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13,300 | Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy. | Reduced echocardiographic strain is associated with ventricular arrhythmias in hypertrophic cardiomyopathy (HCM) patients. The aim of this cross-sectional study was to investigate which type of histological fibrosis contributes to ventricular arrhythmias and reduced septal longitudinal strain, in obstructive HCM-patien... |
13,301 | Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias. | Animal and clinical studies have demonstrated that oxidative stress, a common pathophysiological factor in cardiac disease, reduces repolarization reserve by enhancing the L-type calcium current, the late Na, and the Na-Ca exchanger, promoting early afterdepolarizations (EADs) that can initiate ventricular tachycardia ... |
13,302 | Obesity, brain natriuretic peptide levels and mortality in patients hospitalized with heart failure and preserved left ventricular systolic function. | An inverse relationship between brain natriuretic peptide (BNP) levels and body mass index (BMI) has been described for patients with left ventricular (LV) systolic dysfunction. In this study, the association of BMI, BNP levels and mortality in patients hospitalized for heart failure with preserved LV systolic function... |
13,303 | Shen-Fu injection reduces impaired myocardial β-adrenergic receptor signaling after cardiopulmonary resuscitation. | Post-resuscitation myocardial dysfunction has been implicated as a major cause of fatal outcome in patients who survive initially successful cardiopulmonary resuscitation (CPR). In our previous study, we found that impaired myocardial β-adrenergic receptor (AR) signaling is a key mechanism in post-resuscitation m... |
13,304 | Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery before hypothermic cardioplegia. | Simultaneous inhibition of the cardiac equilibrative-p-nitrobenzylthioinosine (NBMPR)-sensitive (es) type of the equilibrative nucleoside transport 1 (ENT1) nucleoside transporter, with NBMPR, and adenosine deaminase, with erythro-9-[2-hydroxy-3-nonyl]adenine (EHNA), prevents release of myocardial purines and attenuate... |
13,305 | Adjunctive renal sympathetic denervation to modify hypertension as upstream therapy in the treatment of atrial fibrillation (H-FIB) study: clinical background and study design. | Hypertension is the most important risk factor directly attributable to the high prevalence of atrial fibrillation (AF), and is one of the few modifiable risk factors for AF. Activation and overactivity of the sympathetic nervous system (SNS) have been implicated in the pathogenesis of both essential hypertension and A... |
13,306 | Functional characterization of atrial electrograms in a pacing-induced heart failure model of atrial fibrillation: importance of regional atrial connexin40 remodeling. | Heart failure (HF) increases the susceptibility to atrial fibrillation (AF) and is associated with altered cardiomyocyte connexin. The regional remodeling of connexin(s) may contribute to the spatiotemporal organization of AF. This study sought to investigate the regional differences in connexin(s) and fibrosis in spec... |
13,307 | Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles. | Apamin-sensitive K currents (I(KAS)) are upregulated in heart failure. We hypothesize that apamin can flatten action potential duration restitution (APDR) curve and can reduce ventricular fibrillation duration in failing ventricles.</AbstractText>We simultaneously mapped membrane potential and intracellular Ca (Ca(i)) ... |
13,308 | Patient perceptions, physician communication, and the implantable cardioverter-defibrillator. | Implantable cardioverter-defibrillators (ICDs) have changed the way in which patients with chronic ventricular dysfunction are evaluated and treated.</AbstractText>To examine patient-physician communication at the time the decision is made to implant an ICD.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTI... |
13,309 | Cycle length characteristics differentiating non-sustained from self-terminating ventricular fibrillation in Brugada syndrome. | Limited information is available on self-terminating (ST) ventricular fibrillation (VF). Understanding spontaneous fluctuations in VF cycle length (CL) is required to identify arrhythmia that will stop before shock. Using Brugada syndrome (BS) as a model, the purpose of the study was to compare ST-VF and VF terminated ... |
13,310 | First responder for in-hospital resuscitation: 5-year experience with an automated external defibrillator-based program. | The survival of in-hospital cardiac arrest (8-25%) has not changed substantially in the past. Until now, most hospitals in Germany had no standardized protocols available for a course of action in case of emergency, and there are no continuous registry data for in-hospital cardiac arrest and survival.</AbstractText>Our... |
13,311 | Usefulness of scintigraphy to predict electrical storms in severe idiopathic dilated cardiomyopathy. | Although several predictors of an electrical storm (ES) are indicated in patients with idiopathic dilated cardiomyopathy (IDCM), whether the severity of the myocardial tissue damage (SMTD) evaluated by myocardial perfusion SPECT (MPS) has an association with an ES remains unclear. The purpose of this study was to eluci... |
