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BRIEF RESEARCH REPORT article
Sec. Virus and Host
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
Human cytomegalovirus (HCMV) is an important pathogen in immunocompromised individuals and neonates, and a paradigm for viral immune evasion. We previously developed a quantitative proteomic approach that identified 133 proteins degraded during the early phase of HCMV infection, including known and novel antiviral factors. The majority were rescued from degradation by MG132, which is known to inhibit lysosomal cathepsins in addition to the proteasome. Global definition of the precise mechanisms of host protein degradation is important both to improve our understanding of viral biology, and to inform novel antiviral therapeutic strategies. We therefore developed and optimized a multiplexed comparative proteomic analysis using the selective proteasome inhibitor bortezomib in addition to MG132, to provide a global mechanistic view of protein degradation. Of proteins rescued from degradation by MG132, 34–47 proteins were also rescued by bortezomib, suggesting both that the predominant mechanism of protein degradation employed by HCMV is via the proteasome, and that alternative pathways for degradation are nevertheless important. Our approach and data will enable improved mechanistic understanding of HCMV and other viruses, and provide a shortlist of candidate restriction factors for further analysis.
Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that persistently infects the majority of the human population worldwide (Cannon et al., 2010). Following primary infection under the control of a healthy immune system, a latent infection is established that persists lifelong (Reeves et al., 2005). Although primary infection is mostly asymptomatic in healthy individuals, HCMV may lead to significant morbidity or mortality in immunocompromised patients, particularly transplant recipients and AIDS patients (Griffiths et al., 2015). Vertical transmission of HCMV is a leading cause of congenital infection, resulting in deafness and intellectual disability in newborns (Manicklal et al., 2013). Existing therapies that either target the viral polymerase or terminase are associated with significant toxicity and/or sporadic resistance (El Helou and Razonable, 2019). The identification and characterization of critical facets of host innate immunity that are targeted for degradation by HCMV proteins thus has important implications for antiviral therapy, since such interactions may be inhibitable by small-molecules, facilitating endogenous inhibition of viral replication (Nathans et al., 2008).
HCMV has been reported to disrupt interferon (IFN) production (Kim et al., 2017; Goodwin et al., 2018), neutralize the IFN response (Le-Trilling and Trilling, 2015; Le-Trilling et al., 2020), inhibit natural killer (NK) cell activation (Patel et al., 2018), and avoid T cell surveillance via downregulation of MHC molecules (Jackson et al., 2011). Additionally, diverse effects on other key cellular functions have been observed including on cell cycle regulatory proteins and ubiquitin ligases themselves (Weekes et al., 2014; Clark and Spector, 2015; Koshizuka et al., 2016; Koshizuka et al., 2018). A common final pathway for many host protein targets is proteasomal or lysosomal degradation (Halenius et al., 2015; Le-Trilling and Trilling, 2020). HCMV facilitates viral replication by degrading components of cellular promyelocytic leukemia nuclear bodies (PML-NB) Sp100, MORC3, and DAXX that act as restriction factors (Kim et al., 2011; Tavalai et al., 2011; Schreiner and Wodrich, 2013; Sloan et al., 2016). We previously developed three orthogonal proteomic/transcriptomic screens to quantify protein degradation early during HCMV infection, identifying 133 degraded proteins that were enriched in antiviral restriction factors. The power of this approach was demonstrated by our identification of helicase-like transcription factor (HLTF) as a novel restriction factor that potently inhibited early viral gene expression and was targeted by the HCMV protein UL145 (Nightingale et al., 2018). However, a global approach to identify the mechanism of HCMV-induced protein degradation is lacking. Our previous study employed the broad, non-selective inhibitor MG132, which is known to affect lysosomal cathepsins in addition to the proteasome (Wiertz et al., 1996), and leupeptin which is a naturally occurring protease inhibitor that can inhibit some proteasomal proteases in addition to the lysosome (Nightingale et al., 2018).
In this study, we used the selective proteasome inhibitor bortezomib (Chen et al., 2011) to identify proteins specifically targeted for proteasomal degradation during HCMV infection. This identified that the majority of proteins rescued from degradation by MG132 were also rescued by bortezomib, highlighting the role of viral subversion of the proteasome in immune evasion. Our data additionally provide a shortlist of proteins degraded by the proteasome early during infection that are enriched in known antiviral factors for further investigation.
Material and Methods
Cells and Cell Culture
Primary human foetal foreskin fibroblast cells (HFFFs) immortalized with human telomerase (HFFF-TERTs, kindly provided by Dr. Richard Stanton at School of Medicine, Cardiff University) (McSharry et al., 2001) were maintained in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% v/v foetal bovine serum (FBS), 100 U/ml penicillin, and 100 μg/ml streptomycin at 37°C with 5% CO2 (DMEM/FBS/PS). HFFF-TERTs have been tested at regular intervals since isolation to confirm that human leukocyte antigen (HLA) and MHC Class I Polypeptide-Related Sequence A (MICA) genotypes, cell morphology, and antibiotic resistance are unchanged.
Virus and Virus Titration
The recombinant HCMV (RCMV1111) used was derived by transfection of a BAC clone of HCMV strain Merlin, the genome of which is designated the reference HCMV sequence by the National Centre for Biotechnology Information and was sequenced after three passages in vitro (Dolan et al., 2004; Stanton et al., 2010). Virus stocks were prepared from HFFF-TERTs as described previously (Nobre et al., 2019). Tissue culture supernatants were kept when a 100% cytopathic effect was observed, and were centrifuged to remove cell debris. Cell-free virus was pelleted from supernatant by centrifugation at 15,000×g for 2 h and then resuspended in fresh DMEM. Residual debris was removed from the resulting virus stocks by centrifugation at 10,000xg for 1 min. Virus titration was achieved by intracellularly staining HCMV IE1/2 in HFFF-TERTs that had been infected with serially diluted HCMV. Cells were harvested 24 h post-infection, fixed in 4% paraformaldehyde, permeabilized with ice-cold methanol, blocked with human TruStain FcX Fc receptor blocking solution (Biolegend) and then subjected to primary (anti-HCMV IE1/2, mouse monoclonal 6F8.2, Millipore) and secondary (anti-mouse IgG conjugated with Alexa Fluor 488, Thermo) antibody incubation. Data was acquired by FACSCalibur (BD biosciences) and analyzed with FlowJo software (BD biosciences). The percentage of infected cells was determined by the percentage of IE1/2 positive cells, which was used to calculate the titre of virus stock.
Virus Infections and Inhibitors
1x106 HFFF-TERTs were plated in a 25 cm2 flask. After 24 h, the medium was changed to DMEM lacking FBS but with 4 μg/ml dexamethasone, as this approach has been shown to improve infection efficiency (Tanaka et al., 1984). After 24 h, the medium was changed to DMEM containing the requisite volume of HCMV strain Merlin stock to achieve MOI 5. Cells were gently rocked (5 rpm) for 2 h, and then the medium was changed to DMEM/FBS/PS. MG132 (Sigma) at 10 μM or bortezomib (Sigma) at a range of concentrations was added to the cell culture 12 h prior to sample collection. Bortezomib was used at final concentrations between 50 nM–2 µM. Inhibitors were dissolved in dissolved in dimethyl sulfoxide (DMSO, Sigma), which was used at the same final concentration in both treated and untreated samples. For 12 hpi experiments, inhibitors were added to the initial viral mixture used for infection, which was replaced with drug-containing fresh DMEM after the 2 h of incubation.
Quantitative Tandem-Mass-Tag Based Proteomics Analysis and Statistical Analysis
Methods of proteomics analysis were described in our previous publication (Nightingale et al., 2018), and are briefly described here with a detailed description in the supplementary information. Whole cell lysates were digested into peptides with LysC and trypsin, and equal amounts of peptide labelled with 10-plex tandem-mass-tag (TMT) reagents. (Thermo, Cat # 90110). Enriched, labelled peptides were subjected to liquid chromatography coupled with multi-stage mass spectrometry (LC-MS3) prior to quantification of ~2,500 proteins in a single mass spectrometry analysis using an Orbitrap Fusion Lumos (Thermo). To acquire more comprehensive data, TMT-labelled peptide samples were subjected to high pH reversed-phase fractionation (HpRP) to generate 12 combined peptide fractions prior to mass spectrometry. Mass spectra were processed using a SEQUEST-based software pipeline for quantitative proteomics, “MassPike”, through a collaborative arrangement with Professor Steven Gygi’s laboratory at Harvard Medical School. Experiments were performed in one biological replicate. The method of significance A was used to estimate the p-value that each ratio was significantly different to 1 using Perseus version 184.108.40.206 (Cox and Mann, 2008). Values were adjusted for multiple hypothesis testing using the method of Benjamini-Hochberg (Cox and Mann, 2008).
Cells were lysed with RIPA buffer (Cell Signaling) containing Complete Protease Inhibitor Cocktail (Roche) and then lysates were sonicated with Bioruptor Pico (Diagenode). Protein concentration was measured by BCA kit (Thermo). Lysates were reduced with 6X Protein Loading Dye (Tris 375 mM pH 6.8, 12% SDS, 30% glycerol, 0.6 M DTT, 0.06% bromophenol blue) for 5 min at 95°C. Thirty μg of protein for each sample was separated by PAGE using 4–15% TGX Precast Protein Gels (Bio-rad), then transferred to PVDF membranes using Trans-Blot Systems (Bio-rad). The following primary antibodies were used: anti-GLG1 (MAB78791, R&D Systems) and anti-GAPDH (MAB374, Millipore). Secondary antibodies were IRDye 680RD goat anti-mouse (925-68070, LI-COR) and IRDye 800CW goat anti-rabbit (925-32211, LI-COR). Fluorescent signals were detected and quantified using a LI-COR Odyssey scanner and Image Studio software (LI-COR).
Optimization of Bortezomib Concentration for Experiments in HFFF-TERTs
Bortezomib has been employed in a number of studies of human cell lines as a specific inhibitor of the proteasome. However, a wide range of concentrations have been used, from 0.1 to 20 µM (Price et al., 2011; Chui et al., 2019). To optimize conditions for proteomic analysis in HCMV-infected immortalized primary human foetal foreskin fibroblasts (HFFF-TERTs), a range of bortezomib concentrations were compared with 10 μM MG132, a concentration we previously showed to provide efficacious inhibition of protein degradation (Figures 1, S1A–B) (Nightingale et al., 2018). TMT peptide labels and MS3 mass spectrometry enabled very precise protein quantitation, as well as multiplexed analysis of up to 16 samples in the same experiment.
Figure 1 Optimization of bortezomib concentration by comparison with 10 µM MG132. (A) Schematic of the experimental workflow. HFFF-TERT cells were infected with Merlin strain HCMV (MOI 5) or mock infected and simultaneously treated with 10 µM MG132, 500 nM, 1 µM, or 2 µM bortezomib. Samples were harvested at 12 hpi to maximize the ability to study very early infection as we previously described (Nightingale et al., 2018). Whole cell lysates were digested into peptides, which were labelled with TMT reagents followed by MS3 mass spectrometry. (B) Comparison of 10 µM MG132 with 500 nM, 1 µM, or 2 µM bortezomib during HCMV infection. Each dot represents a protein quantified in the experiment. The x-axis shows the fold change of protein abundance +/- 10 µM MG132 during HCMV infection. The y-axis shows the fold change of protein abundance +/- 500 nM, 1 µM, or 2 µM bortezomib during HCMV infection. The equations and correlation coefficients of the linear trend lines are shown.
For each protein, ratios of (HCMV with bortezomib)/HCMV and (HCMV with MG132)/HCMV were compared to quantify the relative efficacy of protein rescue. Here, we define “rescue” as the increased expression of a given protein in the presence of inhibitor in the context of viral infection. In order to make an appropriate comparison of fold rescue by both drugs, it was necessary to ensure that a difference could confidently be quantified upon addition of either drug. At lower bortezomib concentrations, rescue ratios were close to 1 with a compressed range of values, making it difficult to assess significance of any given change (Figure S1B). The trend of linear correlation and slope of the trend line both increased with increasing bortezomib concentration, with a gradient near to one for 2 µM bortezomib. At this concentration, the degree of rescue was most similar between MG132 and bortezomib, enabling the same fold-change cut off to be applied for both MG132 and bortezomib analyses and 2 µM bortezomib at 12 h post infection (hpi) was therefore selected for detailed assessment (Figures 1A, B). A comparison of mock infection in the presence of either inhibitor at optimized concentration identified very similar protein changes (Figure S1C), suggesting that although there may be off-target effects of either inhibitor, at a protein level at least these are similar. Furthermore, comparison of protein changes in the presence of MG132 at 12 h of HCMV infection from this and our previous study showed positive correlation, albeit in some cases with different effect sizes on an individual protein level (Figure S2, Table S4).
Multiple Host Proteins Are Targeted for Proteasomal Degradation Early During HCMV Infection
To build a comprehensive picture of host protein degradation during the first 12 h of HCMV infection, data from experimental samples described in Figure 1A (that included the 2 µM bortezomib condition) was analyzed in detail. Overall, 7,192 host proteins were quantified, 145 of which were down-regulated by HCMV >1.5-fold (with p < 0.01) compared to mock infection. MG132 and bortezomib “rescue ratios” were calculated for each protein, obtained by comparing protein abundance during HCMV infection +/- inhibitor with protein abundance during mock infection +/- inhibitor (Figure 2A).
Figure 2 Identification of proteins targeted for degradation by HCMV using an inhibitor-based proteomic screen. (A) Results of the inhibitor-based screen. All 145 proteins downregulated >1.5 fold are plotted, with down-regulated proteins divided into 4 groups using rescue ratios of >1.5 as cut-offs. The table shows the number of proteins in each group. For rescue ratios, the denominator (mock with drug)/mock was limited to a minimum of 1 to prevent artificial ratio inflation. (B) Examples of positive controls from the existing literature that were validated in this screen. (C) Examples of degraded proteins rescued >1.5-fold by both inhibitors (top panels), MG132 but not bortezomib (middle panels), and bortezomib but not MG132 (bottom panels).
For simplicity and consistency with our previous study (Nightingale et al., 2018), a rescue ratio of >1.5-fold with p<0.01 was set as a threshold to identify proteins rescued by either MG132, bortezomib or both (Figures 2A, Table S1). Using these criteria, 64/145 (44%) proteins were considered to be rescued by either inhibitor, with 34/64 proteins rescued by both drugs. Notably, this group contained the known HCMV restriction factors Sp100, MORC3, DAXX, and HLTF in addition to cell cycle regulating protein ANAPC1, all of which have been reported to be degraded during HCMV infection by ourselves and others (Figure 2B) (Tran et al., 2010a; Chen et al., 2011; Kim et al., 2011; Tavalai et al., 2011; Schreiner and Wodrich, 2013; Sloan et al., 2016; Nightingale et al., 2018).
Data from all proteomic experiments in this study are shown in Table S2. Here, the worksheet “Plotter” is interactive, enabling generation of graphs of protein expression of any of the proteins quantified.
Certain proteins exhibited a greater degree of rescue with MG132 compared to bortezomib (Figure 2B, yellow dots). Of the 21 proteins only rescued >1.5 fold by MG132, 13 (62%) exhibited bortezomib rescue ratios of >1.25 and <1.5, suggesting that many of this group of proteins may nevertheless be proteasomally degraded. These included the PDZ domain containing protein 11 (PDZD11) and transcriptional repressor BEN Domain Containing 3 (BEND3) (Figure S3, Tables S1–2). In contrast, 8/21 proteins appeared genuinely to be selectively rescued by MG132 but not bortezomib (bortezomib rescue ratio <1.25), including the fibroblast growth factor receptor Golgi Glycoprotein 1 (GLG1), E3 ligase NEDD4, and carbohydrate sulfotransferase 14 (CHST14) (Figure 2C middle panel, Table S1). Similar data were obtained for treatments with 500 nM and 1 µM bortezomib, validating these findings, and differential effects of MG132 and bortezomib on GLG1 protein were validated by immunoblot (Figures 3A, B). Interestingly, Gene Ontology annotation of all 8 proteins indicated an association with either the cell membrane, the Golgi apparatus, or vesicle secretion. Furthermore, comparison of data with our previous study examining protein rescue by MG132 or leupeptin indicated that GLG1, NEDD4, and CHST14 were also significantly rescued by treatment with the lysosomal protease inhibitor leupeptin (Figure 3A), suggesting that a proportion of the proteins rescued by MG132 alone are degraded lysosomally.
Figure 3 Proteins rescued by MG132 but not bortezomib are also rescued by Leupeptin. (A) Results for GLG1, NEDD4 and CHST14, proteins selectively rescued by MG132 but not bortezomib. The left hand panels show data from the complete MG132/bortezomib screen and the right hand panels show the MG132 (10 µM)/Leupeptin (200 µM) screen (12 hpi) described previously (Nightingale et al., 2018). (B) (Left panel) Immunoblot showing differential effects of proteasome inhibitors MG132 (MG) and bortezomib (bort) on GLG1 protein during HCMV infection (MOI 5, 12 hpi). (Right panel) Quantitation of GLG1 relative to GAPDH (internal loading control).
Of proteins exhibiting a greater degree of rescue with bortezomib compared to MG132 (Figure 2A, purple dots), 8/9 (89%) exhibited MG132 rescue ratios >1.25 but <1.5 (examples in Figure S2, 2C bottom panel), suggesting that the majority of all proteins in this class were in fact rescued by both inhibitors. The one exception was LIM domain-containing protein AJUBA, whose MG132 rescue ratio was 1.16 in this data (Figure 2C bottom panel), but neared significance in our previous study (Table S2); these differences may reflect relatively poor quantitation by only two or one peptides respectively.
Proteasomal Regulation of Viral Proteins
The application of MG132 during infection led to significant changes in the abundance of several viral proteins. Overall, 82 viral proteins were quantified, including 77 canonical proteins and 5 novel open reading frames (ORF). Two, ORF1872 and US34, were up-regulated by both MG132 and bortezomib (Figure 4, Table S5), suggesting they were readily degraded via the proteasome during early infection. We previously identified ORF1872 as a putative unstructured and inherently unstable protein (Nightingale et al., 2018). Only glycoprotein gH (UL75) was up-regulated by MG132 in the absence of substantial upregulation by bortezomib (Figure 4, Table S5). gH was quantified in our previous multiplexed MG132/leupeptin analysis (Nightingale et al., 2018). Its rescue by MG132 and leupeptin but not bortezomib is likely to reflect lysosomal proteolysis after virion entry through endocytosis.
Figure 4 Regulation of 82 viral proteins by proteasome inhibitors. Viral proteins up- or down-regulated >2-fold by both proteasome inhibitors are marked in purple, with proteins up- or down-regulated >2-fold by one proteasome inhibitor, but <2-fold by the other inhibitor marked in green.
HCMV is known to be a master regulator of host immunity, achieving lifelong persistence in infected individuals by utilizing a wide range of strategies to modulate host protein expression. These include the deployment of proteins to target host factors for degradation. Here, we provide a searchable database that systematically details the route of degradation of cellular proteins during the establishment of a productive HCMV infection. Furthermore, this data can be used to predict molecules of key importance in antiviral immunity to HCMV on the basis of their degradation.
MG132 is a less selective proteasomal inhibitor than bortezomib, having previously been reported to inhibit lysosomal degradation pathways via inhibition of calpains and cathespsins (Kisselev and Goldberg, 2001), in addition to the proteasome. In our previous publication, 75% of proteins rescued by leupeptin at 12 h of infection were also rescued by MG132. The usefulness of comparing this broad proteasomal/lysosomal inhibitor with the specific proteasomal inhibitor bortezomib is the identification that 62–85% (34–47 proteins) of proteins rescued by MG132 were also rescued by bortezomib, suggesting that the proteasome is the predominant route for early protein degradation at 12 h post-HCMV infection. Overall, of all downregulated proteins, 44% were rescued by at least one of MG132 or bortezomib. It is possible that in order to downregulate certain proteins, HCMV must employ degradative pathways in order to achieve sufficiently rapid change in protein abundance.
We and others have previously shown that membrane proteins are targeted for lysosomal degradation during HCMV infection (Weekes et al., 2013; Fielding et al., 2014; Hsu et al., 2015; Fielding et al., 2017), and data here identified that all proteins rescued by MG132 but not bortezomib had a membrane origin. Certain proteins were exclusively degraded by a non-proteasomal route, including GLG1 and CHST14. Extension of these inhibitor studies to examining membrane-enriched samples, for example samples enriched for plasma membrane proteins (Weekes et al., 2013; Weekes et al., 2014) would therefore be of substantial interest, and may identify a distinct degradative route for proteins originating from these compartments.
Comparison of data from this study with our previous transcriptional analysis of host gene expression during infection at 24 hpi (Nightingale et al., 2018) suggested that 44 of the 81 proteins (54%) with MG132 and bortezomib rescue ratios <1.5 were more than 1.5-fold transcriptionally downregulated, which would be expected to be a major mechanism of protein downregulation in the absence of degradation (Tirosh et al., 2015). The fold change cut off of 1.5 for both downregulation by HCMV, and rescue by either inhibitor was based on a significance threshold of p <0.01, however had the effect of excluding proteins with “borderline” rescue ratios of >1.25 but <1.5. 39/81 proteins with MG132 and bortezomib rescue ratios <1.5 exhibited rescue ratios for MG132 or bortezomib or both that were nevertheless >1.25, suggesting that this group of proteins included some candidates that downregulated by degradation, at least in part.
Proteasome activity is necessary for efficient viral gene transcription and viral replication (Prösch et al., 2003; Kaspari et al., 2008; Tran et al., 2010b; Le-Trilling et al., 2016). More viral proteins were down- than up-regulated upon application of proteasome inhibitors at 12 hpi, including seven down-regulated >2-fold by both MG132 and bortezomib. One reason could be that cellular factors hindering viral gene transcription (e.g. ND10 components) are no longer degraded during HCMV infection in the presence of proteasome inhibition, leading to impaired expression of viral genes. This highlights that there are at least two mechanisms that could lead to the stabilization of a given host protein. The first is degradation of the host protein along the pathway inhibited by the drug. A second possibility is reduction by the drug of the abundance of a viral protein responsible for the degradation process. For instance, US22, which was down-regulated by MG132 and bortezomib, has been reported to function as an RNA-associated viral protein, thus has the potential to regulate gene expression post transcriptionally (Lenarcic et al., 2015). Although none of the viral proteins downregulated >2-fold by both MG132 and bortezomib or MG132 alone are known to target host proteins for degradation, their downregulation could potentially provide an alternative explanation for some of the changes we observed.
Overall, this analysis of host protein degradation during HCMV infection has not only identified proteasomal degradation as a key mechanism subverted by the virus early during infection, but has also generated a shortlist of proteasomally degraded proteins enriched in known HCMV restriction factors. Further investigation into the role of the other proteins in this shortlist is warranted to determine if they also have restrictive capabilities. Identification of HCMV restriction factors, understanding the mechanism by which they restrict infection and identification of viral antagonists that target these factors for degradation are of fundamental interest due to the potential for therapeutic intervention.
Data Availability Statement
The datasets generated for this study can be found in the ProteomeXchange Consortium via the PRIDE partner repository (Perez-Riverol et al., 2019), dataset identifier PXD021961.
K-ML, KN, and MW designed the experiments. K-ML, KN, and MW wrote the manuscript. K-ML, KN, and RA performed the experiments. K-ML, KN, LS, and MW analyzed the proteomics data. K-ML, KN, LS, and MW edited the manuscript. MW supervised all research. All authors contributed to the article and approved the submitted version.
This work was supported by a Wellcome Trust Senior Clinical Research Fellowship (108070/Z/15/Z) to MW and a strategic award to Cambridge Institute for Medical Research from the Wellcome Trust (100140).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We are grateful to Prof. Steven Gygi for providing access to the “MassPike” software pipeline for quantitative proteomics.
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2020.578259/full#supplementary-material
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Stanton R. J., Baluchova K., Dargan D. J., Cunningham C., Sheehy O., Seirafian S., et al. (2010). Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication. J. Clin. Invest. 120, 3191–3208. doi: 10.1172/JCI42955
Tanaka J., Ogura T., Kamiya S., Sato H., Yoshie T., Ogura H., et al. (1984). Enhanced replication of human cytomegalovirus in human fibroblasts treated with dexamethasone. J. Gen. Virol. 65 ( Pt 10), 1759–1767. doi: 10.1099/0022-1317-65-10-1759
Tavalai N., Adler M., Scherer M., Riedl Y., Stamminger T. (2011). Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle. J. Virol. 85, 9447–9458. doi: 10.1128/JVI.00870-11
Tirosh O., Cohen Y., Shitrit A., Shani O., Le-Trilling V. T., Trilling M., et al. (2015). The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions. PloS Pathog. 11, e1005288. doi: 10.1371/journal.ppat.1005288
Tran K., Kamil J. P., Coen D. M., Spector D. H. (2010a). Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J. Virol. 84, 10832–10843. doi: 10.1128/JVI.01260-10
Tran K., Mahr J. A., Spector D. H. (2010b). Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription. J. Virol. 84, 3079–3093. doi: 10.1128/JVI.02236-09
Weekes M. P., Tan S. Y., Poole E., Talbot S., Antrobus R., Smith D. L., et al. (2013). Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection. Science 340, 199–202. doi: 10.1126/science.1235047
Weekes M. P., Tomasec P., Huttlin E. L., Fielding C. A., Nusinow D., Stanton R. J., et al. (2014). Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction. Cell 157, 1460–1472. doi: 10.1016/j.cell.2014.04.028
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Keywords: human cytomegalovirus, HCMV, quantitative proteomics, protein degradation, proteasome inhibitors, tandem mass tag (TMT), proteasome, lysosome
Citation: Lin K-M, Nightingale K, Soday L, Antrobus R and Weekes MP (2021) Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics. Front. Cell. Infect. Microbiol. 10:578259. doi: 10.3389/fcimb.2020.578259
Received: 30 June 2020; Accepted: 08 December 2020;
Published: 27 January 2021.
Edited by:Michael Nevels, University of St Andrews, United Kingdom
Reviewed by:Mirko Trilling, University of Duisburg-Essen, Germany
Scott Terhune, Medical College of Wisconsin, United States
Copyright © 2021 Lin, Nightingale, Soday, Antrobus and Weekes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Michael P. Weekes, firstname.lastname@example.org
†These authors have contributed equally to this work | <urn:uuid:b24eef7e-01ba-4ca6-b714-6c7820f68182> | CC-MAIN-2022-33 | https://www.frontiersin.org/articles/10.3389/fcimb.2020.578259/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Cellular_and_Infection_Microbiology&id=578259 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.894115 | 9,615 | 1.890625 | 2 |
Month: June 2011
The World in Motion
By Thomas Christensen
Forthcoming January 2012
from Counterpoint Press
The world of 1616 was a world of motion. Enormous galleons carrying silk and silver across the Pacific created the first true global economy, and the first megacorporations were emerging as economic powers rivaling political states. In Europe In Europe the deaths of Shakespeare and Cervantes marked the end of an era in literature. The spirit of the Renaissance was giving way to new attitudes that would lead to the age of revolutions. Kepler and Galileo, following Copernicus, claimed that the earth itself revolved. In Persia the philosopher Mulla Sadra said that motion was the very essence of existence. In East Asia the last native Chinese dynasty was entering its final years, while Japan was beginning its long period of shogunal rule. Artists there, as in many part of the world, were rethinking their connections to ancient traditions and experimenting with new directions. Women were redefining their roles in family and society. Slave trading was relocating large numbers of people, while others were migrating in search of new opportunities — a Japanese samurai became governor of a province in Thailand, an Ethiopian slave became the prime minister of a principality in India, a Powhatan maiden from Virginia attended a royal court masque in London. The first tourists, traveling not for trade or exploration but for personal fulfillment, were exploring this new globalized world: an Englishman walked across India, an Italian explored Muslim West Asia, a Chinese scholar spent decades compiling a massive account of journeys through China.
In 1616: The World in Motion Thomas Christensen illuminates these changes by focusing on a single riotous year, telling surprising stories of the men and women who were forging a new world and drawing unexpected connections across countries and continents as he traces the developments that would set the world on the march to modernity.
THOMAS CHRISTENSEN’s previous books include New World/New Words: Translating Latin American Literature, The U.S.–Mexican War, and The Discovery of America, as well as translations of books by such authors as Laura Esquivel, Carlos Fuentes, Julio Cortázar, Alejo Carpentier, and Louis-Ferdinand Céline. He is director of publications at the Asian Art Museum in San Francico.
The above is very early promotional copy for my new book, tentatively scheduled for publication in January 2012.
At this time I need to update the cover image, which is still showing an older version of the subtitle. I love the cover painting, which combines Western, Hindu, Muslim, and other elements. Art critics call this style of painting, commissioned by the Mughal emperor Jahangir, “allegorical painting” — this painting suggests Jahangir’s (imagined) world domination. The painting, by Abul Hasan, depicts Jahangir shooting an arrow through the mouth of the decapitated head of Malik Ambar (a rebel leader; this part of the painting is hidden behind the book title cartouche). The painting dates, naturally, from 1616.
I suspect the subtitle may change.
I’ll make this a sticky post at the top of the 1616 category page and update it as the prepublication process moves along. I’ll just update the time stamp to keep this at the top of the category page.
Help! For the book I’m working on I’m trying to identify the painters of these frescos in the Quirinale (the Italian equivalent of the White House). They depict foreign ambassadors to the Vatican, and I’d also like to identify the ambassadors — but first things first.
I’ve consulted several books in both English and Italian but remain uncertain about the attributions. My best guess at this point is that the top two are mainly by Carlo Saraceni, the third one by Agostino Tassi, and the last one perhaps by Giovanni Lanfranco.
Among the ambassadors are Robert Sherley, Aliqoli Beg (not entirely sure who that is), Emanuele Ne Vunda, Hasekura Tsunenaga, and Luis Sotelo (the last a Franciscan missionary and not an ambassador per se). Can the Turkish and Persian ambassadors be distinguished by their styles of turbans?
Even if you don’t know the answers to these questions, if anyone can point me in the direction of an obliging Italian painting specialist I could be in touch with about this it would be a great help. Thanks!
This image is by the great Mughal painter Abul Hasan (I devote a few pages to him in the book I’m currently working on). Usually called “Squirrels in…
When you attempt something ambitious you’re bound to make some mistakes along the way. I’m sure the book I’m working on will have its fair share (recently I… | <urn:uuid:8ee64f4c-66ef-426d-bc5c-7f61a91fbd1e> | CC-MAIN-2022-33 | https://www.rightreading.com/blog/2011/06/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.954223 | 1,044 | 2.3125 | 2 |
The Waroona Agricultural Society Inc. was founded in 1925 to coordinate an annual event known as “the Waroona Show”. This event brings the community together in a celebration of Arts, Culture, Competitions and Agriculture. In 2022, The Waroona Agricultural Society will celebrate its 91st Show.
The Society consists of an executive and general committee who are volunteers representing a wide cross section of the community and who work tirelessly all year to ensure the shows success. On show day the list of volunteers grows to over 60, not including those working for other community organisations.
The Waroona Show is the largest single event in the Shire, and is the single biggest fundraising event in the year for local community organisations. The Waroona Show is also the only Agricultural show in the Peel Region.
The show boasts many attractions each year including wood chopping, side show alley, trade stalls, horse, cattle and poultry competitions, free activities for the kids, photography, cooking, sewing, horticulture, floral, arts and creative arts competitions, music, entertainment and the grand finale spectacular the “Alcoa fireworks display”.
History of the Waroona Show
The Waroona Agricultural Society Incorporated was founded in 1925 to coordinate an annual event known as “the Waroona Show”. The Waroona Show is a cultural and sporting event that brings the community together.
Originally known as the Drakesbrook Agricultural Society, the name changed in 1929 to Waroona – Hamel and Districts Agricultural Society a name they retained until the early 1950’s. In that time, the Society has only had a small number of years where the show was unable to be run. These include the World War 2 years from 1940 to 1945 and again in 2020 due to the Covid Pandemic. On reading old newspaper items, it would appear that a smaller event was run in 1940 known as the Patriotic Show.
The objects of the Society are to establish, maintain and conduct an Agricultural Show for the purpose of providing exhibitions of agricultural, pastoral, mineral and industrial products and livestock including horses in action and to promote, encourage and assist the development of educational, art, cultural and historical activities.
The Society changed their name to “Waroona Agricultural Society Inc.” in 1951 and became an incorporated body on the 23rd July 1976.
In 2022, the Waroona Agricultural Society will celebrate its 91st show. | <urn:uuid:4dbe2174-0372-4486-be72-70ff0383d720> | CC-MAIN-2022-33 | https://www.waroonashow.com.au/about-us/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.954177 | 507 | 1.796875 | 2 |
Is deflate a Scrabble word?
Yes, deflate is a Scrabble word!
...and is worth 11 points in Scrabble, and 12 points in Words with Friends
Deflate is a valid Scrabble word.
Table of Contents
6 definitions of the word deflate.
- Collapse by releasing contained air or gas
- Release contained air or gas from
- Reduce or lessen the size or importance of
- Produce deflation in
- Reduce or cut back the amount or availability of, creating a decline in value or prices
- Become deflated or flaccid, as by losing air
What Scrabble words can I make with the letters in deflate?
Words that can be created with an extra letter added to deflate:
There are 4 words that can be made by adding another letter to 'deflate'. | <urn:uuid:9d6922dd-6bcf-4d05-80a9-5cb6940c8b38> | CC-MAIN-2022-33 | https://wordfind.com/word/deflate/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.903384 | 186 | 2.625 | 3 |
Medicare is funded in several ways. Medicare Part B covers hospital and in-patient care and 89 % is covered by pay tax. Medicare Part B covers inpatient medical care and gets funding through the General Revenue. Typically general revenues are funds collected through government taxes or from other non-taxable sources for government programs.
Medicare Part D is an optional benefit that covers medical expenses but also receives 73% of the money sourced from the general economy. Part C – also known as Medicare Advantage — is funded through Medicare Part A and Part B, and the monthly premium paid by the enrollee's insurance company.
Unlike most Medicare programs, Supplementary Plans are covered entirely by premiums paid by beneficiaries as well as coinsurance. Plans received no federal funding. Because Medicare Part A & Part BP covers 80% of health expenses, supplemental plans are a method of removing coverage gaps and decreasing the amount the insured pays.
Applicants may be offered Supplementary Plans, known as Medigap policies, by insurers such as ACA, AIG and Unitedhealthcare.
Medicare is a health plan that provides health protection for millions of Americans over 60 and a number of people who suffer from ill health or disabilities. However, although Medicare plans advertise themselves as free Medicare expenditures can be as high as $300 billion annually. How many Americans use Medicare? Medicare funds its operations via multiple taxpayer funded trust funds. This paper focuses on how Medicare can be funded through multiple sources, including a variety of sources.
Medicare funds were secured by two trust funds, which are limited to a single purpose. Hospitals Insurance Trust funds are funded by payroll taxes paid by employees, employers and the self-employed. This money is intended for paying Medicare Part A benefits. The supplemental Medicare trust fund can help with premium payments from Medicare, and some avenues such as making investments from the trust fund. These funds cover Medicare benefits and programs administration expenses.
Medicare is supported by an aggregation of taxes paid into trust accounts deposited with beneficiary premiums and by the Congress' supplementary fund authorizations. Medicare spending in 2019 reached $896.8 billion. This article looks into Medicare's funding mechanisms. Similarly there was discussion about changing Medicare costs. Some of the terms discussed here may make a good guide for deciding on an insurance plan.
Hospital insurance trust fund Taxes paid by employers, employees, and self-employed people provide money for the HI trust fund, which was founded in 1965. The trust fund also garners the interest earned on its investments, income taxes from some Social Security benefits, and income from Medicare Part A premiums.
It is funded by two trust funds which provide for services under Part B of Medicare Part A. Currently the Hospital Insurance Trust funds provide the funds necessary to cover Part A services. Other trust funds known as Supplemental Insurance Trust Fonds (SI) are used for Part B and Part D. Part A is funded through the HS Trust Fund.
Part A and Part D are financed by the SMI Trust. The HI Trust Fund is funded through these resources to finance Part A. The SMI Trust Fund is funded using funds provided by Part B and Part D.
Nearly 75% of the annual Medicare Part B spending comes out of government income that is generally funded from federal taxes. Another 25% comes through monthly premiums owed by Medicare participants. Social Security interest is just about 11% of Part B funds.
Part B enrolment payments can vary annually. In 2021, the standard monthly payment for Medicare Part A was $710.20, which automatically gets taken off Social Security. In addition, enrollment for people earning less than $99000 annually pays higher rates.
Medicare reimburses insurer companies who administer Medicare Advantage plans a fixed fee per beneficiary. These funding comes from Medicare Part B accounts for Medicare Part A and B services provided by the policies. It is normally over $1000 a month that the companies receive from beneficiaries in the Advantage plans. Medicare spends about $48 billion annually for Medicare Part c. It offers plans for additional coverage for prescription drugs.
A staggering 73% of Medicare D expenditures relate exclusively to general revenues and taxes. A further 15% is provided by beneficiary premiums and a further 11% of the money is provided to Medicaid eligible, double-eligible recipients who qualify for both Medicare and Medicaid benefits. Medicare Part D is a free option for beneficiaries who have received original Medicare coverage for prescription drugs.
Part D prescription drug coverage from private insurers covers prescription drug premiums. Those who qualify pay premiums,deductibles and copays.
Taxpayers who have earned taxable income are obligated to pay Medicare taxes on any salary. Once Medicare tax rates had been capped for income, but that limit was withdrawn in 1993. Now all earnings are tax deductible at 29%. Employers who receive wages on W-2 pay 50%, 14% and employees pay another 50%. Generally, the employer remits the employee's debt so that the owed debt does not accrue during the period. Self-employed tax payers pay for it but have the option to deduct half for their business expenses.
In addition there's additional tax on the income earned by people who have AGIs below the above criteria. This is called Medicare contributions taxes or net investment income taxes. The tax owes a third tax rate to the tax payers for taxable income from taxable assets paid to individuals and employees in retirement accounts as opposed to employer-sponsored retirement accounts. This includes income derived from taxable activities as well as income from the business day traders.10.
The total number of Medicare enrollees in Jerry is responsible if the $250,000 he earns is repaid by $25,000 or more. A second amount equaling $20,000 will be due in the future for a total of $25,000. The total is $275. Finally, the businessman has to pay 3% from his total investment profits, bringing his total income up by $2660. His total Medicare payment will be $9410 ($625 + $225 +1 666).
It's possible that Jerry is a single person that inherits a lot of the property whose well-head produces oil and gas revenues. A salesman for a technology firm earned $225k for the year, up from 1099. The oil and gas company's annual royalty is $500,000. The entrepreneur earned about $20,000 in cash from selling his stock.
Medicare is managed by Medicare / Medicaid Services, a division of the Health and Human Services Department. CMS works closely with DOL and Treasury in creating insurance reforms. The SSA determines eligibility level for benefits. Medicaid on its part is governed by state laws. While all states are involved with the program it is not required. ACA expanded coverage by providing more health insurance to millions of people and making it easier for them to get a job.
The Medicare Advantage program (Part C) is not separately financed. Medicare Advantage plans, such as HMOs and PPOs, cover Part A, Part B, and (typically) Part D benefits. Funds for Part A benefits provided by Medicare Advantage plans are drawn from the Medicare HI trust fund (comprising an estimated 42% of HI trust fund expenses in 2021). Funds for Parts B and D benefits are drawn from the Supplementary Medical Insurance (SMI) trust fund.
Part D plans and Medigap plans also charge a monthly premium. Deductibles. A deductible is the amount of money that you pay before Medicare will cover your services. Part A has a deductible per benefits period, whereas Part B has a deductible per year. Some Part D plans and Medicare Advantage plans with drug coverage also have a drug deductible. Copayments. Copayments are up-front fees that you pay each time you visit a doctor or specialist.
The SMI trust funds are financed annually by the federal government in an attempt to reduce potential budget deficits. The HI Trust Fund receives no annual budget compared with the SMI Trust Fund and makes the fund vulnerable to economic conditions such as the resulting decrease in payroll taxes while the health and insurance costs remain rising. Medicare Part A revenues outpace those in Medicare Part A.
This results in a slowly and surely depleted fund. The government forecast the HI Trust Fund to run out of money by 2026 by 2020.
Medicare is the only form for the protection of millions of Americans. They represent the largest social insurance coverage in the country, and serve over 100 million people, including disabled and disadvantaged young adults. All employees should pay for these programs either by calculating payroll deductions or by filing taxes.
President Joseph Biden urged states and territories to extend their Medicaid services in an attempt to help seniors with incomes under 138%. In May 2021 14 States were in an income range well below those limits in the states. During the program federal aid was available to states extending Medicaid to adults with eligible low income people.
Medicare and Medicaid offer two separate services that serve two disparate populations and also receive different funding levels. Medicare is funded through government grants. Medicaid is a federally and stately program providing medical care for people who do very little in their daily life. This is funded through federal as well as state funding.
Medicare is financed via several sources: 46 percent of federal revenues are from income taxes, 34% come from Medicare payroll taxes, and 15 percent come from premium payees. Other funds include social security taxation and earned interest.
Medicare is a federal program which largely provides Medicare funds to the federal government. In fact, the federal government contributes to Medicare and Medicaid enrollment by allowing them to enroll. Medicare gets money from two trust funds : the hospital insurance (HI) trust fund and the supplementary medical insurance (SMI) trust fund.
The trust funds get money from payroll taxes, as allowed by the Federal Insurance Contributions Act (FICA) enacted in 1935. Also, Medicare taxes at a tax rate of 2.9% are taken from people who are self-employed. Other trust funding money includes premiums and income from investments.
Beneficiaries with annual incomes over $85,000 per individual or $170,000 per couple pay a higher, income-related Part B premium reflecting a larger share of total Part B spending, ranging from 35% to 85%. Part D, which covers outpatient prescription drugs , is financed primarily by general revenues (71%) and beneficiary premiums (17%), with an additional 12% of revenues coming from state payments for beneficiaries dually eligible for Medicare and Medicaid.
Costs associated with Part C may include a monthly premium, copays, and deductibles. Part D costs Medicare Part D offers coverage for prescription drugs.
Medicare pays for medical care costs, hospital and physician visits, prescription drug costs, and other medical care. Medicare spending is often a key factor in the federal health budget debates as it represents 11% of national health costs and 13% of the federal budgets. | <urn:uuid:5e51258b-6f6d-4fd7-96a3-32e132d67934> | CC-MAIN-2022-33 | https://centurymedicare.com/how-medicare-is-funded/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.966744 | 2,206 | 2.5 | 2 |
By Zach Schofield
Fast rising prices and increasing in-affordability continue to characterize the housing market along the Wasatch Front. The root cause of this problem is that the stock of new houses being built isn’t able to keep pace with Utah’s fast growing population. Supply is not able to keep up with demand. With too few homes desired by so many prospective buyers, sellers start at higher asking prices, those with more means offer higher bids, and the price of a home quickly climbs above what the average family can afford. As we contemplate reforms that bring the supply of homes that our community needs, it may be helpful to draw from the experience of other cities in the United States. Here we present the tale of three cities: Houston, Denver and Los Angeles; three cities that have taken different approaches to zoning ordinances and have had very different outcomes.
As far as housing goes, Houston is a pretty sweet spot to be. According to Zillow data, the average price of a home in December 2020 was just $202,538 – half the average price of the Salt Lake City metro area ($428,280) in a city with at least double the population of Salt Lake County. The good news doesn’t stop at the low price. According to HUD data on homelessness, the total homeless population in Hoston dropped by 53.5% from 2011 to 2019 and now stands at 3,938 in a city of 2.3 million. The average price of housing has grown by about 80% since the first month of 2011 – a clipper rate, but much lower than the Salt Lake Area (101%) and the other cities we’ll highlight here.
Denver isn’t the worst place you could go to try to find a house, but things are going the wrong direction. The average home price stood at $492,013 in December 2020. This is more than double the price of Houston. The rate at which that figure is increasing however is pretty nuts – 109% increase since January of 2011. One bright spot to report is that the homeless population dropped by 19.7% from 2011 to 2019 – totalling 5755 humans in a city of 727,211 – still a larger population in a smaller city when compared to Houston.
Los Angeles however is a different story. The average price in December 2020: $802,702. Percent Increase from January 2011: 89.8%. The homeless situation is something approaching tragedy. The number of homeless people in Los Angeles has shot up by 62.5% from 2011 to 2019; totalling now 56,257 souls in a city of 10 million.
What could account for this stark difference in housing markets? One city, Houston, has housing prices half that of Salt Lake City and Denver, and nearly a fourth that of Los Angeles. Prices are also increasing there at a much slower rate than many other large cities in the west. One likely reason is that Houston doesn’t have, and never had, a zoning code. Other than some use restrictions, deed restrictions and building codes, housing supply has been able to match demand for decades – contributing to the affordability of the area, slow growth in prices, and successes in homelessness.
Cities like Los Angeles on the other hand, have for decades been making long lists of rules that restrict how many homes builders can provide. According to one review, single family zoning laws now restricts 75% of residential land in Los Angeles to either single family houses or duplexes.
There are certainly factors like geography and economic size which also impact the price of housing. But the facts are clear – when city councils force restrictions on what can and can’t be built in our neighborhoods, we all suffer – the homeless, the poor, young families, and immigrants especially so.
The good news is that the solution is at our feet. If restrictions on housing are relaxed or removed, fewer Utahns will live in fear of losing the roof over their head. That’s the Utah I want to live in. | <urn:uuid:01bac711-17d1-4afe-8bc9-11c926bb5e67> | CC-MAIN-2022-33 | https://prosperityutah.org/the-tale-of-three-cities/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.966153 | 825 | 1.875 | 2 |
( – promoted by buhdydharma )
Cross posted at KOS
Social Justice. Some of us were introduced to the idea in church, appropriately because Jesus preached social justice. Altho social justice is an important theme in all major religions, some churches like the Catholic Church have offices of Social Justice. In deed the term was coined by a Jesuit priest in the mid 1800’s, based on the teachings of Thomas Aquinas.
