Unnamed: 0
int64
0
2.34M
titles
stringlengths
5
21.5M
abst
stringlengths
1
21.5M
15,200
Effects of lüfukang capsules on coronary artery ligation-induced arrhythmia in dogs.
To observe the effects of L&#xfc;fukang Capsules on arrhythmia induced by ligation of coronary artery in dogs.</AbstractText>Thirty dogs were randomly divided into 5 groups, the model group administrated with equal volume of distilled water, the positive control group administrated with Wenxin Granules, and the small, ...
15,201
A serious medicolegal problem after surgery: gossypiboma.
After surgery, the most common foreign bodies retained in the abdominal cavity are the surgical sponges. The aim of the present study was to emphasize the importance of gossypiboma, which is a serious and medicolegal problem. The records of 12 patients with a confirmed diagnosis of gossypiboma after abdominal surgery a...
15,202
Atrial fibrillation and heart failure parallels: lessons for atrial fibrillation prevention.
Heart failure (HF) and atrial fibrillation (AF) are 2 of the most common cardiovascular diseases encountered in clinical practice, and the prevalence of these diseases continues to grow worldwide with the aging of the global population. While recognizing that AF is a heterogeneous disorder, we submit that the parallels...
15,203
Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: role of myocyte structure and myocardial perfusion.
We showed previously that ivabradine (IVA), a selective inhibitor of the cardiac pacemaker I(f) current, achieved protection against ischaemia-induced ventricular fibrillation (VF) in pigs by increasing the VF threshold (VFT). This was correlated to the heart rate reduction (HRR), the limitation of monophasic action po...
15,204
Surgery for ischemic mitral regurgitation: should the valve be repaired?
Patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (CABG) often have concomitant mitral regurgitation (MR). Repairing the valve at the time of surgery is not universally accepted. The results of CABG with or without mitral valve annuloplasty (MVA) were compared in patients with reduced lef...
15,205
Preventing sudden death in the adult with congenital heart disease.
Adults with repaired congenital heart disease represent a complex and heterogeneous group of patients that are increasingly surviving beyond childhood. Patients have a variety of diagnoses that include specific structural anomalies, assorted physiologic derangements, and unique techniques for surgical repair. During lo...
15,206
Rate control in atrial fibrillation by cooling: effect of temperature on dromotropy in perfused rabbit hearts.
Background. Cooling has emerged as a therapeutic option in critically ill patients (especially after cardiac resuscitation) and might also have a negative dromotropic effect in atrial fibrillation. We sought to determine the impact of cooling on electrophysiologic properties of Langendorff-perfused rabbit hearts. Metho...
15,207
Incidence and clinical relevance of uncontrolled ventricular rate during atrial fibrillation in heart failure patients treated with cardiac resynchronization therapy.
Uncontrolled ventricular rate (VR) during atrial fibrillation (AF) may cause clinical deterioration in heart failure (HF) patients who need continuous biventricular pacing to achieve cardiac resynchronization therapy (CRT). We aimed at evaluating the association between AF, uncontrolled VR, and sub-optimal CRT, defined...
15,208
Cardiac arrest as a result of ventricular tachycardia in a trauma patient.
Cardiac arrest is classified based on whether it is treatable using defibrillation or not. It is classified as shockable rhythm (ventricular fibrillation and pulseless ventricular tachycardia, or non-shockable (asystole and pulseless electrical activity). We present a case of a 72-year-old male Saudi patient not known ...
15,209
Ablation of Premature Ventricular Complexes Triggering Ventricular Fibrillation in a Patient with Long QT Syndrome.
We describe the case of a patient with long QT syndrome and recurrent ventricular fibrillation, triggered by premature ventricular complexes (PVCs) with a left bundle branch block pattern and inferior axis of the QRS. Activation mapping demonstrated the origin of the PVCs to be in the right ventricular outflow tract. V...
15,210
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Electrical storm (ES), characterized by recurrent ventricular tachycardia/fibrillation, typically occurs in implantable cardioverter-defibrillator patients and adversely affects prognosis. However, the underlying molecular basis is poorly understood. In the present study, we report a new experimental model featuring re...
15,211
Acute bioprosthetic mitral valve stenosis in a patient with HITS.
Acute thrombosis involving the left atrium and a bioprosthetic valve during the early postoperative period is an extremely rare complication of heparin-induced thrombocytopenia syndrome (HITS). We present a patient with early bioprosthetic mitral valve stenosis complicated by HITS in a patient with severe mitral regurg...
15,212
Resting heart rate is a powerful predictor of arrhythmic events in patients with dilated cardiomyopathy and implantable cardioverter-defibrillator.
