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MED-1377 | Higher Diet Quality Is Associated with Decreased Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality among Older Adults | Increased attention in dietary research and guidance has been focused on dietary patterns, rather than on single nutrients or food groups, because dietary components are consumed in combination and correlated with one another. However, the collective body of research on the topic has been hampered by the lack of consis... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24572039"
} |
MED-1378 | Longevity and diet. Myth or pragmatism? | Longevity is a very complex phenomenon, because many environmental, behavioral, socio-demographic and dietary factors influence the physiological pathways of aging and life-expectancy. Nutrition has been recognized to have an important impact on overall mortality and morbidity; and its role in extending life expectancy... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24210636"
} |
MED-1380 | Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study | Objective To investigate the relative importance of the individual components of the Mediterranean diet in generating the inverse association of increased adherence to this diet and overall mortality. Design Prospective cohort study. Setting Greek segment of the European Prospective Investigation into Cancer and nutrit... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19549997"
} |
MED-1381 | Nut consumption, vegetarian diets, ischemic heart disease risk, and all-cause mortality: evidence from epidemiologic studies. | Perhaps one of the most unexpected and novel findings in nutritional epidemiology in the past 5 y has been that nut consumption seems to protect against ischemic heart disease (IHD). Frequency and quantity of nut consumption have been documented to be higher in vegetarian than in nonvegetarian populations. Nuts also co... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10479222"
} |
MED-1383 | Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: evidence for a mechanism of antioxidant tuning. | BACKGROUND AND AIMS: The intake of antioxidant-rich foods may increase the blood levels of non enzymatic antioxidant capacity (NEAC). NEAC takes into account all antioxidants from food and synergistic effects between them. We examined the effect of a 1-year intervention with Mediterranean diet on plasma NEAC and assess... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23484910"
} |
MED-1386 | Communicating clinical research to reduce cancer risk through diet: Walnuts as a case example | Inflammation is one mechanism through which cancer is initiated and progresses, and is implicated in the etiology of other conditions that affect cancer risk and prognosis, such as type 2 diabetes, cardiovascular disease, and visceral obesity. Emerging human evidence, primarily epidemiological, suggests that walnuts im... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/25110552"
} |
MED-1387 | Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis. | BACKGROUND: Epidemiologic studies have shown inverse associations between nut consumption and diabetes, cardiovascular disease (CVD), and all-cause mortality, but results have not been consistent. OBJECTIVE: We assessed the relation between nut intake and incidence of type 2 diabetes, CVD, and all-cause mortality. DESI... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24847854"
} |
MED-1388 | Nut consumption and 5-y all-cause mortality in a Mediterranean cohort: the SUN project. | OBJECTIVE: The aim of this study was to assess the association between nut consumption and all-cause mortality after 5-y follow-up in a Spanish cohort. METHODS: The SUN (Seguimiento Universidad de Navarra, University of Navarra Follow-up) project is a prospective cohort study, formed by Spanish university graduates. In... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24976427"
} |
MED-1389 | The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. | BACKGROUND & AIMS: Metabolic syndrome (MetS), in which a non-classic feature is an increase in systemic oxidative biomarkers, presents a high risk of diabetes and cardiovascular disease (CVD). Adherence to the Mediterranean Diet (MedDiet) is associated with a reduced risk of MetS. However, the effect of the MedDiet on ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22999065"
} |
MED-1390 | Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study | Background It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil intake, its varieties (extra virgin and common olive oil) and the risk of cardiovascular disease and mo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24886626"
} |
MED-1393 | Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial. | OBJECTIVE: The Prevención con Dieta Mediterránea (PREDIMED) trial showed that a Mediterranean diet (MedDiet) supplemented with either extra virgin olive oil or 30 g/d of mixed nuts reduced incident cardiovascular events compared with a control (low fat) diet. The mechanisms of cardiovascular protection afforded by MedD... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24285581"
} |
MED-1394 | Primary prevention of cardiovascular disease with a Mediterranean diet. | BACKGROUND: Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events. METHODS: In a multicenter trial in Sp... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23432189"
} |
