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11,800
Blood stream infection in patients undergoing systematic off-pump coronary artery bypass: incidence, risk factors, outcome, and associated pathogens.
Blood stream infection (BSI) is a major cause of mortality and morbidity for patients undergoing cardiac surgery. However, information is lacking about patients undergoing off-pump coronary artery bypass (OPCAB). The purpose of this study was to assess the incidence, risk factors, outcome and associated pathogens of BS...
11,801
Influence of mitral valve repair versus replacement on the development of late functional tricuspid regurgitation.
To study the determinants of functional tricuspid regurgitation (TR) progression after surgical correction of mitral regurgitation, including the influence of mitral valve (MV) repair (MVr) versus replacement (MVR) for degenerative mitral regurgitation.</AbstractText>From January 1995 to January 2006, 747 adults with M...
11,802
Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve).
Higher heart rate is associated with poorer outcomes in patients with heart failure and reduced ejection fraction (HF-REF). Less is known about the association between heart rate and outcomes in patients with heart failure and preserved ejection fraction (HF-PEF). Therefore, we examined the relationship between heart r...
11,803
Early repolarization increases the occurrence of sustained ventricular tachyarrhythmias and sudden death in the chronic phase of an acute myocardial infarction.
We recently showed that the presence of early repolarization (ER) increases the risk of ventricular fibrillation occurrences in the early phase of acute myocardial infarction (AMI). This study aimed to clarify whether an association exists between ER and occurrences of ventricular tachyarrhythmias or sudden death in th...
11,804
The impact of nonsustained ventricular tachycardia on reverse remodeling, heart failure, and treated ventricular tachyarrhythmias in MADIT-CRT.
This study determined whether the presence of nonsustained ventricular tachycardia (NSVT) was predictive of clinical events in MADIT-CRT (multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy) patients treated with CRT-defibrillator.</AbstractText>We analyzed 24-hour Holters for the p...
11,805
Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.
The HeartWare continuous flow ventricular assist device (HVAD) is used in an increasing number of heart failure patients. In those patients, ventricular arrhythmias (VAs) are common and, consequently, many patients already have an implanted implantable cardioverter defibrillator (ICD) in place or receive ICD implantati...
11,806
Ablation of epicardial ganglionated plexi increases atrial vulnerability to arrhythmias in dogs.
Previous studies have suggested that systematic ablation of ganglionated plexi (GP) could increase the short-term success rate of radiofrequency ablation for atrial fibrillation, but the long-term efficacy of this approach is not fully established.</AbstractText>Twenty-four mongrel dogs were divided into 3 groups: epic...
11,807
Back pain, leg swelling and a cardiac arrest: an interesting case of endocarditis.
A 66-year-old woman with a history of tissue aortic valve replacement and chronic back pain presented to the emergency department with a suspected right leg deep vein thrombosis. A recent outpatient MRI had revealed discitis. A ventricular fibrillation cardiac arrest occurred in the emergency department. Cardiac output...
11,808
Ca2+/calmodulin-dependent protein kinase II increases the susceptibility to the arrhythmogenic action potential alternans in spontaneously hypertensive rats.
Action potential duration alternans (APD-ALT), defined as long-short-long repetitive pattern of APD, potentially leads to lethal ventricular arrhythmia. However, the mechanisms of APD-ALT in the arrhythmogenesis of cardiac hypertrophy remain undetermined. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is known ...
11,809
Early repolarization as a predictor of arrhythmic and nonarrhythmic cardiac events in middle-aged subjects.
Early repolarization (ER) in the inferior/lateral leads predicts mortality, but whether ER is a specific sign of increased risk for arrhythmic events is not known.</AbstractText>The purpose of this study was to study the association of ER and arrhythmic events and nonarrhythmic morbidity and mortality.</AbstractText>We...
11,810
Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest.
During ischemia, enhancement of the "late Na+ current" (I(NaL)) contributes to intracellular Ca2+ overload. Dysregulation of intracellular Ca2+ homeostasis plays a critical role in the pathophysiology of cardiac arrest and cardiopulmonary resuscitation (CPR), leading to ventricular arrhythmias and left ventricle (LV) d...
11,811
I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis.
The purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI).</AbstractText>Forty-seven patients from a previous clinical trial we...
11,812
Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest.
In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated.</AbstractText>The aim of this...
11,813
[Cardiac disease at risk in the young athlete].
Physical training significantly reduces all cause mortality in the general population. Eligibility for competitive sport participation in athletes with cardiovascular diseases is based on recommendations. Incidence of sudden cardiac death in young athletes is low (0.5&#xa0;to 2/100,000&#xa0;athletes/year). The most com...