It got a lot of press both good and bad in the 60’s when Jesuit priests preached social justice and organized the impoverished of South America. Social Justice is the heart of Liberation Theology and Black Liberation Theology. Follow me below the fold for a little background on social justice, why shooting the messenger is counterproductive and oh yes, the grand experiment of YES WE CAN.
Social justice, the idea the best society is one where individuals and groups enjoy the fair treatment and the benefits of the society equally. Of course, we sometimes know that this isn’t always the case, which is why there are lawyers are there who can help make sure that people get fair treatment (you can read this article here for more information). Interestingly, depending on your political bent, your idea of a just society or equal society may differ. The philosophy of social justice is apolitical, politicizing it makes it something less. It becomes a means to serve some, not all as it is meant to be. We’ve seen a lot of politicized justice thru the years.
The Bill of Rights addresses quite eloquently the concepts of social justice important to our founding fathers. Life, liberty and the pursuit of happiness covered on the DOI, the protection of minority rights. Clearly the framers wanted to create a just society open to all, regardless of how imperfectly it has been applied.
Social justice requires a government in making policies, to keep the needs of the poor and vulnerable at the forefront. It’s interesting how this can play out in reality because it doesn’t mean a huge welfare state. Social justice requires all human beings be treated with dignity and with equal opportunity to have all our society offers. Welfare devalues human beings and moves them even further from the benefits we enjoy.
Things like equal pay, minimum wage, affirmative action, women’s suffrage, choice, civil rights, gay rights, marriage equality, free school lunches, SCHIPS, free education K-12, affordable higher education, workers rights and labor unions, United Nations, sentencing reform, anti-death penalty, work place safety, voter’s rights, immigration reforms, VISTA, Peace Corp, environmental protection, green economy, Food Stamps, child care deduction, Head Start, Pell Grants, Community Colleges, FDIC, universal health care, FMLA, the New Deal, Social Security and Government backed home loans. This list is by no means complete and while some have been politicized, they all have at their heart Social Justice. These programs and ideals make a society livable for more and more citizens until eventually all individuals and groups enjoy equally the benefits of economic security, political rights, social rights and opportunities. This represents the America most of us would want.
We saw social justice in the programs of FDR and JFK. They were the messengers of change and social justice we found acceptable. Churches thru the years have been the most consistent groups pushing for social justice. Those messengers we do not like so much. We don’t like their words or their tone, but they work for all of us as surely as they work for the poor and vulnerable in their communities.
By now you should know about all the good work of Rev. Wright’s Church TUCC, what you may not know about is the work of the other messengers you have been encouraged to hate and discount.
Michael Pfleger Jesuit trained Pfleger became the youngest full pastor in the diocese when he was appointed Pastor of Saint Sabina Church. During his time there the church as evolved to a full fledged African American church and he has worked to make Saint Sabina a vibrant and important part of the community.
The church and Reverend have been pivotal in helping transform Auburn Gresham, with new housing and store fronts opening up in the neighborhood. As of 2007, one the largest new single-family home developments in Chicago is nearing completion at W. 87th St. and S. Parnell Ave., in the southeast corner of Auburn Gresham. Auburn-Gresham is also home to the first urban S.O.S. Children’s Village in the U.S.
Please visit their website, they like Trinity use their resources to help the most vulnerable, the elderly, children, homeless, jobless, drug addicts, gang bangers, and prostitutes.
From their website.
Father Pfleger received a special honor, when at the request of Mrs. Coretta Scott King, he was selected to be the keynote speaker for the national Dr. Martin Luther King, Jr. Commemorative Service. This event was held on January 20, 2003, at Ebenezer Baptist Church in Atlanta, Georgia
He is not a light weight or crank, however over the top his speech at Trinity happened to be. Remember he was talking to proudly pro Obama crowd. Remember to, Trinity and St Sabina deal with racism every day trying to help the results of our prejudices take their rightful place in America. He is a much sought after, well respected voice in healing the racial divide and social justice for the disadvantaged.
On June 3 Michael Pfleger was removed from his parish St. Sabina, this will be a terrible blow to the community he served.
CBS 2 New has learned that Francis Cardinal George is temporarily removing Father Michael Pfleger from his position as pastor of St. Sabina Roman Catholic Church on Chicago’s South Side.
Among his friends is Louis Farrakhan, another messenger we have been encouraged to not only hate, but disregard, marginalize.
What few of us know about Farrakhan is his tireless work toward unity. His programs of self help address the disadvantaged of all races. The unity of the people who believe in one God, that would be Christians, Muslims and Jews. Seems odd when all you have heard about is he represents separatism and how he hates Jews. He blasts anyone who doesn’t live up to the ideals of their faith. He blasts this country too. There an article written by Farrakhan concerning the plight of the poor.
During the run up to the war in Iraq he traveled with a delegation of religious leaders and physicians to the Middle East. An effort to start a dialog among leaders of those nations, his hope was they could prevent the war. He along with other religious leaders tried to meet with Bush to explain what folly the war would be. Bush wasn’t interested. He has for years preached and encouraged black men to take responsibility for their families and communities, to work with other groups in similar positions like Hispanics and Native Americans and to help and support each other.
NOI programs of self reliance and self respect have reclaimed drug addicts, excons, prostitutes and gang bangers, helped them turn their lives around and become responsible citizens in their communities. NOI owns and operates Muhammad Farms. The farm has allowed them create food co-ops for the poor and the sale of crops to provide money to build housing among other things. This investment goes back into the poorest communities. They have created jobs and job training. They support and encourage small minority businesses and have done much to give economic opportunities in the most depressed neighborhoods. Many people confuse NOI with Muslims world wide. NOI is a uniquely American faith adhering to a very few aspects of traditional Islam.
It is true Farrakhan is controversial, it is true he is anti-gay, it is true he has no time for any religious group who twists their beliefs to do harm in the world or purveyors of drugs and pornography. To get a better look at him read the interview with Donahue. He certainly isn’t a saint but he isn’t the devil either. Discounting the good he does because you hate some of his positions is counter productive particularly when we use our hatred of HIM to discount the good work of other churches because they dared to acknowledge Farrakhan’s very real contributions. These churches, these men work on the fringes of society, they work every day to lift up those we have forgotten. No matter how much we dislike their rhetoric, or how uncomfortable their words make us, we owe them a debt of thanks. They are doing the work this country should have done generations ago.
I know, you find them insulting and blaming, maybe even a little racist themselves. You’ve never heard anything like that. Sorry, but a lot of you have. How quickly MLK has been sanitized and we forget his speeches about ending poverty and this country’s war mongering. Nope, probably wouldn’t have liked him much either. Social justice requires speaking truth to power and it is often ugly, hurtful and even polarizing. They are talking to and about people who have been significantly disadvantaged not for a few generations, which is itself unconscionable, but for centuries. Indulge me a little history and perhaps some perspective.
The first black men arrived in the Virginia Colony in 1619. A Dutch had taken about 20 black men from a Spanish ship they robbed. They then traded the men to the colony for food. By 1640 at least one of them was listed in the census as a slave. Declared and ordered by the court. They came to this country 389 years ago and 21 years later slavery against the black man had started. Over the next 223 years between 9 and 12 million Africans were bought to America as Slaves.
The Emancipation Proclamation parts one and two didn’t really free blacks. Older voices condemned the proclamation because it never addressed the real need for racial reforms. For them it was about more than being free, it was about being truly equal. The ratification of the 13th amendment which abolished slavery forever, but didn’t address equality. It would take the 15th Amendment to make voting a reality for all blacks. It was ratified in 1870, 8 years after they were given personhood, released from slavery and allowed to vote in the first place.They could vote and be counted as a whole person. Unfortunately, in the South Jim Crow was born and separate but equal became the norm. Stumbling blocks were put in place to make voting virtually impossible. They would remain de facto slaves and even the Civil Rights Act of 1964 didn’t fix the voting problem.
1964 is 44 years ago, well within the memory of large percentage of African Americans. They waited 323 years to be equal enough to participate in our society. Can you imagine the deep well of anger, pain and frustration 323 years creates? 323 years of having little or no say in their lives, 323 years of inferior education and inferior economic opportunities. 323 years of violence against their people, violence that continues. What changes have happened have happened slowly and racism is still alive and well in this country. Blacks are still fighting for equality, they fight for it today as hard as they fought 100 years ago.
For this to work, to move forward and reconciliation to have a chance, we must own our part. We must listen with compassion understanding, not judging or devaluing experiences. Trying to ignore 323 years like it didn’t happen because things are better will accomplish nothing and they earned the right to be heard.
I haven’t touched on Native Americans whose struggle is as long. After more than 200 years of genocide against them are now bring neglected to extinction. I cannot tell their story as eloquently as Winter Rabbit. Please read these diaries, they are the true experiences of the native people not taught in our history books.
Earned the right to be heard. This is true of all oppressed groups if we are to move toward reconciliation, we must not kill the messenger. Ignoring those voices, vilifying them and marginalizing them further only serves to make reconciliation harder and longer to accomplish. Reconciliation is about forgiveness on both sides, we have to forgive each other and ourselves. And we have much to do.
And finally the grand experiment of YES WE CAN. Once upon a time there was a man who believed in the empowerment of the masses and what those masses could accomplish. It is the belief at the center of Obama’s campaign. Regardless of what he says about the impact of Rev. Wright and attending TUCC, it raised his social consciousness. Working as a community organizer brought him face to face with the immediate need for social justice. It connected him to his black heritage in a very visceral way. When he says those years were the best education he got, believe him.
Justice for the disadvantaged is important for many reasons having nothing to do with morality. It makes sense economically, but also politically. When people are stuck in grinding poverty with no hope for a future then they will slowly move to the right. People who spend their time just trying to survive don’t have the time or energy to think about liberal causes, even if those causes would benefit them. Someone said “Right Gets It Wrong and the Left Doesn’t Get It.” Conservatives work to reduce welfare rolls by making harder and harder to get help and then not providing tools to move people off welfare into adequately paying jobs. The left conversely increases welfare rolls but also makes no provisions for the poor to be transitioned into the economic mainstream. Remember the bitter speech? Obama had it right. He understands poor and hopeless perhaps better than any presidential candidate since Bobby Kennedy. And like Bobby he feels it in his soul.
Obama learned community organizing with a model designed by Saul Alinsky. Alinsky is credited not only as the father of community organizing but for providing the foundation for grassroots political movements. He is famous for organizing the Back of the Yards, one of the poorest South Chicago neighborhoods located around the Union Stock Yards, and immortalized in Upton Sinclair’s powerful expose The Jungle. Alinsky’s focus was empowering people to gain power for social and political change and so it is with Obama. We see the lessons he learned on the mean streets of South Chicago as an organizer played out everyday in his campaign. Particularly in his ability to build coalitions between diverse groups for social change, 300 million Americans to move this country forward.
“We are concerned,” Alinsky elaborated, “with how to create mass organizations to seize power and give it to the people; to realize the democratic dream of equality, justice, peace, cooperation, equal and full opportunities for education, full and useful employment, health, and the creation of those circumstances in which men have the chance to live by the values that give meaning to life. We are talking about a mass power organization which will change the world…This means revolution.”
We are the one’s we have been waiting for. What a powerful, empowering, life affirming statement of hope and justice for all. The thought of empowering the masses is very radical politically. The conservative right hate it, believe it is Socialism, Marxism, Communism and very other negative “ism” they can attach to it. It is none of those things, but it is death to the status quo as we know it. It’s probably the closest we will ever get to government of the people, by the people and for the people. In fact this commonsense approach in solving social issues should be the political middle.
There is so much work to do, not just for our new President but for us a well. This will be the most difficult thing we have ever done. We will be forced by mutual goals to put our differences a side. Grow up, let go of our pettiness, we are all in this together. Don’t get me wrong, not expecting utopia even with success. But everyday that passes on this path puts us in a much better place to solve the problems we face. | <urn:uuid:db5f144a-4471-4975-8a05-6b761a553488> | CC-MAIN-2022-33 | https://www.docudharma.com/2008/06/social-justice-dont-shoot-the-messengers-the-grand-experiment-of-yes-we-can | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.973577 | 3,331 | 3.078125 | 3 |
The speed of biotechnology development is outpacing the ability of nations to legislate against it, a leading US bioterrorism expert will tell the AusBiotech 2003 conference, which starts in Adelaide, South Australia, on August 17.
AusBiotech 2003, one of the world's most significant biotechnology conferences, will this year address the role of the industry in safeguarding the world against abuse of biotechnology, whether through accident or deliberate acts of terror.
Michael Moodie -- co-founder and President of the US Chemical and Biological Arms Control Institute, based in Washington D.C. -- will tell over 1,200 Conference participants representing the most powerful bio companies in the world, that international regulation has not kept pace with biotechnology developments that threaten individual safety.
"International effort to deal with biological threats has not engaged private industry," Moodie believes. "The speed of developments in biotechnology are largely outpacing national and international attempts at legal and regulatory action to prevent such abuse.
"This situation will lead to a lack of effectiveness and ultimate downfall."
Attacks by air on the World Trade Center, the sarin gas released on the Tokyo subway by the Aum Shinrikyo, and the Sari Club bombing in Indonesia have focused attention on the growing threat of terrorist use of chemical, biological, radiological, or nuclear (CBRN) weapons.
The public health system would be especially stressed by a bioterrorist attack.
"Yet, that same public health system is the crucial factor in an effective response," Moodie said. "It will be the public health system that will be called on to mitigate and ameliorate the consequences of a terrorist attack using biological weapons."
AusBiotech Executive Director Dr. Tony Coulepis said that the biotechnology industry was well aware of the potential threats.
"Biotechnology has made extraordinary advances in the areas of public health, the food industry, and agriculture and the environment," Coulepis said. "However, as biotechnology becomes a borderless industry, chances increase for accident or misuse.
"The biotechnology industry in Australia and the US have shown a great willingness to collaborate on this topic and bioterrorism is a major item on the AusBiotech 2003 agenda."
The Chemical and Biological Arms Control Institute is a private, non-profit, non-partisan policy research organization established in 1993 to address the challenges posed by the complex interaction of security, science, and technology.
Before founding the institute, Moodie was Assistant Director for Multilateral Affairs at the U.S. Arms Control and Disarmament Agency (ACDA), where he was involved in the negotiations concluding the Chemical Weapons Convention and was also head of the U.S. delegation to the 1991 Biological Weapons Convention Review Conference. | <urn:uuid:f6bab481-216b-4be8-9bf7-06b739b979ec> | CC-MAIN-2022-33 | https://yenra.com/biotech-threats/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.933626 | 572 | 2.125 | 2 |
Cities Take Extreme Measures in Drought-Stricken West
Western cities take extreme water conservation measures as a multi-year drought drags on. Faced with water shortages, talk of future growth becomes controversial in the tourist boomtown of Santa Fe, N.M. Hear from NPR's John Burnett and NPR's Robert Siegel.
Copyright 2003 NPR | <urn:uuid:6f7f3f35-d232-491a-9c0c-f9c1f077fd96> | CC-MAIN-2022-33 | https://www.kazu.org/npr-news/2003-01-21/cities-take-extreme-measures-in-drought-stricken-west | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.880616 | 73 | 1.523438 | 2 |
Actually permissions are of 2 types:
1.Model level permissions
2.object level permissions
If you want to give permissions on all cars, then Model-level is appropriate, but if you Django to give permissions on a per-car basis you want Object-level. You may need both, and this isn't a problem as we'll see.
For Model permissions, Django will create permissions in the form 'appname.permissionname_modelname' for each model. If you have an app called 'drivers' with the Car model then one permission would be 'drivers.delete_car'. The permissions that Django automatically creates will be create, change, and delete.Read permission is not included in CRUD operation.Django decided to change CRUD's 'update' to 'change' for some reason. You can use the metaclass to add more permissions to a model.:
class Book( models.Model ): # model stuff here class Meta: permissions = ( ( "read_book", "Can read book" ), )
Permissions is a set of tuples, where the tuple items are the permission as described above and a description of that permission.
Finally, to check permissions, you can use has_perm:
obj.has_perm( 'drivers.read_car' )
Where obj is either a User or Group instance.
Here is some example which is used to check permissions 'perms' of a model object called entity in the app
def has_model_permissions( entity, model, perms, app ): for p in perms: if not entity.has_perm( "%s.%s_%s" % ( app, p, model.__name__ ) ): return False return True
Here entity is the Entity object to check permissions on (Group or User), model is the instance of a model(entity), perms is a list of permissions as strings to check (e.g. ['read', 'change']) for respective object, and app is the application name as a string. To do the same check as has_perm above you'd call something like this:
result = has_model_permissions( myuser, mycar, ['read'], 'drivers' )
We are having 3 default permissions which will be created when we run ./manage.py runserver.These permissions will be created for each models in a project.
With the help of model django.contrib.auth.models.Group,we can categorizing users so you can apply permissions to group(all users)...
For example, if the group Book, author has the permission can_edit_home_page, any user in that group will have that permission.
from myapp.models import Book from django.contrib.auth.models import Group, Permission from django.contrib.contenttypes.models import ContentType content_type = ContentType.objects.get_for_model(Book) permission = Permission.objects.create(codename='can_publish', name='Can Publish book', content_type=content_type)
We can directly add a permission to a user using user_permissions and to a group using permissions attribute.
Micropyramid is a software development and cloud consulting partner for enterprise businesses across the world. We work on python, Django, Salesforce, Angular, Reactjs, React Native, MySQL, PostgreSQL, Docker, Linux, Ansible, git, amazon web services. We are Amazon and salesforce consulting partner with 5 years of cloud architect experience. We develop e-commerce, retail, banking, machine learning, CMS, CRM web and mobile applications.
Django-CRM :Customer relationship management based on Django
Django-blog-it : django blog with complete customization and ready to use with one click installer Edit
Django-webpacker : A django compressor tool
Django-MFA : Multi Factor Authentication
Docker-box : Web Interface to manage full blown docker containers and imagesMore... | <urn:uuid:4e0c2332-87d9-4830-9ac6-f309ac9feb54> | CC-MAIN-2022-33 | https://micropyramid.com/blog/understanding-django-permissions-and-groups/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.794865 | 896 | 2.75 | 3 |
Keeping your cash safe: What new SEC rule means
Millions of investors use money market mutual funds to stash "cash" in their portfolios, since they're generally viewed as safe, convenient short-term investments — and there are major changes on the horizon designed to make them safer.
But are money funds the safest place for your cash? Many consumers don't know what distinguishes money market funds and money market accounts offered at their local bank or how to assess which is the safest place for their hard-earned dollars.
U.S. investors have parked nearly $3 trillion in money market mutual funds. Regulators have been tightening rules to make them safer in the wake of the mass exodus from these funds during the 2008 financial crisis. Last month, the Securities and Exchange Commission approved a new rule to help prevent a dramatic flight from these funds from happening again.
One portion of the new SEC rule is intended to better reflect the underlying value of money market mutual funds held by institutions and does not impact the money market funds that average investors own. Another portion of the new rule requires all money market funds (except government money market funds) to pose certain restrictions on withdrawals if there is a sharp decline in the amount of underlying investments in the fund that could easily be sold to raise cash.
While the new SEC rule is designed to prevent another stampede from money market funds, there is no impact on consumers who keep their stash of cash in their bank's money market account. They're not the same. Here are three main differences between money market funds and money market accounts:
Money market mutual funds are investments and are not insured. The funds invest in low-risk, highly-liquid investments like U.S. Treasury security (T-bills), certificates of deposit (CDs) and corporate commercial paper. They are regulated by the SEC and their value is determined by underlying investments, but they are not guaranteed investments.
Money market deposit accounts, like savings accounts, are FDIC insured. A money market account is like a "souped-up" savings account that can also invest your money in treasury notes, CDs and other short-term investments to give you a slightly better yield than a regular savings account. As with a savings account, the federal government insures your deposits in a money market account up to $250,000.
Money market account rates are currently better than money market fund yields. Historically, money market funds have had higher yields than bank deposits. But with interest rates so low, yields on money market funds after expenses are near zero. While the average yield on a money market fund is 0.01%, savings and money market account rates are about 0.10% on average. Some online banks offer money market account rates of almost a full percent, according to Bankrate.com.
Where is the safest place for your cash? It depends on how you'll use it.
If you need the money for emergencies — to pay household bills if you lose your job or fix the boiler or roof of your home — you may want to put those funds in a money market account at the bank.
On the other hand, if you want to keep some of your investment portfolio in "cash," a money market fund may be the easiest way to make sure you have funds on the sideline that can readily be moved into other investments.
For most investors, it's probably a good idea to have a little money in both.
© CNBC is a USA TODAY content partner offering financial news and commentary. Its content is produced independently of USA TODAY. | <urn:uuid:d73e6b54-b5a5-4ce8-b68c-150c031b3875> | CC-MAIN-2022-33 | https://www.usatoday.com/story/money/personalfinance/2014/08/16/cnbc-new-sec-rule/14115947/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.967569 | 721 | 2.21875 | 2 |
In a world completely inundated with information, where voices struggle to be heard over one another, it has become increasingly common that we marginalize the perspectives that deserve to be the loudest ones heard. In healthcare marketing, this translates to deprioritizing patient research.
This oversight is prevalent in many forms, across many topics, but what is most relevant to the healthcare market research industry is the limited representation of patients and the narrative of their treatment/journey through a medical condition.
For a long time, the collective focus has prioritized medical qualifications as an indication of the value that should be placed on an individual’s opinions. This prioritization needs to be readdressed and more weight given to the shared experiences of patients.
To say there’s no patient perspective in the research conducted today wouldn’t be entirely accurate. Patients are included in a lot of research, but less often are they the sole focus and target of research. We will often include patients in a sample, so we can say we acquired their perspective, but this is not the same thing as tailoring a questionnaire or a discussion guide to specifically uncover hidden gems in their very unique experiences.
Identifying market gaps through patient research
Gaps in the patient experience, while potentially small, is what patient journey research attempts to fill in. All conventional wisdom tells us that physicians, nurses and pharmacists are the primary targets of healthcare/pharmaceutical research. But the focus on patients in research allows us to:
- Highlight relevant gaps in the diagnosis to treatment journey.
- Uncover opportunities to capitalize on market shortcomings.
- Develop potential strategies to help companies become top of mind with customers.
- Discover why both patients and HCPs make the decisions that they ultimately do.
Through patient research, gaps in the diagnosis to treatment journey can present in different forms. For example, a gap in the necessary emotional support that patients with life-altering conditions will need in order to remain strong, or a gap in the sources of information available for patients to understand the types of treatments they’re being given, including a full understanding of short- and long-term side effects. This gap could also be something more obvious, such as patients not fully understanding how to take their medication, perhaps due to a unique method of application or a complex dosing system, not fully explained by the prescribing physician.
Patient gaps are everywhere in our healthcare system, and the main difficulty is that we usually don’t know that we have these gaps until we find out that we have them. Gaps are often unknown unknowns. A simple solution to this issue is to take steps to proactively dig deeper into patient perspectives whenever we can. If we give them a chance, patients will give us the information that we need to better serve them, no matter what their journey is.
Filling marketing gaps through patient research
In addition to being the right thing to do, getting a better understanding of the ultimate end customer, the patient, will allow pharmaceutical companies to capitalize on these market shortcomings (gaps) and develop well-informed strategies to maximize patient engagement.
Patient research can help marketers understand why patients make the decisions that they do, which is information that can set anyone apart from the competition. Why do patients overwhelmingly select one brand over another for an identical product? What are the best ways to reach a certain patient population with important product information? The potential is endless for patient journey research.
Implementing patient research
In your next research study, don’t be afraid to take the extra step to have a patient-focused phase of research in addition to your typical HCP sample. Very valuable medical insights can be gained from those who do not possess medical degrees, many times in a more cost-effective manner. We all understand how complex the healthcare system is in the United States. This complexity, if not completely mirrored, is present in other countries as well. Understanding how these different markets work together and individually is not only interesting, it’s crucial. As you think about the answers to the next big questions that you’ll face, it is important to remember: The most commonly sought out voices are not always the most insightful. | <urn:uuid:a7e30d35-057e-473d-8d2e-7f6f37647a7d> | CC-MAIN-2022-33 | https://www.addisonwhitney.com/insights/prioritizing-patient-focused-research/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.947978 | 864 | 1.976563 | 2 |
A shortage of IT skills, especially those that would allow agencies to operate and secure today’s cloud-enabled IT environments, are continuing to handicap agencies as government competes for younger talent, according to new research produced by FedScoop and WorkScoop.
Among the findings: 8 in 10 federal CIOs, budget and human capital officials surveyed said they are moderately or highly concerned about being able to replenish their IT staffs with a younger generation of talent who are trained on more modern tools.
Additionally, 1 in 3 respondents reported more than 10 percent of their full-time IT jobs are currently vacant; and 6 in 10 have at least some full-time positions open. Roughly 2 in 3 said IT vacancy rates are higher, or the same, compared to a year ago.
Roughly half of respondents cited the government’s complicated hiring process and the lack of focus around IT workforce planning as key constraints to improving the federal IT workforce.
The study surveyed 126 prequalified federal decision makers in IT, human resources and budget offices. It explores how the federal government can foster more effective IT workforce planning and development to meet mission goals.
The report, which was underwritten in part by Pluralsight, also highlighted the importance for agency executives to devote more attention to developing and sharing IT workforce development plans. Only half of agency leaders surveyed said their agency had an IT workforce development plant that aligned with their agency’s broader strategic goals.
Respondents identified multiple opportunities to improve IT workforce development, including:
- Support changes to the General Schedule to better align IT salaries with market norms.
- Provide funding to upskill and reskill.
- Revise IT descriptions to align with private sector jobs, based on capabilities versus qualifications.
The survey, conducted online in August amid the pandemic, found that widespread moves to allow federal employees to work remotely may lend longer-term support to looking farther afield for IT talent. Nearly half of respondents indicated that the pandemic presented officials with greater latitude at their agencies to hire remote IT workers to fill some of their skills needs.
“Agencies can improve the hiring and retaining of the workforce by creating more opportunities to work outside of DC — permanent telework, flexible remote work or with satellite offices in other locations,” according to one respondent in the report.
The report concludes that agency leaders should consider focusing more attention on five areas to help ease systemic constraints on hiring and developing needed IT skills in government, including:
- Prioritizing workforce development plans that align with agency strategies.
- Renewing pressure on OPM, Congress and the administration to address constraints in the GS schedule.
- Aligning job descriptions with today’s technology world and streamline the hiring process.
- Putting experience ahead of college degrees to provide wider recruitment opportunities.
- Providing more time and resources to upskill and reskill current employees.
Addressing these workforce challenges could significantly improve agencies ability to hire, retain or reskill to fill the IT skills they need now, and over the next two years. Those skills, identified in a prior study by FedScoop and WorkScoop, released earlier this year, included expertise in cloud-based computing, artificial intelligence, data analysis, enterprise engineering and DevOps.
Download the report, “Federal IT Workforce Planning: Opportunities and Obstacles” for detailed findings and guidance on IT workforce needs in the federal government.
This article was produced by FedScoop and WorkScoop, and underwritten in part by Pluralsight. | <urn:uuid:0eeb63f6-756e-4458-8442-f0abf8e50057> | CC-MAIN-2022-33 | https://www.fedscoop.com/remote-workers-reduce-federal-it-skills-deficit/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.945288 | 741 | 1.65625 | 2 |
If you don't have a suitable Quality Management System (QMS) or Factory Production Control (FPC) system, you need to install a FPC to provide traceability and proof of compliance with the various scheme requirements. You may wish to appoint a consultancy company to assist you with implementation of a suitable Factory Production Control (FPC) system.
You will need to get a BFRC approved assessment of the performance of the window range you wish to be WER labelled. A computer based simulation prepared by a BFRC Approved Simulator is normally used to assess the window range. It is based upon a standard window configuration which uses a window measuring 1480 mm high x 1230 mm wide, having a central divider with one opening light and one fixed light.
Once you have obtained simulation reports to provide evidence of the calculated Window Energy Ratings, the Independent Agency (IA) can then start the process of the factory production control assessment. During the visit to the manufacturer's premises, the IA will check through the simulation reports, confirm that the detailed components are those actually used to produce the relevant window then check the operation of the Quality or Factory Production Control system. When the IA is satisfied that the necessary requirements have been met, they will forward an information pack including details of the assessment to BFRC, who will process the application. On payment of their fees BFRC will then issue details of the WER labels to the window manufacturer and put information onto the BFRC website. The window manufacturer will now be able to start labelling products for sale into the market place.
If the BFRC approved assessment confirms the energy rating at B or above, an application may be made to use the Energy Savings Trust (EST) Energy saving recommended labelling. (please note that EST may wish to conduct a separate audit prior to entry into its scheme).
In future, regular audits will confirm that windows continue to be made and supplied in agreement with the original thermal simulations. An audit is then conducted at the manufacturer's premises to ensure the manufactured product relates to the particular technical specifications and that the manufacturer is operating an effective Quality Management System.
Window Installers or Window Retailers, as they are referred to by the BFRC, may also be able to obtain WER labels bearing their own name. Contact us for details. | <urn:uuid:4551213e-ca17-471f-89ff-877fd530df40> | CC-MAIN-2022-33 | https://www.er-certification.com/become-an-approved-supplier.htm | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.926003 | 466 | 1.890625 | 2 |
Models seem to have everything going on fine for them, what the rest of the world does not know is, a number of them are “big-time” victims of a poor mental health. However on the outside, everything looks glamorous, with some fans even working on replicating their lifestyles in every possible way. The models in question cannot begin to narrate what they have been through for as long as their mental health problem came into play. They understand how important their public image is, and hence, this problem must be concealed at all times.
The mental health of a models is a huge cause for concern, as the modelling industry is one which can create uncertainties and anxieties. For young models who are new in the industry, they must learn now to tackle this head-on, in order to adjust better when the going gets tough.
FACTORS WHICH CAUSE MENTAL HEALTH PROBLEMS IN THE MODELLING WORLD
ENDLESS REJECTION: One of the regular causes of mental health problems in models, is the endless rejection. No matter how good the result is, irrespective of the modelling category, criticism and rejection are bound to occur. This duo regularly affects models and shrinks their confidence, younger models are at greater risk of this.
THE SOCIAL MEDIA: For models, the number of followers on their social media accounts could be hurtful owing to the fact that they are expected to have plethora of followers. A lot of models crave attention from their fans on the social media and once they don’t receive such on a regular diet, the pain starts eating into them, which eventually leads to insecurity.
DISPOSABILITY: Models are aware of the fact that in the modelling world, no one is really indispensable. There would be a time when younger models would replace the older ones, and the cycle goes on and on in the same way. Hence, awaiting when you would no longer be relevant often causes uneasiness. As new faces emerge in the modelling world, the older faces see this as a threat which cannot be combatted, and hence mental health problem sets in.
For successful models in the modelling world, sharing their story and experience openly, would encourage and motivate models who are still actively engaged. Also, models who are struggling with mental health problems are advised to visit a health specialist before it gets out of hand. | <urn:uuid:38b57435-cce7-4ad8-9688-6780d0212a1f> | CC-MAIN-2022-33 | http://afloridastar.com/mental-health-problems-in-the-modelling-world/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.968505 | 488 | 2.125 | 2 |
Stacy Borans is a doctor herself. She knows all about healthy eating. But she had never been able to lose weight with a diet — or diet pills.
"I got into the, 'Nothing's ever going to work for me. And I'm just, you know, going to give up,'" she says, laughing.
So she enrolled in a study at the University of Pennsylvania that used a combination approach, and she lost 60 pounds.
Tom Wadden, Ph.D., is the director of the Weight and Eating Disorders Program at the University of Pennsylvania.
"The mistake that has been made," saysWadden, "is that people expect the medications to act alone without an individual trying to change their diet and physical activity."
The study combined a weight loss drug called Meridia, which has been on the market for eight years with modest success, and a behavior modification program in which people attended counseling sessions to change their eating habits, such as taking smaller portions.
Over a year, people who just took the drug lost an average of 11 pounds. Those enrolled in behavioral modification alone lost 13 pounds. But those who got both lost 27 pounds.
Borans says that the counseling sessions, along with a food journal, made it easier to lose weight.
"I think it keeps you honest," says Borans, "And so it's harder to cheat when you're doing that."
She says the drug has also been critical for keeping the weight off, adding, "It eliminated a lot of the cravings for chocolate and french fries and, you know, pizza."
Weight loss drugs have a troubled history. Amphetamines can be addictive. Fen-Phen caused heart problems. But experts says Meridia could be the first of a new generation of weight loss medicines that could prove safe — and effective — especially when combined with proper dieting and exercise. | <urn:uuid:766caf53-1aae-4f51-944e-0d952c54aa13> | CC-MAIN-2022-33 | https://www.nbcnews.com/id/wbna10073826 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.979622 | 384 | 2.171875 | 2 |
One of the key elements in proving a negligence claim in Alabama is establishing whether the offending party had a duty to the plaintiff.What that means it that the law recognizes that due to the establishment of a relationship between the defendant and the plaintiff, the defendant was obligated to act in a certain manner toward the plaintiff. It could be a duty to protect. It could be a duty to care. It could be a duty to control or a duty to rescue.
If the court finds that such a duty exists, then the plaintiff can pursue the issue of whether that duty was breached.
However, establishing that duty is not always easy, as recently highlighted in the case of Bell v. Dawson, reviewed by the Maine Supreme Judicial Court. Although this is an out-of-state case, many of the same legal elements apply.
The facts of the case start out as so many other Montgomery injury cases do: With the injury of a minor child. Here, the minor was 13-years-old and was seriously injured while skating out of a driveway belonging to the defendant. The youth was subsequently struck in the roadway by a moving vehicle.
The boy’s mother brought a negligence claim on his behalf against the defendants, alleging they had provided negligent supervision and also that they had negligently created an inherent danger on their property by failing to adequately trim the vegetation, which created a visual obstruction for both those coming out of the driveway and those passing by it.
The superior court granted a summary judgment in favor of the defendants, finding that the plaintiff in this case failed to establish that the defendants had any duty of care to her son. The court found that the defendants owed no duty of care to the youth because they were not in a custodial relationship with the boy at the time of the accident. The court also dismissed the claim of overgrown vegetation because there was no indication in the accident reports that this had played any role in the incident.
The defendants’ home in this case was a popular hang-out spot for young teens in the neighborhood. They would go there to smoke cigarettes and sometimes drink alcohol, despite being underage. The evening before the incident, the defendants agreed to allow the 13-year-old and several other boys to stay at their house, even though they weren’t in a position to supervise. The youth called his mother, told her he was staying at a friend’s home, when in fact he was staying with the defendants. The female half even phoned the boy’s mother, pretending to be the other child’s mother, so that he would be allowed to stay.
The defendants went to bed later that night, and the 13-year-old left the house around 1 a.m. He did not return until about 4 a.m. He then returned to his home around 7 a.m., stayed for about 20 minutes, talked with his parents and then left again on his skateboard, saying he was going to find his friend.
At some point thereafter, he returned to the home belonging to the defendants. He then road his skateboard out of their driveway, at which point he was struck by a vehicle and sustained serious injuries.
While there is no question that the defendants’ actions the night before were irresponsible, the court found that because the boy had left the property prior to the incident and returned home, they were not technically in a supervisory relationship with him at the time of the crash. Had the incident happened before the boy returned home, this likely would have been a very different case, as the duty of care could have been established via the defendants’ agreement to allow the minor child to stay at their home for the night.
However, the court found that the defendants’ duty of care ended when he left their property and returned to his home that morning.
Call Allred & Allred P.C. at 334.396.9200 to speak with a personal injury attorney today. | <urn:uuid:689b4a5a-5b10-4069-ac77-45f4199e40ea> | CC-MAIN-2022-33 | https://www.alabama-injury-lawyer-blog.com/bell-v-dawson-and-establishing/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.988188 | 811 | 1.570313 | 2 |
ORIGINAL RESEARCH article
Sec. Cancer Genetics
Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients
- 1Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon
- 2Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- 3Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
- 4Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
- 5Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
- 6Outcomes Research Unit, American University of Beirut Medical Center, Beirut, Lebanon
- 7Neurogenetics Program, Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
Breast cancer is the most common cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. CLN3 protein (CLN3p), deficient in neurodegenerative CLN3 disease is anti-apoptotic, and defects in the CLN3 gene cause accelerated apoptosis of neurons in CLN3 disease and up-regulation of ceramide. Dysregulated apoptotic pathways are often implicated in the development of the oncogenic phenotype. Predictably, CLN3 mRNA expression and CLN3 protein were up-regulated in a number of human and murine breast cancer-cell lines. Here, we determine CLN3 expression in non-tumor vs. tumor samples from fresh and formalin-fixed/paraffin-embedded (FFPE) breast tissue and analyze the association between CLN3 overexpression and different clinicopathological characteristics of breast cancer patients. Additionally, gene expression of 28 enzymes involved in sphingolipid metabolism was determined. CLN3 mRNA is overexpressed in tumor vs. non-tumor breast tissue from FFPE and fresh samples, as well as in mouse MCF7 breast cancer compared to MCF10A normal cells. Of the clinicopathological characteristics of tumor grade, age, menopause status, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), only absence of HER2 expression correlated with CLN3 overexpression. Sphingolipid genes for ceramide synthases 2 and 6 (CerS2; CerS6), delta(4)-desaturase sphingolipid 2 (DEGS2), and acidic sphingomyelinase (SMPD1) displayed higher expression levels in breast cancer vs. control tissue, whereas ceramide galactosyltransferase (UGT8) was underexpressed in breast cancer samples. CLN3 may be a novel molecular target for cancer drug discovery with the goal of modulation of ceramide pathways.
Globally, about 1.38 million women are diagnosed with breast cancer and 458,503 die from the disease every year (1). The incidence is rising in low-income and middle-income countries, a trend attributed to improved life expectancy, urbanization, and adoption of a Western diet and lifestyle (2–4). In Lebanon, breast cancer is now the leading cancer among women (5, 6) and contributes to 45% of annual registered deaths (5). Breast cancer in Lebanon manifests larger tumor size, more lymph node involvement, and higher tumor grades (7, 8).
CLN3p impacts cell–cell communication, apoptosis and autophagy, proper functioning of lysosomes, and galactosylceramide (GalCer) lipid transport from Golgi to lipid rafts in the plasma membrane (9). Defects in this gene lead to Juvenile Neuronal Ceroid Lipofuscinosis or CLN3 disease, a pediatric neurodegenerative disease (10). In CLN3 disease, defective or low levels of CLN3p lead to failure of GalCer transport to lipid rafts, thus impairing lipid raft function, and resulting in toxic increases in ceramide (9). This process leads to enhanced apoptosis of neurons and photoreceptors initiated via caspase-8 activation (9, 11).
Cancer and neurodegeneration are often two sides of the same coin. Low levels of CLN3p lead to neurodegeneration and enhanced apoptosis, and high levels of CLN3p may lead to inhibition of apoptosis, cellular proliferation, and carcinogenesis. The expression of CLN3 mRNA and CLN3 protein is increased in a variety of cancers, including prostate, ovarian, colon, glioblastoma, and, human breast cancer-cell lines and solid colon cancer (Figure S1 in Supplementary Material) (12). High levels of CLN3 are linked to inhibition of apoptosis by negatively impacting ceramide generation upstream (11, 13). Moreover, blocking CLN3 expression using anti-sense strategies led to cancer-cell killing, suggesting CLN3p may be a potential therapeutic target (12).
There is increasing evidence for the involvement of sphingolipid signaling in breast cancer (14). Sphingolipids are a family of lipids lending structural support to the membrane bilayer (15). Also, sphingolipid-regulated functions have significant and specific links to various aspects of cancer initiation, progression, and response to anticancer treatments. Ceramide, in particular, is intimately involved in the regulation of cancer-cell growth, differentiation, senescence, and apoptosis (16).
In this study, levels of CLN3 expression in 75 paired invasive ductal carcinomas (IDC) and their corresponding non-tumor freshly dissected breast tissues and another 189 breast cancer tissue paraffin blocks and corresponding normal tissue paraffin blocks from the same patient are compared by quantitative real-time polymerase chain reaction (qRT-PCR). The association of CLN3 expression with specific clinicopathological characteristics of breast cancer patients is documented. In addition, gene expression of enzymes controlling sphingolipid metabolism in fresh-frozen breast cancer tissues is established, confirming the CLN3-ceramide link.
Materials and Methods
A total of 75 patients with IDC of the breast were subjected to surgical resection at the American University of Beirut Medical Center, between September 2012 and May 2014. Fresh breast cancer and corresponding non-tumor breast samples were collected and stored in RNAlater™ (Qiagen) at −20°C. AUB-IRB (American University of Beirut – Institutional Review Board) approved our study (IRB number: IM.AT.05, last updated on May 27th, 2013). Written informed consent was obtained from patients following this AUB-IRB-approved protocol, and in accordance with the Declaration of Helsinki. Additionally, formalin-fixed/paraffin-embedded (FFPE) breast tissue blocks from 7 patients who underwent reduction mammoplasty and from 189 patients (paired IDC and their corresponding non-tumor breast tissue blocks) were obtained from the Department of Pathology of the American University of Beirut Medical Center, also under an AUB-IRB-approved protocol. All samples were used for detection of CLN3 mRNA expression. Patient clinicopathological characteristics were tabulated, including tumor grade, age, menopause, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status.
mRNA Expression Levels
Formalin-fixed/paraffin-embedded tissue samples were cut into 20 μm × 10 μm sections to be included per extraction. FFPE sections were deparaffinized using xylene and lysed overnight in proteinase K. Then, mRNA was extracted using the RiboZol™ RNA Extraction Reagent (Amresco) according to the manufacturer instructions. RNA was eluted in nuclease-free water and stored at −80°C until use. RNA was treated with DNase enzyme (Fermentas) to remove genomic DNA. Using RNeasy® Plus Mini Kit (Qiagen), total RNA was extracted from human fresh breast tissues, according to the manufacturer’s protocol. For assessing RNA quality and yield, A260/A280 and A260/A230 ratios for RNA were analyzed with a NanoDrop® ND-1000 spectrophotometer (NanoDrop Technologies) and Experion™ Automated Electrophoresis System (BioRad), respectively.
RNA was reverse transcribed using RevertAid Reverse Transcriptase (Thermo Scientific) with 100–1000 ng of input RNA and random primers (Thermo Scientific). Quantitative real-time PCR reactions were performed in 96-well plates using specific primers (TIB MOLBIOL) and the iQ™ SYBR® Green Supermix (BioRad) as a fluorescent detection dye, in CFX96™ Real-Time PCR (BioRad), in a final volume of 12.5 μl. To characterize generated amplicons and to control contamination by unspecific by-products, melt-curve analysis is applied. Each reaction was performed in duplicate. All results were normalized to PGK1 mRNA level and calculated using the ΔΔCT method. The specificity of the PCR was determined by melt-curve analysis for each reaction. Primer sequences are listed in Table S1 in Supplementary Material (Tm = 60°C).
Human breast adenocarcinoma or MCF7 cells (ATCC) were grown at 37°C under 5% CO2 in RPMI 1640 medium supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 1% penicillin–streptomycin. Human breast epithelial or MCF10A cells (ATCC) were maintained at 37°C in a humidified atmosphere of 5% CO2/95% air in DMEM/F12 medium supplemented with 5% heat-inactivated horse serum, 10 μg/ml insulin, and 100 mg/ml Cholera toxin, 0.5 μg/ml hydrocortisone, 20 ng/ml recombinant EGF, and 1% penicillin–streptomycin. Medium was changed every 2 days, and cells were split every week.
siRNA CLN3 Knockdown
siRNA for CLN3 knockdown (BLOCK-iT RNA™ Designer, Invitrogen) or scrambled control were transfected into MCF7 cells (HiPerfect Transfection, Qiagen). Cell pellets are collected on day 4 to measure ceramide levels using the diacylglycerol kinase (DGK) assay. For validation of CLN3 knockdown, quantitative real-time PCR reactions were performed. Results were normalized to Cyclophyllin A mRNA level and calculated using the ΔΔCT method. Primer sequences are listed in Table S1 in Supplementary Material (Tm = 60°C).
Trypan Blue Dye Exclusion Method
Cell growth and viability was determined using trypan blue dye exclusion. About 100,000 MCF7 cells are seeded per well and transfected with CLN3 siRNA/scrambled siRNA. After 96 h, cells were washed, centrifuged, and fresh media added. The cells are then stained with trypan blue dye (0.4%) and the number of white viable and dead blue cells is counted using a light microscope and a hemocytometer.
Propidium Iodide Staining
About 100,000 MCF7 cells are transfected with CLN3 siRNA/scrambled siRNA, suspended in 100 μl PBS, incubated with 100 μl/0.5 mg/ml PI, washed, placed on slides, and viewed with a fluorescent microscope. Cells are harvested 72 and 96 h after transfection. Three hundred cells in three different fields of vision were counted, and percentage of red staining apoptotic cells/total cells determined.
Measurement of Ceramide Levels
Cell pellets were collected and washed with PBS, then suspended in methanol/chloroform (2:1) and stored at −80°C for 48 h.
Seven hundred microliters of distilled water are added to the homogenate, then 1 ml chloroform and 1 ml of distilled water, and the sample centrifuged for 10 min at 4°C. The lower phase is lyophilized. Lipids are resuspended in 1 ml chloroform.
Ceramide standards and samples are dried using a speedvac. Micelles were added to samples/standards and sonicated for three cycles of 30 min each. Reaction mixtures are added to the ATP mix and incubated at RT for 45 min. The reaction is stopped using methanol/chloroform/distilled water, then lipids extracted. These are run on a TLC plate using chloroform/acetone/methanol/acetic acid/water (50:20:15:10:5). Plates are then dried, x-ray film overlaid and kept at −80°C overnight. Ceramide bands are visualized, scraped into scintillation vials, and counts per minute detected using a liquid scintillation counter. The results are expressed as picomoles of ceramide per nanomole of total phospholipids.
