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2,335,700 | Lymphocyte sparing normal tissue effects in the clinic (LymphoTEC): A systematic review of dose constraint considerations to mitigate radiation-related lymphopenia in the era of immunotherapy. | Radiation-related lymphopenia has been associated with suboptimal tumor control rates leading to inferior survival outcomes. To date, no standardized dose constraints are available to limit radiation dose to resident and circulating lymphocyte populations. We undertook this systemic review of the literature to provide ... |
2,335,701 | Mixture 2D Convolutions for 3D Medical Image Segmentation. | Three-dimensional (3D) medical image segmentation plays a crucial role in medical care applications. Although various two-dimensional (2D) and 3D neural network models have been applied to 3D medical image segmentation and achieved impressive results, a trade-off remains between efficiency and accuracy. To address this... |
2,335,702 | Biophysical characterization of the first ultra-cyclist in the world to break the 1,000 km barrier in 24-h non-stop road cycling: A case report. | A plethora of factors determine elite cycling performance. Those include training characteristics, pacing strategy, aerodynamics, nutritional habits, psychological traits, physical fitness level, body mass composition, and contextual features; even the slightest changes in any of these factors can be associated with pe... |
2,335,703 | Application of Preoperative Adductor Canal Block Coupled with General Anaesthesia in Elderly Patients Undergoing Total Knee Arthroplasty. | To investigate the clinical application of preoperative adductor canal block combined with general anaesthesia in elderly patients with total knee arthroplasty.</AbstractText>Seventy-four patients scheduled for elective TKA in Shaanxi Nuclear Industry Hospital No. 215 were selected and were assigned into group A (conti... |
2,335,704 | Effects of Combined Spinal Epidural Anesthesia in Orthopaedic Surgery of Elderly Patients. | Combined spinal epidural anesthesia (CSEA) is applied to lower limb orthopaedic surgery in the elderly. This study is aimed at exploring the effect of CSEA in orthopaedic surgery of elderly patients.</AbstractText>A total of 40 elderly patients with femoral fracture needing hip replacement or femoral head replacement i... |
2,335,705 | Novel use of erector spinae plane block in laparoscopic surgery. | Thoracic epidural and paravertebral blocks are gold standard analgesic techniques but they are associated with complications. Erector spinae plane (ESP) block is safer with comparable pain relief. ESP block is an established technique for postoperative pain relief. Its intraoperative use as an adjuvant to general anaes... |
2,335,706 | Assessment of the changes in cardiac sympathetic nervous activity using the pupil size changes measured in seated patients whose stellate ganglion is blocked by interscalene brachial plexus block. | As a side effect of interscalene brachial plexus block (ISBPB), stellate ganglion block (SGB) causes reductions in pupil size (Horner's syndrome) and cardiac sympathetic nervous activity (CSNA). Reduced CSNA is associated with hemodynamic instability when patients are seated. Therefore, instantaneous measurements of CS... |
2,335,707 | Catheter Ablation for Paroxysmal Atrial Fibrillation With Sick Sinus Syndrome: Insights From the Kansai Plus Atrial Fibrillation Registry.<Pagination><StartPage>205</StartPage><EndPage>214</EndPage><MedlinePgn>205-214</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.hlc.2022.09.007</ELocationID... | Coexisting sick sinus syndrome (SSS) is associated with both electrical and structural atrial remodelling in patients with atrial fibrillation (AF). Limited data are available concerning catheter ablation (CA) for AF in this condition. This study investigated the efficacy of CA as a curative therapy for AF and SSS in a... |
2,335,708 | Exosomes as Potential Functional Nanomaterials for Tissue Engineering. | Exosomes are cell-derived extracellular vesicles of 40-160 nm diameter, which carry numerous biomolecules and transmit information between cells. They are used as functional nanomaterials with great potential in biomedical areas, such as active agents and delivery systems for advanced drug delivery and disease the... |
2,335,709 | Ventricular arrhythmias in Kearns-Sayre syndrome: A cohort study using the National Inpatient Sample database 2016-2019.<Pagination><StartPage>1357</StartPage><EndPage>1363</EndPage><MedlinePgn>1357-1363</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/pace.14607</ELocationID><Abstract><AbstractT... | Degeneration of the cardiac conduction system resulting in complete heart block (CHB), ventricular arrhythmias (VA), and sudden cardiac death (SCD) is recognized in patients with Kearns-Sayre syndrome (KSS) and is potentially preventable with permanent pacemaker (PPM) implantation. However, other mechanisms for SCD hav... |
2,335,710 | Replacement of dietary corn with corn bran plus condensed distillers solubles effects on feedlot growth performance and carcass trait responses of beef steers. | Dry-corn milling biorefineries have the opportunity to install technology to fractionate corn prior to fermentation, which creates a product stream of fibrous bran that can be fed to cattle. The objective of this study was to determine the effects of replacing dietary corn with corn bran and condensed distillers solubl... |
2,335,711 | Role of Strauss ECG criteria as predictor of response in patients undergoing cardiac resynchronization therapy.<Pagination><StartPage>69</StartPage><MedlinePgn>69</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">69</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s43044-022-00308-3</ELocationI... | <i>Objectives.</i> Detection of sensitive signs in many work environments with automated systems (aviation industry, flight safety tower, maritime industry, monitoring in the military industry, etc.) is essential and requires constant visual attention. Therefore, the aim of this study was to investigate the effect of f... |
