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MED-999 | Polybrominated diphenyl ethers in food and human dietary exposure: a review of the recent scientific literature. | Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants (BFRs) used to protect people from fires by reducing the flammability of combustible materials. In recent years, PBDEs have become widespread environmental pollutants, while body burden in the general population has been increasing. A num... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22100397"
} |
MED-1000 | Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents: a cross-sectional study | Background Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a group of chemicals used in many household and commercial products to prevent fire. Although the first reports of detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sp... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23151181"
} |
MED-1002 | Polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and measures of thyroid function in second trimester pregnant women in California | Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute to adverse neurodevelopmental outcomes. We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE-183 to -209), and h... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21830753"
} |
MED-1003 | In Utero and Childhood Polybrominated Diphenyl Ether (PBDE) Exposures and Neurodevelopment in the CHAMACOS Study | background: California children’s exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs are known endocrine disruptors and neurotoxicants in animals. Objective: Here we investigate the relation of in utero and child PBDE exposure to neurobehavioral development among ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23154064"
} |
MED-1004 | Diet Contributes Significantly to the Body Burden of PBDEs in the General U.S. Population | Background Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. Objectives The primary goal of this research was to evaluate the dietar... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20019900"
} |
MED-1005 | Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis | Objective To determine the effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Medline, Embase, and the Cochrane controlled trials register up to April 2008. Review methods Randomised c... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19008265"
} |
MED-1006 | Treatment of abdominal pain in irritable bowel syndrome. | Functional abdominal pain in the context of irritable bowel syndrome (IBS) is a challenging problem for primary care physicians, gastroenterologists and pain specialists. We review the evidence for the current and future non-pharmacological and pharmacological treatment options targeting the central nervous system and ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24845149"
} |
MED-1007 | Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. | BACKGROUND: The impact of irritable bowel syndrome, a gastrointestinal motility disorder, is underestimated and poorly quantified, as clinicians may see only a minority of sufferers. AIM: To determine the prevalence, symptom patterns and impact of irritable bowel syndrome in the US. METHODS: This two-phase community su... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15932367"
} |
MED-1008 | Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. | INTRODUCTION: The use of peppermint oil in treating the irritable bowel syndrome has been studied with variable results probably due to the presence of patients affected by small intestinal bacterial overgrowth, lactose intolerance or celiac disease that may have symptoms similar to irritable bowel syndrome. AIM: The a... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17420159"
} |
MED-1009 | The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. | Herbal remedies, particularly peppermint, have been reported to be helpful in controlling symptoms of irritable bowel syndrome (IBS). We conducted a randomized double-blind placebo-controlled study on 90 outpatients with IBS. Subjects took one capsule of enteric-coated, delayed-release peppermint oil (Colpermin) or pla... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19507027"
} |
MED-1010 | Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. | BACKGROUND: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was p... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19440080"
} |
MED-1011 | Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome | Background Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive and non-concealed administration) is superior to a no-treatment control with matched patient-provid... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21203519"
} |
MED-1012 | Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. | GOALS: The aim of this study was to assess the efficacy and safety of enteric-coated peppermint oil capsules compared with placebo for the treatment of active irritable bowel syndrome (IBS). BACKGROUND: IBS is a common disorder that is often encountered in clinical practice. Medical interventions are limited and the fo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24100754"
} |
MED-1013 | Quality of life in patients with irritable bowel syndrome. | There has been an underestimation of the impact of irritable bowel syndrome (IBS) on an individual's functioning and quality of life (QoL). The general health status of both young and elderly individuals with IBS is generally found to be poorer than that of the general population. Patients with IBS seem to have worse h... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21666428"
} |
