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0012212463-2.layout.json
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[
"ACTION",
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"Banding",
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"no",
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"realistic",
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"of",
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"a",
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"Williamson",
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"draw",
"on",
"the",
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"of",
"using",
"international",
"specialists",
"ia",
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"feasibility",
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"the",
"proposal",
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"fields.",
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"Those",
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"Mr",
"W.J",
"Dickson",
"Mr",
"R.L.O",
"Ely",
"Mr",
"Dr.",
"G.",
"Stungis,",
"Brown",
"&",
"Williamson",
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524860047+-0116-60.layout.json
|
[
"Program",
"and",
"Abstracis",
"11:15",
"AM",
"WEDNESDAY",
"70.",
"THE",
"NUMERICAL",
"ANALYSIS",
"OF",
"PARTICLE",
"DEPOSITION",
"IN",
"ACETATE",
"FILTERS,",
"Michihiro",
"Inagaki,",
"Tobacco",
"Science",
"Research",
"Center,",
"JAPAN",
"TOBACCO",
"INC.",
"6-2,",
"Umegaoka,",
"Aoba-ku,",
"Yokohama,",
"Kanagawa",
"227-8512,",
"JAPAN,",
"The",
"effects",
"of",
"filter",
"length,",
"fiber",
"diameter,",
"packing",
"fraction",
"and",
"flow",
"rate",
"on",
"the",
"filtration",
"efficiercy",
"in",
"the",
"fibrous",
"filter",
"have",
"been",
"clarified",
"by",
"some",
"investigators.",
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"the",
"effects",
"of",
"fiber",
"crimp",
"and",
"fiber",
"cross",
"sectional",
"shape",
"on",
"the",
"filtration",
"efficiency",
"of",
"acetate",
"filters",
"were",
"indistinct,",
"so",
"we",
"used",
"the",
"effective",
"fiber",
"length",
"and",
"the",
"effective",
"fiber",
"diameter",
"as",
"the",
"correction",
"factors.",
"In",
"this",
"study,",
"in",
"order",
"to",
"clarify",
"the",
"effect",
"of",
"fiber",
"crimp",
"and",
"fiber",
"cross",
"sectional",
"shape",
"on",
"filtration",
"efficiency",
"theoretically,",
"the",
"particle",
"depositions",
"were",
"caleulated",
"by",
"using",
"a",
"numerical",
"analysis",
"method.",
"Three-dimensional",
"geometry",
"models",
"of",
"fiber",
"crimps",
"and",
"fiber",
"cross",
"sectional",
"shapes",
"were",
"used",
"to",
"evaluate",
"the",
"particle",
"depositions.",
"the",
"mass",
"and",
"momentum",
"conservation",
"equations",
"were",
"solved",
"to",
"analyze",
"the",
"stream",
"around",
"the",
"fiber,",
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"the",
"convection-diffusion",
"equation",
"and",
"the",
"particulate",
"trajectory",
"were",
"analyzed",
"to",
"evaluate",
"the",
"deposition",
"by",
"diffusion",
"and",
"interception",
"respectively.",
"To",
"confirm",
"the",
"accuracy",
"of",
"the",
"numerical",
"calculations,",
"the",
"filtration",
"efficiencies",
"of",
"the",
"acetate",
"filters",
"were",
"measured",
"by",
"using",
"PSL",
"standard",
"particles",
"while",
"varying",
"both",
"the",
"fiber",
"diameters",
"and",
"the",
"packing",
"fractions.",
"The",
"theoretical",
"calculations",
"were",
"in",
"good",
"agreement",
"with",
"the",
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"results",
"over",
"a",
"wide",
"range",
"of",
"particle",
"diameters",
"and",
"flow",
"rates,",
"11:35",
"aM",
"ADJOURN",
"WEDNESDAY",
"MORNING,",
"SEPTEMBER",
"27,",
"2000",
"SESSION",
"B",
"SESSIONS",
"CHAIR:",
"TERESA",
"LANCE",
"9:15",
"aM",
"'WEDNESDAY",
"71,",
"COMPARISIONS",
"OF",
"VOLATILE",
"COMPONENTS",
"IN",
"LAMINA",
"AND",
"MIDRIB",
"OF",
"FLUE-CURED",
"TOBACCO",
"LEAVES",
"BY",
"CURIE-POINT",
"PYROLYZER",
"AND",
"PURGE",
"&",
"TRAP",
"GC/MSD.",
"lae",
"G,",
"Lee,",
"Hee",
"].",
"Jang,",
"Jae",
"J.",
"Kwag",
"and",
"Dong",
"W.",
"Lee,",
"Korea",
"Ginseng",
"&",
"Tobacco",
"Research",
"Institute,",
"#",
"302,",
"Shinsung,",
"Yusung,",
"Tacjon,",
"Korea,",
"305-345,",
"This",
"study",
"was",
"conducted",
"to",
"evaluate",
"the",
"differences",
"in",
"volatile",
"pyrolysis",
"products",
"between",
"lamina",
"and",
"midrib",
"of",
"flue-cured",
"tobacco",
"leaves.",
"The",
"lamina",
"and",
"midrib",
"of",
"flue-cured",
"tobacco",
"leaves",
"were",
"pyrolyzed",
"at",
"420°C,",
"650°C",
"and",
"920°C",
"by",
"Curie-Point",
"Pyrolyzer.",
"Forty-six",
"compounds",
"were",
"identified",
"as",
"volatile",
"pyrolysis",
"products",
"by",
"GC/MSD.",
"For",
"analysis",
"of",
"volatile",
"compounds,",
"the",
"Purge",
"and",
"Trap",
"headspace",
"technique",
"was",
"used.",
"This",
"approach",
"was",
"accomplished",
"by",
"purging",
"the",
"lamina",
"and",
"midrib",
"of",
"flue-cured",
"tobacco",
"leaves",
"with",
"nitrogen",
"and",
"trapping",
"the",
"%",
"52486",
"0107"
] |
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"flavor",
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"I",
"want",
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"you",
"would",
"further",
"develop",
"methods",
"for",
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"R,",
"B.",
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"£",
"3",
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[
"11/907/95",
"16:00",
"B202",
"637",
"1503",
"PHILIP",
"MORRIS",
"CO",
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"APPENDIX",
"A",
"—",
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"HEART",
"DISEASE",
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"of",
"the",
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"of",
"the",
"passive",
"smoking",
"debate",
"has",
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"on",
"lung",
"cancet",
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"significant",
"risk",
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"platelets",
"to",
"aggregate,",
"thereby",
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"oxygen",
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"rate",
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"a",
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"level",
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"must",
"increase",
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"same",
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"is",
"estimated",
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"about",
"1.7.'%",
"As",
"is",
"the",
"case",
"with",
"lung",
"cancer,",
"the",
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"similarities",
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"mainstream",
"and",
"sidestream",
"smoke",
"and",
"the",
"association",
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"active",
"smoking",
"with",
"lung",
"cancer",
"are",
"reasons",
"for",
"a",
"possible",
"relationship",
"between",
"ETS",
"and",
"lung",
"cancer,",
"which",
"should",
"be",
"teated",
"for",
"using",
"statistical",
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"studies",
"of",
"ETS",
"and",
"heart",
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"which",
"also",
"typically",
"use",
"marriage",
"ro",
"2",
"smoker",
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"a",
"measure",
"of",
"exposure,",
"are,",
"however,",
"more",
"limited",
"in",
"quality",
"and",
"quantity",
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"the",
"studies",
"of",
"ETS",
"lung",
"cancer.",
"They",
"are",
"99",
"(7.5,",
"Dept.",
"of",
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"and",
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"Services,",
"1983.",
"1%",
"155,",
"Dept.",
"of",
"Heslth",
"and",
"Humen",
"Service.",
"The",
"Health",
"Consequences",
"of",
"Smoking:",
"Cardiovascular",
"Disease.",
"A",
"Report",
"of",
"the",
"Surgeon",
"General.",
"US.",
"DHHS,",
"Public",
"Health",
"Service,",
"Offies",
"of",
"tho",
"Assistant",
"Secretary",
"of",
"Heslth,",
"Washingten,",
"DG,",
"1863,",
"DHHS",
"Pub.",
"No.",
"{PHS)",
"84-",
"50204",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.-",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"@oz23:039",
"€€9L059F0¢"
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504221516_504221531-11.layout.json
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"mouse",
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"J.",
"Virol,",
"Meth.",
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"Virol.",
"80:315-332,",
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"analysis.",
"Arch.",
"Virol,",
"80:333-347,",
"1984,",
"Levy,",
"GA,",
"Shaw,",
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"Letbowitz,",
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"E:",
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"Val,",
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"Virology",
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"Virology",
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"Aspects",
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"ASM",
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"Fung,",
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"Leibowtiz,",
"JL,",
"Cole,",
"EH,",
"Chung,",
"S,",
"Crow,",
"A,",
"and",
"Levy,",
"GA:",
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"5",
"unique:",
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"Procoagulant",
"activity",
"induced",
"by",
"murine",
"hepatitis",
"virys",
"strain",
"3",
"infection.",
"J,",
"Bigf,",
"Chem,,",
"in",
"press,",
"Chung,",
"S.,",
"Sinclair,",
"S,",
"Leibowitz,",
"JL,",
"Skameae,",
"E,",
"Fung,",
"LS,",
"and",
"Levy,",
"GA:",
"Cellular",
"and",
"metabolic",
"requirements",
"for",
"induction",
"of",
"macrophage",
"procoagulant",
"activity",
"by",
"murine",
"hepatitis",
"Virus",
"strain",
"3",
"in-vitro.",
"J.",
"Immunol,",
"146:271-278,",
"1991,",
"40040840"
] |
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501302256_501302323-59.layout.json
|
[
"SUPERVISOR'S",
"INSTRUCTIONS",
"COMMUNICATION",
"TEST",
"BMR",
"#47-810",
"Cities",
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"Baltimore,",
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"before",
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"is",
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"Total",
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"_",
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"Quota",
"_",
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"18",
"19",
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"_",
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"19",
"19",
"150*",
"*75",
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"19",
"18",
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"_19",
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"five",
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"Qualifications",
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"211",
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"18",
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"any",
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"member)",
"a",
"marketing",
"research",
"company,",
"an",
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"a",
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"&",
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"study",
