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12,900
Implantable cardioverter-defibrillators in lamin A/C mutation carriers with cardiac conduction disorders.
Sudden cardiac death is frequent in patients with lamin A/C gene (LMNA) mutations and may be related to ventricular arrhythmias (VA).</AbstractText>To evaluate a strategy of prophylactic implantable cardioverter-defibrillator (ICD) implantation in LMNA mutation carriers with significant cardiac conduction disorders.</A...
12,901
Survival after shock therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy-defibrillator recipients according to rhythm shocked. The ALTITUDE survival by rhythm study.
This study sought to determine if the risk of mortality associated with inappropriate implantable cardioverter-defibrillator (ICD) shocks is due to the underlying arrhythmia or the shock itself.</AbstractText>Shocks delivered from ICDs are associated with an increased risk of mortality. It is unknown if all patients wh...
12,902
Establishment and evaluation of a swine model of acute myocardial infarction and reperfusion-ventricular fibrillation-cardiac arrest using the interventional technique.
Ventricular fibrillation is the main cause of sudden cardiac death among patients with acute myocardial infarction (AMI). Substantial benefits could be obtained by both researchers and practitioners if an AMI reperfusion-ventricular fibrillation-cardiac arrest model were established.</AbstractText>Twenty swine were ane...
12,903
The pattern of Tpeak-Tend and QT interval, and J wave during therapeutic hypothermia.
The electrocardiogram manifestations of hypothermia include J waves and prolongation of QT intervals. This study described changes in repolarization patterns during therapeutic hypothermia (TH).</AbstractText>We measured the QTc and the interval from the peak to the end of the T wave (TpTe) from the V4 and V6 leads in ...
12,904
Percutaneous Assist Device for Cardiopulmonary Resuscitation.
Persistent cardiac arrest is often caused by coronary ischemia. Urgent revascularization during on-going resuscitation with the support of percutaneous left ventricular assist devices (PVAD) may be feasible and can have the potential to improve the prognosis. Transport during resuscitation is a challenge that may be ov...
12,905
Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan.
The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan.</AbstractText>The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF w...
12,906
Frequency of QTc prolongation in patients with hemorrhagic stroke.
Acute cerebral events play an important role in generating autonomic imbalance especially cardiac rhythm disturbances. This forms the basis of significant lethal abnormalities of heart rate and rhythm like QTc prolongation, ventricular fibrillation, asystole, and ultimately death. This study was conducted to determine ...
12,907
Rate Control in Atrial Fibrillation: Methods for Assessment, Targets for Ventricular Rate during AF, and Clinical Relevance for Device Therapy.
Rate control is a widely used treatment strategy for management of patients with atrial fibrillation (AF). Multiple studies have shown that pharmacologic rate control is as effective as pharmacologic rhythm control for management of AF. A snapshot ECG or intermittent monitoring using Holters is the most widely used tec...
12,908
[Coronary artery fistulas, a current problem: Clinical and therapeutic considerations].
The coronary fistula is a link between one or more of the coronary arteries and cardiac cavity or great vessel. The exact occurrence is unknown. The majority of these fistulas are congenital in origin. However, they may occasionally be detected after cardiac surgery. For a long time, fistulas are asymptomatic, especial...
12,909
Effect of Shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine.
Shenfu injection (SFI), a traditional Chinese formulation, has been confirmed to be protective against brain during ischemia and reperfusion injury. In this exploratory study, we investigated the action of SFI in regulating the inflammatory response and brain edema after cardiopulmonary resuscitation.</AbstractText>Aft...
12,910
High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine.
We investigated the metabolic and functional myocardial effects of erythropoietin (EPO) administered during resuscitation from cardiac arrest using an open-chest pig model of ventricular fibrillation and resuscitation by extracorporeal circulation, after having reported in rats a reversal of postresuscitation myocardia...
12,911
Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification.
Ryanodine receptor type 2 (RyR2) mutations are implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT) thought to result from altered myocyte Ca(2+) homeostasis reflecting inappropriate "leakiness" of RyR2-Ca(2+) release channels arising from increases in their basal activity, alterations in their ph...
12,912
Comparison of rosuvastatin versus atorvastatin for preventing postoperative atrial fibrillation.
Postoperative atrial fibrillation (AF) following cardiac surgery is associated with an increased risk of stroke, prolonged hospitalization, and increased costs. Statin therapy is associated with a lower incidence of postoperative AF. We aimed to compare the preventive effects of rosuvastatin and atorvastatin on postope...
12,913
An atypical temporal sequence for right heart endocarditis: case report.
