
"DILUTION",
"The",
"Diode",
"Laser",
"system",
"will",
"be",
"used",
"to",
"develop",
"a",
"procedure",
"to",
"measure",
"changes",
"in",
"filter",
"dilution",
"under",
"dynamic",
"conditions.",
"This",
"type",
"of",
"information",
"will",
"greatly",
"facilitate",
"our",
"understanding",
"the",
"mechanism",
"of",
"dilution.",
"_",
"/;/@.",
"93191912202"
] |
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2046807567_7643-20.layout.json
|
[
"[",
"=",
"12",
"10",
"o",
"I",
"<",
"<",
"PHILIP",
"MORRIS",
"CO",
"CRS-20",
"ETS",
"AND",
"LUNG",
"CANCER",
"EPIDEMIOLOGY",
"INTRODUCTION",
"This",
"section",
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"a",
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"of",
"the",
"epidemiological",
"evidence",
"for",
"the",
"possible",
"relationship",
"between",
"ETS",
"and",
"lung",
"cancer,",
"based",
"on",
"results",
"for",
"spousal",
"expasure.",
"The",
"review",
"will",
"particularly",
"address",
"the",
"dose-response",
"relationship",
"between",
"ETS",
"exposure",
"and",
"lung",
"cancer",
"risk",
"reported",
"in",
"many",
"of",
"these",
"studies.",
"Results",
"of",
"these",
"studies",
"will",
"be",
"presented",
"first,",
"followed",
"by",
"a",
"diseussion",
"of",
"the",
"with",
"snalyses.",
"The",
"section",
"will",
"conclude",
"with",
"&",
"discussion",
"of",
"the",
"principal",
"sourzes",
"of",
"possible",
"alternative",
"explanations",
"of",
"the",
"results",
"given",
"in",
"the",
"studies.",
"Primary",
"atiention",
"is",
"given",
"to",
"confounders,",
"misclassifications",
"and",
"recall",
"errczs.",
"BACKGROUND",
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"similarities",
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"mainstream",
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"sidestream",
"smeke",
"and",
"the",
"association",
"of",
"active",
"smokizg",
"with",
"lung",
"cancer",
"are",
"reasons",
"for",
"a",
"possible",
"relationship",
"between",
"ETS",
"ané",
"lung",
"camcer.",
"But,",
"they",
"do",
"not",
"prove",
"the",
"relationship,",
"since",
"ETS",
"is",
"substzotially",
"diluted",
"and",
"aged",
"compared",
"o",
"even",
"low",
"levels",
"B",
"active",
"SmoKImE,.",
"it",
"18",
"possible",
"that",
"ETS",
"exposures",
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"too",
"small",
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"tHevause",
"of",
"{Ufg",
"cancer",
"I",
"acy",
"meaningful",
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";__it",
"is",
"possible",
"that",
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"expOsUTEs",
"are",
"arge",
"erHough",
"To",
"Dave",
"en",
"effect",
"ang",
"others",
"are",
"not;",
"and,",
"it",
"is",
"fifimfimfimmuld",
"cause",
"some",
"disease.",
"@o021/033",
"Epidemiologic",
"studies",
"are",
"statistical",
"studies",
"of",
"actual",
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"that",
"are",
"aimed",
"at",
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"these",
"questions.",
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"use",
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"a",
"measure",
"of",
"exposura",
"to",
"ETS,",
"marriage",
"to",
"a",
"smoker.",
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"a",
"couple",
"of",
"exceptions,",
"these",
"studies",
"are",
"of",
"the",
"\"case-controi”",
"type.",
"A",
"group",
"of",
"non-smoking",
"women",
"ill",
"with",
"lung",
"cancer",
"(cases)",
"are",
"questioned",
"as",
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"the",
"smoking",
"status",
"of",
"their",
"husbands",
"and",
"a",
"comparable",
"group",
"from",
"the",
"population",
"at",
"large",
"(controls)",
"are",
"also",
"questioned.",
"If",
"a",
"larger",
"fraction",
"of",
"the",
"cages",
"have",
"been",
"exposed",
"than",
"cf",
"the",
"controls,",
"the",
"risk",
"of",
"ETS",
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"positive.",
"The",
"risk",
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"usually",
"expressed",
"as",
"arelative",
"risk",
"ratio",
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"odds",
"ratio),",
"which",
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"the",
"ratio",
"of",
"exposed",
"to",
"unexposed",
"amo",
"e",
"cases,",
"divided",
"by",
"the",
"ratio",
"of",
"exposed",
"to",
"unexposed",
"among",
"the",
"controls.",
"If",
"the",
"risk",
"ratio",
"is,",
"for",
"example,",
"1.2,",
"that",
"means",
"that",
"exposure",
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"ETS",
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"risk",
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"lung",
"cancer",
"by",
"twenty",
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"{Such",
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"risk",
"would",
"be",
"quite",
"small",
"in",
"absolut",
"wever,",
"because",
"lung",
"cancer",
"AT00Ng",
"NONSTHOKETS",
"s",
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"MONg",
"NONSIMORers",
"F",
"4",
"=~",
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"2",
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"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIEUTION.",
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] |
508939370_508939517-47.layout.json
|
[
"41",
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2063597106_2063597113-1.layout.json
|
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"Cobb,",
"DeKalb,",
"Ful-",
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"Orleans,",
"La",
"(Jefferson,",
"Orleans,",
"and",
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"Bernard",
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"Los",
"Angeles,",
"Calif",
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"Ange-",
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"the",
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"Francisco",
"Bay",
"Area,",
"Calif",
"(Alameda,",
"Contra",
"Costa,",
"Marin,",
"San",
"Franecisco,",
"San",
"Mateo,",
"and",
"Santa",
"Clara",
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"Additional",
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"A",
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"language,",
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"use",
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"79",
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"code",
"153)",
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"frequency",
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"series",
"by",
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"group",
"and",
"race.",
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"group",
"was",
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"bias",
"associated",
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"for",
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"using",
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"the",
"study",
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"into",
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"2",
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"was",
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"from",
"the",
"po-",
"tential",
"study",
"subject",
"or",
"her",
"next",
"of",
"kin",
"for",
"those",
"patients",
"whose",
"medical",
"records",
"and",
"physicians",
"did",
"not",
"indicate",
"a",
"history",
"of",
"smoking.",
"The",
"telephone",
"screening",
"pro-",
"cedure",
"(tier",
")",
"was",
"also",
"used",
"to",
"determine",
"lifetime",
"tobacco",
"use",
"of",
"the",
"population",
"con-",
"trol",
"group.",
"At",
"the",
"interview,",
"the",
"tobacco",
"use",
"screening",
"questions",
"were",
"repeated",
"to",
"confirm",
"each",
"study",
"subject’s",
"reported",
"status",
"as",
"a",
"lifetime",
"nonuser",
"of",
"tobacco.",
"JAMA,",
"June",
"8,",
"1994—Vol",
"271,",
"No.",
"22",
"Q",
"Ofthe",
"17447",
"potential",
"cases",
"ascertained",
"in",
"the",
"five",
"study",
"centers,",
"800",
"were",
"found",
"to",
"meet",
"all",
"eligibility",
"criteria.",
"In-person",
"interviews",
"were",
"completed",
"for",
"665",
"(83%)",
"of",
"800",
"incident",
"cases",
"and",
"1278",
"(70%)",
"of",
"1826",
"population",
"controls.",
"An",
"interview",
"was",
"solicited",
"from",
"the",
"next",
"of",
"kin",
"of",
"cases",
"who",
"were",
"deceased",
"or",
"were",
"too",
"ill",
"to",
"par-",
"ticipate",
"in",
"an",
"interview.",
"Information",
"for",
"241",
"lung",
"cancer",
"cases",
"(36%)",
"was",
"obtained",
"from",
"next-of-kin",
"respondents.",
"At",
"interview,",
"a",
"urine",
"sample",
"was",
"col-",
"Jected",
"from",
"all",
"consenting",
"study",
"subjects",
"who",
"were",
"able",
"to",
"provide",
"such",
"a",
"sample.",
"Urinary",
"cotinine",
"and",
"creatinine",
"were",
"de-",
"termined",
"and",
"the",
"ratio",
"used",
"as",
"an",
"indi-",
"cator",
"of",
"current",
"smoking",
"status.",
"The",
"re-",
"quest",
"for",
"the",
"sample",
"was",
"not",
"made",
"until",
"the",
"interview.",
"Specimens",
"were",
"stored",
"at",
"—20°C",
"until",
"analysis",
"at",
"the",
"American",
"Health",
"Foundation,",
"Valhalla,",
"NY.",
"Cotinine",
"was",
"quantitated",
"by",
"radioim-",
"munoassay",
"using",
"the",
"method",
"of",
"Haley",
"et",
"al*",
"with",
