text stringlengths 3 799 |
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" C |
2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits the denaturation of proteins. |
Option B: It inhibits cell-wall biosynthesis. |
Option C: It selectively inhibits mitosis and cell division. |
Option D: It inhibits DNA synthesis. |
" A |
5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has a rapid onset of action and short half-life. |
Option B: It works quickly and has a short half-life. |
Option C: It has a fast onset of action. |
Option D: It displays rapid absorption and onset of action with the shortest half-life and duration of action. |
" B |
6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C=CC(=O)N |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. |
Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. |
Option C: It may or may not have direct interaction with DNA for cancer induction. |
Option D: It has direct actions on blood vessels and increases cardiac output. |
" C |
5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It closes N-type voltage-operated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. |
Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels. |
Option C: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). |
Option D: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers. |
" A |
115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits acetylcholinesterase. |
Option B: It inhibits cholinesterase enzyme. |
Option C: It binds irreversibly to acetylcholinesterase. |
Option D: It cannot be broken down by acetylcholinesterase and the binding is irreversible. |
" D |
104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It stimulates activation of new platelets and increases platelet aggregation. |
Option B: Its effectiveness is enhanced when administered in combination with cilastatin. |
Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. |
" B |
3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. |
Option B: It competitively blocks adrenergic stimulation of β-receptors and α1-receptors. |
Option C: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. |
Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. |
" B |
6099959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mg+2].[Mg+2].[Mg+2] |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has a fast onset of action. |
Option B: It works primarily through the high osmolarity of the solution. |
Option C: It has a slow onset of action and exhibits a ""ceiling effect"". |
Option D: It has a rapid onset of action and short half-life. |
" B |
68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. |
Option B: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. |
Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. |
Option D: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. |
" C |
991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits acetylcholinesterase. |
Option B: It inhibits cholinesterase enzyme. |
Option C: It acts as an inhibitor of cholinesterase. |
Option D: It acts by inhibition of cholinesterase activity. |
" C |
36811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. |
Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. |
Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. |
" C |
4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has systemic protective, curative, and eradicant action. |
Option B: It has curative, protective, and eradicant action. |
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration. |
Option D: It is a noncompetitive NMDA receptor antagonist. |
" D |
45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
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