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"the",
"past",
"six",
"months.",
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"card,",
"the",
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"Job",
"#",
"2)",
"City",
"3)",
"Nane",
"4)",
"Total",
"Hours",
"on",
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"5)",
"Day",
"of",
"Week",
"6)",
"Date",
"7)",
"Time",
"on",
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"Circle",
"all",
"that",
"apply.",
"CETOS",
"s5lee"
] |
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] |
1001906922.layout.json
|
[
"To:",
"From:",
"Subject:",
"/=323",
"PHILIP",
"MORRIS",
"INCORPORATED",
"INTER-OFFICE",
"CORRESPONDENCE",
",",
"@K",
"RICHMOND,",
"VIRGINIA",
"Dr.",
"R.",
"N.",
"DuPuis",
"Date:",
"March",
"5,",
"1958",
"R.",
"C.",
"Sproull",
"Filter",
"Development",
"I",
"have",
"just-recieved",
"a",
"telephone",
"call",
"from",
"Dr.",
"Jack",
"Davis",
"of",
"the&ghfimstggpq/Corporation",
"in",
"Decatur,",
"Alabama.",
"I",
"had",
"previously",
"been",
"briefly",
"associated",
"with",
"Dr.",
"Davis",
"when",
"he",
"was",
"at",
"Calloway",
"Mills",
"at",
"La",
"Grange,",
"Georgia.",
"Dr.",
"Davis",
"indicated",
"that",
"they",
"are",
"quite",
"eager",
"to",
"work",
"with",
"us",
"1in",
"developing",
"new",
"fibers",
"particularly",
"for",
"filter",
"use.",
"He",
"also",
"gave",
"me",
"some",
"confidential",
"information",
"about",
"a",
"new",
"which",
"Chemstrand",
"has",
"that",
"may",
"allow",
"us",
"to",
"incresse",
"the",
"surface",
"area",
"of",
"the",
"filter",
"markedly",
"and",
"introduce",
"a",
"new",
"chemical",
"feature",
"in",
"filtration.",
"He",
"is",
"to",
"send",
"us.",
"samples",
"of",
"their",
"conventional",
"fibers.",
"I",
"plan",
"to",
"consult",
"with",
"him",
"while",
"at",
"the",
"Textile",
"Research",
"Institute",
"\"shindig\"",
"next",
"week",
"in",
"New",
"York.",
"He",
"promised",
"to",
"show",
"me",
"at",
"that",
"time",
"photographs",
"and",
"other",
"information",
"pertaining",
"to",
"this",
"new",
"development.",
"I",
"am",
"confldent",
"that",
"Dr.",
"Davis",
"would",
"not",
"mislead",
"us",
"into",
"belleving",
"falsely",
"concerning",
"his",
"material.",
"We",
"will,",
"of",
"course,",
"have",
"to",
"keep",
"confldential",
"anything",
"that",
"we",
"learn",
"pertaining",
"to",
"their",
"development",
"work.",
"rcs/hj",
"cc:",
"Mr.",
"A.",
"P.",
"Super",
"226906",
"T00T"
] |
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2046807567_7643-1.layout.json
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[
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"Smoke",
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2060011567.layout.json
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[
"14",
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"Way",
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"Accomplishing",
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"Purposes",
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"is",
"another,",
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"day",
"of",
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"month.",
"4,",
"From",
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"a",
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"even",
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"make",
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"6.",
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"all",
"or",
"most",
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"the",
"Step",
"2.",
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2046807567_7643-73.layout.json
|
[
"18:05",
"2202",
"637",
"1505",
"PHILIP",
"MORRIS",
"CQ",
"CRS-73",
"Some",
"of",
"the",
"studies",
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"retrospective",
"recall",
"of",
"smoking",
"habits",
"or",
"incidence",
"of",
"symptoms.",
"One",
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"see",
"why",
"it",
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"be",
"difficult",
"to",
"assess",
"studies",
"that",
"are",
"so",
"diverse",
"in",
"the",
"types",
"of",
"limitations.",
"While",
"most",
"of",
"thege",
"studies",
"found",
"some",
"effects,",
"most",
"of",
"the",
"studies",
"also",
"suffered",
"from",
"some",
"limitations",
"arising",
"from",
"study",
"design.",
"Woere",
"one",
"to",
"consider",
"the",
"larger",
"body",
"of",
"research",
"on",
"acute",
"respiratory",
"illnesses,",
"a",
"different",
"set",
"of",
"problems",
"might",
"be",
"identified",
"—",
"for",
"example,",
"misclassification",
"is",
"less",
"likely",
"to",
"be",
"a",
"problem",
"since",
"these",
"studies",
"were",
"largely",
"focused",
"on",
"young",
"children,",
"but",
"confounders",
"such",
"as",
"income",
"level",
"and",
"prenatal",
"smoking",
"might",
"be",
"more",
"serious.",
"It",
"is",
"also",
"difficult",
"to",
"translate",
"these",
"findings",
"into",
"risk",
"assessments.",
"For",
"example,",
"the",
"EPA",
"report",
"limited",
"its",
"estimates",
"to",
"acute",
"respiratory",
"disorders",
"and",
"asthma,",
"because",
"of",
"the",
"difficulties",
"of",
"quantifying",
"conditions",
"such",
"as",
"coughing",
"and",
"reduced",
"lung",
"function.",
"For",
"asthma,",
"the",
"EPA’s",
"base",
"case",
"attributed",
"7",
"to",
"9",
"percent",
"of",
"new",
"cases",
"8,000",
"to",
"26,000",
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"—",
"to",
"ETS,",
"but",
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"that",
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"is",
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"the",
"conclusion",
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"a",
"risk",
"factor",
"for",
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"a",
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"model.",
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"about",
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"18",
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"2",
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"symptoms;",
"this",
"estimate",
"included",
"an",
"extrapolation",
"for",
"background",
"exposure.",
"There",
"was",
"no",
"quantification",
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"how",
"much",
"exacerbation",
"oceurred.",
".",
"In",
"the",
"case",
"of",
"acute",
"respiratory",
"illness,",
"the",
"EPA",
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"that",
"300,000",
"cases",
"are",
"due",
"to",
"ETS,",
"with",
"7,500",
"to",
"15,000",
"hospitalizations.",
"These",
"egtimates",
"were",
"confined",
"to",
"effects",
"for",
"children",
"under",
"18",
"months.",
"As",
"noted",
"earlier,",
"it",
"is",
"likely",
"that",
"much",
"of",
"the",
"exposure",
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"ETS,",
"especially",
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"young",
"children,",
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"to",
"exposures",
"in",
"the",
"home",
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"regulation",
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"an",
"effect,",
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"any",
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"concentrate",
"an",
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"While",
"ETS",
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"pose",
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"in",
"the",
"home,",
"such",
"education",
"programs",
"would",
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"be",
"most",
"effective",
"by",
"emphasizing",
"all",
"of",
"the",
"risks",
"resulting",
"from",
"parent’s",
"behavior",
"that",
"these",
"children",
"face",
"in",
"that",
"environment.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"Q036038",
"0V9L089%0¢%"
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508939370_508939517-69.layout.json
|
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0060251509.layout.json
|
[
"A",
"AMERICAN",
"SRANOE,ING.",
"T",
"/",
"CONFIDENTIAL",
"O",
"Mr,",
"R",
"7",
"President.",
"and",
"Chief",
"Operating",
"Officer",
"2",
"s",
".",
"g",
"Johr",
"H.",
"HageT,",
"Research",
"and",
"Development",
"Director",
"flfl",
"sl",
"F|",
"Hanmer",
"Division",
"Formula",
"Changes",
"Reconstituted",
"Tobacco,",
"Cigarettes",
"This",
"supplements",
"my",
"memorandum",
"to",
"you",
"of",
"January",
"10,",
"1972,",
"requesting",
"autnority",
"for",
"formula",
"adjustments",
"in",
"our",
"cigarette",
"grade",
"reconstituted",
"tobaccos",
"due",
"to",
"changing",
"availability",
"and",
"inventory",
"durations",
"of",
"certain",
"input",
"tobacco",
"by-product",
"materials.",
"e",
"©o",
"a",
"large",
"survlus",
"of",
"tobacco",
"by-products",
"currently",
"available",
"{3rinarily",
"short",
"tobacco",
"from",
"reclaiming",
"operations",
"known",
"as",
"\"shorts\")",
"f",
"or",
"regular",
"factory",
"operations",
"and",
"our",
"Service",
"Department",
"operation,",
"we",
"recommend",
"tihe",
"following:",
"-t",
"L.",
"an",
"increase",
"from",
"up",
"to",
"3%",
"to",
"up",
"to",
"6%",
"in",
"the",
"miscellaneous",
"tobacco",
"portion",
"of",
"the",
"input",
"blend",
"for",
"RC-TM.",
"These",
"tobaccos",
"are",
"used",
"as",
"extenders",
"to",
"the",
"basic",
"formula,",
"thus",
"reducing",
"all",
"other",
"components",
"by",
"a",
"like",
"percentage.",
"This",
"recommended",
"increase",
"will",
"accomodate",
"regular",
"(no",
"menthol",
"or",
"little",
"cigar)",
"\"shorts\"",
"from",
"cigarettes",
"in",
"addition",
"to",
"the",
"current",
"up",
"to",
"3%",
"portion",
"which",
"accomodates",
"menthol",
"“\"shorts\"",
"and",
"Fines",
"A",
"and",
"Nashville",
"Branch",
"stems",
"which",
"still",
"have",
"a",
"considerable",
"amount",
"of",
"lamina",
"attached",
"after",
"processing.",
"2.",
"the",
"application",
"of",
"the",
"use",
"of",
"miscellaneous",
"tobaccos",
"as",
"extenders",
"to",
"the",
"RC-I",
"formula",
"in",
"the",
"amount",
"of",
"up",
"to",
"6%.",
"3.",
"an",
"increase",
"from",
"2%",
"to",
"4%",
"in",
"factory",
"slivers",
"(stems",
"C)",
"with",
"a",
"corresponding",
"decrease",
"in",
"2%",
"flue",
"cured",
"stems",
"in",
"the",
"RC~TM",
"formula.",
"The",
"formula",
"adjustments",
"we",
"describe",
"above",
"should",
"have",
"little,",
"if",
"any,",
"effect",
"upon",
"the",
"overall",
"taste",
"and",
"physical",
"properties",
"of",
"our",
"reconstituted",
"obaccos.",
"These",
"will",
"be",
"a",
"considerable",
"help",
"in",
"keeping",
"current",
"with",
"by-products",
"generation",
"without",
"hurting",
"our",
"reconstituted",
"products.",
"We",
"have",
"declined",
"to",
"recommend",
"the",
"use",
"of",
"any",
"factory",
"generated",
"little",
"clgar",
"as",
"we",
"feel",
"these",
"would",
"have",
"detrimental",
"effect.",
"Accounting",
"values",
"have",
"been",
"established",
"with",
"Mr.",
"Vehslage,",
"and",
"the",
"net",
"effect",
"for",
"Hanmer",
"Division",
"will",
"be",
"a",
"slight",
"reduction",
"in",
"per",
"pound",
"costs,.",
"‘lay",
"we",
"have",
"your",
"approval",
"to",
"proceed",
"with",
"1,",
"2",
"and",
"3",
"above.",
"oty",
"cc:",
"Mr.",
"H.,",
"P.",
"Vehslage,",
"Controller",
"Manufacture",
"and",
"Leaf"
] |
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2076716849b_6850-0.layout.json
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"TO",
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"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"L6SLO8IVOT"
] |
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80228906_80228935-26.layout.json