In 2010, an 82-year-old patient received a diagnosis of stage IV chronic obstructive pulmonary disease, ischemic dilated cardiomyopathy, severe secondary pulmonary hypertension, atrial fibrillation with slow ventricular response, and severe tricuspid regurgitation. In December 2011, he was hospitalized for exacerbation...
12,914
[Early repolarisation. A dilemma of risk stratification].
Early repolarization, involving infero-lateral ST segment elevation and prominent J waves at the QRS-ST junction has been considered a normal ECG variant for more than 80 years. More recent studies suggest that this phenomenon is not as benign as earlier believed and may represent a risk for subsequent ventricular fibr...
12,915
Exchange transfusion for severe malaria: evidence base and literature review.
Exchange transfusion (ET) has biologic plausibility as an adjunct to antimalarial drugs in treating severe malaria and has been used for decades despite limited evidence of its efficacy in improving survival. We examined the efficacy of ET as an adjunct treatment for severe malaria using US surveillance data and review...
12,916
Prevalence of troponin elevations in patients with cardiac arrest and implications for assessing quality of care in hypothermia centers.
The prevalence of troponin elevations in patients with cardiac arrest (CA) using newer generation troponin assays when the ninety-ninth percentile is used has not been well described. We studied patients admitted with CA without ST elevation myocardial infarction (MI). Treatment included a multidisciplinary protocol th...
12,917
Operative techniques in association with arrhythmia surgery in patients with congenital heart disease.
Arrhythmia surgery in patients with congenital disease is challenged by the range of anatomic variants, arrhythmia types, and intramyocardial scar location. Experimental and clinical studies have elucidated the mechanisms of arrhythmias for accessory connections, atrial fibrillation, atrial reentry tachycardia, nodal r...
12,918
A heterozygous missense SCN5A mutation associated with early repolarization syndrome.
The genetic background of early repolarization syndrome (ERS) has not been fully understood. In this study, we identified a missense SCN5A mutation and a polymorphism in a patient with ERS and characterized the functional consequences of the two variants. The functional consequences of mutant channels were investigated...
12,919
Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations.
There is currently no reliable way of predicting the optimal implantable cardioverter-defibrillator (ICD) placement in paediatric and congenital heart defect (CHD) patients. This study aimed to: (1) develop a new image processing pipeline for constructing patient-specific heart-torso models from clinical magnetic reson...
12,920
[Implantable cardiac defibrillator (ICD): basics and present clinical guidelines].
An implantable cardiac defibrillator (ICD) is a cardiac implantable electronic device that is capable of identifying and treating ventricular arrhythmias. Consideration about the type of ICD to select for a given patient include whether the patient has bradycardia requiring pacing support, has associated atrial tachyar...
12,921
Donepezil-induced torsades de pointes without QT prolongation.
We report a case of torsades de pointes (TdP) induced by donepezil without QT prolongation. An 86-year-old woman was admitted to our hospital because of a syncopal attack. She had been treated for Alzheimer's disease with donepezil. Initial 12-lead electrocardiogram showed atrial fibrillation and normal corrected QT in...
12,922
The role of echocardiography in thromboembolic risk assessment of patients with nonvalvular atrial fibrillation.
Echocardiography is a widely used and versatile technique that can provide comprehensive information concerning thromboembolic risk in patients with atrial fibrillation. The authors review the potential contributions of echocardiography to thromboembolic risk stratification and to decreasing the thromboembolic risk ass...
12,923
Use of transthoracic impedance cardiography and tissue Doppler echocardiography in the cardiovascular assessment of atrial fibrillation patients subjected to electroversion.
Atrial fibrillation (AF) is the commonest complex cardiac arrhythmia, affecting approximately 2% of the general population.</AbstractText>To describe cardiovascular changes in tissue Doppler echocardiography (TDE) and impedance cardiography (ICG) in AF patients subjected to cardioversion.</AbstractText>Forty-one patien...
12,924
Prevalence and predisposing conditions for atrial fibrillation in hospitalised patients with hypertension.
Hypertension, due to its prevalence, is a common and independent risk factor for atrial fibrillation (AF). High blood pressure causes structural and functional changes in the myocardium, leading to an increased risk of arrhythmia. This risk is higher when hypertension is accompanied by concomitant diseases that contrib...
12,925
The right ventricle in patients with chronic heart failure and atrial fibrillation.
Under normal conditions function of the right ventricle (RV) is determined by the heart rhythm, RV filling time, RV systolic synchrony and interdependence between both ventricles. Failure of the left ventricle (LV) can lead to RV failure. Impaired function of the RV significantly worsens the prognosis in patients after...
12,926
QT variability during initial exposure to sotalol: experience based on a large electronic medical record.