"a",
"modification",
"of",
"the",
"antibody",
"of",
"Langone",
"et",
"al®",
"Cotinine",
"concentrations",
"were",
"adjusted",
"for",
"urine",
"flow",
"based",
"on",
"creatinine",
"values",
"by",
"determining",
"the",
"nanograms",
"of",
"cotinine",
"per",
"milligrams",
"of",
"creatinine.",
"Creatinine",
"was",
"determined",
"by",
"spectrophotometry",
"using",
"the",
"Kodak",
"Ek-",
"tachem",
"400",
"Clinical",
"Chemistry",
"Analyzer",
"(Kodak,",
"Rochester,",
"NY).",
"Urine",
"samples",
"were",
"analyzed",
"for",
"356",
"(53.5%)",
"of",
"665",
"cases",
"and",
"1064",
"(83.3%)",
"of",
"1278",
"controls.",
"The",
"difference",
"in",
"the",
"pro-",
"portions",
"of",
"cases",
"and",
"controls",
"is",
"attrib-",
"utable",
"to",
"deceased",
"cases.",
"A",
"high",
"propor-",
"tion",
"of",
"living",
"study",
"subjects",
"were",
"able",
"and",
"willing",
"to",
"provide",
"a",
"urine",
"sample,",
"and",
"the",
"proportions",
"were",
"similar",
"for",
"cases",
"(81.1%)",
"and",
"controls",
"(83.3%)",
"despite",
"dif-",
"ferences",
"in",
"health",
"status.",
"As",
"in",
"the",
"origi-",
"nal",
"report,",
"subjects",
"in",
"the",
"case",
"and",
"con-",
"trol",
"groups",
"whose",
"cotinine/creatinine",
"con-",
"centration",
"exceeded",
"100",
"ng/mg",
"were",
"ex-",
"cluded",
"from",
"the",
"study",
"to",
"eliminate",
"persons",
"likely",
"to",
"be",
"active",
"smokers.?2",
"Two",
"(0.6%)",
"of",
"856",
"cases",
"and",
"25",
"(2.3%)",
"of",
"1064",
"controls",
"had",
"cotinine/creatinine",
"concentrations",
"of",
"100",
"ng/mg",
"or",
"higher.",
"Although",
"no",
"opti-",
"mum",
"concentration",
"has",
"been",
"established",
"as",
"a",
"cut",
"point",
"for",
"distinguishing",
"true",
"non-",
"smokers",
"from",
"smokers",
"in",
"studies",
"that",
"are",
"restricted",
"to",
"women",
"and",
"include",
"subjects",
"with",
"cancer,",
"a",
"concentration",
"of",
"50",
"ng/mg",
"or",
"lower",
"has",
"been",
"used",
"as",
"the",
"eligibility",
"criterion",
"in",
"a",
"large",
"study",
"of",
"healthy,",
"free-",
"living",
"subjects,®",
"and",
"others",
"have",
"been",
"suggested.’™",
"In",
"high-exposure",
"settings,",
"urinary",
"cotinine",
"in",
"nonsmokers",
"has",
"reached",
"a",
"concentration",
"of",
"55",
"ng/mg",
"of",
"cotinine/ereatinine.®®*",
"In",
"this",
"study,",
"nine",
"cases",
"(2.5%)",
"and",
"29",
"controls",
"(2.7%)",
"had",
"urinary",
"concentrations",
"of",
"55",
"to",
"99",
"ng/mg.",
"Analyses",
"of",
"ETS-related",
"risk",
"estimates",
"were",
"also",
"conducted",
"using",
"a",
"cut",
"point",
"of",
"55",
"ng/mg",
"of",
"cotinine/creatinine",
"as",
"an",
"ex-",
"clusion",
"criterion",
"to",
"evaluate",
"the",
"possibil-",
"ity",
"that",
"the",
"study",
"findings",
"were",
"biased",
"as",
"aresult",
"ofinclusion",
"of",
"study",
"subjects",
"with",
"borderline",
"concentrations",
"(55",
"to",
"99",
"ng/",
"mg)",
"of",
"cotinine/creatinine.",
"Representative",
"diagnostic",
"specimen",
"slides",
"for",
"each",
"case",
"were",
"requested",
"from",
"the",
"hospital",
"for",
"review",
"by",
"one",
"pathologist",
"specializing",
"in",
"pulmonary",
"pathology.",
"A",
"total",
"of",
"562",
"(85%)",
"of",
"663",
"potential",
"cases",
"had",
"diagnostic",
"material",
"available",
"for",
"re-",
"view,",
"and",
"552",
"(98%)",
"of",
"the",
"reviewed",
"cases",
"were",
"confirmed",
"as",
"primary",
"bronchogenic",
"carcinoma.",
"After",
"exclusion",
"of",
"the",
"10",
"cases",
"that",
"had",
"review",
"diagnoses",
"inconsistent",
"with",
"primary",
"bronchogenic",
"carcinoma,",
"the",
"final",
"interviewed",
"case",
"series",
"included",
"653",
"lung",
"cancer",
"cases:",
"497",
"adenocarcinomas",
"(76.1%);",
"74",
"large-cell",
"carcinomas",
"(11.3%);",
"40",
"squamous",
"cell",
"carcinomas",
"(6.1%);",
"24",
"small-cell",
"carcinomas",
"(3.7%);",
"and",
"18",
"other",
"primary",
"lung",
"carcinomas",
"(2.8%).",
"The",
"101",
"cases",
"with",
"diagnostic",
"slides",
"that",
"were",
"un-",
"available",
"for",
"review",
"were",
"classified",
"ac-",
"cording",
"to",
"the",
"original",
"hospital",
"and",
"tumor",
"registry",
"diagnosis.",
"The",
"distribution",
"by",
"cell",
"type",
"was",
"similar",
"for",
"the",
"reviewed",
"and",
"nonreviewed",
"cases",
"except",
"for",
"a",
"higher",
"proportion",
"of",
"cases",
"in",
"the",
"“other",
"primary",
"lung",
"carcinomas”",
"category",
"among",
"non-",
"reviewed",
"cases.",
"Analyses",
"of",
"ETS-related",
"risk",
"estimates",
"were",
"also",
"conducted",
"ex-",
"cluding",
"cases",
"that",
"did",
"not",
"undergo",
"inde-",
"pendent",
"review",
"to",
"evaluate",
"consistency",
"of",
"the",
"findings.",
"In-person",
"interviews",
"followed",
"an",
"ex-",
"tensive",
"structured",
"questionnaire",
"designed",
"to",
"obtain",
"information",
"on",
"household,",
"oc-",
"cupational,",
"and",
"other",
"exposures",
"to",
"ETS",
"during",
"each",
"study",
"subject’s",
"lifetime,",
"as",
"well",
"as",
"other",
"exposures",
"associated",
"with",
"lung",
"cancer.",
"Exposure",
"to",
"ETS",
"was",
"ex-",
"amined",
"by",
"source",
"during",
"childhood",
"(fa-",
"ther,",
"mother,",
"and",
"other",
"household",
"mem-",
"bers",
"who",
"lived",
"in",
"the",
"home",
"for",
"at",
"least",
"6",
"months)",
"and",
"during",
"adult",
"life",
"(spouse,",
"other",
"household",
"members,",
"occupational,",
"and",
"social",
"exposures).",
"Childhood",
"included",
"the",
"years",
"from",
"birth",
"through",
"age",
"18",
"years.",
"Exposures",
"from",
"parents",
"after",
"that",
"time",
"were",
"classified",
"as",
"other",
"household",
"mem-",
"bers",
"during",
"adult",
"life.",
"Dichotomous",
"ETS",
"exposure",
"(ever",
"or",
"never)",
"was",
"examined",
"by",
"source",
"and",
"type",
"of",
"tobacco.",
"Pack-years",
"of",
"cigarette",
"smoke",
"exposure",
"from",
"spouse",
"were",
"calculated",
"by",
"multiplying",
"the",
"num-",
"ber",
"of",
"packs",
"smoked",
"per",
"day",
"by",
"the",
"num-",
"ber",
"of",
"years",
"the",
"spouse",
"smoked",
"cigarettes",
"while",
"living",
"with",
"the",
"study",
"subject.",
"Du-",
"ration",
"of",
"exposure",
"by",
"source",
"was",
"mea-",
"sured",
"in",
"years.",
"Years",
"of",
"exposure",
"in",
"oc-",
"cupational",
"settings",
"represent",
"the",
"sum",
"of",
"years",
"of",
"employment",
"in",
"each",
"job",
"in",
"which",
"persons",
"were",
"reported",
"to",
"have",
"smoked",
"around",
"the",
"study",
"subject.",
"Years",
"of",
"ex-",
"posure",
"from",
"individual",
"sources",
"were",
"ex-",
"amined,",
"and",
"a",
"summary",
"measure",
"(smoke-",
"years)",
"of",
"exposure",
"during",
"childhood",
"and",
"adult",
"life",
"was",
"calculated.",
"Smoke-years",
"Tobacco",
"Smoke",
"and",
"Lung",
"Cancer—Fontham",
"et",
"al",
"1753",
"LOTL65EF0Z"
] |
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566,
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631,
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627,
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494,
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621,
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638,
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708,
463,
742,
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758,
465,
888,
497
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251,
505,
403,
540
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417,
505,
474,
533
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486,
504,
619,
540
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632,
505,
706,
533
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715,
506,
781,
537
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793,
509,
889,
545
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[
251,
545,
292,
572
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308,
545,
445,
580
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460,
545,
516,
573
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530,
545,
579,
572
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593,
545,
650,
573
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663,
546,
811,
576
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826,
550,
890,
585
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251,
585,
338,
620
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369,
585,
446,
616
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472,
585,
628,
622
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657,
586,
764,
617
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792,
589,
888,
627
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[
251,
629,
354,
662
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376,
629,
434,
658
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455,
629,
613,
664
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[
633,
629,
690,
658
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[
709,
630,
812,
667
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832,
634,
888,
662
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251,
670,
343,
699
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353,
670,
439,
699
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448,
671,
595,
703
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604,
671,