|
[
"8.5",
"PROTOCOL",
"1601.401",
"(I-5026.401)",
"Enzyme",
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"The",
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"reactions",
"will",
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"used",
"to",
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"enzyme",
"activity:",
"8.5.1",
"p-Nitroanisole",
"O-demethylase",
"(PNAS)",
"PNAS",
"activity",
"will",
"be",
"determined",
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"to",
"the",
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"of",
"Thurman",
"et",
"al.,",
"(1977)",
"with",
"modification.",
"Microsomal",
"protein",
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"will",
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"NADPH,",
"10",
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"MgClz,",
"and",
"0.2",
"M",
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"pH",
"7.4.",
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"15",
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"the",
"reaction",
"is",
"stopped",
"with",
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"acid",
"and",
"the",
"amount",
"of",
"p-nitrophenol",
"is",
"determined",
"spectro-",
"photometrically",
"at",
"436",
"nm.",
"‘",
"8.5.2",
"T-Ethoxycoumarin",
"O-deethylase",
"(7EC)",
"TEC",
"activity",
"will",
"be",
"determined",
"using",
"the",
"method",
"of",
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"Poland",
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"0.3",
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"protein",
"will",
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"0.5",
"umole",
"of",
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"in",
"the",
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"of",
"0.5",
"umole",
"NADPH,",
"0.5",
"umole",
"NADH,",
"5",
"umole",
"MgCl.,,",
"and",
"65",
"umole",
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"7.4",
"for",
"20",
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"reaction,",
"the",
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"7-hydroxycoumarin,",
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"an",
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"wavelength",
"of",
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"emission",
"wavelength",
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"455",
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"8.5.3",
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"125",
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"NADPH,",
"25",
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"MgCl,,",
"and",
"0.05",
"M",
"Tris",
"buffer",
"at",
"pH",
"7.5.",
"The",
"amount",
"of",
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"produced",
"is",
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"at",
"an",
"excitation",
"wavelength",
"of",
"522",
"nm",
"and",
"emission",
"wavelength",
"of",
"586",
"nm",
"after",
"a",
"3",
"minute",
"incubation.",
"Enzyme",
"activity",
"will",
"be",
"determined",
"in",
"vitro",
"using",
"microsomal",
"suspensions",
"from",
"individual",
"rat",
"livers.",
"Activity",
"will",
"be",
"expressed",
"as",
"product",
"formed/mg",
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"protein/hour",
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"A",
"positive",
"control",
"will",
"be",
"assayed",
"with",
"each",
"group",
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"samples,",
"This",
"positive",
"control",
"will",
"consist",
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"a",
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"suspension",
"2£682208",
"r"
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509790579+-0598-1.layout.json
|
[
"EUROPEAN",
"COMMUNITIES",
"November",
"deadline",
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"paper",
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"European",
"Commission's",
"DG",
"111",
"is",
"now",
"saying",
"it",
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"to",
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"the",
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"the",
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"general",
"food",
"divective",
"until",
"November",
"The",
"deputy",
"head",
"of",
"unit.",
"Bob",
"Hankin,",
"10ld",
"EC",
"Food",
"Law",
"that",
"more",
"work",
"was",
"still",
"needed",
"to",
"make",
"the",
"green",
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"more",
"comprehensible,",
"particularly",
"to",
"people",
"who",
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"not",
"have",
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"\"The",
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"it",
"easier",
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"he",
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"will",
"also",
"be",
"affected",
"by",
"the",
"time",
"taken",
"to",
"wranslate",
"all",
"50",
"pages",
"of",
"it",
"into",
"the",
"nine",
"community",
"languages",
"There",
"is",
"often",
"a",
"backlog",
"in",
"the",
"Commission's",
"translation",
"service",
"owards",
"the",
"end",
"of",
"a",
"Commission's",
"mandate.",
"The",
"green",
"paper",
"could",
"face",
"further",
"delays",
"because",
"it",
"will",
"be",
"due",
"out",
"within",
"a",
"month",
"or",
"two",
"of",
"a",
"new",
"Commission",
"being",
"appointed.",
"The",
"green",
"paper",
"is",
"expected",
"to",
"include:",
"*",
"General",
"definitions",
"for",
"all",
"food",
"law",
"and",
"create",
"some",
"new",
"definitions.",
"for",
"example,",
"a",
"definition",
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"General",
"principles",
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"safety.",
"fair",
"trade.",
"producer",
"responsibility,",
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"risk",
"and",
"scrious",
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">",
"The",
"transposition",
"of",
"directives",
"into",
"national",
"law",
"*",
"The",
"adapration",
"to",
"technical",
"progress",
"*",
"Coherence",
"It",
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"at",
"existing",
"texts",
"and",
"problem",
"areas",
"such",
"as",
"hygicone.",
"But",
"11",
"does",
"not",
"make",
"recommendations",
"on",
"hygiene",
"legislation",
"because",
"this",
"will",
"be",
"covered",
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"a",
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"Parliament",
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"1996",
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"inter-service",
"consultation",
"within",
"the",
"Commission",
"on",
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"and",
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"15",
"likely",
"to",
"be",
"consultation",
"with",
"interesied",
"pariics",
"in",
"the",
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"weeks",
"Revisions",
"to",
"verticals",
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"revised",
"text",
"on",
"the",
"mineral",
"waters",
"directive",
"could",
"be",
"adopted",
"by",
"the",
"European",
"Commission",
"by",
"the",
"end",
"of",
"September,",
"according",
"to",
"DG",
"Il",
"sources,",
"But",
"there",
"will",
"be",
"longer",
"delays",
"on",
"the",
"other",
"seven",
"texts",
"(fruit",
"juice,",
"chocolate.",
"sugar.",
"jams,",
"honey.",
"coffee,",
"dried",
"milk)",
"which",
"are",
"still",
"in",
"the",
"\"final",
"stages”",
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"interservice",
"consultation,",
"Mincral",
"waters",
"1s",
"being",
"dealt",
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"because",
"it",
"is",
"considered",
"to",
"be",
"a",
"mare",
"technical",
"revision",
"than",
"the",
"other",
"texts",
"It",
"is",
"up",
"for",
"DG",
"IlI's",
"Commissianer",
"Martin",
"Bangemann",
"to",
"decide",
"whether",
"the",
"revised",
"texis",
"should",
"be",
"adopted",
"via",
"the",
"written",
"procedure",
"or",
"a",
"full",
"Commussion",
"meeting.",
"As",
"some",
"of",
"the",
"seven.",
"such",
"as",
"chocolate,",
"are",
"controversial",
"within",
"the",
"Commission.",
"raising",
"issues",
"about",
"developing",
"countries",
"as",
"well",
"as",
"the",
"single",
"market,",
"these",
"could",
"go",
"to",
"a",
"Commission",
"meeting.",
"Unit",
"pricing",
"The",
"Consumer",
"Policy",
"Service",
"(CPS)",
"was",
"preparing",
"10",
"send",
"out",
"its",
"sccond",
"draft",
"on",
"a",
"new",
"proposal",
"on",
"unit",
"pricing",
"as",
"EC",
"Food",
"Law",
"went",
"to",
"press.",
"The",
"official",
"in",
"charge,",
"Marc",
"Jeumaux.",
"said",
"the",
"second",
"draft",
"was",
"not",
"radically",
"different",
"to",
"the",
"first",
"(see",
"EC",
"Food",
"Law",
"July",
"1994)",
"but",
"was",
"aimed",
"at",
"meenting",
"concerns",
"raised",
"during",
"consultations.",
"There",
"would",
"be",
"two",
"possibilities",
"for",
"exempting",
"retailers",
"from",
"unit",
"pricing",
"goods,",
"which",
"involves",
"indicating",
"comparatively",
"the",
"cost",
"per",
"kilo",
"or",
"htre.",
"The",
"first",
"exemption",
"would",
"be",
"for",
"products",
"where",
"such",
"comparisons",
"were",
"\"meaningless”",
"and",
"he",
"gave",
"tables",
"or",
"chairs",
"as",
"examples",
"The",
"second",
"exemption",
"would",
"be",
"for",
"\"small",
"retalers™",
"and",
"it",
"would",
"be",
"for",
"each",
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"Statc",
"to",
"define",
"the",
"scope",
"of",
"this",
"category.",
"The",
"draft",
"would",
"break",
"the",
"link",
"in",
"present",
"directives",
"between",
"ranges",
"and",
"prices.",
"whereby",
"certain",
"products,",
"such",
"as",
"coffec,",
"are",
"exempt",
"provided",
"they",
"are",
"sold",
"in",
"prescribed",
"ranges",
"The",
"new",
"draft",
"will",
"be",
"sent",
"1o",
"industry",
"and",
"consumer",
"groups",
"as",
"well",
"as",
"other",
"directorates",
"within",
"the",
"Commission",
"“We",
"expect",
"that",
"this",
"new",
"drafl",
"is",
"the",
"right",
"onc.",
"But",
"it",
"necessary.",
"we",
"will",
"prepare",
"a",
"third.",
"We",
"won't",
"do",
"anything",
"secretive",
"we",
"will",
"consult",
"properly.”",
"said",
"Mr",
"Jeuntaux",
"Retzilers",
"have",
"complained",
"about",
"the",
"cost",
"of",
"unit",
"pricing.",
"arguing",
"that",
"for",
"supermarkets",
"it",
"could",
"work",
"out",
"at",
"£30.000",
"a",
"store",
"to",
"introduce.",
"as",
"well",
"as",
"the",
"cost",
"of",
"ecmplaying",
"more",
"staff",
"to",
"continually",
"check",
"that",
"2",
"©",
"1994",
"Agra",
"Europe",
"(Landon",
"Lid",
"E£C",
"Food",
"Law:",
"September",
"1994",
"w",
"@",
"0",
"~",
"o",
"S",
"w",
"@"
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0001007338-8.layout.json
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"of",
"a",
"light",
"paired",
"with",
"morphine",
"infusion",
"in",
"monkeys,",
"which",
"had",
"previously",
"self-administered",
"mor-",
"phine",
"on",
"a",
"variable-interval",
"schedule.",
"A",
"serics",
"of",
"24-he",
"extinction",
"tests",
"were",
"run,",
"in",
"which",
"responses",
"produced",
"the",
"light,",
"previously",
"paiced",
"with",
"morphitie,",
"on",
"a",
"variable-interval",
"schedule",
"on",
"onc",
"day,",
"while",
"on",
"alternate",
"days",
"responses",
"produced",
"no",
"consequence.",
"On",
"the",
"days",
"on",
"which",
"the",
"light",
"presented,",
"response",
"rates",
"were",
"significantly",
"higher",
"than",
"on",
"the",
"days",
"when",
"had",
"no",
"consequence.",
"Stimuli",
"paired",
"with",
"morphine",
"administration",
"also",
"came",