A prolonged QT interval is associated with increased risk of Torsades de pointes (TdP) and may be fatal. We sought to investigate the extent to which clinical covariates affect the change in QT interval among 'real-world' patients treated with sotalol and followed in an electronic medical record (EMR) system.</Abstract...
12,927
High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial.
Andes virus (ANDV)-related hantavirus cardiopulmonary syndrome (HCPS) has a 35% case fatality rate in Chile and no specific treatment. In an immunomodulatory approach, we evaluated the efficacy of intravenous methylprednisolone for HCPS treatment, through a parallel-group, placebo-controlled clinical trial.</AbstractTe...
12,928
Unmasked superoparaseptal pathway conduction due to atrial fibrillation in a patient with left ventricular dysfunction. Rapid recovery after successful radiofrequency ablation.
We report the case of a 56-year-old woman with newly diagnosed atrial fibrillation (AF) and severe left ventricular (LV) dysfunction caused by rapid conduction via an accessory pathway (AP), mimicking left bundle branch block, as the first clinical manifestation of Wolff-Parkinson-White (WPW) syndrome. Electrical cardi...
12,929
Underdetection of ventricular fibrillation despite ICD testing and high sinus R wave.
Apart from monitoring shock efficacy, proof of flawless detection of induced ventricular fibrillation (VF) is a decisive argument in favor of implantable cardioverter defibrillator (ICD) testing. On the other hand, it has been observed that undersensing of VF is extremely rare with good sensing of the intrinsic R wave ...
12,930
Differences in catheter ablation of paroxysmal atrial fibrillation between males and females.
Catheter ablation (CA) has become a standard treatment for patients with atrial fibrillation (AF). However, gender-related differences associated with CA of paroxysmal AF (PAF) remain unclear.</AbstractText>We compared 1124 consecutive patients (mean age, 61 &#xb1; 10 years; male, n=864) with PAF scheduled for CA betwe...
12,931
Aborted sudden cardiac death in a child with left ventricular non-compaction.
Left ventricular non-compaction is a rare form of cardiomyopathy believed to be the result of intrauterine arrest of compaction of the endomyocardial morphogenesis, leading to persistence of the embryonic myocardium. Clinical manifestations are highly variable, ranging from no symptoms to a progressive deterioration in...
12,932
Increased P-wave dispersion in patients with newly diagnosed lichen planus.<Pagination><StartPage>846</StartPage><EndPage>850</EndPage><MedlinePgn>846-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.6061/clinics/2013(06)20</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTI...
Background:&#x2002;Renal dysfunction is associated with a higher rate of atrial fibrillation in clinical practice. This study investigated the associations between renal function, left ventricular (LV) diastolic dysfunction, and postoperative atrial fibrillation (POAF). Methods and Results:&#x2002;A total of 265 consec...
12,933
The power of exercise-induced T-wave alternans to predict ventricular arrhythmias in patients with implanted cardiac defibrillator.
The power of exercise-induced T-wave alternans (TWA) to predict the occurrence of ventricular arrhythmias was evaluated in 67 patients with an implanted cardiac defibrillator (ICD). During the 4-year follow-up, electrocardiographic (ECG) tracings were recorded in a bicycle ergometer test with increasing workload rangin...
12,934
Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass in piglets.
Surgery under cardiopulmonary bypass (CPB) is still associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully understood. Abnormalities in coronary flow and function have been suggested to play an important role. Prior studies suggest protective effects o...
12,935
The dronedarone shared-care clinical model and database: a coordinated paradigm to optimize management of evolving clinical recommendations.
Dronedarone, a non-iodinated derivative of amiodarone, has been approved for use as a second-line agent for atrial fibrillation (AF). Following reports of possible liver injury during routine post-license monitoring, the European Medicines Agency (EMA) recommended regular liver function test (LFT) monitoring. Despite t...
12,936
A surgical experience of symptomatic sigmoid septum: drastic exacerbation of mitral regurgitation after sufficient ventricular septal myectomy.
A 74-year-old woman presented with progressive dyspnea on exertion. Transthoracic echocardiography (TTE) demonstrated significant left ventricular outflow tract (LVOT) obstruction with a pressure gradient of 100 mmHg caused by a sigmoid septum (SS). Mitral regurgitation (MR) of a mild to moderate degree occurred due to...
12,937
Heart failure exacerbation associated with newly developed atrioventricular dyssynchrony after chemical conversion to a sinus rhythm in a patient receiving cardiac resynchronization therapy.
A 58-year-old woman with chronic heart failure (CHF) received cardiac resynchronization-defibrillator (CRT-D) therapy without atrial lead implantation due to longstanding atrial fibrillation (AF). Three months after oral amiodarone therapy was initiated for the treatment of non-sustained ventricular tachycardia detecte...