MED-1014 | Medication management of irritable bowel syndrome. | BACKGROUND: Irritable bowel syndrome (IBS) is a complex syndrome that is difficult to manage. Here we present the evidence supporting medication treatments for specific IBS symptoms, discuss evidence-based management of IBS with medications including dose regimens and adverse effects and review progress on research for... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24992947"
} |
MED-1015 | A TREATMENT TRIAL OF ACUPUNCTURE IN IBS PATIENTS | Objective To compare the effects of true and sham acupuncture in relieving symptoms of IBS. Methods A total of 230 adult IBS patients (75% females, average age 38.4 yrs) were randomly assigned to 3 weeks of true or sham acupuncture (6 treatments) following a 3 week ‘run-in’ with sham acupuncture in an ‘augmented’ or ‘l... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19455132"
} |
MED-1016 | Linaclotide (Linzess) for Irritable Bowel syndrome With Constipation and For Chronic Idiopathic Constipation | Linaclotide (Linzess) for irritable bowel syndrome with constipation and for chronic idiopathic constipation. | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23641133"
} |
MED-1017 | Complementary and alternative medicines in irritable bowel syndrome: An integrative view | Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with a high incidence in the general population. The diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific antigens. The current pharmacological treatment approaches avail... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24574705"
} |
MED-1018 | The effect of intensive diabetes treatment on the progression of diabetic retinopathy in insulin-dependent diabetes mellitus. The Diabetes Control ... | OBJECTIVE: To determine the magnitude of the decrease in the risk of retinopathy progression observed with intensive treatment and its relationship to baseline retinopathy severity and duration of follow-up. DESIGN: Randomized clinical trial, with 3 to 9 years of follow-up. SETTING AND PATIENTS: Between 1983 and 1989, ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/7826293"
} |
MED-1019 | Diabetic retinopathy. | Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including strok... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20580421"
} |
MED-1020 | Pan retinal photocoagulation for proliferative diabetic retinopathy: pattern scan laser versus argon laser. | PURPOSE OF REVIEW: Diabetic retinopathy is the leading cause of visual impairment in working-age adults worldwide. Pan retinal photocoagulation (PRP) has provided an effective treatment to decrease the risk of severe vision loss in patients with proliferative diabetic retinopathy for the past four decades. Pattern scan... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24663066"
} |
MED-1021 | Management of diabetic retinopathy: a systematic review. | CONTEXT: Diabetic retinopathy (DR) is the leading cause of blindness in the working-aged population in the United States. There are many new interventions for DR, but evidence to support their use is uncertain. OBJECTIVE: To review the best evidence for primary and secondary intervention in the management of DR, includ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17712074"
} |
MED-1023 | Optimal management of cytomegalovirus retinitis in patients with AIDS | Cytomegalovirus (CMV) retinitis is the most common cause of vision loss in patients with acquired immunodeficiency syndrome (AIDS). CMV retinitis afflicted 25% to 42% of AIDS patients in the pre-highly active antiretroviral therapy (HAART) era, with most vision loss due to macula-involving retinitis or retinal detachme... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20463796"
} |
MED-1025 | How to Interpret a Functional or Motility Test - Defecography | Defecography evaluates in real time the morphology of rectum and anal canal in a physiologic setting by injection of a thick barium paste into the rectum and its subsequent evacuation. Because of its ability of structural and functional evaluation, defecography is primarily performed for work up of patients with longst... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22148112"
} |
MED-1026 | Pressure changes in varicose veins. | Pressures in the superficial leg veins of 24 patients with varicose veins and 6 normal controls were studied. In the controls there was no rise in pressure in the veins on increasing the intra-abdominal pressure, but in the patients with varicose veins pressure rose significantly. Squatting was no better than sitting i... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/56587"
} |
MED-1027 | Varicose Veins, Deep Vein Thrombosis, and Haemorrhoids: Epidemiology and Suggested Aetiology | Current concepts on the aetiology of varicose veins, deep vein thrombosis, and haemorrhoids have been examined and, in the light of epidemiological evidence, found wanting.It is suggested that the fundamental cause of these disorders is faecal arrest which is the result of a low-residue diet. | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/5032782"
} |
MED-1028 | Faecal retention: a common cause in functional bowel disorders, appendicitis and haemorrhoids--with medical and surgical therapy. | The present studies explored whether faecal retention in the colon is a causative factor in functional bowel disease, appendicitis, and haemorrhoids. Faecal retention was characterized by colon transit time (CTT) after radio-opaque marker ingestion and estimation of faecal loading on abdominal radiographs at 48 h and 9... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/25748875"
} |