"to",
"influence",
"the",
"distuptive",
"effects",
"of",
"morphine",
"withdrawal",
"on",
"other",
"behaviors",
"[Thompson",
"&",
"Schuster",
"(39}].",
"Monkeys",
"were",
"conditioned",
"on",
"a",
"complex",
"multiple",
"rein:",
"forcement",
"schednle",
"to",
"obtain",
"food",
"and",
"avoid",
"shocks.",
"Tn",
"addition,",
"the",
"an",
"mals",
"self-administered",
"1",
"mg/kg",
"of",
"morphine",
"every",
"6",
"hr.",
"During",
"a",
"period",
"when",
"the",
"opportunity",
"to",
"self-administer",
"morphine",
"was",
"removed,",
"the",
"food-",
"reinforeed",
"and",
"shock-avoidance",
"behaviors",
"progressively",
"deteriorated.",
"A",
"sin-",
"gle",
"morphine",
"self-administration",
"reinstated",
"these",
"behiaviors.",
"In",
"a",
"replication",
"of",
"this",
"procedre,",
"the",
"animals",
"were",
"allowed",
"to",
"self-administer",
"saline",
"accont-",
"panied",
"by",
"&",
"light",
"which",
"had",
"previously",
"been",
"paired",
"with",
"morphine",
"infusion.",
"There",
"was",
"a",
"temporary",
"tecovery",
"of",
"the",
"food-reinforced",
"and",
"shock-avoid-",
"ance",
"behaviors,",
"Thus,",
"the",
"ameliorative",
"effects",
"of",
"morphine",
"had",
"hecome",
"con-",
"ditioned",
"to",
"the",
"light",
"paired",
"with",
"morphine",
"infusion.",
"Wikler",
"(105)",
"suggested",
"that",
"withdrawal",
"symptoms",
"may",
"become",
"condi-",
"tioned,",
"and",
"might",
"influence",
"the",
"subsequent",
"disposition",
"to",
"take",
"drugs.",
"The",
"fact",
"that",
"certain",
"withdrawal",
"symptoms",
"can",
"be",
"conditioned",
"now",
"seems",
"clear,",
"however,",
"it",
"is",
"not",
"evident",
"what",
"role",
"this",
"might",
"play",
"in",
"self-administration.",
"Wikler",
"&",
"Pescor",
"(106)",
"placed",
"rats",
"in",
"an",
"environment",
"in",
"which",
"they",
"had",
"previously",
"experienced",
"withdrawal,",
"and",
"observed",
"abstinence",
"signs.",
"The",
"number",
"of",
"“wet",
"dog”",
"shakes",
"(=",
"sign",
"of",
"acute",
"withdrawal",
"distress",
"in",
"rats)",
"was",
"significantly",
"higher",
"in",
"rats",
"that",
"had",
"experienced",
"withdrawal",
"in",
"the",
"enviconment",
"than",
"it",
"was",
"in",
"controls.,",
"Goldherg",
"&",
"Schuster",
"(107)",
"demon-",
"strated",
"that",
"a",
"stimulus",
"paired",
"with",
"nalorphine",
"infusion",
"in",
"physically-",
"cependent",
"monkeys,",
"elicits",
"withdrawal",
"symptoms.",
"Monkeys",
"working",
"for",
"food",
"an",
"&",
"fixed-ratio",
"schedule",
"were",
"presented",
"with",
"a",
"S-min",
"tone",
"fallowed",
"by",
"an",
"infusion",
"of",
"nalorphine.",
"After",
"several",
"sessions",
"of",
"pairings,",
"the",
"anset",
"of",
"the",
"tone",
"was",
"fallowed",
"by",
"complete",
"suppression",
"of",
"the",
"operant",
"re~",
"sponding.",
"In",
"addition,",
"signs",
"of",
"acute",
"withdrawal",
"distress,",
"including",
"saliva-",
"tion",
"and",
"vomiting",
"occurred",
"during",
"the",
"tone.",
"Behovioral",
"dependence—Behavioral",
"dependence",
"always",
"accompanies",
"physical",
"dependence,",
"in",
"that",
"discontinuation",
"of",
"chronic",
"drug",
"treatment",
"pro-",
"duces",
"behavioral",
"as",
"well",
"as",
"physiological",
"disruptions.",
"Thompson",
"&",
"Schuster",
"(39)",
"found",
"that",
"food-reinforced",
"and",
"shock-avoidance",
"bebaviors",
"were",
"dis-",
"rupted",
"during",
"withdrawal",
"(after",
"about",
"18",
"hr)",
"and",
"were",
"reinstated",
"when",
"torphine",
"was",
"administered.",
"Djahanguiri,",
"Richelle",
"&",
"Fontaine",
"(108)",
"re-",
"SELF",
"ADMINISTRATION",
"OF",
"DRUGS",
"499",
"ported",
"disruptive",
"effects",
"of",
"morphine",
"withdrawat",
"on",
"food-reinforced",
"fixed-",
"interval",
"performance",
"by",
"cats.",
"After",
"6",
"weeks",
"of",
"daily",
"subculan?nuu",
"mor-",
"phine",
"(0.2",
"mg/kg)",
"onc",
"out",
"of",
"three",
"cats",
"showed",
"total",
"suppression",
"of",
"the",
"operant.",
"Seven",
"more",
"weeks",
"of",
"drug",
"administration,",
"followed",
"by",
"cessation",
"of",
"treatment,",
"produced",
"complete",
"disruption",
"of",
"operant",
"performance",
"in",
"the",
"re-",
"maining",
"two",
"animals.",
"Behavioral",
"dependence",
"without",
"physical",
"dependence",
"has",
"been",
"reported",
"with",
"d-amphetamine",
"and",
"chlorpromazine.",
"Schuster,",
"Dockens",
"&",
"Woods",
"(109)",
"investigated",
"the",
"effects",
"of",
"chronic",
"administration",
"of",
"d-amphetamine",
"in",
"rats",
"trained",
"on",
"a",
"shock-avoidance",
"schedule.",
"Before",
"beginning",
"drug",
"ad-",
"ministration,",
"the",
"number",
"of",
"shocks",
"received",
"were",
"relatively",
"high",
"because",
"of",
"the",
"animals’",
"low",
"responsc",
"rates,",
"Under",
"the",
"influence",
"of",
"d-amphetamine,",
"re-",
"sponse",
"rates",
"increased",
"and",
"the",
"nuember",
"of",
"shocks",
"diminished.",
"On",
"discontin-",
"ving",
"drug",
"treatment,",
"rather",
"than",
"continuing",
"at",
"the",
"improved",
"level",
"of",
"performance",
"{which",
"was",
"more",
"effective",
"in",
"meeting",
"the",
"cnvironmental",
"con-",
"tingencies)",
"behavior",
"reverted",
"to",
"its",
"previous",
"level.",
"Waller",
"(110)",
"condi-",
"tioned",
"dogs",
"on",
"a",
"fixed-interval",
"schedule",
"of",
"food",
"reinforcement,",
"and",
"admin-",
"istered",
"chlorprumazine",
"orally",
"for",
"15",
"days.",
"Foflowing",
"discontinuation",
"of",
"drug",
"treatment,",
"disruption",
"of",
"the",
"fixed-interval",
"responding",
"ensued,",
"charac-",
"terized",
"by",
"long",
"pauses",
"and",
"extremely",
"low",
"rates.",
"Unfortunately,",
"there",
"are",
"no",
"reports",
"dealing",
"with",
"the",
"relationship",
"of",
"be-",
"havieral",
"dependence",
"to",
"the",
"scif-administration",
"of",
"a",
"drug.",
"This",
"is",
"an",
"ex-",
"tremely",
"important",
"area",
"of",
"research",
"which",
"should",
"reccive",
"the",
"attention",
"of",
"investigators",
"in",
"the",
"near",
"futurc.",
"GENERAL",
"DISCUSSION",
"The",
"importance",
"of",
"amimal",
"research",
"using",
"self-administration",
"techigues",
"is",
"based",
"largely",
"on",
"the",
"assumption",
"that",
"its",
"findings",
"will",
"have",
"relevance",
"to",
"the",
"social",
"problems",
"of",
"drug",
"abuse",
"in",
"man.",
"The",
"fact",
"that",
"many",
"of",
"the",
"drugs",
"commonly",
"abused",
"hy",
"man",
"are",
"self-administered",
"by",
"experimental",
"animals",
"lends",
"credence",
"to",
"this",
"assumption.",
"The",
"ultimate",
"vale",
"of",
"this",
"research",
"lies",
"in",
"the",
"degree",
"to",
"which",
"a",
"new",
"drag’s",
"abuse",
"potential",
"in",
"man",
"can",
"be",
"predicted",
"and",
"the",
"insights",
"gained",
"into",
"the",
"basic",
"mechanisms",
"underlying",
"the",
"self-ad-",
"ministration",
"of",
"drugs.",
"It",
"wonld",
"be",
"simplistic",
"to",
"assume",
"that",
"drugs",
"can",
"be",
"divided",
"into",
"two",
"dis-",
"linct",
"categories:",
"those",
"that",
"will",
"be",
"self-administered",
"and",
"those",
"that",
"will",
"not",
"Clearly",
"2",
"wide",
"variety",
"of",
"physiclogical",
"and",
"behavioral",
"variables",
"akter",
"a",
"drug's",
"ability",
"to",
"act",
"as",
"a",
"reinforcer.",
"There",
"is",
"no",
"experimental",
"justification",
"for",
"assuming",
"that",
"all",
"relevant",
"variables",
"will",
"act",
"alike",
"for",
"all",
"classes",
"of",
"drugs,",
"The",
"diversity",
"of",
"pharmacological",
"actions",
"exhibited",
"by",
"the",
"spectrum",
"ot",
"drugs",
"which",
"arc",
"self-administered",
"suggests",
"the",
"contrary.",
"1t",
"would",
"there-",
"fore",
"be",
"hazardous",
"to",
"conchude",
"that",
"becanse",
"an",
"animal",
"fails",
"to",
"self-adminis-",
"ter",
"o",
"drug",
"under",
"one",
"set",
"of",
"conditions",
"that",
"it",
"may",
"not",
"he",
"self-administered",
"under",
"another",
"set",
"of",
"contingencies.",
"However,",
"from",
"a",
"practical",
"viewpoint,",
"drugs",
"with",
"the",
"highest",
"abuse",
"potential",
"are",
"thase",
"which",
"have",
"properties",
"lead-",
"ing",
"to",
"their",
"self-administration",
"under",
"a",
"wide",
"varicty",
"of",
"conditions.",
"The"
] |
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] |
0001007338-3.layout.json
|
[
"405601998",
"488",
"SCHUSTER",
"&",
"THOMPSON",
"Thompson",
"&",
"Pickens",
"(35),",
"Woods",
"&",
"Schuster",
"(41),",
"have",
"confirmed",
"that",
"morphine,",
"over",
"a",
"<onsiderable",
"dosage",
"range,",
"can",
"act",
"s",
"a",
"reinforcer.",
"Deneau",
"(43)",
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"comparative",
"studies",
"of",
"self-administration",
"by",
"the",
"Rhesus",
"monkey",
"of",
"several",
"drugs",
"commonly",
"self-administered",
"by",
"humans,",
"in-",
"cluding",
"the",
"opioid",
"methadone.",
"Collins",
"&",
"Weeks",
"(40)",
"studied",
"the",
"relative",
"reinforcing",
"properties",
"of",
"intravenously",
"administered",
"codeine,",
"dihydromor-",
"phinane,",
"and",
"methadone",
"in",
"rats,",
"using",
"a",
"fixed-ratio",
"10",
"schedule",
"of",
"rein-",
"forcement.",
"Wikler",
"et",
"al,",
"(11)",
"have",
"reported",
"oral",
"setf-administration",
"of",
"the",
"opicid,",
"etanitazine,",
"by",
"rats.",
"Barbiturates",
"have",
"been",
"shown",
"to",
"be",
"self-administered",
"by",
"rats",
"under",
"cot-",
"ditions",
"of",
"intermittent",
"unavoidable",
"shocks.",
"Amobarbital",
"(Davis",
"&",
"Miller",
"(44)]",
"and",
"hexobarbital",
"[Davis,",
"Lulenski",
"&",
"Miller",
"(45))",
"were",
"self-admin-",
"istered",
"under",
"these",
"conditions,",
"Deneau",
"(43)",
"has",
"shown",
"that",
"pentobarbital",
"and",
"phenobarbital",
"are",
"self-administercd",
"by",
"naive",
"Rhesus",
"monkeys.",
"Kamano",
"&",
"Arp",
"(46)",
"reported",
"that",
"rats",
"would",
"drink",
"a",
"weak",
"chlordiazepoxide",
"salu-",
"tion;",
"however,",
"it",
"was",
"not",
"clear",
"whether",
"the",
"drug",
"was",
"serving",
"as",
"a",
"reinfore-",
"er.",
"The",
"oral",
"ingestion",
"of",
"ethyl",
"alcohol",
"has",
"been",
"demonstrated",
"to",
"be",
"a",
"rein-",
"forcer",
"for",
"a",
"lever-pressing",
"operant",
"in",
"rats",
"[Myers",
"(47),",
"Mello",
"&",
"Mendel-",
"son",
"(48)7.",
"The",
"intravenous",
"infusion",
"of",
"ethyl",
"alcohol",
"has",
"been",
"reported",
"to",
"act",
"as",
"a",
"reinforcer",
"for",
"a",
"lever-pressing",
"operant",
"in",
"Rhesus",
"monkeys",
"[Yanagita,",
"Deneau",
"&",
"Secvers",
"(28)].",
"The",
"relnforcing",
"offccts",
"of",
"stimulant",
"drugs",
"have",
"also",
"been",
"investigated.",
"Yenagita,",
"Deneau",
"&",
"Seevers",
"(28)",
"reported",
"that",
"cocaine",
"was",
"self-adminis-",
"tered",
"by",
"monkeys,",
"Similar",
"Andings",
"have",
"been",
"reported",
"by",
"Pickens",
"&",
"Thompson",
"(49,",
"50),",
"Pickens",
"(1),",
"Woods",
"&",
"Schuster",
"(41),",
"and",
"Wiison",
"&",
"Schuster",
"(52),",
"hoth",
"in",
"rats",
"and",
"monkeys.",
"Methamphetamine",
"has",
"been",
"faund",
"to",
"be",
"an",
"effective",
"reinforcer",
"in",
"rats",
"[Pickens,",
"Meisch",
"&",
"McGuire",
"(53);",
"Pickens,",
"Meisch",
"&",
"Dougherty",
"(54);",
"Pickens",
"(51)].",
"d-Amphetamine",
"is",
"self-administered",
"by",
"monkeys",
"[Deneau",
"(43)]",
"and",
"rats",
"[Pickens",
"&",
"Thompson",
"(49),",
"Pickens",
"&",
"Harris",
"(55),",
"Pickens",
"(51)].",
"Nicotine",
"is",
"self-",
"administered",
"intravenously",
"[Denean",
"&",
"Tnoki",
"(36)]",
"and",
"inbaled",
"as",
"tobacco",
"amoke",
"[Jarvik",
"(5)]",
"monkeys.",
"The",
"drug,",
"SPA",
"(1-2",
"diphenyl",
"Ldimeth-",
"yl-amino",
"ethane",
"hydrochloride),",
"which",
"is",
"of",
"considerable",
"concern",
"in",
"Japan",
"because",
"of",
"human",
"abuse,",
