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2,335,800 | Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination - PCORnet, United States, January 2021-January 2022. | Cardiac complications, particularly myocarditis and pericarditis, have been associated with SARS-CoV-2 (the virus that causes COVID-19) infection (1-3) and mRNA COVID-19 vaccination (2-5). Multisystem inflammatory syndrome (MIS) is a rare but serious complication of SARS-CoV-2 infection with frequent cardiac involvemen... |
2,335,801 | Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial. | Dietary restriction of sodium has been suggested to prevent fluid overload and adverse outcomes for patients with heart failure. We designed the Study of Dietary Intervention under 100 mmol in Heart Failure (SODIUM-HF) to test whether or not a reduction in dietary sodium reduces the incidence of future clinical events.... |
2,335,802 | Determinants of Longitudinal Measure Pulse Rate of Chronic Heart Failure Patients at Felege Hiwot Referral Hospital, Ethiopia: A Longitudinal Modeling Data Analysis. | Heart rate is a significant modifiable factor in lowering mortality in heart failure patients. The heart rate, often known as the pulse rate, is the number of times the heart beats in a given amount of time. Irregular pulse rate or heart block are all measured using heart rate data. A higher heart rate has been associa... |
2,335,803 | Recent advances in the development of active hybrid molecules in the treatment of cardiovascular diseases. | Multifactorial nature of the underlying pathophysiology of chronic disorders hinders in the effective treatment and management of many complex diseases. The conventional targeted therapies have limited applications due to highly complicated disease etiology. Cardiovascular diseases (CVDs) are the group of disorders of ... |
2,335,804 | Cutaneous Neonatal Lupus Erythematosus: A Case Report. | Neonatal lupus erythematosus (NLE) is a rare autoimmune entity observed in infants born to mothers with autoantibodies against Ro/SSA and La/SSB. Neonatal lupus may present with rash, heart block, hepatic dysfunction, and cytopenia. Although the condition is usually self-limited, serious sequelae can occur. We present ... |
2,335,805 | Ultrasound-guided paravertebral nerve block anesthesia on the stress response and hemodynamics among lung cancer patients. | Thoracic surgery for radical resection of lung tumor requires deep anesthesia which can lead to an adverse inflammatory response, loss of hemodynamic stability, and decreased immune function. Herein, we evaluated the feasibility and benefits of ultrasound-guided paravertebral nerve block anesthesia, in combination with... |
2,335,806 | Comparing Duration of Analgesia after Intrathecal Administration of Opioids in Primary Paturients for Lower Segment Cesarean Section. | A pain free post operative period is a boon to mother for caring the neonate. We compared injection butorphanol and fentanyl as an adjuvant to bupivacaine in primary parturients for LSCS (Lower Segment Caesarean Section) with respect to duration of analgesia.</AbstractText>To study the effect of butorphanol vs fentanyl... |
2,335,807 | Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors and Combined SGLT1/2 Inhibitors on Cardiovascular, Metabolic, Renal, and Safety Outcomes in Patients with Diabetes: A Network Meta-Analysis of 111 Randomized Controlled Trials.<Pagination><StartPage>299</StartPage><EndPage>323</EndPage><MedlinePgn>299-323</Me... | Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of anti-hyperglycemic drugs that has been steadily increasing in popularity due to its cardiovascular and renal benefits. Dual SGLT1/SGLT2 (SGLT1/2) inhibitors have potentially augmented anti-hyperglycemic action due to additional SGLT1 inhibition. This netw... |
2,335,808 | Impact of socioeconomic deprivation on evaluation for heart transplantation at an urban academic medical center. | For patients with advanced heart failure, socioeconomic deprivation may impede referral for heart transplantation (HT). We examined the association of socioeconomic deprivation with listing among patients evaluated at our institution and compared this against the backdrop of our local community.</AbstractText>We conduc... |
2,335,809 | Environmental data and methods from the Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) core measures environmental working group. | This article describes geospatial datasets and exemplary data across five environmental domains (walkability, socioeconomic deprivation, urbanicity, personal safety, and food outlet accessibility). The environmental domain is one of four domains (behavioral, biological, environmental and psychosocial) in which the Accu... |
2,335,810 | Rucaparib versus standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation (ARIEL4): an international, open-label, randomised, phase 3 trial. | Few prospective studies have compared poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors to chemotherapy for the treatment of BRCA1-mutated or BRCA2-mutated ovarian carcinoma. We aimed to assess rucaparib versus platinum-based and non-platinum-based chemotherapy in this setting.</AbstractText>In this open-... |
2,335,811 | Effects of graduated compression socks on ankle inversion proprioception of half-marathon runners at different running distances.<Pagination><StartPage>529</StartPage><EndPage>534</EndPage><MedlinePgn>529-534</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jsams.2022.02.006</ELocationID><ELoca... | To determine the effect of graduated compression socks on ankle proprioception and the relationship between fatigue and ankle proprioception measures in half-marathon runners at successive 7 km intervals during a 21-km run.</AbstractText>Repeated measures study.</AbstractText>Twenty well-trained half-marathon ru... |