11,814
ST-segment elevation after direct current shock mimicking acute myocardial infarction: a case report and review of the literature.
External direct current (DC) shocks are and have long been commonly used for electrical cardioversion/defibrillation of atrial or ventricular arrhythmias. ST-segment elevation after cardio version with DC is an easily ignored phenomenon, occurring acutely and resolving during the first few minutes postshock. Here, we d...
11,815
A case of thyroid storm with cardiac arrest.
A 23-year-old man became unconscious while jogging. He immediately received basic life support from a bystander and was transported to our hospital. On arrival, his spontaneous circulation had returned from a state of ventricular fibrillation and pulseless electrical activity. Following admission, hyperthyroidism led t...
11,816
Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs.
Supplemental digital content is available in the text.</AbstractText>The aim of this experimental study was to compare survival and hemodynamic effects of a low-dose amiodarone and vasopressin compared with vasopressin in hypovolemic cardiac arrest model in piglets.</AbstractText>Eighteen anesthetized male piglets (wit...
11,817
Pathogenesis of arrhythmias in a model of CKD.
Patients with CKD have an increased risk of cardiovascular mortality from arrhythmias and sudden cardiac death. We used a rat model of CKD (Cy/+) to study potential mechanisms of increased ventricular arrhythmias. Rats with CKD showed normal ejection fraction but hypertrophic myocardium. Premature ventricular complexes...
11,818
Catheter ablation of electrical storm in a patient with left ventricular assist device.
Catheter ablation is an effective treatment for ventricular tachycardia (VT) in structural heart disease to reduce VT recurrence and implantable cardioverter defibrillator shocks.Current guidelines recommend ablation in patients with recurrent or incessant VT. In patients with left ventricular assist device (LVAD), VTs...
11,819
Left atrial appendage dysfunction in acute cerebral embolism patients with sinus rhythm: correlation with pulse wave tissue Doppler imaging.
To evaluate left atrial appendage (LAA) dysfunction using left atrial pulse-wave tissue Doppler imaging (PW-TDI) in acute cerebral embolism (ACE) patients with sinus rhythm (SR), transthoracic (TTE) and transesophageal echocardiograhy (TEE) were performed in 60 consecutive patients with SR without obvious left ventricu...
11,820
[Value of cardiopulmonary exercise test in cardiac function evaluation of patients with chronic left heart failure caused by dilated cardiomyopathy].
To assess the value of cardiopulmonary exercise test in the evaluation of cardiac function in patients with chronic left heart failure caused by dilated cardiomyopathy.</AbstractText>Fifty-three inpatients aged 18 year and over with chronic left heart failure caused by dilated cardiomyopathy at Fuwai Hospital from Octo...
11,821
The relationship between J wave on the surface electrocardiography and ventricular fibrillation during acute myocardial infarction.
We investigated whether the presence of J wave on the surface electrocardiography (sECG) could be a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction (AMI). We performed a retrospective study of 317 patients diagnosed with AMI in a single center from 2009 to 2012. Among the enro...
11,822
[Long-term survival of a patient with multiple myeloma-associated severe cardiac AL amyloidosis after implantation of a cardioverter-defibrillator].
Cardiac involvement is by far the most relevant factor impacting poor outcomes of patients with systemic light-chain (AL) amyloidosis. Median survival of patients with symptomatic cardiac AL amyloidosis is less than 6 months. Approximately two-thirds of these patients die suddenly due to ventricular arrhythmias and ele...
11,823
The effect of strict rate control on B-type natriuretic peptide values and echocardiographic parameters in chronic atrial fibrillation.
There have been conflicting results about the role of strict rate control on cardiovascular outcomes in patients with chronic atrial fibrillation (AF). To date, large clinical studies have not shown a net clinical benefit derived from the current trend to specify the target ventricular rate according to the patient's o...
11,824
Ten-year experience of an invasive cardiology centre with out-of-hospital cardiac arrest patients admitted for urgent coronary angiography.
The aim of the study was to evaluate survival and neurological function of out-of-hospital cardiac arrest (OHCA) patients admitted for urgent coronary angiography (UCA) with a view to percutaneous coronary intervention (PCI).</AbstractText>Hospital records of OHCA patients admitted to an invasive cardiology centre (pro...
11,825
Haemodynamic effects of etomidate, propofol and electrical shock in patients undergoing implantable cardioverter-defibrillator testing.
Anaesthetic drugs and internal electrical shock may alter the haemodynamic status of patients undergoing implantable cardioverter-defibrillator (ICD) testing. Comparative data on the mechanisms of etomidate and propofol-induced changes in haemodynamic parameters are inconsistent. Also the effects of ICD shock on haemod...
