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Option A: It inhibits DNA synthesis. |
Option B: It acts as a defective substrate for NS5B. |
Option C: It inhibits bacterial protein synthesis. |
Option D: It interferes with bacterial protein synthesis. |
" B |
4096 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: COP(=O)(N)SC |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits cholinesterase enzyme. |
Option B: It inhibits acetylcholinesterase. |
Option C: It acts by inhibition of cholinesterase activity. |
Option D: It binds irreversibly to acetylcholinesterase. |
" B |
4506 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3 |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It acts as a selective agonist for the retinoic acid receptors (RAR). |
Option B: It acts as an agonist to the GABA receptors. |
Option C: It enhances the binding of GABA to GABAA receptors. |
Option D: It does not interact with GABA receptors. |
" C |
2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
Option B: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. |
Option C: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels. |
Option D: It inhibits gastric acid secretion, pepsin, and gastrins output. |
" D |
2942 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CN(C)N=NC1=C(NC=N1)C(=O)N |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It interacts with 14-alpha demethylase. |
Option B: It interacts with 14-α demethylase. |
Option C: It inhibits DNA synthesis and interacts with SH groups. |
Option D: It causes premature chain termination during translation taking place in the ribosome. |
" C |
7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1(=NC(=NC(=N1)N)N)N |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It causes kidney malfunction. |
Option B: It has direct actions on blood vessels and increases cardiac output. |
Option C: It causes relaxation of smooth muscle in blood vessels and the prostate. |
Option D: It may cause liver failure. |
" A |
3346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits cholinesterase enzyme. |
Option B: It acts by inhibition of cholinesterase activity. |
Option C: It binds irreversibly to acetylcholinesterase. |
Option D: It inhibits acetylcholinesterase. |
" A |
5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. |
Option B: It has direct actions on blood vessels and increases cardiac output. |
Option C: It acts within three to five minutes. |
Option D: It causes relaxation of smooth muscle in blood vessels and the prostate. |
" C |
135398744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. |
Option B: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. |
Option C: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises. |
Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. |
" C |
10607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It is very irritating to skin and mucous membranes and has keratolytic actions. |
Option B: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. |
Option C: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. |
Option D: It induces a variety of defects including those affecting morphology and egg laying. |
" A |
43226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)(C3=CN=CN=C3)O)Cl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits bacterial protein synthesis. |
Option B: It inhibits the fungus's biosynthesis of important steroid molecules. |
Option C: It inhibits microbial cellular protein synthesis. |
Option D: It interferes with bacterial protein synthesis. |
" B |
5280961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It works primarily through the high osmolarity of the solution. |
Option B: It has a slow onset of action and exhibits a ""ceiling effect"". |
Option C: It directly stimulates the plasma membrane-associated adenylate cyclases. |
Option D: It has a fast onset of action. |
" C |
774 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1=C(NC=N1)CCN |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. |
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. |
Option C: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. |
Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. |
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