13,312 | Left atrial size and function as predictors of new-onset of atrial fibrillation in patients with asymptomatic aortic stenosis: the simvastatin and ezetimibe in aortic stenosis study. | Left atrial (LA) size and function change with chronically increased left ventricular (LV) filling pressures. It remains unclear whether these variations in LA parameters can predict new-onset atrial fibrillation (AF) in asymptomatic patients with aortic stenosis (AS).</AbstractText>Data were obtained in asymptomatic p... |
13,313 | Sleep disordered breathing as a risk of cardiac events in subjects with diabetes mellitus and normal exercise echocardiographic findings. | Sleep disordered breathing (SDB) is associated with type 2 diabetes mellitus (T2DM) and cardiovascular disease; however, the contribution of SDB to incident heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF) in patients with T2DM is unknown. We followed up 834 consecutive asymptomatic patie... |
13,314 | Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo. | Atrial fibrillation (AF) is characterized by electrical and structural remodeling of the atria with atrial fibrosis being one hallmark. Angiotensin II (AngII) is a major contributing factor and blockage of its type I receptor (AT1R) prevents remodeling to some extent. Here we explored the effects of the AT1R antagonist... |
13,315 | Chloroquine cardiotoxicity mimicking connective tissue disease heart involvement. | The authors report a case of rare chloroquine cardiotoxicity mimicking connective tissue disease heart involvement in a 56-year-old woman with mixed connective tissue disease (MCTD) manifested suddenly as third degree A-V block with QT(c) interval prolongation and short torsade de pointes runs ultimately degenerating i... |
13,316 | Hybrid Melody pulmonary valve replacement in an adult with severe pulmonary hypertension and pulmonary artery aneurysm. | A 48-year-old female with D-TGA, ventricular septal defect (VSD), pulmonary stenosis, pulmonary hypertension (PAH), and total anomalous pulmonary venous connection underwent hybrid intervention for a pulmonary artery (PA) aneurysm and replacement of a dysfunctional pulmonary valve (PV). She underwent a hemi-Mustard pro... |
13,317 | Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study. | It is unknown whether atrial fibrillation (AF) is associated with an increased risk of sudden cardiac death (SCD) in the general population. This association was examined in 2 population-based cohorts.</AbstractText>In the Atherosclerosis Risk in Communities (ARIC) Study, we analyzed data from 15 439 participants (base... |
13,318 | Relationship of sudden cardiac death to new-onset atrial fibrillation in hypertensive patients with left ventricular hypertrophy. | Prevalent atrial fibrillation (AF) is associated with a higher sudden cardiac death (SCD) rate in some populations, and incident AF predicts increased mortality risk in the general population and after myocardial infarction. However, the relationship of SCD to new-onset AF is unclear.</AbstractText>The relationship of ... |
13,319 | Selective heart rate reduction with ivabradine slows ischaemia-induced electrophysiological changes and reduces ischaemia-reperfusion-induced ventricular arrhythmias. | Heart rates during ischaemia and reperfusion are possible determinants of reperfusion arrhythmias. We used ivabradine, a selective If current inhibitor, to assess the effects of heart rate reduction (HRR) during ischaemia-reperfusion on reperfusion ventricular arrhythmias and assessed potential anti-arrhythmic mechanis... |
13,320 | Perioperative management difficulties in parathyroidectomy for primary versus secondary and tertiary hyperparathyroidism. | In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anaesthetic management differs function of etiology (primary vs. secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).</AbstractText>To evaluate peri-operative management ... |
13,321 | Extreme but not life-threatening QT interval prolongation? Take a closer look at the neck! | We present the case of a 82-year-old woman with a history of total thyroidectomy who was admitted in hospital with severe hypocalcemia. A 12-lead surface ECG revealed atrial fibrillation along with an extremely prolonged QT interval of approximately 730ms. In the absence of any other possible cause of QT interval prolo... |
13,322 | A new antiarrhythmic drug in the treatment of recent-onset atrial fibrillation: vernakalant. | Vernakalant is a new antiarrhythmic agent recently approved in Europe for the rapid cardioversion of recent-onset atrial fibrillation. It works by blocking early-activating K+ atrial channels and frequency-dependent atrial Na+ channels, prolonging atrial refractory periods and rate-dependent slowing atrial conduction, ... |
13,323 | Early repolarization pattern associated with sudden cardiac death: long-term follow-up in patients with chronic heart failure. | Identification of patients with chronic heart failure (CHF) at a risk for sudden cardiac death (SCD) is an important objective. Early repolarization pattern (ERP) is associated with ventricular fibrillation in patients without structural heart diseases. Moreover, ERP was reported to be associated with SCD in patients w... |
13,324 | Atrial Fibrillation in Patients with Cardiac Resynchronization Therapy: Clinical Management and Outcome. | Atrial fibrillation (AF) and heart failure (HF) are two emerging epidemics in the cardiovascular field and are strictly inter-related since may directly predispose to each other. Cardiac resynchronization therapy (CRT) has emerged as an important therapeutic option for selected HF patients with LV dysfunction and ventr... |