11,826
Unusual perforation of the left ventricle during radiofrequency catheter ablation for ventricular tachycardia.
Cardiac perforation during catheter-based radiofrequency ablation procedures is relatively uncommon but potentially fatal if tamponade ensues. This complication should be promptly recognised. We present a case of incomplete perforation of the left ventricle with transient ST-segment elevation in leads V1 to V3 during c...
11,827
Fragmented QRS can predict severity of aortic stenosis.
Fragmented QRS (fQRS) is an indicator of nonhomogeneous ventricular activity caused by myocardial fibrosis. Aortic stenosis (AS) is known to be a cause of myocardial fibrosis. We aimed to investigate the relationship of fQRS with severity of AS, echocardiographic, and electrocardiographic findings, and development of a...
11,828
New oral anticoagulants vs vitamin K antagonists: benefits for health-related quality of life in patients with atrial fibrillation.
New oral anticoagulants (NOAC) have demonstrated their efficacy as an alternative to vitamin K antagonists (VKA) in the prophylaxis of cardioembolic events in patients with atrial fibrillation (AF). However, evidence on the benefits of NOAC in health-related quality of life (HRQoL) is lacking.We evaluated changes in HR...
11,829
Catheter ablation in patients with electrical storm: benefit of a network of cooperating clinics.
Catheter ablation has been shown to be an effective treatment for rhythm stabilization in patients with multiple ventricular arrhythmia episodes called electrical storm (ES). These procedures may be complex and are usually only performed in highly specialized and experienced centers. Still the optimum timing for cathet...
11,830
Predictors of functional outcome after intraoperative cardiac arrest.
Few outcome data are available about intraoperative cardiac arrest (IOCA). The authors studied 90-day functional outcomes and their determinants in patients admitted to the intensive care unit after IOCA.</AbstractText>Patients admitted to 11 intensive care units in a period of 2000-2013 were studied retrospectively. T...
11,831
Efficacy of long detection interval implantable cardioverter-defibrillator settings in secondary prevention population: data from the Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients III (ADVANCE III) trial.
Three trials demonstrated recently that a long detection window reduces implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients. Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients III (ADVANCE III) was the only trial that enrolled both primary and secondary prevention pa...
11,832
B-type natriuretic peptide is a major predictor of ventricular tachyarrhythmias.
The cost-effective use of implantable cardioverter-defibrillators (ICDs) for the prevention of sudden cardiac death requires identification of patients at risk for ventricular tachyarrhythmias, not just for total mortality.</AbstractText>To determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) or B-ty...
11,833
Renal disease and left atrial remodeling predict atrial fibrillation in patients with cardiovascular risk factors.
In this prospective population-based study, we tested the possible interaction between chronic kidney disease (CKD) and left atrium volume index (LAVI) in predicting incident atrial fibrillation (AF).</AbstractText>We enrolled 3549 Caucasian subjects, 1829 men and 1720 women, aged 60.7 &#xb1; 10.6 years, without baseli...
11,834
Beau's Lines After Cardiac Arrest.
A 34-year-old man with uncontrolled hypertension suffered a ventricular fibrillation cardiac arrest from an obstructive left anterior descending artery occlusion. He was defibrillated more than 10 times before achieving return of spontaneous circulation. He was comatose after his arrest and was treated with therapeutic...
11,835
Malignant arrhythmia as the first manifestation of Wolff-Parkinson-White syndrome: a case with minimal preexcitation on electrocardiography.
Wolff-Parkinson-White (WPW) syndrome is defined as the presence of an accessory atrioventricular pathway which is manifested as delta waves and short PR interval on electrocardiography (ECG). However, some WPW cases do not have typical findings on ECG and may remain undiagnosed unless palpitations occur. Sudden cardiac...
11,836
Left ventricular hypertrophy and antiarrhythmic drugs in atrial fibrillation: impact on mortality.
Despite sparse clinical data, current atrial fibrillation (AF) guidelines favor amiodarone as a drug of choice for patients with left ventricular hypertrophy (LVH).</AbstractText>This study tested the hypothesis that patients with persistent AF and LVH on nonamiodarone antiarrhythmics have higher mortality compared to ...
11,837
[Dual AV nodal nonreentry tachycardia (DAVNNT): unrecognized differential diagnosis with far-reaching consequences].
The dual atrioventricular nodal nonreentry tachycardia (DAVNNT) is a rare form of tachycardia which occurs due to a time delayed double antegrade conduction via the slow and fast atrioventricular nodal pathways. Its epidemiology is not known so far. The aim of this article is to present the clinical findings in a serie...