12,938
Minimally invasive fibrillating heart surgery: a safe and effective approach for mitral valve and surgical ablation for atrial fibrillation.
Minimally invasive (MI) approaches to mitral valve surgery (MVS) and surgical ablation for atrial fibrillation (AF) are now performed routinely, and avoidance of aortic manipulation and cardioplegic arrest may further simplify the procedure. We present our experience with MI fibrillatory cardiac operations without aort...
12,939
Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction.
Large animal models serve as a critical link in the translation of basic science to clinical practice. However, large animal models of myocardial infarction (MI), especially large size MI, have been associated with high mortality because of arrhythmia. The prophylactic effect of amiodarone and lidocaine were retrospect...
12,940
Visual data mining with self-organising maps for ventricular fibrillation analysis.
Detection of ventricular fibrillation (VF) at an early stage is being deeply studied in order to lower the risk of sudden death and allows the specialist to have greater reaction time to give the patient a good recovering therapy. Some works are focusing on detecting VF based on numerical analysis of time-frequency dis...
12,941
Predictors of long-term outcomes in symptomatic hypertrophic obstructive cardiomyopathy patients undergoing surgical relief of left ventricular outflow tract obstruction.
We report the predictors of long-term outcomes of symptomatic hypertrophic cardiomyopathy patients undergoing surgical relief of left ventricular outflow tract obstruction.</AbstractText>We studied 699 consecutive patients who have hypertrophic cardiomyopathy with severe symptomatic left ventricular outflow tract obstr...
12,942
Acute exposure to air pollution triggers atrial fibrillation.
This study sought to evaluate the association of air pollution with the onset of atrial fibrillation (AF).</AbstractText>Air pollution in general and more specifically particulate matter has been associated with cardiovascular events. Although ventricular arrhythmias are traditionally thought to convey the increased ca...
12,943
What do we know about the "malignant form" of early repolarization?
There is an urgent need to identify electrocardiographic characteristics that differentiate the "benign early repolarization pattern" from "malignant early repolarization." In a previous paper, we considered the different electrocardiographic elements of the early repolarization pattern and analyzed how they confer imp...
12,944
Myocardial infarct heterogeneity assessment by late gadolinium enhancement cardiovascular magnetic resonance imaging shows predictive value for ventricular arrhythmia development after acute myocardial infarction.
The aim of this study was to assess the association between the proportions of penumbra-visualized by late gadolinium enhanced cardiovascular magnetic resonance imaging (LGE-CMR)-after acute myocardial infarction (AMI) and the prevalence of ventricular tachycardia (VT).</AbstractText>One-hundred and sixty-two AMI patie...
12,945
Heart rate variability risk score for prediction of acute cardiac complications in ED patients with chest pain.
We aimed to develop a risk score incorporating heart rate variability (HRV) and traditional vital signs for the prediction of early mortality and complications in patients during the initial presentation to the emergency department (ED) with chest pain.</AbstractText>We conducted a prospective observational study of pa...
12,946
Utility of mapping signals to improve precision of atrioventricular node ablation.
Atrioventricular node (AVN) ablation is effective for rate control in atrial fibrillation. This may require multiple radiofrequency applications to achieve complete atrioventricular block (CAB). In this retrospective study, we tested the hypothesis that mapping the AVN utilizing electrograms (EGMs) on both proximal and...
12,947
[Anticoagulation in atrial fibrillation: new therapeutic alternatives].
The fundamental treatment of atrial fibrillation is based on maintenance of sinus rhythm or control of ventricular rate and preventing arterial thromboembolism. Warfarin has been the anti-thrombotic agent of choice for the last 50 years. However multiple interactions with other drugs and certain types of food and veget...
12,948
Focal left atrial tachycardia in a patient with left ventricular noncompaction.
Left ventricular noncompaction (LVNC) is a rare disease caused by intrauterine failure of the myocardium to compact. The major clinical manifestations of LVNC include heart failure, ventricular tachyarrhythmia, thromboembolic event, and sudden deaths. Atrial arrhythmia usually seen is atrial fibrillation. We report a r...
12,949
Crack cocaine-induced cardiac conduction abnormalities are reversed by sodium bicarbonate infusion.
We report a dramatic case of a 19-year-old man with crack cocaine overdose with important clinical complications as cardiac arrest due to ventricular fibrillation and epileptics status. During this intoxication, electrocardiographic abnormalities similar to those found in tricyclic antidepressant poisoning were observe...
12,950
Transthoracic epicardial catheter ablation: indications, techniques, and complications.