MED-1395 | Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. | In a prospective, randomised single-blinded secondary prevention trial we compared the effect of a Mediterranean alpha-linolenic acid-rich diet to the usual post-infarct prudent diet. After a first myocardial infarction, patients were randomly assigned to the experimental (n = 302) or control group (n = 303). Patients ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/7911176"
} |
MED-1397 | Omega-3 fatty acids and antioxidants in edible wild plants. | Human beings evolved on a diet that was balanced in the omega-6 and omega-3 polyunsaturated fatty acids (PUFA), and was high in antioxidants. Edible wild plants provide alpha-linolenic acid (ALA) and higher amounts of vitamin E and vitamin C than cultivated plants. In addition to the antioxidant vitamins, edible wild p... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15455656"
} |
MED-1398 | Mediterranean diet and cardiovascular disease: historical perspective and latest evidence. | The concept that the Mediterranean diet was associated with a lower incidence of cardiovascular disease (CVD) was first proposed in the 1950s. Since then, there have been randomized controlled trials and large epidemiological studies that reported associations with lower CVD: in 1994 and 1999, the reports of the interm... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24105622"
} |
MED-1399 | Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Di... | BACKGROUND: The Lyon Diet Heart Study is a randomized secondary prevention trial aimed at testing whether a Mediterranean-type diet may reduce the rate of recurrence after a first myocardial infarction. An intermediate analysis showed a striking protective effect after 27 months of follow-up. This report presents resul... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/9989963"
} |
MED-1400 | Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. | BACKGROUND: The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes. OBJECTIVE: We aimed to update our previous meta-analysis of published cohort prospective studies that investigated the effects of adherence to the Mediterranean diet on health status. ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20810976"
} |
MED-1401 | Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies | The link between iron intake as well as body iron stores and coronary heart disease (CHD) has been contentiously debated, and the epidemiologic evidence is inconsistent. We aimed to quantitatively summarize the literature on the association between dietary iron intake/body iron stores and CHD risk by conducting a meta-... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24401818"
} |
MED-1402 | Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. | OBJECTIVE: To update previous meta-analyses of cohort studies that investigated the association between the Mediterranean diet and health status and to utilize data coming from all of the cohort studies for proposing a literature-based adherence score to the Mediterranean diet. DESIGN: We conducted a comprehensive lite... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24476641"
} |
MED-1403 | Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis | Background Several epidemiological studies have observed an increased risk of type 2 diabetes mellitus (T2DM) among subjects with a higher consumption of red and processed meat. Heme iron intake has been directly associated with a higher risk of T2DM in healthy adult Chinese and U.S populations. The objective of the pr... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24188615"
} |
MED-1404 | The effect of Mediterranean diet on the development of type 2 diabetes mellitus: a meta-analysis of 10 prospective studies and 136,846 participants. | OBJECTIVE: The purpose of this work was to meta-analyze prospective studies that have evaluated the effect of a Mediterranean diet on the development of type 2 diabetes. MATERIALS/METHODS: PubMed, Embase and the Cochrane Central Register of Controlled Trials databases were searched up to 20 November 2013. English langu... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24931280"
} |
MED-1405 | Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial | Background Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationsh... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24886552"
} |
MED-1406 | Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk. | The relation between dietary magnesium intake and cardiovascular disease (CVD) or mortality was evaluated in several prospective studies, but few of them have assessed the risk of all-cause mortality, which has never been evaluated in Mediterranean adults at high cardiovascular risk. The aim of this study was to assess... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24259558"
} |
MED-1407 | The Mediterranean Diet: A History of Health | The Mediterranean tradition offers a cousine rich in colors, aromas and memories, which support the taste and the spirit of those who live in harmony with nature. Everyone is talking about the Mediterranean diet, but few are those who do it properly, thus generating a lot of confusion in the reader. And so for some it ... | {
"url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684452/"
} |
MED-1408 | Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis. | OBJECTIVE: This meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease. METHODS: Potentially eligible publications were those providing effect estimates of relative ris... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23720230"