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701
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672,
889,
710
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[
251,
712,
294,
747
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[
308,
713,
425,
741
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[
437,
711,
568,
741
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[
581,
721,
633,
748
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[
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713,
830,
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844,
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749
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[
252,
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282,
782
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[
294,
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328,
782
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[
339,
755,
448,
790
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[
459,
754,
599,
790
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611,
754,
748,
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793
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253,
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286,
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304,
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829
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469,
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627,
823
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253,
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627,
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[
254,
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290,
1027
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[
296,
1000,
478,
1036
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[
485,
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667,
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[
672,
1001,
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1029
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[
781,
1001,
892,
1030
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[
292,
1041,
320,
1069
],
[
332,
1040,
599,
1077
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[
612,
1042,
718,
1070
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[
729,
1050,
819,
1078
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[
831,
1052,
891,
1071
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[
254,
1082,
383,
1111
],
[
408,
1082,
448,
1118
],
[
471,
1081,
592,
1111
],
[
615,
1081,
685,
1118
],
[
708,
1082,
812,
1119
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[
835,
1084,
892,
1112
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0060132598-3.layout.json
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524860047+-0116-45.layout.json
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[
"Science",
"Research",
"Conference",
"—",
"State",
"of",
"The",
"Business",
"2000",
"10:55",
"Am",
"TUEsDAY",
"44,",
"GENDER",
"DIFFERENCES",
"IN",
"LEVELS",
"OF",
"URINARY",
"BIOMARKERS",
"OF",
"EXPOSURE",
"TO",
"NICOTINE",
"AND",
"CARCINOGENS",
"IN",
"CIGAREI'TE",
"SMOKE.",
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"V.",
"Djordjevic,",
"Steven",
"D.",
"Stellman,",
"Harry",
"Anagnostopoulos,",
"and",
"John",
"P,",
"Richie,",
"Jr.",
"American",
"Health",
"Foundation,",
"Valhalla,",
"NY",
"10595",
"An",
"estimated",
"90.3%",
"of",
"lung",
"cancer",
"deaths",
"in",
"men",
"and",
"78.5%",
"of",
"those",
"in",
"women",
"are",
"attributable",
"to",
"cigarctte",
"smoking.",
"The",
"relative",
"risk",
"for",
"threc",
"major",
"histologic",
"lung",
"cancer",
"types",
"has",
"been",
"shown",
"to",
"be",
"consistently",
"higher",
"for",
"women",
"compared",
"to",
"men",
"at",
"every",
"level",
"of",
"exposure",
"to",
"cigarette",
"smoke",
"suggesting",
"gender",
"differences",
"in",
"metabolism",
"of",
"nicotine",
"and",
"lung-specific",
"carcinogens.",
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"behavior,",
"delivered",
"dosages",
"of",
"nicotine",
"and",
"lung",
"adenocarcinoma-inducing",
"tobacco-specific",
"‘",
"nitrosamine",
"NNK,",
"as",
"well",
"as",
"urinary",
"levels",
"of",
"their",
"principal",
"metabolites",
"were",
"determined",
"for",
"€8",
"female",
"and",
"62",
"male",
"smokers",
"of",
"American",
"blend",
"cigarettes.",
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"and",
"female",
"smokers",
"of",
"both",
"low-yield",
"(<",
"8",
"mg",
"FIC-nicotine/cigt.)",
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"medium-yield",
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"similar",
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"of",
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"tar,",
"and",
"NNK",
"daily.",
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"the",
"levels",
"of",
"urinary",
"cotinine",
"and",
"NNAL,",
"adjusted",
"E",
"for",
"creatinine",
"and",
"number",
"of",
"cigarettes",
"per",
"day,",
"were",
"significantly",
"higher",
"(p<0.01)",
"among",
"viomen.",
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"was",
"further",
"enhanced",
"when",
"the",
"biomarker",
"1",
"levels",
"were",
"adjusted",
"for",
"daily",
"intake",
"of",
"nicotine",
"and",
"NNK",
"(p<0.001).",
"It",
"is",
"noteworthy",
"E",
"that",
"levels",
"of",
"biomarkers",
"did",
"not",
"differ",
"significantly",
"among",
"smokers",
"of",
"low-",
"and",
"medium-yicld",
"cigarettes,",
"whether",
"male",
"or",
"female.",
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"findings",
"suggest",
"that",
"gender",
"differences",
"in",
"risk",
"of",
"lung",
"cancer",
"cannot",
"be",
"explained",
"by",
"differences",
"in",
"base-line",
"exposure,",
"smoking",
"history",
"or",
"body",
"size,",
"but",
"may",
"be",
"due",
"in",
"part",
"to",
"higher",
"susceptibility",
"to",
"tobacco",
"carcinogens",
"in",
"women.",
"11:15",
"aM",
"TUESDAY",
"45.",
"BIOLOGICAL",
"STUDIES",
"ON",
"SMOKE",
"CONDENSATES",
"FROM",
"CIGAREITES",
"MADE",
"WITH",
"LOW",
"NITROSAMINE",
"FLUE-CURED",
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").",
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"B.",
"R,",
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"K.",
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"ID.",
"W,",
"Bombick,",
"T.",
"B.",
"Nestor,",
"].",
"§.",
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"R.].",
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"Winston-Salem,",
"NG",
"27102",
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"in",
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"lower",
"concentrations",
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"of",
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"for",
"heating",
"the",
"air",
"in",
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"evatuate",
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"potential",
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"smoke",
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"from",
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"with",
"tobacco",
"cured",
"using",
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"direct-fired",
"curing",
"or",
"heat",
"exchange",
"curing.",
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"Ames",
"test",
"was",
"used",
"to",
"evaluate",
"genotoxicity,",
"and",
"the",
"Neutral",
"Red",
"assay",
"was",
"used",
"to",
"cytotoxicity.",
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"smoke",
"condensates",
"were",
"mutagenic",
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85282772_2776-1.layout.json
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[
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524860047+-0116-12.layout.json
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"metabolized",
"by",
"these",
"enzymes,",
"e.g.",
"alkyl",
"halides,",
"aromatic",
"hydrocarbons,",
"The",
"Cytochraues",
"P-430",
"are",
"a",
"group",
"of",
"hemoproteins",
"which",
"are",
"associated",
"with",
"the",
"aicrosomal",
"aor",
"lipid",
"portion",
"of",
"a",
"cell.",
"Their",
"designation",
"as",
"P-450",
"complex",
"at",
"430",
"nm",
"in",
"a",
"difference",
"spectrum",
"(Omura",
"&",
"Sato,",
"1964).",
"These",
":",
":",
"hemoproteins",
"also",
"have",
"enzysic",
"activity,",
"and",
"can",
"metabolize",
"relatively",
"lxpophxlxc:f",
"normal",
"function",
"of",
"the",
"body",
"and",
"result",
"in",
"the",
"formation",
"of",
"many",
"impartant",
"'",
"hormanes.",
"A",
"great",
"variety",
"of",
"non-physiologic",
"compounds",
"(xenobiotics)",
"can",
"aliphatic",
"amines,",
"etc.",
"Such",
"broad",
"substrate",
"specificity",
"is",
"enhanced",
"by",
"the",
"fact",
"that",
"the",
"relative",
"population",
"of",
"isaozymes",
"can",
"be",
"altered",
"by",
"the",
"presence",
"of",
"a",
"potential",
"substrate.",
"Such",
"alterations",
"may",
"increase",
"the",
"amcunt",
"of",
"only",
"one",
"specific",
"isczyme",
"that",
"metabolizes",
"that",
"substrate,",
"or",
"all",
"P-450",
"activity",
"can",
"be",
"increased",
"umriformly.",
"In",
"either",
"case,",
"the",
"phenomenon",
"of",
"induction",
"can",
"have",
"important",