2,335,812 | [From the discovery of phlorizin (a Belgian story) to SGLT2 inhibitors]. | Most physicians do not know, or do not remember, the name of phlorizin. Hence this molecule has a major historical importance because it was the precursor of gliflozins, a new class of oral antidiabetic drugs with recent therapeutic perspectives beyond diabetes. This article recalls the history of phlorizin: its discov... |
2,335,813 | A Comparison of Two Peripheral Nerve Blocks Combined With General Anesthesia in Elderly Patients Undergoing Arthroplasty for Hip Fractures: A Pilot Randomized Controlled Trial. | Combined anesthesia can be a promising option for hip surgery when neuraxial anesthesia is contraindicated. Lumbar and sacral plexus blocks, and femoral nerve and lateral femoral cutaneous (LFC) nerve blocks in combination with general anesthesia (GA) are commonly used in elderly patients undergoing arthroplasty for hi... |
2,335,814 | A Comparison of Puncture and Continuous Pump Analgesia With Two Different Approaches to Thoracic Paravertebral Block for Thoracic Surgery. | This study aims to compare the success rate of thoracic paravertebral block (TPVB) and the effect of postoperative analgesia between two approaches.</AbstractText>A total of 34 patients with American Society of Anesthesiology (ASA) physical status score II-III, undergoing an optional thoracoscopic surgery, were randoml... |
2,335,815 | Impact of lung block shape on cardiac dose for total body irradiation. | Evaluating cardiac dose during total body irradiation (TBI) is of increasing interest. A three-dimensional beam model for TBI was commissioned and lung shielding was simulated in a treatment planning system with the cardiac silhouette partially blocked and unblocked. When blocked, the median heart dose decreased by 6% ... |
2,335,816 | Ultrasound-Guided Block of the Internal Branch of the Superior Laryngeal Nerve Reduces Postoperative Sore Throat Caused by Suspension Laryngoscopic Surgery: A Prospective Randomized Trial. | Suspension laryngoscopy is commonly used in operative laryngology. Although it is efficient and minimally invasive in most cases, it can lead to postoperative sore throat (POST) and cough. Because of intensive stimulation by the rigid metal suspension laryngoscope, procedures must be implemented under general anesthesi... |
2,335,817 | Investigating the Effect of the 10° Reverse Trendelenburg Position on Spinal Block Characteristics and Hemodynamic Parameters in Lower Limb Surgeries. | The primary goal of spinal anesthesia in lower limb surgeries is to achieve a successful sensory and motor block. Adequate level of spinal block for lower limb orthopedic surgery is T10. Due to multiple factors affecting the level of spinal anesthesia, it is not always easy to control the level of spinal anesthesia.We ... |
2,335,818 | Effectiveness of Breathing Exercises, Foot Reflexology and Massage (BRM) on Maternal and Newborn Outcomes Among Primigravidae in Saudi Arabia: A Randomized Controlled Trial. | Labor pain and anxiety are important concerns during labor, especially among the primigravidae. It may increase the duration of labor, increase stress hormones, and affect maternal and new-born related outcomes. This study examined the effectiveness of combined breathing exercises, foot reflexology, and massage (BRM) i... |
2,335,819 | Alpha-Calcitonin Gene Related Peptide: New Therapeutic Strategies for the Treatment and Prevention of Cardiovascular Disease and Migraine. | Alpha-calcitonin gene-related peptide (α-CGRP) is a vasodilator neuropeptide of the calcitonin gene family. Pharmacological and gene knock-out studies have established a significant role of α-CGRP in normal and pathophysiological states, particularly in cardiovascular disease and migraines. α-CGRP kno... |
2,335,820 | Analgesic effects of different concentrations of ropivacaine in transversalis fascia plane block during laparotomy. | To explore the analgesic effects of different concentrations of ropivacaine in transversalis fascia plane (TFP) block during laparotomy.</AbstractText>Ninety patients who underwent laparotomy admitted to our hospital from March 2019 to March 2020 were selected as the study subjects and were divided equally into a low c... |
2,335,821 | Cancer and palliative care in COVID-19 and other challenging situations-highlights from the Uganda Cancer Institute-Palliative Care Association of Uganda 3rd Uganda Conference on Cancer and Palliative Care, 23-24 September 2021, held in Kampala, Uganda and virtually. | The 3rd Uganda Conference on Cancer and Palliative Care was held in September 2021 with the theme: cancer and palliative care in COVID-19 and other challenging situations. It was hosted by the Uganda Cancer Institute and the Palliative Care Association of Uganda (UCI-PCAU). The conference was held virtually, with a mix... |
2,335,822 | The antidiabetic drug rosiglitazone blocks Kv1.5 potassium channels in an open state. | An antidiabetic drug, rosiglitazone is a member of the drug class of thiazolidinedione. Although restrictions on use due to the possibility of heart toxicity have been removed, it is still a drug that is concerned about side effects on the heart. We here examined, using Chinese hamster ovary cells, the action of rosigl... |
2,335,823 | Chemical Synthesis of a Functional Fluorescent-Tagged α-Bungarotoxin. | α-bungarotoxin is a large, 74 amino acid toxin containing five disulphide bridges, initially identified in the venom of <i>Bungarus multicinctus</i> snake. Like most large toxins, chemical synthesis of α-bungarotoxin is challenging, explaining why all previous reports use purified or recombinant α-bun... |