"is",
"also",
"self-administered",
"by",
"the",
"monkey",
"&",
"Schuster",
"(57),",
"Woods",
"&",
"Schuster",
"(41),",
"and",
"Wil-",
"son",
"&",
"Schuster",
"(52)].",
"Hitomi",
"&",
"Schuster",
"(58)",
"have",
"shown",
"that",
"Rhesus",
"monkeys",
"will",
"self-administer",
"phenmetrazine,",
"methylphenidate,",
"and",
"pipradrol",
"but",
"pemoline",
"nder",
"the",
"same",
"experimental",
"conditions.",
"Thus,",
"rats",
"and",
"monkeys",
"have",
"been",
"shown",
"to",
"self-adininister",
"represcnta-",
"tive",
"compounds",
"from",
"several",
"of",
"the",
"major",
"classes",
"of",
"drugs",
"that",
"are",
"illicitly",
"self-administered",
"by",
"man:",
"opioids",
"(morphine,",
"methadane,",
"codeine,",
"dihydro-",
"s",
"phinone,",
"etonitazine),",
"barbiturates",
"and",
"related",
"drugs",
"(amobarbital,",
"hexo-",
"Viarlital,",
"pentobarbital,",
"phenobarbital,",
"chlordiazepoxide,",
"ethyl",
"alcohol),",
"stim-",
"wlants",
"(cocaine,",
"methamphetamine,",
"d-amphetamine,",
"nicatine,",
"SPA,",
"phen-",
"metrazine,",
"methylphenidate,",
"pipradrol).",
"Under",
"similar",
"experimental",
"con",
"tlons,",
"monkeys",
"will",
"not",
"self-administer",
"nalorphine,",
"chlorpromazinz,",
"mesca-",
"SELF",
"ADMINISTRATION",
"OF",
"DRUGS",
"489",
"line",
"[Dencav,",
"Yanagita",
"&",
"Seevers",
"(59)],",
"or",
"pemoline",
"[Hitomi",
"&",
"Schu-",
"ster",
"(58)].",
"Magritude",
"of",
"drug",
"reinforcement",
"(dosage",
"per",
"infusion)—The",
"effec-",
"tiveness",
"of",
"reinforcers",
"in",
"maintaining",
"behavior",
"is",
"dependent",
"not",
"only",
"on",
"the",
"kind",
"but",
"also",
"the",
"amount.",
"It",
"is",
"known",
"that",
"both",
"the",
"initial",
"acquisition",
"and",
"subsequent",
"maintenance",
"of",
"behavior",
"varies",
"with",
"the",
"magnitude",
"of",
"rein-",
"forcement.",
"The",
"relationship",
"between",
"rate",
"of",
"responding",
"and",
"reinforcement",
"tmagnitude",
"varies",
"with",
"the",
"reinforcer,",
"Several",
"investigators",
"have",
"explored",
"the",
"role",
"of",
"drug",
"reinforcement",
"magnitude",
"in",
"maintaining",
"conditioned",
"oper-",
"ants.",
"Wecks",
"(30),",
"Weeks",
"&",
"Callins",
"(39),",
"and",
"Collins",
"&",
"Weeks",
"(40)",
"found",
"that",
"the",
"rate",
"of",
"marphine-reinforced",
"lever-pressing",
"on",
"low",
"ratio",
"schedules",
"was",
"inversely",
"related",
"to",
"dosage,",
"in",
"the",
"range",
"of",
"3.2",
"to",
"10.0",
"mg/kg",
"per",
"infu-",
"sion.",
"Woods",
"&",
"Schuster",
"(41),",
"using",
"Rhesus",
"monkeys,",
"have",
"found",
"that",
"re-",
"spanse",
"rate",
"on",
"a",
"variable-interval",
"schedule",
"varies",
"in",
"an",
"inverted",
"“U\"",
"shaped",
"manner",
"with",
"morphine",
"reinforcement",
"magnitude",
"in",
"the",
"range",
"10",
"to",
"1000",
"ug/ke",
"per",
"infusion,",
"A",
"number",
"of",
"investigators",
"have",
"examined",
"the",
"oral",
"ingestion",
"of",
"alcohol",
"as",
"a",
"function",
"of",
"concentration,",
"Myers",
"&",
"Carey",
"(60}",
"described",
"a",
"method",
"for",
"determining",
"a",
"preference",
"threshold",
"for",
"alcohol",
"relative",
"to",
"water.",
"In",
"this",
"procedure",
"rats",
"pressed",
"one",
"iever",
"for",
"alcohol",
"or",
"ancther",
"for",
"water.",
"The",
"number",
"of",
"lever",
"responses",
"for",
"water",
"and",
"alcoho!",
"were",
"recorded",
"when",
"dif-",
"ferent",
"concentrations",
"of",
"alcohol",
"were",
"tested",
"in",
"successive",
"sessions,",
"This",
"method",
"allows",
"the",
"determination",
"of",
"the",
"concentration",
"of",
"alcohol",
"which",
"is",
"discriminable",
"from",
"water",
"(in",
"rats",
"about",
"3",
"to",
"4",
"per",
"cent)",
"as",
"well",
"as",
"the",
"maximum",
"preference",
"threshold,",
"which",
"is",
"defined",
"as",
"the",
"concentration",
"at",
"which",
"the",
"aleohol-ntake",
"curve",
"crosses",
"the",
"water-intake",
"curve,",
"Myers",
"(17)",
"discusses",
"the",
"advantage",
"of",
"this",
"procedure",
"relative",
"to",
"the",
"use",
"of",
"single",
"con-",
"centrations",
"of",
"aleohol",
"for",
"a",
"determination",
"of",
"changes",
"in",
"alcoho!",
"preference.",
"Deneau",
"&",
"Inoki",
"(56)",
"reported",
"an",
"inverse",
"relationship",
"between",
"the",
"num-",
"ber",
"of",
"intravenous",
"nicotine",
"self-infusions",
"by",
"Rhbesus",
"monkeys",
"and",
"dosages",
"per",
"infusion.",
"Pickens",
"&",
"Thompson",
"(49,",
"50),",
"Pickens",
"&",
"Harris",
"(55),",
"and",
"Pickens,",
"Meisch",
"&",
"McGuire",
"(53),",
"found",
"there",
"is",
"an",
"inverse",
"relation",
"between",
"response",
"rate",
"and",
"reinforcement",
"magnitude",
"across",
"all",
"self-administered",
"dosages",
"of",
"methamphetamine,",
"d-amphetamine",
"and",
"cocaine.",
"Similar",
"relations",
"have",
"been",
"found",
"using",
"monkeys",
"and",
"the",
"stimulants",
"SPA",
"and",
"cocaine",
"[Woods",
"&",
"Schuster",
"(41),",
"Wilson",
"&",
"Schuster",
"(52)];",
"phenmetrazine,",
"pipradrol,",
"and",
"methylphenidate",
"[Hitomi",
"&",
"Schuster",
"(38)7.",
"One",
"of",
"the",
"striking",
"features",
"of",
"cocaine",
"self-administration",
"is",
"the",
"marked",
"regularity",
"of",
"inter",
"self-administration",
"intervals.",
"Pickens",
"&",
"Thompson",
"(49)",
"showed",
"that",
"the",
"regular",
"pausing",
"following",
"cocaine",
"self-administration",
"on",
"fixed-ratio",
"schedules",
"was",
"related",
"to",
"both",
"the",
"vaiue",
"of",
"the",
"schedule",
"and",
"the",
"amount",
"of",
"drug",
"infused.",
"Infusing",
"equal",
"amounts",
"of",
"drug",
"following",
"fixed-",
"tio",
"food-reinforced",
"responding",
"produces",
"comparable",
"pausing",
"to",
"that",
"during",
"drug-reinforced",
"responding.",
"It",
"would",
"be",
"desirable",
"to",
"compare",
"the",
"relations",
"between",
"magnitude",
"of",
"reinfarcement",
"and",
"overall",
"response",
"rate",
"across",
"classes",
"of",
"drugs.",
"Unfortu-"
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50277153-7153.layout.json
|
[
"For",
"Tosacco",
"ResearcE-U.S.",
"A,",
"INc.",
"&",
"‘&Ab",
"SEP",
"1g",
"1084",
"|",
"—",
"MEMORANDUM:",
"To",
"Executive",
"Committee,",
"Scientific",
"Advisory",
"Board",
"Drs.Jacobson,",
"Bing,",
"Bremnan,",
"Feldman",
"and",
"Gardner",
"?",
"':Q&",
".",
"Copies",
"to",
"Drs.Ford,",
"Hockett,",
"Lisanti,",
"McAllister,|",
"Sarmer:",
"Stone",
"RE:",
"INQUIRY",
"(CASE",
"NO.",
"1051",
")",
"NAME",
":",
"J.",
"C.",
"TAYIOR,",
"PH.D.",
"Institution",
"&",
"address:",
"City",
"of",
"Hope",
"National",
"Medical",
"Center",
"Duarte,",
"CA",
"*",
"Attached",
"are",
"copies",
"of",
"key",
"documents",
"concerning",
"this",
"inqufry.",
"Please",
"indicate",
"below",
"your",
"recommended",
"action,",
"and",
"return",
"ballot",
"1n",
"envelope",
"provided.",
"e:",
"gdw",
"DDD",
"Obtain",
"additional",
"information,",
"as",
"follows:",
"A}W_)M",
"M%",
"[fl",
"M%)M",
"Awsc&{MJ",
"%",
"1.",
"DISCOURAGE",
"formal",
"applidation.",
"2,",
"ENCOURAGE",
"formal",
"application.",
"D",
"4,",
"Defer",
"for",
"discussion",
"at",
"next",
"Executive",
"Committee",
"Meetin",
"isposirfin;",
"specify:",
"i",
"50277153"
] |
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2046807567_7643-3.layout.json
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[
"17:17",
"637",
"1503",
"PHILIP",
"MORRIS",
"C¢",
"CRS-3",
"fourth?®",
"shows",
"an",
"increased",
"risk",
"which",
"is",
"not",
"statistically",
"significant",
"at",
"the",
"95",
"percent",
"level.",
"An",
"extensive",
"review",
"of",
"the",
"litevature",
"on",
"ETS",
"and",
"lung",
"cancer",
"risk",
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"any",
"lung",
"cancer",
"risk",
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"increase",
"as",
"integrated",
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"quantity)",
"exposure",
"to",
"ETS",
"increases.",
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"four",
"recent",
"studies",
"(Fontham,",
"et.al,",
"Brownson,",
"et.al.,",
"and",
"Stockwell,",
"et.al.)",
"report",
"statistically",
"significant",
"excess",
"risk",
"values",
"at",
"the",
"highest",
"exposure",
"levels",
"(pack-years",
"in",
"two",
"cases,",
"smoker",
"years",
"in",
"another),",
"and",
"about",
"one-third",
"of",
"tha",
"studies",
"reviewed",
"by",
"EPA",
"for",
"dose",
"response",
"behavior",
"show",
"a",
"statistically",
"signifizant",
"(at",
"the",
"95",
"percent",
"level}",
"upward",
"trend.",
"{\\",
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"trend",
"results",
"do",
"not",
"appear",
"2o",
"be",
"conclusive,",
"howsver,",
"and",
"even",
"at",
"the",
"l\\",
"greatest",
"integrated",
"exposure",
"leveis,",
"the",
"measured",
"risks",
"are",
"still",
"subject",
"to",
"considerable",
"uncertainty.",
"Data",
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"the",
"Foatham,",
"et.al.,",
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"result",
"in",
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"5500",
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"lung",
"cancer",
"Geaths",
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"This",
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"Tean",
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"Data",
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"deaths",
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"model",
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"gs",
"a",
"Limiting",
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"behavior,",
"the",
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"number",
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"deaths",
"caleulated",
"from",
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"Fontham,",
"et.al,",
"data",
"is",
"440",
"and",
"530",
"for",
"the",
"Brownson",
"data.",
"Over",
"70",
"percent",
"of",
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"deaths",
"in",
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"example",
"and",
"all",
"of",
"the",
"deaths",
"in",
"the",
"threshold",
"model",
"to",
"individuals",
"who",
"are",
"exposed",
"to",
"spousal",
"ETS.",
"The",
"remaining",
"deaths",
"would",
"result",
"from",
"backgrownd",
"ETS",
"which",
"also",
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"the",
"number",
"of",
"deaths",
"in",
"the",
"spousally",
"exposed",
"group",
"in",
"the",
"no",
"threshold",
"example.",
"Using",
"the",
"results",
"obtained",
"from",
"the",
"Fontbam,",
"et.al,",
"data",
"in",
"the",
"no",
"threshold",
"example,",
"a",
"person",
"exposed",
"to",
"spousal",
"and",
"background",
"ETS",
"has",
"about",
"a",
"9/10",
"of",
"one",
"percent",
"chance",
"of",
"ying",
"of",
"lung",
"cancer",
"from",
"the",
"ETS",
"over",
"her",
"[ifetime.",
"Yor",
"a",
"person",
"exposed",
"oniy",
"to",
"background",
"ETS,",
"the",
"number",
"drops",
"to-",
"2bout7/100",
"of",
"one",
"gercenn",
"The",
"most",
"effective",
"way",
"o",
"Jower",
"the",
"chancs",
"of",
"Tutig",
"cancer",
"desth",
"TTom",
"appears",
"to",
"be",
"a",
"reduction",
"in",
"exposure",
"to",
"spousal",
"ETS.",
"SOURCES",
"OF",
"UNCERTAINTY",
"The",
"major",
"sources",
"of",
"uncertainty",
"are",
"confounders",
"factars",
"other",
"than",
"ETS",
"which",
"rould",
"explain",
"the",
"measured",
"risk",
"values,",
"and",
"misclassification",
"—",
"an",
"incarrect",
"identification",
"of",
"current",
"smokers",
"or",
"recently",
"quit",
"smokers",
"as",
"never",
"smokers.",
"Evidence",
"from",
"a",
"number",
"of",
"studies",
"examining",
"possible",
"confounders",
"appears",
"inconclusive",
"about",
"whether",
"they",
"may",
"be",
"responsible",
"for",