2,335,712 | Effect of caudally administered clonidine on sevoflurane induced emergence agitation-A randomized trial. | Emergence agitation (EA) is an unpleasant problem encountered in children following anesthesia with Sevoflurane. We studied the effectiveness of caudal epidural block (CEB) with ropivacaine 0.2% and clonidine two microgram per kilogram (mcg/kg) on the incidence of EA, with respiratory depression and hemodynamic variabl... |
2,335,713 | Cardiopulmonary and muscular effects of different doses of high-intensity physical training in substance use disorder patients: study protocol for a block allocated controlled endurance and strength training trial in an inpatient setting. | Patients with substance use disorder (SUD) have high prevalence of lifestyle-related comorbidities. Physical exercise is known to yield substantial prophylactic impact on disease and premature mortality, and there seems to be an inverse association between physical fitness and adverse health outcomes. High-intensity tr... |
2,335,714 | Effects of sequential aeromedical evacuations following traumatic brain injury in swine. | Traumatic brain injuries (TBI) represent a significant percentage of critical injuries in military conflicts. Following injury, wounded warfighters are often subjected to multiple aeromedical evacuations (AE) and associated hypobaria, yet the impact in TBI patients remains to be characterized. This study evaluated the ... |
2,335,715 | Aspirin Cessation Before Interventional Procedures: Not Blindly Following Guidelines but Making Test-based Decisions. | Deciding whether to continue or discontinue aspirin prior to interventional procedures is a major concern for pain physicians. Many guidelines have been published on the discontinuation of aspirin before invasive procedures; however, the recommendations are inconsistent and do not consider individual platelet function.... |
2,335,716 | Integrated fan cooling of the lower back for wheelchair users. | A large proportion of a wheelchair user's body is in contact with their wheelchair. Integrated fan cooling systems fitted to a wheelchair's backrest aim to alleviate the build-up of heat at the skin-chair interface. The aim of this pilot study was to evaluate the effectiveness of an integrated fan cooling system at coo... |
2,335,717 | Cardiac Manifestations of Lyme Disease.<Pagination><StartPage>553</StartPage><EndPage>561</EndPage><MedlinePgn>553-561</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.idc.2022.03.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0891-5520(22)00031-9</ELocationID><Abstract><AbstractText>... | Lyme carditis is an uncommon manifestation of Lyme disease. Most cases present with heart block of varying degrees, but the spectrum of disease includes other transient arrhythmias and structural manifestations, such as myopericarditis or cardiomyopathy. Antibiotics hasten the resolution of Lyme carditis, and cardiac p... |
2,335,718 | Permanent Left Bundle Branch Area Pacing for High-Degree Atrioventricular Block in a 6-Year-Old Child with 2-Year Follow-Up.<Pagination><StartPage>957</StartPage><EndPage>962</EndPage><MedlinePgn>957-962</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1536/ihj.22-103</ELocationID><Abstract><AbstractT... | The feasibility and safety of left bundle branch area pacing (LBBAP) used in pediatric patients with atrioventricular block (AVB) have not been well demonstrated. Currently, only several case reports for pediatric patients have been published since the advent of LBBAP, with 3 months to 1 year follow-up. Here, we presen... |
2,335,719 | Emergencies in obstetric anaesthesia: a narrative review.<Pagination><StartPage>1416</StartPage><EndPage>1429</EndPage><MedlinePgn>1416-1429</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/anae.15839</ELocationID><Abstract><AbstractText>We conducted a narrative review in six areas of obstetric e... | We conducted a narrative review in six areas of obstetric emergencies: category-1 caesarean section; difficult and failed airway; massive obstetric haemorrhage; hypertensive crisis; emergencies related to neuraxial anaesthesia; and maternal cardiac arrest. These areas represent significant research published within the... |
2,335,720 | Transversus Abdominis Plane Block Reduces Intraoperative Opioid Consumption in Patients Undergoing Periacetabular Osteotomy. | Administering intraoperative analgesia in patients undergoing periacetabular osteotomy (PAO) is challenging due to both the relevant surgical approach and osteotomies, which are associated with pain. The aim of this study was to assess the effect of the transversus abdominis plane block (TAPb) on intraoperative opioid ... |
2,335,721 | Plasmatic catecholamines after neuraxial labour analgesia: A randomised controlled trial comparing epidural versus combined spinal-epidural. | Combined spinal-epidural technique (CSE) for labour analgesia has been associated with fetal bradycardia and uterine hypertonia when compared with epidural analgesia (EA), possibly due to a decrease in epinephrine levels following neuraxial anaesthesia. However, there are no recent studies comparing plasmatic catechola... |
2,335,722 | Automatic localization of target point for subthalamic nucleus-deep brain stimulation via hierarchical attention-UNet based MRI segmentation. | Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for patients with advanced Parkinson's disease, the outcome of this surgery is highly dependent on the accurate placement of the electrode in the optimal target of STN.</AbstractText>In this study, we aim to develop a target localizat... |
2,335,723 | Paragastric Autonomic Neural Blockade to Prevent Early Visceral Pain and Associated Symptoms After Laparoscopic Sleeve Gastrectomy: a Randomized Clinical Trial. | Visceral pain (VP) following laparoscopic sleeve gastrectomy remains a substantial problem. VP is associated with autonomic symptoms, especially nausea and vomiting, and is unresponsive to traditional pain management algorithms aimed at alleviating somatic (incisional) pain. The present study was performed to evaluate ... |