MED-1029 | Comparison of straining during defecation in three positions: results and implications for human health. | The aim of the study was to compare the straining forces applied when sitting or squatting during defecation. Twenty-eight apparently healthy volunteers (ages 17-66 years) with normal bowel function were asked to use a digital timer to record the net time needed for sensation of satisfactory emptying while defecating i... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12870773"
} |
MED-1030 | Transient changes in cerebral vascular resistance during the Valsalva maneuver in man. | Measurements of cerebral spinal fluid pressure, arterial pressure, and internal carotid artery blood flow were obtained in a series of patients during a Valsalva maneuver. During straining (phase II), an 11% reduction in mean arterial pressure was associated with a 21% decrease in internal carotid flow from control val... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/6229907"
} |
MED-1031 | Primary constipation: an underlying mechanism. | Primary (simple) constipation is a consequence of habitual bowel elimination on common toilet seats. A considerable proportion of the population with normal bowel movement frequency has difficulty emptying their bowels, the principal cause of which is the obstructive nature of the recto-anal angle and its association w... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/2927355"
} |
MED-1032 | Defecation syncope. A symptom with multiple etiologies. | To our knowledge, there is no previous clinical description in the literature of patients with defecation syncope. We evaluated 20 patients with this disorder who were a subgroup of a larger, prospective study of syncope, 13 women and seven men, with a mean age of 59 years. Eleven patients had had one episode and nine ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/3778072"
} |
MED-1033 | "Bowel obsession syndrome" in a patient with chronic constipation. | OBJECTIVE: The bowel obsession syndrome (BOS) is a psychosomatic disorder which often remains at the intersection of somatic and psychological domains without being adequately diagnosed and treated. CASE REPORT: A 32-year-old man with chronic constipation presented with restricted diet, compulsions on evacuation, socia... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22717088"
} |
MED-1034 | Insights Into Normal and Disordered Bowel Habits From Bowel Diaries | Background While symptom questionnaires provide a snapshot of bowel habits, they may not reflect day-to-day variations or the relationship between bowel symptoms and stool form. Aim To assess bowel habits by daily diaries in women with and without functional bowel disorders. Method From a community-based survey among O... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18021288"
} |
MED-1035 | How trustworthy are bowel histories? Comparison of recalled and recorded information. | One hundred and fifty hospital outpatients were questioned about their bowel habits and then asked to record these in diary booklets for two weeks. Overall, recalled and recorded figures for frequency of defecation agreed fairly closely, but in 16% of patients there was a discrepancy of three or more bowel actions per ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/974496"
} |
MED-1036 | The response of the colon to eating. | Much evidence indicates that there is an increased motor activity in the colon from eating in several species of animals. Though some of this effect may be cephalic in origin, the greater part of the response results from the arrival of food in the stomach and proximal intestine. Chemoreceptor stimulation appears to be... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/3933325"
} |
MED-1037 | A brief journey into medical care and disease in ancient Egypt. | Ancient Egypt was one of the greatest civilizations to have arisen, becoming the cradle of scientific enquiry and social development over 3 millennia; undoubtedly its knowledge of medicine has been vastly underestimated. Few artefacts survive which describe the medical organization, but from the extent of the diseases ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/7752157"
} |
MED-1038 | Dietary fiber and personality factors as determinants of stool output. | We examined effects of fiber on stool output, since this is one of the primary mediating variables for the hypothesized relationship between fiber and disease. Total neutral detergent fiber in the dietary fiber source was predictive of stool weight but not frequency. Substantial individual differences in stool output r... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/6269944"
} |
MED-1039 | Bowel obsession syndrome in a patient with ulcerative colitis. | Gastroenterologists are often faced with the diagnostic problem of differentiating acute symptoms of ulcerative colitis from functional intestinal disorders. Bowel obsession syndrome (BOS) is an OCD-like, functional syndrome characterized by fear of fecal incontinence and compulsive behaviors of evacuation-checking. On... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17878507"
} |
MED-1040 | Assessment of normal bowel habits in the general adult population: the Popcol study. | OBJECTIVE: Defining normal stool habit is important when evaluating diarrhoea or constipation, but common confounders such as irritable bowel syndrome (IBS) or the intake of medications with gastrointestinal side effects have not been considered in earlier population based studies defining what is normal. We hypothesiz... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20205503"
} |