2,335,824 | Bilateral lumbar ultrasound-guided erector spinae plane block versus local anesthetic infiltration for perioperative analgesia in lumbar spine surgery: a randomized controlled trial. | Lumbar spinal surgery is associated with severe postoperative pain. We examined the analgesic efficacy of bilateral lumbar ultrasound-guided erector spinae plane block (ESPB) with ropivacaine compared with local infiltration.</AbstractText>Patients undergoing elective lumbar arthrodesis were randomly divided into two g... |
2,335,825 | Effects of Nalbuphine Combined with Anterior Serratus Plane Block in Elderly Patients Undergoing Thoracoscopic Surgery. | Postoperative pain in elderly patients with lung cancer after thoracoscopic surgery is still an important factor affecting the prognosis of patients. In this study, 200 elderly patients with lung cancer who were positive and planned to undergo video-assisted thoracoscopic surgery were randomly divided into four groups:... |
2,335,826 | Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle. | Serotonin (5-HT) is a multifaceted neurotransmitter that has been described to play a role as a peripheral inflammatory mediator when released in ischemic or injured muscle. Dorsal root ganglia (DRG) neurons are key sensors of noxious stimuli that are released under inflammatory conditions or mechanical stress. Little ... |
2,335,827 | [Efficacy-related substances of blood-activating and stasis-resolving medicinals derived from Curcuma plants: a review]. | Derived from Curcuma plants, Curcumae Longae Rhizoma, Curcumae Rhizoma, Wenyujin Rhizoma Concisum, and Curcumae Radix are common blood-activating and stasis-resolving medicinals in clinical practice, which are mainly used to treat amenorrhea, dysmenorrhea, chest impediment and heart pain, and rheumatic arthralgia cause... |
2,335,828 | Efficient Spatiotemporal Attention Network for Remote Heart Rate Variability Analysis. | Studies have shown that ordinary color cameras can detect the subtle color changes of the skin caused by the heartbeat cycle. Therefore, cameras can be used to remotely monitor the pulse in a non-contact manner. The technology for non-contact physiological measurement in this way is called remote photoplethysmography (... |
2,335,829 | Quality of Labor Analgesia with Dural Puncture Epidural versus Standard Epidural Technique in Obese Parturients: A Double-blind Randomized Controlled Study. | The dural puncture epidural technique may improve analgesia quality by confirming midline placement and increasing intrathecal translocation of epidural medications. This would be advantageous in obese parturients with increased risk of block failure. This study hypothesizes that quality of labor analgesia will be impr... |
2,335,830 | Patient privacy in smart cities by blockchain technology and feature selection with Harris Hawks Optimization (HHO) algorithm and machine learning. | A medical center in the smart cities of the future needs data security and confidentiality to treat patients accurately. One mechanism for sending medical data is to send information to other medical centers without preserving confidentiality. This method is not impressive because in treating people, the privacy of med... |
2,335,831 | <i>microRNA-135a-5p</i> regulates <i>NOD-like receptor family pyrin domain containing 3</i> inflammasome-mediated hypertensive cardiac inflammation and fibrosis <i>via thioredoxin-interacting protein</i>. | Hypertension is a severe public health problem that induces cardiac injury with alterations of gene expressions. The current study sought to evaluate the mechanism of <i>microRNA</i>(<i>miR)-135a-5p</i> in NOD-like receptor family pyrin domain containing 3 (<i>NLRP3</i>) inflammasome-mediation of cardiac inflammation a... |
2,335,832 | Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates. | Accumulating evidence indicates a link between gut barrier dysfunction and hypertension. However, it is unclear whether hypertension causes gut barrier dysfunction or vice versa and whether the gut microbiome plays a role. To understand this relationship, we first cross-sectionally examined 153 nonhuman primates [NHPs;... |
2,335,833 | Overcoming cognitive set bias requires more than seeing an alternative strategy. | Determining when to switch from one strategy to another is at the heart of adaptive decision-making. Previous research shows that humans exhibit a 'cognitive set' bias, which occurs when a familiar strategy occludes-even much better-alternatives. Here we examined the mechanisms underlying cognitive set by investigating... |
2,335,834 | The Median Effective Concentration (EC<sub>50</sub>) of Epidural Ropivacaine With Different Doses of Oxycodone During Limb Surgery in Elderly Patients. | Oxycodone can be used both intravenously and epidurally in elderly patients because of its strong analgesic effect and more slight respiratory inhibition compared with other opioids at the same effect. In this study, we determined the median effective concentration (EC50</sub>) of epidural ropivacaine required for grea... |
2,335,835 | Approach to Diagnostic Cytopathology of Serous Effusions. | Collection of most serous fluids from various effusions is a relatively simple procedure. Because of this, serous fluids are commonly submitted for pathologic examination including cytopathologic evaluation by various clinical institutions. As a consequence, even a general pathology laboratory which may not have expert... |
2,335,836 | Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero. | There is altered breastmilk composition among mothers with gestational diabetes and conflicting evidence on whether breastfeeding is beneficial or detrimental to their offspring's cardiometabolic health. We aimed to investigate associations between breastfeeding and offspring's cardiometabolic health across the range o... |