2,335,724 | Six- to eight-year-olds' performance in the Heart and Flower task: Emerging proactive cognitive control. | The Heart and Flower task is used worldwide to measure age-dependent and individual differences in executive functions and/or cognitive control. The task reliably maps age and individual differences and these have consistently been found to be predictive for different aspects of school readiness and academic achievemen... |
2,335,725 | Optimal Dose of Dexmedetomidine for Preemptive Analgesia Combined with Transversus Abdominis Plane Block after Colon Cancer Surgery. | Pain after colon cancer surgery can be effectively relieved by transversus abdominis plane (TAP) block. We aimed to determine the optimal dose of dexmedetomidine for preemptive analgesia when combined with TAP block after colon cancer surgery.</AbstractText>A total of 120 patients undergoing laparoscopic resection for ... |
2,335,726 | A Prospective Randomized Study Comparing the Bolus Doses of Norepinephrine and Phenylephrine for the Treatment of Spinal Induced Hypotension in Cesarean Section. | Spinal anesthetic-induced hypotension is the most worrisome complication for patients undergoing cesarean section under spinal anesthesia. The present study compares norepinephrine and phenylephrine bolus for the treatment of hypotension during spinal anesthesia for cesarean section.</AbstractText>One hundred twenty- s... |
2,335,727 | Right lung transplantation with a left-to-right inverted anastomosis in a rat model.<Pagination><StartPage>429</StartPage><EndPage>439</EndPage><MedlinePgn>429-439</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.xjon.2022.01.020</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategor... | Right lung transplantation in rats has been attempted occasionally, but the technical complexity makes it challenging to apply routinely. Additionally, basic research on inverted lobar lung transplantation is scarce because of the lack of a cost-effective experimental model. We first reported right lung transplantation... |
2,335,728 | Analgesic Effects of a Novel Combination of Regional Anesthesia After Pediatric Cardiac Surgery: A Retrospective Cohort Study.<Pagination><StartPage>4054</StartPage><EndPage>4061</EndPage><MedlinePgn>4054-4061</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1053/j.jvca.2022.07.014</ELocationID><ELoca... | Since pharmaceutical treatment options are lacking in the clinical management of abdominal aortic aneurysm (AAA), animal models, in particular mouse models, are applied to advance the understanding of the disease pathogenesis and to identify potential therapeutic targets. Testing novel drug candidates to block AAA grow... |
2,335,729 | Addition of 2 mg dexamethasone to improve the anesthetic efficacy of 2% lidocaine with 1:80,000 epinephrine administered for inferior alveolar nerve block to patients with symptomatic irreversible pulpitis in the mandibular molars: a randomized double-blind clinical trial. | This clinical trial aimed to evaluate the anesthetic effect of the addition of 2 mg (4 mg/ml) of dexamethasone to 2% lidocaine (plain or with 1:80,000 epinephrine). The solutions were injected for a primary inferior alveolar nerve block (IANB) to provide mandibular anesthesia for the endodontic treatment of mandibular ... |
2,335,730 | Retrospective analysis of remifentanil combined with dexmedetomidine intravenous anesthesia combined with brachial plexus block on shoulder arthroscopic surgery in elderly patients. | To analyze the effect of remifentanil combined with dexmedetomidine intravenous anesthesia combined with brachial plexus block on shoulder arthroscopic surgery in elderly patients.</AbstractText>This retrospective study conducted at Jiading Branch of Shanghai General Hospital, investigated clinical data from elderly pa... |
2,335,731 | Detection of Cardiac Functions of Fetus with Diabetic Metabolic Disease through PEG-PCLNano Micelle and Ultrasound Technique.<Pagination><StartPage>24</StartPage><EndPage>33</EndPage><MedlinePgn>24-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.14715/cmb/2022.68.3.4</ELocationID><Abstract><Abstra... | Pacemakers are electronic devices that stimulate the heart with electrical impulses to maintain or restore a normal heartbeat. In 1952, Zoll described an effective means of supporting the patients with intrinsic cardiac pacemaker activity and/or conducting tissue by an artificial, electric, external pacemaker. The paci... |
2,335,732 | Global Transformer and Dual Local Attention Network via Deep-Shallow Hierarchical Feature Fusion for Retinal Vessel Segmentation. | Clinically, retinal vessel segmentation is a significant step in the diagnosis of fundus diseases. However, recent methods generally neglect the difference of semantic information between deep and shallow features, which fail to capture the global and local characterizations in fundus images simultaneously, resulting i... |
2,335,733 | Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia. | Glibenclamide (GLB) reduces brain edema and improves neurological outcome in animal experiments and preliminary clinical studies. Recent studies also suggested a strong anti-inflammatory effect of GLB, via inhibiting nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome ... |
2,335,734 | Transcatheter closure of secundum atrial septal defect using Cocoon septal occluder: immediate and long-term results.<Pagination><StartPage>59</StartPage><MedlinePgn>59</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">59</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s43044-022-00298-2</ELoc... | Atrial septal defect (ASD) is one of the common congenital heart defects. Its management has transformed dramatically in the last 4 decades with the transition from surgical to percutaneous transcatheter closure for most secundum-type ASDs. Various devices are available for transcatheter closure of ASD with Amplatzer a... |
2,335,735 | Graph-based homogenisation for modelling cardiac fibrosis. | Fibrosis, the excess of extracellular matrix, can affect, and even block, propagation of action potential in cardiac tissue. This can result in deleterious effects on heart function, but the nature and severity of these effects depend strongly on the localisation of fibrosis and its by-products in cardiac tissue, such ... |