11,838
Short QT in a cohort of 1.7 million persons: prevalence, correlates, and prognosis.
Short QT syndrome (QTc &#x2264; 300 ms) is a novel hereditary channelopathy linked to syncope, paroxysmal atrial fibrillation, and sudden cardiac death. However, its epidemiological features remain unsettled.</AbstractText>(1) To assess the prevalence of short QT in a large population-based sample; (2) to evaluate its ...
11,839
Putting class IIb recommendations to the test: the influence of unwitnessed and Non-VT/VF arrests on resource consumption and outcomes in therapeutic hypothermia and targeted temperature management.
Therapeutic hypothermia (TH) and targeted temperature management improve neurologic recovery, and survival for patients resuscitated from witnessed out-of-hospital ventricular tachycardia (VT) and ventricular fibrillation (VF) cardiac arrest. The American Heart Association recently gave a class IIb recommendation for t...
11,840
NT-proBNP in the mitral valve surgery.
Prognosis and severity of mitral valve disease in patients are reflected in their natriuretic peptide levels. Patients in the upper margin of this range with severe mitral valve dysfunction also present with a range of myocardial dysfunction and symptomatic progression. We investigated whether serial pre- and immediate...
11,841
Mitral valve prolapse and electrolyte abnormality: a dangerous combination for ventricular arrhythmias.
A 27-year-old woman with a history of bileaflet mitral valve prolapse and moderate mitral regurgitation presented to our emergency with untractable polymorphic wide complex tachycardia and unstable haemodynamics. After cardiopulmonary resuscitation, return of spontaneous circulation was achieved 30 min later. Her post-...
11,842
Late Presentation of Recurrent Monomorphic Ventricular Tachycardia following Minimally Invasive Mitral Valve Repair due to Epicardial Injury.
We report a 73-year-old male with late onset monomorphic ventricular tachycardia following mitral valve repair (MVR). Typically, injury to epicardial arteries following mitral valve repair/replacement presents immediately as ventricular tachycardia/fibrillation, difficulty weaning from cardiopulmonary bypass, worsening...
11,843
[Electrical storm in ICD patients: prevention and treatment].
Medical progress and demographic changes cause a continuous increase in patients with implantable cardioverter-defibrillators (ICD). Up to one third of patients with ICDs for secondary prevention and half of the patients with previous electrical storm (ES) will suffer from (further) ESs. When multiple ICD shocks are re...
11,844
The vernakalant story: how did it come to approval in Europe and what is the delay in the U.S.A?
The sudden onset of atrial fibrillation (AF) is often associated with rapid irregular palpitations, chest pain, shortness of breath and considerable anxiety. If a patient presents shortly after the onset of the arrhythmia the physician may adopt initially an expectant "wait and see" policy, perhaps with the help of mil...
11,845
[Catheter ablation of electrical storm: ready for prime time?].
Electrical storm is an increasingly recognized clinical entity. It is generally defined as the occurrence of &#x2265;&#x2009;3 episodes of potentially life-threatening ventricular arrhythmias during a time span of 24 h. Apart from pharmacological treatment options, catheter ablation remains a relatively novel, promisin...
11,846
Effect of novel modified bipolar radiofrequency ablation for preoperative atrial fibrillation combined with off-pump coronary artery bypass grafting surgery.
We described a novel modified bipolar radiofrequency (RF) ablation for preoperative atrial fibrillation (AF) combined with off-pump coronary artery bypass grafting (OPCABG) for patients with AF and coronary artery disease (CAD). The aim of this study was to assess the effect of this novel procedure and to determine whe...
11,847
Epidemiological characteristics of sudden cardiac arrest in schools.
The present study aimed to clarify the incidence and outcomes of sudden cardiac arrests in schools and the clinically relevant characteristics of individuals who experienced sudden cardiac arrests.</AbstractText>We obtained data on sudden cardiac arrests that occurred in schools between January 1, 2005 and December 31,...
11,848
Usefulness of left ventricular diastolic function to predict recurrence of atrial fibrillation in patients with preserved left ventricular systolic function.
It is unknown whether recurrence of atrial fibrillation (AF) is related to severity of left ventricular diastolic dysfunction (LVDD) before ablation in patients with preserved left ventricular ejection fraction (LVEF). We tested the hypothesis that the presence and/or severity of LVDD before catheter ablation are relat...
11,849
Occurrence of cardiac arrhythmias in Standardbred racehorses.