Patients with dilated cardiomyopathy and implantable cardioverter-defibrillator (ICD) are a high-risk group for arrhythmias. They regularly undergo cardiopulmonary exercise testing (CPET) to assess cardiac reserve and to guide clinical decisions or therapeutic adjustments. Data from previous studies demonstrate that pr...
15,213
Oscillatory vagal maneuvers produce ventricular entrainment in patients with atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained dysrhythmia and appears to be an independent predictor of sudden cardiac death. The irregular ventricular rhythm contains both linear and non-linear patterns; however, it remains unclear whether vagally mediated effects are present within these patterns.</AbstractTe...
15,214
[NT-Pro-BNP levels performance before and after reversion to sinus rhythm in patients with preserved ventricular function].
Our objective was to evaluate changes of N-terminal pro-BNP (NT-Pro-BNP) levels at baseline and after restoration to sinus rhythm in hemodynamic stable patients with lone atrial fibrillation (LAF) with preserved left ventricular function. NT-Pro-BNP levels were obtained before and after cardioversion in thirty hemodyna...
15,215
Hypothermia and neuroprotection by sulfide after cardiac arrest and cardiopulmonary resuscitation.
Poor neurological outcome remains a major problem in patients suffering cardiac arrest. Recent data have demonstrated potent neuroprotective effects of the administration of sulfide donor compounds after ischaemia/reperfusion injury following cardiac arrest and resuscitation. Therefore, we sought to evaluate the impact...
15,216
Myocardial extraction of intracellular magnesium and atrial fibrillation after coronary surgery.
The effects of magnesium loading on the incidence of atrial fibrillation following coronary artery bypass graft surgery (CAGB) are equivocal. None of the previous studies assessed the influence of myocardial extraction of magnesium in these settings. The current trial aims to elucidate whether the incidence of atrial f...
15,217
Pathophysiologic changes due to TASER&#xae; devices versus excited delirium: potential relevance to deaths-in-custody?
The syndrome of excited delirium has been implicated in some deaths-in-custody which also involved the use of electronic control devices (ECDs) (including those manufactured by TASER International) on subjects. This review is an update on recent studies of pathophysiologic changes related to these two separate but para...
15,218
Effects of sustained abdominal aorta compression on coronary perfusion pressures and restoration of spontaneous circulation during cardiopulmonary resuscitation in swine.
The present study was undertaken to explore whether sustained abdominal aorta compression-cardiopulmonary resuscitation (SAAC-CPR), as a means, can raise coronary perfusion pressure (CPP) as well as restoration of spontaneous circulation (ROSC) during CPR. In the present study, we hypothesised that SAAC-CPR elevates CP...
15,219
[EAHFE (Epidemiology Acute Heart Failure Emergency) study: analysis of the patients with echocardiography performed prior to an emergency visit due to an episode of acute heart failure].
Analyze the clinical profile and short-term evolution of the patients attended in the Spanish Hospital Emergency Services (SHES) due to an episode of acute heart failure (AHF) based on whether these patients had undergone or not an echocardiography and on the ventricular function estimated in said ultrasonography.</Abs...
15,220
The quality of defibrillation performance among students of the University of Medical Sciences.
The major objective was to assess the time period from a witnessed ventricular fibrillation (VF) to the first defibrillation (DEF) in a simulated manikin scenario, while the minor objective was to analyze the most common errors that occurred during DEF and the maintenance of 2-min intervals during resuscitation. We exa...
15,221
A study to determine chest wall vibratory attachment interface locations for a low frequency sonic vibrator in treatment of acute coronary thrombosis.
Our institution is developing a non-invasive Diastolic Timed Vibrator (DTV) to enhance emergency clearance of acute coronary thrombosis. Sonic frequency diastolic vibro-percussion (i.e. 50&#xa0;Hz, 2&#xa0;mm amplitude) applied upon the rib-spaces of the left sternal border has shown to improve left ventricular performa...
15,222
A model of survival from out-of-hospital cardiac arrest using the Boston EMS arrest registry.
To characterize the survival rate for out-of-hospital arrests of cardiac aetiology and predictor variables associated with survival in Boston, MA, and to develop a composite multivariate logistic regression model for projecting survival rates.</AbstractText>This is a retrospective analysis of all arrests of presumed ca...
15,223
Usefulness of mild therapeutic hypothermia for hospitalized comatose patients having out-of-hospital cardiac arrest.
Mild therapeutic hypothermia has proved beneficial after out-of-hospital cardiac arrest in the adult population, when the initial rhythm is ventricular fibrillation (VF). In this study, data from 110 consecutive patients with out-of-hospital cardiac arrest due to VF (n = 86) or to non-VF rhythm (n = 24), admitted to an...
15,224
Collapse-to-emergency medical service cardiopulmonary resuscitation interval and outcomes of out-of-hospital cardiopulmonary arrest: a nationwide observational study.