2,335,837 | Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is capable of inducing the activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome, a macromolecular structure sensing the danger and amplifying the inflammatory response. The main product processed by NLRP3 inflam... |
2,335,838 | A Randomised Controlled Trial to Assess the Analgesic Efficacy of Reduced Dose 0.2% Ropivacaine-Dexmedetomidine Combination Compared to Standard 0.375% Ropivacaine in USG Guided TAP Block for Paediatric Hernia Repair. | Paediatric pain management has remained understated practice over a period of time. Recently ultrasound-guided (USG) guided techniques are gaining popularity for perioperative analgesia, especially in the paediatric population. So, the aim of the present study was to evaluate the efficacy of reduced dose ropivacaine-de... |
2,335,839 | Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome. | Drug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the ventricular tachycardia known as torsades de pointes (TdP). In most cases of diLQTS, the primary molecular target is the human ether-à-go... |
2,335,840 | Enhanced Angiogenesis by 11βHSD1 Blockage Is Insufficient to Improve Reperfusion Following Hindlimb Ischaemia. | <b>Background:</b> Critical limb ischaemia (CLI), which is estimated to affect 2 million people in the United States, reduces quality of life, is associated with high morbidity and mortality, and has limited treatment options. Direct stimulation of angiogenesis using proangiogenic growth factors has been investigated a... |
2,335,841 | Gamma-Aminobutyric Acid Transporters in the Nucleus Tractus Solitarii Regulate Inhibitory and Excitatory Synaptic Currents That Influence Cardiorespiratory Function. | The brainstem nucleus tractus solitarii (nTS) processes and modulates the afferent arc of critical peripheral cardiorespiratory reflexes. Sensory afferents release glutamate to initiate the central component of these reflexes, and glutamate concentration is critically controlled by its removal <i>via</i> astrocytic neu... |
2,335,842 | Understanding contributors to racial and ethnic inequities in COVID-19 incidence and mortality rates. | Racial inequities in Coronavirus 2019 (COVID-19) have been reported over the course of the pandemic, with Black, Hispanic/Latinx, and Native American individuals suffering higher case rates and more fatalities than their White counterparts.</AbstractText>We used a unique statewide dataset of confirmed COVID-19 cases ac... |
2,335,843 | Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation. | Chronic carotid sinus nerve (CSN) electrical modulation through kilohertz frequency alternating current improves metabolic control in rat models of type 2 diabetes, underpinning the potential of bioelectronic modulation of the CSN as a therapeutic modality for metabolic diseases in humans. The CSN carries sensory infor... |
2,335,844 | Blocking TNF signaling may save lives in COVID-19 infection. | Global vaccination effort and better understanding of treatment strategies provided a ray of hope for improvement in COVID-19 pandemic, however, in many countries, the disease continues to collect its death toll. The major pathogenic mechanism behind severe cases associated with high mortality is the burst of pro-infla... |
2,335,845 | Health Status, Persistent Symptoms, and Effort Intolerance One Year After Acute COVID-19 Infection. | The long-term prevalence and risk factors for post-acute COVID-19 sequelae (PASC) are not well described and may have important implications for unvaccinated populations and policy makers.</AbstractText>To assess health status, persistent symptoms, and effort tolerance approximately 1 year after COVID-19 infection DESI... |
2,335,846 | Comparison of epidural analgesia with ultrasound-guided bilateral erector spinae plane block in aorto-femoral arterial bypass surgery. | Thoracic Epidural Analgesia (TEA) was compared with ultrasound-guided bilateral erector spinae plane (ESP) block in aorto-femoral arterial bypass surgery for analgesic efficacy, hemodynamic effects, and pulmonary rehabilitation.</AbstractText>Prospective randomized.</AbstractText>Tertiary care centre.</AbstractText>Adu... |
2,335,847 | Simultaneous Polar Metabolite and N-Glycan Extraction Workflow for Joint-Omics Analysis: A Synergistic Approach for Novel Insights into Diseases. | Bioinformatics and machine learning tools have made it possible to integrate data across different -omics platforms for novel multiomic insights into diseases. To synergistically process -omics data in an integrative manner, analyte extractions for each -omics type need to be done on the same set of clinical samples. T... |
2,335,848 | Physiological, Perceptual, and Performance Responses to the 2-Week Block of High- versus Low-Intensity Endurance Training. | This study examined the physiological, perceptual, and performance responses to a 2-wk block of increased training load and compared whether responses differ between high-intensity interval (HIIT) and low-intensity training (LIT).</AbstractText>Thirty recreationally trained males and females performed a 2-wk block of 1... |
2,335,849 | A novel 1-D densely connected feature selection convolutional neural network for heart sounds classification. | Heart sound auscultation, due to it being a non-invasive, convenient, and relatively low-cost technique, remains the dominant method for detection of cardiovascular disease.</AbstractText>In this paper, we present a method for identifying abnormal heart sounds based on a novel Dense Feature Selection Convolution Networ... |