Cardiac arrhythmias are a recognised but poorly characterised problem in the Standardbred racehorse. Frequency data could aid the development of cardiac arrhythmia screening programmes.</AbstractText>To characterise the occurrence of cardiac arrhythmias in Standardbreds prior to racing and in the late post race period ...
11,850
Short QT syndrome manifesting with neonatal atrial fibrillation and bradycardia.
Atrial fibrillation (AF) is rare during childhood and usually associated with other cardiovascular pathology. In lone AF, the ventricular response rate is usually rapid. We sought to describe a subset of children who present with early-onset AF and a slow ventricular response rate who were found to have the short QT sy...
11,851
ICD programming to reduce shocks and improve outcomes.
Despite the clinical benefit of implantable cardioverter defibrillator (ICD), there is a high frequency of inappropriate ICD therapy associated with impaired quality of life, unwanted health care resource utilization, and adverse clinical outcome. Alternative strategies of ICD programming are needed to reduce the risk ...
11,852
Upper limit of vulnerability during defibrillator implantations predicts the occurrence of appropriate shock therapy for ventricular fibrillation.
The utility of the upper limit of vulnerability (ULV) test in patients undergoing defibrillator implantation has been reported, so the purpose of this study was to evaluate the difference in the clinical outcomes between patients with ULV &#x2264;15 J or &gt;15 J.</AbstractText>A total of 165 patients receiving an impl...
11,853
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.
Small-conductance calcium-activated potassium (SK) channels are expressed in the heart of various species, including humans. The aim of the present study was to address whether SK channels play a functional role in human atria.</AbstractText>Quantitative real-time PCR analyses showed higher transcript levels of SK2 and...
11,854
Slow adaptation of ventricular repolarization as a cause of arrhythmia?
This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems".</AbstractText>Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation of action ...
11,855
Rapid expansion of mycotic aneurysm of left coronary sinus of Valsalva causing&#xa0;myocardial ischemia: report of a case.
We described a 71-year-old female of aneurysm of the left sinus of Valsalva from mycotic origin. She underwent aortic valve replacement 11&#xa0;years ago. Repeated CT scans showed rapidly growing aneurysm below the left coronary ostium. On sixth day after the admission, she suddenly developed myocardial ischemia compli...
11,856
Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture.
We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations ...
11,857
Short stature and ischemic stroke in nonvalvular atrial fibrillation: new insight into the old observation.
For decades, repeated epidemiologic observations have been made regarding the inverse relationship between stature and cardiovascular disease, including stroke. However, the concept has not been fully evaluated in patients with atrial fibrillation (AF). We investigated whether patient's height is associated with ischem...
11,858
Postcardioplegia ventricular fibrillation: no impact on subsequent survival.
At aortic declamping after cardioplegic cardiac arrest, the initial rhythm can be broadly classified as ventricular fibrillation (VF) or non-VF. VF can be treated with potassium-induced conversion and direct-current countershock is only applied if potassium treatment fails. We aimed to investigate whether there are any...
11,859
Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes.
Brugada syndrome and idiopathic ventricular fibrillation (VF) associated with inferolateral early repolarization patterns are termed "J-wave syndromes." In such patients, an implantable cardioverter-defibrillator (ICD) is first-line therapy for prevention of sudden cardiac death. However, frequent ICD shocks due to rec...
11,860
Implantable cardioverter defibrillator system with floating atrial sensing dipole: a single-center experience.
The concept of a single-lead dual-chamber implantable cardioverter defibrillator (ICD) with floating sensing atrial dipole has been proven safe and functional. We report a single-center experience with this ICD system; the major focus of the work is on the recorded atrial activation and its stability on a medium term f...
11,861
Sudden cardiac arrest at the finish line: in coronary ectopia, the cause of ischemia is from intramural course, not ostial location.
A 26-year-old woman, a well-trained runner, had a sudden cardiac arrest just before crossing the finish line of a marathon. She was rapidly resuscitated and was later found to have an ectopic origin of the left coronary artery. This anomaly was surgically repaired by translocating the ostium from the right to the left ...
11,862
Takotsubo cardiomyopathy as a sequela of elective direct-current cardioversion for atrial fibrillation.
In takotsubo cardiomyopathy, the clinical appearance is that of an acute myocardial infarction in the absence of obstructive coronary artery disease, with apical ballooning of the left ventricle. The condition is usually precipitated by a stressful physical or psychological experience. The mechanism is unknown but is t...
11,863
Bileaflet versus posterior-leaflet-only preservation in mitral valve replacement.
In the present study of mitral valve replacement, we investigated whether complete preservation of both leaflets (that is, the subvalvular apparatus) is superior to preservation of the posterior leaflet alone. Seventy patients who underwent mitral valve replacement in our clinic were divided into 2 groups: MVR-B (n=16)...