The relationship between collapse to emergency medical service (EMS) cardiopulmonary resuscitation (CPR) interval and outcome has been well documented. However, most studies have only analyzed cases of cardiac origin and Vf (ventricular fibrillation)/pulseless VT (ventricular tachycardia). We sought to examine all caus...
15,225
Assessment of right atrial pressure using echocardiography and correlation with catheterization.
Right ventricular systolic pressure is crucial for both treatment and prognosis of cardiovascular and pulmonary diseases. The proper measurement of right ventricular systolic pressure depends on an accurate estimation of right atrial pressure (RAP). There is no standard method for estimating RAP noninvasively. The purp...
15,226
Reduction of myocardial infarct size by dronedarone in pigs--a pleiotropic action?
Dronedarone is a first-line drug to prevent the recurrence of atrial fibrillation according to ESC guidelines. In the recent ATHENA trial, dronedarone reduced mortality and also hospitalization for acute coronary syndrome in patients with atrial fibrillation. This beneficial effect suggests that dronedarone might have ...
15,227
Suppression of cautery-induced electromagnetic interference of cardiac implantable electrical devices by closely spaced bipolar sensing.
Electromagnetic interference (EMI) induced by electrocautery during surgery in patients with cardiac pacemakers or implanted cardioverter-defibrillators (ICDs) may inhibit pacing and cause inappropriate tachyarrhythmia oversensing. In particular, susceptibility to EMI may be enhanced in ICDs by frequently used wide int...
15,228
Acute right ventricular myocardial injury and sudden cardiac arrest in a patient with persistent spontaneous coronary vasospasm.
Coronary vasospasm is a rare diagnosis resulting in sudden arrhythmic cardiac arrest. We report a case of a healthy, non-smoking elderly woman resuscitated from arrhythmic cardiac arrest. She had persistent spontaneous coronary vasospasm, leading to right ventricular myocardial injury and failure, and shock. She respon...
15,229
[The role of dronedarone in the contemporary atrial fibrillation treatment].
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the daily medical practice associated with increased cardiovascular mortality and stroke. Till now amiodarone is generally considered as the agent with the best efficacy for maintaining sinus rhythm. Despite its efficacy, amiodarone use is often limited ...
15,230
Feasibility of TEE-guided stroke risk assessment in atrial fibrillation-background, aims, design and baseline data of the TIARA pilot study.
Antithrombotic management in atrial fibrillation (AF) is currently based on clinical characteristics, despite evidence of potential fine-tuning with transoesophageal echocardiography (TEE). This open, randomised, multicentre study addresses the hypothesis that a comprehensive strategy of TEE-based aspirin treatment in ...
15,231
Brugada type 1 electrocardiographic pattern induced by severe hyponatremia.
Brugada syndrome is characterized electrocardiographically by ST segment elevation in the right precordial leads, followed by a negative T wave unrelated to ischemia, electrolyte disturbance or drug effects and prone to rapid polymorphic ventricular tachycardia capable of degenerating into ventricular fibrillation. The...
15,232
Heart rate turbulence can predict cardiac mortality following myocardial infarction in patients with diabetes mellitus.
Previous studies have described the clinical utility of heart rate turbulence (HRT) as an autonomic predictor in risk-stratifying patients after myocardial infarction (MI). Some reports showed that diabetes mellitus (DM) affects the prognostic value of autonomic markers. We assessed the utility of HRT as a risk marker ...
15,233
Atrial Fibrillation in the Wolff-Parkinson-White Syndrome.
Since the advent of catheter ablation for atrial fibrillation (AF) aiming the pulmonary veins a few years ago, there has been an overwhelming interest and a dramatic increase in AF investigation. AF has a different dimension in the context of the Wolff-Parkinson-White (WPW) syndrome. Indeed, AF may be a nightmare in a ...
15,234
Determinants and outcome of amiodarone-associated thyroid dysfunction.
Amiodarone is frequently associated with thyroid dysfunction. Identifying predictors for amiodarone-associated thyroid dysfunction and assessing treatment outcome may aid clinicians in daily practice.</AbstractText>We included 303 consecutive patients with amiodarone therapy for cardiac arrhythmias (260 with atrial fib...
15,235
Predictors of all-cause 1-year mortality in implantable cardioverter defibrillator patients with chronic Chagas' cardiomyopathy.
Implantable cardioverter defibrillators (ICDs) have been used in the treatment of either sustained ventricular tachycardia or ventricular fibrillation in patients with Chagas' cardiomyopathy. This study aimed at determining mortality rate and risk factors of all-cause 1-year mortality in primary and secondary ICD patie...
15,236
[Atrial fibrillation surgery].