After lyophilization, 150 μl of 70% perchloric acid are added to samples and to disodium hydrogen phosphate (Na2HPO4) standards. Tubes are capped with glass balls previously soaked in methanol and placed at 180°C for 1 h, cooled at RT and distilled water/2.5% ammonium molybdate/10% ascorbic acid added. Mixtures are incubated for 15 min at 50°C, and concentration determined with a spectrophotometer (820 nm wavelength).
Microarray Expression Profiling and Data Analysis
Gene expression analysis was performed on 94 fresh breast tissue samples (84 cancerous and 10 normal) using the GeneChip Human Genome U133 Plus 2.0 arrays (Affymetrix Inc.) representing over 45,000 transcripts. Samples were prepared and microarrays were processed using the GeneChip 3′IVT Express kit as instructed by the manufacturer. Briefly, 100 ng of total RNA are fragmented then hybridized to the arrays. After washing and staining using the GeneChip Fluidics Station 450, the arrays are scanned with the GeneChip Scanner 3000 7G. Cell intensity data (CEL) files are generated with the Affymetrix GeneChip Command Console (AGCC) software version 3.2.
Data were analyzed within the R statistical environment (17) using Bioconductor (http://www.bioconductor.org) packages. Stringent quality control criteria were applied to the data. Three samples were found to be of a low quality and were excluded of subsequent analyses. Data were normalized jointly with the Robust Multiarray Average (RMA) algorithm (18).
Where more than one probe was found to match the same gene the mean expression value was calculated and used. Expression boxplots for the genes of interest of tumor against normal samples were generated from this expression matrix.
To detect differentially expressed genes between tumor and normal samples, Limma (19) was used to fit a linear model to normalized expression data for each probe. False discovery rates (FDRs) were estimated using the Benjamini–Hochberg method (20).
CLN3 mRNA expression was quantified in breast adenocarcinomas and overexpression was defined as a 1.25-fold increase in expression compared to normal tissue. Continuous data were expressed as means ± SEM, whereas categorical data were summarized as counts and percents. The chi-square (χ2) test for categorical variables was used to determine the association between gene expression levels and clinicopathological characteristics. Means of continuous data were compared by the two-tailed Student’s t-test. For multiple group comparisons, two-way ANOVA followed by Bonferroni’s correction was used. Gene expression data derived by Affymetrix or real-time PCR were compared for tumor vs. normal tissue by standard t-test. The concordance or discordance between normal breast tissue adjacent to the tumor and normal breast tissue from reduction mammoplasties was analyzed using the kappa (κ) test of concordance. Concordances of <0.40, 0.40–0.75, and >0.75 were defined as poor, moderate, and perfect, respectively.
SPSS statistical software version 21.0 (SPSS Inc., Chicago, IL, USA) was used for analysis, except for the Affymetrix expression data that were analyzed using R statistical environment. All tests were two-sided and p < 0.05 was considered as a statistically significant difference.
Of the 189 patient malignant FFPE tissues from breast adenocarcinomas, only 175 had corresponding non-tumor FFPE tissue. Of these 175 patients, 21, 49, 51, and 54 patients had Ductal Carcinoma In Situ (DCIS), or IDC grades I, II, and III, respectively. A total of 26 were <40 years, 56 were between 40 and 49 years, 66 were between 50 and 69 years, 22 were >70 years old. In five patients, age was undetermined. Eighty-three were menopausal, 87 were premenopausal and menopausal status was undetermined in 5 patients. ER was positive in 128 patients, negative in 31. Information on another 16 patients was not available. PR was positive in 105, negative in 51, and undetermined in 19 patients. Thirty-two were HER2 positive, 108 were HER2 negative and information on an additional 35 patients was not available.
The malignant FFPE tissue from 189 patients was compared to non-tumor FFPE tissue collected from 7 reduction mammoplasties. Of those, 22, 50, 57, and 60 patients had DCIS, and IDC grades I, II, and III, respectively. A total of 29 were <40 years, 58 were between 40 and 49 years, 68 were between 50 and 69 years, 28 were >70 years old, whereas in 6 patients, age was undetermined. Ninety-one were menopausal, 92 were premenopausal and menopausal status was undetermined in 6 patients. ER was positive in 139 and negative in 33 patients. Information on 17 patients was not available. PR was positive in 114, negative in 55 and undetermined in 20 patients. Thirty-five were HER2 positive and 117 patients were HER2 negative. Information on 37 patients was not available. Clinical characteristics of the patients are summarized in Table 1.
Table 1. Relationship between CLN3 mRNA overexpression and patient clinicopathological parameters of the FFPE breast carcinoma tissue.
Patient clinicopathological characteristics and their frequencies from IDC of the breast and non-tumor tissue (from same patient or from reduction mammoplasties) were compared. The table also displays the frequency distribution and percentage of the two variables: CLN3 overexpression and patient clinicopathological characteristics. Statistics were calculated by the Pearson χ2 test and undetermined samples were not included. CLN3 expression levels were analyzed by comparing malignant tissue from breast adenocarcinomas to corresponding non-tumor tissue. The cut-off point for CLN3 overexpression was a 1.25-fold increase. A p < 0.05 was considered as statistically significant.
CLN3 Gene Expression
To determine the potential role of CLN3 in the development and progression of IDC of the breast, 75 paired fresh tumor tissues and 189 paired FFPE IDC breast samples were collected and characterized for the relative levels of CLN3 mRNA transcripts by qRT-PCR. When comparing FFPE IDC breast samples to the corresponding non-tumor tissue, 38% of the DCIS cases showed overexpression of the CLN3 gene. Overexpression of CLN3 was highest in IDC grade I (49%). CLN3 expression was less prevalent in IDC grade II (41%) and even less in IDC grade III (35%). When comparing IDC breast samples to non-tumor tissue from reduction mammoplasty patients, overexpression of CLN3 was most prevalent for IDC grades I and II (54%), and 50% in DCIS and also 50% in IDC grade III. There is an increase in percentages of CLN3 overexpression when tumor tissue is compared to tissue from reduction mammoplasties as opposed to normal tissue from the same patient removed at surgery (Figure 1A).
Figure 1. Expression of CLN3 in breast adenocarcinoma samples (A) FFPE breast cancer tissue of different tumor grades (DCIS, IDC grades I, II, and III) were collected with surrounding normal tissue and normal tissue from reduction mammoplasties. Total RNA was extracted and quantitative real-time PCR experiments were performed using primers for the CLN3 gene. The RT-PCR was normalized using PGK1 RNA. The cut-off point for CLN3 overexpression was a 1.25-fold increase. (B) Fresh and FFPE breast tissue of different tumor grades (DCIS, IDC grades I, II, and III) were collected with surrounding normal tissue. Total RNA was extracted and quantitative real-time PCR experiments were performed using primers for the CLN3 gene. The RT-PCR was normalized using PGK1 RNA. The cut-off point for CLN3 overexpression was a 1.25-fold increase.
Also in fresh tissue, 50% of IDC grade I cases showed overexpression of the CLN3 gene. Prevalence of CLN3 overexpression is highest in IDC grade II (67%), followed by a decrease in IDC grade III (44%). Note the difference in percentages of CLN3 overexpression in FFPE tissue (49, 41, and 35%) for IDC grades I, II, and III, respectively. Higher percentages of CLN3 overexpression are observed in fresh breast tissue, as compared to FFPE tissue (Figure 1B).
CLN3 Gene Expression Levels and Clinicopathological Characteristics
CLN3 overexpression did not correlate with lower or higher tumor grade, age, menopausal status, ER, PR, and HER2 expression, when comparing the level of CLN3 mRNA between breast cancer and the surrounding non-tumor tissue (Table 1).
When comparing cancerous tissue to non-tumor tissue from reduction mammoplasties, no positive correlation was observed with respect to CLN3 overexpression and higher tumor grades, age, and menopause status. Similarly, there was no significant difference in CLN3 overexpression between patients with negative or positive ER and PR status. CLN3 overexpression in patients with no HER2 expression was significantly higher compared to those with positive HER2 breast cancer (p = 0.045) (Table 1). In fact, the cross-tabulation displaying the frequency distribution of the two variables (CLN3 mRNA expression and HER2 status) shows that when HER2 is not expressed, CLN3 is overexpressed in 66/117 (56%) of cases, whereas, when HER2 is overexpressed, CLN3 is overexpressed in only 13/35 (37%) of cases (Table 1). So, 56% of breast cancer patients that exhibit overexpression of CLN3 mRNA lack HER2 expression compared to only 37% overexpressing HER2 (Figure S2A in Supplementary Material). Fifteen percent of those cases overexpressing CLN3 and lacking HER2 receptor are triple negative (HER2/ER/PR negative) and 85% are ER/PR positive (Figure S2B in Supplementary Material).
Growth, Apoptosis Rate, and Ceramide Levels in CLN3-Deficient MCF7 Cells
CLN3 mRNA is overexpressed 3.5-fold in MCF7 cells compared to MCF10A cells, making MCF7 cells an excellent in vitro model to study the impact of CLN3 expression in breast cancer (Figure 2A). A significant blocking of CLN3 protein expression using CLN3 siRNA was achieved in MCF7 cells. Blocking CLN3 expression inhibited growth and viability of MCF7 cancer cells (Figure 2B), and increased apoptosis as shown by PI staining (Figure 2C). Previous work had shown that CLN3 negatively modulates ceramide generation in NT2 cells that are human teratocarcinoma-derived progenitor cells (21). Threefold higher levels of endogenous ceramide were observed after MCF7 cells were transfected with siRNA directed against CLN3 compared with control MCF7 cells transfected with scrambled siRNA (Figure 2D).
Figure 2. CLN3 expression, growth, apoptosis rate, and ceramide level in MCF7 cells. (A) Total RNA was extracted from MCF7 and MCF10A cells and quantitative real-time PCR experiments were performed using primers for the CLN3 gene. The RT-PCR was normalized using Cyclophyllin A and the results represent the mean ± SEM of at least three independent experiments. *p < 0.05 by two-tailed Student’s t-test. (B) MCF7 cells were transfected with scrambled siRNA or with siRNA directed against CLN3 (siCLN3) for 4 days. Live cells were counted in triplicates at different time points. The results represent the mean ± SEM of at least three independent experiments. *p < 0.05 and ****p < 0.0001 by two-way ANOVA followed by Bonferroni post test. (C) Propidium iodide positive cells were counted at different time points. The results represent the mean ± SEM of three independent experiments. **p < 0.01 and ***p < 0.001 by two-way ANOVA followed by Bonferroni post test. (D) Ceramide levels are higher in cells transfected with siCLN3 as compared to those transfected with scrambled siRNA.
Expression of Genes Involved in Sphingolipid Metabolism
We used Affymetrix GeneChip Human Genome U133 Plus 2.0 expression arrays to determine differences in the mRNA expression of 28 genes involved in sphingolipid metabolism (Table S2 in Supplementary Material), in 83 cases of invasive breast cancer in fresh tissue compared to 8 non-tumor fresh breast tissue samples. Significant differences in the expression of several genes were observed in tumor samples vs. controls. Ceramide synthase 2 (CerS2) expression was 5-fold increased (p = 0.026), ceramide synthase 6 (CerS6) was 13.8-fold increased (p = 0.001), delta(4)-desaturase sphingolipid 2 (DEGS2) was 5.5-fold increased (p = 0.046), and acid sphingomyelinase (SMPD1) was increased 1.66-fold (p = 0.013). Neuronal Ceroid Lipofuscinosis 3 (CLN3) expression was also increased 3-fold (p = 0.077) and ceramide galactosyltransferase (UGT8) was 19.8-fold decreased (p = 0.064), with an adjusted p-value close to significance (Figure 3A).
Figure 3. Tumor status and expression of genes of interest. (A) Box plots of six genes of interest (CerS2, CerS6, DEGS2, SMPD1, CLN3, and UGT8) coding for enzymes involved in sphingolipid metabolism with differences in expression between normal and tumor tissue samples. The line in the middle of the boxplots represents the median in normal and tumor samples. *p < 0.05 was considered as statistically significant. (B) Relative mRNA expression was measured by RT-PCR. The following genes related to sphingolipid metabolism are ceramide synthase 2 (CerS2), ceramide synthase 6 (CerS6), delta(4)-desaturase sphingolipid 2 (DEGS2), acid sphingomyelinase (SMPD1), Neuronal Ceroid Lipofuscinosis 3 (CLN3), and ceramide galactosyltransferase (UGT8). Values are means of the fold changes normalized to PGK1 mRNA expression, with their SEs represented by vertical bars. *p < 0.05 by Student’s t-test (n = 34).
Validation of Microarray Analysis Results with qRT-PCR
The differential expression of the six selected genes was examined using qRT-PCR: CerS2, CerS6, DEGS2, SMPD1, CLN3, and UGT8. Results exhibited high consistency with those of the microarray analysis. Tumor status induced a significant increase in the expression of CerS2 (p < 0.0001), CerS6 (p < 0.0001), DEGS2 (p < 0.0001), SMPD1 (p < 0.05), and CLN3 (p < 0.0001); and a significant decrease in the expression of UGT8 (p < 0.0001) compared with expression in the corresponding non-tumor tissue (Figure 3B).
In this study, CLN3 mRNA expression levels in breast cancer patient FFPE and fresh tissue samples were determined and association with patient characteristics established. The relative overexpression of CLN3 mRNA transcripts in IDC breast FFPE and fresh tissues was significantly higher than in surrounding control non-tumor tissues or in control non-tumor tissue from reduction mammoplasties. Furthermore, of the six clinicopathological parameters studied (tumor grade, age, menopause status, ER, PR, and HER2), CLN3 overexpression was significantly associated with absence of HER2 expression (p = 0.045) in patients with IDC of the breast (Table 2).
Receptor status is used as a guide to classify breast cancers into four biological subtypes: (a) low grade luminal A subtype, (b) high grade luminal B subtype (High grade, ER/PR positive or HER2+/ER+/PR+), (c) HER2 subtype (HER2+/ER−/PR−), and (d) triple negative/basal like subtype (HER2−/ER−/PR−) (22). So, the subtypes that are negative for HER2 receptor are luminal A, accounting for approximately 40% of all breast cancers and triple negative/basal like tumors that represent 10–20% of breast cancers and are negative, for all receptors. Lack of receptors limits the use of targeted treatments, such as hormonal therapy and anti-HER-2 agents, leading to a high proportion of disease-related death. The Human HER2 oncogene, also known as neu/c-erbB2, is responsible for encoding a 185-kDa transmembrane receptor tyrosine kinase overexpressed in 20–30% of breast cancers and is associated with increased breast cancer recurrence and a worse prognosis (23). It is a member of the epidermal growth factor (EGF) receptor (EGFR) family. The use of trastuzumab (Herceptin®), a humanized monoclonal antibody to the HER2 extracellular domain, improves survival in both early and metastatic HER2-positive patients (24, 25). HER2 expression in breast cancer is associated with poor prognosis (26). Elevated expression of the CLN3 gene in breast cancer was significantly associated with HER2-negativity, when comparing cancerous to non-tumor tissue from reduction mammoplasties. Interestingly, only 15% of the cases overexpressing CLN3 and lacking HER2 receptor are triple negative (HER2/ER/PR negative) and 85% are ER/PR positive, indicating that up-regulated CLN3 could be a good prognostic factor in HER2-negative breast cancers, suggesting a broad application of CLN3 targeted therapies in breast cancers that do not overexpress HER2. To address the extent to which CLN3 could be a prognostic factor in breast cancer, the correlation between CLN3 expression and clinical disease outcomes, such as survival, recurrence, and metastasis, in different subtypes of breast cancer, would still need to be assessed.
Defects or diminished CLN3 protein expression in the juvenile form of CLN3 disease is associated with increased levels of the pro-apoptotic sphingolipid ceramide in brains and cells from these patients. Sphingolipids are bioactive lipids that play roles in the structure and regulation of cellular membranes, and also impact signaling acting as protagonists in neurodegenerative disease, inflammatory disease and cancer (27). Alterations in sphingolipid metabolism also contribute to chemoresistance and tumor survival (28). The central character in the sphingolipid pathway is ceramide. It is either synthesized de novo from serine and palmitate or generated by breakdown of sphingomyelin via different sphingomyelinases (29) (Figure 4). Of the different functions attributed to ceramide, special attention has been given to its pro-apoptotic properties (30), and its significance as a potential target for cancer chemotherapy (31). Previous work has shown that CLN3 is anti-apoptotic, and that diminishing levels of CLN3 protein in cancer cells enhances ceramide production and results in death of cancer cells (21). Ceramide is also produced in response to stress stimuli, including some chemotherapeutic drugs and irradiation (16). The cell death function of ceramide suggests that ceramide analogs may open doors to new therapies to battle cancer. Thus, finding ways to increase ceramide by exogenous treatment or by elevating endogenous ceramide in cancer cells becomes desirable. The role of sphingolipid signaling in HER2-negative breast cancer, however, is not yet well-defined.
Figure 4. Overview of ceramide metabolism. Substrates and intermediates in the metabolism of ceramide are schematically shown and the respective enzyme names are stated next to the arrows. Enzymes overexpressed in tumor vs. normal samples are shown in green, and the ones underexpressed are shown in red.
We investigated whether a correlation exists between several elements of sphingolipid metabolism and tumor status in breast cancer in fresh tissue samples. Significant differences in tumor vs. control non-tumor tissue in the expression of many genes involved in this pathway were found. Ceramide synthase 2 (CerS2), ceramide synthase 6 (CerS6), delta(4)-desaturase, sphingolipid 2 (DEGS2), and acid sphingomyelinase (SMPD1) displayed higher expression in tumor samples. The alteration of these four enzymes may have several implications. First, dihydroceramide synthases (CerS2 and CerS6) acylate sphinganine and sphingosine to form dihydroceramide and ceramide, respectively (Figure 4). Erez-Roman et al. also determined that CerS2 and CerS6 mRNA expression is higher in human breast cancer tissue compared to paired normal tissue from the same patients (32). The hypothesis that higher levels of dihydroceramide synthases would directly or indirectly lead to higher levels of ceramide in tumor tissue may be an attempt to achieve a more efficient killing of cancer cells. The third enzyme dihydroceramide destaurase (DEGS) is responsible for the conversion of dihydroceramides generated via de novo biosynthesis to ceramides by the incorporation of a 4,5-trans-double bond, a process occurring within the endoplasmic reticulum (33) (Figure 4). The indirect augmentation of dihydroceramides by siRNA blockade of DEGS1 or DEGS2 decreased cell proliferation (34). Inhibition of DEGS1 with siRNA in human neuroblastoma cells leads to the accumulation of endogenous dihydroceramides with subsequent effects on cell growth, particularly cell cycle arrest (35). The enzyme acid sphingomyelinase (SMase) catalyzes hydrolysis of sphingomyelin to ceramide and phosphocholine (Figure 4). To date, four SMases have been identified. SMPD1 encodes lysosomal acidic SMase, and three neutral SMases are coded for by SMPD2, SMPD3, and SMPD4, respectively (36). Osawa et al. show that acid sphingomyelinase (SMPD1) and ceramide levels are increased in metastatic liver tumors of colon cancer (37). Corcoran et al. demonstrate that neutral SMPD3 mRNA levels are increased in several tumor tissues when compared with their matching normal tissues (38). Ceramide galactosyltransferase (UGT8) showed lower expression in tumor tissue, but there is yet little information regarding its impact on cancer development. UGT8 encodes an endoplasmic reticulum-localized enzyme responsible for synthesis of galactosylceramide (GalCer) from ceramide (39). Altogether, the significant differences in the expression of CerS2, CerS6, DEGS2, SMPD1, and UGT8 sphingolipid genes in tumor tissue go hand in hand with elevation of ceramide levels (Figure 4). Ceramide is a well-established growth-inhibitory molecule, and up-regulation of growth-inhibitory molecules in human malignancies is not without precedence. Tumor necrosis factor-related apoptosis-inducing ligand is up-regulated in colon cancer, and this increase is associated with higher-grade tumors and a poorer prognosis (40). It is more plausible that up-regulation of specific sphingolipid enzyme mRNA expression in tumors could be a positive compensatory response by the cell as an attempt to increase ceramide production (Figure 5).
Figure 5. CLN3 and sphingolipid signaling pathway interactions analyzed using Pathway Studio. Pathway Studio analysis was used to create a network of biologically relevant genes involved in sphingolipid metabolism and CLN3 for comparisons in normal vs. tumor samples. The position of the node represents the subcellular localization of the gene product. Lines represent type of relations that were automatically extracted from the literature. A total of five genes were represented in the network, with a number of focus genes with functions relating to sphingolipid metabolism.
Breast tumorigenesis is a multistep process going from benign and atypical hyperproliferation, to in situ carcinoma, invasive carcinomas, and culminates in metastatic disease (41). The development and progression of breast cancer is a complex process attributable to the interaction of many genetic, epigenetic, and environmental factors. Altered gene expression profiles may drive disease progression (42). Breast cancer-overexpressed gene 1 (BCOX1) mRNA transcripts are detected in breast cancer tissues, and also, albeit at lower levels, in the corresponding non-tumor breast tissues (43). Hence, it is possible that CLN3 may also be overexpressed in non-tumor tissue surrounding the tumor. Discrepancy between CLN3 mRNA expression in non-tumor tissue surrounding the tumor and non-tumor tissue from reduction mammoplasties was calculated using the concordance correlation coefficient. There was poor concordance between non-tumor tissue surrounding the tumor and non-tumor tissue from reduction mammoplasties (κ = 0.115) indicating that CLN3 gene expression in “morphologically” normal tissue derived from breast cancer patients is different from that of healthy individuals undergoing breast reduction surgery. Non-tumor breast tissue from cancer patients, although normal at the clinical pathological level, is diseased at the molecular level. This finding carries important clinical consequences. After surgical removal of a tumor, there is still a high risk for tumor to develop in the same anatomical area. The new tumor has been traditionally explained by the growth of incompletely resected carcinomas. For cases where the tumor had been completely removed, according to pathology parameters, a genetically altered field at the molecular level remains and may be the cause of new cancer. The presence of a field with molecularly altered cells appears to be a risk factor for cancer. So, our results confirm the concept of field cancerization. In fact, data are widely available that cancer can develop from genetically altered cells in a field that was left behind in the patient after surgical removal of the initial carcinoma (44, 45).
In clinical practice, the elucidation of the association between gene expression profiles and clinicopathological characteristics may aid physicians in selecting patient-suitable treatments. Our findings confirm an association between high expression levels of the CLN3 gene and absence of HER2 expression in breast cancer patients, which increases the possibility of including it as a biomarker in breast cancer diagnostics. Good biomarkers can aid early cancer screening, confirm cancer diagnosis, predict outcome, tailor therapy, and guide future research directions by shedding light on new tumorigenesis pathways. The tools currently available to assess risk of progression of pre-invasive lesions to invasive ones are largely based on epidemiological data and patterns of progression across populations, with little guidance regarding individual risks for tumor progression. Fonsesca et al. show that in pre-invasive breast lesions, such as DCIS, the individual’s risk of progression to IDC is unclear, yet surgery and other therapies seem to decrease the risk of invasive cancer (46). Also, in prostate and colon, pre-invasive lesions are much more common than aggressive cancers, and only 10% or less develop into invasive ones (47). Surgical and other interventions, now considered standard of care, might be excessive in a subset of lesions not destined to progress into aggressive phenotypes. Biomarkers can help select patients requiring intervention, and may allow targeted strategies to be developed for prevention of tumor progression.
A recent study demonstrated that acid ceramidase up-regulation (a ceramide-metabolizing enzyme), is a conserved response to radiation therapy across multiple tumor types and acid ceramidase inhibition can directly improve the clinical response to radiotherapy in vitro and in vivo (48).
In conclusion, the expression of CLN3 is increased in human breast cancer. Moreover, several enzymes from the de novo ceramide synthesis pathway are differentially expressed in breast cancer, implicating ceramide and its upstream regulator, the CLN3 gene, in breast cancer.
CLN3 expression may be an additional useful biomarker and a novel molecular target for cancer drug discovery, the latter achieved via modulation of ceramide pathways.
Conflict of Interest Statement
Patent Methods of Screening for Risk of Proliferative Disease and Methods for the Treatment of Proliferative Disease. Inventors: Boustany et al., met filing requirements of the US Patent and Trademark Office on 1/23/2002 and assigned Serial No. 09/830,045 (US National Phase). Issued, June 6. 2006; US Patent # 60 105 262.
This work was funded by MPP grant to RB MPP320046 and MPP grant to AT MPP320061.
The Supplementary Material for this article can be found online at https://www.frontiersin.org/article/10.3389/fonc.2015.00215
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Keywords: CLN3, breast cancer, HER2, ceramide, sphingolipid signaling
Citation: Makoukji J, Raad M, Genadry K, El-Sitt S, Makhoul NJ, Saad Aldin E, Nohra E, Jabbour M, Sangaralingam A, Chelala C, Habib RH, Boulos F, Tfayli A and Boustany R-M (2015) Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients. Front. Oncol. 5:215. doi: 10.3389/fonc.2015.00215
Received: 20 August 2015; Accepted: 22 September 2015;
Published: 12 October 2015
Edited by:Saleh AlGhamdi, King Saud bin Abdulaziz University For Health Sciences, Saudi Arabia
Reviewed by:Parvin Mehdipour, Tehran University of Medical Sciences, Iran
Abdul-Mohsen Alhejaily, King Fahad Medical City, Saudi Arabia
Copyright: © 2015 Makoukji, Raad, Genadry, El-Sitt, Makhoul, Saad Aldin, Nohra, Jabbour, Sangaralingam, Chelala, Habib, Boulos, Tfayli and Boustany. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rose-Mary Boustany, Neurogenetics Program and Pediatric Neurology, Department of Pediatrics, Adolescent Medicine and Biochemistry, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107 2020, Lebanon, email@example.com | <urn:uuid:6e0515ad-ceab-4ead-9619-1cb2ce64d0dd> | CC-MAIN-2022-33 | https://www.frontiersin.org/articles/10.3389/fonc.2015.00215/full | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.909619 | 11,679 | 1.617188 | 2 |
Statistics Canada recently published a study that revealed the retention rate of Canadian cities for immigrants. The study used the data of immigrants who came to Canada in 2014 through tax file analysis from the 2020 Longitudinal Immigration Database. According to the study, Vancouver, Toronto, and Edmonton had the highest retention rates among Canadian cities. Immigrants who moved to Vancouver and Toronto in 2014 had the highest retention rate at 86% staying in the city in the next five years. Edmonton took third place at around 85%.
Immigration, Refugees and Citizenship Canada (IRCC) published new instructions for foreign workers whose post-graduation work | <urn:uuid:d11ce9e9-0959-41a3-8619-589224b4a1a2> | CC-MAIN-2022-33 | https://lpen.ca/vancouver-toronto-and-edmonton-had-the-highest-retention-rate-for-newcomers/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.973304 | 122 | 1.960938 | 2 |
A building is a part of life for people who live in it. For professionals like Architects and Engineers, it is a passion, for workers and laborers, it’s a source of income and it’s also a source of huge business for so many traders and merchants.
A building is a structure that provides shelter from heat and rain. It can be used for human habitation or for any other purpose.
Why is building important?
Buildings are important because it’s hard to sustain and perform different activities without them. Our work is not just dependent on the skill that we possess, it is also dependent on the tools and environment that a well-designed building serves. You can imagine how dangerous it would be to store hazardous materials, perform lab activities, manufacture different goods without buildings.
What should you know to construct a building?
Well, there are different subjects that are useful while dealing with a construction project like:
- Building designing or planning
- Building drawing
- Building materials
- Building construction
- Interior designing
- Structural engineering
- Construction management
- …. (And much more)
Generally, it is difficult for an individual to deal with all those subjects. Hence, different professionals and workers take up different responsibilities in a construction project. They include:
- Engineers – Civil, Mechanical, and Electrical
- Quantity surveyors
- Construction managers
- Construction estimators
- Interior designers
- Site supervisors
- And more.
What is interesting about the buildings?
The complete procedure of creating buildings is very interesting. Unlike any other thing, buildings are constructed or manufactured at the site. You go through various challenges from time to time and also work hard to create a comfortable and strong building. It’s hard; It’s risky but, the results and praise that will be received are highly satisfying. And more than everything every building has its own stories that will remain throughout its lifetime.
How is the science of building construction evolving from ancient times?
Buildings are not from the last decade, not from the last century and not even the last millennia but, they are there from centuries
The buildings that you see today are way different from the buildings that were built until the 19th century. The early humans took shelter under rocks, huts and then, small dwellings were built using mud bricks, which was then followed with a timely improvement in tools and materials, however, Reinforced concrete buildings were not constructed until it was discovered in the 19th century.
After the advent of RCC design, there are continuous improvements taking place in the industry. So, there is always a need to learn something about Buildings and Building studies is the place you have to look for to fulfill it. | <urn:uuid:e197d5ef-cbf2-40c6-bb7c-71206bacd392> | CC-MAIN-2022-33 | https://www.blog.buildingstudies.com/building-construction-industry/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.968761 | 590 | 2.703125 | 3 |
As a senior practitioner of the Neo-Coptic Style as taught by Isaac Fanous, I receive regular enquiries from people seeking advice and/or tuition in this particular style of iconography. All are disappointed and perplexed as to why it should be so difficult, if not impossible, to find a decent course on the subject, while Byzantine icon courses are so plentiful, some even with excellent masters.
There is an increasing number of Coptic youths eager to study and practice iconography. They lament the nearly total lack of information on the subject, leaving them with no choice but to go it alone using models and a plethora of techniques found online, or else join the nearest Byzantine course. What they do not realise however, is that they will not be able to switch from one style to the other, from one tradition to the other, when they feel like it. Although related through faith and history, the Byzantine and Coptic iconographic traditions are very different from each other, like the languages or spices of different cultures. Yet, there is generally no other choice available to them in most cases. Even if they attend a 5 or 10 day course, they will learn nothing of substance in such a short time. In addition, personal practice is of the essence and a rigorous regimen needs to be implemented under supervision if any progress is to occur. Still technique is one thing, but theory is another and the latter is arguably as important if not more important than the former. But the vast majority is mainly interested in learning painting technique, the know-how rather than the know-what or know-why. These three aspects of knowledge (discipline), the know-what, know-how and know-why, perfectly complement each other like three facets of the same stone, so to speak. But if one of the three is subtracted from the equation, it immediately creates a problem – for example knowing what to do, but not how to do it or why, or any other permutation, will lead to the same negative outcome. That is why appropriate education is so important to hold the three in balance for optimum results.
In the West, those who are specifically interested in studying Neo-Coptic iconography will not find anything remotely related to it on any of the available art college courses. Entrenched in post-modern secularism and political correctness, Western art colleges do not consider Christian art as a living tradition, let alone worthy of a dedicated course.
So acute is the need that I once considered starting an online course, perhaps through an online Coptic academic platform. It seemed like an excellent idea at first. But after careful consideration, I concluded that the online format failed to take into account that iconography is a studio-based practice and requires an analogue studio/building where students can try their hand at gesso making, drawing, using pigments, as well as attend lectures and discussions on its various aspects. These basic practical studio activities are unfortunately not possible in a virtual classroom.
The Department of Art & Archaeology at the Institute of Coptic Studies Cairo, headed by Isaac Fanous was the epicentre of Coptic art for 50 years and provided precisely what my enquirers desperately seek, i.e. a place to study the liturgical arts of the Coptic Orthodox Church, both theory and practice. I was greatly fortunate to study there for 8 years in the 1980s and will never forget the powerful and highly inspiring atmosphere pervading the place. The studio was a hive of activity: students were busy helping in the preparation of large icon panels, gilding, laying down the proplasmos (underpainting) after Dr Isaac had completed the designs. Everything was done under his meticulous scrutiny, as there was no room for mistakes. Work went on 6 days a week. Many of Dr Isaac’s icons now considered heirloom master pieces of contemporary Coptic art, were painted during this very prolific period of the 1980s (See Fanous Claremont Coptic Encyclopaedia).
This is the ideal way to study iconography, getting hands on experience in a busy studio and most especially under a great master. Of course it is not the only way to study it, but it is by far the most preferable, as well as the most traditional/ancient. The way things are currently shaping up, it would seem unlikely that this kind of environment could be replicated in the contemporary Coptic context. There are however some activities still taking place in the now modernised art department at the Institute of Coptic Studies. Yet even with the cosmetic facelift, it is only a pale shadow of what it was in its heyday. The fact that it is no longer the epicentre of Coptic iconography is not meant as a criticism or the fault of any individual, but a mere observation by simple before/after comparison. Taking a cursory look at the art of the recently completed St Mark’s Cathedral is enough for the informed eye to realise that, as the expression goes, things ain’t what they used to be.
In Australia, H.G. Bishop Suriel, Coptic Bishop of Melbourne, is still until this day the only Coptic Bishop in modern times to have included iconography as an integral part of a Coptic diocese. An author and scholar in his own right, Bishop Suriel is a strong believer in the preservation of tradition through education. Under this ethos he established St Athanasius Coptic Theological College (SAC) in the early 2000s, to provide “quality theological education in the Orthodox Alexandrian tradition” according to the College’s website. SAC has a physical campus and its courses have been accredited by the University of Divinity, Australia, since 2011. Bishop Suriel took the unique initiative of including Coptic iconography as part of the curriculum. The course is led by my colleague and friend Ashraf Gerges Fayek, whom I first met in Cairo while we were both students of Isaac Fanous during the 1980s. To avoid the kind of situation befalling the vast majority of Coptic churches around the world with regards to bad and/or heterodox iconography, Bishop Suriel appointed Ashraf as his head iconographer and made him responsible for all matters regarding iconography in the diocese, thus eliminating the problem in one master stroke. This is the very best way to insure the survival and further development of Tradition and H.G. Bishop Suriel should be commended for his far sighted vision and understanding of the issues at stake. Such initiative however, relies solely on whether the iconographer in charge is appropriately educated, qualified and experienced and more importantly, whether he/she, like Ashraf, follows the precepts and canon established by our teacher Isaac Fanous and not their own personal brand. How many of us are left today still practicing and/or teaching the Fanoussian canon? I’d love to hear from them.
There was a glimmer of hope in California during the mid 1990s when something concrete and far reaching could have been done with regards to iconography. At the time my wife, Monica, was doing her PhD research on Coptic heritage and the legacy of Isaac Fanous at the School of Oriental and African Studies (SOAS) in London. Her planned field trip to Egypt had been cancelled because of Gulf War 1 and she had been sent to Los Angeles instead, to look at the Coptic presence there. As it turned out, Isaac Fanous had been in LA for a while, in the middle of completing what has now become his most famous work at Holy Virgin Mary Coptic Orthodox Church in Highland Park. We stayed with him in the old wooden cottage provided by the church until he went back to Cairo, then continued our work in California for another 4 years on and off.
It was during this time that the diocese of Southern California and Hawaii was created and H.E. Metropolitan Serapion (then H.G. Bishop Serapion) was enthroned as its bishop. We were already acquainted with H.E. Serapion, as he had kindly given Monica some assistance while working on her MA project in Old Cairo in the 80s, when he was Bishop of Social Affairs . It was Fr. Antonios Henein of blessed memory, head priest at Holy Virgin LA and an unconditional supporter of Isaac Fanous and the Neo-Coptic movement (see Claremont Encyclopaedia, Isaac Fanous), who organised some meetings with Bishop Serapion, Monica, Fr Bishoy Brownfield and myself with a view to creating a studio of iconography in the diocese that would include an educational programme as well as the possibility of training apprentices, similar to the above described model implemented by H.G. Bishop Suriel in the Diocese of Melbourne. Let us further bear in mind that these were the mid 1990s and that Isaac Fanous was still very much active and would remain so for the last 10 years of his life, mostly in Southern California. He would have been fully involved in the project from the start, since this was one of his dearest wishes and the subject of many a conversation over the years. Since California has numerous large purpose-built churches as well as remodelled ones, it would have created the perfect ecology for iconography to flourish. Unfortunately, no steps were taken, the project was forgotten and the status quo remained. This had the unintended consequence of turning the Diocese of Southern California into a museum of Isaac Fanous’ work, instead of a living, thriving centre of Coptic iconography. By the same token SoCal became fertile ground for the kind of “innovations” described in a previous post here https://copticiconography.com/2020/01/23/coptic-iconography-in-the-age-of-social-media/
When speaking of education, let us note that iconography is still largely considered a hobby in the Coptic Church or an extra-mural activity. According to this way of thinking, it follows that one is not required to pursue any particular course of study, hold any degree or qualifications in order to practice in the church. Consequently there is no standard of excellence to strive towards as every/anyone is allowed to do as they please and more or less how they please. As discussed elsewhere in this blog, the post-Fanous era is in many ways much worse than the pre-Fanous period because of the unbridled proliferation of uninformed/misinformed iconography through social media among other things. This is not to say that there is no talent in the Coptic church, far from it. The problem is that whatever talent there is is not fostered, channelled or educated to achieve its best potential and the high level of excellence iconography demands. Rather it is left with neither discipline nor discipleship which are the very building blocks of a living artistic tradition and the main vehicle of transmission of tradition. Whether this is by design or by default, I cannot say, but the results are certainly plain to see…
N.B. this post is mainly concerned with the basic study of iconography, not graduate and post-graduate studies. | <urn:uuid:8ac625c6-e85b-4bbb-87d4-71bd41128c29> | CC-MAIN-2022-33 | https://copticiconography.com/author/stefanous/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.974234 | 2,299 | 1.703125 | 2 |
What types of businesses have you seen attacked in your market?
Sheila Pancholi, Partner – RSM UK
The world is moving on quickly. Smart devices and social media are intertwined, leaving users, homes, healthcare, financial, manufacturing and other industries vulnerable, hackable and easy targets to be taken down and/or held for ransom. The numbers are getting too large to ignore, and the steps manufacturers, companies, and consumers are taking to secure us all are too slow and too few. Many of these companies are themselves suffering from cybersecurity budget cuts along with skilled security staff shortages.
Phishing, whaling (both types of social engineering) and ransomware still continue to lead as the most popular and successful methods used to gain access to networks, systems and data or gain confidential information. Phishing and whaling techniques can often be deployed on the phone or via texts, they don’t always occur via an email scam.
The UK was the biggest target for ransomware attacks, over the first half of 2019, with the number rising 195% from prior year. In 2019 the US and the UK were still the most attacked nations, positioned first and second respectively.
Darren Booth, Partner - RSM Australia
The weakest link still seems to be through employees and getting them to open malicious emails or click on malicious links. The problem is that many organisations still have legacy systems that are not being appropriately updated and supported, giving attackers an easier attack vector to get a foothold in the organisation once they gain access via an unsuspecting employee.
Gregor Strobl, Partner – RSM Germany
Cyber-attacks have risen to an even higher level of sophistication and hacker groups are using long term tactics and different levels of attack approaches to gain access to the IT infrastructure. This could be the usage of a so-called “guerrilla tactic” where the group would perform a “shadow attack” in order to create chaos and confusion while running around and starting the actual attack.
In addition, it is the pure number of growing attacks that is also proving a greater risk to all companies. The reason for this increase is the high volume of Emotet malware campaigns globally, but also in Germany. According to BSI, Emotet is one of today's most dangerous and widespread malwares. Security researchers first identified the Emotet Virus in 2014. Originally Emotet was designed as a banking malware that attempted to sneak onto your computer and steal sensitive and private information (e.g. by using infected Word Documents). Later versions of the Emotet Virus saw the addition of spamming and malware delivery services. In addition, Emotet is particularly dangerous because it allows the hacker to “load” further malware to the infected infrastructure.
Hope, Kajnalka & Nagy, Lucy, 2019, The Emotet killchain. [Online]. [Accessed 5 March 2020]. Available from: https://news.sophos.com/en-us/2019/03/05/emotet-101-stage-3-the-emotet-executable/ | <urn:uuid:ee3b9ed0-6249-485e-bf75-5d62dae858eb> | CC-MAIN-2022-33 | https://www.rsm.global/insights/cyber-security/cybercriminal-tactics | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.943135 | 637 | 1.953125 | 2 |
Only about one in 10 Americans would feel comfortable talking about how much they make at a dinner party. In fact, people would rather discuss just about any other hot-button topic: romance, religion, medical conditions or even politics, according to a recent poll by Lexington Law of over 3,000 U.S. adults. And about two-thirds of those polled said they'd avoid talking about any of these sensitive topics at all.
That attitude carries over into more private settings, too. Money, especially, is still a taboo subject: Only one in five people say they would ask a friend their salary, according to the survey.
Norms are changing, though. The survey found that 25 percent of younger Americans (age 18-24) said they did feel comfortable asking their friends about their incomes. That's compared to just 9 percent of Americans over the age of 65.
Millennials are also far more willing to discuss their finances with their partners than older generations. And experts say that's helping make them happier.
A full three-fourths of millennials in committed relationships say they talk about money on a weekly basis, according to a new survey from TD Bank of over 1,700 U.S. adults. That's about 9 percentage points higher than the share of Gen X couples, and an astounding 31 percentage points higher than the share of baby boomer couples, who say they have weekly discussions about their finances.
"We're in a better place than we used to be because younger couples are more willing and open to talk about their money — and to address it directly, right out of the gate," Dr. Jane Greer, a psychotherapist and relationship expert, told CNBC Make It.
Like this story? Subscribe to CNBC Make It on YouTube! | <urn:uuid:5bc7558c-c023-486f-ba60-36a60136c027> | CC-MAIN-2022-33 | https://www.cnbc.com/2018/08/08/americans-would-rather-talk-about-anything-than-income.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573744.90/warc/CC-MAIN-20220819161440-20220819191440-00472.warc.gz | en | 0.974296 | 361 | 2.0625 | 2 |
If you have been invited to a Catholic funeral, you may not be sure whether you want to attend or not if you have never been to one before. You may not be sure what to expect and that can keep you from attending. Catholic funerals can really help the healing process after a loss, however, so you do want to consider attending. To help you know what you can expect, there are some things that directors of funeral homes in Hamilton, OH want you to remember.
There are three distinct parts to the Catholic funeral. The first part is the vigil, or the wake, where people will recite the rosary. It takes place at the funeral home, offering everyone a chance to say goodbye to the person they lost. The casket is usually there, and it can be open or closed. After the vigil service, there is the funeral mass. It will take place in the same church where the person used to take the sacraments. A procession will bring in the casket, which the priest will bless, and there will be blessings and the offering of bread and wine. After the recessional, there will be the graveside committal, where the body is laid to rest in the cemetery.
Catholic funerals are very somber occasions, so do wear something that is dark and appropriate. The mood of the service will be serious, especially since it can focus on the passing of the person along with the resurrection of Christ. Some people choose to have a service after the burial and when they have already made all of the necessary arrangements. You want to follow the lead of the other people around you, and while you do not have to kneel if you do not want to when called to do so, you do want to sit down and be otherwise respectful
Another thing that you want to remember is that the most common sympathy gift people give loved ones at a Catholic service is cards. If you want to send flowers, you want to do so through a florist, and be sure to also include a message. You can also choose to make a donation to the family to help with funerary services. If the person who died wanted a donation made to a particular charity, the service program or the obituary will mention it.
These are some of the things you want to remember when attending a Catholic funeral. As with any kind of funeral, you want to be very respectful and offer your condolences in a meaningful way. The Catholic service tends to be a bit longer than other types of funeral services, so do keep that in mind. If you want to know more about Catholic services or if you want to get started planning one, you can reach out to a Hamilton, OH funeral home like us. We are ready to answer all of the questions you have about this and much more. Call us right now or visit us today at one of our locations to ask any questions you may have. | <urn:uuid:c932478e-8e36-4ee7-a88c-16cf0e2614cd> | CC-MAIN-2022-33 | https://www.paulyoungfuneralhome.com/blog-posts/8006/what-to-know-about-catholic-funerals | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.969624 | 590 | 1.515625 | 2 |
Wheat crop in Argentina revised upward fourth consecutive time
Wheat production in Argentina in 2021/22 was revised upward for the fourth time over the past month by the Buenos Aires Grains Exchange, Agweb.com reports.
Farmers are expected to harvest 21.8 mln t of wheat. The increases in the estimates were driven by higher than previously foreseen wheat yields.
"As the new crop progressed, the yield of wheat harvested in the southeast of Buenos Aires increased. It is a key region due to its yield potential and share in the total planted area," the Buenos Aires Grains Exchange says in a statement.
Wheat new crop campaign in Argentina is close to its completion.
Wheat production in Ukraine in 2021/22 reached 32.44 mln t, the average yield made up 4.59 t/ha.
Wheat export from Ukraine in 2021/22 was limited to 25.3 mln t. The Memorandum of Understanding was signed by the Agrarian Ministry and grain market participants. The government also considers milling wheat export from the country. The decision is reported to be taken in January. | <urn:uuid:a1e65f11-5515-4344-b8b7-c0d107ed5fc8> | CC-MAIN-2022-33 | https://latifundist.com/en/novosti/57951-visoki-prognozi-urozhayu-pshenitsi-v-argentini-vchetverte-pidnyali-tsini-na-birzhah | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.963462 | 231 | 2.0625 | 2 |
Community-Curated Exhibition Prioritizes Pueblo Indian Knowledge and Experience
Organized by the School for Advanced Research and the Vilcek Foundation, the exhibition debuts July 31, 2022, on Tewa Indian lands at the Museum of Indian Arts & Culture in Santa Fe before traveling nationally.
Museum of Indian Arts & Culture, Santa Fe, 2022 • The Metropolitan Museum of Art and the Vilcek Foundation, New York, 2023 • The Museum of Fine Arts, Houston, 2024 • Saint Louis Art Museum, 2025
But the launch of a unique traveling exhibition featuring over 100 historic and contemporary works in clay offers a visionary understanding of Pueblo pots as vessels of community-based knowledge and personal experience.