} |
MED-1409 | Changing prevalence of coronary heart disease risk factors and cardiovascular diseases in men of a rural area of Crete from 1960 to 1991. | This study compares the prevalence of coronary heart disease (CHD), risk factors (RF), and cardiovascular diseases (CVD) among Cretan men from a rural area examined in 1960 and 1991. The study population consisted of 148 men in 1960 and 42 men in 1991 of the same age group (fifty-five to fifty-nine years old) and from ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/8546344"
} |
MED-1410 | The diet and 15-year death rate in the seven countries study. | In 15 cohorts of the Seven Countries Study, comprising 11,579 men aged 40-59 years and "healthy" at entry, 2,288 died in 15 years. Death rates differed among cohorts. Differences in mean age, blood pressure, serum cholesterol, and smoking habits "explained" 46% of variance in death rate from all causes, 80% from corona... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/3776973"
} |
MED-1411 | The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. | OBJECTIVES: The aim of this study was to meta-analyze epidemiological studies and clinical trials that have assessed the effect of a Mediterranean diet on metabolic syndrome (MS) as well as its components. BACKGROUND: The Mediterranean diet has long been associated with low cardiovascular disease risk in adult populati... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21392646"
} |
MED-1412 | Faecal pH value and its modification by dietary means in South African black and white schoolchildren. | Mean faecal pH values did not differ significantly in groups of rural South African Black schoolchildren of 10--12 years who ate their traditional high-fibre low-fat diet, and urban dwellers who consumed a partially westernized diet. However, both means were significantly lower than those of groups of White schoolchild... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/36672"
} |
MED-1413 | Human gut microbiota: does diet matter? | The human oro-gastrointestinal (GI) tract is a complex system, consisting of oral cavity, pharynx, oesophagus, stomach, small intestine, large intestine, rectum and anus, which all together with the accessory digestive organs constitute the digestive system. The function of the digestive system is to break down dietary... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/25156389"
} |
MED-1414 | High colonic pH promotes colorectal cancer. | Considerable evidence suggests that the carcinogens or co-carcinogens responsible for the development of colorectal cancer are either bacterially degraded bile acids or cholesterol. It is proposed that a high colonic pH promotes co-carcinogen formation from these substances and that acidification of the colon either by... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/6112450"
} |
MED-1415 | A vegan or vegetarian diet substantially alters the human colonic faecal microbiota. | BACKGROUND/OBJECTIVES: Consisting of ≈10(14) microbial cells, the intestinal microbiota represents the largest and the most complex microbial community inhabiting the human body. However, the influence of regular diets on the microbiota is widely unknown. SUBJECTS/METHODS: We examined faecal samples of vegetarians (n=1... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21811294"
} |
MED-1416 | Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology. | Mean faecal urobilinogen levels and the pH of stools were both found to be higher in subjects from a population group at high risk of developing cancer of the colon than in subjects matched for age, sex and socioeconomic status from a low-risk population group. An alkaline reaction of the colon contents seems to have a... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/7120255"
} |
MED-1417 | Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans | Background: Epidemiologic studies have suggested that most cases of sporadic colon cancer can be attributed to diet. The recognition that colonic microbiota have a major influence on colonic health suggests that they might mediate colonic carcinogenesis. Objective: To examine the hypothesis that the influence of diet o... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23719549"
} |
MED-1418 | Hydrogen sulfide induces direct radical-associated DNA damage. | Hydrogen sulfide (H(2)S) is produced by indigenous sulfate-reducing bacteria in the large intestine and represents an environmental insult to the colonic epithelium. Clinical studies have linked the presence of either sulfate-reducing bacteria or H(2)S in the colon with chronic disorders such as ulcerative colitis and ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17475672"
} |
MED-1419 | A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of 'faecal water'. | To determine the effects of different diets on the genotoxicity of human faecal water, a diet rich in fat, meat and sugar but poor in vegetables and free of wholemeal products (diet 1) was consumed by seven healthy volunteers over a period of 12 days. One week after the end of this period, the volunteers started to con... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10590225"
} |
MED-1420 | Nutrition and colonic health: the critical role of the microbiota. | PURPOSE OF REVIEW: To highlight mechanisms whereby diet affects colonic function and disease patterns. RECENT FINDINGS: Topical nutrients are preferentially used by the gut mucosa to maintain structure and function. With the colon, topical nutrients are generated by the colonic microbiota to maintain mucosal health. Mo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18043233"