Atrial fibrillation surgery is based on creating scars in the atrium, in order to avoid re-entry phenomena that may initiate and perpetuate arrhythmia, and driving the normal stimuli from the sinus node to the atrio-ventricular node. The complexity and increased risk of the initial surgical technique, based on a "cut-a...
15,237
[An effective and safe alternative to epicardial pacemaker placement for permanent pacemaker implantation in a patient with mechanical tricuspid valve: stimulation of the left ventricle through the coronary sinus].
Implantation of a transvenous endocardial pacemaker is contraindicated in patients with a mechanical tricuspid valve. An epicardial left ventricular pacemaker lead was placed by a transvenous route through the coronary sinus into the lateral cardiac vein in a 58-year-old woman with mechanical aortic, mitral, and tricus...
15,238
Prevalence and determinants of incomplete right atrial reverse remodeling after device closure of atrial septal defects.
Whether the relief of chronic right atrial (RA) volume load by device closure of an atrial septal defect (ASD) normalizes RA size is unknown. The present study evaluated the prevalence and determinants of incomplete RA reverse remodeling (RAR) after ASD closure in adults. Transthoracic echocardiography was performed in...
15,239
Catheter ablation of electrical storm in a collaborative hospital network.
An electrical storm (ES) is defined as multiple ventricular arrhythmia episodes leading to implantable cardioverter defibrillator interventions. Although conventional rhythm stabilization might be of help acutely, ES involves high mortality and morbidity. We evaluated the effect of catheter ablation strategies in the s...
15,240
Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children. A comprehensive, prospective, population-based study in the Netherlands.
This study sought to determine comprehensively the incidence of pediatric out-of-hospital cardiac arrest (OHCA) and its contribution to total pediatric mortality, the causes of pediatric OHCA, and the outcome of resuscitation of pediatric OHCA patients.</AbstractText>There is a paucity of complete studies on incidence,...
15,241
[Heart and kidney--only together they are strong. On the cardiorenal and renocardiac syndrome. Case 5/2011].
We report on two patients with cardiorenal and renocardiac syndrome, respectively, who were treated with peritoneal dialysis.</AbstractText>Patient 1 suffered from dilated cardiomyopathy with an ejection fraction of 20%. There was no hint for an intrinsic renal disease, urinalysis showed microalbuminuria at the most. D...
15,242
Increased short-term variability of the QT interval in professional soccer players: possible implications for arrhythmia prediction.
Sudden cardiac death in competitive athletes is rare but it is significantly more frequent than in the normal population. The exact cause is seldom established and is mostly attributed to ventricular fibrillation. Myocardial hypertrophy and slow heart rate, both characteristic changes in top athletes in response to phy...
15,243
Update on subclinical hyperthyroidism.
Subclinical hyperthyroidism is defined by low or undetectable serum thyroid-stimulating hormone levels, with normal free thyroxine and total or free triiodothyronine levels. It can be caused by increased endogenous production of thyroid hormone (as in Graves disease or toxic nodular goiter), administration of thyroid h...
15,244
Congenital mitral valve regurgitation in adult patients.
Congenital mitral valve regurgitation (MVR) is a rare disease found in adults. We report on our 5-year surgical experience with congenital MVR in adults.</AbstractText>We reviewed the data for 48 consecutive patients (26 men), aged &gt;18 years (median, 42 years; range, 18-78 years) who underwent operations for severe ...
15,245
Immediate defibrillation or defibrillation after cardiopulmonary resuscitation.
This study aimed to determine whether short cardiopulmonary resuscitation (CPR) by emergency medical services before defibrillation (CPR first) has a better outcome than immediate defibrillation followed by CPR (shock first) in patients with ventricular fibrillation/pulseless ventricular tachycardia (VF/pulseless VT) o...
15,246
Correlation between N-Terminal Pro-Brain Natriuretic Peptide and Doppler Echocardiographic Parameters of Left Ventricular Filling Pressure in Atrial Fibrillation.
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with diastolic dysfunction even with a normal left ventricular (LV) ejection fraction. The N-terminal pro-brain natriuretic peptide (NT-proBNP) level and Dop...
15,247
Slowing of Electrical Activity in Ventricular Fibrillation is Not Associated with Increased Defibrillation Energies in the Isolated Rabbit Heart.
Prolonged out-of-hospital ventricular fibrillation (VF) arrests are associated with reduced ECG dominant frequency (DF) and diminished defibrillation success. Partial reversal of ischemia increases ECG DF and improves defibrillation outcome. We have investigated the metabolic components of ischemia responsible for the ...
15,248
Clinical utility of exercise training in chronic systolic heart failure.
The volume of literature attesting to the clinical benefits of exercise training in patients with stable chronic heart failure (CHF) is substantial. Training can improve symptoms and exercise capacity, as well as reducing morbidity, mortality, and rates of emergency hospitalization. These benefits are apparent in all p...