2,335,850 | Perioperative Outcomes in COVID-19 Obstetric Patients Undergoing Spinal Anesthesia for Cesarean Section: A Prospective Observational Study. | Coronavirus disease 2019 (COVID-19) adds more challenges to the perioperative management of parturients. The aim of this study is to examine perioperative adverse events and hemodynamic stability among COVID-19 positive parturients undergoing spinal anesthesia. This prospective observational investigation was conducted... |
2,335,851 | Ultrasound-Guided Suprazygomatic Nerve Blocks to the Pterygopalatine Fossa: A Safe Procedure. | Large-scale procedural safety data on pterygopalatine fossa nerve blocks (PPFBs) performed via a suprazygomatic, ultrasound-guided approach are lacking, leading to hesitancy surrounding this technique. The aim of this study was to characterize the safety of PPFB.</AbstractText>This retrospective chart review examined t... |
2,335,852 | Value of advanced interatrial block in the diagnosis of the ischemic stroke's aetiology: A cohort study.<Pagination><StartPage>278</StartPage><EndPage>282</EndPage><MedlinePgn>278-282</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medcli.2021.11.012</ELocationID><ELocationID EIdType="pii" Val... | Coenzyme Q10 (CoQ10) is not FDA-approved to treat any medical condition, although it is widely available over-the-counter as a dietary supplement and recommended by primary care providers and specialists alike. Diseases such as neurodegenerative diseases, fibromyalgia, diabetes, cancer, mitochondrial diseases, muscular... |
2,335,853 | Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Administered as an Adjunct to Bupivacaine for Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgery. | Despite the growing interest in dexmedetomidine as an adjunct to truncal blocks, little is known about the systemic absorption of dexmedetomidine after these blocks and its role in analgesia and in hemodynamics.</AbstractText>We investigated the pharmacokinetics and pharmacodynamics of dexmedetomidine as an adjunct to ... |
2,335,854 | Counterion-insulated near-infrared dyes in biodegradable polymer nanoparticles for <i>in vivo</i> imaging. | Polymeric nanoparticles (NPs) are highly attractive for biomedical applications due to their potential biodegradability and capacity to encapsulate different loads, notably drugs and contrast agents. For <i>in vivo</i> optical bioimaging, NPs should operate in the near-infrared region (NIR) and exhibit stealth properti... |
2,335,855 | Subcutaneous ICD implantation under ultrasound-guided serratus anterior plane block: Single-center experience in the Netherlands. | To avoid general anesthesia (GA) and improve postoperative pain management for subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation there is a growing interest for alternative methods. We describe the first experience in the Netherlands of S-ICD implantation under Ultrasound-guided Serratus Anterior... |
2,335,856 | Loperamide-Induced Torsades de Pointes. | Loperamide, an over-the-counter antidiarrheal, works on the µ opioid receptor with minimal opioid activity if taken as directed. Recently, it has gained popularity as the "poor man's methadone" at supratherapeutic dosing. Opioid antagonism with naloxone is beneficial in reversing respiratory depress... |
2,335,857 | Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats. | Delta-opioid receptor is widely expressed in human and rodent hearts, and has been proved to protect cardiomyocytes against ischemia/reperfusion and heart failure. The antagonist of delta-opioid receptor could block the rescue effect of lipid emulsion against local anesthetic cardiotoxicity. However, no evidence is ava... |
2,335,858 | Dexmedetomidine as an adjunct to peripheral nerve blocks in pediatric patients. | Combining local anesthetics with dexmedetomidine (DEX) for nerve blocks has been tested and confirmed as an alternative technique to strengthen analgesia in adults, but the evidence supported this proposal in pediatrics was not convincing enough. Thus, we intend to conduct a meta-analysis to make an appraisal of the ef... |
2,335,859 | Comparison of effects of dexmedetomidine added to ropivacaine versus ropivacaine alone infiltration scalp block for attenuation of the haemodynamic response to skull pin placement in neurosurgical procedures: A double-blind, randomised clinical trial. | Skull pin head holder application is intensely painful and is accompanied with abrupt increase in heart rate and arterial blood pressure. We aimed to determine the effects of adding dexmedetomidine to ropivacaine scalp block in attenuating the haemodynamic response to skull pin insertion in neurosurgical procedures.</A... |
2,335,860 | Limb development genes underlie variation in human fingerprint patterns. | Fingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genome-wide scans in Han Chinese cohorts, we identified 18 loci associated with fingerprint type across the digits, including a genetic basis for the long-recognized "pattern-... |
2,335,861 | Effect of protein source and nonroughage NDF content in finishing diets of feedlot cattle fed free-choice hay on growth performance and carcass characteristics. | One-hundred twenty crossbreed steers (initial body weight (BW) 566 ± 42 kg) were used to evaluate the interaction of protein source (PS) and nonroughage NDF content (NRFC) in finishing diets of feedlot cattle fed free-choice hay on performance and carcass characteristics. Steers were stratified by BW and randomly ... |