Transthoracic epicardial catheter ablation is a useful supplemental or even preferred strategy to eliminate cardiac arrhythmias in the electrophysiology laboratory. The indication for this technique has extended to a diverse range of cardiac arrhythmias, including scar-related ventricular tachycardia (VT), idiopathic V...
12,951
Characteristics and outcomes of patients receiving new and replacement implantable cardioverter-defibrillators: results from the NCDR.
Little is known about the clinical features, procedural risks, or survival of patients receiving replacement versus new implantable cardioverter-defibrillators (ICDs).</AbstractText>Entries in the National Cardiovascular Data Registry (NCDR) ICD Registry from 2005 through 2010 were eligible for inclusion (n=463,978). B...
12,952
Renal sympathetic denervation versus antiarrhythmic drugs for drug-resistant hypertension and symptomatic atrial fibrillation (RSDforAF) trial: study protocol for a randomized controlled trial.
Recently, catheter-based renal sympathetic denervation (RSD) has been verified to be safely used to substantially reduce the levels of blood pressure, left ventricular hypertrophy, sleep apnea severity and norepinephrine spillover, and improve glucose tolerance. All these pathological changes are recognized as independ...
12,953
Disease management: atrial fibrillation and home monitoring.
Device-detected atrial fibrillation (AF) episodes predict poor clinical outcome regardless of symptoms. Potential benefits of remote monitoring are early arrhythmia detection and patient continuous monitoring. Several studies of device remote monitoring consistently demonstrated that AF represents the most common clini...
12,954
Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias.
The autonomic nervous system (ANS) has a pivotal role in the pathogenesis and maintenance of atrial and ventricular arrhythmias. Catheter-based renal denervation (RDN) is associated with a reduction of central sympathetic activity, muscle sympathetic nerve activity, and blood pressure in resistant hypertension. As rena...
12,955
Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study.
We aimed to investigate the association of number of completed races and finishing time with risk of arrhythmias among participants of Vasaloppet, a 90 km cross-country skiing event.</AbstractText>All the participants without cardiovascular disease who completed Vasaloppet during 1989-98 were followed through national ...
12,956
[Implementation of the therapeutic hypothermia recommendation after resuscitated cardiac arrest caused by ventricular fibrillation and tachycardia without pulse: a retrospective study in Saint-Pierre Hospital].
Therapeutic hypothermia is an essential step for the neurological protection of comatose individuals after cardiorespiratory arrest (CA) and ventricular fibrillation (VF). The evaluation of the application of the Protocol thereto within the C.H.U. Saint-Pierre (SPH) is the subject of this study.</AbstractText>Retrospec...
12,957
Increased risk of sudden cardiac arrest in obstructive pulmonary disease: a case-control study.
We aimed to determine whether (1) patients with obstructive pulmonary disease (OPD) have an increased risk of sudden cardiac arrest (SCA) due to ventricular tachycardia or fibrillation (VT/VF), and (2) the SCA risk is mediated by cardiovascular risk-profile and/or respiratory drug use.</AbstractText>A community-based c...
12,958
A case of riata&#xae; dual coil defibrillator lead failure in a patient with ventricular fibrillation.
A 50-year-old man, who underwent a procedure for an implantable cardioverter defibrillator (ICD), visited the outpatient department of our clinic after suffering multiple ICD shocks. The ICD interrogation revealed recurrent shock due to a high frequency of noise that is sensed by the device as ventricular fibrillation....
12,959
Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study.
A higher risk of cardiovascular events has been reported in patients with primary aldosteronism (PA) than in otherwise similar patients with essential hypertension (EH). However, the evidence is limited by small sample size and potential confounding factors. We, therefore, compared the prevalence of cardiovascular even...
12,960
Intensive care management following defibrillation of an adolescent girl after recreational inhalant use: a case report and review of the literature.
We report the successful out-of-hospital defibrillation and intensive care management of a 14-year-old girl who developed ventricular fibrillation following the inhalation of two 150-mL butane cigarette lighter refill canisters. Following ambulance transport to the nearest tertiary pediatric health care facility, her a...
12,961
Implementation of mechanical chest compression in out-of-hospital cardiac arrest in an emergency medical service system.
The aim of this study is to describe the outcome changes after out-of-hospital cardiac arrest (OHCA) in Gothenburg, Sweden, after introduction of mechanical chest compression (MCC).</AbstractText>Following introduction of MCC, 1183 OHCA patients were treated from November 1, 2007, to December 31, 2011 (period 2). They ...
12,962
Cardiopulmonary resuscitation: outcome and its predictors among hospitalized elderly patients in Egypt.