15,249
Single dose of ibutilide for conversion of persistent atrial fibrillation after radiofrequency ablation.
Patients with persistent or permanent atrial fibrillation (AF) often need direct current cardioversion after radiofrequency ablation. The aim of this study was to investigate the effectiveness and safety of ibutilide for cardioversion of persistent or permanent atrial fibrillation after radiofrequency ablation and the ...
15,250
Update in cardiopulmonary resuscitation.
Despite the passage of 50 years since the introduction of closed chest compression and mouth-to-mouth rescue breathing as the techniques of modern cardiopulmonary resuscitation (CPR), the simple techniques remain the backbone of successful resuscitation of victims of cardiac arrest. In particular, the importance of hig...
15,251
[Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced ventricular arrhythmias in rats].
To investigate the effect of fluvastatin on lysophosphatidylcholine (LPC)-induced ventricular arrhythmias and its mechanism.</AbstractText>Twenty male SD rats were randomly allocated into two equal groups, namely LPC treatment group and fluvastatin pretreatment group. Langendorff apparatus was used for cardiac perfusio...
15,252
Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy: association with insulin resistance.
We undertook a cross-sectional study to test the hypothesis that patients with hypertrophic cardiomyopathy (HCM) who have impaired left ventricular (LV) diastolic function are insulin resistant. We also evaluated the relation between the development of atrial fibrillation (AF) and insulin resistance (IR) in patients wi...
15,253
Successful electrical cardioversion in a massive concentric hypertrophic cardiomyopathy with atrial fibrillation.
A 59-year-old man with a known history of nonobstructive hypertrophic cardiomyopathy and chronic atrial fibrillation was admitted to our clinic with weakness, palpitation, and exertional dyspnea. Electrocardiogram showed atrial fibrillation with high ventricular rate (120 beats per minute), intraventricular conduction ...
15,254
An uncommon cause of myocardial infarction.
A 73 year-old lady with hypertension and chronic atrial fibrillation (AF) developed chest pain followed by ventricular fibrillation (VF) cardiac arrest. Her electrocardiogram post-cardioversion revealed inferior ST-elevation myocardial infarction (MI). Her coronary arteries were angiographically normal. Contrast-enhanc...
15,255
Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6.
In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial idiopathic ventricular fibrillation determines an intriguing subset of the inheritable arrhythmia syndromes as there is no recognisable phenotype during cardiologica...
15,256
Sudden death due to coronary tree hypoplasia.
A 20-year-old woman complained for several weeks before her death of unspecific epigastric pains. Such episodes were labeled as "dyspeptic episode." A month later, once again she started to complain about stomach pains, then she collapsed unconscious. She was rushed to a hospital, where she was admitted in cardiorespir...
15,257
A rare case of thyrotoxic periodic paralysis presenting to the medical examiner.
Thyrotoxic periodic paralysis is a rare and dramatic complication of hyperthyroidism. Thyrotoxic periodic paralysis classically presents with proximal lower limb weakness in the setting of hypokalemia and thyrotoxicosis. Thyrotoxic periodic paralysis represents an endocrine emergency with a rapidly ascending paralysis ...
15,258
PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.
Pitx2 is a homeobox transcription factor that plays a pivotal role in early left/right determination during embryonic development. Pitx2 loss-of-function mouse mutants display early embryonic lethality with severe cardiac malformations, demonstrating the importance of Pitx2 during cardiogenesis. Recently, independent g...
15,259
Apical hypertrophic cardiomyopathy: prevalence and correlates of apical outpouching.
Apical outpouching, including wall motion abnormalities and aneurysms, has been described in apical hypertrophic cardiomyopathy (ApHCM).</AbstractText>Between 1976 and 2006, 193 patients with ApHCM (120 men; overall mean age, 61 &#xb1; 17 years) were evaluated.</AbstractText>Apical outpouching was found in 29 patients ...
15,260
Late postoperative atrial fibrillation after cardiac surgery: a national survey within the cardiac rehabilitation setting.
The aims of this study were to determine the incidence and clinical predictors of new-onset and recurrent late postoperative atrial fibrillation (POPAF) in a large cohort of patients who underwent cardiac rehabilitation programs (CRPs) after discharge from surgery units, and the association between late POPAF and cardi...
15,261
Neurologic recovery following prolonged out-of-hospital cardiac arrest with resuscitation guided by continuous capnography.
A 54-year-old man with no known cardiac disease collapsed outdoors in a small rural community. The cardiac arrest was witnessed, and immediate cardiopulmonary resuscitation was begun by a bystander and a trained first responder who was nearby. The patient was moved into a building across the street for continued resusc...