Originating in the cradle of the Indigenous Southwest, Grounded in Clay: The Spirit of Pueblo Pottery is a rare exhibition curated by the Native American communities it represents. The project gives authority and voice to the Pueblo Pottery Collective, a group of over 60 individual members of 21 tribal communities who selected and wrote about artistically or culturally distinctive pots from two significant Pueblo pottery collections—the Indian Arts Research Center of the School for Advanced Research (SAR) in Santa Fe and the Vilcek Foundation of New York.
Organized by SAR and the Vilcek Foundation, Grounded in Clay debuts July 31, 2022, on unceded Tewa Indian lands at the Museum of Indian Arts and Culture in Santa Fe before traveling nationally in 2023. The exhibition celebrates the 100th anniversary of the creation of SAR’s Indian Arts Research Center’s pottery collection in 1922. As SAR’s first-ever exhibition, it also marks the institution’s 13-year efforts to bridge the cultural needs and knowledge of Native communities with its public education mission.
“Grounded in Clay is part of our public education mission which, in this case, enables the public to experience pottery through the eyes of Native peoples,” says SAR President Michael F. Brown.
Indian Arts Research Center Director Elysia Poon adds, “Pottery permeates the lives of Pueblo peoples. For many, it is impossible to divorce the pieces from the people.”
San Ildefonso jar with lid, ca. 1900-1910
Clay and paint
20 11/16″ x 16″
Cochiti mono figurine, ca. 1900
Clay and paint
13 3/4″ x 6 3/4″ x 6 1/8″
Santo Domingo water jar, ca. 1905-1915
Clay and paint
11 1/2″ x 10 3/4″
Grounded in Clay shifts traditional exhibition curation models, combining individual voices from Native communities where pots have been made and used for millennia into a uniquely Indigenous group narrative. The approach illuminates the complexities of Pueblo history and contemporary life through the curators’ lived experiences, redefining concepts of Native art, history, and beauty from within, confronting academically imposed narratives about Native life, and challenging stereotypes about Native peoples.
“The Pueblos are not a monolith,” says Poon. “Within each community, there are both individual and shared experiences. In many cases, the curators picked pots that weren’t even from their own community. It resulted in a much more complex and rich mixture than we imagined.”
Dating from pre-contact to the present day, the featured pots connect and contrast the lives of Puebloans in communities spanning from New Mexico’s 19 Río Grande Pueblos to the West Texas community of Ysleta del Sur to the Hopi tribe of Arizona. Curators of diverse ages, backgrounds, and professions selected and wrote about one or more works, demonstrating their intimacy with pottery at home and in the greater Pueblo world.
Unlike exhibitions guided by Eurocentric timelines and Western concepts of art and history, Grounded in Clay’s focus on personal and community meaning emerges as a conversation expressed in prose, poetry, and the visual language of pottery. The curators’ firsthand knowledge of pots and potters, family rituals, traditional materials, and daily use grounds viewers in a powerful sense of people and place. At the same time, a thread of ancestral memory connects individual pots to the pride, pain, and living legacy of Pueblo peoples. For example:
- Museum curator Tony Chavarria writes of a ca. 1900 stone-polished blackware olla from his home pueblo of Kha’p’o Owingeh/Santa Clara whose shape sparks a memory of his grandmother’s favorite vintage dress: “I see the flared collar and high neck in this jar. I see my grandma in the beauty from the earth.”
- Haak’u/Acoma Pueblo Governor Brian Vallo praises the skills of the unidentified maker of an extraordinary ca. 1880 Acoma polychrome storage jar: “The master potter had the skill not only to form a jar this size, but to carefully execute other steps in its creation, including a successful outdoor firing. The designs on both the neck and body are classic Acoma pottery patterns depicting clouds, rain, and corn fields. This jar sings loudly to me through its design and its lived experience at Acoma.”
- For artist Kathleen Wall (Walatowa/Jemez), an aunt’s ca. 1982 Nativity set helps reconcile the religious persecution of the past: “Although, Pueblo religion and culture have a long history of concessions and acceptance in order to appease Catholic religion, over the centuries, this has transformed into a beautiful syncretism and celebration of faith for New Mexico Pueblo people.”
- Finally, journalist Tara Gatewood (Shirr-whip Tui/Isleta, Diné) muses on the transformative power of a ca. 1100-1300 Mogollon jar: “To you reading this right now, the viewer, the visitor, the ancestor: Who were you when you stepped to this pot, who are you now?”
Hopi canteen, ca. 1880
13″ x 12″
Ladle, 1050-1300 / Mesa Verde mug, ca. 1150-1300
Clay and paint
Ladle 2 1/4″ x 11 7/8″ x 5 1/2″ / mug 4 1/2″ x 4″
IAF.2400 / IAF.2360
Jeralyn Lujan Lucero, Taos Pueblo
Figure of woman with bowl, 1995
Micaceous clay and turquoise
Figure 10 1/16″ x 9 13/16″ x 9 7/16″; bowl 3 1/4″ x 4 1/2″
BUILDING EQUITABLE RELATIONSHIPS
Grounded in Clay is part of a broader SAR initiative to build equity between museums and Native communities. As an international research institution supporting scholarship in social sciences and the humanities, SAR has engaged with Native communities through the Indian Arts Research Center collections since 1922. In 2008, the center embarked on a bold new approach to collections stewardship.
“As caretakers of these collections, we asked ourselves who we are accountable to,” Poon recalls. The question led SAR to shift how it cares for, displays, and interprets its pottery and other tribal collections—in collaboration with, and guidance from, Native communities.
SAR’s efforts and those of other like-minded institutions inspired dialogue with Native and non-Native museum professionals, cultural leaders, and artists. Over three years beginning in 2012, the group developed SAR’s “Guidelines for Collaboration,” a set of principles for building welcoming and successful Native collaborations in collections management, exhibitions, education, and public programs.
“SAR is changing the nature of artistic stewardship,” says SAR President Brown. “As standards change and ideas change, the guidelines change. They are a work in progress in the best possible way.”
SAR’s collaborative approach extends to all aspects of Grounded in Clay, including a robust calendar of educational outreach, exhibitions and collections tours, and other public and private programs on the SAR campus, at the exhibition site on Museum Hill, and online. As Pueblo voices resonate in O’gah’poh geh Owingeh/Santa Fe and points beyond, the public will experience pottery as a dynamic, ever-evolving form of American art.
“This show challenges the concept of historic pottery as relegated to the past,” Poon says. “A bulk of the pieces were made in the 20th century, contemporary with the works of Kandinsky or Warhol. As long as they exist within the living memory of Native peoples, their stories are vibrant and alive.”
Grounded in Clay has partnered with the Museum of Indian Arts & Culture for its debut in the Southwest before traveling to The Metropolitan Museum of Art and the Vilcek Foundation in New York; The Museum of Fine Arts, Houston; and the Saint Louis Art Museum. The schedule of presenting partners for this exhibit is:
- July 31, 2022–May 29, 2023, Museum of Indian Arts & Culture, Santa Fe
- July 13, 2023–June 4, 2024, The Metropolitan Museum of Art and the Vilcek Foundation, New York
- October 27, 2024–January 19, 2025, The Museum of Fine Arts, Houston
- March 9–June 1, 2025, Saint Louis Art Museum | <urn:uuid:743ed330-4ef8-449d-8c8c-46c961788d61> | CC-MAIN-2022-33 | https://sarweb.org/iarc/grounded-in-clay/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.926084 | 2,064 | 2.140625 | 2 |
Actions or behavior is a reflection of the heart and mind. Look in the mirror at yourself. Your life, actions, believes, thoughts! Look deep into your heart & spirit. What do you see? What gets in your heart comes out in your life! What comes out of the mouth & behavior is a window of one’s heart. What one says about another person says more about them than the person they are speaking about!
When you squeeze a lemon…you get lemon juice!
When you squeeze a grape…you get grape juice!
When you squeeze a person…
What comes out is whats inside!
Jesus said, “But what comes out of the mouth proceeds from the heart, this defiles a person. For out of the heart come evil thoughts, murder, adultery, sexual immorality, theft, false witness, slander. These are what defile a person.” Matthew 15:16-20
“What comes out of a person is what defiles him. For from within, out of the heart of man, come evil thoughts, sexual immorality, theft, murder, adultery, coveting, wickedness, deceit, sensuality, envy, slander, pride, foolishness. All these evil things come from within, and they defile a person.” Mark 8:18-23
“Search me oh God and know my heart. Try me and know my thoughts. See if there be any wicked way in me and lead me in the way everlasting.” Psalm 139:23-24
“Create in me a clean (pure) heart, oh God.” Psalm51:10
“Therefore if anyone is in Christ, he is a new creature (creation); old things passed away; behold, all things have become new.” 2 Cor. 5:17
“If we walk in the light, as He is in the light, we have fellowship with one another, and the Blood of Jesus His Son cleanses us from all sin.
If we say we have no sin, we deceive ourselves, and the truth is not in us. If we confess our sins, he is faithful and just to forgive us our sins and to cleanse us from all unrighteousness.” 1 John 1:7-9
“Believe in the Lord Jesus, and you will be saved.” Acts16:31
What can wash away my sins nothing but the Blood of Jesus! Jesus came to seek and to save the lost like me and you.
Jesus, the Cross and His Holy Blood! Jesus came forth from the grave and ever lives to make intersession for us. Glory! Have a talk with Jesus Now. The only hope to be saved.
Pilgrim followers of Jesus, Arthur and Denise Blessitt, Luke 18:1 | <urn:uuid:73105358-6603-43d0-880b-a6b85b3ad020> | CC-MAIN-2022-33 | https://blessitt.com/actions-or-behavior-is-a-reflection-of-the-heart-and-mind/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.92832 | 589 | 1.539063 | 2 |
An Overview of Cell Antivirus
Mobile anti-virus is an important device for any end user. Most mobile phones are unprotected, making them a prime target designed for attackers. These attacks frequently require rising privileges to work, although a portable antivirus method can detect and wedge these dangers regardless of the technique used. This post will provide an review of mobile anti virus and what to find when choosing one particular. Hopefully, the information provided will let you make an knowledgeable decision think about a mobile phone antivirus to your device.
The malware harm happens in three stages. First, this infects the host, consequently reaches the goal, avast call blocker for ios and then distributes to other systems. Malware typically uses the time of the mobile phone, including output equipment, email addresses, and address book. Additionally, it exploits the trust of acquaintances to spread. Thus, a portable antivirus must prevent the propagate of this adware and spyware. These moves can cause a wide range of problems for the mobile individual, so you should consider precautions.
A mobile ant-virus will help you look after your smart phone and prevent sensitive information from falling into the wrong hands. Depending on the sort of software that you just choose, you may well be able to lock your phone or perhaps block specific numbers, and block websites and applications that could possibly include malware. Several mobile anti virus apps have parental control buttons. These can prevent children from viewing content material they really should not. These cell security applications will also force away Wi-Fi strategies. | <urn:uuid:86052672-4d1d-4ec4-bb63-3bd621722b9e> | CC-MAIN-2022-33 | https://www.fundacionpsiformacion.org/an-overview-of-cell-antivirus/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.921856 | 313 | 2.421875 | 2 |
What is Geothermal Energy?
The earth is hot and brimming with energy. If you’ve ever witnessed the spectacle of erupting volcano, visited the Geysers situated at Yellow Stone national park in the United States, or sat in a geothermal hot spring, you’ve already come across geothermal energy. The more you go underneath the earth’s surface, the hotter it becomes. The earth’s crust is composed of hot rocks and water. Below the earth’s crust exists a layer of molten hot rock known as magma, which is considered to as hot as the surface of the sun. This heat found inside the earth is called geothermal energy.
By definition, geothermal energy is the energy stored as heat underneath the surface of the earth. Its net potential is limitless with regard to humans, and its energy is the same as the sun. Geothermal heat and water have been utilized for centuries. The Native Americans, Chinese and Romans utilized hot geothermal springs for cooking, bathing, and therapeutic applications.
In the modern day, geothermal energy is utilized in numerous applications, for example, heating, systems that provide hot water or steam to a wide range of units, along with heating and cooling of private and commercial buildings such as residential homes, offices, and shops by utilizing geothermal heat pumps. Also, geothermal energy has industrial potential to grow plants in greenhouses, heating water at fish farms, drying crops and many other industrial processes.
This enormous energy is also being harnessed to generate electricity through geothermal power plants. Using the modern day technology, humans are able to pinpoint the location of geothermal resource, drill wells a few kilometers deep and extract the hot water below.
Advantages of Geothermal Energy
Unlike fossil fuel plants, geothermal energy plants do not involve any form of combustion. This means they give off significantly few amounts of greenhouse gasses. Binary geothermal power plants, which are the most common in the world together, along with their flash binary counterparts emit close to zero greenhouse gas. Even dry steam geothermal power plants are more eco-friendly than fossil-fuel based power plants.
Geothermal heat pumps used for heating and cooling buildings are also ranked among the most efficient cooling and heating systems obtainable today. This is due to their relatively low electricity requirement. Their use massively minimizes emissions coming from power production. On top of those, geothermal energy boasts of small land-use footprint. In fact, it ranks among the smallest per kilowatt of all electricity production technology including nuclear, coal and other renewable energies.
2.Renewable power source
Geothermal power generation injects a sense of reliability to the national power system. Geothermal energy can be generated as a base-load renewable energy resource, which means production occurs 24/7 despite changing weather patterns, thereby offering an exceptionally reliable and constant source of green energy. As a base-load source of power, geothermal energy is primed to take the place of coal in the traditional utility system.
Geothermal energy is also flexible enough to bridge the gap created by the intermittent renewable energy resources like solar and wind. Since geothermal energy production can be easily increased or decreased depending on current demand, it can be utilized to maintain the integrity of the national power grid, hence, ramping up the overall efficiency of the whole electricity generation system, while at the same time offering reliable and clean energy.
Geothermal energy is also highly scalable. This means small power plants (a few tens of KWS) are able to be economically set up and tailored to applications existing in communities.
3.Creates new jobs
Initiation of geothermal projects spurs the economy of rural areas, which are typically characterized by unemployment, thereby creating new jobs. A good example is the plan initiated in 2012 to set up a new power complex in Imperial Valley, California, a state that was experiencing the lowest unemployment rates in the United States. The planned investment involved injection of about $1 billion, which was projected to bolster the economy of the area. The project materialized and took about 4 years to complete.
On average, 323 workers were involved in the project. When the project was up and running, more than 57 jobs were created in the fields of maintenance, operations, engineering, and administration. This project underscores the sheer size of employment opportunities that a single geothermal power plant can create.
The earth’s internal heat is available around the world. The only limitation is the capability to extract the energy. However, with advances in technology (geothermal heat pumps), individuals have been able to harvest this hot water from the reservoir below the earth to heat homes and businesses. Even so, advance resources are needed for converting this heat into electricity at individual level. With the rapid growth of technology, economic systems will be developed to convert this abundant heat into electricity by individuals in the near future.
5.Significant savings on your utility bills
Installation of geothermal energy systems requires high upfront capital investments compared to traditional systems due to the buried loop system. Some homeowners shy away from installing geothermal systems due to this initial cost, but fail to view the bigger picture. When the geothermal system is fully operational, you’ll witness significant reduction in your utility bill (by up to 50%), plus they require low maintenance costs. Most institutions tie the upfront cost of installing a geothermal system to your monthly mortgage remittances or other interest financing alternatives. The savings accrued from your utility bills could be enough to offset the increase in your loan payment, offering you additional cash flow.
Generally, geothermal systems utilize small quantities of electricity to transmit heat to and from the ground to your house. Averagely, it’s able to generate 4 units of energy per every unit of electricity utilized to drive the system. Even the top notch traditional systems convey less than 1 unit for every unit they consume. These days you can use online calculators to see the exact amount you can save per month by installing a geothermal energy system.
6.Promotes national unity
Geothermal energy is entirely available and produced locally, and it doesn’t need fossil fuels to operate. This means it can comfortably minimize over-dependence on fossil fuel sources of energy. Additionally, since electricity is increasingly becoming utilized in the transportation sector, it’s able to outrightly take the place of imported oil. Direct utilization of geothermal heat for specific industrial, commercial and agricultural purposes offers impeccable option to other thermal sources of energy such as oil, electricity, natural gas, and propane.
By ramping up the availability of local fuels around the world, geothermal energy is able to boost our capability to take charge of our economic future and bolster our national security, while at the same time preserving the available natural gas and oil resources for the most important uses, for instance, pharmaceuticals, liquid fuels for transportation and chemical feedstock.
7.No sound pollution
A geothermal system uses exactly the same principles as a freezer or refrigerator. It operates quietly. It’s a good system to maintain a good relationship with your neighbors. Traditional heating and cooling systems produce a lot of noise that can irritate you and your neighbors causing unnecessary disagreements.
8.Free hot water production
As an added advantage, geothermal systems are able to generate some if not all of your hot water at higher efficiencies than conventional techniques. A simple modification is performed in your geothermal system to enable it to deliver hot water that can be stored in your water heater for later use. Also, during the cooling cycle, the heat extracted from the building is sent to the water heater instead of being transferred to the ground. This guarantees you free hot water as long as the geothermal system is functioning.
9.High efficiency coupled with low maintenance
Geothermal heat pumps are characterized by high efficiency. Averagely, they use 25% to 50% electric power for cooling and heating. And the fact that they come with flexible designs, means they can be tailor-made for various situations, needing a much lesser space compared to the traditional systems. Also, because geothermal systems are designed with fewer mobile parts, and these parts are housed in a building, makes their life expectancy significantly high.
These systems are also advantageous since the pipes come along with impressive warranty of up to 25 years, keeping in mind that the system can last for up to 20 years. This is, essentially, a lifetime warranty. Besides geothermal systems having a long lasting attribute, they are utterly user-friendly and convenient. Durability means they require low maintenance, which saves you a lot of extraordinary maintenance costs.
Although geothermal energy doesn’t enjoy the popularity of other renewable resources such as wind and solar, it’s an incredible, renewable and relatively cheap alternative that merits a multitude of support. In fact, governments are releasing reports stating the reasons why citizens should support geothermal energy developments to ensure more individuals are tapping this abundant resource to bridge the electricity gap. | <urn:uuid:9337710f-e47a-44e8-9feb-40e5a42bfb89> | CC-MAIN-2022-33 | https://tiredearth.com/news/advantages-of-geothermal-energy | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.938243 | 1,862 | 3.578125 | 4 |
Healing foot pain – How to Choose Plantar Fasciitis Socks
If you are suffering from plantar fasciitis, you should wear Plantar Fasciitis socks to ease swelling. They stretch the plantar fascia muscle and provide arch support. But they can also cause pain during training. Here are some tips on how to choose the right type of sock for your situation. Here are the benefits of compression socks. Firstly, they help improve circulation, stretch the plantar fascia muscle, and provide arch support.
Compression socks reduce swelling and pain
Compression socks are an excellent way to treat and reduce the symptoms of plantar fasciitis and can be found on Google. These socks are made to apply constant gentle pressure on the affected area and can also provide other massage benefits. Because they are relatively inexpensive, these socks can be an excellent and easy-to-use treatment option. They are most effective when used in combination with other proven treatments for plantar fasciitis. Here are some benefits of wearing compression socks for plantar fasciitis:
Plantar Fasciitis socks help stretch the plantar fascia muscle
Many people have heard of using plantar fasciitis socks and search Amazon for them. Using them in conjunction with a good heel insert is an effective way to prevent and treat the condition. However, not all socks are effective. In addition to helping stretch the plantar fascia muscle, they also aid in reducing pain associated with plantar fasciitis. To find the right pair for you, follow the steps below.
They improve circulation
Compression socks for plantar fasciitis improve circulation and reduce inflammation, which are important in the treatment of this overuse injury. Compression tightens the veins and forces blood to flow in a concentrated spray. Graduated compression socks help support the venous walls and push deoxygenated blood back to the heart, improving circulation. These socks are a great alternative to traditional braces for plantar fasciitis.
Plantar Fasciitis Socks provide arch support
Wearing plantar fasciitis socks provides arch support while walking or standing which many Twitter users suggest help them. A great pair of plantar fasciitis socks will reduce the pain caused by heel pain. Unlike bulky arch support socks, these are comfortable to wear all day long. They are also available in several colors and sizes, and can be worn with almost any type of shoe. Here are some tips for choosing the right plantar fasciitis sock for your needs.
They are available in a variety of lengths
Compression foot sleeves provide relief for heel pain, plantar fasciitis, and other foot ailments. These sleeves stabilize the ankle joint and improve foot circulation. They also help heal edema and heel spurs. Compression foot sleeves are designed to be worn with ordinary socks. Compression foot sleeves are an excellent option for those with flat feet. The material they are made of is breathable and moisture-wicking, and they also help prevent foot sweat and other foot problems.
They are comfortable
A good pair of plantar fasciitis socks should not cause any discomfort. However, some people report that their socks lack arch support. Some may feel too tight at first, and it will take some time to get used to them. These socks should be worn only when you are taking your shoes off. If you are planning to use compression socks with orthotics, consult your pedorthist before making a purchase.
Company Name: Atlecko
Contact Person: Nathan Morgan
Email: Send Email
Address:130 Old Street
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If you own a car or are enthusiastic about vehicles, you are probably familiar with power steering fluid and transmission fluid. At first glance, both of them seem to be quite similar.
Power steering fluid is not the same as transmission fluid. They are made for different purposes and have different properties. Power steering fluid makes it easier for you to turn the steering wheel, while transmission fluid lubricates transmission gears to make the shifting process smoother.
In this article, I will talk more about what separates power steering fluid from transmission fluid, whether they are interchangeable or not, and how often they need to be replaced.
To understand the key differences between power steering fluid and transmission fluid, let’s take a more detailed look at each of them.
Power steering fluid is a form of hydraulic fluid used in the power steering system. This system makes it so that less force is required to turn the steering wheel, especially while the car is at rest or traveling at low speeds.
If you’ve driven in an older car without a power steering system, you can probably tell the difference. It is very noticeable. Fortunately, almost all new vehicles use the power steering system.
The fluid’s role is to act as the hydraulic conduit through which the system can exert force on the two front tires to make turning them easier for the driver. The fluid also has the additional benefit of lubricating all the parts involved in the system, which allows them to function well and last longer.
In terms of physical appearance, power steering fluid is most commonly light red, orange, or pink. It may also be clear. It is recommended that you replace power steering fluid every five years or after 75,000 to 100,000 miles. For exact values, refer to manufacturer guidelines.
Transmission fluid is also a hydraulic fluid that serves the primary function of lubricating the vehicle’s gearbox. This allows gear transmissions to be carried out smoothly and efficiently, without any grinding between the internal components.
If transmission fluid is poor in terms of its quality, or if there isn’t enough of it, the gearbox can wear out over time due to friction, and gear transmissions can feel janky and rough.
Transmission fluids last a long time. Often, you don’t even have to worry about replacing them in your car’s lifespan unless you see signs of deterioration of the fluid or gearbox.
Transmission fluid can be divided into a few main categories:
As the name might suggest, this type of transmission fluid is used in most manual transmission systems that involve a clutch and gear for manual shifting. It is used in older vehicles; newer manual transmission vehicles are shifting towards the use of automatic transmission fluid for the additional benefits it provides.
It is thicker than automatic transmission fluids and comes in darker colors, such as brown. Most mechanics recommend that you replace manual transmission fluid every 30,000 to 60,000 miles.
Fun fact: Motor Oil can be used as manual transmission fluid. Even though it’s usually used to lubricate the engine, it has a somewhat similar set of properties to the ones required for manual transmission fluids.
Automatic transmission fluid is used in vehicles with an automatic transmission system. Besides providing the previously mentioned benefits of lubrication, this fluid also supports the automatic transmission system in carrying out gear shifts with the assistance of hydraulic pressure. It also acts as a coolant and ensures that temperatures don’t get too high.
It has a thinner consistency when compared to manual transmission fluid and has a slight reddish hue in terms of color. However, manufacturers have recently begun introducing their own colors, such as green and blue, to make their products stand out. It is recommended to replace ATF every 60,000 to 100,000 miles.
This form of transmission fluid is usually ATF created synthetically in a lab through chemical reactions. It is more effective in lubricating, breaks down slower, is less likely to oxidize, and provides users with numerous other benefits.
For further reading on the benefits of synthetic transmission fluids, refer to this article.
It can also be customized for specific vehicles. This category often offers the highest quality transmission fluid available.
For more information check our article about the Best Transmission Fluids and Additives.
First, it is apparent that power steering fluid and transmission fluid are different for the most part. They have different properties, different roles, and different purposes. However, ATF, in particular, is a type of transmission fluid similar to power steering fluid.
Their similarity lies in the fact that both of these liquids are hydraulic liquids built to deliver pressure to a different area.
In fact, there are automatic transmission fluids that can be used as power steering fluids. Usually not the other way around, though.
The answer to this is not definite and varies on a case-by-case basis.
Power steering fluid and transmission fluid are occasionally interchangeable. Automatic transmission fluid, in particular, can be used as power steering fluid. However, power steering fluid cannot be used in the place of transmission fluid as it lacks the modifiers present in transmission fluids.
Since both of these fluids are hydraulic fluids by nature, ATF can be used as a power steering fluid. It also has the added benefit of being able to remove dirt and grease from within the system.
However, this is not applicable to all vehicles safely. To find out whether you can use ATF in your power steering system, read the vehicle manual or consult an expert. In a bind, though, you can reliably use ATF; it will get the job done.
Unfortunately, this is not a safe practice. Despite being able to serve the hydraulic purposes of ATF, power steering fluid lacks certain detergents and modifiers present in ATF.
These detergents are responsible for the removal of dirt and grease from the transmission system, a build-up of which can lead to inefficient operation or damage. The modifiers within ATF are responsible for controlling the amount of friction and, consequently, the heat generated within the gearbox.
However, surprisingly enough, you can use power steering fluid as your transmission fluid in a pinch (not if your vehicle requires manual transmission fluid, though!). It will take care of the hydraulics, but if used for the long term, it can cause damage to your gearbox, so be careful.
It would be best if you did not mix power steering fluid and transmission fluid, as the difference in consistency and properties between the two types of liquids can cause inefficient operation in hydraulic systems. In worse cases, this can lead to complete failure of the hydraulic system – not something you want to risk.
You should only mix the same products (such as ATF with ATF) or products that are compatible with other products based on what the manufacturer states.
Power steering fluid and transmission fluid are not the same. Although they have a few things in common, they are designed for different purposes and have distinct features. They generally cannot be interchanged without negative consequences, but if you’re in a pinch, you can use ATF in place of power steering fluid and vice versa.
Using ATF as power steering fluid is usually safe (check your vehicle manual for confirmation). However, power steering fluid should only be used in place of ATF in an emergency as long-term use can damage components within the gearbox. | <urn:uuid:5bb9de9f-f69e-4618-8c07-59348ab32ac2> | CC-MAIN-2022-33 | https://carroar.com/is-power-steering-fluid-the-same-as-transmission-fluid/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.939504 | 1,504 | 2.25 | 2 |
Officials on both sides of the Channel fear the U.K.-Australia trade deal risks undermining efforts to ease post-Brexit tensions in Northern Ireland by securing a food- and plant-safety agreement between Brussels and London.
U.K. Prime Minister Boris Johnson and his Australian counterpart Scott Morrison announced a political agreement Tuesday on the broad terms of a trade deal, but the details are limited. Neither side published a full text of what has been agreed so far and chunks of the accord are not yet complete, with areas still requiring final drafting, two British officials told POLITICO.
Yet some drafting covering agriculture and seen by POLITICO suggests there would be fewer checks carried on Australian products, including fertilizers and meat, than is currently the case when they are imported by the EU. A British official said they believed that in these areas, plus others such as imported feed for animals, and other grains, fewer checks would lead to reduced enforcement of standards compared with EU practice.
“If the U.K. are agreeing to reduce the frequency of checks then that can only mean one of two things, either it believes the current rate of testing is needlessly onerous, or it’s prepared to accept a greater degree of risk than before,” said Dmitry Grozoubinski, a former Australian trade negotiator and founder of Explaintrade.com.
EU officials were already concerned that Northern Ireland might act as a backdoor into their single market and the liberalization of agricultural trade hinted at so far in the U.K.-Australia deal has added to their concerns, according to one EU official and a French diplomat.
“We’ve already been disturbed by a disregard for the need to implement the checks required by the protocol,” an EU official said. “This is opening the gates further if other goods from third countries are allowed in with less scrutiny.”
The Australia deal would be the first the U.K. has negotiated from scratch since Brexit. Others, such as the Japan deal agreed in September last year, were based on a roll-over of terms the U.K. enjoyed while a member of the EU. It is therefore the first one in which EU standards and enforcement requirements have not formed the starting point in negotiations.
It’s unclear what provisions the deal might contain in order to keep Britain’s commitments under the Brexit trade deal, the Trade and Cooperation Agreement, and the Withdrawal Agreement, the divorce treaty that includes the Northern Ireland protocol.
“While it was totally possible for the U.K. to do a deal with Australia and not jeopardize its ability to enter into a deep veterinary agreement with the EU, it will be interesting to see whether the U.K. chooses to diverge from EU approaches anyway so as to make it more difficult for this or a future government to reintegrate with the EU. A ratchet, of sorts,” said Sam Lowe, senior research fellow at the Centre for European Reform.
It is still not clear how Northern Ireland’s ability to benefit from London’s trade deals with third countries will work in practice. It was already not included in key quota calculations governing steel imports, leading to disruption for the industry. Brexit has also thrown up issues for exporters selling into the U.K. An example of this is meat-quota calculations that cut market access for New Zealand, according to the same British official.
There is also an apparent conflict in the application of trade-defense regimes between the EU’s and U.K.’s jurisdiction. Northern Irish producers impacted by unfair imports from the EU cannot take up their case with Brussels.
Asked about the impact of a trade deal with Australia on a solution to the post-Brexit situation in Northern Ireland a Downing Street spokesman said: “There is no interplay with wider issues.”
The Australian High Commission to the U.K. declined to comment. The European Commission didn’t respond to a request for comment ahead of publication.
What are your thoughts on the story? Let us know in the comments below! | <urn:uuid:8b7e2cad-46f9-4bdb-ae6a-12ea7102fb7c> | CC-MAIN-2022-33 | https://ec2-54-91-129-71.compute-1.amazonaws.com/brexit-uk-australia-made-a-trade-deal/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.965784 | 838 | 1.898438 | 2 |
A few short years ago, a noted estate garden outside of Charlottesville, Virginia, looked like a run-down city park. Poison ivy infested the boxwood borders. Tree roots buckled the herringbone-patterned brick walkways. The roses and perennials were long gone. But Virginia landscape architect Charles F. Gillette’s plan from the 1920s was still intact. It covered five acres, framed views of the Blue Ridge Mountains, and set off a nineteenth-century Georgian Revival house refined by 1920s society architect William Lawrence Bottomley.
Charles and Kimberlee Cory acquired Blue Ridge Farm in 2002 and learned that this sleeping beauty, one of many famous Bottomley-Gillette collaborations in the state of Virginia, was a rarity because no major construction had altered it. “We had no idea how long restoration would take, but we could see the beautiful bones Gillette laid down and wanted to see everything saved,” Kimberlee says. Charlottesville architect Madison Spencer was assigned the house renovation and led the Corys to landscape architect Rachel Lilly. Lilly was a natural for the job, since she’d worked on Gillette gardens for twenty-five years, following graduate studies at the University of Virginia School of Architecture, where she wrote a thesis on Charles Gillette’s garden design principles.
“Gillette’s private garden commissions are some of the finest from the twentieth century in America,” Lilly says. Known for park-like landscapes inspired by European country homes, Gillette’s gardens have often garnered national praise, including earning top honors in 1938 from the New York Architectural League.
For Lilly, the first step in uncovering the story of the garden at Blue Ridge Farm was tracking down Gillette’s references to the garden from all manner of sources—from Richmond’s Library of Virginia to the real estate brochures from the sale of the property. They provided some, but not all, of Gillette’s original planting plans. Lilly matched a 1928 plan of a geometric parterre—including a drawing identifying rose varieties—to an overgrown boxwood garden below the open lawn. “We researched the roses to figure out the colors,” she says. “All but two weren’t available, so we substituted floribunda, tea, and heirloom varieties.” Lilly also found and renewed the original cutting garden and combined Gillette’s three renditions of the entrance court into a simplified pathway. While some of the changes were obvious, such as removing a post-Gillette swimming pool, many were as subtle as reiterating brick mortar joints and other details Gillette favored. The attention to detail was worth it. “Saving old gardens from decay isn’t easy, and so many legendary places are now lost,” Lilly says. “I retrieved Gillette’s original plans because I was haunted by the beauty he created in the same way his clients were for more than a half century.” | <urn:uuid:9840fe5e-40b3-47d5-87ec-681eb2974350> | CC-MAIN-2022-33 | https://gardenandgun.com/articles/gillettes-gem/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.960672 | 623 | 2.15625 | 2 |
Donation to Einstein Ranks Sixth in all Gifts in 2013
Every year, The Chronicle of Philanthropy compiles a list of the top donations in America. Announced last month, the list included some familiar names – Facebook founder Mark Zuckerberg donated almost one billion dollars to a charity that focuses on community issues in his region. One donation, a $160 million bequest by the late real estate heiress Mrs. Muriel Block to Yeshiva University’s Einstein College of Medicine, clocked in at number six nationwide.
In April of last year, Dr. Allen M. Spiegel, Dean of Albert Einstein College of medicine, announced the start of the school’s largest fundraising campaign in its 60-year history: “The Campaign to Transform Einstein,” a concentrated effort to raise $500 million. In his announcement, Spiegel declared that the late Muriel Block had bequeathed a donation upwards of $160 million. “Muriel’s bequest—the largest gift in the College of Medicine’s nearly 60-year history—will greatly augment Einstein’s capacity to advance its mission to improve human health,” said Spiegel. “The gift will support important areas of research and has become the centerpiece of Einstein’s ambitious $500 million capital campaign.”
At the time of her death in 2010, Mrs. Block was considered to be one of Einstein’s most generous benefactors, donating almost $22 million in 2003 towards the construction of a new research facility – then the second-largest donation the school had ever received. “I considered Muriel a friend and partner in my work as dean of Einstein,” said Spiegel. “From our many conversations over the years, it was very clear that she derived great personal satisfaction from her ability to make a difference in helping to improve the human condition. She clearly had the vision to do something that would have far-reaching consequences and had great confidence in Einstein as an institution. Her final gesture of extraordinary generosity will have a terrific impact on our work.”
The bestowment, given in the name of Mrs. Block and her late husband Harold Block, will “significantly advance the College of Medicine’s goal of improving human health.” The money will be used to build “a new educational center for experimental therapeutics to develop novel treatments for unmet medical needs, personalized medicine, and genome sequencing, giving investigators the ability to evaluate the causes of a wide range of known diseases.”
“Gifts from Muriel Block and our other dedicated supporters…accelerate the paths to discovery, and yield measurable improvements in people’s lives,” concluded Dr. Spiegel. | <urn:uuid:5ce61e0f-79cc-49cf-90ee-2489835e3528> | CC-MAIN-2022-33 | https://yucommentator.org/2014/02/donation-to-einstein-ranks-sixth-in-all-gifts-in-2013/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.951922 | 563 | 1.765625 | 2 |
What ethnic groups make up Malaysia?
Malaysia has a complex multiracial population, predominantly defined by three major ethnic groups: Malay, Chinese and Indian races, with diverse cultural backgrounds.
What is the largest ethnic minority in Malaysia?
The largest ethnic group in the country is Bumiputera, a Malaysian term describing Malays and other indigenous peoples of Southeast Asia — it literally translates as son of the soil. In 2016, the population consists of approximately 68 per cent Bumiputera, 24 per cent Chinese, 7 per cent Indian, and 1 per cent others.
How do you determine your ethnicity?
Ethnicity is a broader term than race. The term is used to categorize groups of people according to their cultural expression and identification. Commonalities such as racial, national, tribal, religious, linguistic, or cultural origin may be used to describe someone’s ethnicity.
What are the three main ethnicity in Malaysia?
The largest group of Malaysians consist of three main races, namely the Malays, Chinese and Indians.
Which part of Malaysia has the most Chinese?
IN PRESENT DAY MALAYSIA: The Cantonese are the most urbanised of the Chinese community, with approximately 80% living in principal towns such as Kuala Lumpur, Petaling Jaya, and Ipoh.
Is Malaysia a multiracial country?
Malaysia is a multi–ethnic, multicultural, and multilingual society, and the many ethnic groups in Malaysia maintain separate cultural identities. … Their native language, Bahasa Malaysia, is the national language of the country. By definition of the Malaysian constitution, all Malays are Muslims.
What is the average salary in Malaysia?
In 2020, the average mean monthly salary in Malaysia was around 2.9 thousand Malaysian ringgit. The average monthly salary in Malaysia in that year varies greatly, depending on the education level, the employment sector, and especially between urban and rural areas.
Which race is the richest?
Which race came to Malaysia first?
The oldest complete skeleton found in Malaysia is 11,000-year-old Perak Man unearthed in 1991. The indigenous groups on the peninsula can be divided into three ethnicities, the Negritos, the Senoi, and the proto-Malays. The first inhabitants of the Malay Peninsula were most probably Negritos.
Is Malaysia a poor country?
Malaysia is one of the most open economies in the world with a trade to GDP ratio averaging over 130% since 2010. … Having revised its national poverty line in July 2020, 5.6% of Malaysian households are currently living in absolute poverty.
What was the old name of Malaysia?
Independence: Peninsular Malaysia attained independence as the Federation of Malaya on August 31, 1957. Later, two states on the island of Borneo—Sabah and Sarawak—joined the federation to form Malaysia on September 16, 1963. | <urn:uuid:413e35bc-0b25-4c50-8f4c-f6bc03792c93> | CC-MAIN-2022-33 | https://mientaysampancruise.com/southeast-asian-countries/question-what-ethnicities-make-up-malaysia.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.912517 | 669 | 2.859375 | 3 |
By Matthew L. Norman
NEW YORK, United States, Sep 26 2018 (IPS) - Each year as hundreds of billions of dollars are invested and critical decisions are made in agriculture, there is often little evidence or research to back these choices.
According to experts, this lack of data “leads to less than optimal decisions, causing losses in productivity, lost agricultural income, and ultimately more hunger and poverty.”
“The data gaps in agriculture are widespread, affecting 800 million, or 78 percent of the world’s poorest. The problem is especially dire in Sub-Saharan Africa, where nearly half of countries have incomplete information about the [agriculture] sector and farmers,” Emily Hogue, a senior advisor with Food and Agriculture Organisation of the United Nations (FAO), explains to IPS.
“Assessments have shown that those countries are able to meet half or less of their basic data needs, largely due to a lack of [agriculture] surveys.”
Citing the foundational role data plays in directing development efforts and monitoring progress towards the U.N’s Sustainable Development Goals (SDGs), the Gates Foundation, World Bank, FAO and others have launched a partnership aimed at investing in the agricultural data capabilities of low and middle-income countries.
Dubbed the 50 x 2030 Initiative, the plan aims to invest USD 500 million in data gathering and analysis across 50 developing nations by 2030.
On Monday, the governments of Ghana, Kenya and Sierra Leone joined the coalition in hosting an event at the U.N. General Assembly to announce the initiative. Panellists representing several of the initiative’s key partners shared the impetus behind their involvement.
Rodger Voorhies, executive director for Global Growth and Opportunity at the Gates Foundation, noted that “almost no country has come out of poverty in an inclusive way without agricultural transformation being at the centre of it.”
However, the panellists noted, the data needed to design evidence-based agricultural policy and target agricultural investments is severely deficient in many developing nations. This data gap represents a “critical obstacle to agricultural development,” according to Beth Dunford of USAID.
“There is no efficient path to meeting SDG2 or other [agriculture] development goals without improved agricultural data. Improved data will promote more effective targeting of interventions, improved national [agriculture] policies, and increased resources for the sector. As FAO is the organisation that is at the forefront of the activities to promote [agriculture] development and reduce hunger and malnutrition, we see filling in the agricultural data gap as a prerequisite to achieving agricultural development goals,” Hogue says. SDG2 is the goal to end hunger, achieve food security and improved nutrition and promote sustainable agriculture.
The 50 x 2030 Initiative’s announcement comes in the wake of the FAO’s recent revelation that world hunger has risen for a third straight year, with 821 million people worldwide facing chronic food deprivation.
Panellists emphasised that the data gap limits the ability of many nations to direct resources towards populations most in need, including smallholders affected by gender inequality or climate change.
The International Fund for Agricultural Development (IFAD) president Gilbert Houngbo, formerly the prime minister of Togo, observed that granular data could reveal regional, ethnic or gender disparities that are obscured by aggregate data. He recalled that during his time as Togo’s leader, progress in achieving inclusive poverty reduction was made more challenging because the country “did not have the disaggregated data to better adjust the implementation of our policies.”
In addition to driving better policy design and implementation, improved agricultural data will make it possible to better monitor progress in achieving the SDGs.
Claire Melamed, CEO of the Global Partnership for Sustainable Development Data, noted that many countries lack any data for several of the most critical SDG indicators, making it impossible to set a baseline and monitor progress towards the goals.
José Graziano da Silva, director general of FAO, explained that the initiative would initially focus on scaling up existing surveys of farming households. The FAO’s AGRISurvey is expected to expand to nineteen nations by 2021, and Graziano da Silva noted that this initiative would allow it to eventually expand to 50 or more. The initiative will also build upon the World Bank’s Integrated Surveys on Agriculture (ISA), part of the Bank’s Living Standards and Measurement Study (LSMS).
“The goal of this initiative is to have 50 low and lower-middle income countries (LMICs) with strong national data systems that produce and use high-quality and timely agricultural data for evidence-based decision-making. The survey programs are the vehicle through which we will build capacities and strengthen the institutions in those systems. We also aim to include the private sector, especially agribusinesses, as users and supports of these data,” Hogue adds.
Over time the initiative should allow more countries to take advantage of advances in data gathering and analytics. Laura Tuck, vice president of Sustainable Development at the World Bank, suggested that new tools for “real-time, high-definition data” would lead to smarter policies that increase sustainable food production. Tuck also noted that the structure of the 50 x 2030 initiative would allow countries the autonomy to drive their own use of data.
*Additional reporting by Carmen Arroyo in New York. | <urn:uuid:0a38630e-728c-4c34-8368-2735402bd788> | CC-MAIN-2022-33 | https://reliefweb.int/report/world/how-filling-agricultural-data-gap-will-fill-empty-plates | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.935511 | 1,137 | 2.890625 | 3 |
Pocket Linker is a device that allows data to be transferred back and forth NGP Ram card and any computer that has a parallel port. The advanced design of the NGP card and Pocket Linker makes it easy for programmers and coders to burn a ROM file to the NGP Ram card. To transfer data into the NGP Ram card, the only requirements are the Pocket Linker, PC and our customized software. No need for expensive and difficult to use EPROM burner. Parallel/Printer port - Pocket Linker has a built-in PC standard parallel/printer port, it does not require expensive PC parallel/printer port adapters and thus, there are no hidden costs involve. There are also no difficult, troublesome ISA/PCI cards to install and no need to dismantle the computer. User can use any computer without installing or dismantling any ISA/PCI cards. The Pocket Linker is hassle-free and works fine with all computers that has standard ECP PC parallel/printer port, including notebooks. Cartridge Slot - Standard original game cartridge compatible slot, works with NGP RAM card and any original game cartridge. Power Supply - Pocket Linker operates on a 7V-12V, 150ma or above DC power supply. The center point polarity of the power supply plug to the GB GameJack is negative (-). Battery Compartment - The GB GameJack has a battery compartment and fit Only 6 1.5VAAA size batteries. . Batteries are not used when Pocket Linker is attached to DC power supply. DC power supply does not included in the package. ASIC -Pocket Linker has a built-in asic fully developed by Bung.
|Boxed A||Game complete with manual and in VG-VG+ Condition|
|Boxed B||Game complete Good-VG condition|
|Boxed C||Game might have manual missing|
|D||Game Cartridge or Disc only| | <urn:uuid:10ebb87b-f780-4879-98ad-6dca30e1e355> | CC-MAIN-2022-33 | https://sorethumbretrogames.com/store/product/pocket-linker-neo-geo-flash | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.897954 | 399 | 1.765625 | 2 |
In continuation to our previous post about whether deafness is inherited or not, we at Compare DNA Kits were asked whether depression is inherited genetically or not. It makes no surprise that this is a popular question in the U.S or outside of it. In the USA, it is claimed that depression hits as much as 10% of the population at a certain point in their lifetime. In other countries the statistics are a little more murky around the statistics as a significant portion of the population which suffers from depression or other mental issues and illnesses goes undiagnosed (if you have no access to mental health locally – visit BestOnlineTherapy.com.
When it comes to whether depression is genetically inherited the most confusing statistics is this – the likeliness of having mental issues as someone whose parents or siblings suffer from mental illnesses is five times higher. That piece of statistics often hints people that genetics are involved, but genetics are far from being the only factor involved. The depression gene is a realthing, and depression is considered a partly genetically-inherited disease, but it’s not only the genetic but also the environment. In a previous article we have explored that very topic and realized that while some diseases are purely genetic, others such as cancer, are a mix of genetics and environment, as well as general maintenance of health.
If someone has inherited the “depression gene” and grew up with adults with mental illnesses then the likeliness of depression is high.
If someone has inherited the “depression gene” and did not have mental issues in the family or other traumas, then he is only slightly more susceptible to develop depression compared to the the population’s median average risk.
The bottom line is that depression is partly inherited genetically, and partly a product of the environment, upbringing and other factors. | <urn:uuid:93b129a2-f274-41e2-a4e6-cc40288105e0> | CC-MAIN-2022-33 | https://comparednakits.com/depression-genetic/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.972621 | 374 | 3.078125 | 3 |
Lupus-Induced Insomnia and a Feeling of Isolation
Part of living with lupus is knowing that your body lives outside of the norm. It means accepting that, for the most part, you have no predictable sleeping pattern, and if you should be lucky enough to regulate one, it’s pretty messed up. Living with lupus means you don’t live on the same timeline as everybody else, as yours is dictated by lupus. Sometimes that leads to a feeling of isolation.