} |
MED-1421 | Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humans. | BACKGROUND: Hydrogen sulfide is a luminally acting, bacterially derived cell poison that has been implicated in ulcerative colitis. Sulfide generation in the colon is probably driven by dietary components such as sulfur-containing amino acids (SAAs) and inorganic sulfur (eg, sulfite). OBJECTIVE: We assessed the contrib... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11101476"
} |
MED-1425 | Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the inc... | We examined the correlation between the incidence of Crohn disease and dietary change in a relatively homogeneous Japanese population. The incidence and daily intake of each dietary component were compared annually from 1966 to 1985. The univariate analysis showed that the increased incidence of Crohn disease was stron... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/8615358"
} |
MED-1426 | Influence of dietary protein supplements on the formation of bacterial metabolites in the colon. | BACKGROUND: To evaluate the influence of increased dietary protein intake on bacterial colonic metabolism in healthy volunteers. METHODS: Short chain fatty acids, ammonia, and volatile organic compounds in faecal samples, and phenols in the urine of five volunteers were measured after one week of basal nutrient intake ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/9274475"
} |
MED-1428 | Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. | The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are min... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15172426"
} |
MED-1429 | Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the s... | The first four reviews in this series (Steinberg, D. 2004. J. Lipid Res. 45: 1583-1593; Steinberg, D. 2005. J. Lipid Res. 46: 179-190; Steinberg, D. 2005. J. Lipid Res. 46: 2037-2051; Steinberg, D. 2006. J. Lipid Res. 47: 1-14) traced the gradual accumulation of evidence, evidence of several different kinds, supporting... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16585781"
} |
MED-1430 | Vegetarian diet and cholesterol and triglycerides levels. | OBJECTIVE: Compare levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) among vegetarians and omnivores. METHODS: Blood samples were collected from 76 individuals--both males and females--separated in four different diet groups: omnivores, lacto-ovo veget... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17364116"
} |
MED-1431 | Advanced glycation end product level, diabetes, and accelerated cognitive aging | Objective: Several studies report that diabetes increases risk of cognitive impairment; some have hypothesized that advanced glycation end products (AGEs) underlie this association. AGEs are cross-linked products that result from reactions between glucose and proteins. Little is known about the association between peri... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21900628"
} |
MED-1432 | Do Sirtuins Promote Mammalian Longevity?: A Critical Review on Its Relevance to the Longevity Effect Induced by Calorie Restriction | Sirtuins (SIRTs), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, are emerging as key molecules that regulate aging and age-related diseases including cancers, metabolic disorders, and neurodegenerative diseases. Seven isoforms of SIRT (SIRT1–7) have been identified in mammals. SIRT1 and 6, ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23661364"
} |
MED-1433 | Dietary Advanced Glycation End Products and Aging | Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older a... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22254007"
} |
MED-1434 | Protective effects and mechanisms of sirtuins in the nervous system | Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone deacetylases whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). They suppress genome-wide transcription, yet upregulate a select set of proteins related to energy metabolism and pro-survival me... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21930182"
} |
MED-1435 | Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. | Age-related loss of brain tissue has been inferred from cross-sectional neuroimaging studies, but direct measurements of gray and white matter changes from longitudinal studies are lacking. We quantified longitudinal magnetic resonance imaging (MRI) scans of 92 nondemented older adults (age 59-85 years at baseline) in ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12716936"
} |
MED-1436 | Sirtuins in cognitive ageing and Alzheimer's disease. | PURPOSE OF REVIEW: Sirtuins are a family of enzymes highly conserved in evolution and involved in mechanisms known to promote healthy ageing and longevity. This review aims to discuss recent advances in understanding the role of sirtuins, in particular mammalian SIRT1, in promoting longevity and its potential molecular... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22327552"
} |
MED-1437 | At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. | Longevity, lifespan, cancer, cellular transformation, energy, calorie restriction, diabetes--what can tie together such a diversity of hot topics in biomedical research? Emerging findings suggest that the answer lies in understanding the functions of the recently discovered family of proteins known as Sirtuins. Barcelo... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20458180"