15,262
Asphyxial cardiac arrest, resuscitation and neurological outcome in a Landrace/Large-White swine model.
The vast majority of laboratory studies on animals have focused on ventricular fibrillation (VF) and not on cardiac arrest (CA) resulting from asphyxia. The aim of this study was to develop a clinically relevant animal model in Landrace/Large-White swine of asphyxial CA resuscitated using the European Resuscitation Cou...
15,263
The magnetic navigation system allows safety and high efficacy for ablation of arrhythmias.
We aimed to evaluate the safety and long-term efficacy of the magnetic navigation system (MNS) in a large number of patients. The MNS has the potential for improving safety and efficacy based on atraumatic catheter design and superior navigation capabilities.</AbstractText>In this study, 610 consecutive patients underw...
15,264
Atrioventricular nodal ablation versus antiarrhythmic drugs after permanent pacemaker implantation for bradycardia-tachycardia syndrome.
Patients often require antiarrhythmic drugs to control tachycardia after permanent pacemaker implantation (PMI) for bradycardia-tachycardia syndrome. We compared atrioventricular nodal ablation (AVNA) to antiarrhythmic drugs after PMI for bradycardia-tachycardia syndrome. Twenty-eight symptomatic patients with bradycar...
15,265
Disassociation between left ventricular mechanical and electrical properties in ischemic rat heart after G-CSF treatment.
The effect of granulocyte colony-stimulating factor (G-CSF) on post-infarct ventricular remodeling remains controversial. We hypothesized that the timing of G-CSF administration after myocardial ischemia plays an important role in determining its efficacy.</AbstractText>Rat myocardial ischemia was induced by 60 min cor...
15,266
[Association between left ventricular wall motion abnormalities and ventricular arrhythmia in the indeterminate form of Chagas disease].
Chagas' disease can lead to severe and potentially lethal damage of cardiac function. Thus, the identification of cardiac abnormalities in patients presenting the indeterminate form (IF) can be important for risk stratification. This paper aimed to demonstrate whether IF chagasic patients who presented wall motion abno...
15,267
Uric acid levels and atrial fibrillation in hypertensive patients.
Uric acid (UA) is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. The objective of this observational study was to investigate the association between UA levels and AF in hypertensive patients....
15,268
Isolated coronary artery bypass grafting in obese individuals: a propensity matched analysis of outcomes.
There is conflicting data regarding the impact of obesity on morbidity and mortality in patients undergoing isolated coronary artery bypass grafting (CABG).</AbstractText>Retrospective cohort analysis of patients who underwent CABG from January 1, 1995, through July 31, 2010 was performed. Patients were classified as o...
15,269
The effect of cardiac sympathetic denervation through bilateral stellate ganglionectomy on electrical properties of the heart.
The role of the cardiac sympathetic nerve activity in various cardiac diseases is typically evaluated using &#x3b2;-adrenergic receptor antagonists. However, these antagonists induce global denervation effects not only in the cardiovascular system, but also in the brain and kidney. The objective of this study was to de...
15,270
Left ventricular inflow tract obstruction secondary to a myxoma in a dog.
This is the first description of a left ventricular inflow tract obstruction secondary to a myxoma in a dog. A 4 yr old, male fox terrier presented with a 1 mo history of cough and exercise intolerance. Expiratory dyspnea, pulmonary crackles, irregular cardiac rhythm, and a grade 4/6 pansystolic cardiac murmur over the...
15,271
The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.
Risk-stratifying heart failure patients for primary prevention implantable cardioverter-defibrillators (ICDs) remains a challenge, especially for blacks, who have an increased incidence of sudden cardiac death but have been underrepresented in clinical trials. We hypothesized that the S1103Y cardiac sodium channel SCN5...
15,272
Restrictive left ventricular filling pattern and risk of new-onset atrial fibrillation after acute myocardial infarction.
Mechanisms for atrial arrhythmias that occur in the context of acute myocardial infarction (AMI) have not been well characterized. AMI often leads to alterations in left ventricular (LV) filling dynamics, which may result in advanced diastolic dysfunction. Diastolic dysfunction may produce increased left atrial (LA) pr...
15,273
Out-of-hospital cardiac arrests in young adults in Melbourne, Australia.
Characteristics and outcomes of out-of-hospital cardiac arrest (OHCA) in young adults are not well described in Australia.</AbstractText>A 10-year retrospective case review of all OHCA in young adults (aged 16-39) and not witnessed by EMS, was performed using data from the Victorian Ambulance Cardiac Arrest Registry (V...
15,274
A 61-year-old patient with activity-related wide complex tachycardia.
<b>Ann Noninvasive Electrocardiol 2011;16(2):208&#x2013;212</b>
15,275
Clinical aspects of the early repolarization syndrome: a 2011 update.