I’m no stranger to late nights and late-starting mornings. Going to bed close to midnight and waking up well after everyone else is my preferred sleeping pattern. But lupus takes it to a whole new extreme.
For many people, going to bed well after midnight sounds horrific. I am often asked how I manage to keep myself up so late. Believe me, it’s not my choice — it’s lupus.
I’ve tried tiring myself out with exercise, drinking herbal teas, reading books, watching TV, and even meditating. Sometimes these work. But most of the time, I’m left lying wide awake and frustrated. The only thing that seemed to work is knocking myself out with sleeping pills. But in the morning they leave me feeling hungover and unlike myself, outweighing the potential advantages.
In a bad patch, I don’t sleep until at least 1 a.m., and I’ll be lucky to rouse myself before 11 a.m. My body needs rest, and while it’s incredibly important to listen and help myself wherever possible, sometimes it means that I live completely out of sync with everyone else.
Some people take my extended sleep-ins as laziness. Others see me as lucky, wishing they could sleep in past mid-morning, too. But what no one understands is that it all comes at a cost.
Have you ever been wide awake, begging for sleep while the rest of the world rests blissfully and unaware? I have, and it’s an isolating place to be. There’s a silence that only 2 a.m. knows, and when you’re exhausted but unable to sleep, it’s deafening.
Some nights I lie there listening to episode after episode of Big Bang Theory and hoping this will be the one I fall asleep to. But the all-too-familiar credit track rolls around once again and I hear another episode begin as I lie there, eyes closed, yet so far away from reaching sleep.
It’s hard to explain the feeling of exhausted restlessness. You feel so alone knowing that the people who would help you in any other situation are fast asleep. You have to face this alone. I can’t justify waking someone up just because I can’t get to sleep. It seems selfish and mean. But I hate the silence and waiting.
There are moments when time flies and I wish I could hold onto it with both hands. And then there are times like these. Moments when every minute stretches on for hours and I can’t bring myself to check the time. It’ll only remind me of just how long I’ve spent begging the night for sleep.
Note: Lupus News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Lupus News Today, or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to lupus. | <urn:uuid:45078643-e892-48a7-9a76-d2e7edf931e5> | CC-MAIN-2022-33 | https://lupusnewstoday.com/columns/lupus-induced-insomnia-causes-feeling-isolation/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.941642 | 816 | 1.71875 | 2 |
The Institute for Healthcare Improvement (IHI) Model for Improvement is one strategy many healthcare organizations make use of when they wish to put a continuous quality improvement process in place. This strategy makes use of an approach that involves establishing goals and bringing a team together to witness change. Any healthcare organization looking to improve in this area should consider the strategy when trying to determine how best to achieve this goal.
Create a Team
Bring together a team to work on the process. The practice determines the size of the team and the members. Often, this includes those who handle the day-to-day tasks in different areas, as they best understand what works and where changes are needed.
Decide what is to be accomplished with this process. Each goal needs to be specific, must have a timeline in place for achieving it, and must be measurable. The process needs to take this a step further and outline how its implementation will target a specific group and which group this is.
Put Measures into Place
Once measures have been established in the previous step, they must be enacted. Each measure must make use of data that can be gathered. This differs from organization to organization.
Identify Areas of Change
Examine the data that is gathered. Where are changes needed to see improvement? Make certain to obtain input from a variety of sources and begin addressing those changes that make sense.
Test New Methods
Once a change has been planned and implemented, it must be tested. Is it providing the desired output or outcome? If not, more needs to be done. For those changes that do bring about an improvement, it needs to be determined why it was effective so the information can be utilized to improve other areas of the practice.
Large Scale Implementation
When a change has been shown to be effective through testing and implementation on a small scale, it’s time to make it practice-wide. This should only be done, however, when it has been thoroughly tested and vetted. Moving forward too soon with a change often does more harm than good.
The IHI model is only one of several. Organizations need to consider all options to find the one that best meets their needs. Only then will the desired progress be seen and an improvement in healthcare observed. | <urn:uuid:6b0504f5-e2fc-43ee-b9b3-e374119b0aa9> | CC-MAIN-2022-33 | http://visdbs.com/2019/03/13/using-the-ihi-model-as-part-of-a-continuous-quality-improvement-process/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.952969 | 459 | 2.5625 | 3 |
Today, we’re experiencing a growing torrent of big data. Data for our retail purchases, Internet searches, social-media posts, and even our commutes to work reside somewhere. Not only do we cast a shadow on the ground when we walk in the sunlight, we all have data doppelgängers that show both our current state and the history of our lives. Our own data interacts with the data of other people—such as those who buy the same books on Amazon that we do or our friends on social media. All of this data interacts with the companies with whose products and services we engage.
Through machine learning and artificial intelligence, organizations can use big data to predict our next actions—sometimes even better than we can predict them ourselves. The implications of big data are enormous—enabling us to view suggested products while on a retailer’s Web site, receive recommendations to connect with people who we might know on social-media sites, and benefit from smart IoT devices that gather data from us and those who are similar to us, then act accordingly. Organizations in the healthcare and financial arenas use big-data systems to spot potential adverse events, while also pinpointing scenarios that can bring increased profits and positive outcomes. Read More
The world of UX design has seen rapid evolution in the last decade—much of it because of the value users have gained in the digital space.
Search engines consistently rolled out updates that penalized Web sites with crappy user experiences. Digital marketers woke up to the reality that—no matter how great their backlink strategy or the depth of their content—it was their Web site’s user experience that determined how users perceived and valued their site and the things on offer there.
But some big questions remain: What exactly is a good user experience? How do we define the specifics of what makes a good user experience? How can companies create good user experiences for their Web sites and apps? Ambiguity regarding the answers to these questions persists.
In Part 1 of this four-part series, I’ll discuss the negative impacts that some typical UX design approaches have had on businesses. Read More
Algorithms drive the stock market, write articles—but not this one—approve loans, and even drive cars. Algorithms are shaping your experience every day. Your Facebook feed, your Spotify playlists, your Amazon recommendations, and more are creating a personalized window into a world that is driven by algorithms. Algorithms and machine learning help Google Maps determine the best route for you. When you ask Siri or Cortana a question, algorithms help shape what you ask and the information you receive as a response.
As experience designers, we rely more on algorithms with every iteration of a Web site or application. As design becomes less about screens and more about augmenting humans with extended capabilities, new ideas, and even, potentially, more emotional awareness, we need algorithms. If we think of experience designers as the creators of the interface between people and technology, it makes sense that we should become more savvy about algorithms. Read More | <urn:uuid:1f869bf9-f2f5-4a71-a730-80899b91908f> | CC-MAIN-2022-33 | https://www.uxmatters.com/topics/business/big-data/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.944453 | 623 | 2.171875 | 2 |
Phone Battery Become User-Replaceable – With the advancement in technologies, the style and designs of mobile phones have also changed. Some phones have removable batteries, and some of them have batteries that are fit by the company when the phone was manufactured at the factory.
Should batteries become user-replaceable?
It is a deep topic, and there are too many reasons supporting the statement and going against the statement. First, we will talk about the sentences in favor of this topic. Then we will talk about all the topics that are against this.
User-replaceable batteries helpful when cell phone hangs:
Let us talk about the purpose of non-replaceable batteries. They were made by companies so that people can take them whenever they want and put them back inside. Most mobile phones are manufactured with the same design. Have you ever wondered how you will identify user-replaceable batteries? If you can open your cell phone’s back lid, there is a ninety percent chance that the mobile phone you are using has a replaceable battery.
To make sure, push the battery forward, and if it pulls out, it means the battery is user-replaceable. There are many benefits of using user-replaceable batteries. The first one is that cell phone users with user-replaceable batteries may take out the battery whenever they want. It is the reason why smartphone companies that manufacture cheaper phones include the option of user-replaceable batteries.
The quality of products used in these cell phones is low
But why are user-replaceable batteries vital in lower-end phones that cost less than one hundred dollars? I will explain using an example so that you can fully understand what I am talking about. It is because these cell phones do not have a lot of rams. Moreover, the quality of products used in these cell phones is low. If the quality is low, you won’t be able to use heavy applications on your cell phone. If you do, the side-effect you may face is that the phone will hang and stay there until you do something about it.
Most of the time, it gets stuck at that position, and users have no option but to restart their phones. The only way of restarting your cellphone is to take out the battery so that the phone shuts down and placing it back again. If you do this, you will be able to recover your cell phone to the previous state.
Saves cost while replacing a battery:
Fixing a cell phone can be very expensive sometimes. The maintenance cost is further increased when you have to repair a phone that does not have a user-replaceable battery. But why is it so expensive to repair cell phones that do not have user-replaceable batteries? There is just one reason for it. The reason it is difficult to open a cell phone. Opening the cellphone is a must to carry out maintenance as all the hardware is packed inside.
Cell phones are manufactured use machines in the factories. These machines are automated to fix the cell phone so that it remains intact even when it falls and hits the ground with a heavy force. If you take it to the shop to replace a battery, the person will charge a lot as he has first to gather his tools and try opening the cell phone. The first thing he will do is open the screen. Hess screens are usually located on the bottom of the cell phone.
Cell phones are manufactured use machines in the factories
When the screws are removed, the person may lift the cell phone slightly, but that is not enough. He has to remove and wires attached to the body. The next step is to carry out a procedure to separate the adhesive from the body. The adhesive glue holds the cellphone intact. After the adhesive is removed, the user may be able to take out the battery. This procedure is quite costly as it requires a lot of effort, patience, and skill.
However, if you had a cell phone with user-replaceable batteries, you did not have to go through the process of removing the screws and the adhesive. It is because the user can access phones with user-replaceable batteries. A phone with user-replaceable batteries has a lid at the back of the phone. When you open the lid, you will be able to access the battery. If you think your battery is not performing, you have to go to a nearby shop and ask for the cell phone battery.
When you receive the battery, remove the old one and put the new one. Hence we can say that people having cell phones with user-replaceable batteries do not have to go through the trouble of opening up the whole phone. As a result, they save a lot of money.
User-replaceable batteries cause less damage:
Yes, it is true. User-replaceable causes less damage to the phone. Most of you might be wondering how batteries will cause damage to our cell phones. Well, batteries contain lithium, and lithium can be dangerous when the phone is not used properly. Most of the time, it is not the fault of the user. The factories tend to have a default in the phone, due to which they start to malfunction and cause problems for the cell phone and the cell phone users. You must be aware of the cellphone produced by Samsung. These cell phones were called the Samsung Galaxy S 7. This phone had a battery issue, and it used to explode in the pockets of people. Interestingly, the phone was idle and was not used by anyone, and it exploded.
The Samsung galaxy s7 was also a phone
The Samsung galaxy s7 was also a phone that had a battery that the user could not replace. It means that if you wanted to change the battery, you would have to take it to the shop and get it replaced. Most of you might be wondering how these phones will cause more damage. I will explain this using an example so that you may understand fully. Suppose you have two bombs. You place one bomb inside the car and the other bomb on the surface of the car. Which bomb will cause more damage? The bomb inside the car will cause damage.
Batteries are made out of lithium, and if the liquid from these batteries overflow. It can cause damage to the cellphone. When the battery is non-user-replaceable, it would be fit in the middle of the phone. So, if the lithium inside the battery reacts and explodes, all of the phones will be damaged. But if the battery is placed on the outer layer of the phone and only has a lid over it, it will not cause damage to the cell phone when the battery explodes. Only the lid will be damaged. As a result, the money for repairs can be far less if the phone has a user-replaceable battery.
Saves battery when a phone gets waterlogged:
You must have gone through those horrible experiences when you take your cell phone to the shower and drop it in the tub. Or you have gone on a vacation with your family, and you drop your phone in the water at the beach. First of all, you should understand that water and electricity do not go together. Extreme care should be taken when we talk about electricity inside the battery. The battery consists of dry chemicals inside. These chemicals are wrapped in such a way so that they can be protected from the moisture in the environment.
So, what happens when water reaches your battery? When the water reaches the battery. It will reach the chemicals inside, and hence your battery might not work ever again. The dry chemical inside the batteries is jotted wet, and hence it will stop functioning. Moreover, cell phones with wires in the cell phone that are not protected might also catch fire, and the phone might be damaged forever.
A cell phone that has removable batteries can save itself from buying a new phone. So what do you have to do when your phone falls in the water? The first step is to open the lid and take out the battery. It is vital to take out the battery, and there are two reasons to do so. The first reason is to protect the battery from getting wet, and the second reason is to protect the phone from short circuits.
The cell phone has several circuits inside it
The cell phone has several circuits inside it, and those circuits may be harmed if water touches them. Moreover, the motherboard may also blast a fuse, and you might have to replace the whole motherboard. It can be expensive. All of the happens when the current is flowing inside the cell phone.
If we can make out the battery within a few seconds when the phone drops inside the water, we will save the phone. It might not be possible if we had a cell phone which had a non-replaceable battery. By the time you take out the nonuser replaceable battery, the circuit would have been damaged. Moreover, another advantage of the user’s replaceable battery is that you might dry it out in the sun and use it again.
Replaceable batteries have longer battery life:
If you want a cell phone with a battery that can last for a longer time, you should go with replaceable batteries, and non-user-replaceable batteries do not give battery life. Battery life is essential nowadays as people have a lot of work to do during the day, and most of the work is on their cell phones. Mobile phones nowadays are equipped with the latest features. These features help out the local people in their daily tasks.
Some of these features are writing down notes, using the calendar, recording videos, etc. These features consume a lot of battery, and it would suck if you had to carry around a power bank or a charger all the time to keep your cell phone charged. Moreover, it is a business tactic of cell phone manufacturing companies as it increases their newly launched products.
These companies install batteries in their cell phones
These companies install batteries in their cell phones so that the users cannot remove them. Battery performance is reduced when two years pass by. Even apple claims that battery performance reduces 20 percent after 500 charge cycles. It is because the chemical inside the batteries has exponential decay. Once a battery gives less performance, the user has two options.
The first option is that he changes the battery and the second option is that he changes the cell phone. Non-user replaceable batteries cost a lot of replacement as the cell phone has to be opened fully by the cell phone company. So, most people consider buying the newer version of the cell phone rather than spending money on changing the cell phone battery. If the cell phone had a user-replaceable battery, it could be easily changed.
Cell phone with fixed batteries is waterproof:
Cell phones that have non-user-replaceable batteries have are waterproof. It means that it is difficult for the water to penetrate deep inside the cell phone. But why is this so? When cell phones are made, the company takes great care in making the cell phone durable so that people do not face issues such as waterlogging. Moreover, it increases the reputation of cell phone companies.
Cell phones that have non-user-replaceable batteries give the company full right to design the phone from inside so that it is safe from water damage. First of all, the battery is placed in the middle of the phone, so even if the water enters the phone, it will take a longer time to reach the battery and damage it. Moreover, you must have noticed that cell phones that have nonuser replaceable batteries are slim in size. It is because the components are packed into each other, and there is no room for air. It is what makes the phone so slim. When the components are packed together, there will be no space for water to flow inside the water, and hence it is waterproof.
Moreover, the back lid is tightly placed over the phone to seal the battery and protect water from entering the phone from the backside. If you had a cell phone with a removable battery, the water would enter from the cell phone’s backside and damage it.
Cell phones with non-removable batteries are more secure:
All cellphones have a tracker placed inside them. Most of the time, this tracker is placed under the battery. When you lose your cell phone, the thieves remove your battery and then go on towards removing the tracker from your cell phone. Once the tracker is removed, the cell phone will not be traced.
If you have a cell phone that has a removable battery, it will be easy for the thief to remove the battery and the tracker below it. Moreover, he will remove the sim card, so it becomes even more difficult to track your cell phone. However, that is not the case when you own a cell phone that has a non-removable battery.
If such a phone gets stolen, the first thing the theory has to do is to figure out taking the battery out. It is not possible as he has to unscrew the screen the backlit and take out the battery. It would be time-consuming, so he won’t even hesitate to open up the cell phone. As a result, it would be easier to track the cell phone. Moreover, if the thieve takes longer, the phone will be tracked. Most of the time, these thieves throw away cell phones.
We can conclude that we should have cell phones with removable batteries because they are easier to manage. Moreover, if the water penetrates them, these batteries are available and changed at a low price. Phones with removable batteries are much cheaper than cell phones that have non-removable batteries. | <urn:uuid:9092889b-71a7-4cae-8197-a31a14f8cd0c> | CC-MAIN-2022-33 | https://alltechtalks.com/phone-battery-become-user-replaceable/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573744.90/warc/CC-MAIN-20220819161440-20220819191440-00472.warc.gz | en | 0.961613 | 2,789 | 2.09375 | 2 |
A 31-year-old member asked:
Can you repeat cardioversion even if it did not work the first time?
2 doctor answers • 3 doctors weighed in
Cardiology 37 years experience
Yes.: Yes, it can be repeated three or four times at incrementally higher voltages each time.
6.2k viewsReviewed >2 years ago
Cardiology 59 years experience
Yes: We can cardio vert with higher current or additional antiarrhythmic drugs to be effective if needed.
5.5k viewsAnswered >2 years ago
Last updated Nov 27, 2020
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Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency. | <urn:uuid:08789049-4a85-4694-942a-e8700efca63e> | CC-MAIN-2022-33 | https://www.healthtap.com/questions/16547-can-you-repeat-cardioversion-even-if-it-did-not-work-the-first-time/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.906742 | 234 | 1.59375 | 2 |
url = 'https://blogs.mathworks.com/images/steve/2008/book_text.png'; text = imread(url); bw = text(1:500, 1:500); imshow(bw)Suppose we want to identify characters containing a tall vertical segment. We can do this by opening with a vertical structuring element. Erode first:
se = strel(ones(51, 1)); bw2 = imerode(bw, se); imshow(bw2)Then dilate:
bw3 = imdilate(bw2, se); imshow(bw3)Or you can do the opening in a single step by calling imopen:
bw3 = imopen(bw, se); imshow(bw3)The dilation step in the opening operation restored the vertical strokes, but the other strokes of the characters are missing. How can we get the entire characters containing vertical strokes? The answer is to use morphological reconstruction. For binary images, reconstruction starts from a set of starting pixels (or "seed" pixels) and then grows in flood-fill fashion to include complete connected components. To get ready to use reconstruction, first define a "marker" image. This is the image containing the starting or seed locations. For our text example, the marker image will the output of the erosion.
marker = imerode(bw, se); imshow(marker)Next, define mask image. The flood-filling will be constrained to spread only to foreground pixels in the mask image. We can use the original text image as our reconstruction mask.
mask = bw;Finally, call imreconstruct to perform the operation.
characters = imreconstruct(marker, mask); imshow(characters)Performing morphological reconstruction, using the eroded image as the marker and the original image as the mask, is called "opening by reconstruction." Do you have other uses for morphological reconstruction in your own applications? Tell us about it: Click on the "Comment" link below.
To leave a comment, please click here to sign in to your MathWorks Account or create a new one. | <urn:uuid:8d866d50-fbc8-4689-8a38-57f5945724ac> | CC-MAIN-2022-33 | https://blogs.mathworks.com/steve/2008/07/14/opening-by-reconstruction/?s_tid=blogs_rc_3 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.847762 | 467 | 3.203125 | 3 |
by Mila McManus, MD
When you use a good quality olive oil for cooking, it’s not doing for you nutritionally what you expected it to do. While it has been determined that olive oil is more stable with heat than originally thought, the fact remains that the longer it’s exposed to heat, and the higher the heat, it will be damaged and make the oil toxic to your body.
So, when roasting your olive oil coated vegetables in a 350°+ oven, the olive oil will be molecularly damaged. You thought it was healthy, but really it’s not. Rather, you have made an unusable anti-nutrient for your body. Your body will respond with inflammation and congestion. The same is likely true for avocado oil.
Keep in mind that the higher the heat, and the more prolonged the heating, the faster the degradation of the molecular structure. It may be alright to gently, patiently, slowly sauté something on low to medium low on the stovetop for less than 15 minutes, and successfully avoid damaging the oil. Patient and slow are not common methods for most of us in the kitchen these days. Besides, why cook in olive oil when there are so many better options that also enhance the flavor of our food?
Here are some tips: First, it’s fine to apply olive oil after cooking is complete where this makes sense. Olive oil is good when used for cold preparation in salad dressings and hummus, for example. Second, in terms of roasting vegetables, try putting the roasting pan with butter in the oven while preheating and cleaning your vegetables. Then remove it from the oven, put your vegetables in the hot melted butter and toss them until coated. This works well with any saturated fat (e.g. coconut oil, ghee, lard) and is just as fast as olive oil when you consider the wait time for the oven to preheat anyway.
There are many heat stable saturated fats with which to cook. Normally, at room temperature, these will be more solid, though that may fluctuate with the temperature in your house. Examples include pasture raised butter or ghee, duck, beef, pork fat, and coconut oil. Check out epicprovisions.com for good options. Reserve bacon fat from uncured bacon for cooking. When using the highest heats such as broiling or on the grill, consider ghee to be the most stable. One excellent brand is 4th & Heart (fourthandheart.com) and they offer various flavors. Ghee is normally found on the olive oil aisle of the grocery store, not in the diary section. It is normally soft enough to use a silicone brush to coat a pan, or spread on vegetables or fish, for example.
Take caution when you purchase olive oil. Most olive oils are tarnished and impure, as well as counterfeit, having other added oils such as soybean, grapeseed, or canola oil. Many have been discovered to have toxic chemicals too. Here are tips for purchasing quality olive oil:
- The more information provided on the label, the better.
- A harvest date no more than one year old.
- Know that there is no regulatory significance of terms like “first cold pressed, or “extra virgin”, so don’t let that lead you.
- Look for third party certifications that promise higher standards such as “COOC Certified Extra Virgin”( California Olive Oil Council) or EVA (the Extra Virgin Alliance) and “100% Qualita Italiana”, by UNAPROL, the association of actual Italian olive growers. Interestingly, little stock is put in a USDA organic certification!
- Chile, Australia, followed by the US, have better practices and stricter standards in general according to the U.S. International Trade Commission report on the quality of extra-virgin olive oil. These may be the best “go to” sources of origin when in doubt.
- Newer oils are always better. Be sure to buy small quantities (a six week supply) as it is highly perishable. It should not be exposed to heat or light and is best stored in a cool, dark cabinet. Tins do the best job of blocking the light, followed by an opaque glass bottle. Oxygen is also an enemy of olive oil so once opened, the oil quality is going downhill quickly.
Reduce inflammation and increase nutrition by using oils correctly. Eat Well. Be Well.
¹ Real Food/Fake Food by Larry Olmsted, Algonquin Books of Chapel Hill, 2016. | <urn:uuid:eb52f324-c575-4c37-a328-523bc265cf2d> | CC-MAIN-2022-33 | https://woodlandswellnessmd.com/stop-cooking-with-olive-oil.html/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572833.95/warc/CC-MAIN-20220817032054-20220817062054-00472.warc.gz | en | 0.946292 | 957 | 2.515625 | 3 |
Boost your casflow by $400 a month
by Greg Carroll at www.attitudefinance.com
There is no doubt there are a number economic factors going on at the moment that are outside all of our control. And while it is easy to dwell on these factors I'd prefer to focus my attention on the things that can be controlled. So today I'd like to look at a number of strategies that you may be able to use to offset some of the rising living costs.
Knock $400 a month off your home loan repayments
Imagine if you could save $400 a month in expenses. Would it make a difference? That's $4,800 a year. That might cover school fees, offset the cost of petrol, help with the groceries or cover an end of year holiday. And depending on your situation you may be able to make a bigger saving. I'll use an example to illustrate.
Michael and Sandra's home loan is $300,000 and is 5 years into its term. Their current rate is 9% and their repayments are $2,517. By simply restructuring their loan over 30 years and keeping the same rate they can reduce their repayments to $2,414 a month.
Not a bad start but they can go further. Through another lender I use they are able to access a lower rate of 8.46%. Through a restructure they are now able to reduce their payments to $2,298 per month.
A bit more of a saving but they can go one step further. If they also put their lending on interest only for a period they could reduce their monthly commitment to $2,115 per month. A saving of $402 a month.
With most interest only loans you can still make additional reductions at any time. So you could still tip extra into the loan. But on those months when all your expenses seem to hit at once you can just pay the interest. So you have not only reduced your expenses but have added some flexibility.
If you would like more information on this loan contact me on 07 3666 0110 or contact us
And maybe a bit more
If Michael and Sandra had a credit card for $10,000 which was costing them around $250 a month they could also roll this into the loan which would reduce the commitment to $70 per month. Therefore a total saving of $582 a month.
Rolling cards into a home loan turns a short term debt into a long term debt but if you have been trying to reduce your card for a while and not making any headway then it is probably worth looking at. If you do go down this path I would still suggest implementing a reduction programme for this portion of the debt. For example on a rate of 8.46% with a repayment of $250 per month it would be possible to pay off a $10,000 debt in approximately 4 years.
You need to weigh it up
There is no doubt there are pros and cons with debt consolidation and switching to interest only but if you are seriously finding it tight particularly in light of the other cost pressures then it is worth reviewing your position.
The recent changes to stamp duty announced by the State Government will also offset some of the switching costs.
Investors also have some more options up their sleeves
For investors the early period of holding a property can place some pressure on cashflow particularly with the current rate increases.
There are however a number of strategies that can be adopted to minimise the impact on cash flow. In fact in may even be possible for investors to accelerate the reduction of their home loan debt in the process. Let's look at an example.
Bill and Lori Jones are planning to purchase an investment property for $350,000. Their home is currently worth $600,000 with a home loan of $252,000. Estimated purchase costs are $14,214. Starting rental is $310/week. Average annual growth is 7%. Bills earns $85,000 pa and Lori $25,000. Their living expenses are $1,000 per week.
A possible way for Bill and Lori to structure this purchase is as follows:
Under this structure:
· They are still financing 100% of the purchase price plus costs, maximising their tax deductions ($84,615 + $280,000 = $364,615).
· They are separating each property so they are not cross-securitised. This means in the future they can refinance or sell one of the properties without affecting the other and avoid potentially higher costs.
· They have provided themselves a buffer of $143,385 to assist with funding the investment property.
So that is a good start but here is where Bill and Lori can really turn this structure to their advantage:
So what affect does this have?
Let's have a look at TABLE 2 below to see the result in more detail:
So in just over 5 years Bill and Lori have shifted their non-deductible home loan across to the deductible side of the ledger. This is possible under a particular structure called Global Facility Limit structure.
Based on the above assumptions the investment property would be worth $490,893 and their own home would be $841,531. A total of $1,332,424. Their total debt is $306,998 plus the investment loan $280,000 - $586,998. Giving them a net worth of $745,426.
Interestingly if they had not purchased the investment property and instead paid all their surplus income after living expenses into their home loan each month it would take them approximately 17 years to pay off their home loan.
Used with good budget discipline it can be a highly effective wealth creation tool. This is an option that many investors would be able to utilise. Will it work for you? That really depends on your specific circumstances. The best way to find out is to contact us for an initial discussion.
If you would like to look at some scenarios for your own situation then contact us or phone 07 3666 0110
This information is not a substitute for independent professional advice. We do not warrant the accuracy, completeness or adequacy of the information or material in this article. All information is subject to change without notice. We and each party providing material displayed in this article disclaim liability to all persons or organizations in relation to any action(s) taken on the basis of currency or accuracy of the information or material, or any loss or damage suffered in connection with that information or material. You should make your own enquiries in relation to tax, risk and your personal situation before entering into any transaction on the basis of the information or material in this article. | <urn:uuid:176059bb-5f32-4961-be3a-2078c14e6cc2> | CC-MAIN-2022-33 | https://mtafinance.com/boost_your_casflow_by__400_a_month | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.962528 | 1,375 | 1.757813 | 2 |
Two measurement systems in one!
Swift PRO Duo is the only video measuring system to incorporate an ergonomic measuring microscope. Previously difficult-to-view samples can now be measured and inspected on the same system, in the same routine, by the same operator. Swift PRO Duo provides fast and accurate measurement of both routine and complex precision parts. With a rich suite of measurement and reporting features, it is the right measurement tool for a broad range of applications, from electronics and aerospace to automotive, plastics and medical device manufacturing.
- Optical microscope and video measurement system in one
- Up to 200mm x 100mm measurement stage, 5μm stage accuracy
- Advanced and robust measuring system in a compact size
- Designed especially for toolmakers and shop floor operators
- Take accurate measurements in seconds, with no need for pre-programming
- Z-axis variant for height measurement
- Patented optical ergonomic microscope offers high resolution surface inspection
- Ideal for use on the shop floor and in the QC lab
Why video and optical measurement?
Dual video and optical measurement technologies provide the best of both worlds, so whatever component you are measuring, you can be sure you have the best tools for the job, in a single system, without any hold-ups.
Video measurement is ideal for routine components where edges of features can easily be identified.
The smart video measurement tools allow the operator to quickly detect and measure features accurately and repeatability.
The advantage of video edge detection is the practicality and overall speed of measurement.
In order to take an accurate measurement, you need to clearly identify the edge of the feature being measured.
Swift PRO Duo incorporates the patented Dynascope® eyepiece-less measuring microscope, providing high contrast, microscope-resolution image of your components.
Superb optical clarity with the Swift PRO Dynascope optical head
Complex, or difficult-to-view features can be viewed in intricate detail, ensuring you can take accurate measurement of all you components, not just the easy ones! The superb microscope image also allows for high resolution visual inspection.
When measuring features without clear edges a video camera may be unable to detect the edges due to lack of contrast and this is where optical measurement is beneficial. The high resolution crisp image from the optical head enables you to accurately select features to measure. Typical examples of this would be for clear or black plastics and surface features on metal parts (where there is no contrast between the feature and the background).
Seamlessly switching from video measurement to optical measurement in the same routine, without delay, you can have the best measurement tool available all the time.
Swift PRO Duo is the only system available to include the unique and patented eyepiece-less ergonomic measuring microscope.
The Dynascope® technology allows operators to take accurate measurements whilst wearing prescriptive glasses, safety goggles and contact lenses. Other system benefits include a large field of view and peripheral vision.
Measuring stage calibration, with NLEC
Swift PRO Duo includes Vision Engineering's proven 200mm x 100mm precision measuring stage.
The stage comes complete with factory-set Non-Linear Error Correction (NLEC) calibration to ensure optimum accuracy, traceable to international standards for the purposes of ISO9000.
Swift PRO Cam comes with a choice of industry leading M-series metrology software or robust QC 3000 microprocessor.
M-series measuring software
Renowned M-series software carries out basic to advanced measurement applications with ease and with minimal training. Intuitive user interface would appeal to a wide user base, ranging from machine operators on the shop floor to metrologists in the QC lab.
- Intuitive PC-based metrology software enabling viewing on large monitors
- Quick profile and surface measurement without pre-programming
- Programmable light control
- Easy reporting
- CAD like Part View mark-up for easy inspection of the measured data
- DXF import/export
- Thread and wire measurement options
- Multiple video tools, from cross hair to full video edge detection
QC 3000 microprocessor
Thanks to its sleek but robust industrial design, the QC 3000 is ideal for applications in a harsh production environment to measure 2D geometric features quickly and easily.
The flat aluminum housing with integrated power pack and fan less passive cooling is extremely sturdy and tolerant to negative influences.
QC3000 Heidenhain microprocessor for Swift Pro
The 12.1" touchscreen of specially hardened glass supports multi-touch gesture control and can be operated with gloves.
- Shortcut icons for measurement of common geometric features (e.g. point, line, circle, slot and rectangle)
- Video edge detection (VED) provides multiple tools for edge detection and selection of points for measurement
- Measure the points manually or automatically
- Easily create reports generated immediately after measurement
- Robust IP65 splash proof touch screen panel, ideal for the shop floor | <urn:uuid:bb9b9125-1825-4e98-9c14-630f14040e02> | CC-MAIN-2022-33 | https://measurementsupply.com/products/vision-systems/vision-engineering/vision-engineering-swift-pro-duo | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.899047 | 1,037 | 1.546875 | 2 |
In the world of small town zoning there is the concept of the “buffer”. The buffer is akin to the roll of super absorbent paper towels produced on the home-front after an accident has occurred.
So, lets say the City planners locate Industrial zoning in a low income neighborhood next to houses. Such a fence can be required as a buffer.
Screen 3 (“S-3”). The S-3 buffer/screen requires an opaque landscaping scheme, one that blocks views between two adjacent properties. This type of screening is for use between dissimilar land uses, where the maximum amount of visual shielding is desired. The plantings allowed by the S-3 designation consist of the following…
…With the approval of the director, an opaque wall or fence may be utilized for, or as part of, a required S-3 screen. Where allowed, such wall or fence (including any gate(s) forming a portion of such structure) shall be at least six (6) feet tall, or an alternate height deemed necessary by the director to protect required sight distances along a public right-of-way.–CHO Code 34-871
Does the fence stop the noise? Does it stop the smell? Does it block the view of the 85 foot tall manufacturing facility? No.
But it makes the planners feel they have done their job. | <urn:uuid:23c9e9ea-3221-469c-a357-7f6254f52706> | CC-MAIN-2022-33 | http://billemory.com/blog/2011/03/fence/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.929136 | 281 | 2.1875 | 2 |
Where does the suggestion of a £200m loss to the exchequer come from?
That was the claim made by the Professional Footballers’ Association last week. It was made in response to a Premier League proposal that players should agree to a reduction in their wages of up to 30% during the coronavirus crisis.
The PFA said: “The proposed 30% salary deduction over a 12-month period equates to over £500m in wage reductions and a loss in tax contributions of over £200m to the government.”
There has been debate over whether this number was accurate, but according to Nimesh Shah, a partner at the accountancy firm Blick Rothenberg, it is likely an underestimate.
“Most Premier League players will be earning way over £150,000 a year so will be paying 45% rate of income tax,” he says. “Then there is national insurance, which would add to that calculation.”
With the total annual wage bill of the Premier League standing at £1.6bn annually, according to the 2019 Global Sports Salary Survey, a 30% cut would amount to £480m. Based on that figure, the amount of lost tax would be £216m in income tax and £9.5m in NI, giving a total of £225.5m.
But what if the wages were given to charity?
That has been the implication of some of the criticism emanating from politicians, with the health secretary, Matt Hancock, directly comparing the intransigence of footballers to the sacrifices of NHS workers, while the culture secretary, Oliver Dowden, has asked footballers to make a contribution to the “National Effort”.
Premier League captains are setting up a fund to donate money to the NHS and charitable causes. But Shah suggests that any charitable donations may only hit the government further in the pocket.
“Donations to charities have their own implications wtih regards to tax, with a whole myriad of positions that could follow,” he says. “Clubs could get tax relief on their donation, players could too and they would get extra relief from being a top rate tax payer. When an individual makes a donation the government must also top it up with gift aid. That could end up costing government even more.” | <urn:uuid:26aa03b3-377e-437c-a376-7c52553c0f57> | CC-MAIN-2022-33 | https://sortiwa.com/would-a-premier-league-pay-cut-really-cost-the-government-200m-football/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.972295 | 502 | 1.59375 | 2 |
Reading through an entire book can take weeks if not months. If you are trying to improve yourself and learn new ideas and concepts, this can be a serious halt in your progress. Learning how to read faster without losing comprehension can save you so much time!
I am an avid reader myself and I am constantly reminded of how thick the books are that I am trying to read.
This made me very frustrated. I have always had a massive list of books that I need and want to read. So if I took months to finish a single one, it made me feel as if I will never get to the bottom of my reading list.
That’s when I realized there is a large list of tips and techniques, that if applied correctly you will be able to double and maybe triple your reading speed (without losing comprehension).
There might even be specific habits that are holding you back. We will be diving deep into speed reading and how to read faster.
Tips on How To Read Faster Without Losing Comprehension
Guide Your Eyes
This is a very easy & simple tactic you can start the next time you read. Have you ever felt like you have read the same line 3 times in a row?
The problem with our eyes is that we don’t track in straight lines. So, it can be very helpful to use your finger or a pencil to help guide your eyes along. This ensures you are not, skipping lines or reading the same one over and over again.
Headlines & Reading What’s Important
Every book you read probably has a few great ideas and concepts in it. But they needed all the extra pages to be able to sell the book. You can get these great ideas from every book by just skimming through and looking at chapter titles and the headlines. Each chapter usually has a main idea. Then multiple examples to back up this claim. You don’t always need to know every example.
Often times the first and last sentences of chapters are able, to sum up, each section. Neither of these principles will hold true for every book you read, but it will hold true for more than you think.
Now I know what you’re thinking. I won’t be able to remember anything. It just takes practice, what you need to do is start reading just past your level of comfort. Where you are losing a tiny bit of comprehension.
Once you are able to get used to this, then you can slowly increase the speed from there.
Read What Interests You
Some of you might have to read a book for a certain class or to receive credits. But in your free time make sure you are reading books that interest you.
For myself, I like to read books on Investing, Health, and Personal Growth. But maybe you like to read about Relationships, Psychology or Fitness. Whatever it is, focus on that.
Just remember if you don’t care about it and your only reading it because someone else told you that you should, it is unlikely that you will be able to finish the book and that it will have any impact on your life.
While you learning how to read faster without losing comprehension, you are going to be tempted to give up! If you need help persevering then learn How To Improve Your Self Discipline.
Use Your Peripheral Vision
This one has the potential to double your reading speed altogether. When you look at an object, you are able to see other things around it.
This is called your peripheral vision. To practice using it while you read, draw a line down the side of your page on each side. About one inch into the page.
Then read just like normal and don’t let your eyes go beyond that vertical line. Keep practicing it and you will eventually be able to move the line further and further until you are able to focus on the inside third of the page.
This tactic helps you practice using your peripheral vision while reading.
When you read, you are more than likely saying each word as you go along. This is happening subconsciously. This is not necessary, it takes up too much time. Create the habit of skipping words that are unimportant.
In most cases the bigger the word the more important it is. Focus on skipping the smaller words, then reading the bigger more important ones.
Getting ahold of a book summary can be a fantastic way to educate yourself and be as efficient as possible. I do this myself all the time. You can watch or listen to a book review to understand the subject in a condensed format instead of taking hours of time to read the whole book.
This not only saves time but money as well. Like I said earlier, a book is usually about a few important concepts and then filled with other examples. The author needs an entire book to be able to sell it.
Learn more about book summaries and audiobooks here: Audible vs Blinkist
Get Rid of Distractions
It is much more difficult to simply ignore the distractions than it is to get rid of them. It can be very hard to understand complex concepts when there are so many distractions around you.
Once you get interrupted you take your attention away from the book. When you try and bring it back and you have to try and remember where you were and what was happening in the book.
This can waste a large chunk of time during this transition period.
Ensure you finish all your small tasks right before you go into a reading session. This way you can limit the number of distractions that could happen while you are trying to read.
Listening to audiobooks can be a great use of your time. Replacing audiobooks with music is a great idea. One thing you could try out is listening to audiobooks while you are driving or doing some chores. The amount of knowledge you could attain on your drive to work every day is unbelievable.
Another huge benefit of audiobooks is you can speed up the rate at which the book is read. This gives you the ability to finish the book in half the time it would normally take.
Using audiobooks is the best way I learned how to read faster without losing comprehension.
A lot of people have the habit to go back and re-read full pages or chapters to make sure they didn’t miss anything. But in reality, they understood most of the key points.
When you go back and re-read, you break the flow. When you are in this flow you read at a very fast pace and are able to understand what the author is saying. But when you stop to re-read a sentence it throws you and your brain off.
Most people do this without recognizing it. If you really missed something or you don’t understand it’s always okay to go back and re-read, just make sure you are only doing it when necessary.
Put Your Knowledge to Use
Everybody should be implementing this tip, or there is no use in reading in the first place. The goal is to take the knowledge you acquire from these books and apply it to your life. It helps to take notes of all the important parts. So later you can look up what you learned and go use it in any area of your life.
It also helps to pick a book about something that you are struggling with.
For example, if you are having trouble saving money, find a book about money management. If you do not apply what you learn into your life, then the time you spent reading has been wasted.
Not only does this help you apply what you learn, but when you are interested in what you are reading it helps you find the motivation to read more often. This can lead to more reading sessions than you usually find the time for.
Understand The Benefits of Reading
Some people are unaware of the overwhelming list of the benefits of reading. Reading has the potential to truly change your life.
If you are interested in learning all the benefits of reading check out, Why You Should Read Books. When you understand the benefits of reading and why you are supposed to be reading, you will have much more motivation to continue reading and finish that book.
Most people who start a book never finish. Don’t be one of those people. Finish what you start and find the time to work on yourself.
Do You Get Faster At Reading The More You Read?
Yes, just like anything else in life, practice makes perfect. When you spend the time to read you will run into words you don’t understand, or you might slip up a couple of words.
As time goes on you will get better and better. Practice will ultimately help you be able to read faster without losing comprehension.
Remember More Of What You Read
Now, this isn’t going to help you read faster directly, but it will help you apply what you learn faster. If you forget what you read in the first place you want to be able to take what you read and apply it to your life.
If this happens it makes the time you spent reading a waste. None of us want this to happen!
This way you can spend less time re-reading trying to figure out what you forgot and more time using the knowledge you gained.
Key Takeaways – How To Read Faster Without Losing Comprehension
Now I want to remind everyone that at the end of the day if you don’t remember anything you read, then there is no point. The whole point of reading is to learn and gain new knowledge. Make sure you are not focusing on the wrong things, do not go through a book as fast as you can. Do not sacrifice speed for comprehension. The goal is to always learn how to read faster without losing comprehension.
All you need to do is to apply these tips to be able to get what you need from these books, in the least amount of time possible. So you can save your time for something else, or even starting a new book.
If you want to learn more about habits and improving your life check out these articles: | <urn:uuid:8a0d6aaa-5def-4da6-b105-3882d81bdce4> | CC-MAIN-2022-33 | https://mindofhabit.com/how-to-read-faster-without-losing-comprehension/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.958256 | 2,101 | 2.296875 | 2 |
Because the glass is cold, when poured into hot water, the glass wall expands rapidly because of thermal expansion and cold shrinkage, but because the glass is a poor conductor if the glass wall is very thick, the temperature of the inner wall can not be quickly transferred to the outer wall, and the inner wall expands and enlarges, while the outer wall keeps its original shape, which will cause the outer wall not to accommodate the expanded inner wall and cause the glass to burst.
Glass cracking is very dangerous, splashing hot water may scald people, and cracked fragments may also cut people, so we need to pay attention to avoid causing the glass to burst in our daily life, so what are the ways to prevent the glass from cracking?
1. To prevent the new glass from cracking, boil the newly bought glass in hot water for ten minutes. After the glass is evenly heated, it will not produce strong pressure and will not cause the glass to break.
2. When pouring boiling water, you can put an iron spoon or stainless steel spoon in the cup, and then slowly pour the boiling water into the cup. So the cup won't burst. This is because when boiling water is poured into the bottom of the cup, it distributes some of the heat to the metal teaspoon of the good conductor before it has time to hot the glass (the bad hot conductor), so the temperature of the boiled water decreases, and it changes from boiling water to hot water, which does nothing to hinder the glass. As for the boiling water that continues to be poured in, it is not so scary for the cup, because the cup is already a little hot in time.
3. Glassware is easy to crack when holding too hot or too cold water, so you should avoid an environment where the temperature difference is too large. Usually, a temperature difference of more than 80 degrees will cause strong thermal expansion and cold shrinkage of utensils, which can easily lead to cracking. Unless otherwise specified, try to avoid using containers to hold water that is too hot or too cold. Before pouring hot water, you can pour a little bit into it, and shake the utensils so that the hot water is in full contact with them, so as to achieve the purpose of preheating the utensils, and then pour in the hot water, which can prevent the utensils from cracking due to excessive temperature difference.
Glass is a non-toxic and harmless appliance for daily use, but we should be careful to use it to avoid some of the dangers that may be caused by its own characteristics. Of course, you can also choose a high boron cup with a higher coefficient of expansion, which will be safer and won't burst easily. | <urn:uuid:4cdd9969-62d5-4df5-9068-8703477e429f> | CC-MAIN-2022-33 | https://www.garboglass.com/news/why-glass-cup-is-dangerous-sometimes-and-how-to-prevent-it-from-bursting.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.935586 | 559 | 3.015625 | 3 |
You can stream today's episode free on TubiTV
Julia hears Morgan calling. She finds him and he says he's Forsythe, and Brutus is here, trying to send him back to the tomb He tells her that she must hear the truth of the curse, and what really happened in 1680. She begs him to tell her. He says that Brutus is here. He shouts that he will tell the truth about the curse. Julia asks how it all began. He explains that he met Brutus in 1677 — introduced by his sister Constance. He says they became business partners, but he found that Brutus was a man of many secrets.
Brutus puts his papers away, and Forsythe enters. Forsythe says he's there to discuss their partnership. He brings up Brutus' strange fixation on the occult. Brutus says he's only a dabbler. Forsythe gets to the point and suggests that Brutus is getting richer while he's getting poorer. He accuses Brutus of stealing from him, and asks to audit the books. Brutus says the books are in the company office. Forsythe suggests that there is a separate set of books. Brutus tells him they will dissolve their partnership in the morning. Forsythe demands what is coming to him, and Brutus assures him that he will get what is coming to him in due time.
Amanda and Forsythe kiss passionately. She says she had to come to see him, and asks what happened between he and Brutus. He tells her that he knows Brutus is embezzling funds. Amanda suggests they check the books in the secret records room. She tells him that she knows where it is.
Constance eavesdrops as Amanda tells Forsythe where he can find the books.
Amanda warns Brutus not to be overconfident. He tells her that he's going to take her away from Brutus. They kiss once more. He arranges to meet her in the morning.
Constance tells Brutus that Amanda went to see Forsythe at the cottage, and they are planning to destroy him.