MED-1041 | Gastroenterology in ancient Egypt. | Physicians in ancient Egypt devoted their care to disorders of individual organs. Notable among the specialties was gastroenterology, a subject matter that occupied a major portion of the surviving medical papyri. Although they did not name diseases as we know them, Pharaonic physicians described a host of gastroentero... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/2033225"
} |
MED-1042 | Colonic motility in man: features in normal subjects and in patients with chronic idiopathic constipation. | The human colon is still a relatively unknown viscus, especially concerning its motor activity. However, in recent years, techniques have been perfected that allow a better understanding of colonic motility, especially through prolonged recording periods. In this way, it has been demonstrated that the viscus contracts ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10406232"
} |
MED-1045 | Colon cancer and diet, with special reference to intakes of fat and fiber. | Colon cancer, rare in the past, and in developing populations, currently accounts for 2 to 4% of all deaths in Western populations. Evidence suggests the primary cause to be changes in diet, which affect the bowel milieu intérieur. It is possible that in sophisticated populations, the higher concentrations of fecal bil... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/998552"
} |
MED-1046 | Cephalic phase of colonic pressure response to food. | A cephalic phase of colonic pressure response to food was sought in five normal subjects (mean age (22.6) years, 22-24), studied on six separate occasions by recording intraluminal pressures in the unprepared sigmoid colon. Gastric acid secretion was measured simultaneously by continuous aspiration through a nasogastri... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/8491403"
} |
MED-1047 | The development of the concept of dietary fiber in human nutrition. | Fundamental studies of the laxative action of wheat bran were undertaken in the United States in the early decades of the 20th century. Walker in South Africa extended these studies among African blacks and later suggested that cereal fiber protected them against certain metabolic disorders. Trowell in Uganda elaborate... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/707390"
} |
MED-1048 | Defecation frequency and timing, and stool form in the general population: a prospective study. | Because the range of bowel habits and stool types in the community is unknown we questioned 838 men and 1059 women, comprising 72.2% of a random stratified sample of the East Bristol population. Most of them kept records of three consecutive defecations, including stool form on a validated six point scale ranging from ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/1624166"
} |
MED-1049 | Bowel movement: the sixth vital sign. | Bowel movements provide vital information on how the body is functioning, and constipation among older adults is especially problematic. Although we do not like hearing the details of someone else's bowel movement, it is a function that nurses need to assess, support, and treat with the same attitude as when caring for... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24722614"
} |
MED-1050 | The effect of personal lifestyle intervention among health care providers on their patients and clinics; the Promoting Health by Self Experience (P... | OBJECTIVE: To determine the effect of self-experience multidisciplinary lifestyle intervention on health care providers (HCPs), patients and clinics. METHODS: We randomized 15 primary-care clinics (serving 93,821 members), matched by patient profile, to provide the HCPs, either intervention or control HMO program. We f... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22906808"
} |
MED-1051 | How does physician advice influence patient behavior? Evidence for a priming effect. | OBJECTIVE: To explore a potential "priming effect" of physician advice on patient responses to behavioral change interventions. DESIGN: Randomized controlled trial with a 3-month follow-up. SETTING: Four community-based group family medicine clinics in southeastern Missouri. PARTICIPANTS: Adult patients (N = 915). INTE... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10810947"
} |
MED-1053 | Physician disclosure of healthy personal behaviors improves credibility and ability to motivate. | CONTEXT: While some studies have shown that physicians with healthy personal habits are especially likely to discuss prevention with their patients, to our knowledge no one has published information testing whether physician credibility and patient motivation to adopt healthier habits are enhanced by physician's disclo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10728118"
} |
MED-1054 | A global view on the development of non communicable diseases. | For a long time non communicable diseases (NCDs) were discussed as burden of the developed world. Recent alarming data show a reverse trend and a dramatic increase of NCDs in the developing world, in particular in highly populated transition countries. This is true for the main mortality triggering diseases such as CVD... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22178469"
} |
MED-1055 | Why the Bush administration and the global sugar industry are determined to demolish the 2004 WHO global strategy on diet, physical activity and he... | OBJECTIVE: To indicate why the world's most powerful nation state and one powerful sector of the food and drink production and manufacturing industry are determined to demolish the 2004 WHO (World Health Organization) global strategy on diet, physical activity and health, and to disassociate it from the 2003 WHO/FAO (F... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15153268"
} |
