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2,327,200 | Erosion of a right ventricular pacer lead into the left chest wall. | Erosion of a pacer lead into the chest wall may result in pericardial effusion with cardiac tamponade. Free rupture into the pleura or mediastinum can result in hypotension and cardiac arrest.</AbstractText>We report a unique case of a right ventricular pacer lead which eroded through the right ventricle into the left ... |
2,327,201 | Spontaneous external rupture of hydrocephalus after fontanelle closure: a case report and review of literature. | We report a 2-year-old child with congenital hydrocephalus who presented with a frontal meningocoele due to ventriculo-subgaleal fistula secondary to hydrocephalus (internal rupture), which gradually ruptured spontaneously through the skin. This case is unique given its association with occipital encephalocele and is o... |
2,327,202 | Age-associated decline in septum neuronal activation during spatial learning in homing pigeons (Columba livia). | The relationship between hippocampal aging and spatial-cognitive decline in birds has recently been investigated. However, like its mammalian counterpart, the avian hippocampus does not work in isolation and its relationship to the septum is of particular interest. The current study aimed to investigate the effects of ... |
2,327,203 | Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. | Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for cooperative binding to sequence-paired sites (SPS) located near many ... |
2,327,204 | Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. | Neurological complications are common in patients with COVID-19. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect brain cells and impact their function is not well understood. Here, we investigated the... |
2,327,205 | Monodisperse versus Polydisperse Ultrasound Contrast Agents: In Vivo Sensitivity and safety in Rat and Pig. | Recent advances in the field of monodisperse microbubble synthesis by flow focusing allow for the production of foam-free, highly concentrated and monodisperse lipid-coated microbubble suspensions. It has been found that in vitro, such monodisperse ultrasound contrast agents (UCAs) improve the sensitivity of contrast-e... |
2,327,206 | Serial ultrastructural evaluation of myocardial ischemic injury after infusion of del Nido cardioplegia in the human heart. | The safe ischemic time after a single-dose del Nido cardioplegia (DNC) infusion has not yet been established. This study evaluated the progression of myocardial ischemic injury to establish the safe ischemic time after a single-dose DNC infusion in the human heart using a transmission electron microscope.</AbstractText... |
2,327,207 | Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium. | The choroid plexus plays a central role in the regulation of the microenvironment of the central nervous system by secreting the majority of the cerebrospinal fluid and controlling its composition, despite that it only represents approximately 1% of the total brain weight. In addition to a variety of transporter and ch... |
2,327,208 | Clinical and Imaging Features of Primary Cardiac Angiosarcoma.<ELocationID EIdType="pii" ValidYN="Y">776</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/diagnostics10100776</ELocationID><Abstract><AbstractText>This study aims to explore computed tomography (CT) and magnetic resonance imaging (MRI) features ... | This study aims to explore computed tomography (CT) and magnetic resonance imaging (MRI) features of patients diagnosed with primary cardiac angiosarcoma. The study involved the analysis of 12 patients diagnosed with primary cardiac angiosarcoma who underwent non-contrast (8/12) or contrast-enhanced CT (10/12) or MRI (... |
2,327,209 | Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish. | Dopamine (DA)-producing neurons are critically involved in the production of motor behaviors in multiple circuits that are conserved from basal vertebrates to mammals. Although there is increasing evidence that DA neurons in the hypothalamus play a locomotor role, their precise contributions to behavior and the circuit... |
2,327,210 | Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment. | Central innate immunity assists time-dependent neurodevelopment by recruiting and interacting with peripheral immune cells. Microglia are the major player of central innate immunity integrating peripheral signals arising from the circumventricular regions lacking the blood-brain barrier (BBB), via neural afferent pathw... |
2,327,211 | A latent lineage potential in resident neural stem cells enables spinal cord repair. | Injuries to the central nervous system (CNS) are inefficiently repaired. Resident neural stem cells manifest a limited contribution to cell replacement. We have uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord. Integrating multimodal si... |
2,327,212 | Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model. | Zebrafish (<i>Danio rerio</i>) larvae have gained attention as a valid model to study in vivo drug metabolism and to predict human metabolism. The microinjection of compounds, oligonucleotides, or pathogens into zebrafish embryos at an early developmental stage is a well-established technique. Here, we investigated the... |
2,327,213 | Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone. | Neural progestin receptors (PR) function in reproduction, neural development, neuroprotection, learning, memory and the anxiety response. In the absence of progestins, PR can be activated by dopamine (DA) in the rodent hypothalamus to elicit female sexual behaviour. The present study investigated mechanisms of DA activ... |