Forsythe sneaks into Collinwood. Brutus watches him from the shadows as he goes upstairs. Brutus breaks into the secret records room and goes inside. Brutus follows behind him. Inside the secret records room, Forsythe searches for the doctored books. He finds them and says it's worse than he thought. Brutus confronts him. Forsythe says he's going to the authorities. Brutus says he's more ambitious and aggressive than any of his family members. He says that neither his family nor Forsythe will testify against him, and grabbing a stick, he knocks Forsythe out. He says that he left him only one course of action.
Standing over Brutus unconscious body lying on a table, Brutus tells him that he couldn't have known that he would become a victim of his interest in the occult. He adds that an ordinary death would not be good enough for him. He explains that he wants his spirit to be troubled through all eternity.
Amanda goes to meet Forysthe, and when he doesn't show up, she's sure that something is wrong. She runs into Constance, and asks her where Brutus is. She asks if he still intends to end the partnership with Forsythe. Constance tells her that Forsythe left town early this morning. Amanda excuses herself to go to her room.
Amanda goes to the secret records room and finds Forsythe, unconscious on the table. Brutus comes out and points out that the lovers are together. She calls Brutus a murderer. He tells her that he's interested in poetic justice. He tells her that she will now be with Forysthe, and they will be together for a very long time. He chokes her, and says that he will put her body beside his, and her spirit will not rest either.
Constance finds Brutus exiting a door behind his bed. She asks what's behind the door, and he tells her to forget she ever saw it. She says she'll go to find Amanda. He tells her that she left with Forsythe. Constance accuses him of lying to her. She asks what he did to Amanda, and what he did to Forsythe. He tells her to go to her room. She asks if they're behind the door, and before he can stop her, she finds the two dead bodies.
She leaves the room, and Brutus says they deserved to die for betraying him. He warns her not to turn on him. She says she always sided with him against his enemies, but they were right and he's a monster. She grabs a weapon, but he takes it from her and stabs her. She falls on the bed, and places a curse upon the family and future generations. He says it will bring death and insanity to all that inhabit this room. He explains that it shall not end until someone spends the night in the room and retains their sanity.
Forsythe finishes telling the story to Julia (including the parts that he was dead during). She realizes that Brutus cursed his own ancestors. Forsythe hears a noise and says Brutus' spirit is back. Brutus ghost materializes, and commands him to return to his tomb. He chokes and collapses. Brutus assures Julia that the curse will go on, and that the truth will not help her.
|The Petofi box appears again.| | <urn:uuid:9bd4ab7d-4872-4958-a5bc-d9823405773e> | CC-MAIN-2022-33 | http://dsb4idie.blogspot.com/2021/03/dark-shadows-episode-1231-31571.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.986725 | 1,154 | 1.734375 | 2 |
Sound Better at Work or Play!
Within the first seven seconds of hearing your voice, a person will decide if you are trustworthy, smart, effective and interesting.
Is your voice boring?
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Too high or low?
Unpleasant? Indistinct? Not easy to understand? Breathy?
Do you speak too quickly? Sound unnatural? Speak without authority? Lack clarity when you speak?
Voice coaching reveals your most compelling voice. Discover solutions! Find your authentic speaking voice! If you are a singer, learn to blend, sing perfectly in tune, increase your range, sing with clarity, use dynamics with ease or improve your diction. If you are a speaker, learn to connect with your audience, get your message across, speak with passion and clarity, and feel confident.
- Discover your most interesting voice
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- Learn simple and fun exercises for voice and breathing
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- Practice strategies for reducing stage fright and increasing stage presence | <urn:uuid:d44cb6e8-d237-4106-9177-65532b9f7847> | CC-MAIN-2022-33 | https://www.vocaleasecommunications.com/voice/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.889386 | 217 | 2.09375 | 2 |
Picking up the Pacing in Obesity: Medtronic acquires Transneuronix
This article was originally published in Start Up
Medtronic soon will be able to offer a less invasive and safer surgical alternative to gastric bypass surgery, now that it has acquired Transneuronix for $260 million. Transneuronix has developed a gastric pacing device known as Transcend, which stimulates the stomach, and it appears to affect multiple mechanisms in obesity. The device has been approved in Europe, and has been implanted in more than 700 patients worldwide. In the US, Transneuronix has completed enrollment for its pivotal clinical trial.
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Obesity has become an epidemic, with 30% of the U.S. population obese and an additional 35% overweight, including children and adolescents. Bariatric surgical procedures have skyrocketed in recent years, with hospital costs exceeding $1.2 billion, and good success rates. However, for certain groups, such as patients over 65, the risks of bariatric surgery may outweigh the benefits. Much needs to be done to address this troubling and growing public health problem.
According to Medtech Insight’s recently published report, US Markets for Neurostimulation Products, the frontier for neural stimulation is expanding rapidly, representing a $628 million market in 2006 that is forecast to grow by over 20% each year to produce sales approaching $2 billion in 2012. Topics discussed include implantable pulse generators, device reimbursement, and current and emerging applications for neurostimulation. | <urn:uuid:a70116b0-78fd-4898-abfa-20b4c54cbec9> | CC-MAIN-2022-33 | https://medtech.pharmaintelligence.informa.com/MT037375/Picking-up-the-Pacing-in-Obesity-Medtronic-acquires-Transneuronix | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.955947 | 407 | 1.570313 | 2 |
Japan Airlines is now the second airline in the world to operate Boeing's new 787 Dreamliner. The airline took delivery of two of the new composite airplanes this week and plans to quickly put them into service on routes the airliner was designed to fly: non-stop international trips not served by the bigger long-haul aircraft.
One of the first places to benefit from the new airplane will be Boston, MA. The city currently doesn't have any non-stop flights to Japan. Beginning April 22, Japan Airlines will begin the first U.S. 787 route with non-stop flights between Boston and Tokyo. Later this year JAL will also initiate the first non-stop Japanese routes out of San Diego with 787 flights to Tokyo.
Japan's All Nippon Airways took delivery of the first 787s and currently operates them domestically as well as as on flights to Europe. ANA is planning 787 service to both Seattle and San Jose in the next 12 months.
The deliveries of the new airplanes bring a dose of good news for Boeing's new jet which is years behind schedule and continues to have teething issues common to most new airplanes. Earlier in the year the plane maker announced fixes needed for a problem with the fuselage. But beyond small problems with the airplane, one of the bigger issues is how the company will ramp up deliveries to airlines forced to change plans because of production delays.
"It's going to be a difficult process" says aviation analyst Richard Aboulafia of the Teal Group. But he adds without another next generation airliner on the market, Boeing has a little room to breathe. "The best thing you can say is that they don't have anybody nibbling at their heels," says Aboulafia, "The [Airbus] A350 is late as well."
Japan Airlines was forced to push back plans a month for new routes to Moscow, Delhi, and Beijing because of the belated delivery of its 787s, and Air India is looking for hundreds of millions of dollars in compensation. The company is currently building airplanes at a rate of 3.5 per month and hopes to be up to five per month by the end of the year.
At Paine Field, the airport adjacent to the Boeing factory where the 787s are assembled, an unused runway and just about every other open space is currently serving as a parking lot for Dreamliners as they await delivery. There are a few dozen airplanes awaiting changes that were discovered in flight testing after these examples rolled off of the assembly line.
Boeing currently has more than 870 firm orders for the Dreamliner, but just 7 are in service today. JAL is expecting two more 787s next month and Boeing's chief of commercial aircraft Jim Albaugh has said he expects the company to deliver between 35 and 43 this year. | <urn:uuid:dc61b21c-42e6-4d04-82fe-b36f6cfc50f4> | CC-MAIN-2022-33 | https://www.wired.com/2012/03/japan-airlines-opens-new-routes-with-787-deliveries/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.97042 | 577 | 1.546875 | 2 |
I found this story of a girl marrying a water snake in a large book of Russian myths.
One day a young girl was swimming in a lake with a bunch of her friends. When they were tired of their fun they came out of the lake and put their clothes back on, except for the one girl who found a snake laying on her outfit. She begged him to go but instead he bargained with her. He said that if she agreed to marry him she could have her clothes back. Her friends told her to go ahead, after all who could marry a snake? So she accepted the snake's proposal and he left.
Later, the girl told her mother what had happened. “Do not worry”, her mother said, “who can marry a snake?” Several days later, a large group of snakes appeared and forced their way into the house. They took the young girl and dragged her back to the lake. Once underwater the snakes turned into people, and the girl was married to the snake.
After some years, the girl asked to visit her mother and her husband agreed. He took her and their children to the surface and said, "When you wish to return, come to the lake and call 'Joseph, Joseph, come and fetch me.'"
The girl brought her children to her mother's house and had a friendly visit. She told her mother that her life in the lake was very pleasant, better even than her mother's. During the visit, her mother asked how she was to get back to her husband. The daughter explained little knowing what her mother was planning.
That night while the girl slept, her mother sharpened an ax and went to the lake. Once there she called, "'Joseph, Joseph, come and fetch me." When the snake appeared she cut off his head. Of course, she did not tell her daughter about this.
The next day, when the girl returned to the lake and called, her husband did not appear. After a time she found a head floating in the water and realized what had happened.
"My mother has killed him," she said.
Using the magic she had learned from the snake people, she turned herself and her children into birds. | <urn:uuid:67b4e2db-b156-4ed4-9184-709fbbe592a9> | CC-MAIN-2022-33 | https://www.beautiful-mermaid-art.com/russian-myths.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.995208 | 454 | 1.914063 | 2 |
Everyone is talking about Hamilton thanks to its recent release on Disney+, and the conversation surrounding Lin-Manuel Miranda’s blockbuster musical hasn't been limited to just the reactions to its content. The filmed production with the original cast, taken from several performances back in 2016, has stirred up a lot of chatter regarding what business the production could have done if it had hit theaters instead of streaming, and, as will be explored in this feature, the debate of whether or not it should be considered eligible for Academy Awards.
Needless to say, there’s a bit of a divide on the latter matter, even amongst our own ranks at CinemaBlend. In the spirit of Hamilton, we’ve opted to duel over the subject of whether this film should be eligible or not. The big difference, of course, is that instead of pistols being drawn, we’ll be using arguments that take into account the Academy’s rules for what qualifies as a valid entry into the Oscars race (thanks to details published by Variety). Starting us off and definitely not taking aim at the sky is Eric Eisenberg, arguing against Hamilton being considered for Oscar recognition.
Why Hamilton Shouldn't Be Eligible For The Oscars
Putting aside various issues and systemic problems, the Academy Awards is about one thing: the celebration of film. All genres are taken into consideration, as are documentaries and shorts, and the art is highlighted on a great number of levels – from visual effects and production design, to scripts and direction. There are rules regarding length, distribution, and other details, but it’s a fairly open contest within the medium.
All that being said, there’s a simple explanation as to why Hamilton shouldn’t be taken into consideration for the Oscars: it’s not a film; it’s a taping.
When Lin-Manuel Miranda first set out to write his hip-hop-heavy historical musical, one of the first choices that he had to make was to choose a medium, and the medium he chose was theater. This was a key decision that impacted nearly everything about the production from that point forward, from its structure (a two act story that uses an intermission to separate pre- and post-revolutionary periods) to its presentation (such as the rotating segments of the stage, and the spotlight moments for Jonathan Groff’s King George III).
That work culminated as the show witnessed by thousands live as it was staged on Broadway, and the musical that is now available to stream for Disney+ subscribers. And that’s the point. While the edit uses material from multiple performances, the content of the creation itself was not changed in any way to fit a new medium. Something doesn’t just become a film because you point a camera at it. By that logic, the Oscars would need to start looking at recorded sporting events, stand-up comedy specials, and Fathom Events opera presentations too.
Had Lin-Manuel Miranda adapted what he created for the stage in Hamilton this would be a completely different conversation, but that’s not what happened. It may feature multiple camera angles and a variety of cuts, but it’s not a film, and rightfully shouldn’t be taken into consideration by the Academy.
And now, to rebut this argument, is Mike Reyes, who is on the side of Hamilton being considered for Academy Award recognition:
Why Hamilton Should Be Eligible
If Hamilton was merely a recording of the original Broadway cast, I’d be more inclined to agree that it’s just a “recording of a performance” and leave it at that. But the way that the show was filmed and edited, especially the usage of audience-free performances of certain moments for close ups, convinces me that at the very least, the film should be considered in the Best Documentary Film category. However, I would even go as far as saying that with all of the time, effort, and thought that went into staging and capturing the Hamilton performances we see in the Disney+ version of the show, a Best Picture nod wouldn’t be a possibility out of the question either.
I wouldn’t go as far as saying the film would be eligible for nominations pertaining to set design, costuming, or any other pre-existing component that was designed for the Broadways how. But at the very least, the product of the film itself deserves to be honored; especially in a year where there may not be too much content eligible in the traditional sense to begin with. Hamilton is a filmed experience that takes the Broadway musical, and translates it into a cinematic journey. At the very least, it should be considered as an awards contender in that respect.
There you have it! Two sides have come to the table to debate whether or not Hamilton belongs in the running for Oscars gold or not. However, don’t take that as a sign that the matter is closed and done. Now it’s time for you, the reading audience, to tell us what you think. Should Hamilton qualify as an Academy Award contender, or do you think that it’s not playing by the rules?
Let us know what your feelings are in the matter through a vote in our poll below. Also, don’t forget to hit the comments section with your expanded thoughts on why you feel one way or another on the subject. Meanwhile, Hamilton is currently available to stream on Disney+; but you may have already known that.
This poll is no longer available.
NJ native who calls LA home; lives in a Dreamatorium. A decade-plus CinemaBlend veteran; endlessly enthusiastic about the career he’s dreamt of since seventh grade.
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There was a problem. Please refresh the page and try again. | <urn:uuid:50b103f1-04da-47e8-8da8-8ab9a976ea0e> | CC-MAIN-2022-33 | https://www.cinemablend.com/news/2549877/should-hamilton-be-eligible-for-oscars-weve-got-thoughts | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.959568 | 1,220 | 1.65625 | 2 |
The delivery of proper healthcare services in Guyana has languished over the years and is the story of “Two Guyanas” where rural areas (where mainly PPP supporters live) were neglected and you had to travel to town to get better treatment and services. The drug bond scandal under the PNC/AFC reflects corruption in the health sector, including the theft of drugs and medical supplies by staff, depriving the system of vital resources. Lack of trained doctors/nurses/specialists (e.g. no trained ultrasound technicians at Suddie Hospital for five months), drug supply issues, poor inventory control systems, need to destroy drugs due to a high expiry rate, have impoverished the health care system. (See “Government Begins Dumping Over $742 Million in Expired Medicines Left Behind by Coalition,” KN, November 21, 2020). If you didn’t have the money to go to a private hospital, you might die in the government facility.
Thus, the government is to be commended for its plan to build seven new hospitals. The PNC/AFC, playing politics, had thwarted the PPP project to build a specialized hospital. The urgency of a decent healthcare system may not have been a priority for politicians because they can access foreign treatment at taxpayer expense. A Mr. David recently wrote: “Guyana is a fractured health system in need of major surgery. Try to summon an ambulance, ambulance or emergency medical transport (EMT) to take a sick, injured or disabled person to the hospital and you will find the futility of your efforts. Our experiences in Region 6 provide insight into how poorly our system works. At health centers – poorly maintained and the grass not mowed – you get few services and are usually referred to a real hospital. If you go to Black Bush Hospital they can refer you to Port Mourant Hospital which has been a joke for a long time as it was a decrepit, poorly equipped and poorly maintained facility that offers very few services. Whether you go to Black Bush Hospital, Port Mourant or Skeldon, you will eventually end up in New Amsterdam Hospital and then you may be referred to Georgetown Hospital.
You can die in this carousel. For a rural person, having to travel to Georgetown to access treatment is traumatic as it takes time, you are unfamiliar with the town, and travel and accommodation will be difficult and expensive. Rural people pay more for everything, compared to city/region residents 4. Those with lots of money can access the private Anamayah Hospital in Belvedere. When people go to clinics and hospitals, it often happens that the drugs are still not available, and you are given a prescription to pick them up and buy them yourself. My friend George told me he had blood tests done and after a month his clinic said they had not received the results. What I find very sad is when parents have to make appeals in the newspapers for financial assistance to get life-saving treatment abroad for their children. This should not happen when we are the richest country in CARICOM (but our currency is less than Haiti’s), when the government allows oil companies to take most of our oil wealth. People need to understand that if we don’t renegotiate the oil contract to get more money, it will be a long time before we see widespread improvements in our lifetime.
The announcements of many new hotels do nothing for the poor in the villages. I noticed that the government is in partnership with Hess and Mount Sinai. We need more disclosures on this arrangement. Make the documents available on the website. While the United States has good technical facilities and services, health care is the biggest rip-off there. Their “for-profit” system is designed to scam consumers. Health care and medicines are very expensive and can put you out of business. The medical lobby is the most powerful. Republicans are good at convincing their constituents that universal (free) health care is bad for you. The first thing a medical professional wants to know is if you have medical insurance. In Dubai/UAE, an employer bringing in workers must provide health insurance as a condition for a work permit to be issued. With foreigners coming to work in Guyana, do we have such a rule? We need to watch the growing trend to privatize health care. Which friends of the government will benefit? We must expand universal health care.
We need dialysis clinics everywhere, in every region, and should have more than one such facility in large regions such as region 6. We need laboratory services, including all diagnostic imaging, MRI, ultrasound , X-rays, scanners, occupational therapy and physiotherapy in the areas where we live. The government needs to stop putting everything in New Amsterdam. We need equal services in Upper Corentyne, Central Corentyne and New Amsterdam. What is the government’s plan for the current Skeldon Hospital? Why can’t we upgrade and modernize Port Mourant Hospital which is at the heart of a large population area, also a PPP vote farm? How about adding an American-style “urgent care” component to some community health centers? The government is on the right track with the seven new hospitals, but much remains to be done and should be accelerated. Renegotiate oil contracts so we can get more money to do all these things. Everything needs to be improved!
Dr. Jerry Jailall | <urn:uuid:8e80cc72-4c3e-490d-b93d-281d20cff7a8> | CC-MAIN-2022-33 | https://basketvillageusa.com/government-health-program-lacks-equity-in-rural-areas/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.966507 | 1,119 | 1.742188 | 2 |
The U.S. likely is producing enough masks, gowns, and other personal protective equipment. The supplies just aren’t getting to all the health-care workers who need them.
Federal funding and real-time data sharing have helped manufacturers boost domestic production of gear seen as critical for essential workers during the pandemic. But without a national, centralized database to track supply and demand—particularly who needs what and where—many of those workers will continue to go without, lawmakers and policy consultants say.
“We never actually identified how much we need as a country and how much we have as a country,” Rep. Andy Kim (D-N.J.), a member of the House Select Subcommittee on the Coronavirus Crisis, told Bloomberg Law. It’s difficult to know if the federal government is doing enough if that wasn’t accounted for, he said.
Health-care workers still don’t have access to adequate PPE, although the situation has vastly improved since the beginning of the pandemic. The issues that manufacturers have worked through to make sure inventory is robust show the increasing complexity of the medical supply chain in the U.S. health-care system.
But they also show that production levels likely aren’t the cause of continued supply shortages throughout the country.
There is no comprehensive data about what PPE is needed or who needs it on a national level, which makes it impossible to inform equitable distribution, said Megan Ranney, co-founder of Get Us PPE, an organization that provides PPE to communities in need at no cost.
The government has launched a platform to track health-care equipment production and is creating a second one on hospital needs. But those moves don’t cover PPE for the entire health-care system.
The federal government also doesn’t release any information publicly about how much PPE health-care facilities need. However, Get Us PPE says it has received 16,800 requests since March, totaling at least 22 million pieces of PPE. In October 92% of the requests came from non-hospital facilities, including nursing homes, dental clinics, and homeless shelters.
Ranney, an emergency physician at Brown University, said it’s possible the national stockpile isn’t getting many requests because it’s not clear who can ask for supplies or what metrics the government uses for assessing and fulfilling those requests.
As of Dec. 4, the national stockpile had 164 million N95 masks, 201 million surgical and procedural masks, 84 million gowns and coveralls, 65 million gloves, and 23.5 million goggles and face shields, according to an HHS spokesperson. States are building up their own stockpiles, and 90% have at least 30 days of supplies, Brig. Gen. David Sanford, director of the Trump administration’s Supply Chain Advisory Group, told reporters Dec. 10. The national stockpile is set to have 190 million gloves by the end of the week, Sanford said.
The administration has been working to stockpile 90 days supply based on peak Covid-19 infections, but it’s not clear if that amount includes supplies for doctor’s offices, home health workers, teachers, and other parts of the community, Kim said.
“We’re no doubt in a better place” with the PPE supply, Kim said, but “what is the metric by which we’re calculating what that need is?”
A “supply chain IT control tower” launched by the Trump administration tracks health-care equipment makers and distributors and includes data on production capacity, forecast demand, and target distribution. The administration is also gearing up to launch a “health-care resilience control tower” that tracks hospitals’ staffing and equipment needs and alerts the government when facilities are running low.
However, this second platform will initially only include hospitals and not smaller facilities like dialysis centers or physician practices. And without information from the entire health-care system, the database is incomplete, consultants say.
Everyone should have a list of the places where supplies are needed for workers at that moment, said Nicolette Louissaint, executive director and president of Healthcare Ready, a nonprofit that focuses on health-care supply chain preparedness. States and companies need to be able to identify where the true need for PPE is to get supplies to workers, she said.
There’s likely enough supply for the current demand from hospitals, Ranney said, but that doesn’t allow for PPE as a single-use product—the traditional way it’s been used. And that demand doesn’t typically include providers who don’t work in hospitals, like school nurses and home health aides.
In addition, many manufacturers are requiring PPE be purchased in large volumes or with cash already on hand, which makes it unavailable to smaller groups of health-care providers, Ranney said.
A more broadly available data set about providers lacking PPE could allow those smaller groups to get supplies when needed.
Ranney said all health-care facilities should have to include information about their PPE supplies as part of the data they already submit to the Department of Health and Human Services. Hospitals are required to submit weekly data to the Centers for Disease Control and Prevention on how much PPE they have, if they can order more, and if they’re reusing it.
She also said the federal government should invest in work to coordinate the manufacturing and distribution of both bought and donated PPE, either done by other entities or the government itself.
Manufacturers started using real-time PPE usage data in an effort to increase supply during the pandemic—a shift from previous production models that relied on past usage.
In addition, financial investment from the federal government and some states has increased private sector manufacturing and helped provide assurance to companies that they won’t lose money.
The Trump administration used the Defense Production Act to invest in five N95 manufacturers—including
But industry is still concerned about how long the financial support will last, Kim said. Longer-term, sustained investments from governments would have helped create more certainty for the industry, he said.
The Indiana Economic Development Corporation, a public-private economic agency, guaranteed companies it would buy their supply until a set time, said Luke Bosso, the agency’s senior vice president and chief of staff. Companies then had the option of entering into an agreement where the state would continue to buy their supplies going forward.
“We’ve tried to take as much risk out of our purchases as possible,” Bosso said, so the companies know they will get paid if they continue to make PPE.
States and health-care facilities are also better prepared to handle supply shortages going into the winter, both due to stockpiling and increased cooperation.
Louissaint said the turnaround in the supply of PPE wasn’t a single event, but a “dedicated, concerted effort to work together to share information about what was available, what could be available.”
The replenishment of the national stockpile, facilities keeping more supplies on hand, and health-care workers using conservation practices helped contribute as well, Louissaint said. Conservation practices, like reusing N95s, allowed product availability to increase but has also put workers’ safety at risk.
There are good indicators that the U.S. is in a better position, said Chaun Powell, group vice president of strategic supplier engagement at hospital supply-purchasing group Premier Inc.
But the stockpiles are just a band-aid on the PPE supply chain, he said. Even with the improvement in manufacturing, it doesn’t help if health-care workers can’t get the supplies they need.
Just the U.S.
Unlike most other wealthy nations, U.S. shortages of PPE have persisted throughout the pandemic. Despite some moments of reprieve in cases, the supply chain hasn’t been able to catch up to how much is needed.
Doctors and nurses are still reusing their PPE, at points were using trash bags as gowns, and organizations are still purchasing supplies from untrustworthy suppliers.
A September study found that an N95 can be decontaminated and reused up to three times, but 58% of nurses surveyed by the American Nurses Association said they were reusing single-use PPE like an N95 mask for five or more days. Another study found masks began failing around the third and fourth use.
About 1,700 U.S. health-care workers have died from Covid-19 and related complications, according to a September National Nurses United report.
“Many other countries experienced very short-term shortages of PPE in the early days of the pandemic when every country was trying to purchase,” but those ended, Ranney said.
Italy, for example, had PPE shortages and used “extreme measures of conservation,” Louissaint said, but their surge in cases decreased “fairly quickly.”
The way each country’s health system buys and distributes PPE also affected whether they struggled to get it. The U.K.’s National Health System buys PPE for all health-care facilities and distributes it to them.
The U.S. has a “fragmented procurement strategy” because each state operates on its own, Louissaint said. A unified strategy allows for streamlining and a better understanding of real need rather than anticipated, which makes purchasing easier to control, she said. | <urn:uuid:efe959a7-7733-4c29-9b0b-582b7633fc82> | CC-MAIN-2022-33 | https://news.bloomberglaw.com/health-law-and-business/getting-ppe-to-frontline-workers-in-need-is-a-national-struggle?context=search&index=6 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.965919 | 2,009 | 2.1875 | 2 |
The facade of any building is its architectural attire, an external cover. And the first impression of the house depends on from what it will be. Certainly, the chosen way of finishing of an exterior of a private household reflects flavoring preferences, a favorite color palette and even a way of life of owners. But, planning appearance of a facade of the house it is important to remember not only external appeal of finishing materials, but also a functional component. Best House Elevation Design finishing must be protected from moisture and to be resistant to emergence of corrosion, to maintain frosts and to quietly transfer active sunshine that warms the building and to be non-toxical, not to do harm to health of house owners and state of environment.
Choosing style for a building exterior, it is important to consider several components: features of climate and the surrounding nature, territorial specifics of location of the house, appearance of the neighboring buildings and your desire to merge with the general stop or to be allocated on the contrary from the lump of private houses.
Deciding on style of a facade, it is necessary to remember that the design is a flight of fancy and canons therefore the majority of the houses which are made out today have in the designs and ways of finishing mixture at least of two stylistic directions, and sometimes and more are alien to it.
Speaking about the private households located in city boundaries or near it, then the tendency of industrialization of an exterior of buildings was outlined recently. Best House Elevation Design
is the minimalism. Combining in itself current elements hi-tech became more and more popular among house owners and designers
As a rule, houses in minimalist stylistics are simple from the point of view of geometry and finishing of a facade. Accurate forms, simplicity and laconicism – the main concept of modern buildings.
Even using of the natural materials, or their artificial analogs, for finishing of private houses in a case with minimalist design does not allow us for a second to doubt in the general style of a household.
Whether it is difficult at first sight to define inhabited this building or industrial, often only sizes and landscaping of the private yard indicate presence of house owners.
At registration of houses in minimalist style light color scale is often used. It is connected with the fact that the big areas nothing not diluted surfaces of modern buildings rather hard looked in a dark palette of paints. | <urn:uuid:4728177d-8b49-4f2d-bd17-714403e22071> | CC-MAIN-2022-33 | http://design.daddygif.com/best-house-elevation-design/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570793.14/warc/CC-MAIN-20220808092125-20220808122125-00672.warc.gz | en | 0.958671 | 488 | 2.078125 | 2 |
Increasing your visibility when cycling on busy roads at night is always advisable and the Arclight illuminated LED bike pedals provide an easy way to add 57% more visibility to your bike say its creators. Using bio-motion technology and modular lights that automatically turn on and off as you start pedaling to conserve battery power. The Arclight rugged waterproof bicycle pedals is currently in its final days on Kickstarter and has already raised more than $300,000 thanks to nearly 3,000 backers.
Increase your visibility while riding with LED bike pedals
Backer early bird pledges are now available for the unique project from roughly $29 or £39 (depending on current exchange rates), offering a considerable discount of approximately 31% off the final retail price, while the Kickstarter crowd funding is under way.
“The unmistakable circular movement of the Arclight Pedals attracts the attention of motorists and pedestrians – instantly identifying you as a cyclist. Scientific studies performed by Clemson University and others show that adding bio-motion (motion that is associated with the natural movement of the human body) increases visibility by up to 57% compared to standard front/rear lights.”
If the Arclight campaign successfully raises its required pledge goal and the project completion progresses smoothly, worldwide shipping is expected to take place sometime around February 2022. To learn more about the Arclight illuminated bike pedals project checkout the promotional video below.
“Standard bike lights are often difficult to distinguish from car lights, traffic lights, and building lights. The dynamic motion of the Arclight Pedals creates a unique visual signature, cutting through the visual clutter to maximize visibility and safety. Standard bike lights are typically visible only from directly behind or in front of the bicycle; with limited visibility from the sides. The wraparound design of the Arclight LED modules illuminates every angle – providing 360° of protection.”
“Staying visible is the best way to keep yourself safe on the bike. The Arclight Pedals amplify your biological motion making you up to 57% more visible than standard bike lights. Powerful LEDs and long lasting rechargeable batteries ensure you will stand out and stay safe even on your longest ride. Arclight’s SmartSet sensors turn the lights on automatically when you start riding, and turn off automatically when you park your bike. They’re on when you need them and off when you don’t.”
For a complete list of all available early bird specials, stretch goals, extra media and technical specifications for the illuminated bike pedals, jump over to the official Arclight crowd funding campaign page by following the link below.
Source : Kickstarter | <urn:uuid:e686ac1d-1a5a-4e75-b697-71a8a22e7fa4> | CC-MAIN-2022-33 | https://www.geeky-gadgets.com/arclight-illuminated-bike-pedals-10-10-2021/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.922852 | 543 | 1.796875 | 2 |
Nonagenarian Margaret Keenan became the first person in a Western nation to receive a COVID-19 vaccine out of a clinical trial setting on Tuesday morning, after the UK became the first country to approve and begin rolling out the Pfizer/BioNTech vaccine.
Keenan, who turns 91 next week, was given the first of two vaccine doses at her local hospital in Coventry, England. “I feel so privileged to be the first person vaccinated against COVID-19, it’s the best early birthday present I could wish for because it means I can finally look forward to spending time with my family and friends in the New Year after being on my own for most of the year,” she said.
Keenan added, “I can’t thank May and the NHS staff enough who have looked after me tremendously, and my advice to anyone offered the vaccine is to take it—if I can have it at 90 then you can have it too!”
More From Town & Country
After Keenan, a small group of other people across Britain also received a first dose—including the second person to receive the vaccine, an 81-year-old man named William Shakespeare (yes, really). At this point, the vaccine is mostly being distributed to key groups of people, including those over 80, nursing home workers, and healthcare professionals.
The Pfizer/BioNTech vaccine is currently still under review with the European Union and the United States. Dr. Anthony Fauci recently explained that the FDA does "things a bit more differently" than UK regulators, walking back a previous statement that the UK "did not do it as carefully and they got a couple of days ahead," after coming under fire for "vaccine nationalism." | <urn:uuid:dff49c63-c5ab-4b47-89a9-3fb5c2fd3927> | CC-MAIN-2022-33 | https://www.townandcountrymag.com/society/a34904879/covid-19-vaccine-first-recipients-uk/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.97212 | 364 | 2.03125 | 2 |
After receiving a DIY mason jar snow globe from my daughter last year, I was inspired to make a snow globe ornament!
The good news?
Our snow globe ornament came together in minutes with just a few simple steps. The better news? It goes along with a sweet children’s book that you’ll love reading to your kids too…
This post contains affiliate links to Amazon so you can see exactly what I used!
After reading the book, the Snow Globe Family, I quite literally wanted to put my family in a snow globe…
But since they didn’t fit. This snow globe ornament was the next best thing.
Here’s What You Need to Make a Snow Globe Ornament
- Clear plastic ornaments like these. They need to be able to open. I bought 3 different sizes at Michael’s and used the medium size.
- Fake Snow.
- A Photograph that’s printed to the size of the ornament (I used use a medium sized ornament with a 3inch diameter. So, we printed our photo a custom size of 3×4 inches).
- Mason jar lids for the backing the ornament.
- Glue gun (I use a mini).
- Optional: ribbon.
How to Make a Snow Globe Ornament
Start by printing out your photo. I printed mine a custom size of 3x4inches because my ornament is 3inches in diameter.
Place half of your plastic ornament over the photo and trace a circle around your photo.
Cut the circle out with scissors.
After you’ve cut out your photo, plug in your hot glue gun.
Glue the photo to the mason jar lid.
Watch your fingers!
The glue will be hot through the photograph, so I used the ornament to push the photo down onto the mason jar lid.
Once you’ve glued the photo to the mason jar lid, turn your ornament upside down.
Put just a little bit of fake snow into the ornament.
Then, trace the top of the ornament with glue and place your mason jar on top to glue the lid and the ornament together.
Watch your fingers AGAIN – it’s hot!
To finish the ornament, you can trace glue along the base and add a ribbon.
We used the ribbon as a way to hang the ornament on the tree.
Of course, you can always just thread some ribbon through the ornament hole and call it a day!
PS. Let your kids shake the ornament to get that snow globe effect!
Don’t forget to read The Snow Globe Family while you make this ornament. It’s a sweet story of a forgotten snow globe family that finally gets noticed by the family’s baby…
Kids will love snuggling up with some cocoa while reading this children’s book with you.
Don’t forget to check out the rest of the crew in the blog hop today!
My favorite part of the year is when a bunch of kid bloggers get together to share DIY ornaments along with their favorite children’s book.
I *almost* missed the kid-made ornament blog hop this year because I have a sweet, coo-ing newborn at home, but I’m so glad to be here again this year!
More Blog Hop Posts:
Katie the Candy Cane Fairy Book-inspired Ornament Craft | Artsy Momma
Mini Christmas Letter Ornament | Mama.Papa.Bubba.
MADELINE EIFFEL TOWER CRAFT | Kitchen Counter Chronicles
Spin Art Candy Cane Ornament for Kids | Handmade Kids Art
More Ornament Ideas from Happily Ever Mom | <urn:uuid:6b88eef3-2404-4dc0-a860-dbe320c57556> | CC-MAIN-2022-33 | https://happilyevermom.com/make-a-snow-globe-ornament/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.857774 | 782 | 1.835938 | 2 |
i. Payback period:
The advantage of the payback period:
To some degree, we can say that the shorter the payback period, the less risk the investment is. So the measurement of the payback period takes into account of the risk of the investment. In addition, with the shorter payback period, you can recover your initial investment and can use your money to invest on other new projects. So it can help the company seek profitable investment opportunities in the changing market.
The disadvantages of the payback period:
It does not take into account of the time value of the money. It gives the equal weight to all the cash flow occurred in different time. With a greater inflation, the payback period may bring companies great loss.
The factor of the investment size is not included in the payback period. Even though a project has a short payback period, it may have a very small profit. In contrast, another project, with a big investment size and a relatively long payback period, is very profitable.
The payback period does not give attention to the term structure. With the same payback period, two different projects may have dramatic lad in profitability.
When to use payback period:
According what mentioned above, it is better use payback period to make investment decisions when all the projects have no difference on other items and when the investor gives much importance to the recovery time.
ii. The analysis of the IRR:
The merit of this measurement is taking into account of the time value of the money and the term structure of the cash flow. It has strong links with NPV. We can easily see this correlation from its definition. NPV is an absolute value, but IRR is a relative value. So it can better reflect the efficiency of the | <urn:uuid:48095b75-af18-4465-a264-07426fa7ad01> | CC-MAIN-2022-33 | https://www.studymode.com/essays/Strenght-And-Weaknesses-801170.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.931117 | 367 | 2.953125 | 3 |
What Are The Benefits Of Using Our Services?
Are You An Innate Entrepreneur
Let’s have a quick checklist, shall we? In this post, we will try to assess if you are an innate entrepreneur. But this doesn’t mean that if you do not qualify according to our questionnaire is that you cannot have your own business. This is just a reference if you have what it takes to be a business person. You can also use this if you wish to improve yourself.
It’s Ok To Be On Your Ownsites similar service to no need to study
As an entrepreneur, it is not important to be with a social group. In fact, there will be a lot of times that you need to isolate yourself to think of the best plans for your business. If you’re OK with this, then that’s a good start or a good sign that you can become a business person or entrepreneur.
You Are Ambitious
Another sign that you can be a good entrepreneur is if you have big goals or sometimes, crazy ambitions. More often than not, successful businessmen have been unrealistic goals in life. And because of that, they persevere, and they try to do everything that they could to reach those ambitions and goals. If you’re up for the challenge, then we say go ahead and start building your business.
You Love To Read And Love To Learnpayed someone to take my online class
Do you always want to learn new concepts? Are you always updated with industry news? Or are you always fond of reading anything under the sun? If yes, then that’s another sign that you can be a good entrepreneur. As they say, successful people would always read a lot of books, and they are always open to embarking on new knowledge. That way they could create the best practices once they establish their own venture.
You Know How To Use Your Time Wisely
Quite frankly, we know a lot of students who would rather watch Netflix all day long or over the weekend. But what sets entrepreneurs apart is that they know how to manage their time wisely. Instead of doing practically nothing, they will try to be more productive. They will create plans, or perhaps attend online courses as much as they can. They don’t want idle time on their hands, and they want something to get out of what they are currently doing.
You Are Not Afraid To Leave Your Comfort Zone
For some reason, most entrepreneurs are always ready to go out of their comfort zones. They don’t care if they feel uncomfortable, as long as they get something out of it, or they learn something from it. If you are that type of person, then we say leverage on that. Not all people are like you, and that should serve as your advantage.
You Are Not Afraid To Fail
Apart from not minding if you are uncomfortable or not, entrepreneurs are not afraid to fail. If you must know, a lot of successful people encountered several failures in their lives before they were able to experience triumph. They don’t quit. But instead, they use these so-called failures as steppingstones to reach their goals.
You Love To Solve Problems
If you love to solve problems, then that’s another amazing sign that you could be an entrepreneur. Just so you know, establishing a business can have a lot of challenges along the way. And if you are not up to solving these issues, then perhaps this path isn’t for you.
You Can Work Practically Anywhere
Most entrepreneurs that we know do not have a specific place where they need to work. It’s as if the whole world is their office. They try to get ideas from different places and different people. They observe, and they use these learnings to establish their brand.
You Love Seeking For New Opportunities
An entrepreneur or businessman would love to look for different opportunities, whatever it may be. For example, if there is a demand, they would immediately look at the products and supplies that could address that need Or, for example, there are services which are not yet provided to a specific market, they would create a plan on how they can sell it to the same people.
Still Got Questions?
We got the Answers!
Real Customer Reviews | <urn:uuid:869e1d82-d5c2-4e5e-8cd4-3ccc02b85efc> | CC-MAIN-2022-33 | https://paysomeonetodo.com/are-you-an-innate-entrepreneur | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.96494 | 888 | 1.742188 | 2 |
Have you ever wondered how your personality shapes the way you interact with other people? Do you prefer quiet time alone or interacting with a lot of people? Do you like to be highly organized or fly by the seat of your pants? This interactive workshop will help you learn not only about your own behaviors and preferences but also how people with different personality types might perceive those behaviors and preferences, impacting your effectiveness as a leader. Using an assessment based on the Myers-Briggs Type Indicator, this workshop, facilitated by Shelly Hoover-Plonk, Ed.D., will help you apply your understanding to your interactions with others.
The registration deadline for this workshop has passed.
Detailed instructions for the assessment available upon registration; all participants must register and complete the assessment by Friday, May 20 at 5 p.m. This workshop is open only to current graduate students and postdocs.
Lunch will be served; please bring your own beverage to enjoy.
LocationRubenstein Library 153 Map and Directions
- Professional Development | <urn:uuid:35fc64d1-ba64-41cc-a2ae-a77b446d7c38> | CC-MAIN-2022-33 | https://gradschool.duke.edu/student-life/events/how-do-you-lead-people-who-are-not-you-myers-briggs-and-leadership | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.929201 | 210 | 1.976563 | 2 |
Many of our blog postings have something to do with data security in one form or another. The reason is because today’s world is different than the world was five years ago. If you have not changed the way you are securing your critical data and systems over that time, your measures are likely no longer sufficient. Threats like ransomware present significant risks to businesses today. Did you know your business could get fined by the FTC if your business becomes the victim of ransomware? Here are some of the top mistakes we see being made in regards to security:
- Using the same passwords for different uses
We are still seeing the repercussions from the LinkedIn hack a few years ago. If you were notified about the hack and just changed your LinkedIn password, you may not have done enough. The hackers had a list of emails and passwords from the hack and then tried those same credentials at different sites. “Let’s see if those credentials work on Facebook…..or Chase bank perhaps.” If you are using the same password for multiple applications you are at risk if one of those sites is compromised.
- Not keeping employees up-to-date on security threats
As we mentioned in the introduction, the world is changing and new security threats are out there such as ransomware, scareware and social engineering scams. Are your employees or coworkers up to speed on the threats they might face? Do they know how to react if they encounter one? Awareness training is a key component to a comprehensive security plan.
- Not using web browsing controls
Web browsing controls, sometimes called content filtering, used to be considered an optional item for businesses. In today’s environment, we consider it a necessity. A good content filter will block known bad sites to prevent users from accidentally (or purposefully) going to site that can infect their business computer. There are many forms of malware that attack through web browsers. You should have the mindset that when you are using a web browser, you are in the danger zone. Web browsing involves connecting to other computers that your organization does not control and must trust.
- Failing to review security policy and protective measures regularly
This is how businesses fall behind the curve with security. Systems are put in place and the security of those systems are never regularly reviewed to see if they are keeping up with the evolving security threats they might face. Who is responsible for this in your organization?
These are just a few of the mistakes we see businesses making. The result is that your business is put at risk. Are you making any of these mistakes? Contact us at Colden Company and see how we can help remediate these issues for you and protect your critical data and systems. Call us at 888-600-4560, email us, or visit us on Facebook or Twitter. | <urn:uuid:6ea9927f-feb2-4732-a6fa-30ac51e82f6c> | CC-MAIN-2022-33 | https://www.coldencompany.com/security-mistakes-businesses-make/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.960128 | 566 | 2.46875 | 2 |
Presented by Blackberry
What's the future of mobile gaming?
As much as mobile technology has advanced in the last five years, the evolution and revolution of the next five years is going to be even more drastic. Who would have thought that today we'd have cellular data connections that outstrip most hardwired home connections, or screens with pixels so small we can't discern them with the naked eye? Or that we'd be cramming all of this into phones a quarter of an inch thick?
Five years ago the best games we had were basic racers, two-dimensional strategy games, and variations on board and card games. Today when you fire up your app store there are graphically-rich racers, intense shooters, interactive puzzles, physics engines put to work powering animated slingshots, and so much more.
Just what does the future hold in store for mobile gaming?
Let's get the conversation started!
- On a quest for the virtual reality Holy Grail
- 3D, and how execution matters
- Approaching critical mass for motion control gaming
- New hardware begets new gaming experiences
However, another popular sci-fi mainstay, the virtual reality headset, could be a lot closer. We don't need to paint a room or fake out our brains if we can cover our field of vision and dazzle our eyes. Sure, it's not the same, but one-to-one tracking strapped to our faces is far closer to a reality than anything Jean-Luc Picard or Neo get to experience.
In fact, it's almost here already in products like the Oculus Rift, which we've seen demonstrated at the Consumer Electronics Show and Game Developers Conference. It's a project bordering on a product, but if you've ever tried it, or ever seen someone try it...
The technology disappears and all that's left is the experience
You look out. You look up. You see snowflakes. You reach for them. In that moment, the technology disappears and all that's left is the experience. It's transformative.
Perhaps Google Glass is heading that way as well, and who knows what Apple, Microsoft, and BlackBerry, and companies like Nvidia, and small startups we've yet to hear about, are working on deep in their vaults.
One day we might just put on a pair of glasses, link to our mobiles, and see games explode across our virtual horizons. Everything from first person shooters to casual puzzlers could be amazingly, experientially, virtually real.
It certainly won't be practical all the time, or even most of the time, but for immersive gaming, for when we want to turn on and truly tune out, when we want to explore worlds other than our own, for the first time it'll be a possibility. And it'll be sooner rather than later.
I want it now.
Is there anyone out there who doesn't think 3D on phones and tablets was a failure? There are folks out there who love their 3D phone, of course, but fortunately that idea died out after a couple of tries in 2011. HTC's EVO 3D on Sprint failed to catch on, as did the LG Optimus 3D and the dozen other 3D smartphones built by smaller manufacturers.
That's not to say that trying 3D was a bad idea. The mobile space needs more innovation, not less. And that includes the occasional crackpot idea that might be so crazy it works. (It can't be coincidence, however, that more than one manufacturer decided to try 3D devices at roughly the same time, right?) 3D was one of those. Television manufacturers were aggressively pushing it -- so why not mobile?
The mobile space needs more innovation, not less
The problem with 3D was twofold. First and foremost, not everyone can stand the tech. For as good as it was -- and it wasn't necessarily horrible -- it definitely could be hard on the eyes. Nature just didn't build us to focus and converge on different planes, and if there's one place you need less eyestrain, it's on your phone.
The other factor was 3D content. What good is a 3D phone if you don't have any 3D content to use on it? Movies are an obvious first choice, but, again, tough on the eyes. Some games actually were not horrible in 3D, but they were few and far between and, again, the eyestrain thing. The few 3D phones that came to market did so with "Hubs" of content, but the hubs weren't all that extensive and a little clumsy to navigate. You could upload your own 3D content to Youtube, but that never took off, either.
It's entirely possible we'll see another 3D mobile device at some point, but I wouldn't bet on it. Gimmicks generally aren't cheap, and nice devices tend to lack economy of scale needed for profits in such a tight space.
Motion controls. They're forever right around the corner as becoming "the next big thing". Whether it was Nintendo's PowerGlove from the 1980's or the Wii, the idea of throwing away the controller for using motion always seems so close. Heck, Nintendo's Wii, and later Microsoft's Kinect, could be argued as the moment of critical mass for this technology. The original Wii console has sold nearly 100 million units, while the Kinect add-on for Xbox 360 has been purchased by 24 million gamers.