13,325 | Prophylactic Antiarrhythmic Drug Therapy in Atrial Fibrillation. | In patients with recurrent atrial fibrillation (AF), the hallmark of treatment has been the use of antiarrhythmic drugs (AADs). Goals of therapy include reduction in the frequency and duration of episodes of arrhythmia as well an emerging goal of reducing mortality and hospitalizations associated with AF. Safety and ef... |
13,326 | Atrial Fibrillation in Patients with Ischemic and Non-Ischemic Left Ventricular Dysfunction. | Atrial fibrillation (AF) and left ventricular dysfunction (LVD) are increasingly common clinical problems, affecting millions of people worldwide. It is well established that the presence of AF portends a poor prognosis in the setting of both ischemic and non-ischemic LVD, and frequently results in worsening clinical s... |
13,327 | Amiodarone Induced Thyrotoxicosis - Fluctuating RVOT and LV Scar VT. | A 61 year old patient with non-ischemic cardiomyopathy and implantable cardioverter defibrillator presented with multiple shocks for ventricular tachycardia (VT). EKG revealed monomorphic sustained VT which was left bundle inferior axis that spontaneously changed into sustained VT which was right bundle superior axis. ... |
13,328 | Survival of a highly toxic dose of caffeine. | A 27-year-old woman with a history of depression and previous overdose presented within 60 min of ingestion of 50 g of caffeine powder. Initially alert but hypotensive and tachycardic, the patient developed a broad complex tachycardia followed by a seizure and multiple ventricular fibrillation (VF) arrests. Following m... |
13,329 | Electrophysiological and mechanical effects of caffeic acid phenethyl ester, a novel cardioprotective agent with antiarrhythmic activity, in guinea-pig heart. | Caffeic acid phenethyl ester (CAPE) is an active component of propolis that exhibits cardioprotective and antiarrhythmic effects. The detailed mechanisms underlying these effects, however, are not entirely understood. The aim of this study was to elucidate the electromechanical effects of CAPE in guinea-pig cardiac pre... |
13,330 | Selective left ventricular sensing lead implantation to overcome undersensing of ventricular fibrillation during implantable cardioverter defibrillator implantation. | Accurate sensing of malignant arrhythmia is critical for the appropriate delivery of therapy from implantable cardioverter defibrillators, and undersensing of ventricular tachyarrhythmias can have catastrophic consequences. Here, we present an unusual case of ventricular fibrillation undersensing from the right ventric... |
13,331 | Anterior crackles: a neglected sign? | We report on a man, aged 83 years, with chronic heart failure, atrial fibrillation, right ventricular pacing, and worsening exertional dyspnea who was referred for cardiac resynchronization therapy. Detection by anterior chest auscultation of pulmonary crackles during comfortable supine breathing in the context of docu... |
13,332 | [Peculiarities of myocardial remodeling in the acutest phase of experimental myocardial infarction in rats]. | Features of early postischemic cardiac remodeling is well studied both in the clinic and in the experiment. However, the data for this process in the first 60 minutes after occlusion of the coronary vessel in the literature are absent practically. In experiments in rats in which acute myocardial ischemia was reproduced... |
13,333 | The effects of atrial ganglionated plexi stimulation on ventricular electrophysiology in a normal canine heart. | Atrial ganglionated plexi (GP) have been shown to modulate atrial electrophysiology and play an important role in atrial fibrillation initiation and maintenance. The purpose of this study was to investigate the effects of atrial GP stimulation (GPS) on ventricular refractoriness, restitution properties and electrical a... |
13,334 | Prognostic value of endocardial voltage mapping in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. | Endocardial voltage mapping (EVM) identifies low-voltage right ventricular (RV) areas, which may represent the electroanatomic scar substrate of life-threatening tachyarrhythmias. We prospectively assessed the prognostic value of EVM in a consecutive series of patients with arrhythmogenic right ventricular cardiomyopat... |
13,335 | Mitral annular calcification and incident ischemic stroke in treated hypertensive patients: the LIFE study. | Background Fibro-calcification of the mitral annulus (MAC) has been associated with increased risk of ischemic stroke in general populations. This study was performed to assess whether MAC predicts incidence of ischemic stroke in treated hypertensive patients with left ventricular hypertrophy (LVH). Methods Baseline an... |
13,336 | Prevalence of echocardiographic left-atrial enlargement in hypertension: a systematic review of recent clinical studies. | Left atrial enlargement (LAE) is a marker of hypertensive heart disease associated with increased cardiovascular risk. We reviewed recent literature about the prevalence of LAE, as assessed by echocardiography, to update our information about the clinical relevance of this cardiac phenotype in human hypertension.</Abst... |
13,337 | Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias. | The atria contribute 25% to ventricular stroke volume and are the site of the commonest cardiac arrhythmia, atrial fibrillation (AF). The initiation of contraction in the atria is similar to that in the ventricle involving a systolic rise of intracellular Ca(2+) concentration ([Ca(2+)](i)). There are, however, substant... |