Recent studies suggest that the electrocardiographic (ECG) finding of J-point ST-elevation, the early repolarization syndrome, is not as benign as earlier believed. Three important articles published in 2008/2009 suggest that this finding in the inferolateral leads of the ECG may be representing a risk for subsequent v...
15,276
The evaluation and management of electrical storm.
Electrical storm is an increasingly common and life-threatening syndrome that is defined by 3 or more sustained episodes of ventricular tachycardia, ventricular fibrillation, or appropriate shocks from an implantable cardioverter-defibrillator within 24 hours. The clinical presentation can be dramatic. Electrical storm...
15,277
KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.
Brugada syndrome (BrS) has a significantly higher incidence among the male sex. Among genes coding ion channels and their modulatory proteins, KCNE5 (KCNE1L) is located in the X chromosome and encodes an auxiliary &#x3b2;-subunit for K channels. KCNE5 has been shown to modify the transient outward current (I(to)), whic...
15,278
Utility of the ventricular fibrillation waveform to predict a return of spontaneous circulation and distinguish acute from post myocardial infarction or normal Swine in ventricular fibrillation cardiac arrest.
In cardiac arrest, the ventricular fibrillation (VF) waveform, particularly amplitude spectral area (AMSA) and slope, predicts the return of spontaneous circulation (ROSC), but it is unknown whether the predictive utility differs in an acute myocardial infarction (MI), prior MI, or normal myocardium and if the waveform...
15,279
Gaps in the ablation line as a potential cause of recovery from electrical isolation and their visualization using MRI.
Ablation has become an important tool in treating atrial fibrillation and ventricular tachycardia, yet the recurrence rates remain high. It is well established that ablation lines can be discontinuous and that conduction through the gaps in ablation lines can be affected by tissue heating. In this study, we looked at t...
15,280
[Ventricular fibrillation with tolonium chloride: axillary brachial plexus anesthesia led to cessation of circulation].
A 22-year-old patient underwent surgery for a glass wound incision of the hand and anesthesia was carried out using an axillary brachial plexus block with prilocaine. Following surgery the patient developed methemoglobinemia which was treated with tolonium chloride. After administration of the drug the sinus rhythm cha...
15,281
Spectral methods to distinguish ventricular fibrillation from artefact in implantable cardioverter-defibrillators.
Despite the proven benefit of implantable cardioverter-defibrillators (ICDs), inappropriate shocks remain a significant problem. Recent trends have shown an increased incidence of lead failure and an increased exposure of devices to extreme electromagnetic interference environments.</AbstractText>The goal of the curren...
15,282
Low-level right vagal stimulation: anticholinergic and antiadrenergic effects.
We sought to extend the use of low-level vagal stimulation by applying it only to the right vagus nerve (LL-RVS) to suppress atrial fibrillation (AF).</AbstractText>In 10 pentobarbital anesthetized dogs, LL-RVS (20 Hz, 0.1 ms pulse width) was delivered to the right vagal trunk via wire electrodes at voltages 50% below ...
15,283
Pretreatment of BAPTA-AM suppresses the genesis of repetitive endocardial focal discharges and pacing-induced ventricular arrhythmia during global ischemia.
In isolated rabbit hearts, repetitive endocardial focal discharges (REFDs) were consistently observed during ventricular fibrillation (VF) with prolonged (&gt;5 minutes) global ischemia (GI). We hypothesized that BAPTA-AM, a calcium chelator, can suppress these REFDs.</AbstractText>Using a two-camera optical mapping sy...
15,284
Left atrial mechanical responses to right ventricular pacing in heart failure patients: implications for atrial fibrillation.
RV pacing (RVP), even with preserved atrioventricular (AV) synchrony, may lead to left atrial (LA) enlargement and atrial fibrillation. However, inciting events are unknown. We hypothesized that RVP acutely impairs LA function by mechanisms affecting atrial contraction and/or ventricular diastole.</AbstractText>LA func...
15,285
Potential risk of provisional stenting in left main coronary artery bifurcation in multivessel-related acute coronary syndrome.
We present a case of an elderly man suffering from an acute coronary syndrome (ACS) with preshock vital signs and remarkable ST-T wave depression in leads V4-V6, and ST elevation in lead aVR. Coronary angiography showed total occlusion of the right coronary artery (RCA) and impending occlusion in the distal left main c...
15,286
Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.
The Kv11.1 (hERG) K+ channel plays a fundamental role in cardiac repolarization. Missense mutations in KCNH2, the gene encoding Kv11.1, cause long QT syndrome (LQTS) and frequently cause channel trafficking-deficiencies. This study characterized the properties of a novel KCNH2 mutation discovered in a LQT2 patient resu...
15,287
Scroll-wave dynamics in human cardiac tissue: lessons from a mathematical model with inhomogeneities and fiber architecture.