2,335,736 | Pro-Apoptotic and Pro-Autophagic Properties of Cardenolides from Aerial Parts of Pergularia tomentosa. | <i>Pergularia tomentosa</i> L., a milkweed tropical plant belonging to the family Asclepiadaceae, is a rich source of unusual cardiac glycosides, characterised by transfused A/B rings and a sugar moiety linked by a double link, generating a dioxanoid structure. In the present report, five cardenolides isolated from the... |
2,335,737 | Peripheral Nerve and Plexus Blocks for Hip Surgery in a Nonagenarian with Severe Cardiac Disease. | The hemodynamic alterations and stress response associated with anesthesia and surgery are often poorly tolerated by elderly patients. Regional anesthesia techniques are useful in the elderly as they provide excellent perioperative analgesia with minimal hemodynamic perturbations. We report the case of a 90-year-old ma... |
2,335,738 | Acute kidney injury following multisystem inflammatory syndrome associated with SARS-CoV-2 infection in children: a systematic review and meta-analysis. | Multisystem inflammatory syndrome (MIS-C) is a rare paediatric hyper-inflammatory disorder that occurs following SARS-CoV-2 infection. Acute kidney injury (AKI) occurs in approximately one-quarter to one-third of the patients with MIS-C and is associated with poor prognosis in critically ill children. This systematic r... |
2,335,739 | Late Giant Aortic Root Aneurysm Following Aortic Valve Replacement.<Pagination><StartPage>59</StartPage><EndPage>61</EndPage><MedlinePgn>59-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.14797/mdcvj.1118</ELocationID><Abstract><AbstractText>A 74-year-old female with previous permanent pacemaker i... | A 74-year-old female with previous permanent pacemaker insertion for complete heart block and no history of connective tissue disease presented to our regional cardiothoracic center with progressive exertional shortness of breath. Nine years later, when the patient was 83 years old, a computed tomography scan of the th... |
2,335,740 | A curious case of pulmonary hypertension in a child. | Pulmonary hypertension in young children can be due to a myriad of conditions. Few aetiologies of pulmonary hypertension are potentially reversible. An extensive workup for the cause of pulmonary hypertension is a must before attributing it to idiopathic pulmonary hypertension. We describe an uncommon aetiology of pulm... |
2,335,741 | Analgesic effect of ultrasound-guided erector spinae plane block (espb) in general anesthesia for cesarean section: a randomized controlled trial. | The analgesic effects of erector spinae plane block in general anesthesia for cesarean section and recovery from puerperae remain unclear.</AbstractText>Sixty patients with contraindications for spinal anesthesia who required general anesthesia for cesarean section were enrolled and randomly divided into the erector sp... |
2,335,742 | Bilateral Cardiac Sympathetic Denervation for Treatment-Resistant Ventricular Arrhythmias in Heart Failure Patients with a Reduced Ejection Fraction.<Pagination><StartPage>692</StartPage><EndPage>699</EndPage><MedlinePgn>692-699</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1536/ihj.21-601</ELocati... | The sympathetic nervous system plays an important role in life-threatening ventricular arrhythmias (VAs). Bilateral cardiac sympathetic denervation (BCSD) is performed for refractory VAs. We sought to assess our institutional experience with BCSD in managing treatment-resistant monomorphic ventricular tachycardia (MMVT... |
2,335,743 | Atrial myxoma surgery and P-wave remodeling.<Pagination><StartPage>1160</StartPage><EndPage>1164</EndPage><MedlinePgn>1160-1164</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/pace.14573</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Data regarding atrial electrocardiographic paramete... | Data regarding atrial electrocardiographic parameters in patients with atrial myxomas are scarce.</AbstractText>We aimed to study atrial electrocardiographic features in patients with atrial myxomas, before and after surgery. We also analyze the incidence of atrial fibrillation during follow-up and its correlation with... |
2,335,744 | Internal organ and skeletal muscle development in commercial broilers with woody breast myopathy. | Increasing growth rate, body weight, and breast muscle yield have been linked to broiler muscle problems such as woody breast (WB). The aim of this study was to investigate the internal organ and skeletal muscle development of broilers with WB myopathy under dietary and Eimeria challenge treatments. A 3 diet (control, ... |
2,335,745 | PEG-Free Polyion Complex Nanocarriers for Brain-Derived Neurotrophic Factor. | Many therapeutic formulations incorporate poly(ethylene glycol) (PEG) as a stealth component to minimize early clearance. However, PEG is immunogenic and susceptible to accelerated clearance after multiple administrations. Here, we present two novel reformulations of a polyion complex (PIC), originally composed of poly... |
2,335,746 | Electrical Dyssynchrony in Cardiac Amyloidosis: Prevalence, Predictors, Clinical Correlates, and Outcomes.<Pagination><StartPage>1664</StartPage><EndPage>1672</EndPage><MedlinePgn>1664-1672</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cardfail.2022.07.046</ELocationID><ELocationID EIdType="... | A cardiogenic shock patient with a history of a surgical mitral valve replacement presented to the hospital with critical mitral stenosis with thickening of prosthetic valve leaflets and thrombus in left atrial appendage. We considered TMVR inside of the degenerated bioprosthetic valve. However, there were two concerns... |
2,335,747 | Impact of membranous septum length on pacemaker need with different transcatheter aortic valve replacement systems: The INTERSECT registry.<Pagination><StartPage>524</StartPage><EndPage>530</EndPage><MedlinePgn>524-530</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcct.2022.07.003</ELocation... | The term atrioventricular (AV) dissociation describes a family of arrhythmias where independent pacemakers control the atria and ventricles. The standard activation of the cardiac circuits works in the order of impulse transmission from the sinoatrial (SA) node to the atria, the AV node, and ventricular activation... |