11,864
Distinctive patterns of dominant frequency trajectory behavior in drug-refractory persistent atrial fibrillation: preliminary characterization of spatiotemporal instability.
The role of substrates in the maintenance of persistent atrial fibrillation (persAF) remains poorly understood. The use of dominant frequency (DF) mapping to guide catheter ablation has been proposed as a potential strategy, but the characteristics of high DF sites have not been extensively studied. This study aimed to...
11,865
Predictors for cardiac resynchronization therapy response: the importance of QRS morphology and left ventricular lead position.
Although cardiac resynchronization therapy (CRT) is a well-established treatment for a subset of patients with chronic heart failure, a considerable proportion of eligible patients still fail to benefit from this treatment. The aim of this study was to identify potential independent predictors for being a responder to ...
11,866
Atrial fibrillation burden in Myotonic Dystrophy type 1 patients implanted with dual chamber pacemaker: the efficacy of the overdrive atrial algorithm at 2 year follow-up.
The role that atrial pacing therapy plays on the atrial fibrillation (AF) burden is still unclear. Aim of the study was to evaluate the effect of the atrial preference pacing algorithm on AF burden in patients affected by Myotonic Dystrophy type 1 (DM1) followed for a long follow up period. Sixty DM1 patients were -imp...
11,867
Factors responsible for elevated plasma B-type natriuretic peptide levels in severe aortic stenosis: comparison between elderly and younger patients.
Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We hypothesized that plasma BNP levels may be i...
11,868
Postresuscitation hemodynamics during therapeutic hypothermia after out-of-hospital cardiac arrest with ventricular fibrillation: a retrospective study.
To evaluate the incidence of postresuscitation myocardial depression (PRMD) and hemodynamical parameters associated with PRMD in patients treated with therapeutic hypothermia (TH) after out-of-hospital cardiac arrest with ventricular fibrillation (OHCA-VF).</AbstractText>Analysis of hemodynamical data from computerized...
11,869
Incidence and prognostic significance of silent atrial fibrillation in acute myocardial infarction.
Silent atrial fibrillation (AF) has been suggested to be frequent after acute myocardial infarction (MI). Continuous ECG monitoring (CEM) has been shown to improve AF screening in patients at risk of stroke.</AbstractText>We aimed to assess the incidence and prognosis of silent AF in patients with acute MI.</AbstractTe...
11,870
Elevated brain natriuretic peptide level in patients undergoing atrial fibrillation ablation: is it a predictor of failed ablation or a mere function of atrial rhythm and rate at a point in time?
Pre- and postablation atrial fibrillation (AF) brain natriuretic peptide (BNP) levels were shown to predict increased recurrence of AF following ablation.</AbstractText>Our objective was to assess whether elevated BNP levels merely represent the presence of AF at the time of measurement or indeed the true recurrence of...
11,871
Implantable cardioverter defibrillator during laser transurethral resection of the prostate.
&#xa0; Implantable cardioverter defibrillators have been instrumental in the health and safety of patients who are at increased risk of sudden death by ventricular tachycardia or fibrillation. Consensus on the perioperative management of cardiovascular implantable electronic devices has suggested that certain surgical ...
11,872
New insights into defibrillation of the heart from realistic simulation studies.
Cardiac defibrillation, as accomplished nowadays by automatic, implantable devices, constitutes the most important means of combating sudden cardiac death. Advancing our understanding towards a full appreciation of the mechanisms by which a shock interacts with the heart, particularly under diseased conditions, is a pr...
11,873
Heart rate turbulence for predicting new-onset atrial fibrillation in patients undergoing coronary artery bypass grafting.
Cardiac autonomic dysfunction reportedly contributes to the AF triggering and maintenance. Heart rate turbulence (HRT) is a promising noninvasive measure of cardiac autonomic function. We investigated whether ambulatory ECG-based HRT measurement could predict in-hospital new-onset atrial fibrillation (AF) after coronar...
11,874
Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial.
Patients with a pacing indication and first-degree atrioventricular (AV)-block pose a clinical challenge. The prognostic impact of first-degree AV-block in patients with sinus node dysfunction and the impact of pacing in this setting are not known.</AbstractText>In the Mode Selection Trial (MOST), 2,010 patients with s...
11,875
Clinical benefit of cardiac resynchronization therapy with a defibrillator in patients with an ejection fraction &gt; 35% estimated by cardiac magnetic resonance.