} |
MED-1438 | Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals | Background Advanced glycations end products increase oxidant stress, inflammation, and neurotoxicity. Serum levels are increased in diabetes and aging. We examined the relationship between serum methylglyoxal derivatives (sMG), and cognitive decline, in 267 non-demented elderly. Methods Tobit mixed regression models as... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22079406"
} |
MED-1439 | Brain volume changes on longitudinal magnetic resonance imaging in normal older people. | BACKGROUND AND PURPOSE: The purpose of this study is to investigate the longitudinal age-related changes in human brain volume using stereological methods. METHODS: Sixty-six older participants (34 men, 32 women, age [mean +/- SD] 78.9 +/- 3.3 years, range 74-87 years) with normal baseline and follow-up examinations un... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11677879"
} |
MED-1440 | SIRT1 Decrease Parallels the Accumulation of tau in Alzheimer Disease | Aging and metabolism-related disorders are risk factors for Alzheimer disease (AD). Since sirtuins may increase the lifespan through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hyb... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/19104446"
} |
MED-1441 | The Science of Salsa: Antimicrobial Properties of Salsa Components to Learn Scientific Methodology | Most ethnic foods and cooking practices have incorporated the use of spices and other food additives. Many common spices have crossed cultural boundaries and appear in multiple ethnic cuisines. Recent studies have demonstrated that many of these ingredients possess antimicrobial properties against common food spoilage ... | {
"url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577155/"
} |
MED-1442 | Genetic Analysis of Chemosensory Traits in Human Twins | We explored genetic influences on the perception of taste and smell stimuli. Adult twins rated the chemosensory aspects of water, sucrose, sodium chloride, citric acid, ethanol, quinine hydrochloride, phenylthiocarbamide (PTC), potassium chloride, calcium chloride, cinnamon, androstenone, Galaxolide™, cilantro, and bas... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22977065"
} |
MED-1443 | Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. | SUMMARY BACKGROUND: Coriander oil is used as an antimicrobial agent and as a natural fragrance. The present study investigated the anti-inflammatory potency of coriander oil in the ultraviolet (UV) erythema test in vivo. METHODS: 40 volunteers were enrolled in this monocentric,randomized,placebo-controlled double-blind... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18371049"
} |
MED-1444 | Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals--a review. | Coriander (Coriandrum sativum L.), a herbal plant, belonging to the family Apiceae, is valued for its culinary and medicinal uses. All parts of this herb are in use as flavoring agent and/or as traditional remedies for the treatment of different disorders in the folk medicine systems of different civilizations. The pla... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23281145"
} |
MED-1445 | The effects of a low-fat, plant-based dietary intervention on body weight, metabolism, and insulin sensitivity. | PURPOSE: This study investigated the effect of a low-fat, plant-based diet on body weight, metabolism, and insulin sensitivity, while controlling for exercise in free-living individuals. SUBJECTS AND METHODS: In an outpatient setting, 64 overweight, postmenopausal women were randomly assigned to a low-fat, vegan diet o... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/16164885"
} |
MED-1446 | Longitudinal association between animal and vegetable protein intake and obesity among adult males in the United States: the Chicago Western Electric Study | Literature on the association of protein intake with body weight is inconsistent. Little is known about the relation of long-term protein intake to obesity. This study aimed to determine the association between protein intake and obesity. A cohort of 1,730 employed white men ages 40–55 years from the Chicago Western El... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21802560"
} |
MED-1447 | Nutrient intake in the GEICO multicenter trial: the effects of a multicomponent worksite intervention | Background/objectives: To assess the effects on macro- and micronutrient intake of a nutrition intervention program in corporate settings across the United States. Subjects/methods: Two hundred and ninety-two individuals who were overweight or had type 2 diabetes were recruited from 10 sites of a US insurance company. ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23942177"
} |
MED-1448 | The costs of obesity in the workplace. | OBJECTIVE: To quantify per capita and aggregate medical expenditures and the value of lost productivity, including absenteeism and presenteeism, because of overweight, and grade I, II, and III obesity among U.S. employees. METHODS: Cross-sectional analysis of the 2006 Medical Expenditure Panel Survey and the 2008 Natio... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20881629"
} |
MED-1449 | Workplace wellness programs can generate savings. | Amid soaring health spending, there is growing interest in workplace disease prevention and wellness programs to improve health and lower costs. In a critical meta-analysis of the literature on costs and savings associated with such programs, we found that medical costs fall by about $3.27 for every dollar spent on wel... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20075081"