2,335,748 | A Cost-Utility Analysis of the Syncope: Pacing or Recording in The Later Years (SPRITELY) Trial. | The S</b>yncope: P</b>acing or R</b>ecording i</b>n t</b>he L</b>ater Y</b>ears (SPRITELY) trial reported that a strategy of empiric permanent pacing in patients with syncope and bifascicular block reduces major adverse events more effectively than acting on the results of an implantable cardiac monitor (ICM). Our obje... |
2,335,749 | Interatrial Block Predicts Life-Threatening Arrhythmias in Dilated Cardiomyopathy.<Pagination><StartPage>e025473</StartPage><MedlinePgn>e025473</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e025473</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.121.025473</ELocationID><Abstract><Abst... | Background Interatrial block (IAB) has been associated with supraventricular arrhythmias and stroke, and even with sudden cardiac death in the general population. Whether IAB is associated with life-threatening arrhythmias (LTA) and sudden cardiac death in dilated cardiomyopathy (DCM) remains unknown. This study aimed ... |
2,335,750 | Associations Between Asthma Diagnosis/Asthma Exacerbation and Previous Proton-Pump Inhibitor use: A Nested Case-Control Study Using a National Health Screening Cohort. | <b>Background:</b> Proton-pump inhibitors (PPIs) block acid secretion from gastric parietal cells; however, recent studies have reported that PPIs have antioxidant and anti-inflammatory properties in various cells. Newer PPIs are stronger inhibitors of acid secretion; however, the anti-inflammatory effects of these dru... |
2,335,751 | <i>In-vivo</i> Sino-Atrial Node Mapping in Children and Adults With Congenital Heart Disease.<Pagination><StartPage>896825</StartPage><MedlinePgn>896825</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">896825</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3389/fped.2022.896825</ELocationID><Abstr... | Kearns-Sayre syndrome (KSS) is a clinical subtype of chronic progressive external ophthalmoplegia (CPEO). KSS is defined by the following triad: onset before the age of 20, CPEO, and pigmentary retinopathy. Affected individuals have at least 1 of the following conditions: complete heart block, cerebrospinal fluid (CSF)... |
2,335,752 | Vitamin B<sub>12</sub> and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.<Pagination><StartPage>1246</StartPage><EndPage>1255</EndPage><MedlinePgn>1246-1255</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2022.06.033</ELocationID><ELocation... | <AbstractText Label="BACKGROUND & AIMS">Several recent clinical studies have shown that serum homocysteine (Hcy) levels are positively correlated, while vitamin B12</sub> (B12</sub>) and folate levels are negative correlated, with non-alcoholic steatohepatitis (NASH) severity. However, it is not known whether hyper... |
2,335,753 | Effects of Different Doses of Dexmedetomidine Combined with Thoracic Paravertebral Nerve Block Anesthesia on Agitation and Hemodynamics in Patients Undergoing Thoracotomy during Recovery. | To investigate the effect of different doses of dexmedetomidine combined with thoracic paravertebral nerve block anesthesia on agitation and hemodynamics in patients undergoing thoracotomy during recovery.</AbstractText>One hundred patients who underwent thoracotomy in our hospital from August 2018 to April 2021 were e... |
2,335,754 | Effect of Preoperative Thoracic Paravertebral Blocks on Emergence Agitation During Tracheal Extubation: A Randomized Controlled Trial. | This study aims to compare the effects of preoperative thoracic paravertebral blocks (TPVB) with intercoastal nerve blocks (ICNB) on emergence agitation (EA) during tracheal extubation in patients who underwent thoracoscopic lobectomy.</AbstractText>A randomized clinical trial was conducted in patients undergoing thora... |
2,335,755 | How to be a better scientist: Lessons from scientific philosophy, the historical development of science, and past errors within exercise physiology. | What is science? While a simple question, the answer is complex. Science is a process involving human behaviour, and due to the human influence, science is often not pursued correctly. In fact, one can argue that we still do not know what the "correct" pursuit of science should entail. This is because science remains a... |
2,335,756 | Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation. | Acute myocardial dysfunction in patients with sepsis is attributed to oxidative stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are still lacking. Tetrahydrocurcumin (THC) has been proven to contribute to the prevention of various cardiovascular diseases by decreasing oxidative ... |
2,335,757 | COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. | The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive... |
2,335,758 | In vivo peripheral nerve activation using sinusoidal low-frequency alternating currents. | The sinusoidal low-frequency alternating current (LFAC) waveform was explored recently as a novel means to evoke nerve conduction block. In the present work, we explored whether increasing the amplitude of the LFAC waveform results in nerve fiber activation in autonomic nerves. In-silico methods and preliminary work in... |
2,335,759 | Intelligent Algorithm-Based Ultrasound for Evaluating the Anesthesia and Nursing Intervention for Elderly Patients with Femoral Intertrochanteric Fractures. | This study was aimed to explore the anesthesia, analgesia, and nursing intervention scheme for elderly patients undergoing the operation of intertrochanteric fracture of femur under the guidance of ultrasound optimized by blind deblurring algorithm. Fifty elderly patients undergoing intertrochanteric femoral surgery we... |