13,338 | Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores. | Strokes develop even in patients with low CHADS₂ scores, and the left atrial appendage (LAA) is the embolic source 90% of the time. We focused on the LAA morphology as a new predictor of strokes.</AbstractText>To clarify the anatomical characteristics of the LAA for risk stratification of strokes in patients wit... |
13,339 | [Survival of out-hospital cardiac arrests attended by a mobile intensive care unit in Asturias (Spain) in 2010]. | To evaluate attendance timings, out- and in-hospital characteristics, and survival of cardiac arrests attended by an advanced life support unit in Asturias (Spain) in 2010. Factors related to survival upon admission and at discharge were also analyzed.</AbstractText>A retrospective, observational trial was carried out ... |
13,340 | In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category I-II. | Donations after circulatory death (DCD) lung grafts are an alternative to extend the donor pool in lung transplantation. This study investigates the use of an in situ lung perfusion system (ISLP) in the donor to evaluate category I-II lungs. Pigs were sacrificed by ventricular fibrillation. All animals underwent 20
... |
13,341 | Differences in clinical and echocardiographic parameters between paroxysmal and persistent atrial flutter in the AURUM 8 study: targets for prevention of persistent arrhythmia? | Cavotricuspid isthmus-dependent atrial flutter (AFL) can occur in a paroxysmal or persistent pattern. The aim of this study was to identify clinical, echocardiographic, and electrophysiological risk factors independently associated with persistence of AFL.</AbstractText>Patients of the recently published AURUM 8 study ... |
13,342 | Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs. | Chronic hyperglycemia in type-1 diabetes mellitus is associated with oxidative stress (OS) and sudden death. Mechanistic links remain unclear. We investigated changes in electrophysiological (EP) properties in a model of chronic hyperglycemia before and after challenge with OS by GSH oxidation and tested reversibility ... |
13,343 | Ischemic post-conditioning and vasodilator therapy during standard cardiopulmonary resuscitation to reduce cardiac and brain injury after prolonged untreated ventricular fibrillation. | We investigated the effects of ischemic postconditioning (IPC) with and without cardioprotective vasodilatory therapy (CVT) at the initiation of cardiopulmonary resuscitation (CPR) on cardio-cerebral function and 48-h survival.</AbstractText>Prospective randomized animal study. Following 15 min of ventricular fibrillat... |
13,344 | Long-term follow-up of a pediatric cohort with short QT syndrome. | The purpose of this study was to define the clinical characteristics and long-term follow-up of pediatric patients with short QT syndrome (SQTS).</AbstractText>SQTS is associated with sudden cardiac death. The clinical characteristics and long-term prognosis in young patients have not been reported.</AbstractText>This ... |
13,345 | The effect of routine magnesium supplementation on fetal cardiac time intervals: a fetal magnetocardiographic study. | Magnesium deficiency in pregnancy is frequent, and in consequence magnesium supplementation is widely used. As magnesium crosses the placental barrier and since the fetal kidney does not excrete magnesium as efficiently as the mature kidney, effects on fetal cardiac time intervals are probable, but still unknown.</Abst... |
13,346 | Extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in a sheep model of refractory ischaemic cardiac arrest. | Survival after out-of-hospital cardiac arrest remains limited. It is therefore imperative to develop new resuscitation techniques. We aimed to determine the potential role of extracorporeal membrane oxygenation assisted CPR (ECPR) in an animal model of refractory ischaemic cardiac arrest.</AbstractText>Twelve sheep wer... |
13,347 | Predicting favourable outcomes in the setting of radiofrequency catheter ablation of long-standing persistent atrial fibrillation: a pilot study assessing the value of left atrial appendage peak flow velocity. | Catheter ablation is an effective and potentially curative treatment in patients with atrial fibrillation (AF).</AbstractText>To test the hypothesis that left atrial appendage peak flow velocity (LAV) assessed by echocardiography can accurately predict successful catheter ablation as well as favourable outcome in the s... |
13,348 | Slower heart rate and altered rate dependence of ventricular repolarization in patients with lone atrial fibrillation. | Electrophysiological alterations in atrial fibrillation (AF) may be genetically based and may lead to changes in ventricular repolarization. Short QT syndrome is a rare channelopathy with abbreviated ventricular repolarization and a propensity for AF.</AbstractText>To determine if minor unrecognized forms of short QT s... |
13,349 | Higher degree of left atrial structural remodeling in patients with atrial fibrillation and left ventricular systolic dysfunction. | Catheter ablation significantly improves the left ventricular (LV) function in patients with atrial fibrillation (AF) and LV systolic dysfunction. In this study, we compared the degree of left atrial structural remodeling (LA-SRM) in patients with normal versus reduced LV ejection fraction (LVEF). We also studied the i... |