"consequences",
"not",
"only",
"to",
"the",
"xenobiotic",
"substrate'fi'a",
"that",
"induced",
"the",
"activity,",
"but",
"alsoc",
"to",
"physiclogic",
"substrates.",
"Draft",
"Report",
"[-5026.401",
"I[I.",
"INTRODUCTION",
"0f",
"the",
"number",
"of",
"compounds",
"that",
"have",
"been",
"shown",
"to",
"induce",
"P-4350,",
"most",
"have",
"tended",
"to",
"fall",
"into",
"one",
"of",
"two",
"categories",
"based",
"on",
"their",
"similarity",
"to",
"two",
"classic",
"inducers:",
"phenobarbital",
"and",
"methylcholanthrene",
"{(Snyder",
"and",
"Remmer,",
"1979).",
"Phencbarbital",
"(PB)",
"induces",
"general",
"P-450",
"activity,",
"while",
"methylcholanthrene",
"(MC)",
"induces",
"a",
"different",
"type",
"of",
"P-450",
"called",
"P;-450",
"or",
"P-448,",
"named",
"because",
"of",
"the",
"shift",
"in",
"spectral",
"maximum",
"from",
"450",
"to",
"448",
"o",
"Both",
"MC",
"and",
"PB",
"induced",
"forms",
"of",
"P-4350",
"can",
"be",
"induced",
"By",
"certain",
"chlorinated",
"biphenyls",
"such",
"as",
"Aroclor",
"1234",
"(Parkinson",
"et",
"al.,",
"1983).",
"A",
"number",
"of",
"reactions",
"have",
"been",
"used",
"to",
"assay",
"P-430",
"activity.",
"Three",
"primary",
"assays",
"can",
"be",
"enployed",
"to",
"examine",
"P-450",
"and",
"P-448",
"activity",
"£}",
"p-Nxtroanxsole",
"O-demethylation",
"The",
"demethylatxon",
"of",
"p-n:troan1sole'",
"has",
"been",
"used",
"as",
"a",
"marker",
"for",
"P-450",
"activity",
"in",
"the",
"liver",
"(Thurman",
".",
"et",
"al.,",
"1977).",
"w",
"2)",
"7-Ethoxycoumarin",
"O-deethylation",
"The",
"0O-deethylation",
"of",
"7EC",
"3",
"has",
"been",
"shown",
"toc",
"be",
"a",
"sensitive",
"marker",
"for",
"P-448",
"and",
"P-450",
"1nductton",
"‘",
"{6reenlee",
"and",
"Peland,",
"1978).",
"3)",
"Ethoxyresorufin",
"O-deethylation",
"Ethoxyrescrufin",
"deethylation",
"is",
"a",
"sensitive",
"marker",
"for",
"P-448",
"induction",
"in",
"rat",
"liver,",
"kidneys,",
"_",
"a;",
"and",
"lungs",
"(Nims",
"et",
"al.,",
"1984).",
"*",
"I",
"@",
"3",
"S",
">",
"3",
"b",
"3"
] |
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509790579+-0598-13.layout.json
|
[
"USA",
"REPORT",
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"bacteria",
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"inspectors,",
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"zero",
"tolerance",
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"an",
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"m",
"1990",
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"NTERNATIONAL",
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"reguiators",
"have",
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"pesticide",
"treatment",
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"not",
"present",
"a",
"health",
"hazard.",
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"lawyers",
"for",
"the",
"plaintiffs",
"contend",
"the",
"company",
"breached",
"s",
"warranty",
"by",
"not",
"disctosing",
"the",
"contents",
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"the",
"packages.",
"despite",
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"fact",
"that",
"the",
"mislabelling",
"had",
"been",
"unintenuonal",
"“The",
"fact",
"that",
"no",
"one",
"has",
"been",
"harmed",
"at",
"this",
"point",
"isn't",
"important”.",
"said",
"Clinton",
"Kristor.",
"attorney",
"for",
"the",
"consumers’",
"graups.",
"\"Peoplc",
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"very",
"concerned",
"about",
"what",
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"children",
"cat.",
"and",
"the",
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"all",
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"were",
"sold",
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"the",
"sub-",
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"4E,",
"which",
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"as",
"the",
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"for",
"treating",
"their",
"oa",
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"approved",
"for",
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"Retdan",
"4E.",
"is",
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"the",
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"Agency",
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"of",
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"for",
"all",
"purchases",
"of",
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"10",
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"1993,",
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"i",
"T",
"1994",
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"dondon:",
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"EC",
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"Law",
":",
"September",
"1994",
"ul",
"Y",
"o",
"~J",
"0",
"@",
"ul",
")",
"N"
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505499067_505499073-0.layout.json
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0011977758-9.layout.json
|
[
"ACTIVITY:",
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"USA",
"MAJOR",
"MARKETING",
"DECISION",
"RECOMMENDATION",
"Various",
"PRODUCT(S):",
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"V.",
"PROBLEM/CPPORTUNITY",
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"ANALYSIS",
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[
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[
"Department",
"of",
"Justice",
"Washingion,",
"DC.",
"20530",
"April",
"4,",
"1995",
"Diane",
"Killoxry",
"Morrison",
"&",
"Foerster",
"2000",
"Pennsylvania",
"Ave.",
"D.C.",
"20006-1888",
"Re:",
"Madisop",
"Square",
"Gaxden,",
"L.P.",
"pear",
"Ms.",
"Killory:",
"This",
"letter",
"is",
"being",
"furnished",
"to",
"you",
"at",
"your",
"request",
"and",
"pursuant",
"to",
"discussions",
"you",
"have",
"had",
"with",
"Brian",
"N.",
"Eisen,",
"a",
"trial",
"in",
"this",
"office.",
"According",
"to",
"Mzr.",
"Eisen,",
"you",
"seek",
"a",
"written",
"statement",
"of",
"the",
"Department’s",
"views",
"concerning",
"certain",
"language",
"in",
"the",
"Consent",
"Decree",
"between",
"the",
"United",
"and",
"your",
"client,",
"Madison",
"Square",
"Garden,",
"L.P.,",
"that",
"was",
"filed",
"earlier",
"today.",
"specifically,",
"you",
"seek",
"a",
"representation",
"from",
"the",
"Department",
"that",
"it",
"does",
"not",
"consider",
"the",
"center-hung",
"scoreboard",
"at",
"Madison",
"Square",
"Garden",
"to",
"be",
"a",
"location",
"that",
"is",
"in",
"a",
"camera‘’s",
"focus\"",
"during",
"the",
"telecast",
"of",
"basketball",
"games,",
"as",
"that",
"phrase",
"is",
"used",
"in",
"paragraph",
"S(b}",
"of",
"the",
"Consent",
"Decree.",
"You",
"also",
"have",
"requested",
"a",
"statement",
"concerning",
"the",
"Department’s",
"present",
"enforcement",
"incention",
"relating",
"to",
"the",
"potential",
"post-Decrae",
"relecast",
"of",
"excerpts",
"or",
"wclips\"",
"of",
"past",
"arena",
"events",
"at",
"which",
"cigarette",
"signage",
"was",
"displayed.",
"You",
"have",
"provided",
"us",
"with",
"videotapes",
"of",
"the",
"following",
"two",
"games",
"played",
"at",
"Madisen",
"Square",
"Garden:",
"(1)",
"New",
"York",
"Knicks",
"vs.",
"Indiana",
"Pacers,",
"June",
"1,",
"1994",
"(broadcast",
"by",
"NBC):",
"and",
"{2)",
"New",
"York",
"Knicks",
"vs.",
"Miami",
"Heat,",
"pecember",
"12,",
"1994",
"{broadcast",
"by",
"MSGN)",
".",
"Each",
"tape",
"was",
"represented",
"to",
"be,",
"and",
"appears",
"to",
"be,",
"an",
"\"as",
"broadcasat”",
"tape;",
"that",
"is,",
"a",
"tape",
"of",
"the",
"broadcast,",
"including",
"commercials,",
"as",
"it",
"was",
"seen",
"by",
"the",
"game’'s",
"television",
"audience.",
"We",
"have",
"reviewed",
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71501255-1.layout.json
|
[
"183020484",
"PRODUCED",
"FROM",
"B&W",
"WEB",
"SITE",
"During",
"cross-examination,",
"Ogden",
"also",
"took",
"the",
"industry’s",
"standard",
"position",
"that",
"even",
"for",
"active",
"smoking,",
"scientific",
"proof",
"of",
"causation",
"of",
"disease",
"has",
"not",
"been",
"~°",
"adequately",
"established.”’",
"Christopher",
"Coggins,",
"senior",
"vice",
"president",
"for",
"science",
"and",
"technology",
"at",
"cigarette",
"maker",
"Lorillard",
"Inc.,",
"also",
"testified",
"about",
"his",
"failed",
"efforts",
"to",
"induce",
"lung",
"cancer",
"in",
"rats",
"he",
"had",
"exposed",
"to",
"secondhand",
"smoke",
"while",
"at",
"a",
"prior",
"scientific",
"post",
"with",
"R.J.",
"Reynolds.",
"Despite",
"the",
"animals’",
"exposure",
"to",
"*",
"tvery,",
"very",
"high",
"concentrations",
"of",
"smoke''",
"over",
"long",
"periods",
"of",
"time,",
"*",
"\"",
"we",
"did",
"not",
"sée",
"any",
"response",
"in",
"the",
"lungs",
"whatsoever,\"’",
"Coggins",
"said.",
"Based",
"on",
"animal",
"studies",
"and",
"other",
"research,",
"€oggins",
"said",
"there",
"is",
"no",
"scientific",
"basis",
"10",
"conclude",
"that",
"secondhand",
"smoke",
"-~",
"at",
"home",
"or",
"at",
"work",
"is",
"even",
"a",
"risk",
"factor",
"for",
"disease.\"’",
"Lawyers",
"for",
"the",
"flight",
"attendants",
"have",
"relied",
"heavily",
"on",
"three",
"reports",
"by",
"the",
"National",
"Academy",
"of",
"Sciences,",
"the",
"U.S.",
"surgeon",
"general",