Cardiac resynchronization therapy with a defibrillator prolongs survival and improves quality of life in advanced heart failure. Traditionally, patients with ejection fraction &gt; 35 estimated by echocardiography have been excluded. We assessed the prognostic impact of this therapy in a group of patients with severely...
11,876
Influence of left ventricular remodeling on atrial fibrillation recurrence and cardiovascular hospitalizations in patients undergoing rhythm-control therapy.
Atrial fibrillation (AF) patients with left ventricular hypertrophy (LVH) and diastolic dysfunction may derive benefit from being in sinus rhythm but no data are available to support this strategy in them. We sought to investigate effect of left ventricular remodeling on cardiovascular outcomes in AF patients undergoin...
11,877
Anesthesia for a child with Walker-Warburg syndrome.
Walker-Warburg Syndrome is a rare, autosomal recessive congenital muscular dystrophy manifested by central nervous system, eye malformations and possible multisystem involvement. The diagnosis is established by the presence of four criteria: congenital muscular dystrophy, type II lissencephaly, cerebellar malformation,...
11,878
Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans.
This study mapped human ventricular fibrillation (VF) to define mechanistic differences between episodes requiring defibrillation versus those that spontaneously terminate.</AbstractText>VF is a leading cause of mortality; yet, episodes may also self-terminate. We hypothesized that the initial maintenance of human VF i...
11,879
The role of the wearable cardioverter defibrillator in clinical practice.
The wearable cardioverter defibrillator (WCD) is an option for external monitoring and defibrillation in patients at risk for sudden cardiac arrest caused by ventricular tachycardia or ventricular fibrillation and who are not candidates for or who refuse an implantable cardioverter defibrillator (ICD). WCDs provide mon...
11,880
The totally subcutaneous implantable defibrillator.
The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a new therapeutic option for patients at risk of sudden cardiac arrest. The device uses a pulse generator implanted in the lateral thoracic region and a tunneled subcutaneous electrode. Benefits of this configuration include the preservation of venous a...
11,881
Is defibrillation testing necessary?
With advancements in implantable cardioverter defibrillator (ICD) technology, the practice of performing defibrillation threshold (DFT) testing at the time of implantation has been questioned. With availability of biphasic waveforms, active cans, and high-output devices, opponents claim that DFT testing is no longer ne...
11,882
Sudden cardiac arrest recorded during Holter monitoring: prevalence, antecedent electrical events, and outcomes.
Causative arrhythmias of sudden cardiac arrest (SCA) are changing in this age of improved coronary care.</AbstractText>The purpose of this study was to examine the frequency of terminal arrhythmias and the electrical events prior to SCA.</AbstractText>We analyzed 24-hour Holter recordings of 132 patients enrolled from ...
11,883
Usefulness of electrocardiographic parameters for risk prediction in arrhythmogenic right ventricular dysplasia.
The value of electrocardiographic findings predicting adverse outcome in patients with arrhythmogenic right ventricular dysplasia (ARVD) is not well known. We hypothesized that ventricular depolarization and repolarization abnormalities on the 12-lead surface electrocardiogram (ECG) predict adverse outcome in patients ...
11,884
Limitations of the AutoCapture&#x2122; Pacing System in patients with cardiac stimulation devices.
AutoCapture (St Jude Medical) is a technological development that confirms ventricular capture analysing the evoked response after a pacing impulse and adjusts the energy output to changes in the stimulation threshold. Although this algorithm is aimed to assure capture minimizing energy consumption, some patients might...
11,885
Pseudo-ventricular tachycardia mimicking malignant arrhythmia in a patient with rapid atrial fibrillation.
Artifacts can simulate arrhythmias such as atrial flutter, atrial fibrillation, and ventricular tachycardia. A case of pseudo-ventricular tachycardia is outlined in a patient with newly diagnosed atrial fibrillation, which made the diagnosis a special challenge. Characteristic signs of pseudo-ventricular tachycardia ar...
11,886
Efficacy of a new class III drug niferidil in cardioversion of persistent atrial fibrillation and flutter.
To study the efficacy and safety of the new class III antiarrhythmic agent niferidil for pharmacological cardioversion in patients with persistent atrial fibrillation (AF) and atrial flutter (AFl).</AbstractText>One hundred thirty-four adults (aged 57.8 &#xb1; 11 years, 90 males) were included with median AF duration o...
11,887
Prevalence and clinical correlation of left ventricular systolic dysfunction in african americans with ischemic stroke.
The goal of the present study was to determine the prevalence of left ventricular systolic dysfunction (LVSD) and associated clinical correlates in African Americans (AA) diagnosed with ischemic stroke (IS).</AbstractText>Retrospective chart analysis was done on all diagnosed AA IS patients between January 2010 and Mar...