MED-1056 | NOW AND THEN: The Global Nutrition Transition: The Pandemic of Obesity in Developing Countries | Decades ago discussion of an impending global pandemic of obesity was thought of as heresy. Diets in the 1970’s began to shift toward increased reliance upon processed foods, increased away from home intake and greater use of edible oils and sugar-sweetened beverages. Reduced physical activity and increased sedentary t... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22221213"
} |
MED-1058 | Political context of the World Health Organization: sugar industry threatens to scupper the WHO. | The Sugar Association, representing the U.S. sugar industry, is highly critical of a WHO report on guidelines for healthy eating, which suggests that sugar should account for no more than 10 percent of a healthy diet. The association has demanded that Congress end its funding of the World Health Organization unless the... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/14758862"
} |
MED-1060 | Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis | Environmental factors such as diets rich in saturated fats contribute to dysfunction and death of pancreatic β-cells in diabetes. Endoplasmic reticulum (ER) stress is elicited in β-cells by saturated fatty acids. Here we show that palmitate-induced β-cell apoptosis is mediated by the intrinsic mitochondrial pathway. By... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22773666"
} |
MED-1061 | Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and ... | BACKGROUND: To determine whether there is an association between diet and plasma insulin concentration that is independent of obesity, we studied the relation of dietary composition and caloric intake to obesity and plasma insulin concentrations in 215 nondiabetic men aged 32-74 years with angiographically proven coron... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/1934376"
} |
MED-1062 | Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. | The prevalence of Type 2 diabetes is increasing dramatically as a result of the obesity epidemic, and poses a major health and socio-economic burden. Type 2 diabetes develops in individuals who fail to compensate for insulin resistance by increasing pancreatic insulin secretion. This insulin deficiency results from pan... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18481955"
} |
MED-1063 | Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | BACKGROUND: The results of some epidemiologic studies conducted by using questionnaires suggest that dietary fat composition influences diabetes risk. Confirmation of this finding with use of a biomarker is warranted. OBJECTIVE: We prospectively investigated the relation of plasma cholesterol ester (CE) and phospholipi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12816776"
} |
MED-1066 | Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. | The relations of dietary habits to insulin sensitivity and postprandial triglyceride metabolism were evaluated in 25 patients with nonalcoholic steatohepatitis (NASH) and 25 age-, body mass index (BMI)-, and gender-matched healthy controls. After a 7-day alimentary record, they underwent a standard oral glucose toleran... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12668986"
} |
MED-1067 | Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. | BACKGROUND AND AIM: Studies have shown monounsaturated oleic acid to be less toxic than palmitic acid and to prevent/attenuate palmitic acid hepatocites toxicity in steatosis models in vitro. However, to what degree these effects are mediated by steatosis extent is unknown. METHODS: We evaluated whether steatosis per s... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19207680"
} |
MED-1068 | Molecular Mechanisms and the Role of Saturated Fatty Acids in the Progression of Non-Alcoholic Fatty Liver Disease | The steady rise in Western obesity rates has been closely linked to significant increases in a multitude of accompanying health problems including Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD severity ranges from simple steatosis to acute steatohepatitis, but the molecular mechanisms controlling progression of this... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23178552"
} |
MED-1069 | Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clear... | AIMS/HYPOTHESIS: Prolonged elevation of plasma specific fatty acids may exert differential effects on glucose-stimulated insulin secretion (GSIS), insulin sensitivity and clearance. SUBJECTS AND METHODS: We examined the effect of oral ingestion, at regular intervals for 24 h, of an emulsion containing either predominan... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16596361"
} |
MED-1070 | The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. | AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estim... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19855953"
} |
MED-1071 | Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. | BACKGROUND: Elevated serum saturated fatty acid levels and hepatocyte lipoapoptosis are features of nonalcoholic fatty liver disease (NAFLD). AIM: The purpose of this study was to investigate saturated fatty acid induction of lipoapoptosis in human liver cells and the underlying mechanisms. METHODS: Human liver L02 and... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24132507"
} |
MED-1072 | Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study. | The purpose of this study was to examine the relationship of body mass index, abdomen-hip ratio, and dietary intake to fasting and postprandial insulin concentrations among 652 men aged 43-85 y, followed in the Normative Aging Study. Log-transformed fasting insulin was significantly associated with body mass index, abd... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/8338037"