"and",
"the",
"Environmental",
"Protection",
"Agency,",
"concluding",
"that",
"secondhand",
"smoke",
"is",
"a",
"significant",
"cause",
"of",
"lung",
"cancer",
"in",
"nonsmokers.",
"Those",
"reports,",
"in",
"turn,",
"were",
"pased",
"largely",
"on",
"studies",
"showing",
"elevated",
"rates",
"of",
"lung",
"cancer",
"among",
"spouses",
"of",
"smokers",
"who",
"that",
"the",
"opposite",
"is",
"true.",
"The",
"industry's",
"lead-off",
"witness,",
"aviation",
"expert",
"Martin",
"Godley,",
"testified",
"that",
"the",
"ventilation",
"systems",
"of",
"jetliners",
"turn",
"over",
"the",
"air",
"every",
"few",
"minutes,",
"flushing",
"out",
"smoke",
"and",
"other",
"contaminants,",
"whereas",
"a",
"full",
"exchange",
"of",
"air",
"in",
"a",
"home",
"can",
"take",
"hours.",
"But",
"plaintiffs",
"lawyer",
"Stanley",
"Rosenblatt",
"hopes",
"that",
"what",
"sticks",
"in",
"jurors'",
"minds",
"are",
"the",
"large",
"sums",
"the",
"industry",
"paid",
"for",
"its",
"witnesses’",
"expertise,",
"which",
"he",
"brought",
"out",
"in",
"cross-examination.",
"Godley",
"acknowledged",
"that",
"tobacco",
"companies",
"have",
"paid",
"his",
"consulting",
"business",
"more",
"than",
"$300,000",
"for",
"work",
"on",
"this",
"case",
"and",
"other",
"projects.",
"And",
"Jolanda",
"Janczewski,",
"@",
"ventilation",
"expert",
"who",
"also",
"testified",
"|ast",
"week,",
"said",
"she",
"and",
"her",
"company,",
"Consolidated",
"Safety",
"Services,",
"had",
"received",
"preathed",
"secondhand",
"smoke",
"at",
"home.",
"Reflecting",
"the",
"crucial",
"role",
"of",
"these",
"spousal",
"studies,",
"plaintiffs",
"have",
"peen",
"trying",
"to",
"show",
"that",
"airline",
"cabins",
"weré",
"smokier",
"than",
"the",
"homes",
"of",
"cigarette",
"smokers,",
"while",
"the",
"industry",
"has",
"maintained",
"more",
"than",
"$800,000",
"from",
"tobacco",
"companies",
"in",
"recent",
"years.",
"Tobacco",
"lawyers,",
"however,",
"are",
"not",
"only",
"concerned",
"with",
"jurors’",
"reactions",
"to",
"testimony",
"in",
"court.",
"They",
"also",
"fear",
"the",
"jurors",
"might",
"see",
"the",
"highly",
"publicized",
"developments",
"in",
"the",
"smoking",
"wars",
"as",
"evidence",
"of",
"industry",
"wrongdoing.",
"A",
"victory",
"for",
"the",
"flight",
"attendants",
"could",
"mean",
"collective",
"damages",
"in",
"the",
"tens",
"of",
"millions",
"of",
"even",
"billions",
"of",
"dollars,",
"and",
"could",
"make",
"the",
"industry",
"vulnerable",
"to",
"more",
"passive—smoking",
"claims.",
"Conversely,",
"an",
"industry",
"victory",
"would",
"eliminate",
"for",
"all",
"time",
"the",
"threat",
"of",
"mass",
"claims",
"by",
"the",
"one",
"group,",
"flight",
"attendants,",
"who",
"may",
"have",
"the",
"best",
"chance",
"of",
"winning",
"a",
"passive—smoking",
"case.",
"Equally",
"important,",
"the",
"case",
"is",
"one",
"of",
"several",
"legal",
"pattles",
"that",
"will",
"influence",
"the",
"tone",
"and",
"substance",
"of",
"congressional",
"debate",
"this",
"winter",
"on",
"legislation",
"10",
"implement",
"the",
"tobacco",
"peace",
"accord.",
"Others",
"include",
"Texas'",
"Medicaid",
"suit",
"against",
"the",
"industry,",
"set",
"for",
"trial",
"next",
"month,",
"and",
"an",
"upcoming",
"ruling",
"by",
"a",
"federal",
"appeals",
"court",
"on",
"the",
"Food",
"and",
"Drug",
"Administration’s",
"authority",
"to",
"regulate",
"tobacco",
"products.",
"Victories",
"by",
"the",
"industry",
"would",
"strengthen",
"its",
"hand",
"in",
"congressional",
"negotiations,",
"while",
"defeats",
"would",
"embolden",
"anti-smoking",
"groups",
"and",
"tobacco",
"foes",
"in",
"Congress",
"to",
"raise",
"the",
"price",
"of",
"peace.",
"Defense",
"testimony",
"in",
"the",
"Broin",
"case",
"is",
"expected",
"to",
"continue",
"well",
"into",
"next",
"month,",
"after",
"which",
"jurors",
"will",
"decide",
"two",
"limited",
"questions:",
"Does",
"secondhand",
"smoke",
"cause",
"lung",
"cancer",
"and",
"other",
"diseases?",
"And",
"did",
"the",
"industry",
"commit",
"fraud",
"by",
"concealing",
"or",
"misrepresenting",
"the",
"dangers?",
"1f",
"the",
"answer",
"is",
"no,",
"the",
"companies",
"win.",
"If",
"it's",
"yes,",
"@",
"second",
"phase",
"will",
"follow",
"in",
"which",
"plaintiffs",
"will",
"try",
"to",
"prové",
"that",
"the",
"specific",
"ailments",
"of",
"flight",
"attendants",
"designated",
"as",
"representatives",
"of",
"the",
"class",
"action",
"were",
"caused",
"by",
"secondhand",
"smoke.",
"Copyright",
"(C)",
"The",
"Los",
"Angeles",
"Times",
"Washington",
"Post",
"News",
"Service",
"Received",
"by",
"NewsEDGE/LAN:",
"09/29/27",
"02:27:14",
"3",
"—",
"NewsEDGE",
"News"
] |
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531376115+-6129-2.layout.json
|
[
"RIRI",
"News",
"Report",
"May",
"6,",
"1997",
"“People",
"were",
"stopping",
"each",
"other",
"in",
"the",
"hall",
"and",
"asking,",
"‘How",
"long",
"did",
"you",
"last?’",
"*",
"said",
"opposition",
"councilor",
"Pierre",
"Goyer,",
"an",
"incorrigible",
"Gitanes",
"smoker.",
"“Everyone's",
"laughing",
"about",
"it,",
"but",
"whether",
"they’ll",
"laugh",
"in",
"a",
"month",
"is",
"another",
"question.”",
"Last",
"July,",
"Mayor",
"Pierre",
"Bourque",
"announced",
"the",
"city",
"would",
"join",
"the",
"rest",
"of",
"the",
"country’s",
"big",
"cities",
"in",
"going",
"smokefree.",
"Employees",
"were",
"told",
"they",
"would",
"have",
"to",
"take",
"their",
"cigarettes",
"outside",
"beginning",
"May",
"1.",
"Montreal",
"was",
"a",
"definite",
"late-comer",
"to",
"the",
"issue:",
"Ottawa",
"cleared",
"the",
"air",
"in",
"its",
"municipal",
"buildings",
"in",
"1976",
"and",
"Toronto",
"followed",
"in",
"1977,",
"Some",
"wags",
"at",
"city",
"hall",
"have",
"suggested",
"the",
"new",
"rules",
"will",
"never",
"apply",
"to",
"members",
"of",
"the",
"executive",
"committee.",
"A",
"few",
"catty",
"secretaries",
"have",
"suggested",
"that",
"with",
"those",
"big",
"private",
"offices",
"and",
"no",
"one",
"around",
"to",
"witness",
"the",
"offense,",
"it",
"will",
"be",
"easy",
"for",
"certain",
"politicians",
"to",
"sneak",
"a",
"smoke.",
"But",
"Goyer",
"said",
"he",
"would",
"never",
"flout",
"the",
"law",
"in",
"such",
"a",
"way.",
"Of",
"course,",
"however,",
"a",
"few",
"allowances",
"might",
"be",
"made",
"for",
"Day",
"One.",
"“1",
"was",
"out",
"of",
"the",
"office",
"for",
"three",
"hours",
"today",
"and",
"I",
"still",
"ended",
"up",
"breaking",
"down",
"once,”",
"he",
"said,",
"laughing.",
"“At",
"10:30,",
"there",
"were",
"three",
"councilors",
"and",
"a",
"secretary",
"out",
"on",
"the",
"balcony,",
"puffing",
"away.",
"Another",
"fellow",
"Gitanes",
"smoker",
"was",
"smart",
"enough",
"to",
"take",
"a",
"vacation.”",
"Littered",
"With",
"Butts",
"At",
"the",
"end",
"of",
"a",
"long,",
"smokefree",
"day,",
"the",
"city’s",
"buildings",
"were",
"a",
"sight.",
"Every",
"doorstep",
"was",
"littered",
"in",
"fresh",
"cigarette",
"butts.",
"At",
"the",
"Chaussegros",
"de",
"Lery",
"building",
"beside",
"city",
"hall,",
"a",
"cloud",
"of",
"noxious",
"smoke",
"hung",
"in",
"a",
"covered",
"entryway.",
"But",
"inside",
"the",
"clean",
"air",
"was",
"almost",
"perfumed.",
"At",
"the",
"municipal",
"courthouse,",
"a",
"security",
"guard",
"said",
"he’d",
"had",
"to",
"ask",
"only",
"two",
"people",
"to",
"stop",
"smoking",
"in",
"the",
"hallways.",
"“When",
"you",
"take",
"away",
"ashtrays,",
"it’s",
"too",
"inconvenient",
"to",
"smoke,”",
"he",
"said,",
"puffing",
"away",
"on",
"the",
"courthouse",
"steps.",
"But",
"two",
"employees",
"smoking",
"at",
"the",
"fountain",
"beside",
"city",
"hall",
"said",
"it’s",
"hypocritical",
"for",
"the",
"Bourque",
"administration",
"to",
"condemn",
"smoking",
"at",
"city",
"hall",
"but",
"condone",
"cigarette",
"sponsorship",
"for",
"the",
"city’s",
"festivals.",
"“That’s",
"about",
"money,",
"so",
"it’s",
"different,”",
"said",
"one",
"woman.",
"That,",
"and",
"more,",
"bothers",
"opposition",
"councilor",
"Marvin",
"Rotrand.",
"He",
"said",
"that",
"if",
"the",
"city",
"really",
"wanted",
"to",
"do",
"something",
"about",
"the",
"health",
"risks",
"of",
"smoking,",
"it",
"would",
"beef",
"up",
"its",
"antismoking",
"bylaw,",
"which",
"calls",
"for",
"restaurants",
"with",
"more",
"than",
"25",
"seats",
"to",
"establish",
"nosmoking",
"areas.",
"But",
"the",
"bylaw",
"is",
"seldom",
"enforced",
"and",
"doesn’t",
"call",
"for",
"partitions",
"between",
"smokers",
"and",
"nonsmokers.",
"Waorse,",
"he",
"said,",
"smoking",
"in",
"public",
"buildings",
"including",
"municipal",
"buildings",
"has",
"been",
"banned",
"by",
"a",
"provincial",
"law",
"since",
"1987.",
"Montreal",
"just",
"never",
"got",
"around",
"to",
"enforcing",
"it.",
"“The",
"city",
"could",
"have",
"done",
"this",
"years",
"and",
"years",
"ago,”",
"Rotrand",
"fumed.",
"“But",
"we",
"are",
"generally",
"the",
"last",
"at",
"many",
"things,",
"and",
"any",
"public-health",
"law",
"here",
"is",
"put",
"off",
"for",
"years.”",
"Source:",
"The",
"Gazette",
"(Montreal);",
"2-May-97",
"Author:",
"Carolyn",
"Adolph",
"Z119",
"/gles",
"RJR0000000026006822",
"70052",
"1972"
] |
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"(1964)",
"B7.",
"Aschkenssy-Lels,",
"P",
"dreh,",
"Sci.",
"Physiol,",
"16,",
"203-11",
"(1962)",
"8.",
"Rodgers,",
"1.",