Yet, they're still not exactly perfect just yet. From yelling repeat commands to missed movements, both Wii and Kinect do better than 50% for accuracy for most users but still far less than the reliability found in physical controllers, often leading to frustration and a novelty feeling.
Wii and Kinect could be argued as the moment of critical mass for motion control
In theory, the lack of learning the rapid button presses of a handheld controller could prove to be a benefit for those who have never 'gamed" before. The Wii and Kinect have clearly demonstrated that such a strategy can open doors to previous non-gamers by using simple gestures and motions like jumping and dodging. The question is, will it go beyond that?
Clearly Sony, Nintendo and Microsoft all see value in motion controls and are betting a lot on the technology. Between the current success of such systems and the rapidly improving know-how around it, motions controls will certainly play an important role in gaming for the future. Not only does it make gaming more accessible by, once again in theory, reducing the learning curve but it also gives game developers another avenue for creativity.
We've spent some time talking about the future of mobile gaming with regards to new and emerging technologies, but how is this all going to apply to the near-term future of mobile games? What is mobile gaming going to look like one year from now?
The truth is, it's not going to be much different than what we have today. The experiences we've talked about with motion controls and virtual reality headsets require new hardware and long lead times for developers. Oculus Rift developer kits haven't been out that long, and game developers are going to focus first on where development is going to be easiest - and that's desktop gaming. These new technologies will eventually filter down to mobile gaming, but it's going to take a while.
What's going to be interesting is watching how mobile game developers take advantage of the hardware currently available. The pace of hardware development has been accelerating over the past few years, to the point where we now have smartphones and tablets sporting quad- and octo-core processors. But here we are today with absurdly powerful hardware that games are just getting around to taking full advantage of. Of course, your battery life is going to suffer when they do.
AAA games might be where the money is, indie developers are where the innovation happens
It's going to be the big studios developing powerful AAA games with rich graphics that take advantage of all that hardware. But the big games play it safe, their going to be predictably entertaining, easy-to-play, and won't be pushing the envelope much outside of increasingly complex graphics and engines.
The independent developers, however, that's where the real innovation is going to happen. Their investment is smaller, but their potential for reward can be much greater with a breakout hit. Indie developers push the gameplay envelope, they're the ones that innovate with new gameplay concepts and control schemes and unique implementations of new technologies. We've said it before in this discussion - while AAA games might be where the money is, indie developers are where the innovation happens.
It's not likely that one year from today you'll be hooking up a virtual reality headset to your smartphone or waving your hand over its screen to control a game. But it's likely that two or three truly interesting and innovative games from a handful of small independent developers are going to take the mobile gaming world by storm yet again, pushing the envelope of what we consider entertainment.
It used to be the governments that funded the research of the future, or the educational institutions. Increasingly, now, it's entertainment. Superman made us believe a man could fly. Jurassic Park made dinosaurs once again walk the world. As entertainment grows beyond movies and TV, and millions of dollars flow into the big gaming franchises, that's how the future will be funded. That's why people will demand better graphics and more immersive digital experiences.
And that's exciting. The future is exciting.
We're standing on the precipice of the next revolution of technology, including virtual reality headsets like the much-anticipated Oculus Rift, gesture-based controls like Microsoft's Kinect and Leap Motion, and wearable computing in the form of Google Glass. Sure, some technologies have floundered. 3D has been beaten around and pretty much left at the curb. The future of the Wii U looks uncertain. But that's how the future is born.
We want what's next. Triumphantly, tragically, audaciously, absurdly next. We'll embrace the fantastic and merciless castigate the stupid. Just give it to us.
What's going to catch on, what's going to take off? That's the question. What's going to be the hot new display, control, and interface of the next 5 years?
It's your turn to tell us. What's going to be the future of gaming? | <urn:uuid:a1563166-198e-478c-bfb7-d5d65f1c6aad> | CC-MAIN-2022-33 | https://crackberry.com/talk-mobile/whats-future-mobile-gaming-talk-mobile | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.966287 | 2,126 | 1.875 | 2 |
A 19-year-old male asked:
I am curious to know if following the uberman cycle for a month will have any adverse long term effects on my health/cognitive functioning.?
1 doctor answer • 3 doctors weighed in
Clinical Psychology 46 years experience
Not known : There is little scientific knowledge about the effects of changing your natural sleep cycle to follow the uberman cycle. My hunch is that there are likely to be problems, perhap subtle ones, with trying to change millions of years of evolution that produced the five stages of sleep that are intimately interwoven with light-dark cycles and circadian rhythms, hormones, neurotransmitters ...
5.5k viewsReviewed >2 years ago
Last updated May 4, 2016
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Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency. | <urn:uuid:3e8782a5-e645-47d0-81f0-20db6641138d> | CC-MAIN-2022-33 | https://www.healthtap.com/questions/437584-i-am-curious-to-know-if-following-the-uberman-cycle-for-a-month-will-have-any-adverse-long-term-effe/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.922691 | 265 | 1.671875 | 2 |
FDA Continues Investigation and Recalls for Generic Sartan DrugsBy
The US Food and Drug Administration (FDA) is updating the agency’s ongoing investigation surrounding the recent voluntary recalls of multiple generic “sartan”-containing products, angiotensin II receptor blockers (ARBs), used to treat high blood pressure and heart failure.
Most recently, Hetero Labs, headquartered in Hyderabad, India, has announced a recall of 87 lots of losartan potassium tablets (25 mg, 50 mg and 100 mg). The recalled losartan potassium tablets, made by Hetero Labs and distributed by Camber Pharmaceuticals, based in Piscataway, New Jersey, contain the impurity, N-nitroso-N-methyl-4-aminobutyric acid (NMBA). Hetero identified NMBA in lots of losartan potassium during recent testing. The impurity is a known animal and potential human carcinogen. This is the first ARB recall resulting from the presence of NMBA, which is the third type of nitrosamine impurity detected in ARB medicines.
“We are deeply concerned about the presence of a third nitrosamine impurity in certain ARB medications, but it’s important to underscore that, based on the FDA’s initial evaluation, the increased risk of cancer to patients with NMBA exposure appears to be the same for NDMA [N-nitrosodimethylamine] exposure but less than the risk from NDEA [N‑nitrosodiethylamine] exposure,” said FDA Commissioner Scott Gottlieb, in a March 1, 2019 statement. “That said, any presence of such impurities in drug products is not acceptable. Over the past few months, the FDA has conducted a major investigation and has worked with drug companies to address the presence of impurities in these products.”
Recent testing of these recalled lots of losartan potassium tablets showed NMBA levels higher than the FDA’s interim acceptable intake limits. The FDA’s evaluation suggests that the nitrosamines found in ARBs may be generated when specific chemicals and reaction conditions are present in the manufacturing process of the drug’s active pharmaceutical ingredient, and may also result from the reuse of materials, such as solvents.
Gottlieb said that FDA scientists have developed novel and sophisticated testing methods specifically designed to detect and measure N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) impurities in ARB medicines. “Because of the potential for discovering other nitrosamine impurities, we are conducting an extensive organic chemistry analysis to develop novel testing methods to detect additional nitrosamine impurities, including NMBA,” he said.
“We’re continuing to share these testing methods with international regulators, industry and the public to help manufacturers and other regulators evaluate these products for any potential nitrosamine impurity. We are making important strides at understanding how these impurities form, and we are continuing to examine if nitrosamine impurities may also arise during the manufacture of other ARB drug products,” said Gottlieb in the FDA statement.
NMBA has not been found in previously recalled ARB products; however, the FDA is continuing its investigation. Previously, two other nitrosamine impurities, NDMA and NDEA, were found in drug products containing the active pharmaceutical ingredients valsartan, losartan and irbesartan, and those products containing nitrosamines above the interim acceptable limits were recalled.
Recent FDA analyses of NDMA and NDEA in recalled valsartan found that overall, the risk to individual patients is very low although this doesn’t diminish the significance of this issue or the FDA’s concerns. The agency continues to evaluate the risks nitrosamines pose to patients. The FDA and drug manufacturers continue to test all ARBs for nitrosamine impurities. “If NDEA, NDMA, NMBA, or other nitrosamine impurities are found in products at levels above the interim acceptable intake limits, the FDA will work with companies to swiftly remove affected products from the market,” said Gottlieb in his statement.
The FDA said it will continue to update the list of products included in the recall as more information becomes available from ongoing testing.
Source: US Food and Drug Administration | <urn:uuid:9587b72a-56e9-4157-a53a-c854b5a305d2> | CC-MAIN-2022-33 | https://www.dcatvci.org/top-industry-news/fda-continues-investigation-and-recalls-for-generic-sartan-drugs/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.933599 | 928 | 1.867188 | 2 |
Mobile phones have come a long way from being just something we use for making calls and sending texts. We use them to connect on social media, browse the Internet, learn languages, and play games among others. If you have an iPhone in your pocket, you are probably aware of the many apps you can get and the cool things you can do. But the iPhone might have kept a few secrets from you. If you’d like to learn a few tricks or know more about the revolutionary smartphone, here are eight interesting facts you probably didn’t know about the iPhone. If your iPhone has been damaged and needs immediate iphone repair, it may still be restored with the help of a damaged apple iphone repair service.
1. Boosting charging with a trick
Charging is the bane of owning a phone. Not only do we love to complain about the battery life on our phones, but we also hate waiting for charging to finish. Luckily, there’s a secret trick to boost your iPhones charging speed. Before plugging the phone it’s charger, simply change it to ‘airplane’ mode from the Settings. This will speed up the charging process slightly and help you enjoy your phone’s great abilities quicker.
2. Switch vibrate to lights
The vibrating feature is great for those occasions when you don’t want to have the sound on, but still need to stay on top of incoming calls or messages. But occasionally, even the vibrating feature can make a little bit too much noise. To avoid it from causing a problem, use the lighting feature instead. This allows you to emit an LED flash whenever you get a call or a text. You can do so by going to Settings -> General -> Accessibility. And if you don’t mind the vibrating feature, you can customise it to a specific pattern!
3. Keep an eye on the ads
Apple is known for paying a lot of attention to detail and iPhone advertising isn’t any different. The company is famous for the 1984 ad for its computer, but next time you see an iPhone ad, look at the time. It will most likely show all the featured phones displaying a specific time of day: 09:41. This is not a coincidence, since that happens to be the time of day Steve Jobs first unveiled the iPhone in 2007.
4. Shake your head
Did you know you could control the phone by simply moving your head? It’s possible to enable the head gesture control and access Siri by simply moving your head. The function is available from the Accessibility section and it’s a great little tool for people with limited hand functions, for example. It’s also rather cool to be able to control your phone by just tilting your head to the left!
5. Go multilingual
If you speak more than one language, then you might know the frustration of typing with your iPhone. Setting it up on one language (like English) and then texting a friend in another can be a struggle. But if you’ve updated your operating system to iOS 10, you can forget about the trouble. The keyboard will now allow multilingual text prediction, which can help you communicate faster and without breaking into a rage!
However, if you’re looking for good provider that offers a vast array of multi-language translation services to meet all of your needs then this Transcription services here can provide you both same-language and multilingual transcripts in over 150 different languages, covering many dialects and accents, and services like Espresso Translations also help people to translate in other languages like Arabic.
6. The phone might have been called ‘mobi’
The iPhone wasn’t always known as the iPhone, as the company considered a few different options when it was developing it. The project to develop the new phone was codenamed Project Purple, with the team throwing around a few ideas before settling with the iPhone. What do you think? Would ‘mobi’, ‘telepod’ or ‘tripod’ have sounded quite as cool as the iPhone? In fact, the team even considered the name iPad, which of course is the name of their other revolutionary gadget.
7. DIY tools at your service
The iPhone can be a handy help if you are doing a bit of DIY around the house. The phone can be used as a level to ensure your surfaces are straight and flat. Go to the compass app and swipe left to reveal this hidden feature.
8. Going grey
If you’d like to save your iPhone’s battery and dim colours of your day for a moment, you can use the device in grey scale mode. You can turn the colours off from the Accessibility section and immediately dim the screen and use less battery. The function can be useful during nighttime or when you are just trying to ensure the battery lasts just a tad longer. It also looks rather cool and unique! | <urn:uuid:2b3767c7-e4cd-4e92-86b4-82fe0cf1ea14> | CC-MAIN-2022-33 | https://venture1105.com/2017/01/8-incredible-facts-you-didnt-know-about-iphone/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.939443 | 1,028 | 2.015625 | 2 |
An ad for Gamer Advantage, a company that sold blue-light glasses, seen in March 2022 during a livestream video by BobDuckNWeave on Twitch.
The ad featured Bryan Reedy from Gamer Advantage, who spoke to camera and stated, “The reason this lens is so important and so special is because that [sic] it has been clinically proven to attack blue light at a very specific nanometre that our clinical trials have shown supressed melatonin”; and “We are the first clinically proven lens to stop the suppression of melatonin so you can get a better night’s rest; and sleep is the number one medicine, and has been since the beginning of time.”
The ad also included a clip of several people trying on glasses. A man stated, “You can take all the massages, the recovery, all of this stuff, but sleep is the basic foundation.”
IssueThe complainant, who understood that blue-light glasses were not scientifically proven to improve sleep quality, challenged whether the claims in the ad were misleading and could be substantiated.
Gamer Advantage LLC said that their lenses filtered the correct wavelength in order to achieve an increase in melatonin production. They said that melatonin production was an essential step in the sleep cycle and that it was well-documented that there was a link between suppressed melatonin and exposure to artificial light sources.
They submitted a Masters’ thesis, two scientific posters, a news article, and an ophthalmologist’s comments, which they said supported the claim that Gamer Advantage blue-light glasses were scientifically proven to improve sleep quality.
They also said that the claim “sleep is the number one medicine” was similar to saying “laughter is the number one medicine”.
The ASA acknowledged that light from artificial sources, particularly mobile phones, computer screens and tablet devices, emitted blue-violet light. However, we understood that there was little scientific evidence to prove that blue-light filtering lenses improved sleep quality.
As such, we considered that a substantive body of relevant evidence was needed to prove the claims, consisting of clinical trials conducted on humans that had been published and were peer-reviewed. However, when we assessed the evidence provided by Gamer Advantage, we considered that it did not meet the standard of evidence we required for the type of claims being made.
The first document was an unpublished Master’s thesis which was not peer-reviewed. The second was an unpublished scientific poster which was also not peer-reviewed, and stated that a causal relationship between melatonin level changes in response to wearing Gamer Advantage blue-light glasses could not be established. The other scientific poster was also unpublished and had a sample size of ten. The news article, which reported on a study presented at a scientific conference, featured in a scientific journal. We noted that the article did not definitively conclude that Gamer Advantage glasses improved sleep quality, and in any case we had not seen the actual study. We also considered that, in all of the evidence submitted, any sample sizes used or referred to were too small for results to be extrapolated to the wider population. Whilst we acknowledged the ophthalmologist’s comments, we considered that they did not constitute documentary evidence and as such could not take them under consideration.
Therefore, we considered that the evidence submitted was inadequate to support the claim that Gamer Advantage blue-light glasses were able to prevent a reduction in melatonin production, and thus, improve sleep quality. Because the evidence was not sufficient to establish a direct link between Gamer Advantage blue-light glasses and improved sleep quality, we concluded that the claims were misleading and had not been substantiated.
The ad breached CAP (Edition 12) rules
Marketing communications must not materially mislead or be likely to do so.
Before distributing or submitting a marketing communication for publication, marketers must hold documentary evidence to prove claims that consumers are likely to regard as objective and that are capable of objective substantiation. The ASA may regard claims as misleading in the absence of adequate substantiation.
Marketing communications must not mislead consumers by exaggerating the capability or performance of a product.
Objective claims must be backed by evidence, if relevant consisting of trials conducted on people. Substantiation will be assessed on the basis of the available scientific knowledge.
Medicinal or medical claims and indications may be made for a medicinal product that is licensed by the MHRA, VMD or under the auspices of the EMA, or for a CE-marked medical device. A medicinal claim is a claim that a product or its constituent(s) can be used with a view to making a medical diagnosis or can treat or prevent disease, including an injury, ailment or adverse condition, whether of body or mind, in human beings.
Secondary medicinal claims made for cosmetic products as defined in the appropriate European legislation must be backed by evidence. These are limited to any preventative action of the product and may not include claims to treat disease. (Medicines, medical devices, health-related products and beauty products).
The ad must not appear again in its current form. We told Gamer Advantage LLC not to make claims that their blue-light glasses could improve sleep quality in the absence of adequate substantiation. | <urn:uuid:facb6957-97d6-43a4-baba-026443905b50> | CC-MAIN-2022-33 | https://www.asa.org.uk/rulings/gamer-advantage-llc-a22-1147415-gamer-advantage-llc.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.968498 | 1,141 | 1.53125 | 2 |
Well, that didn’t take long. On Friday, Russia’s defense minister raised a hungry world’s hopes by signing an agreement with the president of Turkey and the secretary general of the United Nations, according to which Moscow committed to facilitate resumption of large-scale grain shipments from Ukraine’s Black Sea ports. Russia had previously blockaded these, causing stress on global grain markets. Less than 24 hours later, on Saturday, Russian ships launched four long-range missiles at the largest of those ports, Odessa, two of which Ukrainian air defenses intercepted — and two of which caused some structural damage, though no destruction of grain or human casualties. The United States’ ambassador in Kyiv called the attack “outrageous,” which is an understatement.
Saturday’s events were not surprising to those familiar with President Vladimir Putin’s record, in this war and others. He is notorious for violating humanitarian agreements establishing safe “corridors” through which Russian forces and their allies herded Syrian civilians escaping war zones in that country. Often, the fleeing people came under fire or faced violent harassment and arrests. Compliance with the new accord would force Russia to abandon its strategy of denying Ukraine agricultural export earnings, including stealing, and reselling, Ukraine’s stockpiled grain — even, in some areas, burning crops. Depending on where the missiles actually struck, Russia might not have violated the letter of the agreement, under which it reserved the right to strike sections of Ukrainian ports not directly used for grain exports. Still, it clearly violated the spirit.
All of the above helps explain why Ukraine was wise not to deal directly with Moscow, but to sign up for a process that, technically, consists of parallel commitments Ukraine and Russia each made to Turkey and the United Nations. Ukraine prudently offered only escorts through its maritime minefields, not actual demining, lest it weaken defenses against Russia’s navy.
At the same time, Ukrainian officials were wise to announce after Saturday’s attack that they will continue pursuing the agreement, which would have taken some time to implement in any case. Not only is it still in Ukraine’s economic interest, but one goal of Russia’s attack was likely to provoke a Ukrainian pullout, after which Moscow would blame Kyiv for the consequences. And the downside of a failed deal can be measured by the potential upside of a successful one: Ukraine produced a tenth of the world’s wheat exports during 2021 — with populous countries such as Egypt, Bangladesh, Turkey, Indonesia and Pakistan, as well as small and economically struggling Lebanon, among the biggest customers. The United Nations World Food Program, which distributes aid to the world’s poor, got 40 percent of its wheat from Ukraine before the war. With even wealthy nations hammered by rising food prices, millions of people around the world could benefit from a flow of 20 million metric tons of Ukrainian grain and other foodstuffs to the world market over the next 120 days.
If Mr. Putin destroys the deal before it gets started — despite the advantages it offers his agricultural exports — he must take the blame. Meanwhile, Turkey and the United Nations must fulfill their roles as guarantors by holding him accountable, and the United States must send weapons Ukraine needs to protect its ports. | <urn:uuid:db128dc0-29f4-4adb-8e3f-dea63bdb13f8> | CC-MAIN-2022-33 | https://www.washingtonpost.com/opinions/2022/07/24/ukraine-russia-grain-shipment-deal-optimism/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.963332 | 679 | 2.109375 | 2 |
The action in Poker begins when the dealer deals a hand. The dedicated dealer button moves one spot clockwise after each deal. This identifies the starting position. Players always start on the left of the button. Before the game begins, the player to their left must post a small blind and a big blind. These are forced bets, which give the other players something to chase after. Then, the dealer indicates a new starting position for the next hand.
The best hand in poker is known as the “nuts.” It is made up of all four cards of the same rank. Other hand combinations include a straight, three of a kind, and a different pair. A high-card hand, on the other hand, is a five-card combination. Ultimately, the winning hand is a combination of all five cards in the same suit. Depending on the suit, a straight will also be a winning combination, but a high-card hand will be the best of all.
Every round of the game has a dealer. This person is responsible for shuffling the deck and dealing the cards to the players. This role is sometimes assigned to a non-player. Each player takes turns being the dealer. Each player receives a dealer chip, which designates them for a round. When a player changes the dealer, the chip is passed to the new dealer. Certain betting rules depend on where the dealer is. The dealer must offer a cut to his opponent, who may cut the dealer.
Before the next betting round, players must contribute an ante to the pot. The ante is the amount of money in the pot minus the call cost. For example, a $10 bet increases the pot to $110, and the call cost to call a player is ten dollars. With a 10-to-1 pot odds, it is better to call if you have better odds. If the odds are worse, consider doubling down.
In poker, players make wagers according to the value of their hands. Each hand has its own value, which is inversely proportional to its mathematical frequency. To win a poker game, you must know how to recognize a fair or bad hand and make the right decisions. Poker tables will tell you what kinds of hands are good, fair, or bad. Then, you can make the right bet based on these hands. This strategy is called bluffing.
Another way to play poker is by calling for new cards. Some clubs use two-pack games that speed up the process. The best players usually use two-pack games. In these games, the new cards are introduced to the deck. The cards are sealed in cellophane before being dealt. Breaking the cellophane wrap is an essential step for playing poker. If you have a high hand, you should try to win the game with the lowest hand.
In poker, players typically use poker chips to make decisions. These chips come in various colors, and the dealer assigns a value to each chip. Players exchange these chips with cash before each betting round. The dealer then deals the players’ cards. The dealer shuffles the cards after each hand. The best hand wins the pot by making a bet that no other players call. For more than 10 players, you can also organize two separate games. | <urn:uuid:581912c3-9edb-4d7e-a508-f14394f5264d> | CC-MAIN-2022-33 | https://www.cartagenaconventionbureau.com/the-basics-of-poker-3/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570793.14/warc/CC-MAIN-20220808092125-20220808122125-00672.warc.gz | en | 0.961719 | 667 | 1.96875 | 2 |
If you’re living in the Sunshine State, you know that there’s a downside to sun-filled days on the beach, and that’s sun damage. The Skin Cancer Foundation says too much sun can also cause precancerous conditions, such as actinic keratosis, and skin cancer.
The good news is that it happens gradually, and you still have time to start a regimen to keep it from getting worse. With up to 90 percent of skin damage caused by the sun, it’s easy to know where to start.
How to Get Rid of Sun Damage
- Wear sunscreen with an SPF of 15 or higher all year long. Daily use will keep you looking younger and lower your chances of getting skin cancer.
- Hydrate. When you’re around sun, chlorine and salt, your skin dries out. First, drink lots of water. Creams with alpha hydroxy or hyaluronic acid brighten the face, and moisturizers work well on the hands, arms, and feet.
- Exfoliate. The outer layers of skin build up and give a blotched, uneven texture. Scrubs, loofas, acids like alpha hydroxy, and do-it-yourself dermabrasion kits help you to look younger and more radiant.
- Avoid the sun. Ultraviolet (UV) light can cause precancerous spots like actinic keratoses, or it can lead to skin cancer. Always wear a hat, limit exposure, and avoid the mid-day sun.
- Bleach. Skin lighteners help to lighten brown spots, but they don’t lighten your skin tone. Products that contain kojic acid and Retin-A, steroid cream, or hydroquinone are effective and easy to use.
- Use an at-home light-emitting diode (LED) to reduce fine lines and wrinkles, improve acne, and encourage collagen production.
- See a dermatologist. If DIY tricks and a good skin regimen don’t do the trick, you still have options in the doctor’s office. Laser treatments work for everything from wrinkles to blotchiness. A combination of aminolevulinic acid and intense pulsed light can do wonders for scaly skin.
Where to Learn More About How to Reverse Sun Damage
If you’re looking to reverse skin-related sun damage, you have plenty of options. At Divine Laser & Spa, we offer sun damage treatments that may help you regain your youthful skin. Contact us today for more information. | <urn:uuid:c579c2c8-484d-429f-ae11-bc0e62bf9bfb> | CC-MAIN-2022-33 | https://www.divinelaser.com/reverse-sun-damage-in-7-easy-steps/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.888033 | 536 | 2.34375 | 2 |
What does Amrut mean?
The meaning of Amrut is : Nectar, Nectar that promises Immortality, Food of Lord's according to Hindu Myth
each letters holds a specific meanings that describe the nature of the name. Below in table, each letter of name Amrut described.
|Name||Meaning of the Alphabet|
|A||You are your own person, natural leader, ambitious and freethinking.|
|M||You are a workaholic! A high-energy workhorse, you don't need much sleep and are very healthy. You also really like to be a homebody, however, and need a steady financial base in order to feel secure.|
|R||You feel things strongly and your rich, intense inner life emanates outward. You also have an excellent work ethic and can do your job with high amounts of energy.|
|U||You have a give-and-take kind of life. You might gain a lot, only to lose it, but will always break even.|
|T||You like life in the fast lane. Remind yourself to slow down, because you are often taking on new and exciting projects. You're also assertive, even aggressive, in your personal relationships.|
Nectar, Nectar that promises Immortality, Food of Lord's according to Hindu Myth
State of deathlessness, Immortality, Divine nectar of the God, Beautiful, a veritable drink which gives immortality
Nectar, Beautiful, a veritable drink which gives immortality
State of deathlessness, Immortality, Divine nectar of the god
The Moon, The Moon
Sea or ocean of Nectar that promises Immortality, Sea or ocean of Nectar that promises Immortality
Name of Lord Shiva, One of many names of Lord Shiva with reference to the moon on his head
Moon Like, Moon Like
A person who is the sweetest, A person who is the sweetest
Nice good one
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Trusted by 10+ million young parents Mylo is India’s #1 Pregnancy & Parenting App. Mylo app will guide you through your whole parenting journey. Download now | <urn:uuid:1eb57060-52ed-494b-a0a7-bf438a2414dd> | CC-MAIN-2022-33 | https://mylofamily.com/parenting/babynames/meaning-of-Amrut-1341 | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.93001 | 477 | 2 | 2 |
WORLD AIDS DAY: Events Held Around The State
Events are being held today throughout the state as part of World AIDS Day. Listed below is a schedule of events.
- San Francisco: An event will be held at the National AIDS Memorial Grove in Golden Gate Park from 11 a.m. to 1 p.m. to honor activist Irene Smith with the First Annual Grove Award for HIV/AIDS Community Service. The event also features author Armistead Maupin and actress Judith Light. A candlelight vigil will be held from 6 p.m. to 8 p.m. at the Luggage Store Annex, 1000 Market St. Elsewhere, six "teenage AIDS ambassadors will promote AIDS awareness among young people at 10 a.m. at the Community Meeting Room, Main Library" (Pimentel, San Francisco Chronicle, 12/1).
- Los Angeles: To commemorate the day, the Los Angeles County Department of Health Services is announcing the impact of AIDS locally and providing information on the county's 70-80 World AIDS Day events being held to educate young people about HIV prevention and treatment. The agency is encouraging young people to get tested and return for their results.
- San Diego: A Tree of Life will be lighted in a ceremony at 6 p.m., and an accompanying presentation will feature San Diego Council members Christine Kehoe and Barbara Warden. Panels of the NAMES Project quilt will be displayed at a number of locations throughout the city. Mayor Susan Golding (R) has declared Dec. 1-6 "Ordinary Miracles Week." Ordinary Miracles, a nonprofit organizations, hopes to raise $50,000 to benefit AIDS groups by encouraging restaurants, hairstylists and other businesses to donate a portion of their profits for one day.
- Claremont: A panel discussion on the current status of AIDS treatment, sponsored by the Foothill AIDS Project and Claremont College, begins at 4 p.m. A candlelight walk begins at 5:30 p.m., followed by a memorial service and a fundraiser.
- Oakland: Kaiser Permenente announced today that it will launch a community outreach program for East Bay residents with HIV/AIDS (release, 12/1).
- Sacramento: Mayor Joe Serna Jr. (D) and AIDS activists will speak about AIDS on the steps of the Capitol, followed by a candlelight march to the Cathedral of the Blessed Sacrament at 11th and K streets (Hubert, Sacramento Bee, 12/1). | <urn:uuid:b1424569-ba84-422e-a00e-14efe7f32c4c> | CC-MAIN-2022-33 | https://californiahealthline.org/morning-breakout/world-aids-day-events-held-around-the-state/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.931149 | 512 | 1.5 | 2 |
The Postal Service reminds employees to protect sensitive or sensitive-enhanced information when sending emails from work computers and devices to external or non-postal recipients.
Employees who are authorized to share these types of information with external recipients should use the Enterprise Encryption Service to ensure safe transmission.
Sensitive and sensitive-enhanced information includes:
- Personally identifiable information
- Confidential business or proprietary information
- Financial information, such accounts, payroll and travel reimbursement information
- Credit and debit card data
- Health information of an employee, customer or supplier
All employees should use Postal Service computers and devices responsibly.
The CyberSafe at USPS site has additional information security tips and detailed guidance about encryption. | <urn:uuid:0d70b93d-71cd-4623-a69d-b3f4684a4f88> | CC-MAIN-2022-33 | https://link.usps.com/2016/05/24/out-of-network/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.851199 | 143 | 1.921875 | 2 |
Research and Development
Fraunhofer FOKUS conducts in bilateral,national and international projects applied research in the field of Information-and Communications Technology.
A key area of the work of FOKUS consists in the conception and implementation of research and development projects of any size. The cooperation is carried out project oriented or on the basis of long term cooperation contracts. The focus is a requirement- and, if possible or necessary, standard-oriented solution development within the research topics of FOKUS.
Furthermore FOKUS is closely engaged in the research programs of the European Commission and the national funding bodies. On the basis of the broad technology and application knowledge as well as the activities in numerous standardization committees, FOKUS is a highly sought-after partner in consortiums.
- Development of communication and information technologies, components, services and solutions in the areas of mobility, public safety, administration, media, energy, healthcare and industrial automation
- Integration and interconnection of systems in these areas
- Quality assurance and certification of these systems
- Implementation, demonstration, piloting and evaluation of systems and solutions
- Adaptation of proprietary interfaces and systems for industrial, national and international standards
- Methods and tool development for these systems and solutions and accompanying processes
Consulting and Training
The autonomy from interests driven by manufacturers and politics combined with a broad technology and application knowledge characterizes FOKUS as a consulting partner in all process steps.
- Conception of research and development projects, research programs and their implementation or monitoring
- Feasibility studies in the setting up of new and conversion of existing communication infrastructures, services and applications
- Technology, process and tool reviews for the application in practice and trend development
- Moderating consultancy in decisive phases
- Project management and quality assurance in large-scale projects
- Technology-, product- and application-oriented training | <urn:uuid:1f716f57-c233-4d92-ba31-613c9d0fac7e> | CC-MAIN-2022-33 | https://www.fokus.fraunhofer.de/en/fokus/services | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882570793.14/warc/CC-MAIN-20220808092125-20220808122125-00672.warc.gz | en | 0.905929 | 405 | 1.5 | 2 |
Uninstall RPM Step
You may use this step to uninstall RPM packages.
To create an uninstall RPM step:
- Enter the
Namefor your uninstall RPM step.
- Use the
RPM Packagesfield to list the RPM packages you want this step to uninstall.Important: Packages must each be listed on a new line separated from the next.
- (Optional) You may choose to specify the following:
Erase Options(also as a new-line separated list) to be used during the uninstall. | <urn:uuid:dbe33cc3-6c48-4970-91cd-9f32583944d3> | CC-MAIN-2022-33 | https://admhelp.microfocus.com/da/en/6.3.3-6.3.5/online_help/Content/PluginHelp/sra_plug_proc_rpmuninst.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.748585 | 108 | 1.539063 | 2 |
Payroll Calendar Nyc Doe 2020 – In terms of payroll, you should keep organized. It is essential to avoid all problems or issues associated with your company’s payroll. You should create a excellent payroll template for your company. One that can be used to provide your staff the correct benefits in a timely manner.
Models of payroll templates
You must know what template to make, before making an Excel payroll template. You can find different types of templates you could make for your enterprise. No matter what type you choose, it should enable you to organize your payroll system. The kinds of payroll we listed below are just handful of illustration, there are moe kind of payroll than we shown below.
- Daily payroll design
- Bi-weekly payroll layout
- Weekly payroll design
- Monthly payroll design
Tips for producing payroll styles
Using a payroll worksheet template is really a practical approach to standardize payroll processes. Help make your personal templates completely from scratch or down load a single here to save lots of oneself some time.
You may perhaps want to make a template for the payroll method. In cases like this, look at the info to add.
Consider your payroll plans, particularly if you’re in the beginning stages. You should establish each one of these guidelines and navigate your staff about them. Do this in order that everyone in the business is properly-well informed in terms of the payroll. Here are some ideas for you:
Ensure every piece of information on your own template is completely correct. If you obtain a template, proceed through it to view if you wish to alter something. Make modifications in order that the template will fit your very own business needs. Verify the file prior to utilizing it to successfully did not miss anything.
Your pay-roll templates should be user friendly. Regardless of whether you and your workers apply it, there should not be any problems. Keep it uncomplicated but full so it is not perplexing to anybody.
The template you make should raise the efficiency of your pay-roll method. It shouldn’t become a ineffective document which just adds to your papers trail. Make or select templates that can help your organization’s work-flow.
Ultimately, be sure you can change the template. Whether or not you are making it or down load it, you need to have the option to modify it. You may have to change your template too if you can find any changes in your payroll guidelines.
Only you are able to see whether you require a easy or intricate template. No matter what kind of template you make use of, this will be very beneficial for the enterprise. | <urn:uuid:32ee8a48-98d9-4f19-931c-4567381ba21c> | CC-MAIN-2022-33 | https://payrollcalendars.com/payroll-calendar-nyc-doe-2020/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.89551 | 538 | 1.757813 | 2 |
Chatbots Development allows you to automate the process of conducting online trading. Scripts help users find the right product positions and answer their questions. Chatbots will become indispensable assistants for owners of online stores with high traffic.
Before developing a chatbot, you need to decide on the script functions, dialog interface, and platform selection. The cost of development depends on the complexity of the script, its features and functions. There are several types of chatbots among the popular options.
One of the most popular developments is considered to be a script-based chatbot. It is quite simple and programmed to conduct a dialogue with potential buyers, answer their questions.
Despite the lack of flexibility, script-based chatbots are able to close most important tasks.
Smart chat bots are a more advanced type of online assistant. It is based on artificial intelligence technology, thanks to which communication with users occurs in a natural way.
Intelligent agents are used on the most popular projects of the world level. They include two technologies at once: machine learning and artificial intelligence.
For owners of online stores, a script-based chatbot is quite suitable. It perfectly handles the functions assigned to it as a support representative, helps to maintain the order status, and send notifications.
The development of the dialog interface is necessary to create an environment in which the user and the chatbot interact. The dialog interface is important for the natural process of communication.
The dialog Initiator must be the user. They ask questions to the support representative and immediately get a prompt response.
The Script is designed in such a way that in case of difficulties, it can connect a live consultant to the dialog.
Developers use popular platforms that allow you to adapt a chatbot to an online store.
The Chatfuel Platform makes it easy to configure the basic rules for conducting a dialog. Received user questions are processed, which allows the system to recognize them and build correct responses.
Chartfuel is ideal for online store owners who plan to build a dialogue with users using Facebook Messenger or Telegram. The platform has several pricing plans, including paid and free options. | <urn:uuid:80e4e1d4-3cce-4a92-a949-b5a239d4941d> | CC-MAIN-2022-33 | https://myhosti.pro/en/blog/internet_technologies/razrabotka-chatbotov-sovremenniy-instrument-razvitiya-biznesa | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571056.58/warc/CC-MAIN-20220809155137-20220809185137-00672.warc.gz | en | 0.934706 | 429 | 1.992188 | 2 |
You’ve ensured two things in life– death and tax obligations. While taking care of your physical and psychological health and wellness can lead to a longer, healthier life, economic planning and strategising can minimise your tax liabilities. Everyone wishes to pay much less come tax obligation time. For those checking out financial obligation combination and credit history repair services, learning exactly how to decrease your taxable income can maintain even more cash in your pocket and assist you to settle your financial debts faster. Our listing of 15 very easy means to decrease your taxable income in Australia can help.
How to Lower Gross Income
What are the simplest ways to pay less tax obligation this year in Australia? We have rounded up 15 of the most convenient means to pay much less tax obligation that can assist you in reaching your cost savings as well as financial debt decrease objectives much faster.
1. Usage Wage Sacrificing
For those trying to discover exactly how to conserve tax obligation in Australia, income giving up is one way to do it. This is likewise called “salary product packaging,” and it functions in a couple of different methods. With wage compromising, a taxpayer would certainly put a few of their pre-tax income toward an advantage before they are strained. Some of the most typical wage sacrifice benefits are automobile as well as superannuation.
So, a staff member would discard part of their pre-tax paycheck before they get it. For example, they could use income compromising on paying for a brand-new vehicle, computer system, insurance policy, rent out settlements, home loan payments, and various other advantages. These benefits are also referred to as “fringe benefits,” They can save Australians countless bucks in tax obligations annually, with a couple of exemptions.
There is a limitation on what can be income sacrificed, also called a wage package. Additionally, Edge Perks Tax, or FBT, can impact the sorts of advantages your company offers. For instance, employers will use to salary plan an auto as a novated lease. This is an arrangement between your employer, you, and a financer and is one means to obtain access to a brand-new car while minimising your taxable income. If you wish to boost your reimbursement this year, you could also consider salary packaging your superannuation.
2. Maintain Accurate Tax Obligation as well as Financial Records
The ATO is far more likely to ask many questions about your tax deductions than they were a few years earlier. If they ask about your reductions, you’ll require to show them invoices for tax deduction cases. However, not having an audio filing system can create many headaches for your tax obligation time. Many Australians miss out on deductions they can legitimately assert as a result of a lack of noise record keeping. If you make this mistake, the ATO will certainly keep your hard-earned cash that ought to have stayed in your pocket.
Lots of people question if they need to monitor every single reduction. Yet, the most effective thing to do when it involves declaring deductions and pleasing the ATO is to keep track of the reduction receipts. This will certainly make it much easier for you to remember what you can claim. Record-keeping does not need to be made complex.
Devote 10 mins of your time each week to download and install declarations as well as upgrade your logbooks. Make sure you keep all your invoices in a conveniently accessed, organised, as well as user-friendly file folder or filing closet. Keeping precise tax records will certainly conserve you a lot of time looking for every little thing at the end of the fiscal year, and also, best of all, you’ll be able to declare your deductions and ultimately pay much less in taxes.
3. Case ALL Reductions
If you spend any money on anything about gaining revenue, you’ll intend to assert it. Make certain you declare all deductions feasible to pay much less tax obligation in Australia. Even things that may appear small and insignificant can amount to significant financial savings at the end of the fiscal year. For example, if you bought something that is made use of for work, yet you likewise occasionally utilise it throughout your pause the clock, you can still assert the cash you spent on it as a work-related tax reduction.
If you’re not sure whether or not you can claim a certain item as an occupational tax obligation deduction, keep the invoice of purchase as well as ask your tax agent when you file. It’s constantly far better to hang on to receipts and not assert the product than to throw the pass and lose out on tax obligation cost savings.
4. Feeling Philanthropic? How to Pay Less Tax with Donations
Every donation you make to a registered charity above two dollars is thought about tax-deductible. After donating, the organisation must send you a receipt. Make sure to file that away for tax obligation season. When tax time rolls around, add up your philanthropic invoices as well as go into that right into the “charity donations” section in your tax return. However, remember that contributions do not come back using a tax reimbursement. Instead, the quantity of the monetary gift is reduced from your total gross income, meaning you’ll come back a percentage of the donation.
5. Minimise your Taxes with a Home Mortgage Offset Account
If you have a home loan, a home mortgage balanced out account lets you offset your non-deductible passion on the mortgage with interest on the standard, taxable profits of cash in a down payment. With this setup, taxpayers can produce an interest-bearing account with their loan provider. Yet, instead of paying passion on the entire amount of the home mortgage, taxpayers are charged interest on the financing, minus the cash in the savings account.
6. Contribute to Your Super (or Your Spouse’s) to Conserve Tax Obligation in Australia
Concessional super payments are strained for 15 per cent once they go into a very fund. This is different from if they were tested at a marginal price, often as high as 49 per cent. What are the various kinds of concessional contributions you can make? You can make the adhering to concessional payments to decrease your taxes:
- Salary giving up
- Personal insurance deductible payments
There is no earnings tax obligation limit on salary sacrifices. Freelance or unsupported taxpayers can make contributions to their supers and assert a full tax obligation deduction.
7. Get Private Medical Insurance
You ought to do this if it makes sense. Suppose you don’t lug an exclusive health center insurance policy, but you’re single as well as make more than 90,000 bucks a year, or you’re a household and make greater than 180,000 dollars per year. In that case, you will certainly pay a minimum of one per cent Medicare Levy Additional charge. The Medicare Levy Additional charge is additionally gathered on top of an obligatory 2 per cent Medicare Levy that many taxpayers need to pay anyhow.
Fundamental, private healthcare strategies can set you back less than the one per cent of Levy Additional charge on your gross earnings, which would certainly be less than the Medicare Levy you’d pay without insurance coverage. For some individuals, complete medical care could be worth it to reduce your taxes. Depending on your needs and case history, it could also deserve it for the usually shorter wait times you’ll get with private health care.
8. Minimise Resources Gains and also Minimise Tax Obligations
Any significant assets offered in a provided fiscal year, such as shares, or residential or commercial property, undergo a resource gains tax. If the financial investment has been held for at least one year, you’ll be charged a half resource gains tax obligation in addition to your limited tax rate. Funding gains tax obligations have to be paid in the year they are understood. Nonetheless, losses can be carried forward but not back. Tax obligations payable within the financial year can also be reduced if you pre-pay insurance deductible interest.
On financial investments, you can pre-pay expenses as much as twelve months in advance. So, interest on financial investment lendings and also monitoring costs can be claimed this financial year. If you have a considerable tax obligation responsibility from selling an asset, pre-paying can help you conserve cash on taxes.
When it involves taxes and residential or commercial property, one more tax exception from Capital Gains Tax Obligation is if your residential property is your main address or PPOR. You can assert the major home exemption from Capital Gains Tax obligation for your home. To get it, you’ll need to have resided in your home, or the property needs to have a house on it that you live in. Discover more concerning how to decrease Resources Gains Tax obligation for building made use of for service and financial investment purposes.
9. Pre-pay Costs
If you pay for some income-related expenses ahead of time, it can lower your gross income by relocating your reductions to the following financial year. This will certainly give you a higher tax refund. All pre-paid expenditures need to be less than a thousand bucks or satisfy the 12-month regulation for pre-paid expenses. The 12-month rule allows you to assert a reduction as a pre-paid cost as long as the service doesn’t exceed twelve months and stops in the next financial year.
10. Hold-up Earnings
Discover just how to decrease tax with this cool little technique. You can postpone obtaining earnings until June 30, which will certainly aid you to prevent paying tax obligations in the current financial year.
11. Do Not Consist Of Non-Taxable Earnings
The ATO considers some income that is exempt or non-taxable, and you don’t want to include it on your tax return. However, certain excluded income could be thought about when tax losses of earlier earnings years are calculated. You can deduct some earnings and also the changed gross income of any dependents you have. Excluded or non-taxable income includes the following:
- Some Australian Federal government pension plans, consisting of special needs support pension plans from Centrelink to those who are more youthful than pension age
- Some Australian Government repayments and allowances, e.g., the child care aid and also carer allocation
- Abroad pay and allocations for Federal Authorities workers as well as Australian Support Pressure
- Australian Government education and learning repayments, consisting of allocations for students younger than sixteen
- Particular scholarships, awards, and also grants
- Lump-sum settlements from the surrender of an insurance plan, home mortgage defence, or as repayment for a terminal ailment or work-related injury
12. Use Offsets
Tax offsets, also referred to as tax rebates, can reduce your taxable income by fulfilling particular qualification demands. While, in theory, these offsets might reduce your tax obligation expense to no, they won’t get you a tax refund. Revenue examinations are several of the most typical tax offsets.
13. Meet ATO Due Dates
If you sign up with a tax agent, the income tax return can be lodged as late as May of the next financial year if you aren’t in dispute with the Tax Office. But also for everyone else, all returns should be lodged by October 31. Fulfilling all ATO target dates can help you prevent problems and also fines. Self-lodgers with simple financial resources and scenarios usually submit their tax obligations online with the Tax Office. The account will be occupied with your previous year’s return and any information supplied from your bank, workplace, government companies, etc. The Tax Workplace collects this info up until the beginning of August, so you’ll want to wait until after that to lodge online.
14. Comply with the Rules
Paying tax obligations can, without a doubt, be an excruciating experience, but fudging the numbers and breaking the regulations will set you up for a problem down the road. Taxpayers who have tried to make reductions that didn’t have gotten into warm water with the ATO. The ATO will examine hugely, as well as often small, tax deduction claims that appear dubious.
15. Use a Tax Representative
An expert tax agent can save you a lot of time when it comes to lodging your taxes. They additionally have inside knowledge and market competence on taxes and also refunds. By hiring a tax obligation representative to aid you with your tax obligations, you’ll get the largest tax refund feasible without running afoul of the ATO.
If you’re finding out more concerning credit rating repair work and attempting to lower financial obligation, lowering your taxable income and getting a reimbursement to come tax obligation time can keep more money in your account. Rather than giving that money to the taxman because you didn’t know what deductions you might take, you can make use of that refund to pay off debts and restore your credit scores faster.