11,888
Hemodynamic-directed cardiopulmonary resuscitation during in-hospital cardiac arrest.
Cardiopulmonary resuscitation (CPR) guidelines assume that cardiac arrest victims can be treated with a uniform chest compression (CC) depth and a standardized interval administration of vasopressor drugs. This non-personalized approach does not incorporate a patient's individualized response into ongoing resuscitative...
11,889
Is recent cannabis use associated with acute coronary syndromes? An illustrative case series.
Cannabis is a frequently used recreational drug that potentially imposes serious health problems. We report three cases where recent and/or chronic use of marijuana led to severe cardiac dysfunction. All three patients collapsed at home and required cardiopulmonary resuscitation (CPR) with initial restoration of sponta...
11,890
Outcome comparison of African-American and Caucasian patients with severe aortic stenosis subjected to transcatheter aortic valve replacement: a single-center experience.
This study aimed to report the outcomes of African Americans (AAs) in the US undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS).</AbstractText>Compared to Caucasians, AAs are reported to have poorer outcomes from most cardiovascular diseases, including high complication rates after...
11,891
Incidence of syncope and cardiac arrest in patients with severe aortic stenosis.
&#xa0;Syncope and sudden cardiac arrest are known complications of aortic stenosis (AS).</AbstractText>&#xa0;The aim of the study was to investigate the incidence of these complications in patients with severe symptomatic AS and to analyze whether basic clinical data and electrocardiographic (ECG) and echocardiographic...
11,892
Cardiac arrhythmia and death of teenager linked to rare genetic disorder diagnosed at autopsy.
A 17-year-old male adolescent sustained cardiac arrest after participating in a wrestling match, where he was thrown down. He had no pulse, and cardiopulmonary resuscitation was immediately initiated along with application of an automatic external defibrillator. Upon arrival of emergency medical services, an electrocar...
11,893
[Prediction of outcome of the acute period of ischemic stroke in young and middle-aged patients].
Objectives. To find out cardiovascular risk factors and the effect of atherosclerotic lesions of carotid arteries on the level of disability of young and middle-aged patients to the end of the acute period of ischemic stroke (II). Material and methods. A study included 266 patients, aged from 25 to 59 years, with a fir...
11,894
Early eplerenone treatment in patients with acute ST-elevation myocardial infarction without heart failure: the Randomized Double-Blind Reminder Study.
We aimed to assess the impact of eplerenone on cardiovascular (CV) outcomes in STEMI without known heart failure, when initiated within 24 h of symptom onset.</AbstractText>In this randomized, placebo-controlled, double-blind trial, we assigned 1012 patients with acute STEMI and without a history of heart failure to re...
11,895
Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.
In cardiomyocytes from failing hearts, insufficient mitochondrial Ca(2+) accumulation secondary to cytoplasmic Na(+) overload decreases NAD(P)H/NAD(P)(+) redox potential and increases oxidative stress when workload increases. These effects are abolished by enhancing mitochondrial Ca(2+) with acute treatment with CGP-37...
11,896
Use of therapeutic hypothermia and extracorporeal life support after an unusual response to the ajmaline challenge in a patient with Brugada syndrome.
Brugada syndrome is a cardiac disorder associated with a high risk of sudden cardiac death, especially in young subjects. The incidence and prevalence are likely underestimated. The diagnosis is based on a characteristic electrocardiography (ECG) pattern. The most commonly performed confirmatory test in cases of equivo...
11,897
Device-Based Approaches to Modulate the Autonomic Nervous System and Cardiac Electrophysiology.
Alterations in resting autonomic tone can be pathogenic in many cardiovascular disease states, such as heart failure and hypertension. Indeed, autonomic modulation by way of beta-blockade is a standard treatment of these conditions. There is a significant interest in developing non-pharmacological methods of autonomic ...
11,898
Use of Cardiac Resynchronisation Therapy - Change of Clinical Settings.
Current guidelines recommend cardiac resynchronisation therapy (CRT) for patients with severe left ventricular dysfunction (left ventricular ejection fraction [LVEF] &#x2264;35 %), QRS duration of &#x2265;120-150 ms (Class IA and IB indications) on surface electrocardiogram (ECG) and New York Heart Association (NYHA) c...
11,899
Effect Of Catheter Ablation On Quality Of Life In Atrial Fibrillation.
Atrial fibrillation (AF) is the most common sustained arrhythmia seen in clinical practice, affecting approximately 1% of the overall population. While rarely life-threatening, AF is almost universally associated with increased morbidity and mortality, predominantly through an increased risk of thromboembolic events, l...