Cardiac arrhythmias, such as ventricular tachycardia (VT) and ventricular fibrillation (VF), are among the leading causes of death in the industrialized world. These are associated with the formation of spiral and scroll waves of electrical activation in cardiac tissue; single spiral and scroll waves are believed to be...
15,288
Prolonged QRS duration in lead V2 and risk of life-threatening ventricular Arrhythmia in patients with Brugada syndrome.
Brugada syndrome is an inherited disorder that predisposes some patients to sudden cardiac death. It is not well established which Brugada syndrome patients are at risk of life-threatening arrhythmias. We investigated whether standard 12-lead electrocardiograms (ECG) can identify such patients. The subjects were 35 men...
15,289
Variable effects of high-dose adrenaline relative to standard-dose adrenaline on resuscitation outcomes according to cardiac arrest duration.
Adjustment of adrenaline (epinephrine) dosage according to cardiac arrest (CA) duration, rather than administering the same dose, may theoretically improve resuscitation outcomes. We evaluated variable effects of high-dose adrenaline (HDA) relative to standard-dose adrenaline (SDA) on resuscitation outcomes according t...
15,290
Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation.
Coagulopathy is often present after resuscitation from cardiac arrest but plays an undefined role in the post cardiac arrest syndrome. The aim of this study was to characterize coagulation changes during cardiac arrest and post-resuscitation care in order to direct further focused study.</AbstractText>Ventricular fibri...
15,291
Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation.
Genomewide association studies have reproducibly identified rs2200733T on chromosome 4q25 as a risk factor for the most common sustained arrhythmia, atrial fibrillation (AF). The biologic basis for cardiac electrical instability conferred by this noncoding variant is unknown. The aim of this study was to investigate po...
15,292
Relation of ventricular tachycardia/fibrillation to beta-blocker dose maximization guided by pacing mode analysis in nonpacemaker-dependent patients with implantable cardioverter-defibrillator.
We hypothesized that uptitration of &#x3b2; blockade and adjustment of pacing parameters to achieve a prevalence of single chamber atrial inhibited rate-responsive (AAIR) pacing in patients with dual-chamber implantable cardioverter--defibrillators (ICDs) would result in maximization of &#x3b2;-blocker dosage and thus ...
15,293
Exercise related cardiac arrest in amateur athletes on the tennis court.
The aim of this study was to study exercise-related cardiac arrests on the tennis court and investigate the impact of early initiation of cardiopulmonary resuscitation on survival rate and outcome.</AbstractText>This study was based on the cardiac arrest registry of the Department of Emergency Medicine at the General H...
15,294
Does early postresuscitation stress hyperglycemia affect 72-hour neurologic outcome? Preliminary observations in the Swine model.
Hyperglycemia is common in the early period following resuscitation from cardiac arrest and has been shown to be a predictor of neurologic outcome in retrospective studies.</AbstractText>To evaluate neurologic outcome and early postarrest hyperglycemia in a swine cardiac arrest model.</AbstractText>Electrically induced...
15,295
Additional coronary sinus defibrillation lead with a right pectoral ICD and high DFT : a case report.
We report the case of a 63-year-old man with ischemic cardiomyopathy having an implantable cardioverter defibrillator (ICD) implanted for repeated ventricular tachycardia (VT). After several revisions of the ICD lead, a thrombosis of the left venous system was diagnosed. A right pectoral ICD device was implanted, and a...
15,296
Genetics of sudden death: focus on inherited channelopathies.
Since the discovery of the genetic bases of the long QT syndrome, several new genetically mediated arrhythmias have been described, defining a new group of syndromes, called inherited arrhythmogenic diseases. This allowed clarifying the substrate of several cases of juvenile sudden death, previously defined as 'idiopat...
15,297
Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts.
Selective glycolytic inhibition (GI) promotes electromechanical alternans and triggered beats in isolated cardiac myocytes. We sought to determine whether GI promotes triggered activity by early afterdepolarization (EAD) or delayed afterdepolarizations in intact hearts isolated from adult and aged rats. Dual voltage an...
15,298
Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers.
AIMS: Hypertrophic cardiomyopathy (HCM) is a frequent cause of sudden cardiac death (SCD) due to exercise-related ventricular arrhythmias (ERVA); however the pathological substrate is uncertain. The aim was to determine the prevalence of ERVA and their relation with fibrosis as determined by cardiac magnetic resonance ...
15,299
Archetype, adaptation and the mammalian heart.
Forty years ago, we started our quest for 'The Holy Grail' of understanding ventricular rate control and rhythm in atrial fibrillation (AF). We therefore studied the morphology and function of a wide range of mammalian hearts. From mouse to whale, we found that all hearts show similar structural and functional characte...