"the",
"risk",
"values",
"measured",
"in",
"the",
"ETS",
"studies.",
"The",
"statistical",
"upcertainties",
"exhibited",
"in",
"the",
"epi",
"studies",
"of",
"most",
"of",
"these",
"possible",
"Confounders",
"suggests",
"that",
"none",
"of",
"them",
"can",
"be",
"cBusiderad",
"4",
"clear",
"causs",
"of",
"inhibiteT",
"of",
"lung",
"cancer,",
"Furthermore,",
"there",
"is",
"mixed",
"&¥idence",
"about",
"the",
"correlation",
"of",
"these",
"confounders",
"with",
"increasing",
"integrated",
"3",
"Stockwell,",
"H.G-at.al",
"Journal",
"of",
"the",
"Nationai",
"Cancer",
"Institute,",
"Vol.84,No.18,",
"1992,",
"p.1417-",
"1422,",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"@004/035",
"0LGL089F0¢"
] |
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44007100.layout.json
|
[
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"Taxation!",
"A",
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"3",
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"With",
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"what",
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"_lnou‘h",
"n",
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"a",
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"Even",
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"words",
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":",
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"INSTITUTE",
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"800",
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"20006",
"800-424-9876",
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"by",
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"Fredrck",
"&",
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"1988,",
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] |
509790579+-0598-8.layout.json
|
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"Jor",
"the",
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"lung",
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"Experimental",
"lung",
"tumours",
"by",
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"radfation",
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"9.45",
"to",
"10.48",
"9.45",
"10",
"10.00",
"10.00",
"10",
"10.08",
"10.05",
"t0",
"10.20",
"10.20",
"tO",
"10.25",
"10.28",
"10",
"10.40",
"10.40",
"10",
"1045",
"Chairman",
".",
".",
".",
"M.",
"Kuscuxze",
"H.",
"CEMBER",
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"I.",
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"W.J.",
"CLARKE,",
"J.F.",
"PARK",
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"(U.S.A.):",
"Plutontum",
"particle",
"Induced",
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"the",
"canine",
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"H.",
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"11.28",
"12.25",
"0",
"17.40",
"12,40",
"tO",
"1248",
"11.4%",
"10",
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"12.0§",
"2",
"142",
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"Chairman",
".",
".",
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"H.",
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"A.C.",
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"P.H.",
"GUTTMAN",
"(U.S.A.)",
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"Rad-",
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"M.",
"S.",
"LASKIN,",
"M.",
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"lwng",
"in",
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"L.",
"FRIBERG",
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"B.",
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"(Sweden):",
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"«nd",
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"radloaclfve",
"monodisperse",
"test",
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"10",
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"Meeting",
"4B.",
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".",
".",
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"V.",
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"Conference",
"Lecture:",
"G.1{.",
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"(U.X.):",
"Physiology",
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2022161585_2022161648-57.layout.json
|
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502307321+-7322-0.layout.json
|
[
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"]",
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2044308148.layout.json
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501302256_501302323-61.layout.json
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[
"SUPERVISOR'S",
"INSTRUCTIONS",
"COMMUNICATION",
"TEST",
"BMR",
"#47-810",
"Page",
"3",
"Questionnaire",
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"This",
"questionnaire",
"has",
"been",
"set",
"up",
"and",
"written",
"using",
"a",
"format",
"which",
"may",
"be",
"a",
"1ittle",
"different",
"than",
"what",
"you",
"are",
"used",
"to.",
"Consequently,",
"some",
"of",
"the",
"termin-",
"ology",
"and",
"instructions",
"on",
"the",
"questionnaire",
"need",
"to",
"be",
"explained",
"further.",
"Don't",
"be",
"offended",
"if",
"these",
"instructions",
"seem",
"to",
"be",
"more",
"detailed",
"than",
"neces-",
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"just",
"that",
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"certain",
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"we",
"are",
"all",
"speaking",
"the",
"same",
"\"language\"",
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"the",
"terminology",
"used.",
"Below",
"are",
"some",
"general",
"comments",
"about",
"the",
"format",
"and",
"terminology",
"used:",
"1)",
"On",
"the",
"questionnaire,",
"the",
"sentences",
"to",
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"read",
"aloud",
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"typed",
"using",
"all",
"upper",
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"(capital)",
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"the",
"questions",
"as",
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"we",
"don't",
"want",
"the",
"respondent",
"led",
"or",
"prompted.",
"The",
"instructions",
"(to",
"the",
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"in",
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"lower",
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"2)",
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"word",
"for",
"word.",
"If",
"a",
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"is",
"speaking",
"too",
"quickly,",
"ask",
"him/her",
"to",
"slow",
"down",
"while",
"you",
"are",
"writing.",
"Interviewing",
"Format",
"Respondents",
"will",
"be",
"screened",
"on",
"the",
"mall",
"and",
"interviewed",
"at",
"the",
"interviewing",
"station.",
"The",
"question",
"format",
"is",
"as",
"follows:",
"Brand",
"Ratings/Usual",
"Brand",
"Comprehension",
"of",
"Ad",
"Attitudes",
"Coupon",
"Use/Purchase",
"Patterns",
"Intentions",
"Classification",
"The",
"Interview*",
"A.1,",
"2,",
"3",
"Read",
"these",
"questions",
"exactly",
"as",
"printed.",
"Do",
"not",
"allow",
"the",
"respon-",
"dent",
"to",
"interrupt.",
"Should",
"they",
"do",
"so,",
"continue",
"to",
"read",
"the",
"entire",
"guestion.",
":",
"A1l",
"open-end",
"answers",
"should",
"be",
"recorded",
"verbatim.",
"Practice",
"Interviewing",
"Validation",
"Forms",
"Every",
"interviewer",
"should",
"practice",
"interviewing",
"before",
"the",
"study",
"begins.",
"Have",
"each",
"interviewer",
"ask",
"another",
"interviewer",
"the",
"questionnaire.",
"They",
"should",
"then",
"switch",
"places",
"so",
"every",
"interviewer",
"is",
"given",
"the",
"opportunity",
"to",
"practice.",
"Each",
"interviewer",
"is",
"to",
"complete",
"a",
"separate",
"validation",
"form.",
"Record",
"the",
"respon-",
"dent's",
"name,",
"phone",
"number",
"and",
"interview",
"date.",
"Fi11",
"in",
"the",
"heading",
"infornation",
"on",
"the",
"form.",
"Send",
"these",
"validation",
"forms",
"in",
"a",
"separate",
"envelope",
"marked:",
"Attn:",
"Barb",
"Bobbitt,",
"along",
"with",
"the",
"completes",
"at",
"the",
"end",
"of",
"the",
"study.",
"NOTE:",
"STAPLE",
"THE",
"OPEN-END",
"ANSWER",
"SHEET",
"T0",
"THE",
"BACK",
"OF",
"THE",
"MAIN",
"QUESTIONAIRE",
"AFTER",
"COMPLETING",
"THE",
"INTERVIEW,",
"L1eZ",
"0Elog"
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60016613_60016621-4.layout.json
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"Kidney",
"Tumors.",
"Discussion",
"Break",
"Speaker",
"2:",
"Interaction",
"of",
"Estrogens",
"in",
"Microfubule",
"Assembly:",
"Significance",
"for",
"Aneuploidy.",
"Discussion",
"Speaker",
"3:",
"Mechanism",
"of",
"Estrogen",
"Carcinogenesis:",
"Cell",
"Proliferation,",
"Aneuploidy",
"and",
"Chromosomal",
"Imbalance.",
"Discussion",
"Lunch",
"P.",
"Lichter",
"(GERMANY)",
"j.S.",
"Nérris",
"(USA)",
"A.",
"Llombart-Bosch",
"(SPAIN)",
"M.",
"Metzler",
"(GERMANY)",
"S.A.",
"Li",
"(USA)"
] |
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524860047+-0116-59.layout.json
|
[
"fifl",
"Tobscco",
"Spience",
"Research",
"Conference",
"—",
"State",
"of",
"The",
"Business",
"2000",
"The",
"objectives",
"of",
"this",
"study",
"were",
"to",
"investigate",
"the",
"mechanisms",
"of",
"transfer",
"of",
"ammonia",
"in",
"smoke",
"from",
"the",
"ammonia",
"compounds",
"in",
"tobacco",
"and",
"the",
"consequences",
"of",
"this",
"transfer",
"for",
"other",
"smoke",
"constituents",
"(in",
"particular",
"nicotine).",
"A",
"survey",
"of",
"54",
"commercial",
"products",
"in",
"the",
"Buropean",
"Union",
"shows",
"a",
"slight",
"increase",
"of",
"ammonia",
"in",
"smoke",
"when",
"the",
"level",
"of",
"ammonia",
"in",
"tobacco",
"increases.",
"However,",
"this",
"increase",
"is",
"much",
"lower",
"than",
"would",
"be",
"expected",
"if",
"a",
"quantitative",
"transfer",
"of",
"ammonia",
"in",
"smoke",
"from",
"ammonia",
"in",
"tobacco",
"was",
"to",
"take",
"place.",
"In",
"order",
"to",
"investigate",
"the",
"mechanisms",
"of",
"transfer",
"of",
"ammonia",
"in",
"the",
"smoke",
"and",
"the",
"possible",
"interactions",
"between",
"ammonia",
"and",
"carbohydrates",
"derived",
"compounds,",
"en",
"experimental",
"plan",
"was",
"designed.",
"Different",
"amounts",
"of",
"DAP",
"and",
"sucrose",
"were",
"added",
"to",
"a",
"standard",
"American",
"blend",
"according",
"to",
"a",
"matrix",
"design.",
"The",
"following",
"parameters",
"in",
"the",
"smoke",
"of",
"cigarettes",
"made",
"with",
"these",
"blends",
".",
"have",
"been",
"determined",
":",
"ammonia,",
"carbonyl",
"compounds,",
"pyrazines,",
"nicotine,",
"nicotine",
"in",
"vapour",
"phase,",
"and",
"the",
"«",
"smoke",
"pH",
"»,",
"From",
"these",
"data,",
"it",
"is",
"possible",
"to",
"calculate",
"statistical",
"models",
"for",
"all",
"these",
"variables",
"as",
"a",
"function",
"of",
"the",
"DAP",
"and",
"sucrose",
"levels",
"in",
"tobacco.",
"The",
"possible",
"mechanisms",
"of",
"ammonia",
"transfer",
"in",
"smoke",
"and",
"the",
"effects",
"on",
"nicotine",
"transfer",
"will",
"be",
"discussed",
"using",
"these",
"models.",
"10:5%5",
"AM",
"'WEDNESDAY",
"69.",
"APPLICABILITY",
"OF",
"GAS-PARTICLE",
"PARTITIONING",
"THEORY",
"TO",
"CIGARETTE",
"MAINSTREAM",
"SMOKE",
"John",
"H.",
"Lauterbach,",
"Brown",
"&",
"Williamson",
"Tobacco",
"Corp.,",
"Macon,",
"GA",
"31202",
"USA",
"At",
"the",
"1966",
"TCRC,",
"Vekris",
"and",
"Hook",
"reported",
"that",
"gas-particle",
"partitioning",
"occurred",
"in",
"cigarette",