13,350 | Noninvasive panoramic mapping of human atrial fibrillation mechanisms: a feasibility report. | Recent developments in body surface mapping and computer processing have allowed noninvasive mapping of atrial activation responsible for various cardiac arrhythmias with increasingly greater resolution. We developed specific algorithms to identify localized sources and atrial propagation occurring simultaneously durin... |
13,351 | Impaired ventricular repolarization dynamics in patients with early repolarization syndrome. | Almost all current investigations on early repolarization syndrome (ERS) have focused on the J-wave characteristics and ST-segment configuration; however, few have reported on ventricular repolarization indexes in ERS.</AbstractText>A total of 145 subjects were enrolled: 10 ERS patients, 45 uneventful ER pattern (ERP) ... |
13,352 | Role of tumor necrosis factor-α in the pathogenesis of atrial fibrosis and development of an arrhythmogenic substrate. | Although tumor necrosis factor-α (TNF-α) levels are increased in patients with atrial fibrillation (AF), its role in the pathogenesis of AF is unclear. We investigated whether direct delivery of TNF-α could induce atrial fibrosis.</AbstractText>TNF-α (4 μg/kg) was injected into the tail ve... |
13,353 | Impact of defibrillation testing on predicted ICD shock efficacy: implications for clinical practice. | Lack of consensus regarding defibrillation testing methods for implantable cardioverter-defibrillators relates to risks of repeated fibrillation episodes.</AbstractText>To provide recommendations for testing protocols, repeating testing of patients with high defibrillation threshold (DFT), and interpreting testing afte... |
13,354 | The Impact of Sub-valvular Apparatus Preservation on Prosthetic Valve Dysfunction During Mitral Valve Replacement. | Sub-valvular apparatus preservation (SAP) during mitral valve replacement (MVR) is not a new concept. Some surgeons prefer to excise the apparatus.</AbstractText>The aim of this study was to reduce the risk of prosthetic valve dysfunction.</AbstractText>This retrospective study included 151 patients with the mean age o... |
13,355 | Innovations in heart rhythm disturbances: cardiac electrophysiology, arrhythmias, and cardiac pacing. | This article reviews the most relevant articles published in 2012 in the field of arrhythmias, on subjects that include clinical arrhythmology, ablation, cardiac pacing, and the genetics of sudden cardiac death. |
13,356 | The stability of electrically induced ventricular fibrillation. | The first recorded heart rhythm for cardiac arrest patients can either be ventricular fibrillation (VF) which is treatable with a defibrillator, or asystole or pulseless electrical activity (PEA) which are not. The time course for the deterioration of VF to either asystole or PEA is not well understood. Knowing the tim... |
13,357 | Essentials of low-power electrocution: established and speculated mechanisms. | Even though electrocution has been recognized--and studied--for over a century, there remain several common misconceptions among medical professional as well as lay persons. This review focuses on "low-power" electrocutions rather than on the "high-power" electrocutions such as from lightning and power lines. Low-power... |
13,358 | A ventricular activity cancellation algorithm based on event synchronous adaptive filter for single-lead electrocardiograms. | Recently, it has become very important to analyze atrial activity (AA) and to detect arrhythmic AAs and, for this, complete ventricular activity (VA) cancellation is prerequisite. There have been several VA cancellation algorithms for multi-lead ECG but VA cancellation algorithm for single-lead is quite a few. In this ... |
13,359 | Sequential algorithm for the detection of the shockable rhythms in electrocardiogram. | We suggest a sequential algorithm for the detection of the ventricular fibrillation (VF) and ventricular tachycardia (VT) of a rate above 180 bpm, so called shockable rhythms. The built-in algorithm for ECG analysis embedded in the portable bio-signal sensing module is aimed to discriminate between shockable and non-sh... |
13,360 | Single camera system for multi-wavelength fluorescent imaging in the heart. | Optical mapping has been a powerful method to measure the cardiac electrophysiological phenomenon such as membrane potential(V(m)), intracellular calcium(Ca(2+)), and the other electrophysiological parameters. To measure two parameters simultaneously, the dual mapping system using two cameras is often used. However, th... |
13,361 | Development of a patch type embedded cardiac function monitoring system using dual microprocessor for arrhythmia detection in heart disease patient. | A patch type embedded cardiac function monitoring system was developed to detect arrhythmias such as PVC (Premature Ventricular Contraction), pause, ventricular fibrillation, and tachy/bradycardia. The overall system is composed of a main module including a dual processor and a Bluetooth telecommunication module. The d... |
13,362 | Defibrillation success rates for electrically-induced fibrillation: hair of the dog. | Accidental electrocutions kill about 1000 individuals annually in the USA alone. There has not been a systematic review or modeling of elapsed time duration defibrillation success rates following electrically-induced VF. With such a model, there may be an opportunity to improve the outcomes for industrial electrocution... |