Our aim was to study the outcome and the predictors of in-hospital cardiopulmonary resuscitation (CPR) among elderly patients admitted to Ain Shams University Hospitals, Egypt.</AbstractText>We carried out a cross-sectional study for all elderly patients (age &#x2265;60 years) who underwent CPR after cardiac arrest at ...
12,963
Syncope caused by coronary artery spasm without chest pain leading to ventricular fibrillation.
We present a case of syncope caused by coronary artery spasm without chest pain leading to ventricular fibrillation despite of vasodilator therapy with a calcium channel blocker (CCB). A 68-year-old man presented with two episodes of syncope without chest pain. Ergonovine provocation test induced a diffuse spasm in the...
12,964
Infant ventricular fibrillation after ST-segment changes and QRS widening: a new cause of sudden infant death?
Ventricular arrhythmia-related sudden cardiac arrest in infants with structurally normal hearts is rare. There have been no previously published reports of infants &lt;3 months of age with ventricular fibrillation in which a primary diagnosis could not be defined.</AbstractText>Retrospective chart review of 3 unrelated...
12,965
Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization.
This study sought to characterize patients with idiopathic ventricular fibrillation (IVF) who develop electrical storms.</AbstractText>Some IVF patients develop ventricular fibrillation (VF) storms, but the characteristics of these patients are poorly known.</AbstractText>Ninety-one IVF patients (86% male) were selecte...
12,966
Lone atrial fibrillation as a positive predictor of left atrial volume reduction following ablation of atrial fibrillation.
We investigated predictors of left atrial volume reduction (LAVR) in patients with atrial fibrillation (AF) undergoing AF ablation.</AbstractText>Sixty patients with AF underwent pulmonary vein isolation (PVI) using a pulmonary vein ablation catheter (PVAC). All patients underwent cardiac imaging by computed tomography...
12,967
Clinical predictors and hemodynamic consequences of elevated peripheral chemosensitivity in optimally treated men with chronic systolic heart failure.
Augmented peripheral chemoreflex response is an important mechanism in the pathophysiology of chronic heart failure (CHF). This study characterizes prevalence and clinical predictors of this phenomenon in optimally managed male CHF patients, and seeks to describe the hemodynamic consequences of chemoreceptor hypersensi...
12,968
Prophylactic lidocaine for post resuscitation care of patients with out-of-hospital ventricular fibrillation cardiac arrest.
Antiarrhythmic drugs like lidocaine are usually given to promote return of spontaneous circulation (ROSC) during ongoing out-of-hospital cardiac arrest (OHCA) from ventricular fibrillation/tachycardia (VF/VT). Whether administering such drugs prophylactically for post-resuscitation care after ROSC prevents re-arrest an...
12,969
The ECG in cardiovascular-relevant animal models of electrophysiology.
The most frequently used animal species in experimental cardiac electrophysiology are mice, rabbits, and dogs. Murine and human electrocardiograms (ECGs) show salient differences, including the occurrence of a pronounced J-wave and a less distinctive T-wave in the murine ECG. Mouse models can resemble human cardiac arr...
12,970
On pump versus off pump coronary artery bypass surgery in patients over seventy years old with triple vessels disease and severe left ventricle dysfunction: focus on early clinical outcomes.
Cardiovascular disease is the leading reason of morbidity in older people. Coronary artery bypass graft (CABG) surgery is the most common type of operations in world. This study was designed to characterize comparison of early clinical outcome following on pump vs. off pump in patients over 70 years old with triple ves...
12,971
Time-dependent effect of cardiac resynchronization therapy on ventricular repolarization and ventricular arrhythmias.
Cardiac resynchronization therapy (CRT) improves the clinical status of patients with congestive heart failure, although left ventricular epicardial pacing may increase transmural dispersion of repolarization (TDR). The aim of this study was to investigate the time-dependent effect of CRT on ventricular repolarization ...
12,972
Electrical features of eighteen automated external defibrillators: a systematic evaluation.
Assessment and comparison of the electrical parameters (energy, current, first and second phase waveform duration) among eighteen AEDs.</AbstractText>Engineering bench tests for a descriptive systematic evaluation in commercially available AEDs. AEDs were tested through an ECG simulator, an impedance simulator, an osci...
12,973
Use of impedance threshold device in conjunction with our novel adhesive glove device for ACD-CPR does not result in additional chest decompression.
To evaluate the hemodynamic effects of using an adhesive glove device (AGD) to perform active compression-decompression CPR (AGD-CPR) in conjunction with an impedance threshold device (ITD) in a pediatric cardiac arrest model.</AbstractText>Controlled, randomized animal study.</AbstractText>In this study, 18 piglets we...
12,974
The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: a critical reassessment.
