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Option A: It can inhibit phosphodiesterases and may have direct actions on calcium channels. |
Option B: It has direct actions on blood vessels and increases cardiac output. |
Option C: It exhibits the action of binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function. |
Option D: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. |
" C |
5282181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. |
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. |
Option C: It exhibits the action of having prolonged pharmacological actions compared to vitamin D due to a negative feedback mechanism regulating the final activation step of vitamin D in the kidneys. |
Option D: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. |
" C |
6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It exhibits the action of interfering with photosynthesis by entering the plant through the root zone and moving throughout the plant. |
Option B: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. |
Option C: It exhibits the action of interfering with mitotic division through contact. |
Option D: It undergoes biotransformation to form the active moiety for antifungal actions. |
" C |
3676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has a fast onset of action. |
Option B: It has slower onsets and longer durations of action. |
Option C: Its effects are more intense and its duration of action is shorter. |
Option D: It has a slow onset of action and exhibits a ""ceiling effect"". |
" C |
5504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1CN=C(N1)CC2=CC=CC=C2 |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It causes relaxation of smooth muscle in blood vessels and the prostate. |
Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. |
Option C: It has direct actions on blood vessels and increases cardiac output. |
Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. |
" C |
3690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has a slow onset of action and exhibits a ""ceiling effect"". |
Option B: It has a fast onset of action. |
Option C: It primarily acts through the alkylation of DNA. |
Option D: It works primarily through the high osmolarity of the solution. |
" C |
8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It inhibits cell-wall biosynthesis. |
Option B: It inhibits normal cell division of microorganisms. |
Option C: It has a direct cytotoxic effect on microorganisms and cancer cells. |
Option D: It selectively inhibits mitosis and cell division. |
" B |
702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CCO |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It does not interact with GABA receptors. |
Option B: It enhances the binding of GABA to GABAA receptors. |
Option C: It acts as an agonist to the GABA receptors. |
Option D: It acts as a selective agonist for the retinoic acid receptors (RAR). |
" C |
25419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It selectively inhibits mitosis and cell division. |
Option B: It affects mineralized tissues, especially bone. |
Option C: It inhibits cell-wall biosynthesis. |
Option D: It suppresses inflammation and stimulates cell-mediated immunity. |
" B |
2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. |
Option B: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. |
Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. |
Option D: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. |
" D |
5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It has an antagonist action on the 5-HT3 receptors. |
Option B: It first acts on the mu-opioid receptors. |
Option C: It interacts predominantly with the opioid mu-receptors. |
Option D: It does not interact with GABA receptors. |
" B |
5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It suppresses inflammation and stimulates cell-mediated immunity. |
Option B: It inhibits cell-wall biosynthesis. |
Option C: It selectively inhibits mitosis and cell division. |
Option D: It inhibits DNA synthesis. |
" C |
444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. |
Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C |
Question about this molecule: Which kind of action does this molecule have/exhibit? |
Option A: It appears to block dopamine uptake. |
Option B: It can increase and sustain plasma levodopa concentrations. |
Option C: It has direct actions on blood vessels and increases cardiac output. |
Option D: It has dopaminergic effects. |
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