} |
MED-1450 | A multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study | Background/objectives: To determine the effects of a low-fat plant-based diet program on anthropometric and biochemical measures in a multicenter corporate setting. Subjects/methods: Employees from 10 sites of a major US company with body mass index ⩾25 kg/m2 and/or previous diagnosis of type 2 diabetes were randomized... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23695207"
} |
MED-1451 | The link between workforce health and safety and the health of the bottom line: tracking market performance of companies that nurture a "culture of... | OBJECTIVE: To test the hypothesis that comprehensive efforts to reduce a workforce's health and safety risks can be associated with a company's stock market performance. METHODS: Stock market performance of Corporate Health Achievement Award winners was tracked under four different scenarios using simulation and past m... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24013656"
} |
MED-1454 | Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. | AIMS/HYPOTHESIS: The amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. METHODS: The KANWU study included 162 healthy subjects cho... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11317662"
} |
MED-1455 | Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids | The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. The focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxici... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23509418"
} |
MED-1456 | Veganism and its relationship with insulin resistance and intramyocellular lipid. | OBJECTIVE: To test the hypothesis that dietary factors in the vegan diet lead to improved insulin sensitivity and lower intramyocellular lipid (IMCL) storage. DESIGN: Case-control study. SETTING: Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK. SUBJECTS: A total of 24 vegans and 25 omnivore... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15523486"
} |
MED-1457 | A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. | Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and reduced mitochondrial mass and function. We hypothesized a HFD may affect expression of genes involved in mitochondrial function and biogenesis. To test this hypothesis, we fed 10 insulin-sensitive males an isoenergetic HFD for 3 days with ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15983191"
} |
MED-1458 | Higher insulin sensitivity in vegans is not associated with higher mitochondrial density. | BACKGROUND/OBJECTIVES: Vegans have a lower incidence of insulin resistance (IR)-associated diseases and a higher insulin sensitivity (IS) compared with omnivores. The aim of this study was to examine whether the higher IS in vegans relates to markers of mitochondrial biogenesis and to intramyocellular lipid (IMCL) cont... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24149445"
} |
MED-1459 | Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links | Insulin resistance is a complex metabolic disorder that defies a single etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded protein response (UPR) pathway and innate immune pathways have all been implicated in the pathogenesis of insulin resistance. However, these pathways are als... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22385956"
} |
MED-1460 | Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function | Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking insulin resistance to these syndromes are not precisely defined yet, evidence suggests that the elevated plasma free fatty acid (FFA) level p... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/22360800"
} |
MED-1461 | Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy as... | Insulin resistance is the best prediction factor for the clinical onset of type 2 diabetes. It was suggested that intramuscular triglyceride store may be a primary pathogenic factor for its development. To test this hypothesis, 14 young lean offspring of type 2 diabetic parents, a model of in vivo insulin resistance wi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10426379"
} |
MED-1463 | Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. | Insulin resistance is a pathophysiological link of obesity to type 2 diabetes. The initial cause of insulin resistance is critical for prevention and treatment of type 2 diabetes. Lipotoxicity is a well-known concept in the explanation of initiation of insulin resistance. Although there are several prevailing hypothese... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17346204"
} |
MED-1464 | Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. | OBJECTIVE: To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: A case-cohort design was used to randomly select 580 incident cases of diabetes and 566 noncases from 10,275 African-American and white men and women in th... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/14693970"
} |
MED-1465 | Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. | An increased intramyocellular lipid (IMCL) content, as quantified by (1)H-magnetic resonance spectroscopy ((1)H-MRS), is associated with reduced insulin sensitivity. At present, it is unclear which factors determine IMCL formation and how rapidly IMCL accumulation can be induced. We therefore studied the impact of hype... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11679437"