You’re guaranteed two points in life– death and taxes. While dealing with your physical and mental health and wellness can result in a longer, much healthier life, economic planning and strategising can lower your tax obligations. Everyone intends to pay much less come tax time. For those who’re exploring financial obligation combination and credit report repair services, finding out exactly how to lower your taxable income can keep even more cash in your pocket and help you pay off your financial obligations quicker. Our list of 15 very easy ways to reduce your taxable income in Australia can help. | <urn:uuid:7b90246b-4a6e-49b3-beb6-e7f95c0ad483> | CC-MAIN-2022-33 | https://mickysays.com/15-easy-ways-to-decrease-your-taxable-income-in-australia/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.96252 | 2,793 | 1.617188 | 2 |
Contemporary Fixed Prosthodontics, 5th Edition
- Follows ADEA curriculum guidelines for fixed prosthodontics
- Features hundreds of step-by-step procedures
- Integrates basic science with clinical applications
- End-of-chapter glossaries consistent with the most recent edition of The Glossary of Prosthodontic Terms (see above)
- Text boxes scattered throughout present quick facts and tips about selected artwork
- Selected key terms presented at the beginning of each chapter and set in bold type within the text facilitates rapid information retrieval
- Essay format study questions offer the reader an opportunity to test his or her knowledge and comprehension after reading each chapter
- Updated references support concepts presented in each chapter.
- Valuable appendices on dental materials/equipment and manufacturers.
- 15 contributors collaborate with the editors to present up-to-date information and state-of-the-art techniques in prosthodontics.
Find practical step-by-step guidelines to hundreds of fixed prosthodontics procedures! Contemporary Fixed Prosthodontics, 5th Edition provides a strong foundation in basic science along with clear descriptions of clinical applications. Using more than 3,000 high-quality drawings and photographs, this reference covers everything from tooth preparation to prostheses and restorations to follow-up care. New to this edition is a chapter on periodontal considerations plus new sections on topics such as cone beam imaging and virtual articulators. From respected prosthodontics educators and clinicians Stephen Rosenstiel, Martin Land, and Junhei Fujimoto, Contemporary Fixed Prosthodontics includes separate sections covering planning and preparation, clinical procedures, and laboratory procedures, making it easier to look up the information you need.
- Illustrated, full-color step-by-step procedures walk you through all the steps of treatment from the beginning to the final treatment result.
- Summary charts provide a quick, at-glance review of specific procedures (such as Class II inlay preparation and all-ceramic crown preparation), highlighting the indications, contraindications, advantages, disadvantages, preparation steps, recommended armamentarium, and criteria.
- Prosthodontic Diagnostic Index helps you determine the appropriate treatments for completely edentulous, partially edentulous, and dentate patients, using guidelines and illustrations from the American College of Prosthodontists.
- Text boxes accompany selected illustrations, presenting quick facts and tips relating to techniques or concepts.
- Study questions offer an opportunity to test your knowledge and comprehension at the end of each chapter.
- Useful appendices list dental materials, equipment, and manufacturers.
|Author Information||By Stephen F. Rosenstiel, BDS, MSD, Professor Emeritus, Restorative and Prosthetic Dentistry The Ohio State University College of Dentistry Columbus OH ; Martin F. Land, DDS, MSD, Professor of Fixed Prosthodontics Department of Restorative Dentistry Southern Illinois University School of Dental Medicine Alton, IL and Junhei Fujimoto, DDS, MSD, DDSc, Part-Time Lecturer, Tokyo Medical and Dental University, Director of J. F. Occlusion and Prosthodontic, Postgraduate Course, Private Practice, Tokyo, Japan|
|Table of Content||PART 1: PLANNING AND PREPARATION
1. History Taking and Clinical Examination
2. Diagnostic Casts and Related Procedures
3. Treatment Planning
4. Principles of Occlusion
5. Periodontal Considerations
6. Mouth Preparation
PART 2: CLINICAL PROCEDURES: SECTION 1
7. Principles of Tooth Preparation
8. The Complete Cast Crown Preparation
9. The Metal-Ceramic Crown Preparation
10. The Partial Veneer Crown, Inlay, and Onlay Preparations
11. Tooth Preparation for All-Ceramic Restorations
12. Restoration of the Endodontically Treated Tooth
13. Implant-Supported Fixed Prostheses
14. Tissue Management and Impression Making
15. Interim Fixed Restorations
PART 3: LABORATORY PROCEDURES
16. Communicating with the Dental Laboratory
17. Definitive Casts and Dies
18. Wax Patterns
19. Framework Design and Metal Selection for Metal-Ceramic Restorations
20. Pontic Design
21. Retainers for Partial Removable Dental Prostheses
22. Investing and Casting
23. Description of Color, Color-Replication Process, and Esthetics
24. Metal-Ceramic Restorations
25. All-Ceramic Restorations
26. Resin-Bonded Fixed Dental Prostheses
27. Connectors for Partial Fixed Dental Prostheses
28. Finishing the Cast Restoration
PART 4: CLINICAL PROCEDURES: SECTION 2
29. Evaluation, Characterization, and Glazing
30. Luting Agents and Cementation Procedures
31. Postoperative Care
Appendix A: Dental Materials and Equipment Index
Appendix B: Manufacturers' Index (online)
|Trim||276 x 216 (8 1/2 x 10 7/8)|
|Stock Status||In Stock| | <urn:uuid:f0a13ea3-9d7b-40e7-9bcc-36c578de51d5> | CC-MAIN-2022-33 | https://www.store.elsevierhealth.com/asia/contemporary-fixed-prosthodontics-9780323080118.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.773865 | 1,144 | 2.171875 | 2 |
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'The Arctic Icecap is only 1 to 2& of Earth's ice, while the elephant, the Antarctic Icecap, contains about 90 percent of Earth's ice'
By: Marc Morano - Climate DepotSeptember 28, 2012 7:03 AM
« Climate Depot home | <urn:uuid:eeed7ff3-c5c1-4fbe-9017-a745d18ff496> | CC-MAIN-2022-33 | https://www.climatedepot.com/2012/09/28/the-elephant-is-the-antarctic-icecap-while-satellite-data-shows-arctic-ice-has-been-declining-for-last-30-years-the-same-satellite-data-shows-antarctic-ice-has-been-expanding-for-30-years/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.821826 | 79 | 1.96875 | 2 |
(君の膵臓を食べたい – 住野 よる）
This story starts with the funeral of a high school girl, so you know it’s going to be depressing from the beginning. However, preparing the reader at the beginning in some way makes it more light-hearted than if Sumino decided to spring it at the end.
Sakura, a buoyant and outgoing high school girl who is terminally ill, meets an introverted boy, who prefers to live out his life engrossed in novels rather than dealing with the world. They form a deep bond over their shared secret about her illness.
I like that the story involves a lot of daily life activities, such as school, eating, and travel. Not living in Japan myself, it is always fun to read about daily life. Also, the story’s focus on normal activities means there is a lot of every day back and forth conversation, which I enjoy even if it’s just because it’s in Japanese.
The best part of the book was the evolution of the relationship between Sakura and the main character, as well as their individual development. He’s not actually a true hikikomori, as Sakura calls him, although he may be on the path to becoming one. While she, on the other hand, is the kind of person that needs to have others around to realize she’s alive. They begin to learn from one another in a relationship that would have never happened under normal circumstances.
On the audiobook side, there were a couple of things about the recording I want to mention. Sakura calls the narrator nakayoshi-kun, meaning something like, “person I’m close to,” and there is always a pause before the kun. It seems like during the first reading an incorrect name was used, then they went and overlayed the correct name. It makes me wonder what they said before. Also, Sakura’s laugh is quite annoying, but maybe it’s supposed to be that way.
The language is simple, with lots of dialogue, and the story is filled with everyday interactions. This is a great candidate if you are looking to get into your first fiction audiobook in Japanese. | <urn:uuid:c93f906e-0b44-4d45-894b-a3ec60786edd> | CC-MAIN-2022-33 | https://shosetsu.ninja/category/sumino-yoru/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.977248 | 480 | 1.609375 | 2 |
(RxWiki News) Remarkable advancements have been made in the treatment of chronic myeloid leukemia. But the race has not yet been won, according to one of the nation's preeminent experts in the field.
Even a few years ago, being diagnosed with chronic myeloid leukemia (CML) was life-limiting. Today, 90 percent of patients are alive after five years and longer. By contrast, in the 1960s, most people with CML lived only 3-5 years.
But the road to victory against CML is a long and winding one, according to a commentary by Jorge E. Cortes, M.D., chair of the CML Section at The University of Texas MD Anderson Cancer Center.
"Find out about the latest treatments available for CML."
Dr. Cortes writes in the January 23, 2012 issue of the Canadian Medical Association Journal (CMAJ), that while significant progress has been made, CML can't yet be cured in all patients. And this is a challenge that must be address and resolved, he says.
He says the journey to finding a cure is like a marathon. "The past half century has been an extraordinary run that has us on an excellent pace to not only complete the race to a cure, but to do so in record time," Dr. Cortes writes.
Also coming online showing positive results as a first-line therapy for newly diagnosed patients is Bosutinib (SKI-606), currently in clinical trials.
This is an impressive arsenal, but Gleevec offers a favorable outcome in only 60 percent of patients. The second-line therapies - Sprycel and Tasigna - work for about half of the people taking it, and 10-15 percent of them will become resistant to the treatments in time, according to Dr. Cortes.
He urges doctors to ensure that their patients are taking their medications. Dr. Cortes also says more research is needed, and health care professionals need to remain focused on the long-term outlook - and race.
He concludes, "Until all patients with chronic myeloid leukemia can have an optimal quality of life while fighting this disease, our marathon is not over."
Dr. Cortes has received consultancy and research funding from CML drug manufacturers: Bristol-Myers Squibb, Novartis and Pfizer. | <urn:uuid:37b19873-57a5-4acf-89ea-1a94dbab732f> | CC-MAIN-2022-33 | https://www.rxwiki.com/news-article/chronic-myeloid-leukemia-cure-must-remain-research-focus-says-expert | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.960109 | 487 | 2.265625 | 2 |
While the whole world expects it’s wrinkles that age you, it’s actually your face shape that’s making you look older.’ advises Dr Claire Oliver(BDS), Medical Director of multi-award winning Air Aesthetics Clinic. She explains why: “The first thing that our mind assesses when it come to judging the age of a person is the shape of their face. Our faces change with time from a triangle (high cheek bones and defined jaw line) to a square with a heavy jaw line and double chin. The shape of the face is much more important than the lines and folds. In fact, according to recent research we universally recognise as younger, a person who is wrinkly but has a youthful face shape.” The good news is that apart from a lower face lift, for those of us who want to avoid going under the knife there are other treatments out there we can do.”
Indeed, Dr Oliver shares with us the non-surgical lift she recommends to her clients “I continue to be impressed with the results experienced with Ultherapy. A innovative skin-lifting treatment which works at the skin’s foundational layer; the area where plastic surgeons work to perform a face lift. But rather than surgery, it uses high-tech ultrasound energy to stimulate and remodel collagen and tissue to lift and tighten. Ultherapy is the only non-surgical, skin lifting treatment in the world cleared by the FDA so I believe you can be confident you will achieve a firmer look.”
Elastin is the support fibre in the body that allows skin to “bounce” back into place. Think of elastin as the springs in a mattress and the stuffing between the springs as collagen, along with other elements of the body, such as fat, cartilage, muscle, and so on. When elastin is damaged, the skin begins to sag, just like a mattress begins to sag as its springs get old and damaged. This sagging combined with sun damage can cause crepe paper-like skin.
*Older skin makes almost no elastin.
*Building more collagen helps support skin so that sagging is less apparent. Skin-care products that contain potent anti-oxidants and skin repairing ingredients such as Vitamin A, also called retinol help repair collagen.
*There are no firming or tightening products whose results are remotely similar to those achieved from medical procedures such as dermal fillers, lasers, Ultherapy or cosmetic surgery. | <urn:uuid:aa39f040-f2cc-471c-ad4f-92ece3ee3e05> | CC-MAIN-2022-33 | https://www.airaesthetics.co.uk/is-it-wrinkles-that-age-you/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.953827 | 530 | 1.578125 | 2 |
New York State recently adopted long-awaited air pollution regulations aimed at small distributed generators. The emissions rules, found in Part 222 of Title 6 of the New York Code of Rules and Regulations (commonly known as “Part 222”), will help to reduce the negative health impacts of nitrous oxide (NOx) and particulate matter (PM) emissions, and will cover small generators that were previously unregulated thanks to a “regulatory gap” in the existing air pollution rules.
Pace participated throughout the regulatory process and filed comments on the proposed rules with our partners in the Clean Energy Organizations Collaborative. Part 222 was championed by Governor Cuomo and represents an important step forward in New York’s effort to mitigate the harmful effects of air pollution.
Generators with a maximum mechanical output rating of 200 horsepower or greater in the New York City Metropolitan Area (NYMA), and 400 horsepower or greater in the rest of the state are covered by the new rules. The more stringent application in NYMA reflects downstate New York’s greater population density, where more people are at risk of asthma and other health conditions caused, or exacerbated, by air pollution, and where low-income residents already face some of the state’s worst air quality.
Part 222 is especially timely in light of New York’s Reforming the Energy Vision proceeding, which is expected to encourage customers to manage their energy usage through a variety of “distributed energy resources,” including the types of diesel-fired generators covered by the rules.
The rules enter into effect in 2017. | <urn:uuid:e199d37b-ccf8-4699-ae9e-8d172965c795> | CC-MAIN-2022-33 | https://energy.pace.edu/2016/12/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.94394 | 324 | 2.578125 | 3 |
How to Handle
Credit Card Debt
It's easy to get in debt over your head.
Having too many credit
cards can lead to overspending.
If you limit the number of cards and set a limit on each card, you
can control spending and avoid excessive debt. Carry just one or two
and return all unwanted cards. Or, do away with all your high
interest cards and obtain a credit card consolidation loan to lower
your monthly payment and keep just one card for emergencies.
If your objective is: to reduce interest rates and lower your
monthly payments, avoid bankruptcy, consolidate your bills to have
one monthly payment, or simply get out of debt the fastest way
possible, credit card debt consolidation can help you achieve your
goal and save thousands of dollars at the same time.
Here are 3 ways to go about lowering your credit card debt.
1) Pay down your highest interest debts first. Avoid making more
credit purchases while paying down your debt. Pay the maximum
possible toward your highest interest debt, not your highest
balance. This method allows you to pay down your
debts at the lowest cost.
2) Low interest rate cards can be used as a tool to reduce credit
card balances systematically to get out of debt. In certain
situations it is wise to transfer balances from high interest cards
to new credit cards with low introductory rates, this is known as
card surfing. Apply for a lower interest rate card with an
opportunity to transfer your balances from current high interest
cards. Start paying down your new consolidated balances, doubling
the minimum payment you were paying on the old balances. It is
crucial that you take advantage of the lower interest rate to pay
more each month to reduce your total debt. When the lower initial
rate is about to increase, you can move to another lower rate card,
if one is offered to you. This is one way you can use credit card
debt consolidation but it is trickier and you really have to know
your interest rates.
3) Talk to your own bank. As a way for banks to get, or keep, your
business, they sometimes offer a balance transfer. This process
means that the bank will take your existing credit card balance and
transfer it to their credit card. Many times they will offer you a
lower rate as an incentive to do so. But remember to close out the
credit card that you transferred the balance from.
The interest rate should be less than what you are currently paying
on your credit cards. However, you may be able to negotiate an even
lower interest rate if you do all your financial banking at the same
place you are applying for a credit card consolidation loan.
As a summary, reduce your number of credit cards to one or two,
change your buying habits, consolidate your debt to a lower interest
rate, and pay a little more than the minimum payment each month so
you can pay off that credit card faster and enjoy being debt free.
About The Author
Paul Sauder is a successful
freelance writer providing helpful tips and advice for consumers on
second mortgages and
equity loans. His many years of
mortgage industry experience have helped others understand the
This article from "articles
for free" is reprinted with permission.
2004 - Articles-For-Free.com | <urn:uuid:09564d96-c8db-4ff8-9389-31573b390525> | CC-MAIN-2022-33 | http://www.buystoneharbor.com/Credit%20Card%20Debt.htm | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882572043.2/warc/CC-MAIN-20220814143522-20220814173522-00472.warc.gz | en | 0.942678 | 713 | 1.726563 | 2 |
Background Germinal Centers (GC) are short-lived micro-anatomical structures, within lymphoid organs, where affinity maturation is initiated. be the area of the segmentation region for the is much larger than (or vice-versa) or because, suddenly, due to the disappearance of the contour at slice grows to very large values, thereby penalizing (or are very similar) then is a nonlinear multidimensional function with many local minimima, many of which are not ideal solutions. In order to understand the behavior of as a function of and (red curve), and (green curve). As can be seen, in both planes, the function experiences a dramatic global minimum for the optimal solution. Figure 7 Ground truth comparisons. (a) Two hyperplane cuts of the multidimensional objective function (red curve) … From this objective function, we use a simulated annealing algorithm that efficiently samples the space of all possible in order to find the optimal set of input parameters,
, given by:
In order to show how robuts our optimization algorithm is with respect to the choice of initial input parameters, Figure 7(b) shows the difference in accumulated area (which is related to the GC volume) between the calculated and ground truth value for Rabbit polyclonal to DUSP22 several iterations of the algorithm for three separate initial values of . In these studies, the ground truth determination was obtained from manual inspection by an expert. Figure Figure 7(c) shows a comparison, superposed on a particular Germinal Center image, between borders obtained with optimal parameter solution, *, using our algorithm and the ground truth border obtained by manual determination. Since the original findspot algorithm finds all contiguous clusters of pixels throughout a volume, connected regions can be filled with holes. By using a convex hull algorithm, or more sophisticated computational geometry algorithms based upon alpha shapes, we can represent and visualize the 3-dimensional GC volumes with the outer bounding surface. Nearby artifacts due to outliers points may be present, distorting the volume estimate, and should be corrected. We eliminate outliers by a simple heuristic algorithm that 131436-22-1 manufacture determines the full distance matrix between all points on the contour and determines whether the distance between each point and all others is greater than 2 value of all other inter point distances (where is the standard deviation). Conversely, we can find the geometric center and determine whether a point is 2 from that center. Optimal stitching Our software pyBioImage also contains a module for automatic stitching of multi-dimensional images, similar to that found in ImageJ. Side-by-side z-stack images of draining lymph nodes were acquired to allow 3D reconstructions of larger organ areas. Due to the large amount of image stacks, we developed our own software algorithms that used information from the microscope position and accelerated the task of forming large image mosaics, referred to as image stitching, from adjacent z-stacks acquisitions. For matching adjacent image stacks, our algorithm uses a fast implementation of the Fourier phase correlation technique for achieving image registration at the borders of adjacent (and overlapping) images. For blending adjacent images, we use a nonlinear pyramid scheme together with pixel intensity scaling for matching potential differences in acquisition exposures. The implementation of our algorithm is available in our cross-platform pyBioImage package, available at the public repository (sourceforge.net/projects/pybioimage/). Information about the installation, documentation, and other software modules 131436-22-1 manufacture (whose description is beyond the scope of this paper), can also be found in the package distribution. 3D reconstructionAnother capability of the ExtractGC module 131436-22-1 manufacture is the ability to accurately visualize the GC volumes in 3D. The reconstruction of the set of borders pixels obtained from each z-stack slice is used for constructing an isosurface with a computational geometry algorithm, called Powercrust, described by Amenta, Choi and Kolluri [28,29]. We have provided a full set of python bindings to the original open-source C-language implementation of these authors in order to easily expose the core algorithm to our application, pyBioImage. The output of powercrust, with the points obtained from the findSpot algorithm in the. | <urn:uuid:11c55018-a3d7-498f-a5a0-43b440ac344e> | CC-MAIN-2022-33 | http://treeoflife-medicinals.com/background-germinal-centers-gc-are-short-lived-micro-anatomical-structures-within-lymphoid-organs/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.893806 | 879 | 2.609375 | 3 |
On December 4, 2016 Italy held a constitutional referendum on an extensive reform of the Senate and the competencies of the regions proposed by Matteo Renzi, then head of the government. Following a sound defeat, where the reform was rejected with 59.11% of the votes against and only 40.89% in favour, Renzi announced his resignation.
At a first glance from afar this may seem another referendum of a 2016 wave where electoral bodies pronounce against their own current establishment and against the European Union. Yet, even though Eurosceptic forces see it as a legitimation of their claims, some considerations hint that it may not be a 60% made of Eurosceptics and there may be deeper and older divides, and Renzi put himself inside it. Furthermore, while the supporters had likely a genuine intent, some parts of the proposed reform raised much concern.
The nature of the rejection
The question was only loosely linked with the EU and was much more about how internal power is divided within the country. This holds true not only as a matter of fact, but also as a matter of the way the referendum was perceived by the voters. For instance, if the EU was seen as a major concern of the question, those traditionally Europhile regions, where European relations are an essential cornerstone of public life, like former 1914 Austria-Hungary, would have voted similarly. Yet, South Tyrol, the province with a German-speaking majority, supported the reform with 63.7% ( http://www.repubblica.it/static/speciale/2016/referendum/costituzionale/province/bolzano_bozen.html ), whereas Friuli-Venezia Giulia, whose capital is Trieste, once a powerhouse of Austria-Hungary and its internationalism, where Slovene-speaking and German-speaking minorities reside, voted with 61% against the proposed reform.
Moreover, it could not be deemed as an anti-establishment revolt like the Trump election. Italy already disbanded its rooted post-war political parties between scandals and electoral defeats in the early 1990s, let Berlusconi fill the void and rise to power and then pronounced him guilty, thus making him unable to run for office due to his conviction. All the current parties rely on a weak equilibrium and seeing them as invincible or even long established electoral forces bears little sense. In addition, Renzi portrays himself as an outsider to politics, an anti-establishment demolitionist (rottamatore) in his own words; he originally obtained power against the establishment of his own party, when former secretary Bersani was not able to form a government after winning only one house of the parliament in 2013. This original power shift could also be one of the reasons behind the fact that half of the Democratic Party was against the proposed reform, despite agreeing on every other single issue brought up by Renzi’s government.
Renzi reached remarkable results in a thousand days, most notably with laws on civil unions and on consensual divorce, as well as stopped the recession trend of Italian economy, despite reaching only a 0.8% growth in 2015. However, his leadership was contested, as he made many cheap electoral promises without a long term gain, such as an €80 tax discount, a €500 bonus for 18-year-old students to be spent on cultural initiatives and museums, and a similar one for public school teachers. He was unable to cut enough of the public debt and he was not doing enough compromising with the constitutional reform. He likely thought that linking the constitutional reform with his own government achievements would have helped him win the referendum without compromising.
However, a common theme of the No side was this proposed uncompromising constitutional architecture that sounded to them not unreasonably as a power grab by Renzi. Together with a two-round electoral system for the Chamber of Deputies that he approved in 2015, the constitutional changes would have granted a majority in the lower house to a sole party that then would have been able to form a government alone, given that the reform proposed a single confidence by the lower house for the government. This “winner takes all” approach that followed Renzi’s mantra “elections do have clear winners”, clashes vehemently with the idea of democracy, as participation and collegiality that surrounds the Constitution and is still widespread and perceived by the people as a bulwark against dictatorialness and one single man politics – such as the ones of Renzi or Berlusconi. Tying this reform with the very governmental politics of Renzi – who portrays himself as the one who fixed the republic unlike the others – served the result to the believer of the single man politics.
So, the picture of Italy this referendum offers is one attached to an idealized past with an antifascist superior moral legitimacy, but with absolutely no clear idea for the future or at least, not a clear idea of the future sufficiently shared among the population to be received by any major political organization. The fall of communism and the scandals of the early 1990s eliminated both the Italian Communist Party and Christian Democracy from the Italian political scene and replaced their respective utopian dreams – or, in a sense, both equally dystopian nightmares – that animated the society with substantially nothing, but political strategy and personal gain. This short-sightedness in itself seems enough to cause a constitutional deadlock: Italy does not see a clear project for the future in any political proposal, but just partisan or even personal gains, hence does not entrust itself easily any more to the political class of representative democracy.
What happens next?
There are some proposals yet to debate from Renzi’s government, such as the debated legalization of cannabis or the many expensive promises that Renzi made, that will probably be now all ignored: the parliament will focus on producing an electoral law for the Senate and possibly for the Chamber of Deputies, meanwhile a weak and short-lived government will be appointed to deal with these issues.
The previous electoral law for both the Senate and the Chamber of Deputies, nicknamed Porcellum, a product of Berlusconi’s government in 2005, was deemed unconstitutional in 2014 and replaced with proportional representation. Later, Renzi had the parliament approve a two-round system – nicknamed Italicum – for the Chamber of Deputies that would grant a majority to the party who wins the second round, but did not enact any such law for the Senate, under the assumption that it would not have been necessary within the framework of his proposed constitutional reform. Following an appeal, this same Italicum will be reviewed for constitutionality in January 2017 by the Constitutional Court.
However, the state of things makes the parliament worry about creating another electoral law:
- The fact that the polls continuously claim that any kind of second round would be won by the Eurosceptic Five Star Movement (M5S) clashes with the parliament’s desire that such winner shall not be them, in order not to jeopardize Italian situation giving an anti-Euro force a majority in a house;
- The fact that a proportional representation for the Senate and Italicum for the Chamber of Deputies may in principle and in opinion polls produce two different majorities in the two houses clashes with the unwillingness of the political forces to form coalitions to govern;
- Renzi’s idea that parliamentary election has to produce clear winners that then govern clashes with the fact that Italy is currently tri-polar (Democrats, M5S, Berlusconi-Northern League), thus it is difficult to produce clear winners in a house with proportional representation.
Such a new law will not be easy to create, as the constitutional court judges already declared Porcellum unconstitutional due to the excessive discrepancy with the popular vote that it generates and they are likely to follow this doctrine again. Therefore, any new electoral law will be free to ignore popular vote representation, while trying to fulfil the wishes of the parliament or play dirty: ignore the court’s doctrine and be quick enough to enact the law and hold elections before the court pronounces it unconstitutional again, then gaining another full legislature to think on the problem.
Anyway, this electoral work is likely to be difficult and probably could be easily solved if the Italian second republic had more willingness to compromise and form grand governing coalitions, like the first republic or just like some of its neighbours. Meanwhile, such a focus on the electoral system diverts attention away from the economic problems of the country, undermining even further the support to the parliament, thus bolstering the support for Eurosceptic forces. | <urn:uuid:24a5e5b9-4075-4fab-9bfb-84249c676e93> | CC-MAIN-2022-33 | https://theeuropeannetwork.eu/a-nation-that-does-not-want-to-know-what-she-wants-to-be-when-she-grows-up-2/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571950.76/warc/CC-MAIN-20220813111851-20220813141851-00672.warc.gz | en | 0.972206 | 1,747 | 2.125 | 2 |
CSIS Releases September 2018 Issue Of Global Health Policy Center Monthly Newsletter
Center for Strategic & International Studies: Global Health Policy Center Monthly Newsletter: September 2018
In the September 2018 CSIS Global Health Policy Center Newsletter, J. Stephen Morrison, senior vice president and director of the CSIS Global Health Policy Center, highlights publications, podcasts, and past and upcoming events hosted by CSIS. The newsletter includes links to a brief written by Morrison reflecting on this year’s International AIDS Conference in Amsterdam; a podcast episode hosted by Sara Allinder, deputy director and senior fellow at the CSIS Global Health Policy Center, who speaks with Farhana Amanullah, pediatric TB expert at the Indus Hospital Karachi in Pakistan, about the challenges of addressing pediatric tuberculosis in low- and middle-income countries; and a podcast episode hosted by Nellie Bristol, senior fellow at the CSIS Global Health Policy Center, who speaks with Mike McGovern, chair of Rotary’s PolioPlus Committee, about Rotary International’s role in global polio eradication (September 2018).
The KFF Daily Global Health Policy Report summarized news and information on global health policy from hundreds of sources, from May 2009 through December 2020. All summaries are archived and available via search. | <urn:uuid:b2257fd5-5211-49dc-9af4-bddf841c3862> | CC-MAIN-2022-33 | https://www.kff.org/news-summary/csis-releases-september-2018-issue-of-global-health-policy-center-monthly-newsletter/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.907427 | 257 | 1.6875 | 2 |
Are the leaves starting to change where you live? We are just starting to move into color season here. Make sure your family doesn’t miss out on any of the beauty that autumn has to offer by using my free fall scavenger hunt. You can play together because when you spend time outside in fall, no matter who fills his card first, you all win!
FREE FALL SCAVENGER HUNT
DOWNLOADING THE PRINTABLE
I am so excited to share these printables with you for free! To access the printables, sign up for a Mad in Crafts Freebies Membership using the form above or by signing up HERE. Don’t worry, the membership won’t cost you a penny, but it WILL give you access to all of the freebies I have shared here on Mad in Crafts.
Once you are logged into the Freebie Gallery, you will find this fall scavenger hunt printable in the Fall section of the gallery.
HOW TO USE THE SCAVENGER HUNT
Your family can come up with your own rules for how you play the scavenger hunt. If you want to up the difficulty level, you can take a nature walk and see how items you can see during that one walk. Spread out the fun by playing over the course of a few weeks to see if you find all twenty items. If you live in an area where the leaves don’t change colors, feel free to allow your kids to look for the items in books or TV shows! There is no wrong way to play the game.
Determine a fun prize for the person who finds the most scavenger hunt items. I am partial to cider and donuts, but any fall treat or activity would be a great prize! | <urn:uuid:ac6cfefb-dc0c-4726-936c-dc451f3764f4> | CC-MAIN-2022-33 | https://madincrafts.com/free-fall-scavenger-hunt/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.926638 | 365 | 1.796875 | 2 |
Column: Sports are full of opportunity
Published 9:00 am Saturday, March 20, 2021
Watching Drew Brees throw perfect spirals to his kids in the end zone after losing to Tampa Bay in the playoffs I knew his career as a Saint was more than likely done.
Over his career, Brees has given his time, energy and resources to the city of New Orleans and the State of Louisiana. His non-profit work includes the dream foundation whose Mission is to “improve the quality of life for cancer patients, and provide care, education and opportunities for children and families in need.” according to the foundation’s website.
In his retirement announcement, his kids yelled the big news as their dad was finally going to be able to spend more time with them. In the same post he announces he will stay in New Orleans because he has more work to do, he said.
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I’m sure he will continue to work with charities now he is retired, but as a father he will be able to spend more time with his kids. They are reaching the age where he will want to be in the stands for them, he will want to be there with them every second he can to grow closer to them.
Something fascinating about sports and the outdoors is how parents and older generations pass on their knowledge to the next generation. It is why I cannot help but smile when I see a father play catch with his son, or a mom kick a ball back to her daughter. Anytime an adult takes the time out of their day to show the ropes to the young and inexperienced is a great thing.
This last weekend parents stood and watched as the next generation of outdoorsman and shooters blasted clay pigeons out of the sky in Adams County. I tried to soak it all in, observing the interaction between mentors and mentees it is encouraging to see because knowledge was being shared and passed on.
It would be selfish of anyone to ask Drew Brees for another year away from his kids. After all, maybe one of them will grow up to be like their dad, a prolific quarterback but an even better person.
For Drew Brees, athletics have provided him an opportunity to give more than himself. For others sports allow for the passing on of wisdom and life lessons. Others use sports as a ministry opportunity, which is great. We all have a day when our sports careers are over, but fortunately, we still have the opportunity to give back.
Speaking of opportunity, The Natchez Democrat is seeking individuals who can take photographs and write stories to help with sports coverage in the Miss-Lou region.
If you have a passion for sports and enjoy writing and photography this is a great chance to serve the community by highlighting the athletes who compete here.
If you are interested ,please contact the sports department at firstname.lastname@example.org. | <urn:uuid:5baa80b7-3b44-461f-baf6-cc0e402bb5ea> | CC-MAIN-2022-33 | https://www.natchezdemocrat.com/2021/03/20/column-sports-are-full-of-opportunity/ | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573744.90/warc/CC-MAIN-20220819161440-20220819191440-00472.warc.gz | en | 0.981511 | 590 | 1.554688 | 2 |
Is alum water bad for hair?
Yes, you can colour your hair easily at home using alum, which is essentially a chemical compound found in many minerals. It can be easily purchased in the market. … Apply this paste on the hair and let it dry, after which you can wash it off with normal water.
Does alum affect hair growth?
A mixture of alum powder and water or better still rosewater can be applied all over the face and body. This paste tends to retard the body hair growth over time. … Since alum is a mild abrasive, when we rub it gently on the face, it weakens the hair roots.
What is the side effects of alum?
If experienced, these tend to have a Severe expression i
- fluid accumulation around the eye.
- throat swelling.
- a feeling of throat tightness.
- a skin ulcer.
- a shallow ulcer on the skin.
- puffy face from water retention.
Does Fitkari reduce hair growth?
For Hair Removal
You must be shocked at the moment, but this is true. In ancient times women used to use phitkari paste for the Removal of unwanted hair. … You can use this paste after waxing or threading as phitkari helps reduce or slow hair growth.
How can I stop hair fall immediately?
This article contains several tips for preventing hair loss and ways to regrow hair.
- Eating extra protein. …
- Trying a scalp massage. …
- Taking hair loss medication. …
- Trying low-level light therapy. …
- Maintaining good hair and scalp care. …
- Using onion juice on the scalp. …
- Why hair falls out.
How can be stop hair fall?
You can follow a few hair hygiene tips to make your hair less likely to fall out.
- Avoid hairstyles that pull on the hair.
- Avoid high-heat hair styling tools.
- Don’t chemically treat or bleach your hair.
- Use a shampoo that’s mild and suited for your hair.
- Use a soft brush made from natural fibers. …
- Try low-level light therapy.
How do you permanently remove hair with alum?
Take a little bit of alum, one tbsp of rose water and one tbsp of olive oil. Mix all – make sure that alum (turn it into a powder) dissolves in the rose water. Apply on affected areas with a cotton ball. Wait till it dries off completely.
How do you stop body hair from growing permanently?
The following methods are ranked by their ability to remove hair for the longest amount of time.
- Electrolysis. …
- Laser hair removal. …
- Prescription creams. …
- Professional tweezing and waxing. …
- Chemical depilation.
Does alum remove hair permanently Quora?
Yes, it is known for reducing facial hair; it’s been used traditionally by women to permanently remove their upper lip hair. You should use it daily on wet face and let it sit for 20 mins. Then wash it off. It’s a long procedure though: it will take 2–3 months to notice changes.
Is it safe to drink Fitkari water?
Do not drink it: as it can make you nauseous. For bleeding gums, weak teeth, and dental caries: Make a paste of one gram of alum, a pinch of cinnamon and some rock salt. Gently massage this on the gums and then wash the mouth.
Can I use alum daily on face?
You can use it on your face once or twice daily, after gently cleansing the skin.
Is Fitkari poisonous?
Alum, or Phitkari, is an acceptable white-coloured salt-like substance. It is a combination of aluminium sulfate and potassium sulfate. Alum (aluminium sulfate) is a nontoxic liquid mainly used in water purification treatment to clarify drinking water crystalline in nature.
How can I remove facial hair permanently?
The only advanced technique for hair removal that can permanently remove facial hair is electrolysis. Electrolysis involves using an electric current to permanently destroy the hair follicle. If you have excessive facial hair growth, you must consult your doctor.
How can I remove unwanted hair permanently at home?
Start with mixing two tablespoons of sugar and lemon juice, and one tablespoon of honey. Heat the mixture for about three minutes and add water to make the mixture thinner, if required. Once the paste cools down, apply cornstarch on the affected areas and spread the paste in the direction of hair growth.
Can I leave alum on face overnight?
The Alum Block will dry the skin and spots leading to a better appearance. Alternatively, apply to spots and pimples last thing at night. Don’t use the Alum stone on the face more than twice daily as it could lead to the skin over-compensating by producing more oil. | <urn:uuid:479e2237-dd67-4a1f-a4df-a1779fd59891> | CC-MAIN-2022-33 | https://fashionsensored.com/alopecia/quick-answer-does-alum-water-cause-hair-fall.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.911718 | 1,055 | 1.898438 | 2 |
The necessity of mineral in the body is very vital as it helps in maintaining a sound health and body growth. Better availability of minerals in the body helps in proper development and removes severe diseases and health related issues. Better mineral availability helps in better metabolic activity and stimulation of different organ to perform better. These minerals are gained by the feed which camel eats. With the proper digestion of the feed in the rumen helps in the extraction of vital minerals and nutrients of the feed and get it absorbed in the rumen for the better health. But along with the feed there is a need of external trace mineral supplement which helps in fulfilling the mineral requirement to the body. Some of the major mineral supplement that are vitally required are selenium, Zinc, calcium, sodium, phosphorus and iodine which prevents the body from any deformities and diseases. Anfaboost ATM Pro, is a widely used trace mineral supplement which is used among camels for removing the mineral deficiency and promoting better health. This vital feed supplement consists of vital available minerals like cobalt, copper, iodine, iron, magnesium etc which achieve better metabolic and stimulating action in body and organs for a better health and body development. ATM Pro offers superior bioavailability of trace minerals and is stable in presence of other chelating agents.
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Each Course, Continuously for 7-10 Days.
Or, as advised by veterinarian consultants. | <urn:uuid:c8273fab-61d9-40cc-8dd3-09c602949737> | CC-MAIN-2022-33 | http://www.livestocknutrition.in/camel-trace-mineral.html | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571584.72/warc/CC-MAIN-20220812045352-20220812075352-00672.warc.gz | en | 0.919796 | 338 | 1.671875 | 2 |
The bridge saw is a great piece of heavy machinery that can do many different types of work. However, it is not suitable for cutting hard materials and if you are new to construction or building projects, it may be best to use a more traditional machine that can accomplish the same tasks. When choosing a bridge saw infrared stone cutting machine, there are many different models from which to choose. Regardless of what type of job you need this machine to perform, it can be purchased at a local retailer or on the Internet.
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If you’re a leader, you’ve likely heard of Amazon’s 14 leadership principles. If you haven’t, now’s the time to the look into it. What exactly can you learn from those leadership principles? A lot.
It’s difficult to go wrong with being a leader who is obsessed over customers, thinking long-term, and embracing new challenges even if the task isn’t “their job,” finding ways to simplify, recognizing talent and developing them, along with thinking big.
What if I told you these qualities are only a handful of principles implemented by Amazon. Clearly, Amazon isn’t your average organization, especially in what they do best: lead. No wonder the Wall Street Journal has labeled Amazon America’s CEO factory
Forbes contributor Peter Cohan believes that Amazon is the world’s best business. He goes further and states that “Amazon has a sustainable competitive advantage.” Amazon has an efficient supply chain able to handle and fulfill orders with ease yet maintains a stellar level of customer support, he adds.
Remarkable, isn’t it?
Associate Editor for the Leader To Leader magazine, Peter Economy, goes further to say that Amazon’s 14 leadership principles can help a business to achieve remarkable success because Amazon’s DNA has a desire to innovate and deliver results and earn customer trust in the process.
In this article, you will learn how leaders can leverage Amazon’s 14 leadership principles to become better leaders themselves and act as a catalyst in their organization.
What Are Amazon’s 14 Leadership Principles?
According to Amazon’s website, they are:
1. Customer Obsession
Amazon pays attention to other retailers, but they obsess over their customers. Customer trust is important to Amazon’s leadership.
Amazon encourages its employees to act like leaders. The team needs come second to the needs of the organization at large.
3. Invent and Simplify
It’s an expectation for Amazon employees to invent and simplify. Being misunderstood is part of the process of greatness for them.
4. Are Right a Lot
Amazon looks to hire leaders with diverse perspectives, with good judgement and instincts.
5. Learn and Be Curious
Improvement and exploration is encouraged.
6. Hire and Develop the Best
In short, Amazon recognizes exceptional talent and creates mechanisms to discover the very best.
7. Insist on the Highest Standards
Amazon insists on continuously raising the bar in order to achieve a sustainable degree of excellence. Problems are solved ahead of time and are rarely repeated.
8. Think Big
Leaders are encouraged to create and think outside the box.
9. Bias for Action
Risk-taking and speed is encouraged by leaders at Amazon.
Accomplishing more with less is Amazon’s way of constantly reinventing their operation and increasing their rates of self-sufficiency.
11. Earn Trust
Treating others with respect, speaking their minds, and listening are three ways in which Amazon builds trust in their organization.
12. Dive Deep
Amazon’s leaders are detail oriented and pay close attention to the reaction between the actual numbers and anecdotal data.
13. Have Backbone; Disagree and Commit
Disagreement is welcomed. Social cohesion isn’t a practice that Amazon leaders adopt.
14. Deliver Results
Amazon leaders are expected to always rise to the occasion.
How to Put the Leadership Principles into Practice
In order to develop your leadership skills, experiment with the following combination of Amazon principles and pay attention to which one works best for you in your organization.
1. Think Big, Create, and Simplify
Albert Einstein once said, “Creativity is more important than knowledge.”
When I served as an Interim Department Chair at Jackson State University, we were able to create a document arguing for why the department needed to be a school of journalism and media studies in the state through a “think big” mentality and simplification of delivery. We made it simple for the Institutions of Higher Learning (IHL) of Mississippi, which is the governing body that approves and rejects proposals for turning departments into schools and more, to understand our petition by taking out language complexity yet showing a bold proposal for the creation of the third school of journalism.
Six months after our petition was submitted to IHL, the department was approved to start operations as a “school” by the organization. By thinking big and creating a simple yet persuasive document with hard data proved to be effective in the creation of a new school of journalism in the south.
By applying the same tactics in your organization, you can leverage these principles to achieve your own success and create something new.
2. Invent, Earn Trust, Deliver Results
Great leaders invent, earn trust, and deliver results. Ford invented the assembly line in 1913 and changed the way we produce cars today. Percy Spencer revolutionized our society by introducing the microwave oven in 1946. Jonas Salk invented a vaccine that reduced the number of polio cases in the world from a bit over 28 thousand a year in 1955 to 22 in 2017. More recently, Apple invented a tech gadget that can make phone calls, surf the internet, take photos… they called this device ”the iPhone” in 2007. We can now print in three dimensions with 3D printing, thanks to invention!
It’s no accident that many of us drive Ford cars, have a microwave in our homes, don’t have polio, have an iPhone, and perhaps own a 3D printer. Leaders who invent eventually earn trust if they deliver the results promised. As a leader, you must do the former religiously.
In 2010, my wife and I decided to invent a company called “I Do Therapy.” It is still a company that offers massage therapy services in a post industrial northern town in Pennsylvania. Our actual invention wasn’t the techniques that my wife used to treat clients with head and body aches but a completely new system of customer service that allowed everyone to get a massage for a reasonable price in a luxury spa environment — “I Do Therapy: For EVERYbody.”
Our innovation was our strategy. We invented our way of doing business that was foreign in that town. We ended up earning the trust of a large number of townspeople because we delivered what we promised. Three years after I Do Therapy’s inception and almost 300 clients in our books, we sold the business for a profit in 2015.
The business lives by its name and is still operational to this day.
3. Frugality, Ownership, and Curiosity
Jeff Bezos once said, “Frugality drives innovation just like other constraints do.” I want to start this section with this quote because I’ve seen the former working wonders in a recent organization that I lead here in Tennessee.
Although my presidency at the Cleveland Media Association (CMA) has been cut short due to a recent job offer, CMA is now in much better shape financially because of my insistency on frugality. At the beginning of this year, I inherited an organization with a very low cash position. Under my leadership, the board immediately took a look at our fixed expenses, membership, and resources, and in a semi-crisis mode, we decided to reinvent our operation and cut non-essential expenses in order to bring the organization to a better monetary position.
In a period of a few months, new members joined our organization and old members renewed their yearly memberships. The organization now has a healthy cash position and is growing again. The thought process I used to bring back organizational stability was literally based on Amazon’s 14 leadership principles.
By encouraging an enthusiastic VP and other members of the executive leadership team to be curious about operating to capacity and by looking at CMA as something bigger than ourselves, we found a solution to our financial challenges and helped the organization to get on its feet gain. Through an exploration of possible ideas and curiosity, CMA is a better organization now than yesterday.
We were able to accomplish more with less with our diversity of perspectives.
Amazon didn’t become a Fortune 5 company by accident. The leadership principles introduced by Jeff Bezos has made amazon.com what it is.
“You can’t solve today’s problems with yesterday’s solutions,” said Einstein.
Leaders have much to learn from Amazon. Focusing on the customers’ needs, encouraging invention, creativity and simplification, along with the need to be frugal and develop trust are a must in the current landscape of our modern economy. Thinking big, developing curiosity, and allowing a team member to disagree freely are principles that should be incorporated into every organization.
Higher standards emerge from such principles, and success follows the results. Amazon’s 14 leadership principles will make you into a stronger leader if you take the time to implement them.
More Leadership Tips
- What Makes a Good Leader: 9 Critical Leadership Qualities
- 7 Ways to Improve Your Management Leadership Skills
- Leadership vs Management: Is One Better Than the Other?
Featured photo credit: Perry Grone via unsplash.com
|||^||Wall Street Journal: Amazon Is America’s CEO factory|
|||^||Forbes: 3 Reasons Amazon Is The World’s Best Business|
|||^||Inc magazine: The 14 Amazon Leadership Principles That Can Lead Your Business To Tremendous Success|
|||^||Amazon: Amazon Leadership Principles|
|||^||Wharton Magazine: Learn From Amazon’s Leadership Principles|
|||^||Business News Daily: Albert Einstein Business Tips| | <urn:uuid:a24d3823-43e4-4b5a-8ded-0905a286e884> | CC-MAIN-2022-33 | https://www.lifehack.org/875452/leadership-principles?utm_campaign=Organize.%20Plan.%20Succeed.&utm_medium=email&utm_source=Revue%20newsletter | s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571222.74/warc/CC-MAIN-20220810222056-20220811012056-00672.warc.gz | en | 0.94479 | 2,070 | 1.664063 | 2 |
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