2,327,214 | Screening of potential genes and transcription factors involved in post-radiation cognitive dysfunction in mice via bioinformatics. | This study aimed to identify potential genes and transcription factors involved in postradiation cognitive dysfunction using bioinformatics analysis.</AbstractText>Bioinformatics tools were used to identify differentially expressed mRNAs between postradiation cognitive dysfunctional and control tissue. The GSE115735 da... |
2,327,215 | The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model. | Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system with symptoms such as neuroinflammation, astrocytosis, microgliosis, and axonal degeneration. Mesenchymal stem cells (MSCs) with their immunomodulation, differentiation, and neuroprotection abilities can influence the remyelinat... |
2,327,216 | Haptic-based virtual reality simulator for lateral ventricle puncture operation. | The implementation of lateral ventricle puncture (LVP) operation is challenging due to the complex anatomy structure of human brains. Surgical simulator has been proved to be effective in surgical training. However, few works consider the integration of visual and haptic feedback.</AbstractText>Aim at achieving a reali... |
2,327,217 | Breast size and dose to cardiac substructures in adjuvant three-dimensional conformal radiotherapy compared to tangential intensity modulated radiotherapy. | Background The aim of the study was to quantify planned doses to the heart and specific cardiac substructures in free-breathing adjuvant three-dimensional radiation therapy (3D-CRT) and tangential intensity modulated radiotherapy (t-IMRT) for left-sided node-negative breast cancer, and to assess the differences in plan... |
2,327,218 | Transcortical endoportal subchoroidal endoscope-assisted approach to the third ventricle: from virtual reality to anatomical laboratory. | Surgical approaches to the third ventricle (TV) have always represented a technical challenge in neurosurgery. Virtual reality (VR) is attaining increasing relevance in training programs and preoperative planning. The aim of this study is to demonstrate the worthwhile mutual contribution of VR simulations and specimen ... |
2,327,219 | A novel hypomorphic allele of <i>Spag17</i> causes primary ciliary dyskinesia phenotypes in mice. | Primary ciliary dyskinesia (PCD) is a human condition of dysfunctional motile cilia characterized by recurrent lung infection, infertility, organ laterality defects and partially penetrant hydrocephalus. We recovered a mouse mutant from a forward genetic screen that developed many of the hallmark phenotypes of PCD. Who... |
2,327,220 | Surgical Anatomy Applied to the Resection of Craniopharyngiomas: Anatomic Compartments and Surgical Classifications. | Resective surgery remains the main treatment option for most patients with craniopharyngiomas. Understanding of the microsurgical anatomy of the sella and suprasellar region and its relationship with these tumors is necessary to achieve effective surgical treatment and minimize complications. In this article, we review... |
2,327,221 | Technical Performance Score: A Predictor of Outcomes After the Norwood Procedure. | The Technical Performance Score (TPS) can predict outcomes after congenital cardiac surgery. We sought to validate TPS as a predictor of both short- and long-term outcomes of the Norwood procedure.</AbstractText>We conducted a retrospective review of patients who underwent the Norwood procedure from 1997 to 2017. We as... |
2,327,222 | Response to: Next-level examination of His-optimized cardiac resynchronization therapy by noninvasive electrocardiographic activation mapping.<Pagination><StartPage>3064</StartPage><MedlinePgn>3064</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jce.14734</ELocationID><AuthorList CompleteYN="Y">... | Based on twice transverse aortic constrictions (TACs) in mice, it is proved that myocardial hypertrophic preconditioning (MHP) could attenuate cardiomyocyte hypertrophy and slow down progression to heart failure. For novices, however, the MHP model is usually quite difficult to establish because of the technical obstac... |
2,327,223 | Post-operative intracranial gas migration with optic nerve infiltration and atrophy following retinal detachment repair. | To report a patient with post-operative gas migration into the optic nerve and lateral ventricles after retinal detachment repair.</AbstractText>A 78-year-old pseudophakic man developed a temporal visual field cut in his non-operative, right eye 3 weeks after repair of a recurrent, shallow, macula-involving retinal det... |
2,327,224 | The Cardiac Syndecan-2 Interactome. | The extracellular matrix (ECM) is important in cardiac remodeling and syndecans have gained increased interest in this process due to their ability to convert changes in the ECM to cell signaling. In particular, syndecan-4 has been shown to be important for cardiac remodeling, whereas the role of its close relative syn... |
2,327,225 | The role of Hippo signaling pathway in physiological cardiac hypertrophy. | <i><b>Introduction:</b></i> The role of Hippo signaling pathway, which was identified by genetic studies as a key regulator for tissue growth and organ size, in promoting physiological cardiac hypertrophy has not been investigated. <i><b>Methods:</b></i> Fourteen male Wistar rats were randomly assigned to the exercise ... |
2,327,226 | Aggressive intracerebral tuberculoma in a 1-year-old child: A case report with literature review. | The incidence of central nervous system tuberculosis is a rare entity that accounts about 1% of all tuberculosis and remains a major health problem in developing countries. We report a case of 1-year-old baby boy who presented with a three-week history of vomiting, seizure and progressive right-sided weakness. Brain ma... |