2,335,760 | Short and long-term outcomes of children with autoimmune congenital heart block treated with a combined maternal-neonatal therapy. A comparison study.<Pagination><StartPage>1161</StartPage><EndPage>1168</EndPage><MedlinePgn>1161-1168</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41372-022-014... | The short and long-term outcomes of children with anti-Ro/La-related congenital heart block treated with a combined maternal-neonatal therapy protocol were compared with those of controls treated with other therapies.</AbstractText>Sixteen mothers were treated during pregnancy with a therapy consisting of daily oral fl... |
2,335,761 | Programmed-release intraosseus anesthesia as an alternative to lower alveolar nerve block in lower third molar extraction: a randomized clinical trial. | Intraosseous anesthesia is the process by which an anesthetic solution, after penetration of the cortical bone, is directly injected into the spongiosa of the alveolar bone supporting the tooth. This study aimed to compare the effectiveness of the traditional inferior alveolar nerve block (IANB) and computerized intrao... |
2,335,762 | [Clinical case of the cardiovascular system involvement in a patient with Charcot-Marie-Tooth disease].<Pagination><StartPage>67</StartPage><EndPage>71</EndPage><MedlinePgn>67-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18087/cardio.2022.5.n1810</ELocationID><Abstract><AbstractText>Hereditary ... | Hereditary motor and sensory type 1A neuropathy (known as Charcot-Marie-Tooth disease) is a disease of peripheral nerves characterized by symptoms of progressive polyneuropathy with preferential damage of distal extremity muscles. Damage to the cardiovascular system is extremely rare and heterogenous in this pathology.... |
2,335,763 | The Hemodynamic Parameters Values Prediction on the Non-Invasive Hydrocuff Technology Basis with a Neural Network Applying. | The task to develop a mechanism for predicting the hemodynamic parameters values based on non-invasive hydrocuff technology of a pulse wave signal fixation is described in this study. The advantages and disadvantages of existing methods of recording the ripple curve are noted in the published materials. This study prop... |
2,335,764 | Physiologic Pacing Targeting the His Bundle and Left Bundle Branch: a Review of the Literature.<Pagination><StartPage>959</StartPage><EndPage>978</EndPage><MedlinePgn>959-978</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11886-022-01723-3</ELocationID><Abstract><AbstractText Label="PURPOSE OF... | His-bundle pacing has demonstrated feasibility in numerous adult studies to reverse and prevent pacing-induced cardiomyopathy, however, is met with higher capture thresholds with deployment sheaths designed for adults with his-bundles in the typical location. To describe 24 pediatric and adult congenital patients post-... |
2,335,765 | Efficacy of Dexmedetomidine Anesthesia plus Dorsal Penile Nerve Block in Pediatric Circumcision. | To assess the efficacy of dexmedetomidine anesthesia plus dorsal penile nerve block in pediatric circumcision.</AbstractText>In this retrospective study, 80 children receiving circumcision in our hospital from February 2020 to February 2021 were recruited and assigned via different anesthesia methods at a ratio of 1&#x... |
2,335,766 | Dexmedetomidine prolongs the duration of local anesthetics when used as an adjuvant through both perineural and systemic mechanisms: a prospective randomized double-blinded trial. | To study the respective peripheral and systemic mechanisms of action of dexmedetomidine, as adjuvant to regional anesthesia, we compared dexmedetomidine added to ropivacaine for mid-forearm nerve blocks, to either systemic-only dexmedetomidine, and to a control with no dexmedetomidine.</AbstractText>Sixty patients unde... |
2,335,767 | Clinical effect of ultrasound-guided nerve block and dexmedetomidine anesthesia on lower extremity operative fracture reduction. | Lower extremity fractures are mainly treated by surgical reduction, but this operation is often affected by the patient's level of agitation and the type of anesthesia used. The main treatment for lower-extremity fractures is operative reduction. However, operations can often be affected by both agitation and the degre... |
2,335,768 | "Orphan" Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy. | Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry of calcium into the cells, leading to an arrhythmogenic/cardiomyopath... |
2,335,769 | <i>Pax3</i> Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation <i>in Utero</i>. | Pax3 and Pax7 transcription factors are paralogs within the <i>Pax</i> gene family that that are expressed in early embryos in partially overlapping expression domains and have distinct functions. Significantly, mammalian development is largely unaffected by <i>Pax7</i> systemic deletion but systemic <i>Pax3</i> deleti... |
2,335,770 | Comparison of Temperature and Pain Changes between the Drip and Topical Methods of Administering the Transnasal Sphenopalatine Ganglion Block. | The objective of this study was to compare facial temperatures and the visual analogue scale (VAS) between the drip method and the topical method of transnasal sphenopalatine ganglion block (SPGB). The transnasal SPGB is administered to patients with facial or head and neck pain. In the transnasal approach, the drip an... |
2,335,771 | Ultrasound-guided lumbar medial branch blocks and intra-articular facet joint injections: a systematic review and meta-analysis. | There is great interest in expanding the use of ultrasound (US), but new challenges exist with its application to lumbar facet-targeted procedures. The primary aim of this systematic review and meta-analysis was to determine the risk of incorrect needle placement associated with US-guided lumbar medial branch blocks (M... |
2,335,772 | Effect of Ultrasound-Guided Fascia Iliac Compartment Block on Serum NLRP3 and Inflammatory Factors in Patients with Femoral Intertrochanteric Fracture. | To investigate the effects of ultrasound-guided fascia iliac compartment block (FICB) on patients' postoperative pain and inflammatory factors as well as nucleotide-binding domain and leucine-rich repeat (NLR) family, pyrin domain-containing 3 (NLRP3) in femoral intertrochanteric fracture.</AbstractText>This single-bli... |