"A,",
"Psychosomat.",
"Med,",
"vol.",
"XXVIIL,",
"498-813",
"(1965",
"89,",
"Wallgrea,",
"H,",
"Forsander,",
"0,",
"1.",
"Natr,",
"17,",
"45357",
"(1963)",
"90,",
"Nickols,",
"J.",
"R.,",
"Sei.",
"dw,",
"212,",
"§0-83",
"(1965)",
"91,",
"Schuster,",
"C.",
"R,",
"Villarreal,",
"J.",
"The",
"'",
"experimental",
"onalyels",
"of",
"opioid",
"dependence",
"(Am.",
"Col",
"Neurapsychopharmacal..",
"San",
"Jua,",
"967",
"=",
"[",
"1967)",
"92,",
"Davis,",
"M.,",
"Nichols,",
"J.",
"R.",
"Fiyeho-",
"Phtarimacalogia,",
"B,",
"139-43",
"(1962)",
"PTS60P995",
"93.",
"Clark,",
"R,",
"Palish,",
"E,",
"Seience,",
"132,",
"94.",
"Mello.",
"N.",
"K..",
"Mendelson,",
"1.,",
"Py",
"223-24",
"(1960)",
"somat,",
"Med.,",
"vol.",
"XXV,",
"535-50",
"(1966)",
"95.",
"‘Thompsom,",
"T.,",
"Ostlund,",
"W..",
"/.",
"Conf.",
"Physiol.",
"Prychal,’",
"60,",
"188-32",
"(1968",
"9,",
"Vaillant,",
"G.,",
"Scieutifc",
"Basis",
"of",
"Drug",
"Depandence,",
"(H.",
"Steinbera,",
"Ed..",
"J.",
"1.",
"Churchifl,",
"Landon,",
"Eugland.",
"1968)",
"97.",
"Skinner,",
"B.",
"F,",
"The",
"Brhavior",
"98",
"Ferster,",
"C.",
"B,",
"of",
"Organisms,",
"(Appleton-Century-",
"Crofts,",
"New",
"York,",
"1934)",
">",
"Skinner,",
"B.",
".",
"Scheduies",
"of",
"Reinforcement.",
"(Au-",
"pleton-Century-Crafts,",
"New",
"Yark.",
"105",
"99.",
"Morse,",
"W.",
"H..",
"Intermitient",
"e",
"100",
"Wesks,",
"J.",
"R.,",
"Calling,",
"R,",
".",
"forcenent.",
"Ta",
"Operant",
"Behovior",
"Aveas",
"of",
"Research",
"aud",
"Applicn.",
"fior,",
"32-108",
"(Honlg,",
"W.",
"K.",
"Ed.,",
"Anpleton-Centary-Crofts,",
"New",
"York,",
"1965)",
".",
"Pateerne",
"of",
"intravenous",
"sell-injection",
"by",
"morphine-addicted_rats.",
"In",
"The",
"Addictive",
"States,",
"288-98",
"(Witder,",
"Ed,",
"The",
"Willisn",
"Wilking",
"Co.",
"1968)",
"Collins,",
"R.",
"J.,",
"Wecks,",
"J.",
"R,",
"drch",
"Expti.",
"Pathol.",
"Pharmakol,",
"249,",
"$09-14",
"(1965)",
"Kelicher,",
"R.",
"T,",
"Gollub,",
"L.",
"R,",
"/.",
"Expil.",
"Anal",
"Behav,",
"5,",
"543.97",
"(1962)",
"Kellcher,",
"R.",
"T.,",
"Chaining",
"and",
"Coue",
"ditioned",
"Reinforcement,",
"In",
"Qper.",
"ant",
"Bebavior;",
"Aveas",
"of",
"Researrh",
"and",
"Applicaiion",
"160212",
"(Fanig,",
"W.",
"K.",
"Ed,",
"Appleton-Ceutury",
"Crafts,",
"New",
"York,",
":956)",
"Seuster,",
"C.",
"R,",
"Weods,",
"J.",
"H,",
"Intern.",
"]",
"Addict,",
"8,",
"223-30",
"(1968)",
"101",
"102,",
"103",
".",
"Goldberg,",
"S.",
"1561y",
"Wikler,",
"‘A.,",
"FPescor,",
"F.",
"T..",
"Psycho-",
"pharmacologia,",
"10,",
"255-84",
"sen",
"Schuster,",
"C.",
"R,",
"Tepil,",
"Ao’",
"Bensns",
"0,",
"236-43",
"(1967",
"Djahauguiri,",
"B.,",
"Richelle,",
"M.,",
"Fan-",
"taine,",
"O,",
"Psychopharmacalogia,",
"36372",
"(1966)",
"Schuster,",
"C.",
"R,",
"Dockens,",
"W.",
".,",
"Woods,",
"J.",
"H,",
"Paychosharmaco.",
"logia,",
"8,",
"170-87",
"(1986)",
"Walles,",
"M.",
"B..",
"J.",
"Bxptl.",
"Anal",
"Behav.,",
"4,",
"351-59",
"(1961)",
".",
"Wikler,",
"A,",
"Brit.",
"J.",
"Addict,",
"57,",
"73",
"DURATION",
"OF",
"LOCA].",
"ANESTHESIA*",
"By",
"F.",
"P.",
"LupusNa",
"Steriing-Winthrop",
"Research",
"Institute,",
"Remsseloer,",
"New",
"Vork",
"In",
"regard",
"to",
"duration",
"of",
"action",
"local",
"anesthetics",
"have",
"been",
"classified",
"into",
"three",
"groups—short-acting",
":",
"procaine,",
"parethoxycaine",
"(Intracaine),",
"pipera-",
"caine",
"(Metycaine),",
"and",
"butethamine",
"(Monocaine);",
"intermediate:",
"lidocaine",
"(Xylocaine)",
"and",
"hexylcaine",
"(Cyclaine);",
"long-acting?",
"tetracaine",
"(Ponto-",
"caine)",
"and",
"dibucaine",
"(Nupercaine)",
"[Pitkin",
"(1)).",
"Newer",
"local",
"anesthetics",
"could",
"be",
"added",
"to",
"one",
"or",
"another",
"of",
"these",
"groups",
"with",
"borderline",
"cases",
"more",
"difficult",
"to",
"classify.",
"This",
"is",
"an",
"empirical",
"classification",
"based",
"on",
"a",
"con-",
"cept",
"of",
"duration",
"of",
"action",
"which",
"is",
"deceptively",
"simple—at",
"effective",
"clinical",
"doses",
"the",
"duration",
"of",
"anesthesia",
"produced",
"by",
"members",
"of",
"the",
"first",
"group",
"(procaine,",
"intracaine,",
"etc.)",
"is",
"considerably",
"shorter",
"than",
"that",
"following",
"the",
"injection",
"of",
"tetracaine",
"and",
"dibucaine",
"(third",
"group).",
"However,",
"for",
"each",
"Tocat",
"anesthetic",
"the",
"doses",
"used",
"cliuically",
"have",
"been",
"arrived",
"at",
"by",
"an",
"empiri-",
"cal",
"process",
"of",
"selection",
"in",
"which",
"potency,",
"systemic",
"toxicity,",
"irritancy,",
"time",
"of",
"onsct,",
"and",
"even",
"duration",
"of",
"action",
"have",
"been",
"considered.",
"The",
"separation",
"between",
"short-",
"and",
"long-acting",
"compounds",
"is",
"somewhat",
"more",
"difficult",
"in",
"Jocal",
"anesthetic",
"studies",
"and",
"requires",
"the",
"determination",
"of",
"other",
"The",
"duration",
"of",
"experimental",
"anesthesia",
"increases",
"with",
"the",
"dose,",
"and",
"there",
"are",
"several",
"publications",
"showing",
"a",
"linear",
"relationship",
"duration",
"in",
"minutes",
"and",
"the",
"logarithm",
"of",
"the",
"concentration",
"(ot",
"dose).",
"Since",
"in",
"experimental",
"anesthesia",
"the",
"effective",
"range",
"covers",
"a",
"few",
"to",
"100",
"or",
"more",
"minutes,",
"it",
"is",
"possible",
"to",
"find",
"doses",
"of",
"short-acting",
"compounds",
"(procaine,",
"for",
"example)",
"which",
"produce",
"ancsthesia",
"of",
"longer",
"duration",
"than",
"that",
"follawing",
"the",
"injection",
"of",
"a",
"small",
"dose",
"of",
"a",
"long-acting",
"compound",
"like",
"dibucaine,",
"Even",
"if",
"solutions",
"of",
"the",
"same",
"concentration",
"are",
"compared,",
"the",
"resulls",
"may",
"be",
"misteading",
"if",
"the",
"shorter-acting",
"compound",
"is",
"considerably",
"more",
"potent",
"than",
"the",
"other.",
"It",
"is",
"obvious",
"that",
"comparative",
"duration",
"tests",
"should",
"be",
"carried",
"out",
"with",
"equiactive",
"solutions",
"or",
"doses.",
"The",
"local",
"anesthetic",
"activity",
"or",
"potency",
"of",
"a",
"compound",
"could",
"be",
"ex-",
"pressed",
"by",
"the",
"reciprocal",
"of",
"its",
"thresheld",
"or",
"minimal",
"anesthetic",
"concentra-",
"Hon",
"(TAC).",
"The",
"TAC",
"would",
"vary",
"for",
"each",
"type",
"of",
"nerve",
"fiber;",
"in",
"general",
"the",
"TAC",
"would",
"be",
"positively",
"correlated",
"with",
"fiber",
"diameter",
"(2-5),",
"The",
"TAC",
"can",
"be",
"determined",
"on",
"isolated",
"merve",
"fibers,",
"with",
"an",
"approximation",
"which",
"depends",
"mainly",
"on",
"the",
"concentration",
"intervals",
"of",
"the",
"solutions",
"tested.",
"When",
"a",
"frog's",
"isolated",
"sciatic",
"nerve",
"fiber",
"was",
"blocked",
"by",
"a",
"threshold",
"or",
"slightly",
"higher",
"concentration",
"of",
"cocaine,",
"onset",
"(after",
"drug",
"addition)",
"and",
"*The",
"survey",
"of",
"literature",
"pertaining",
"to",
"this",
"review",
"was",
"concluded",
"in",
"July",
"1968",
"503"
] |
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356,
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415,
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530
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214,
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547,
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558
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288,
558
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304,
548,
318,
558
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331,
548,
365,
558
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378,
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390,
559
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402,
548,
446,
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244,
561,
265,
572
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275,
562,
313,
571
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324,
562,
360,
573
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202,
575,
217,
584
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227,
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271,
586
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282,
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286,
586
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300,
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311,
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366,
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377,
580,
387,
585
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397,
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446,
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243,
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260,
604
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269,
591,
309,
600
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318,
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348,
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356,
590,
406,
600
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414,
591,
445,
600
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[
243,
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292,
614
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604,
326,
615