13,363 | Hysteresis in DI independent mechanisms in threshold for transition between 1:1 and 2:2 rhythms in pigs. | Previous studies have shown hysteresis in transition from 1:1 to 2:2 rhythms in action potential durations (APD) during decreasing and increasing cycle length pacing. As cycle lengths were constant, when alternans of APD occurred, so did of preceding diastolic intervals (DIs), which engaged the restitution mechanism, i... |
13,364 | Human electrophysiological and pharmacological properties of XEN-D0101: a novel atrial-selective Kv1.5/IKur inhibitor. | The human electrophysiological and pharmacological properties of XEN-D0101 were evaluated to assess its usefulness for treating atrial fibrillation (AF). XEN-D0101 inhibited Kv1.5 with an IC50 of 241 nM and is selective over non-target cardiac ion channels (IC50 Kv4.3, 4.2 μM; hERG, 13 μM; activated Nav1.5,... |
13,365 | Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology. | Oxidative stress has been implicated in the pathogenesis of heart failure and atrial fibrillation and can result in increased peroxynitrite production in the myocardium. Atrial and ventricular canine cardiac myocytes were superfused with 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), a peroxynitrite donor, to evalua... |
13,366 | Defibrillation waveform duration adjustment increases the proportion of acceptable defibrillation thresholds in patients implanted with single-coil defibrillation leads. | The aim of this study was to determine whether defibrillation waveform duration adjustment with single-coil defibrillation leads can be used to increase the proportion of patients with satisfactory defibrillation thresholds (DFTs). A retrospective analysis of the DFT levels for 105 patients with implantable cardioverte... |
13,367 | [Clinical and cardiac imaging characteristics of patients with left ventricular apical hypoplasia]. | To analyze the clinical and cardiac imaging characteristics of patients with left ventricular apical hypoplasia (LVAH).</AbstractText>From January 2008 to January 2012, seven patients [3 male/4 female, age: 6 - 44 (19.9 ± 14.2) years] with LVAH were included in this cohort. Transthoracic echocardiogram was perform... |
13,368 | Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases. | To compare the degree of mRNA expression for matrix metalloproteinases (MMPs), tissue inhibitors (TIMPs), and lysyl oxidase in myocardial samples from dogs with cardiac and systemic diseases and from healthy control dogs.</AbstractText>Myocardial samples from the atria, ventricles, and septum of 8 control dogs, 6 dogs ... |
13,369 | Aborted sudden cardiac death due to radiofrequency ablation within the coronary sinus and subsequent total occlusion of the circumflex artery. | We report a case of aborted sudden cardiac death and subsequent development of malignant drug-refractory incessant ventricular tachycardia/fibrillation in a patient with acute coronary artery occlusion following radiofrequency ablation within the CS. Catheter ablation is a well-established therapy for treatment of atri... |
13,370 | Clinical factors associated with left ventricular ejection fraction disparity in patients with left ventricular dysfunction undergoing multimodality imaging. | Drug and device therapy for heart failure is increasingly determined based on left ventricular ejection fraction. Significant disparity frequently exists between echocardiographic and nuclear scintigraphic techniques, even when testing is performed nearly simultaneously in clinically stable patients. In 119 patients wi... |
13,371 | Prehospital electrocardiographic manifestations of acute myocardial ischemia independently predict adverse hospital outcomes. | Prehospital electrocardiography (PH ECG) is becoming the standard of care for patients activating Emergency Medical Services for symptoms of acute coronary syndrome (ACS). Little is known about the prognostic value of ischemia found on PH ECG.</AbstractText>The purpose of this study was to determine whether manifestati... |
13,372 | Susceptibility to ischemia-induced ventricular fibrillation in isolated female rat hearts varies moderately with estrous cycle stage. | The vast majority of studies employing the isolated perfused rat heart model to study ischemic arrhythmias have used male rats only. The objective of this study was to determine the susceptibility to ischemia-induced ventricular fibrillation (VF) in isolated female rat hearts in each stage of the estrous cycle that cor... |
13,373 | Acute myocardial infarction as presentation of an infiltrative lung neoplasia. | We report the case of a 51-year-old woman who presented with acute myocardial infarction as initial symptom of an infiltrative lung neoplasia. The patient was admitted to our center following an out-of-hospital cardiac arrest due to ventricular fibrillation which was cardioverted. On electrocardiography an anterior wal... |
13,374 | Defibrillation success with high frequency electric fields is related to degree and location of conduction block. | We recently demonstrated that high frequency alternating current (HFAC) electric fields can reversibly block propagation in the heart by inducing an oscillating, elevated transmembrane potential (Vm) that maintains myocytes in a refractory state for the field duration and can terminate arrhythmias, including ventricula... |