Although epidemiological studies provide strong evidence for an inverse relationship between omega-3 polyunsaturated fatty acids (n-3 PUFAs) and cardiac mortality, inconsistent and often conflicting results have been obtained from both animal studies and clinical prevention trials. Despite these heterogeneous results, ...
12,975
An unusual but reversible cause of ventricular fibrillation.
A 61-year-old woman was admitted with general malaise, chest pain and breathlessness. During her inpatient stay she sustained a ventricular fibrillation (VF) arrest which was successfully terminated with direct current cardioversion. Cardiac investigations revealed poor left ventricular systolic function but unequivoca...
12,976
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Transient receptor potential (TRP) channels are a superfamily of broadly expressed ion channels with diverse physiological roles. TRPC1, TRPC3, and TRPC6 are believed to contribute to cardiac hypertrophy in mouse models. Human mutations in TRPM4 have been linked to progressive familial heart block. TRPM7 is a divalent-...
12,977
Relationship between P wave dispersion, left ventricular mass index and blood pressure.
The study of arterial hypertension risk factors in children guarantees the establishment of health policies to avoid complications associated with this illness in the future. The highest values of P-wave dispersion during sinus rhythm are pointed as predictors of atrial fibrillation in adulthood since there is an assoc...
12,978
Stem-cell therapy for dilated cardiomyopathy: a pilot study evaluating retrograde coronary venous delivery.
To evaluate retrograde coronary venous stem-cell delivery for Dobermanns with dilated cardiomyopathy.</AbstractText>Retrograde coronary venous delivery of adipose-derived mesenchymal stem cells transduced with tyrosine mutant adeno-associated virus 2 to express stromal-derived factor-1 was performed in Dobermanns with ...
12,979
TUGENDHAT: a pilot randomized study on effects of biventricular pacing in patients with bradycardia pacing indication and normal systolic function on heart failure, atrial fibrillation and quality of life (results of 12 month follow-up).
Since the late 1990s, a growing number of clinical studies have indicated that long-term permanent right ventricular (RV) apical pacing will induce severe complications such as development of heart failure, increased burden of atrial fibrillation leading to decreased quality of life.</AbstractText>To investigate whethe...
12,980
Risk stratification for implantable cardioverter defibrillator therapy: the role of the wearable cardioverter-defibrillator.
The benefit of implantable cardioverter-defibrillator (ICD) therapy depends upon appropriate evaluation of a persisting risk of sudden death and estimation of the patient's overall survival. Assessment of a stable and unchangeable arrhythmogenic substrate is often difficult. Structural abnormality and ventricular dysfu...
12,981
Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy: preliminary results.
Several factors can influence the extent of left ventricular (LV) reverse remodelling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF). Polymorphism in genes involved in cardiac remodelling, namely beta-adrenergic receptors (ARs), may have a role. We studied the influence of beta-1 Arg3...
12,982
Left cardiac sympathetic denervation in long QT syndrome: analysis of therapeutic nonresponders.
Long QT syndrome (LQTS) is a potentially lethal but highly treatable cardiac channelopathy. Treatment options include pharmacotherapy, device therapy, and left cardiac sympathetic denervation (LCSD). Here, we sought to determine the characteristics of LQTS patients who have had &#x2265;1 LQTS-related breakthrough cardi...
12,983
Validation of novel 3-dimensional electrocardiographic mapping of atrial tachycardias by invasive mapping and ablation: a multicenter study.
This study prospectively evaluated the role of a novel 3-dimensional, noninvasive, beat-by-beat mapping system, Electrocardiographic Mapping (ECM), in facilitating the diagnosis of atrial tachycardias (AT).</AbstractText>Conventional 12-lead electrocardiogram, a widely used noninvasive tool in clinical arrhythmia pract...
12,984
Effect of reduced sympathetic hyperactivity on cardiovascular risk factors in kidney transplantation patients.
Hyperactivity of the sympathetic nervous system caused by chronic kidney disease has detrimental effects on hypertension and cardiovascular morbidity. Kidney transplantation does not ameliorate sympathetic nerve overactivity; however, bilateral nephrectomy eliminates it. The aim of the study was to evaluate the effect ...
12,985
Efficacy of the CHADS&#x2082; scoring system to assess left atrial thrombogenic milieu risk before cardioversion of non-valvular atrial fibrillation.
The CHADS&#x2082; scoring system was found to be a good predictor for risk stratification of stroke in patients with atrial fibrillation. The effectiveness of this scoring system in assessing thrombogenic milieu before direct-current cardioversion has not yet fully been established on a large scale. In this study, data...
12,986
Prevalence and predictors of worsened left ventricular diastolic dysfunction after catheter ablation of atrial fibrillation.