2,335,862 | ANNet: A Lightweight Neural Network for ECG Anomaly Detection in IoT Edge Sensors.<Pagination><StartPage>24</StartPage><EndPage>35</EndPage><MedlinePgn>24-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1109/TBCAS.2021.3137646</ELocationID><Abstract><AbstractText>In this paper, we propose a lightw... | In this paper, we propose a lightweight neural network for real-time electrocardiogram (ECG) anomaly detection and system level power reduction of wearable Internet of Things (IoT) Edge sensors. The proposed network utilizes a novel hybrid architecture consisting of Long Short Term Memory (LSTM) cells and Multi-Layer P... |
2,335,863 | Prenatal predisposing factors associated with neonatal lupus erythematosus. | To identify the prenatal predisposing factors related to neonatal lupus erythematosus (NLE).</AbstractText>A retrospective case-control study was made of 131 pregnant women with positive anti-Ro or anti-La autoantibodies and known neonatal outcomes between January 2002 and December 2019 at Siriraj Hospital, Bangkok, Th... |
2,335,864 | Different Concentrations of Ropivacaine under Ultrasound Guidance on Quadratus Lumbar Muscle Nerve Block in Elderly Patients with Hip Replacement. | To compare the effect of ropivacaine in different concentrations under ultrasound guidance on lumbar muscle nerve blocking in elderly patients undergoing hip replacement surgery.</AbstractText>60 elderly patients underwent hip replacement in our hospital over a period of April to December of 2019 were equally randomize... |
2,335,865 | Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro. | Epidemic RNA viruses seem to arise year after year leading to countless infections and devastating disease. SARS-CoV-2 is the most recent of these viruses, but there will undoubtedly be more to come. While effective SARS-CoV-2 vaccines are being deployed, one approach that is still missing is effective antivirals that ... |
2,335,866 | Impact of Repeated Acute Exposures to Low and Moderate Exercise-Induced Hypohydration on Physiological and Subjective Responses and Endurance Performance. | This study aimed to examine whether repeated exposures to low (2%) and moderate (4%) exercise-induced hypohydration may reverse the potentially deleterious effect of hypohydration on endurance performance. Using a randomized crossover protocol, ten volunteers (23 years, V˙O<sub>2max</sub>: 54 mL∙kg<sup>-1<... |
2,335,867 | [Study on medication laws of traditional Chinese medicine of 48 patients with coronavirus disease 2019 in intensive care unit based on data mining].<Pagination><StartPage>1175</StartPage><EndPage>1180</EndPage><MedlinePgn>1175-1180</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3760/cma.j.cn121430-2... | Epicardial fat tissue (EFT) is a highly metabolically active fat depot surrounding the heart and coronary arteries that is related to early atherosclerosis and adverse cardiac events. We aimed to investigate the relationship between the amount of EFT and preexisting cardiac conduction abnormalities (CCAs) and the need ... |
2,335,868 | Encapsulation of doxorubicin prodrug in heat-triggered liposomes overcomes off-target activation for advanced prostate cancer therapy. | L-377,202 prodrug consists of doxorubicin (Dox) conjugated to a prostate-specific antigen (PSA) peptide substrate that can be cleaved by enzymatically active PSA at the tumor site. Despite the initial promise in phase I trial, further testing of L-377,202 (herein called Dox-PSA) was ceased due to some degree of non-spe... |
2,335,869 | Thoracic Spinal Angiolipomas: A Systematic Review. |  Spinal angiolipomas (SAs) are rare, benign tumors, representing 0.0004 to 1.2% of angiolipomas, usually located at the extradural and posterior thoracic level, with multimetameric extension.</AbstractText> A systematic literature review was performed according to the Preferred Reporting Items for Systema... |
2,335,870 | A systematic review and metanalysis of diagnostic yield of BAL for detection of SARS-CoV-2. | The gold standard for diagnosing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is microbiological confirmation by reverse transcriptase-polymerase chain reaction (RT-PCR)1</sup> most commonly done using oropharyngeal (OP) and nasopharyngeal swabs (NP). But in suspected cases, where these sample... |
2,335,871 | Fuzzy Logic Control of Heartrate by Electrical Block of Vagus Nerve. | Although vagus nerve stimulation (VNS) can be used to reduce heartrate by enhancing parasympathetic activity, a fully controllable intervention would also require a method for downregulating parasympathetic activity. A direct current (DC) block can be applied to a nerve to block its action potential conduction. This ne... |
2,335,872 | NONMMUT140591.1 may serve as a ceRNA to regulate Gata5 in UT-B knockout-induced cardiac conduction block. | We intended to explore the potential molecular mechanisms underlying the cardiac conduction block inducted by urea transporter (UT)-B deletion at the transcriptome level. The heart tissues were harvested from UT-B null mice and age-matched wild-type mice for lncRNA sequencing analysis. Based on the sequencing data, the... |
2,335,873 | The Efficacy and Safety of Ultrasound-Guided, Bi-Level, Erector Spinae Plane Block With Different Doses of Dexmedetomidine for Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial. | <b>Background:</b> The anesthetic characteristics of ultrasound-guided bi-level erector spinae plane block (ESPB) plus dexmedetomidine (Dex) remain unclear. We compared the efficacy and safety of ultrasound-guided bi-level ESPB plus different doses of Dex in patients undergoing video-assisted thoracic surgery (VATS). <... |
2,335,874 | Bayesian Regularized Strain Imaging for Assessment of Murine Cardiac Function In vivo. | A cardiac strain imaging framework with adaptive Bayesian regularization (ABR) is proposed for in vivo assessment of murine cardiac function. The framework uses ultrasound (US) radio-frequency data collected with a high frequency (f<sub>c</sub> = 30MHz) imaging system and a multi-level block matching algorithm with ABR... |