} |
MED-1466 | How free fatty acids inhibit glucose utilization in human skeletal muscle. | Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose fro... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/15143200"
} |
MED-1467 | Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots. | Human adiposity has long been associated with insulin resistance and increased cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra-abdominal fat is associated with insulin resistance, possibly mediated by greater lipolytic activity, lower adiponectin levels, resistance to leptin, and ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23550081"
} |
MED-1468 | Dynamics of fat cell turnover in humans. | Obesity is increasing in an epidemic manner in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes. Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in rec... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18454136"
} |
MED-1470 | Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. | Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid (approximately 45 min) determi... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10027589"
} |
MED-1471 | Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. | Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as with insulin resistance and hyperinsulinemia, two important cardiovascular risk factors. What causes insulin resistance and hyperinsulinemia in obesity remains uncertain. Here, we have tested the hypothesis that FFAs are the li... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/0010480616"
} |
MED-1472 | Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. | The initial effects of free fatty acids (FFAs) on glucose transport/phosphorylation were studied in seven healthy men in the presence of elevated (1.44 +/- 0.16 mmol/l), basal (0.35 +/- 0.06 mmol/l), and low (<0.01 mmol/l; control) plasma FFA concentrations (P < 0.05 between all groups) during euglycemic-hyperinsulinem... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10334314"
} |
MED-1473 | Mechanism of free fatty acid-induced insulin resistance in humans. | To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P nuclear magnetic resonance spectroscopy in nine healthy subjects in the presence of low (0.18 +/- 0.02 mM [mean +/- SEM]; co... | {
"url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507380/"
} |
MED-1474 | Free fatty acids and skeletal muscle insulin resistance. | PURPOSE OF REVIEW: Acute exposure to fatty acids causes insulin resistance in muscle, and excess dietary lipid and obesity are also strongly associated with muscle insulin resistance. Relevant mechanisms, however, are still not fully elucidated. Here we examine the latest evidence as to why lipids might accumulate in m... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/18460913"
} |
MED-1475 | Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents | Objective To explain the predisposition for insulin resistance among African American (AA) adolescents, this study aimed to: 1) examine changes in intramyocellular lipid content (IMCL), and insulin sensitivity with intralipid (IL) infusion; and 2) determine whether the increase in IMCL is comparable between AA and Cauc... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23122836"
} |
MED-1476 | Neanderthal cannibalism at Moula-Guercy, Ardèche, France. | The cave site of Moula-Guercy, 80 meters above the modern Rhone River, was occupied by Neanderthals approximately 100,000 years ago. Excavations since 1991 have yielded rich paleontological, paleobotanical, and archaeological assemblages, including parts of six Neanderthals. The Neanderthals are contemporary with stone... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/10506562"
} |
MED-1478 | Paleolithic nutrition: twenty-five years later. | A quarter century has passed since the first publication of the evolutionary discordance hypothesis, according to which departures from the nutrition and activity patterns of our hunter-gatherer ancestors have contributed greatly and in specifically definable ways to the endemic chronic diseases of modern civilization.... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/21139123"
} |
MED-1479 | BEYOND THE PALEOLITHIC PRESCRIPTION: INCORPORATING DIVERSITY AND FLEXIBILITY IN THE STUDY OF HUMAN DIET EVOLUTION | Evolutionary paradigms of human health and nutrition center on the evolutionary discordance or “mismatch” model whereby human bodies, reflecting adaptations established in the Paleolithic era, are ill-suited to modern industrialized diets resulting in rapidly increasing rates of chronic metabolic disease. Whereas this ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23865796"
} |
MED-1482 | Does hand hygiene compliance among health care workers change when patients are in contact precaution rooms in ICUs? | BACKGROUND: Hand hygiene compliance rates among health care workers (HCW) rarely exceed 50%. Contact precautions are thought to increase HCWs' hand hygiene awareness. We sought to determine any differences in hand hygiene compliance rates for HCW between patients in contact precaution and those not in any isolation. ME... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20189682"
} |