The interactions between atrial fibrillation (AF) and left ventricular diastolic dysfunction (LVDD) are complex and not well defined. Despite the high prevalence of LVDD in the AF population, therapies for LVDD remain limited. Previous studies have suggested that restoration of sinus rhythm with catheter ablation has a...
12,987
Sudden Cardiac Death in a Case of Non-Dominant Coronary Artery Obstruction Without Depressed Left Ventricular Function.
Acute myocardial infarction complicated with lethal cardiac arrhythmia remains the major cause of sudden death. The possible clinical presentation leading to lethal ventricular arrhythmia has been demonstrated but the data are limited. The previous study revealed no significant correlation between sudden cardiac death ...
12,988
Current and emerging antiarrhythmic drug therapy for ventricular tachycardia.
Ventricular arrhythmias, including ventricular fibrillation (VF) and sustained ventricular tachycardia (VT), are the principal causes of sudden cardiac death in patients with structural heart disease. While coronary artery disease is the predominant substrate associated with the development of VT, these arrhythmias are...
12,989
Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.
Recent studies reported slowed conduction velocity (CV) in murine hearts homozygous for the gain-of-function RyR2-P2328S mutation (RyR2(S/S)) and associated this with an increased incidence of atrial and ventricular arrhythmias. The present experiments determined mechanisms contributing to the reduced atrial CV.</Abstr...
12,990
Drowning, hypothermia and cardiac arrest: an 18-year-old woman with an automated external defibrillator recording.
This report describes the case of an 18-year-old woman who was found in the sea suffering from cardiac arrest and hypothermia, 90 minutes after she entered the water to swim. The rescue team used an automated external defibrillator to record prehospital management. This recording showed an isoelectric electrocardiogram...
12,991
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Hypertension-induced myocardial remodeling is known to be associated with increased risk for malignant arrhythmias and alterations in electrical coupling protein, connexin-43 (Cx43), may be involved. We investigated whether omega-3 fatty acids intake affects abnormalities of Cx43 as well as protein kinase C (PKC) signa...
12,992
A flexible approach for simulating physiological signals.
Generating synthetic physiological signals using information extracted from real world physiological signals plays an important role in the field of medical device development and education. Most of the existing approaches are limited in the sense that they either focus on a particular physiological signal or lack flex...
12,993
[Characteristic cardiac rhythm disturbances in patients with chronic obstructive pulmonary disease].
This 24 hr ECG monitoring study included 226 patients with isolated chronic obstructive pulmonary disease, arterial hypertension and coronary heart disease. It revealed severe cardiac rhythm disturbances with the prevalence of high-grade ventricular extrasystole (66.6%), andfrequent paired and grouped supraventricular ...
12,994
A caval homograft for Budd-Chiari syndrome due to inferior vena cava obstruction.
Transjugular intrahepatic portosystemic shunt (TIPS) is the standard treatment of Budd-Chiari syndrome (BCS) non responsive to medical therapy. However, patients with inferior vena cava (IVC) obstruction proximal to the atrium do not benefit from TIPS and a surgical approach is mandatory. We report the case of BCS due ...
12,995
SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.
A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrilla...
12,996
Forgotten electrical accidents and the birth of shockproof X-ray systems.
To commemorate victims of electrical accidents that occurred in the first decades of radiology and relate these accidents to the evolution of the X-ray apparatus.</AbstractText>Digitised newspapers, scientific journals, books and reports of legal procedures were searched for electrical accidents involving X-ray systems...
12,997
The direct factor Xa inhibitor Rivaroxaban reduces platelet activation in congestive heart failure.
Platelet activation in congestive heart failure (CHF) contributes to an increased risk for thromboembolic complications. Rivaroxaban, the first oral direct FXa inhibitor is approved in Europe for prevention and treatment of venous thrombosis, pulmonary embolism, and prevention of thromboembolic events in atrial fibrill...
12,998
Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials.
Omega-3 polyunsaturated fatty acids (PUFA) have demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results.</AbstractText>We aimed to analyze the effect of omega-3 PUFA on preventing potentially fatal ventricular arrhythmias and sudden cardiac death.</AbstractText>Random...
12,999
Quantitative electrocardiographic measures, neuromuscular disorders, and survival in left ventricular hypertrabeculation/noncompaction.
Left ventricular hypertrabeculation/noncompaction (LVHT) is frequently associated with neuromuscular disorders (NMDs) and electrocardiographic (ECG) abnormalities. Quantitative ECG-measures (QEMs) are risk markers for mortality in cardiomyopathies. We measured QEMs in the ECGs in LVHT patients with and without NMDs.</A...