} |
MED-1097 | Moses Maimonides: medieval physician and scholar. | Moses Maimonides (1135-1204), physician and philosopher, was the greatest Jewish thinker of the Middle Ages. Faced with a life of persecution, exile, and tragedy, Maimonides overcame obstacles to become the leading physician in his era, a clinician whose skills were sought across continents. Despite long days caring fo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10493314"
} |
MED-1098 | Intake of dioxins and related compounds from food in the U.S. population. | The first U.S. nationwide food sampling with measurement of dioxins, dibenzofurans, and coplanar, mono-ortho and di-ortho polychlorinated biphenyls (PCBs) is reported in this study. Twelve separate analyses were conducted on 110 food samples divided into pooled lots by category. The samples were purchased in 1995 in su... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11346131"
} |
MED-1099 | Evidence of effects of environmental chemicals on the endocrine system in children. | Pollutant chemicals that are widespread in the environment can affect endocrine signaling, as evidenced in laboratory experiments and in wildlife with relatively high exposures. Although humans are commonly exposed to such pollutant chemicals, the exposures are generally low, and clear effects on endocrine function fro... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12837917"
} |
MED-1100 | Lower Serum Testosterone Associated with Elevated Polychlorinated Biphenyl Concentrations in Native American Men | Background Polychlorinated biphenyls (PCBs) and chlorinated pesticides are endocrine disruptors, altering both thyroid and estrogen hormonal systems. Less is known of action on androgenic systems. Objective We studied the relationship between serum concentrations of testosterone in relation to levels of PCBs and three ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19750113"
} |
MED-1101 | Exposure of human fetal penile cells to different PCB mixtures: transcriptome analysis points to diverse modes of interference on external genitali... | The effects exerted by three mixtures of Polychlorinated Biphenyls (PCBs) were evaluated on human fetal corpora cavernosa cells, as a model for male external genitalia development. The three mixtures feature congeners grouped according to potentially shared modes of action: one dioxin-like (DL) (Mix2) and two non dioxi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21334430"
} |
MED-1103 | Dietary Acrylamide Intake and the Risk of Lymphatic Malignancies: The Netherlands Cohort Study on Diet and Cancer | Background Acrylamide, a probable human carcinogen, is present in many everyday foods. Since the finding of its presence in foods in 2002, epidemiological studies have found some suggestive associations between dietary acrylamide exposure and the risk of various cancers. The aim of this prospective study is to investig... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22723843"
} |
MED-1104 | Multiple myeloma : recent progress in diagnosis and treatment. | Multiple myeloma (MM) has been the most intractable hematological disease for many years. Recently, basic and clinical research has advanced remarkably and a new therapeutic strategy has been established. The introduction of high-dose melphalan with autologous stem-cell transplantation and the availability of molecular... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23269074"
} |
MED-1105 | A CASE OF MULTIPLE MYELOMA PRESENTING AS A BULLOUS DERMATOSIS | Multiple myeloma is a malignant plasma cell proliferative disorder that produces a monoclonal immunoglobulin protein. The skin involvement and the development of bullous disease are rarely seen features in multiple myeloma. We present a 55-year-old man with a longstanding, large, tense bullous eruption and hypertrophic... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19881994"
} |
MED-1106 | Cancer in British vegetarians: updated analyses of 4998 incident cancers in a cohort of 32,491 meat eaters, 8612 fish eaters, 18,298 vegetarians, and 2246 vegans | Background: Vegetarian diets might affect the risk of cancer. Objective: The objective was to describe cancer incidence in vegetarians and nonvegetarians in a large sample in the United Kingdom. Design: This was a pooled analysis of 2 prospective studies including 61,647 British men and women comprising 32,491 meat eat... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24898235"
} |
MED-1107 | From myeloma precursor disease to multiple myeloma: new diagnostic concepts and opportunities for early intervention. | Since monoclonal gammopathy of undetermined significance (MGUS) was first described more than 30 years ago, the definition of the entity has evolved. Today, 3 distinct clinical MGUS subtypes have been defined: non-immunoglobulin M (IgM; IgG or IgA) MGUS, IgM MGUS, and light chain MGUS. Each clinical MGUS subtype is cha... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21411440"
} |
MED-1108 | Consumption of artificial sweetener– and sugar-containing soda and risk of lymphoma and leukemia in men and women | Background: Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. Objective: We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. Design: We repeatedly assessed diet in the Nurses’ Health Study... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23097267"
} |