2,335,773 | Computer-controlled Intraligamentary local anaesthesia in extraction of mandibular primary molars: randomised controlled clinical trial. | Local anesthesia (LA) poses a threat in children more than the treatment process itself, so pediatric dentists are always demanding less painful techniques. Computer-controlled Intraligamentary anaesthesia (CC-ILA) is designed to reduce injection pain and side effects of conventional techniques. The present study aims ... |
2,335,774 | Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-<i>β</i> Signalling Activation to Ameliorate Myocardial Fibrosis. | Myocardial fibrosis is the main morphological change of ventricular remodelling caused by cardiovascular diseases, mainly manifested due to the excessive production of collagen proteins. SRY-related high mobility group-box gene 9 (SOX9) is a new target regulating myocardial fibrosis. Bellidifolin (BEL), the active comp... |
2,335,775 | GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone. | In the heart, aldosterone (Aldo) binds the mineralocorticoid receptor (MR) to exert damaging, adverse remodeling-promoting effects. We recently showed that G protein-coupled receptor-kinase (GRK)-5 blocks the cardiac MR by directly phosphorylating it, thereby repressing its transcriptional activity. MR antagonist (MRA)... |
2,335,776 | Sugammadex reversal of muscle relaxant blockade provided less Post-Anesthesia Care Unit adverse effects than neostigmine/glycopyrrolate. | Sugammadex is a direct reversal agent of aminosteroid muscle relaxants, particularly rocuronium, with promptly and completely reverse of deep neuromuscular block (NMB), which allows better surgical conditions. Sugammadex exhibits advantages over indirect reversal agent acetylcholinesterase inhibitor neostigmine with le... |
2,335,777 | Cardiopulmonary Effects and Pharmacokinetics of Dexmedetomidine Used as an Adjunctive Analgesic to Regional Anesthesia of the Oral Cavity with Levobupivacaine in Dogs. | This study investigated the cardiopulmonary effects and pharmacokinetics of dexmedetomidine (DEX) used as an adjunctive analgesic for regional anesthesia of the oral cavity with levobupivacaine in anesthetized dogs. Forty dogs were randomly assigned to four groups of 10 dogs. All dogs received levobupivacaine (4 blocks... |
2,335,778 | Abiotic factors and aging alter the physicochemical characteristics and toxicity of Phosphorus nanomaterials to zebrafish embryos. | Nanoscale phosphorus (P)-based formulations are being investigated as potentially new fertilizers to overcome the challenges of conventional bulk P fertilizers in agriculture, including low efficacy rates and high application levels. After agricultural applications, the NMs may be released into aquatic environments and... |
2,335,779 | Femoral and sciatic nerve blockade of the pelvic limb with and without obturator nerve block for tibial plateau levelling osteotomy surgery in dogs. | To determine the effect of blocking the obturator nerve in addition to performing femoral nerve and sciatic nerve blocks on intraoperative nociception in dogs undergoing unilateral tibial plateau levelling osteotomy (TPLO) surgery.</AbstractText>Prospective, blinded, randomized, placebo-controlled, clinical comparison.... |
2,335,780 | The ultrasound-guided funicular block in cats undergoing orchiectomy: ropivacaine injection into the spermatic cord to improve intra and postoperative analgesia. | The orchiectomy in cats is a common surgical procedure with medium level of pain and for this reason requires intra and postoperative analgesia management. The aim of this study was to compare intra and postoperative pain in two groups of cats undergoing orchiectomy. Sixty healthy cats were randomly assigned in two gro... |
2,335,781 | The Salzburg 10/7 HIIT shock cycle study: the effects of a 7-day high-intensity interval training shock microcycle with or without additional low-intensity training on endurance performance, well-being, stress and recovery in endurance trained athletes-study protocol of a randomized controlled trial. | Performing multiple high-intensity interval training (HIIT) sessions in a compressed period of time (approximately 7-14 days) is called a HIIT shock microcycle (SM) and promises a rapid increase in endurance performance. However, the efficacy of HIIT-SM, as well as knowledge about optimal training volumes during a... |
2,335,782 | Thai Patients' Drug Safety Knowledge and Perceptions Relating to Different Forms of Written Medicine Information: A Comparative Study. | The aim of the study was to evaluate the medication safety knowledge, quality of the written medicine information (WMI), and perceptions of taking the medicines in patients receiving package inserts (PIs) in comparison with patient information leaflets (PILs).</AbstractText>A cross-sectional, comparative study was cond... |
2,335,783 | Autophagy is Involved in Cardiac Remodeling in Response to Environmental Temperature Change. | <b>Objectives:</b> To study the reversibility of cold-induced cardiac hypertrophy and the role of autophagy in this process. <b>Background:</b> Chronic exposure to cold is known to cause cardiac hypertrophy independent of blood pressure elevation. The reversibility of this process and the molecular mechanisms involved ... |
2,335,784 | Kearns-Sayre Syndrome Minus: Two Cases of Identical Large-Scale Mitochondrial DNA Deletions with Presentations outside the Classical Triad. | A curious triad of retinitis pigmentosa, external ophthalmoplegia, and complete heart block was presented by Sayre et al. in 1958. Since then, the disorder named Kearns-Sayre syndrome (KSS) has come to represent patients with mitochondrial DNA deletions presenting before adulthood, primarily with chronic progressive ex... |
2,335,785 | Health Outcomes of 215 Mothers of Children With Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry. | Transplacental passage of maternal anti-SSA and anti-SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB).</AbstractText>Th... |