13,375 | Routine preprocedural transesophageal echocardiography might not be necessary for stroke prevention evaluation in AF patients on anticoagulation therapy. | Preprocedural transesophageal echocardiography (TEE) is used to reduce the stroke during atrial fibrillation (AF) ablation. This study evaluated whether routine preprocedural TEE in addition to multidetector computed tomography (MDCT) is necessary to prevent periprocedural stroke in AF ablation.</AbstractText>Each pati... |
13,376 | Specific organized substrates of ventricular fibrillation: comparison of 320-slice CT heart images in non-ischemic ventricular fibrillation subjects with non-ischemic sustained and non-sustained ventricular tachycardia subjects. | If specific organized substrates of ventricular-fibrillation (VF) are identified, they may provide important-information for prevention of sudden-cardiac-death. To identify specific organized substrates of VF, we compared 320-slice CT heart images in non-ischemic VF subjects with non-ischemic sustained and non-sustaine... |
13,377 | Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): an on-treatment analysis. | In the Ventricular Tachycardia Ablation in Coronary Heart Disease (VTACH) study, an intention-to-treat approach was used and may have diminished the observed degree of treatment effect. We present a subanalysis of the VTACH study by treatment actually received.</AbstractText>The VTACH study was a prospective, open, ran... |
13,378 | A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation. | Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its incidence is expected to grow. A genetic predisposition for AF has long been recognized, but its manifestation in these patients likely involves a combination of rare and common genetic variants. Identifying genetic variants that associate with a h... |
13,379 | Long-term prognostic value of restitution slope in patients with ischemic and dilated cardiomyopathies. | An action potential duration (APD) restitution curve with a steep slope ≥1 has been associated with increased susceptibility for malignant ventricular arrhythmias. We aimed to evaluate the "restitution hypothesis" and tested ventricular APD restitution slope as well as effective refractory period (ERP)/APD ratio... |
13,380 | Osborn waves during therapeutic hypothermia in a young ST-ACS patient after out-of-hospital cardiac arrest. | A 37 year-old male patient was admitted to the intensive care unit after an out-of-hospital cardiac arrest due to ventricular fibrillation in a course of ST-segment elevation acute coronary syndrome. On admission, the patient was unconscious with a Glasgow Coma Scale (GCS) score of 5. A percutaneous coronary interventi... |
13,381 | Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: atrial fibrillation type determines the success rate. | Atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) is generally associated with deterioration of the clinical status, functional capacity, and quality of life. It is also an independent risk factor for stroke and death. Studies evaluating the effectiveness of AF ablation in this cohort are rela... |
13,382 | Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide. | Drugs not commonly considered to be cardioactive agents may cause prolongation of the QT interval with resultant torsades de pointes and ventricular fibrillation. This form of drug toxicity often causes cardiac arrest or sudden death.</AbstractText>After accidental ingestion of tosylchloramide a caucasian 77-year-old w... |
13,383 | Ventricular extrasystoles with interpolation or postponed compensatory pause during atrial fibrillation: fact or fiction? | A Holter recording obtained from a patient with atrial fibrillation showed ventricular extrasystoles often in bigeminal rhythm. Most extrasystoles were followed by a long return cycle, and only in a few instances the postextrasystolic interval was short. The latter phenomenon was interpreted as a manifestation of poor ... |
13,384 | Association between atrial fibrillatory rate and heart rate variability in patients with atrial fibrillation and congestive heart failure. | Even if atrial fibrillatory rate (AFR) has been related to clinical outcome in patients with atrial fibrillation (AF), its relation with ventricular response has not been deeply studied. The aim of this study was to investigate the relation between AFR and RR series variability in patients with AF.</AbstractText>Twenty... |
13,385 | Surgical timing of degenerative mitral regurgitation: what to consider. | Severe primary mitral regurgitation (MR) is a progressive condition which engenders significant mortality and morbidity if left untreated. The optimal timing of surgery in patients with MR of degenerative origin continues to be debated, especially for those who are asymptomatic. Apart from symptoms, current authoritati... |
13,386 | Management of moderate secondary mitral regurgitation at the time of aortic valve surgery. | To define the impact of surgical strategy [concomitant mitral valve surgery or isolated aortic valve replacement (AVR)] in patients with moderate secondary mitral regurgitation (MR) at the time of AVR.</AbstractText>From January 1999 to December 2009, 3339 patients underwent AVR of whom 255 had secondary MR >2+ and ... |
13,387 | Utility of NT-proBNP for identifying LV failure in patients with acute exacerbation of chronic bronchitis. | NT-proBNP has been widely regarded as a useful tool for diagnosis or exclusion of heart failure (HF) in many settings. However, in patients with acute exacerbation of chronic bronchitis (AECB), its roles have not been well described. The objective of this study was to evaluate the diagnostic performance of NT-proBNP fo... |