MED-1109 | Risk factors for multiple myeloma: a hospital-based case-control study in Northwest China. | BACKGROUND: The distinctive racial/ethnic and geographic distribution of multiple myeloma (MM) suggests that both family history and environmental factors may contribute to its development. METHODS: A hospital-based case-control study consisting of 220 confirmed MM cases and 220 individually matched patient controls, b... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22673750"
} |
MED-1110 | The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-te... | PURPOSE: To determine the effect of curcumin on plasma cells and osteoclasts in patients with MGUS. EXPERIMENTAL DESIGN: Twenty-six patients with MGUS were recruited into the study and administered 4 grams/day oral curcumin. Blood and urine samples were collected at specified visits after initiating therapy. Full blood... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19737963"
} |
MED-1111 | Clinical Trials and Observations: Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study | Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma-cell proliferative disorder associated with a life-long risk of progression to multiple myeloma (MM). It is not known whether MM is always preceded by a premalignant asymptomatic MGUS stage. Among 77 469 healthy adults enrolled in the na... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19179464"
} |
MED-1112 | Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma... | Because of the central role of the transcription factor nuclear factor-kappaB (NF-kappaB) in cell survival and proliferation in human multiple myeloma (MM), we explored the possibility of using it as a target for MM treatment by using curcumin (diferuloylmethane), an agent known to have very little or no toxicity in hu... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12393461"
} |
MED-1113 | Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled cross-... | Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) represent useful models for studying multiple myeloma precursor disease, and for developing early intervention strategies. Administering a 4g dose of curcumin, we performed a randomised, double-blind placebo-controlled cross... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22473809"
} |
MED-1114 | Occupational exposure to meat and risk of lymphoma: a multicenter case-control study from Europe. | Several studies have suggested an increased risk of lymphoma among workers exposed to meat, without conclusive evidence. We conducted a multicenter case-control study during 1998-2004 in the Czech Republic, France, Germany, Ireland, Italy and Spain, including 2,007 cases of non-Hodgkin lymphoma, 339 cases of Hodgkin ly... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17691115"
} |
MED-1115 | Disparities in the prevalence, pathogenesis and progression of monoclonal gammopathy of undetermined significance and multiple myeloma between blacks and whites | There is marked racial disparity in the incidence of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma, with a two to threefold increased risk in blacks compared with whites. The increased risk has been seen both in Africans and African Americans. Similarly, an increased risk of monoclonal ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22193966"
} |
MED-1116 | Molecular mimicry between HLA-DR alleles associated with rheumatoid arthritis and Proteus mirabilis as the Aetiological basis for autoimmunity. | Molecular mimicry is one of the pathological mechanisms proposed to explain the association between microorganisms and autoimmune diseases. This review deals with the association between bacteria and rheumatic diseases with a special emphasis on rheumatoid arthritis where upper urinary tract infection by Proteus mirabi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11099935"
} |
MED-1118 | Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet. | OBJECTIVE: To measure Proteus mirabilis and Escherichia coli antibody levels in patients with rheumatoid arthritis (RA) during treatment by vegetarian diet. METHODS: Sera were collected from 53 RA patients who took part in a controlled clinical trial of fasting and a one year vegetarian diet. P mirabilis and E coli ant... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/7748020"
} |
MED-1120 | Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease. | Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strepto... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16455580"
} |
MED-1121 | Rheumatoid Arthritis is an Autoimmune Disease Triggered by Proteus Urinary Tract Infection | Rheumatoid arthritis (RA) is a chronic and disabling polyarthritic disease, which affects mainly women in middle and old age. Extensive evidence based on the results of various microbial, immunological and molecular studies from different parts of the world, shows that a strong link exists between Proteus mirabilis mic... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16603443"
} |
MED-1122 | Evidence that patients with rheumatoid arthritis have asymptomatic 'non-significant' Proteus mirabilis bacteriuria more frequently than healthy con... | OBJECTIVES: patients with rheumatoid arthritis (RA) are reported to have in their sera raised levels of antibody specific to Proteus mirabilis. The aim of the study was to verify this and to determine an explanation for it by investigating the frequency of P. mirabilis urinary tract infection in RA patients and matched... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10342649"
} |
MED-1123 | Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis. | OBJECTIVES: To provide a state of the art of economic analyses applied to rheumatoid arthritis (RA). METHODS: A systematic literature review on economic consequences and pharmacoeconomic issues of RA was performed. RESULTS: 127 valid articles were examined in this review. Generally, the financial impact of RA is substa... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23072761"