2,335,875 | The role of β<sub>2</sub> adrenergic receptor on infection development after ischaemic stroke. | Mechanisms underlying post-stroke immune impairments and subsequent development of fatal lung infection have been suggested to involve multiple pathways, including hyperactivation of the sympathetic nervous system (SNS), which results in the excessive release of catecholamines and activation of β-adrenergic recep... |
2,335,876 | Systemic erythematosus lupus and pregnancy outcomes in a Colombian cohort. | Pregnant women with SLE have higher probabilities of maternal complications. SLE during pregnancy has alternating patterns of remission and flare-ups; however, most pregnant SLE patients tend to worsen with associated poor obstetric and perinatal outcomes. This study aimed to describe obstetric outcomes in pregnant wom... |
2,335,877 | Psychobiological Correlates of Aggression in Female Adolescents with Borderline Personality Disorder. | Aggressive behavior in reaction to threats, frustration, or provocation is prevalent in borderline personality disorder (BPD). This study investigated aggressive behavior and its biological correlates in adolescents with BPD.</AbstractText>Twenty-one female adolescents with a DSM-IV BPD diagnosis and 25 sex- and age-ma... |
2,335,878 | The effect of ultrasound-guided low serratus anterior plane block on laparoscopic cholecystectomy postoperative analgesia: A randomized clinical trial. | Anterior serratus plane block for analgesia in many procedures, but there have been no reports of analgesia undergoing laparoscopic cholecystectomy (LC). We investigated the effects of ultrasonic-guided low serratory anterior block on patients undergoing LC.</AbstractText>One hundred patients who undergo LC were select... |
2,335,879 | Incidence of urethrocutaneous fistula following distal hypospadias repair with and without caudal epidural block: A randomized pilot study. | Recent investigations have raised a doubt regarding the safety of Caudal epidural block (CEB) administered to children with distal hypospadias undergoing tubularised incised plate (TIP) urethroplasty. The primary objective of the study was to investigate whether there is any association between CEB and the occurrence o... |
2,335,880 | Successful implantation of S-ICD using the intermuscular two-incision technique in a patient with severe pectus excavatum. | A patient with severe pectus excavatum, dilated ischemic heart disease, and indication for defibrillator implantation for primary prevention of sudden death underwent successful ultrasound-guided serratus anterior plane block and parasternal block with intermuscular two-incision technique implantation with no complicat... |
2,335,881 | Risk of seizure recurrence in people with single seizures and early epilepsy - Model development and external validation. | Following a single seizure, or recent epilepsy diagnosis, it is difficult to balance risk of medication side effects with the potential to prevent seizure recurrence. A prediction model was developed and validated enabling risk stratification which in turn informs treatment decisions and individualises counselling.</Ab... |
2,335,882 | Ultrasound-guided supra-inguinal fascia Iliaca compartment block for older adults admitted to the emergency department with hip fracture: a randomized controlled, double-blind clinical trial. | Hip fracture is common in older adults, and can cause severe post-fracture pain. Fascia iliaca nerve block has consequently been used for preoperative analgesia.</AbstractText>We performed a randomized, controlled, double-blind clinical trial and recruited older patients with hip fractures. These patients were randomiz... |
2,335,883 | Bachmann's bundle-ridge related biatrial tachycardia with a long epicardial circuit.<Pagination><StartPage>134</StartPage><EndPage>136</EndPage><MedlinePgn>134-136</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jce.15305</ELocationID><Abstract><AbstractText>Biatrial tachycardia (BiAT), involvin... | Biatrial tachycardia (BiAT), involving Bachmann's bundle in the circuit, has sometimes been observed after mitral anterior line ablation. In this article, we present a case of BiAT, involving a long epicardial circuit, composed of Bachmann's bundle and the left atrial ridge (LAR). We discuss the optimal ablation techni... |
2,335,884 | Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation. | Hydroxychloroquine, chloroquine and azithromycin are three drugs that were proposed to treat coronavirus disease 2019 (COVID-19). While concern already existed around their proarrhythmic potential, there are little data regarding how altered physiological states encountered in patients such as febrile state, electrolyt... |
2,335,885 | Quantitative Evaluation of Cardiac Cell Interactions and Responses to Cyclic Strain. | The heart has a dynamic mechanical environment contributed by its unique cellular composition and the resultant complex tissue structure. In pathological heart tissue, both the mechanics and cell composition can change and influence each other. As a result, the interplay between the cell phenotype and mechanical stimul... |
2,335,886 | Comparison of Thoracic Epidural Analgesia and Thoracic Paravertebral Block Applications in the Treatment of Acute Pain After Thoracotomy in Geriatric Patients. | Background Thoracic epidural analgesia (TEA) and thoracic paravertebral block (TPVB) are commonly used in geriatric patients for pain management after thoracotomy. In this study, we aimed to investigate the effect of TEA and TPVB on postoperative analgesia in geriatric patients who underwent thoracotomy. Methodology Po... |