"mainstream",
"smoke",
"(MSS)",
"and",
"that",
"there",
"was",
"rapid",
"dynamic",
"equilibrium",
"between",
"the",
"two",
"phases.",
"Thirty",
"years",
"later,",
"Pankow",
"and",
"coworkers",
"reported",
"that",
"gas-particle",
"partitioning",
"experiments",
"showed",
"that",
"use",
"of",
"ammonia-",
"containing",
"tobacco",
"additives",
"would",
"increase",
"MSS",
"TPM",
"pH",
"and",
"the",
"proportion",
"of",
"nicotine",
"that",
"is",
"in",
"the",
"gas",
"phase.",
"Although",
"considerable",
"experimental",
"evidence",
"has",
"been",
"presented",
"to",
"the",
"contrary,",
"Pankow",
"recently",
"reported",
"that",
"the",
"gas-particle",
"partitioning",
"coefficient",
"(Kp)",
"for",
"nicotine",
"in",
"MSS",
"ranged",
"from",
"10-2.6",
"to",
"10-4.5",
"giving",
"calculated",
"MSS",
"TPM",
"pH",
"values",
"from",
"5.7",
"to",
"8.",
"Thesc",
"values",
"were",
"based",
"on",
"Pankow’s",
"estimation",
"of",
"10-4.94",
"for",
"the",
"Kp,fb",
"of",
"unprotonated",
"nicotine",
"in",
"MSS.",
"However,",
"if",
"data",
"from",
"recent",
"studies",
"on",
"gas-phase",
"nicotine",
"in",
"MSS",
"are",
"used,",
"Kp,fb",
"is",
"on",
"the",
"order",
"of",
"10-7,",
"and",
"estimates",
"of",
"TPM",
"pH",
"range",
"from",
"4",
"to",
"6.",
"Data",
"from",
"these",
"studies",
"along",
"with",
"data",
"on",
"major",
"MSS$",
"particulate-phase",
"components",
"have",
"been",
"used",
"with",
"Pankow's",
"equation",
"for",
"absorptive",
"partitioning",
"in",
"the",
"MSS",
"aerosol",
"to",
"estimate",
"Kp",
"values",
"for",
"nicotine",
"and",
"other",
"compounds",
"in",
"MSS.",
"Estimates",
"for",
"Kp",
"for",
"nicotine",
"ranged",
"from",
"about",
"10-4.8",
"for",
"uitralight",
"products",
"to",
"10",
"3.9",
"for",
"full",
"flavor",
"products.",
"Details",
"of",
"these",
"calculations",
"along",
"with",
"estimations",
"of",
"the",
"activity",
"coefficient",
"of",
"nicotine",
"in",
"TPM",
"will",
"be",
"presented.",
"52486",
"0106",
"58"
] |
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518203741_518203796-50.layout.json
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"that",
"the",
"effect",
"reducing",
"levels",
"of",
"nitrosamines",
"in",
"tobacco",
"can",
"be",
"definitively",
"asserted,",
"responsible",
"product",
"stewardship",
"advocatss",
"that",
"technologies",
"fo",
"reduce",
"levels",
"be",
"pursued",
"and",
"implemented",
"as",
"proven",
"effective",
"and",
"commercially",
"practicable.",
".",
"How",
"does",
"changing",
"my",
"barn",
"reduce",
"them?",
"A",
"significant",
"percentage",
"of",
"the",
"Flue-Cured",
"bulk",
"curing",
"barns",
"in",
"use",
"foday,",
"utilize",
"a",
"direct-fired",
"heat",
"source.",
"While",
"the",
"fuels",
"burned",
"(propane,",
"natural",
"gas)",
"are",
"clean",
"burning,",
"the",
"resuit",
"of",
"the",
"direct",
"fired",
"process",
"is",
"that",
"products",
"of",
"combustion",
"which",
"include",
"(NOx)",
"are",
"exhausted",
"into",
"the",
"barn",
"which",
"exposes",
"the",
"tobacco.",
"Nitric",
"Oxide",
"(NOx),",
"in",
"the",
"presence",
"of",
"alkaloids",
"provides",
"the",
"apportunily",
"to",
"form",
"nitrosamines.",
"Using",
"a",
"heat",
"exchanger",
"(which",
"exhausts",
"the",
"products",
"of",
"combustion",
"outside",
"the",
"barn)",
"as",
"a",
"heat",
"source",
"eliminates",
"exposure",
"to",
"the",
"products",
"of",
"combustion",
"source",
"of",
"NOx.",
"Thus,",
"the",
"combination",
"of",
"the",
"current",
"practice",
"of",
"Flue-Curing",
"(which",
"when",
"carried",
"out",
"properly",
"reduces",
"the",
"opportunity",
"for",
"the",
"natural",
"or",
"microbial",
"mediated",
"formation",
"of",
"nitrosamines)",
"and",
"heat",
"exchange",
"heat",
"source",
"where",
"the",
"products",
"of",
"combustion",
"(NOx)",
"are",
"eliminated",
"from",
"the",
"barn",
"produces",
"cured",
"leaf",
"with",
"significantly",
"reduced",
"levels",
"of",
"nitrosamines.",
"®",
"What",
"is",
"the",
"investment",
"in",
"my",
"barn?",
"The",
"company",
"will",
"make",
"the",
"investment",
"for",
"the",
"conversion",
"from",
"a",
"direct",
"heat",
"source",
"to",
"an",
"indirect",
"heat",
"source.",
"The",
"cost",
"incurred",
"is",
"expected",
"to",
"range",
"from",
"approximately",
"$4,650.00",
"to",
"$5,300",
"per",
"barn",
"depending",
"on",
"the",
"condition",
"of",
"the",
"barn.",
"*",
"Will",
"there",
"be",
"additional",
"curing",
"costs?",
"Advancements",
"continue",
"to",
"be",
"made",
"with",
"regard",
"to",
"heat",
"exchanger",
"technology.",
"At",
"present",
"dependent",
"upon",
"climatic",
"conditions,",
"stalk",
"position",
"and",
"the",
"general",
"condition",
"of",
"the",
"tobacce,",
"and",
"curing",
"strategies,",
"fuel",
"consumption",
"has",
"ranged",
"from",
"being",
"equal",
"to",
"a",
"direct",
"fired",
"sysfem",
"to",
"as",
"mich",
"as",
"20%",
"additional",
"fuel",
"required.",
"¢",
"Will",
"|",
"have",
"to",
"cure",
"my",
"tobacco",
"differentiy?",
"No.",
"Converting",
"from",
"a",
"direct-fired",
"system",
"to",
"a",
"heat",
"exchanger",
"or",
"indirect",
"system",
"does",
"not",
"require",
"that",
"any",
"change",
"be",
"made",
"in",
"the",
"curing",
"schedule.",
"As",
"with",
"a",
"direct",
"fired",
"heat",
"source,",
"it",
"is",
"important",
"that",
"tobaccos",
"be",
"harvested",
"at",
"the",
"appropriate",
"time",
"and",
"that",
"barns",
"be",
"loaded",
"and",
"managed",
"properly",
"to",
"avoid",
"barn",
"rot",
"and",
"the",
"formation",
"of",
"nitrosamines",
"via",
"the",
"natural",
"(microbial",
"mediated)",
"means.",
"The",
"smoke",
"fiavor",
"properties",
"of",
"the",
"tobacco",
"are",
"of",
"ulmost",
"importance",
"and",
"a",
"significant",
"change",
"in",
"curing",
"schedule",
"(advance",
"curing,",
"drying",
"in",
"a",
"fewer",
"number",
"of",
"days)",
"may",
"negatively",
"impact",
"these",
"properties.",
"£80/62¢%8"
] |
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2505531228_1235-6.layout.json
|
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"were",
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"likely",
"to",
"have",
"interesting",
"andsatisfying",
"jobs",
"thanthose",
"inlower",
"level",
"jobs.",
"Another",
"factor",
"missed",
"is",
"thatthase",
"in",
"higher",
"level",
"jobs",
"may",
"not",
"always",
"have",
"to",
"spend",
"8",
"hours",
"in",
"the",
"same",
"office",
"every",
"day.",
"Environmental",
"control",
"has",
"also",
"been",
"examined",
"by",
"varicus",
"groups",
"(Wilson",
"&",
"Hedge",
"1987,",
"Hedge",
"1987,",
"1988).",
"The",
"research",
"indicates",
"that",
"those",
"dissatisfied",
"with",
"the",
"working",
"environment",
"are",
"more",
"likely",
"to",
"report",
"symptoms.",
"Hedge",
"(1987)",
"found",
"that",
"those",
"who",
"feel",
"they",
"have",
"little",
"control",
"over",
"the",
"environment",
"report",
"more",
"symptoms,",
"thus",
"suggesting",
"thatmore",
"personal",
"control",
"over",
"the",
"workplace",
"wilt",
"alleviate",
"some",
"of",
"the",
"symptoms.",
"The",
"work",
"environment",
"has",
"also",
"been",
"assessed",
"and",
"it",
"was",
"found",
"that",
"those",
"warking",
"in",
"a",
"room",
"with",
"5",
"or",
"more",
"people",
"sharing,",
"complained",
"more",
"frequently",
"of",
"sick",
"building",
"symptoms",
"(Wilson",
"&",
"Hedge",
"1987).",
"Our",
"own",
"research",
"has",
"indicated",
"that",
"in",
"one",
"office",
"population",
"there",
"were",
"significantly",
"more",
"sore",
"throats,",
"nasal",
"congestions",
"and",
"depressions",
"reported",
"from",
"those",
"working",
"in",
"offices",
"with",
"one",
"to",
"two",
"people",
"in",
"it.",
"The",
"sacond",
"office",
"sample",
"found",
"significantly",
"more",
"lethargy",
"being",
"reported",
"by",
"those",
"in",
"the",
"open-plan",
"area.",
"This",
"implies",
"that",
"although",
"the",
"work",
"environment",
"and",
"how",
"many",
"peocple",
"share",
"your",
"office",
"space",
"are",
"factors",
"in",
"symptoms",
"reported,",
"there",
"is",
"also",
"the",
"factor",
"of",
"the",
"environmental",
"Although",
"there",
"are",
"no",
"simple",
"answaers",
"to",
"the",
"Sick",
"Building",
"problem",
"there",
"are",
"still",
"tactors",
"which",
"should",
"be",
"further",
"researched,",
"such",
"as",
"the",
"role",
"of",
"occupational",
"stress,",
"overload",
"or",
"undertoad",
"of",
"wark",
"and",
"perceptions",
"of",
"the",
"working",
"environment.",
"The",
"use",
"of",
"complete",
"buliding",
"assessments",
"should",
"aiso",
"be",
"considerad.",
"Enviranmental",
"monitoring",
"shouid",
"not",
"be",
"done",
"in",
"isolation",
"but",
"as",
"part",
"of",
"health",
"assessments",
"and",
"profiles",
"of",
"the",
"organization",
"as",
"a",
"whole.",
"®",
"REFERENCES",
"Saker.",
"D.B.",
"(1989",
"Socia:",
"ang",
"orgamisationar",
"factors",
"in",
"office",
"building-associated",
":ifness",
"Occupational",
"Medicine:",
"State",
"of",
"the",
"arnt",
"re-",
"views.",
"4.4:607-624",
"Crawiord",
"J.",
"Unpublished",
"resuits",
"(1990)",
"Fanger",
"P.Q.",
"(1987}",
"A",
"solution",
"to",
"the",
"sick",
"Building",
"mystery.",
"indoar",
"air",
"{Swedish",
"Council",
"for",
"Building",
"Research)",
"49-55",
"Fanger,",
"P.O.",
"(1988)",
"Hidden",
"olfs",
"in",
"Sick",
"Buiid-",
"ings.",
"ASHRAE",
"Journal",
"30.11:40-43",
"Hedge",
"A.",
"(1987)",
"Environmental.",
"psychologi-",
"cal",
"and",
"organisational",
"corretates",
"of",
"empioyee",
"healthin",
"offices:",
"a",
"proposed",
"madet.",
"Proceed-",
"ings",
"of",
"the",
"Human",
"Factors",
"Society",
"31st",
"An-",
"Aual",
"Meeting.",
"2:736-740.",
"Hedge",
"A.",
"(1988)",
"Job",
"stress,",
"job",
"satistaction",
"and",
"work",
"related",
"iliness",
"in",
"offices.",
"Proceed-",
"ings",
"of",
"the",
"Human",
"Factors",
"Society,",
"2:777-779",
"Hedge",
"A.",
"(1990)",
"Questionnare",
"design",
"guide-",
"lines",
"for",
"investiganons",
"of",
"sick",
"buildings.",
"Pro-",
"ceedings",
"of",
"indoor",
"Air",
"1990",
"Conlerence",
"5:605-610",
"Skov",
"P.,",
"Valbjorn",
"O..",
"Pedersen",
"B.V.",
"(1989)",
"Influence",
"of",
"personal",
"characteristics.",
"job",
"re-",
"lated",
"factors",
"and",
"psychosocial",
"factors",
"on",
"the",
"sick",
"building",
"syndroms.",
"Scandinavian",
"Jour-",
"nalof",
"Work",
"Environmental",
"Health.",
"15:286-295",
"Starfing",
"T.D.,",
"Sterling",
"E..",
"Dimich-Ward",
"H.D.",
"(1983)",
"Air",
"quality",
"in",
"public",
"buiidings",
"with",
"heaith",
"related",
"complaints.",
"ASHRAE",
"Transactions,",
"89.24;198-212",
"Wilson",
"S..",
"Hedge",
"A.",
"(1387)",
"A",
"study",
"of",
"building",
"sicknass.",
"Building",
"Use",
"Studies",
"Lid.",
"London.",
"Worth",
"noting",
"The",
"Pan",
"American",
"Health",
"QOrganization",
"(PAHO)",
"has",
"adopted",
"a",
"resolution",
"on",
"workers'",
"health.",
"Noting",
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"“risk",
"factors",
"in",
"the",
"workplace",
"are",
"related",
"to",
"high",
"ratios",
"of",
"morbidity,",
"absenteeism",
"and",
"mortality",
"caused",
"by",
"diseases",
"and",
"other",
"work-related",
"ilnesses,”",
"the",
"resolution",
"sets",
"out",
"a",
"number",
"of",
"requests",
"of",
"member",
"governments",
"and",
"the",
"Director",
"of",
"PAHO.",
"It",
"also",
"designated",
"1982",
"as",
"the",
"year",
"of",
"workers'",
"heaith",
"in",
"the",
"region",
"of",
"the",
"Americas,",
"and",
"it",
"agreed",
"to",
"propose",
"to",
"the",
"World",
"Health",
"Organization",
"to",
"makeit",
"an",
"international",
"year.",
"®",
"occupational",
"accidents",
"and",
"|",
"At",
"the",
"Centre,",
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500603267+-3283-3.layout.json
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531376115+-6129-12.layout.json