} |
MED-1124 | An uncooked vegan diet shifts the profile of human fecal microflora: computerized analysis of direct stool sample gas-liquid chromatography profiles of bacterial cellular fatty acids. | The effect of an uncooked extreme vegan diet on fecal microflora was studied by direct stool sample gas-liquid chromatography (GLC) of bacterial cellular fatty acids and by quantitative bacterial culture by using classical microbiological techniques of isolation, identification, and enumeration of different bacterial s... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/1482187"
} |
MED-1125 | Rheumatoid arthritis is caused by a Proteus urinary tract infection. | Genetic, molecular and biological studies indicate that rheumatoid arthritis (RA), a severe arthritic disorder affecting approximately 1% of the population in developed countries, is caused by an upper urinary tract infection by the microbe, Proteus mirabilis. Elevated levels of specific antibodies against Proteus bact... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23992372"
} |
MED-1126 | An update on bioactive plant lignans. | Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6-C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives du... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16311631"
} |
MED-1127 | Rheumatoid arthritis is caused by Proteus: the molecular mimicry theory and Karl Popper. | Rheumatoid arthritis is a crippling and disabling joint disease affecting over 20 million people. It occurs predominantly in women and smokers, and affects the HLA-DR1/4 individuals who carry the "shared epitope" of amino acids EQRRAA. The cause of this disease was investigated by the methods of the philosopher of scie... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19482674"
} |
MED-1128 | Rheumatoid arthritis is linked to Proteus--the evidence. | Rheumatoid arthritis (RA) is a chronic inflammatory arthritic and potentially disabling condition, mainly affecting women of middle age and having characteristic clinical features. Various microbial agents were implicated in the causation of RA. Extensive literature based on the results of various genetic, microbiologi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17206398"
} |
MED-1129 | Rheumatic fever: from sore throat to autoimmune heart lesions. | Molecular mimicry between streptococci and heart components has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). In this review, we present data from cellular autoimmune responses, focusing on the interactions between HLA class II molecules, streptococcal peptides and hea... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15103230"
} |
MED-1130 | Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet. | The beneficial effect of a 1-yr vegetarian diet in RA has recently been demonstrated in a clinical trial. We have analysed stool samples of the 53 RA patients by using direct stool sample gas-liquid chromatography of bacterial cellular fatty acids. Based on repeated clinical assessments disease improvement indices were... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/8019792"
} |
MED-1131 | Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet. | To clarify the role of the faecal flora in the diet-induced decrease of rheumatoid arthritis (RA) activity, 43 RA patients were randomized into two groups: the test group to receive living food, a form of uncooked vegan diet rich in lactobacilli, and the control group to continue their ordinary omnivorous diets. Based ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/9117178"
} |
MED-1133 | Prevalence of Kidney Stones in the United States | Background The last nationally representative assessment of kidney stone prevalence in the United States occurred in 1994. After a 13-yr hiatus, the National Health and Nutrition Examination Survey (NHANES) reinitiated data collection regarding kidney stone history. Objective Describe the current prevalence of stone di... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22498635"
} |
MED-1134 | Effects of low animal protein or high-fiber diets on urine composition in calcium nephrolithiasis. | BACKGROUND: The purpose of this article is to evaluate the impact of low protein and high fiber intakes on risk factors of stone recurrence in idiopathic calcium stone formers (ICSFs). METHODS: Ninety-six ICSFs were randomly assigned a low animal protein diet (< 10% of total energy), a high-fiber diet (> 25 g/day), or ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10720964"
} |
MED-1135 | Should recurrent calcium oxalate stone formers become vegetarians? | The hypothesis that the incidence of calcium stone disease is related to the consumption of animal protein has been examined. Within the male population, recurrent idiopathic stone formers consumed more animal protein than did normal subjects. Single stone formers had animal protein intakes intermediate between those o... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/534817"
} |
MED-1136 | The effect of high animal protein intake on the risk of calcium stone-formation in the urinary tract. | 1. Studies were carried out on six normal male subjects to determine the short-term effect of increasing the dietary consumption of animal protein on the urinary risk factors for stone-formation, namely, volume, pH, calcium oxalate, uric acid and glycosaminoglycans. 2. An increase of 34 g/day of animal protein in the d... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/573189"
} |
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