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335,
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376,
616
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[
385,
609,
394,
614
],
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404,
605,
445,
614
],
[
243,
617,
307,
628
],
[
315,
619,
366,
629
],
[
374,
621,
383,
628
],
[
391,
619,
409,
628
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[
422,
620,
445,
630
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[
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"by",
"\"The",
"CPSC",
"must",
"consider",
"a",
"wide",
"wvariety",
"of",
"information",
"and",
"factors",
"in",
"promuigating",
"a",
"rule:",
"(1)",
"*‘relovant",
"available",
"product",
"data",
"including",
"the",
"tesults",
"of",
"research,",
"development,",
"testing,",
"and",
"investigation",
"activities",
"comducted",
"generally",
"and",
"pursuant",
"fo",
"this",
"chapter,”",
"(2)",
"the",
"needs",
"of",
"the",
"elderly",
"and",
"handicapped.",
"15",
"US.C.",
"§",
"2058(e).",
"Difference",
"between",
"H.R.",
"1130",
"and",
"customary",
"CPSC",
"rule",
"making",
"procedures",
"4.",
"With",
"whom",
"must",
"the",
"CPSC",
"consult",
"and",
"what",
"information",
"must",
"it",
"take",
"into",
"account",
"when",
"developing",
"and",
"promulgating",
"a",
"‘The",
"CPSC",
"must",
"consult",
"with",
"the",
"National",
"Institute",
"of",
"Standacds",
"and",
"‘Technology",
"and",
"“other",
"federal",
"and",
"state",
"agencies",
"engaged",
"in",
"fire",
"safety.”",
"§",
"2¢a)(1).",
"The",
"CPSC",
"musl",
"also",
"take",
"account",
"the",
"final",
"report",
"to",
"Congress",
"of",
"the",
"CPSC",
"and",
"the",
"Technical",
"Advisory",
"Group",
"concluding",
"that",
"cigarettes",
"with",
"a",
"fow",
"propensity",
"are",
"already",
"available.",
"§",
"2a)(2).",
"H.R.",
"1130",
"requires",
"the",
"CPSC",
"to",
"take",
"into",
"account",
"considerably",
"less",
"information",
"and",
"engage",
"in",
"considerably",
"less",
"fact",
"finding",
"and",
"research",
"before",
"promulgating",
"2",
"standard.",
"5.",
"Is",
"the",
"public",
"entitled",
"1o",
"participate",
"in",
"the",
"rule",
"making",
"process?",
"Yes.",
"The",
"CPSC",
"must",
"provide",
"inierested",
"pariies",
"with",
"an",
"opportunity",
"{o",
"participate",
"in",
"the",
"mile",
"making",
"process,",
"However,",
"the",
"CPSC",
"may",
"1imit",
"this",
"panticipation",
"to",
"the",
"submission",
"of",
"written",
"statements.",
"§",
"U.8.C.",
"§",
"553(c).",
"Yes.",
"The",
"agency",
"must",
"provide",
"interested",
"patties",
"with",
"an",
"opporiunity",
"to",
"participate",
"and,",
"in",
"addition",
"to",
"allowing",
"writien",
"submissions,",
"must",
"provide",
"interested",
"persons",
"with",
"the",
"opportunity",
"to",
"make",
"an",
"oral",
"presenfation.",
"15",
"U.S.C.",
"§",
"2058(d)}2).",
"H.K.",
"1130",
"does",
"not",
"enitiie",
"inicresied",
"paities",
"to",
"make",
"oral",
"prescatations",
"before",
"the",
"CPSC",
"and",
"thus",
"limits",
"public",
"input",
"into",
"the",
"CPSC’s",
"rule",
"making",
"process.",
"B.",
"What",
"musi",
"the",
"final",
"rule",
"inciude?",
"The",
"provisions",
"of",
"tie",
"rute.",
"(1)",
"The",
"provisions",
"of",
"the",
"ik,",
"(2)",
"the",
"CPSC’s",
"findings",
"as",
"mandated",
"by",
"statute",
"(se¢",
"B-1",
"and",
"B-6,",
"infra),",
"and",
"(3)",
"the",
"CPSC's",
"regulatory",
"analysis",
"as",
"mandated",
"by",
"statute",
"(so¢",
"B-5,",
"infra).",
"15",
"U,S.C.",
"§",
"2058(0).",
"The",
"final",
"rule",
"must",
"be",
"issued",
"(or",
"withdraws1)",
"within",
"60",
"days",
"of",
"publication",
"of",
"the",
"proposed",
"standard",
"(i.g.,",
"not",
"more",
"than",
"14",
"months",
"after",
"publication",
"of",
"the",
"advance",
"notice",
"of",
"proposed",
"rule",
"making),",
"although",
"this",
"time",
"period",
"may",
"be",
"extended",
"by",
"the",
"CPSC",
"for",
"good",
"cause.",
"15",
"U.S.C.",
"§",
"2058(d)(1).",
"HLR.",
"1130",
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"o",
"disclose",
"considerably",
"less",
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"how",
"it",
"arrived",
"at",
"a",
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"7.",
"What",
"period",
"of",
"tim¢",
"does",
"the",
"CPSC",
"have",
"in",
"which",
"to",
"promulgate",
"a",
"final",
"rule?",
"The",
"final",
"rule",
"must",
"be",
"issued",
"within",
"eighteen",
"months",
"of",
"the",
"Act’s",
"chactment.",
"§",
"2(a).",
"Because",
"H.K,",
"1130",
"docs",
"not",
"allow",
"the",
"CPSC",
"10",
"extend",
"the",
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"allotted",
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"promulgate",
"a",
"final",
"sule,",
"it",
"could",
"result",
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"the",
"adoptioa",
"of",
"a",
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"sooner",
"than",
"under",
"the",
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2046807567_7643-37.layout.json
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0001039501-85.layout.json
|
[
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518415175+-5177-0.layout.json
|
[
"11:22",
"R.J.",
"REYNOLDS",
"TOB.",
"S16",
"499",
"@572",
"o",
"D70,",
"_",
"\"",
"Tobacco",
"Company",
"G.",
"H.",
"MOULTON",
"February",
"26,",
"1998",
"Key",
"Account",
"Manager",
"6500",
"Jericho",
"Turnpike,",
"Suite",
"207",
"Commack.",
"NY",
"11725",
"516-499-0254",
"Fax",
"516-499-0572",
"To:",
"M.",
"A.",
"Young",
"Voice",
"Mail",
"22?-:335%255",
"MERCHANDISING",
"]",
"Subject:",
"Status",
"Report",
"February",
"Duane",
"Reade",
"(ID¥",
"1417",
"00",
"00)",
"(75",
"stores)",
"New",
"World",
"Concepts",
"negotiations",
"continue",
"to",
"proceed",
"with",
"this",
"chain.",
"It",
"has",
"been",
"decided",
"that",
"RJR",
"fixtures",
"will",
"not",
"be",
"utilized,",
"There",
"are",
"several",
"scenarios",
"that",
"are",
"being",
"evaluated,",
"and",
"we",
"anticipate",
"the",
"decision",
"by",
"the",
"first",
"week",
"in",
"March,",
"Dairy",
"Barn",
"(ID¥",
"1011",
"00",
"00)",
"(54",
"stores)",
"Mr.",
"Bill",
"Gilman,",
"Buyer",
"has",
"approved",
"a",
"promotion",
"schedule",
"that",
"will",
"allow",
"buydowns",
"for",
"all",
"stores,",
"as",
"a",
"test;",
"however,",
"1",
"will",
"not",
"implement",
"this",
"until",
"&",
"pricing",
"sign",
"is",
"developed",
"that",
"can",
"cffectively",
"communicate",
"the",
"program.",
"Anticipate",
"implementation",
"in",
"March.",
"Amaco",
"(ID¥",
"0003",
"07",
"06)",
"(30",
"stations)",
"Met",
"with",
"Mr.Clco",
"Papadatos,",
"Field",
"Manager",
"to",
"discuss",
"the",
"implementation",
"of",
"merchandising",
"program",
"and",
"advertising,",
"He",
"has",
"requested",
"our",
"sales",
"people",
"place",
"banners",
"in",
"all",
"stores",
"to",
"communicate",
"price",
"reductions.",
"Hess",
"(0353",
"02",
"00)",
"(45",
"locations)",
"Attended",
"a",
"meeting",
"with",
"the",
"Hess",
"Mart",
"Managers.",
"Reviewed",
"RJR",
"programs",
"and",
"contract",
"requirements.",
"A",
"very",
"positive",
"response",
"was",
"communicated",
"and",
"it",
"appears",
"that",
"RJR",
"reps",
"are",
"contacting",
"their",
"accounts",
"on",
"a",
"regular",
"basis.",
"Wallace",
"Oil",
"(ID¥",
"2358",
"00",
"00)",
"(11",
"locations)",
"AM",
"Mallardi",
"presented",
"RIR",
"New",
"World",
"merchandisers/dimensions",
"to",
"Mr.",
"Bob",
"Decker,",
"Buyer,",
"who",
"is",
"int",
"in",
"testing",
"NSS",
"in",
"the",
"new",
"corporate",
"location",
"that",
"is",
"being",
"built.",
"He",
"also",
"implemented",
"Partners",
"contracts",
"in",
"one",
"new",
"corporate",
"location",
"during",
"February.",
"SLIS",
"Tpgrg",
"*We",
"work",
"for",
"smokers.'"
] |
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2022161585_2022161648-36.layout.json
|
[
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516059752+-9756-4.layout.json
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2063678202_8204-1.layout.json
|
[
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] |
0001039501-42.layout.json
|
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2046807567_7643-31.layout.json
|
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"DRAFT",
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95681072_1074-0.layout.json
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531376115+-6129-9.layout.json
|
[
"RIRI",
"News",
"Report",
"May",
"6,",
"1997",
"WHO",
"scientists",
"called",
"on",
"the",
"United",
"States",
"to",
"become",
"a",
"role",
"model",
"for",
"a",
"healthy",
"lifestyle.",
"*Just",
"as",
"North",
"America",
"has",
"exported",
"negative",
"aspects",
"of",
"its",
"culture,",
"we",
"hope",
"it",
"will",
"export",
"positive",
"aspects",
"of",
"its",
"culture",
"as",
"well,”’",
"Brandling-Bennett",
"said.",
"Of",
"the",
"52",
"million",
"deaths",
"worldwide",
"last",
"year,",
"the",
"report",
"said,",
"over",
"17",
"million",
"were",
"caused",
"by",
"infectious",
"diseases,",
"over",
"15",
"million",
"by",
"heart",
"disease,",
"over",
"six",
"million",
"by",
"cancer",
"and",
"about",
"three",
"million",
"by",
"respiratory",
"diseases.",
"Smoking-related",
"deaths",
"Smoking-related",
"disease",
"alone",
"accounted",
"for",
"about",
"three",
"million",
"deaths,",
"the",
"report",
"said.",
"In",
"many",
"countries,",
"said",