2,335,887 | On the taxonomic validity of Indian ground spiders: V. Genera Megamyrmaekion Reuss, 1834, Sosticus Chamberlin, 1922 and Gaviphosa gen. nov. (Araneae: Gnaphosidae). | Indian Megamyrmaekion and Sosticus species are revised, mostly based on the type material available in the National Zoological Collection, Zoological Survey of India, Kolkata. The following new synonymies are recognised: Megamyrmaekion ashae syn. nov. is synonymised with Megamyrmaekion caudatum Reuss, 1834, Megamyrmaek... |
2,335,888 | Evaluation of the Analgesic Efficacy of Bilateral Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Post-Sternotomy Pain: A Randomized Controlled Trial. | Transverse thoracic block is a new perioperative analgesic method for post-sternotomy discomfort. This study discusses the efficacy of an ultrasound-guided transversus thoracic muscle plane block (TTPB) in patients undergoing heart surgery, including sternotomy.</AbstractText>In this prospective trial, 60 patients were... |
2,335,889 | Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women. | In terrestrial mammals, body volatiles can effectively trigger or block conspecific aggression. Here, we tested whether hexadecanal (HEX), a human body volatile implicated as a mammalian-wide social chemosignal, affects human aggression. Using validated behavioral paradigms, we observed a marked dissociation: Sniffing ... |
2,335,890 | Hemidiaphragmatic Paresis Following Interscalene Brachial Plexus Block With 2-Point Injection Technique. | An interscalene brachial plexus block is a commonly conducted nerve block for anesthesia and analgesia in shoulder surgery. Due to its proximity to the targeted nerve, the phrenic nerve, which innervates the diaphragm, is typically inadvertently blocked by ventral spread of the local anesthetic. Although hemidiaphragma... |
2,335,891 | Effects of 16 weeks of pyramidal and polarized training intensity distributions in well-trained endurance runners. | The aim of this study was to investigate the effects of four different training periodizations, based on two different training intensity distributions during a 16-week training block in well-trained endurance runners. Sixty well-trained male runners were divided into four groups. Each runner completed one of the follo... |
2,335,892 | Is Opioid-free Anesthesia Possible by Using Erector Spinae Plane Block in Spinal Surgery? | Erector spinae plane (ESP) block can be a method to be used for postoperative pain control in lumbar herniated disc operations. The aim of this study is to investigate the effect of erector spinae block in lumbar herniated disc operation on intraoperative and postoperative opioid consumption.</AbstractText>Sixty patien... |
2,335,893 | The analgesic effect and inflammatory mechanism of nonsteroidal analgesics combined with nerve block in post-gynecologic surgery patients. | To investigate the analgesic effect and inflammatory mechanism of nonsteroidal analgesics combined with nerve block in post-gynecologic surgery patients.</AbstractText>Sixty patients who underwent gynecological laparotomies in our hospital were enrolled in this retrospective cohort study, with 30 patients administered ... |
2,335,894 | Blockade of IL-6/IL-6R Signaling Attenuates Acute Antibody-Mediated Rejection in a Mouse Cardiac Transplantation Model. | Acute antibody-mediated rejection (AAMR) is an important cause of cardiac allograft dysfunction, and more effective strategies need to be explored to improve allograft prognosis. Interleukin (IL)-6/IL-6R signaling plays a key role in the activation of immune cells including B cells, T cells and macrophages, which parti... |
2,335,895 | Cardiac risk assessment with the Revised Cardiac Risk Index index before elective non-cardiac surgery: A retrospective audit from an Australian tertiary hospital. | Clinicians assessing cardiac risk as part of a comprehensive consultation before surgery can use an expanding set of tools, including predictive risk calculators, cardiac stress tests and measuring serum natriuretic peptides. The optimal assessment strategy is unclear, with conflicting international guidelines. We inve... |
2,335,896 | Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2. | Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were as... |
2,335,897 | Factors predicting difficult spinal block: A single centre study. | Several factors determine the success of dural puncture. We aimed to assess the association of first puncture success and number of attempts with characteristics of the patient, provider, technique and equipment.</AbstractText>This prospective, observational study was performed in 1647 adult patients undergoing surgery... |
2,335,898 | Inadvertent life-threatening total spinal anesthesia following caudal block in a preschool child underwent urologic surgery: A rare case report. | Caudal block is considered to be safe and provide optimal analgesia for pediatric patients undergoing sub-umbilical operations. It overcomes opioid-related side effects, particularly the dangers associated with respiratory depression in small children.</AbstractText>A 5-year-old male underwent uneventful hypospadias su... |
2,335,899 | Safety of Different Anesthesia Methods Combined with Intravenous Fast Channel Anesthesia in Lower Extremity Orthopedic Surgery of the Elderly. | To compare the safety of different anesthesia methods combined with intravenous fast channel anesthesia in elderly lower extremity surgery and the effect on postoperative outcome.</AbstractText>A total of 106 elderly patients who underwent lower extremity orthopedic surgery in our hospital from February 2018 to Februar... |
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