2,335,786 | An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trial. | There are few evidence-based interventions for long COVID; however, holistic approaches supporting recovery are advocated. We assessed whether an online breathing and wellbeing programme improves health related quality-of-life (HRQoL) in people with persisting breathlessness following COVID-19.</AbstractText>We conduct... |
2,335,787 | Association of Socioeconomic Status and Infarct Volume With Functional Outcome in Patients With Ischemic Stroke. | Long-term disability after stroke is associated with socioeconomic status (SES). However, the reasons for such disparities in outcomes remain unclear.</AbstractText>To assess whether lower SES is associated with larger admission infarct volume and whether initial infarct volume accounts for the association between SES ... |
2,335,788 | Pregnancy outcomes of a joint obstetric and rheumatology clinic in a tertiary centre: a 2-year retrospective study of 98 pregnancies. | The purpose of this study was to describe the maternal and fetal outcomes in patients with inflammatory rheumatic diseases attending a joint rheumatology and obstetric clinic in the UK.</AbstractText>Electronic records of 98 patients attending the joint rheumatology and obstetric clinic between January 2018 and January... |
2,335,789 | Comparative Study of Lipid- and Polymer-Supported Membranes Obtained by Vesicle Fusion. | We compare the fusion of giant lipid and block-copolymer vesicles on glass and poly(dimethylsiloxane) substrates. Both types of vesicles are similar in their ability to fuse to hydrophilic substrates and form patches with distinct heart or circular shapes. We use epifluorescence/confocal microscopy and atomic force mic... |
2,335,790 | Effects of the Femoral Nerve Block and Adductor Canal Block on Tourniquet Response and Postoperative Analgesia in Total Knee Arthroplasty. | Tourniquet has emerged as an important role in surgical procedures, sixty patients undergoing elective total knee arthroplasty are randomly divided into the nerve block group and adductor duct block group in this paper. The changes of mean arterial pressure (MAP) and heart rate (HR) at different time points during oper... |
2,335,791 | A Novel Study of Correlation of Lipid Parameters with Clinical Profile, Staging and Onset of Rhino Orbito Cerebral Mucormycosis Covid 19 Pandemic. | Mucormycosis is an angioinvasive disease caused by mold fungi of the genus Rhizopus, Mucor. India has reported surge in cases of COVID 19 associated Mucormycosis over the past few months due to the increasing frequency of risk factors like corticosteroid therapy, uncontrolled diabetes, neutropenia and obesity. Studies ... |
2,335,792 | Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse. | Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by a wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some of the key neuronal populations involved in daily torpor induction in mice, in particular, projections from the preop... |
2,335,793 | Comparative performance of verbal autopsy methods in identifying causes of adult mortality: A case study in India. | <AbstractText Label="BACKGROUND & OBJECTIVES">Cause of death assignment from verbal autopsy (VA) questionnaires is conventionally accomplished through physician review. However, since recently, computer softwares have been developed to assign the cause of death. The present study evaluated the performance of comput... |
2,335,794 | Comparison of Postoperative Pulmonary Outcomes in Patients Undergoing Cesarean Section under General and Spinal Anesthesia: A Single-Center Audit. | Regional anesthesia (RA), i.e., spinal or epidural anesthesia when performed for lower segment cesarean section (LSCS) provides excellent surgical conditions, avoiding manipulation of the maternal airway, maternal satisfaction, and good postoperative analgesia. However, in situations like fetal distress (fetal heart ra... |
2,335,795 | Effect of Injection Speed of Heavy Bupivacaine in Spinal Anesthesia on Quality of Block and Hemodynamic Changes. | Spinal anesthesia is a technique widely used for gynecological, lower abdominal, pelvic and lower limb procedures. Even though it causes a profound nerve block, it is associated with profound hypotension.</AbstractText>To assess the effect of the speed of injection of heavy bupivacaine on quality of block and hemodynam... |
2,335,796 | A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery. | Securing the airway in the surgery of maxillofacial disorders and traumas is fundamental during the operation. The present study aims to investigate the beneficial sedative effects of dexmedetomidine (DEX) in patients who underwent maxillofacial surgery with regional anesthesia compared to general anesthesia.</Abstract... |
2,335,797 | A selectivity filter mutation provides insights into gating regulation of a K<sup>+</sup> channel. | G-protein coupled inwardly rectifying potassium (GIRK) channels are key players in inhibitory neurotransmission in heart and brain. We conducted molecular dynamics simulations to investigate the effect of a selectivity filter (SF) mutation, G154S, on GIRK2 structure and function. We observe mutation-induced loss of sel... |
2,335,798 | The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis. | Doxorubicin is a chemotherapeutic medication commonly used to treat many types of cancers, but it has side effects including vomiting, rash, hair loss, and bone marrow suppression. The most dangerous side effects are cardiomyopathy, cardiofibrosis, and heart failure, as doxorubicin generates cytotoxicity and stops DNA ... |
2,335,799 | Exosomes: Potential executors of IL-35 gene-modified adipose-derived mesenchymal stem cells in inhibiting acute rejection after heart transplantation. | Heart transplantation has become the only 'cure' for end-stage heart diseases, but acute allograft rejection is the major obstacle to the survival of patients. Our previous studies showed that IL-35 gene-modified adipose-derived mesenchymal stem cells (IL-35-ASCs) can effectively inhibit graft rejection and prolong the... |
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