MED-1483 | Empirical evaluation of very large treatment effects of medical interventions. | CONTEXT: Most medical interventions have modest effects, but occasionally some clinical trials may find very large effects for benefits or harms. OBJECTIVE: To evaluate the frequency and features of very large effects in medicine. DATA SOURCES: Cochrane Database of Systematic Reviews (CDSR, 2010, issue 7). STUDY SELECT... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23093165"
} |
MED-1484 | Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002 | SYNOPSIS Objective The purpose of this study was to provide a national estimate of the number of healthcare-associated infections (HAI) and deaths in United States hospitals. Methods No single source of nationally representative data on HAIs is currently available. The authors used a multi-step approach and three data ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17357358"
} |
MED-1486 | Patient expectations on lipid-lowering drugs. | OBJECTIVE: The objective of this study was to assess expectations of effect when using statins in a treatment population. Further the aim was to examine factors, including history and concurrent risk of coronary heart disease, associated with a higher and lower treatment belief. METHODS: Eight hundred and twenty-nine (... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/17433602"
} |
MED-1487 | Patients' Expectations of Screening and Preventive Treatments | PURPOSE An informed decision to accept a health care intervention requires an understanding of its likely benefit. This study assessed participants' estimates of the benefit, as well as minimum acceptable benefit, of screening for breast and bowel cancer and medication to prevent hip fracture and cardiovascular disease... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23149525"
} |
MED-1488 | What benefit do patients expect from adding second and third antihypertensive drugs? | Aims To discover whether patients have the same expectations of benefit from taking the first and any additional drugs for the treatment of hypertension and to investigate any patient characteristics which predict willingness to take treatment. Methods This was an anonymous questionnaire survey carried out in a single ... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/11849200"
} |
MED-1489 | A way to reverse CAD? | PURPOSE: Plant-based nutrition achieved coronary artery disease (CAD) arrest and reversal in a small study. However, there was skepticism that this approach could succeed in a larger group of patients. The purpose of our follow-up study was to define the degree of adherence and outcomes of 198 consecutive patient volun... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/25198208"
} |
MED-1490 | Are preventive drugs preventive enough? A study of patients' expectation of benefit from preventive drugs. | OBJECTIVES: The study aimed to find the threshold of benefit for a hypothetical cholesterol-lowering drug below which the subject would not be prepared to take the drug. We also looked at whether proximity to the target event (myocardial infarction) and the subjects' views on drug taking affected this threshold. DESIGN... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/12528966"
} |
MED-1491 | Flaxseed fed pork: n-3 fatty acid enrichment and contribution to dietary recommendations. | The potential to increase n-3 fatty acid (FA) intake via flaxseed fed pork is underestimated when restricted to pure longissimus muscle, whereas a combination of muscle and adipose tissue is typically consumed. Presently, the FA content of pigs fed 0%, 5% and 10% dietary flaxseed for 11 weeks was measured in loin, picn... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24012977"
} |
MED-1492 | The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline bloo... | BACKGROUND: The benefits of reducing blood pressure are well established, but there remains uncertainty about whether the magnitude of the effect varies with the initial blood pressure level. The objective was to compare the risk reductions achieved by different blood pressure-lowering regimens among individuals with d... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/20881867"
} |
MED-1493 | Flaxseed - a miraculous defense against some critical maladies. | Presence of omega-3, omega-6 rich oil, alpha-linoleic acid, dietary fibers, secoisolariciresinol diglucoside, protein and minerals in flaxseed constitute a very strong basis for the utilization of flaxseed in various food preparations as a curative agent. An extensive body of literature illustrates that flaxseed has ga... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/23261749"
} |
MED-1494 | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | Flaxseed contains ω-3 fatty acids, lignans, and fiber that together may provide benefits to patients with cardiovascular disease. Animal work identified that patients with peripheral artery disease may particularly benefit from dietary supplementation with flaxseed. Hypertension is commonly associated with peripheral a... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24126178"
} |
MED-1495 | Response surface methodology for predicting quality characteristics of beef patties added with flaxseed and tomato paste. | Response surface methodology was used to study the effect of flaxseed flour (FS) and tomato paste (TP) addition, from 0 to 10% and 0 to 20% respectively, on beef patty quality characteristics. The assessed quality characteristics were color (L, a, and b), pH and texture profile analysis (TPA). Also, sensory analysis wa... | {
"url": "http://www.ncbi.nlm.nih.gov/pubmed/24509360"
} |
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