13,388 | Atrial selectivity in Na+channel blockade by acute amiodarone. | Na(+) channel blockers are often used to treat atrial fibrillation (AF), but may sometimes cause ventricular contractile dysfunction. However, amiodarone, a multi-channel blocker with Na(+) channel block, causes less contractile dysfunction. In this study, we tested the hypothesis that Na(+) channel block by amiodarone... |
13,389 | Magnetic resonance imaging in clinical cardiac electrophysiology. | Radiofrequency ablation is routinely used to treat numerous cardiac arrhythmias originating in the atrium and the ventricle. The process of ablation was pioneered to treat supraventricular tachycardias originating from fixed electrical circuits. These circuits could be identified using innovative electrophysiological m... |
13,390 | Evaluation of patients with cardiac amyloidosis using echocardiography, ECG and right heart catheterization. | To characterize patients with cardiac amyloidosis using echocardiography, electrocardiogram (ECG) and right heart catheterization (RHC).</AbstractText>Fourteen patients with biopsy verified light chain or transthyretin cardiac amyloidosis were included. All patients had heart failure with markedly elevated NT-proBNP. E... |
13,391 | Catheter ablation of ventricular fibrillation storm in a long QT syndrome genotype carrier with normal QT interval. | Patients with long QT syndrome can sometimes present with a ventricular fibrillation (VF) storm. Catheter ablation of culprit premature ventricular complexes responsible for the triggering of the VF episodes may be required in rare cases of electrical storm that do not respond to conventional measures, and this can be ... |
13,392 | Early detection of ischemia by implantable cardioverter defibrillator capable of intracardiac electrogram monitoring in a case of old myocardial infarction. | A 72-year-old man received an implantation of implantable cardioverter defibrillator with intracardiac electrogram (ICEG) monitoring because ventricular fibrillation occurred in a case of old myocardial infarction with reduced left ventricular function. A year later, he came to our hospital for a regular checkup. Unexp... |
13,393 | [Magnetic resonance imaging of dilated cardiomyopathy]. | Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy with a prevalence of 1 out of 2,500 in adults. Due to mild clinical symptoms in the early phase of the disease, the true prevalence is probably even much higher. Patients present with variable clinical symptoms ranging from mild systolic impairment ... |
13,394 | Clinical significance of the assessment of the systolic and diastolic myocardial function of the left atrium in patients with paroxysmal atrial fibrillation and low CHADS(2) index treated with catheter ablation therapy. | The purpose of this study was to determine the clinical significance of the assessment of the diastolic and systolic myocardial function of the left atrium in patients with paroxysmal atrial fibrillation (AF) and low CHADS(2) scores treated with catheter ablation therapy. In a cohort of 84 symptomatic patients with par... |
13,395 | Impact of shock energy and ventricular rhythm on the success of first shock therapy: the ALTITUDE first shock study. | The efficacy of shock in converting different ventricular tachyarrhythmias has not been well characterized in a large natural-practice setting.</AbstractText>To determine shock success rate by energy and ventricular rhythm in a large cohort of patients with implantable cardioverter-defibrillators.</AbstractText>Two tho... |
13,396 | A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). | In the present study, we investigated whether a new biomarker - index of cardiac electrophysiological balance (iCEB=QT/QRS) - could predict drug-induced cardiac arrhythmias (CAs), including ventricular tachycardia/ventricular fibrillation (VT/VF) and Torsades de Pointes (TdPs).</AbstractText>The rabbit left ventricular... |
13,397 | [Mortality of interventricular septum rupture after acute myocardial infarction with surgical management]. | ventricular septal rupture is a rare complication of myocardial infarction. It is considered the most serious mechanical disturbance in these cases. The mortality of patients during the hospital period receiving surgical treatment for this complication is described.</AbstractText>a case series study, including patients... |
13,398 | Echocardiographic parameters to predict inadequate defibrillation safety margin in patients receiving implantable cardioverter defibrillators for primary prevention. | Implantable cardioverter defibrillators (ICDs) have become an important part of the management of patients with congestive heart failure. At the time of ICD implantation, ventricular fibrillation (VF) is induced to assess adequate energy required for defibrillation. There are multiple parameters which influence the def... |
13,399 | "GIOSAT": a tool to assess CanMEDS competencies during simulated crises. | Our objective was to develop and evaluate a Generic Integrated Objective Structured Assessment Tool (GIOSAT) to integrate Medical Expert and intrinsic (non-medical expert) CanMEDS competencies with non-technical skills for crisis simulation.</AbstractText>An assessment tool was designed and piloted using two pediatric ... |
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