"Paul",
"Kieihues,",
"the",
"WHO’s",
"chief",
"cancer",
"researcher,",
"smoking",
"is",
"seen",
"as",
"part",
"of",
"the",
"acquisition",
"of",
"a",
"Western",
"lifestyle.",
"Jan",
"Smith,",
"a",
"spokeswoman",
"for",
"R.J.",
"Reynolds",
"Tobacco,",
"which",
"makes",
"Camel",
"cigarettes,",
"disputed",
"the",
"idea",
"that",
"the",
"United",
"States",
"was",
"at",
"fault",
"for",
"spreading",
"smoking.",
"It",
"is",
"somewhat",
"naive",
"to",
"leap",
"to",
"the",
"conclusion",
"that",
"people",
"in",
"countries",
"outside",
"the",
"U.S.",
"did",
"not",
"smoke",
"before",
"U.S.",
"tobacco",
"companies",
"entered",
"those",
"markets,’””",
"Smith",
"said.",
"“*What",
"international",
"competition",
"affects",
"is",
"the",
"brand",
"choice",
"of",
"smokers,”",
"she",
"said.",
"““Itis",
"not",
"whether",
"they",
"will",
"smoke,",
"but",
"what",
"brands",
"they",
"will",
"smoke.\"’",
"R.J.",
"Reynolds’",
"domestic",
"sales",
"last",
"year",
"were",
"$4.5",
"billion.",
"Its",
"international",
"sales",
"were",
"$3.6",
"billion.",
"Smith",
"said",
"the",
"world",
"cigarette",
"market",
"was",
"growing",
"at",
"the",
"rate",
"of",
"about",
"1",
"percent",
"a",
"year.",
"All",
"this",
"causes",
"worry",
"at",
"the",
"WHO,",
"a",
"Geneva-based",
"nonprofit",
"organization",
"that",
"works",
"to",
"improve",
"health",
"conditions",
"around",
"the",
"world.",
"Some",
"10",
"million",
"cases",
"of",
"cancer",
"were",
"diagnosed",
"last",
"year,",
"slightly",
"more",
"than",
"half",
"of",
"them",
"in",
"developing",
"countries.",
"In",
"2020,",
"the",
"report",
"estimates",
"at",
"least",
"15",
"million",
"people",
"will",
"develop",
"cancer,",
"with",
"a",
"doubling",
"of",
"cases",
"in",
"developing",
"countries.",
"Higher",
"rates",
"of",
"heart",
"disease",
"The",
"rates",
"of",
"heart",
"disease",
"will",
"also",
"spiral,",
"especially",
"in",
"the",
"developing",
"world,",
"but",
"the",
"WHO",
"researchers",
"said",
"it",
"was",
"harder",
"to",
"quantify.",
"Heart",
"disease",
"may",
"also",
"be",
"more",
"easily",
"headed",
"off",
"with",
"lifestyle",
"changes",
"than",
"cancer",
"is.",
"Diabetes—another",
"disease",
"largely",
"triggered",
"by",
"lifestyle",
"and",
"diet—will",
"likely",
"afflict",
"some",
"300",
"million",
"people",
"by",
"2025,",
"up",
"from",
"135",
"million",
"cases",
"now,",
"the",
"report",
"said.",
"Cases",
"will",
"triple",
"in",
"the",
"developing",
"world,",
"and",
"increase",
"by",
"45",
"percent",
"in",
"the",
"industrialized",
"world.",
"The",
"worldwide",
"trends",
"in",
"disease",
"mirrors",
"the",
"public",
"health",
"experience",
"within",
"the",
"United",
"States,",
"where",
"chronic",
"diseases",
"have",
"grown",
"along",
"with",
"a",
"rapidly",
"aging",
"population.",
"The",
"WHO",
"report",
"says",
"the",
"number",
"of",
"people",
"over",
"65",
"increased",
"to",
"380",
"million",
"between",
"1990",
"and",
"1995.",
"Life",
"expectancy",
"at",
"birth",
"worldwide",
"is",
"65",
"years,",
"up",
"by",
"almost",
"five",
"years",
"since",
"1980.",
"The",
"report’s",
"author,",
"Muthu",
"Subramanian,",
"said",
"life",
"expectancy",
"in",
"two",
"decades",
"will",
"be",
"around",
"75",
"years",
"worldwide.",
"tcL9",
"leles",
"10",
"RJR0000000026006822",
"70052",
"1978"
] |
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504221516_504221531-5.layout.json
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"at",
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"topographical",
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"fuactional",
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"sound",
"model",
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"remote,",
"the",
"reasonableness",
"of",
"the",
"hierachy.",
"of",
"cellular",
"element",
"con-",
"centrations:",
"as",
"these",
"relate",
"to",
"metabolic",
"function",
"suggests",
"that",
"a",
"threshold",
"for",
"biological",
"activity.",
"exists:",
"within:",
"a_",
"cell",
"at",
"104",
"atoms,",
"'",
"T",
"of:",
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"qualifiers.",
"appreciate",
"his",
"world,",
"but",
"at",
"the",
"cost",
"of",
"mortality.",
"Otherwise.",
"what.an",
"immortal-",
"ity,",
"what",
"2",
"life!'",
"Co",
"Summary",
"The",
"cellular",
"organism",
"operates",
"within",
"a'quantitative",
"rate",
"limit:",
"that",
"transcends",
"any'stalements'",
"Having",
"only:",
"qualitative",
"bases.",
"Thus:",
"concepts",
"concerning:",
"en-",
"croachments",
"on",
"response:",
"capabilities",
"over'a",
"lifespan",
"are",
"jnadequate",
"descrip-",
"tors",
"of",
"biological",
"activity.in",
"the",
"absence:",
"References",
"i.",
"“National",
"Primary",
"and",
"Secondary.",
"Air",
"Qual-",
"ity",
"Standards”’",
"Code",
"of",
"Federal",
"Regulations",
"42,",
"chap.",
"4,",
"part",
"410;",
"atso",
"'",
"Frderal",
"|",
"Register",
"36,",
"No.",
"84,",
"8185",
"(30",
"April",
"1971),",
"2..R.",
"R.",
"Beard",
"and",
"G,",
"A.",
"Werheim,",
"Amer.",
"J.",
"Public:Health",
"57,",
"2012",
"(1967).",
"et",
".",
"Webster's:",
"New",
"International",
"Dictionary.",
"of",
"the",
"English",
"Langucee",
"(Mérriam,",
"Springfield,",
"Mass:,",
"ed.",
"2,",
"unabridzed,",
"1958),",
".",
"G.",
"E:",
"Hutckinson,",
"Froe.",
"Net,",
"Acad.",
"Sd,",
"U,",
"S5,",
"930",
"(1984).",
"<",
"J.",
"L.",
"Webb.",
"Enzyme:",
"and'Metabolic.",
"Inkibitors",
"(Academic",
"Press,",
"New",
"York;",
".",
"1966),",
"vol,",
"3,",
"Hi",
"Gregarzik",
"and",
"H.",
"Passow,",
"PARusgers:",
"Arch.",
"Gesanite",
"Physiol.",
"Menschen",
"Tiere.",
"267,",
"13",
"(1958},",
".",
"A.",
"D.",
"Swanson",
"and",
"P,",
"D.",
"Boyer,",
"J.",
"Amer.",
"Chenr.",
"Spe.",
"79,",
"2178",
"195Mm.",
"8.",
"H.",
"M.",
"Segatiand",
"p.",
"D,",
".Boyer,",
"J.",
"Biol.",
"Chem,",
"208,",
"265:",
"(1953),",
"9.",
"V.",
"Massey,",
"Biochim,",
"Biophys.",
"Acia",
"39,",
"500",
"€1958).",
".",
"10.",
"1.",
"E:",
"Donne!lm.‘lr.,",
"and",
"R.",
"S.",
"Stafford,",
"in",
"Biockemical.",
"R,",
"st",
"to:",
"Envi",
"!",
"Stress;",
"1.",
"A,",
"Bemnstein,",
"E4.",
"(Plenum,",
"New",
"York;",
"1971),",
"p.",
"38.",
"M.",
"R.",
"P.",
"Monlock",
"and",
"W..",
"A,",
"Wood,",
"J.",
"Blol.",
"Chem.",
"204,",
"1\"",
"(1953),",
"S",
"w",
"e~",
"m",
"s",
"497",
"CL0SYI92001",
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1794,
2223
],
[
1801,
2199,
1856,
2218
],
[
1870,
2201,
1904,
2216
],
[
1917,
2202,
1933,
2217
],
[
1480,
2213,
1512,
2229
],
[
1528,
2209,
1619,
2238
],
[
1630,
2220,
1665,
2237
],
[
1679,
2220,
1701,
2236
],
[
1714,
2221,
1788,
2241
],
[
1801,
2224,
1889,
2244
],
[
1901,
2228,
1953,
2243
],
[
1488,
2235,
1570,
2252
],
[
1591,
2239,
1665,
2257
],
[
1686,
2243,
1781,
2261
],
[
1803,
2247,
1851,
2263
],
[
1873,
2249,
1912,
2268
],
[
1931,
2251,
1951,
2266
],
[
1490,
2259,
1555,
2277
],
[
1471,
2295,
1475,
2299
],
[
1487,
2284,
1509,
2299
],
[
1525,
2285,
1548,
2301
],
[
1564,
2286,
1644,
2304
],
[
1661,
2292,
1695,
2306
],
[
1711,
2292,
1729,
2308
],
[
1746,
2293,
1767,
2310
],
[
1783,
2295,
1845,
2314
],
[
1860,
2297,
1877,
2312
],
[
1891,
2298,
1951,
2314
],
[
1488,
2306,
1548,
2322
],
[
1562,
2308,
1601,
2324
],
[
1615,
2311,
1640,
2329
],
[
1654,
2313,
1697,
2328
],
[
1710,
2311,
1773,
2338
],
[
1460,
2332,
1475,
2347
],
[
1488,
2332,
1509,
2347
],
[
1522,
2333,
1548,
2348
],
[
1561,
2334,
1656,
2353
],
[
1667,
2339,
1688,
2354
],
[
1698,
2340,
1720,
2356
],
[
1728,
2341,
1794,
2361
],
[
1804,
2344,
1821,
2359
],
[
1833,
2344,
1880,
2360
],
[
1891,
2346,
1952,
2362
],
[
1487,
2354,
1524,
2373
],
[
1539,
2356,
1569,
2371
],
[
1585,
2359,
1648,
2377
],
[
1458,
2378,
1473,
2394
],
[
1486,
2379,
1507,
2395
],
[
1525,
2381,
1599,
2400
],
[
1615,
2380,
1700,
2408
],
[
1717,
2388,
1798,
2407
],
[
1815,
2392,
1861,
2407
],
[
1876,
2393,
1904,
2412
],
[
1920,
2394,
1952,
2409
],
[
1486,
2398,
1549,
2426
],
[
1837,
2426,
1839,
2427
],
[
1450,
2426,
1473,
2440
],
[
1486,
2427,
1500,
2441
],
[
1517,
2427,
1536,
2442
],
[
1553,
2428,
1701,
2452
],
[
1718,
2438,
1752,
2451
],
[
1767,
2438,
1786,
2453
],
[
1803,
2439,
1818,
2454
],
[
1835,
2440,
1917,
2458
],
[
1933,
2441,
1950,
2456
],
[
1485,
2447,
1602,
2466
],
[
1634,
2455,
1645,
2462
],
[
1723,
2465,
1736,
2473
],
[
1760,
2462,
1777,
2474
],
[
1809,
2460,
1852,
2472
],
[
1946,
2463,
1950,
2468
],
[
1484,
2470,
1552,
2490
],
[
1564,
2473,
1576,
2490
],
[
1596,
2476,
1616,
2492
],
[
1636,
2478,
1731,
2500
],
[
1750,
2482,
1781,
2499
],
[
1801,
2484,
1888,
2505
],
[
1906,
2486,
1949,
2502
],
[
1484,
2494,
1538,
2514
],
[
1554,
2498,
1608,
2517
],
[
1619,
2505,
1635,
2518
],
[
1648,
2503,
1674,
2518
],
[
1447,
2520,
1470,
2534
],
[
1483,
2520,
1504,
2535
],
[
1520,
2521,
1538,
2536
],
[
1556,
2523,
1643,
2541
],
[
1660,
2529,
1693,
2543
],
[
1711,
2530,
1737,
2545
],
[
1753,
2532,
1774,
2547
],
[
1791,
2532,
1856,
2551
],
[
1870,
2533,
1887,
2549
],
[
1902,
2533,
1947,
2549
],
[
1483,
2542,
1544,
2559
],
[
1559,
2545,
1595,
2565
],
[
1612,
2549,
1617,
2563
],
[
1634,
2550,
1704,
2569
],
[
1858,
2556,
1965,
2572
],
[
1464,
2046,
1473,
2061
],
[
1462,
2115,
1477,
2239
],
[
1449,
2158,
1486,
2183
],
[
1449,
2111,
1486,
2136
],
[
1847,
2632,
1879,
2647
],
[
2298,
2631,
2352,
3075
],
[
2388,
3040,
2502,
3063
]
] |
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