|
[
"RIR1",
"News",
"Report",
"May",
"6,",
"1997",
"RJRO00000",
"70052",
"1962",
"0026006822",
"Others",
"said",
"that",
"the",
"specter",
"of",
"federal",
"regulation",
"and",
"business",
"concerns,",
"not",
"a",
"single",
"lawsuit,",
"were",
"driving",
"the",
"negotiations.",
"The",
"industry",
"“‘cannot",
"continue",
"to",
"be",
"in",
"business",
"with",
"a",
"mass",
"of",
"litigation",
"and",
"regulation",
"hanging",
"over",
"its",
"head,”",
"said",
"Cincinnati",
"trial",
"lawyer",
"Stanley",
"Chesley.",
"“They",
"need",
"to",
"get",
"it",
"all",
"settled.",
"One",
"case",
".",
".",
".",
"does",
"not",
"make",
"a",
"difference.”",
"Meanwhile,",
"some",
"new",
"players",
"were",
"added",
"to",
"the",
"talks,",
"including",
"Lonnie",
"Bristow,",
"a",
"past",
"president",
"of",
"the",
"American",
"Medical",
"Association,",
"who",
"was",
"sitting",
"in",
"as",
"a",
"voice",
"for",
"the",
"public",
"health",
"community.",
"As",
"AMA",
"head,",
"Bristow",
"took",
"a",
"strong",
"stand",
"against",
"tobacco.",
"Many",
"observers",
"remained",
"pessimistic",
"about",
"the",
"talks.",
"Stanton",
"Glantz",
"of",
"the",
"University",
"of",
"California",
"at",
"San",
"Francisco",
"crashed",
"a",
"meeting",
"last",
"Friday",
"in",
"Chicago",
"of",
"public",
"health",
"advocates",
"wrestling",
"to",
"determine",
"whether",
"they",
"could",
"support",
"the",
"negotiations.",
"Noting",
"that",
"anti-tobacco",
"Rep.",
"Henry",
"A.",
"Waxman",
"(D-Calif.)",
"also",
"had",
"not",
"been",
"invited",
"to",
"the",
"meeting",
"but",
"had",
"shown",
"up",
"anyway,",
"Glantz",
"said,",
"“There’s",
"something",
"wrong",
"when",
"Henry",
"Waxman",
"has",
"to",
"crash",
"a",
"meeting",
"on",
"tobacco.”",
"Glantz",
"said",
"he",
"believes",
"that",
"vitimately",
"the",
"taiks",
"would",
"fail—because",
"even",
"an",
"effective",
"agreement",
"would",
"be",
"killed",
"or",
"turned",
"to",
"industry’s",
"favor",
"in",
"the",
"Republican-controlled",
"Congress.",
"“You’re",
"going",
"to",
"get",
"it",
"through",
"Congress",
"in",
"one",
"piece?”",
"he",
"asked",
"rhetorically.",
"“Right.",
"You",
"and",
"Ira",
"Magaziner,”",
"he",
"said,",
"referring",
"to",
"the",
"former",
"Clinton",
"health",
"care",
"official",
"whose",
"proposals",
"were",
"killed",
"in",
"Congress.",
"“T",
"came",
"out",
"of",
"there",
"feeling",
"that",
"I",
"was",
"watching",
"a",
"tragedy",
"unfold,”",
"Glantz",
"said.",
"Source:",
"The",
"Washington",
"Post;",
"May",
"6",
"1997",
"By",
"Saundra",
"Torry",
"and",
"John",
"Schwartz",
"TOBACCO",
"TALKS",
"RESUME",
"AFTER",
"TOBACCO",
"VERDICT",
"DALLAS,",
"May",
"5",
"(Reuter)",
"State",
"attorneys",
"general",
"resumed",
"settlement",
"talks",
"with",
"cigarette",
"makers",
"Monday",
"afternoon",
"with",
"the",
"aim",
"of",
"tackling",
"the",
"difficult",
"issue",
"of",
"whether",
"there",
"can",
"be",
"a",
"cap",
"on",
"the",
"industry’s",
"liability",
"without",
"cutting",
"off",
"lawsuits.",
"Following",
"an",
"afternoon",
"meeting",
"with",
"tobacco",
"company",
"ekecutivcs,",
"Mississippi",
"Attorney",
"General",
"Mike",
"Moore",
"told",
"reporters",
"he",
"was",
"optimistic",
"about",
"the",
"progress",
"being",
"made.",
"“The",
"industry",
"continues",
"to",
"concede",
"issues",
"...",
"there",
"is",
"no",
"talk",
"of",
"immunity”",
"from",
"lawsuits,",
"Moore",
"said.",
"The",
"top",
"state",
"law",
"officers",
"broke",
"into",
"small",
"groups",
"to",
"discuss",
"the",
"afternoon’s",
"developments",
"and",
"were",
"to",
"resume",
"negotiations",
"with",
"tobacco",
"officials",
"Tuesday",
"morning.",
"The",
"negotiations",
"began",
"shortly",
"after",
"a",
"Jacksonville,",
"Fla.,",
"jury",
"awarded",
"a",
"verdict",
"in",
"favor",
"of",
"R.J.",
"Reynolds",
"Tobacco",
"in",
"a",
"case",
"brought",
"by",
"the",
"family",
"of",
"a",
"smoker",
"who",
"died",
"of",
"lung",
"cancer.",
"Attorneys",
"general",
"said",
"the",
"verdict",
"would",
"have",
"no",
"effect",
"on",
"the",
"negotiations.",
"“This",
"was",
"an",
"individual",
"case.",
"All",
"the",
"attorneys",
"general",
"that",
"are",
"here",
"today",
"in",
"Dallas",
"in",
"order",
"to",
"talk",
"to",
"the",
"industry,",
"we",
"are",
"talking",
"about",
"our",
"state",
"cases,”",
"Florida",
"Attorney",
"General",
"Robert",
"Butterworth",
"told",
"reporters.",
"13",
"{219",
"/g1eg"
] |
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0060349118.layout.json
|
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509790579+-0598-10.layout.json
|
[
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"products",
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"10",
"everyday",
"HrJO",
"No",
"190",
"of",
"18",
"August",
"1994",
"12000",
"No.287",
"of",
"10",
"December",
"1991,",
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"22",
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"1992",
"13110",
"No.201",
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"410",
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"these",
"are",
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"as",
"harmful",
"ta",
"health.",
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"milk.",
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"which",
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"to",
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"ta",
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"Denmark",
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"including",
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"no",
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"be",
"able",
"to",
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"this",
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"are",
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"of",
"preducing",
"white",
"cheeses",
"extraction)",
"which",
"do",
"not",
"necessitate",
"the",
"usc",
"of",
"bleaches,",
"although",
"switching",
"to",
"these",
"methods",
"would",
"take",
"a",
"substantial",
"investment",
"in",
"new",
"machinery",
"and",
"specialised",
"equipment.",
"As",
"they",
"stand,",
"the",
"above",
"Dircctives",
"constituie",
"an",
"indirect",
"reminder",
"of",
"the",
"feta",
"case",
"but",
"not",
"a",
"direct",
"safeguard",
"of",
"the",
"name",
"feta,",
"Greeee's",
"specific",
"request",
"to",
"recognise",
"the",
"name",
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"as",
"ageographically",
"proiected",
"indication",
"of",
"origin",
"{Regulations",
"2081/92",
"and",
"2082/92),",
"which",
"was",
"submitted",
"for",
"consideration",
"last",
"January,",
"is",
"still",
"pending.",
"Twemty",
"four",
"traditional",
"cheeses",
"have",
"been",
"included",
"in",
"the",
"list",
"of",
"those",
"demanding",
"a",
"protected",
"name",
"under",
"the",
"above",
"1w",
"Regulations",
"(1)OJ",
"No",
"L",
"208",
"23.7.92",
"ps",
"1",
"and",
"9",
"£C",
"Food",
"Lavw:",
"September",
"1994",
"©",
"1994",
"Agra",
"Europe",
"(London)",
"Lid",
"1",
"o",
"S",
"o",
"~",
"0",
"S",
"Ul",
"00",
"Ny"
] |
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503260275_503260278-2.layout.json
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[
"CHEMICAL",
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"TOXICITY",
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"M.",
"E.",
"Sippél;",
"Unpublished",
"data,",
"E.",
"I.",
"du",
"Pont",
"de",
"Nemours",
"and",
"Company,",
"Inc.,",
"Haskell",
"Laboratory,",
"Wilmington,",
"Del.",
"(November",
"1977);",
"cited",
"by",
"Patty's",
"Industrial",
"Hygiene",
"and",
"Toxicology,",
"3rd",
"ed.,",
"pg.",
"4318",
"(1982).",
"Carcinogenicity:",
"‘Subcutaneous",
"implantation",
"of",
"polyvinyl",
"alcohol",
"sponges",
"in",
"rats",
"produced",
"local",
"sarcomas;",
"negative",
"resultq",
"were",
"obtained",
"with",
"polyvinyl",
"alcohol",
"powder.",
"TARC",
"Monograph",
"on",
"the",
"Evaluation",
"of",
"the",
"Céfcihogenic",
"Risk",
"of",
"Chemiéais",
"Ed”Humans;",
"Vbi",
".19,",
"pg.",
"358",
"(1979).",
"_",
"o",
"o",
"A",
"patient",
"with",
"hemangiopericytoma",
"of",
"the",
"bladder",
"following",
"intensive",
"exposure",
"to",
"polyvinyl",
"alcohol",
"was",
"reported.",
"The",
"authors",
"\"speculated\"",
"that",
"this",
"case",
"might",
"be",
"analogous",
"to",
"vinyl",
"chloride-induced",
"hemangiosarcoma",
"of",
"the",
"liver.",
"M.",
"Prout",
"&",
"H.",
"Davis,",
"Cancer",
"39",
"1328-1330",
"(1977):",
"Pyrolysis:",
"A",
"L",
"The",
"thermal",
"degradation",
"of",
"polyvinyl",
"alcohol",
"at",
"loW",
"temperatures",
"(250°C)",
"results",
"in",
"the",
"evolution",
"of",
"water",
"and",
"the",
"formation",
"of",
"pplyacetylene;",
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"second",
"stage",
"heating",
"at",
"900°C",
"results",
"in",
"carbonization",
"with",
"the“evolupiqn‘of‘Hg,HCO,",
"CHy,",
"CpHe,",
"CpHy,",
"and",
"CO2.",
"o",
"N",
"\"",
"T",
"H",
"N",
"o",
"iln\"?‘m",
"J.",
"B",
"Gilbert",
"&",
"J.",
"J.",
"Kipling]",
"Fuel",
"12",
"219-260",
"(1962).",
"'",
"S.",
"L.",
"Madorsky,",
"Thermal",
"Degradation",
"of",
"Organic",
"Polymers,",
"Interscience",
"Pub.,",
"pgs.",
"173-175",
"“Cioehy.",
"T",
"‘",
")",
":",
"_",
"The",
"main",
"products",
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"aleohol",
"at",
"240°C",
"were",
"Hs0",
"and",
"CoHsOH.",
"\"",
"Also",
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"ketones,",
"CH3—&",
"CH=",
"CH—J3CO-CHz,",
"where",
"n",
"=",
"0;‘1;",
"2,",
"ete.",
"1",
"N.",
"Grassie",
"&",
"A.",
"Scotney,",
"\"Products",
"of",
"Thermal",
"Degradation",
"of",
"Polymers,\"",
"in",
"J.",
"Brandrup",
"&",
"E.",
"H.",
"Imergut,",
"eds.,",
"in",
"Polymer",
"Handbook,",
"2nd",
"ed.,",
"Wiley,",
"N.Y.,",
"pgs.",
"II-U473",
"to",
"II-U79",
".",
"v",
"W",
"2L",
"~",
"The",
"\"smoldéring‘combustiofi“»Qf",
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"reportédlyvféféégéd*lérgé‘QQanfities",
"”",
"of",
"acrolein",
"and",
"formaldehyde.",
"'",
"‘",
"‘",
"T",
"T.",
"Morikaua,",
"Jour",
"Conbust.",
"Toxicol.",
"3",
"135-150",
"(1976).",
"\"",
"LLTO",
"-9CEDS",
"S",
"pomnmi",
"e",
"o",
"e",
"a",
"¥"
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0060143407-5.layout.json
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508939370_508939517-128.layout.json
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2163
],
[
1495,
2132,
1560,
2163
],
[
1768,
2133,
1860,
2164
],
[
2023,
2133,
2113,
2164
],
[
2269,
2133,
2365,
2164
],
[
456,
2232,
500,
2261
],
[
989,
2232,
1107,
2262
],
[
1265,
2233,
1358,
2262
],
[
1494,
2234,
1559,
2263
],
[
1767,
2234,
1859,
2264
],
[
2023,
2234,
2112,
2263
],
[
2271,
2235,
2364,
2265
],
[
455,
2330,
499,
2360
],
[
989,
2332,
1106,
2361
],
[
1264,
2333,
1357,
2362
],
[
1494,
2334,
1558,
2363
],
[
1767,
2333,
1860,
2363
],
[
2019,
2334,
2112,
2363
],
[
2267,
2334,
2364,
2363
],
[
454,
2432,
498,
2462
],
[
1011,
2432,
1105,
2463
],
[
1264,
2434,
1355,
2463
],
[
1493,
2434,
1558,
2463
],
[
1767,
2433,
1858,
2464
],
[
2021,
2457,
2029,
2463
],
[
2044,
2433,
2111,
2463
],
[
2267,
2434,
2364,
2463
],
[
453,
2531,
497,
2560
],
[
1010,
2533,
1105,
2561
],
[
1263,
2533,
1356,
2562
],
[
1493,
2534,
1558,
2562
],
[
1765,
2533,
1859,
2563
],
[
2021,
2534,
2109,
2564
],
[
2267,
2534,
2363,
2563
],
[
2355,
2749,
2385,
2767
],
[
2355,
2775,
2385,
2799
],
[
2355,
2808,
2384,
2828
],
[
2354,
2837,
2384,
2856
],
[
2354,
2866,
2384,
2887
],
[
2353,
2928,
2382,
2948
],
[
2352,
2958,
2382,
2978
],
[
2352,
2990,
2382,
3008
],
[
2351,
3019,
2381,
3038
]
] |
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