2,327,227 | Opening and closure of intraventricular neuroendoscopic procedures in infants under 1 year of age: institutional technique, case series and review of the literature. | Intraventricular neuroendoscopic techniques, particularly third ventriculostomy, are employed increasingly in the management of infantile hydrocephalus. However, surgical access to the ventricular cavities is associated with a risk of post-operative cerebrospinal fluid (CSF) leak. Here, we describe a structured, multi-... |
2,327,228 | Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case. | Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children.</AbstractText>We report a systematic... |
2,327,229 | Neural basis of unfamiliar conspecific recognition in domestic chicks (Gallus Gallus domesticus). | Domestic chickens are able to distinguish familiar from unfamiliar conspecifics, however the neuronal mechanisms mediating this behaviour are almost unknown. Moreover, the lateralisation of chicks' social recognition has only been investigated at the behavioural level, but not at the neural level. The aim of the presen... |
2,327,230 | Bipedicled Vocal Fold Mucosal Flap: An Experimental Study. | To determine the dimensions of mucosal defects that can be covered by a bipedicled vocal fold mucosal flap.</AbstractText>We used 20 adults human larynges (10 of each gender) excised from cadavers, divided into 2 groups of 10 larynges (5 of each gender) each. In one group (the normal flap group), we created the largest... |
2,327,231 | Success and complication rates of endoscopic third ventriculostomy for tuberculous meningitis: a systematic review and meta-analysis. | Because ventriculoperitoneal shunt (VPS) insertion for patients with hydrocephalus from tuberculous meningitis (TBM) can be complicated by shunt infection and malfunction, endoscopic third ventriculostomy (ETV) has been proposed as an alternative. The aim of this review was to determine the success, technical failure, ... |
2,327,232 | Anorexia as the first clinical manifestation of von Hippel-Lindau syndrome. | Hemangioblastomas (HBs) of the brain may present without neurological symptoms over a long period of time due to their benignity and slow growth. We herein present the case of a female patient who developed a HB of the fourth ventricle presenting only with severe weight loss and anorexia. The patient was screened for m... |
2,327,233 | Cortical Thinning and Ventricle Enlargement in Neuromyelitis Optica Spectrum Disorders. | <b>Background:</b> In neuromyelitis optica spectrum disorders (NMOSDs), inflammation is not the sole driver of accumulation of disability; neurodegeneration is another important pathological process. We aim to explore different patterns of cortical atrophy and ventricular enlargement in NMOSD. <b>Methods:</b> We retros... |
2,327,234 | Characterization of the hypoxia-inducible factor-1 pathway in hearts of Antarctic notothenioid fishes. | The ability of Antarctic notothenioid fishes to mount a robust molecular response to hypoxia is largely unknown. The transcription factor, hypoxia-inducible factor-1 (HIF-1), a heterodimer of HIF-1α and HIF-1β subunits, is the master regulator of oxygen homeostasis in most metazoans. We sought to determine ... |
2,327,235 | Assessment of Structure, Function, and Rhythm of the Heart with Echocardiography and Electrocardiography in Adolescent Swimmers.<Pagination><StartPage>182</StartPage><EndPage>188</EndPage><MedlinePgn>182-188</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00246-020-02469-x</ELocationID><Abstrac... | The aim of this study was to evaluate the cardiac parameters by using electrocardiography and echocardiography in adolescent swimmers. Twenty-two adolescent swimmers and 22 gender- and age-matched sedentary controls admitted to our center between November 2018 and May 2019 were included in this study. In addition to de... |
2,327,236 | Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease. | Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the presence of amyloid-β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels in the brain and protected against cognitive deficits in amyloid precursor protein/presenilin 1(APP/PS1) mice. However, the und... |
2,327,237 | Assessment of left ventricular contractile functions in inflammatory bowel disease according to disease activity.<Pagination><StartPage>629</StartPage><EndPage>638</EndPage><MedlinePgn>629-638</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/1751-2980.12943</ELocationID><Abstract><AbstractText La... | The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining tech... |
2,327,238 | Collision Tumor in the Pituitary, Concurrent Pituitary Adenoma, and Craniopharyngioma. | Collision tumors are two independent, distinct tumors occupying the same anatomical space. This case presents a pituitary adenoma-craniopharyngioma collision tumor presenting with hemianopsia. A 60-year-old with a past history of a nonsecretory pituitary adenoma presented with progressive headaches, bitemporal hemianop... |
2,327,239 | Reply to in Response to Guidewire Entrapped in the Right Ventricle. | <b>How to cite this article:</b> Verma A, Jaiswal S, Vishen A, Sheikh WR, Haldar M, Ahuja R, <i>et al.</i> Reply to in Response to Guidewire Entrapped in the Right Ventricle. Indian J Crit Care Med 2020;24(7):608. |
2,327,240 | In Response to Guidewire Entrapped in the Right Ventricle: A Rare Complication of Hemodialysis Catheter Insertion. | Verma et al. meticulously prevented the further complications once they recognize the entrapped guidewire in the right ventricle. Authors were very correct to mention overzealous insertion of the guidewire without watching the monitor, which may lead to such complications; however, every time monitor is not available f... |
2,327,241 | Normal Age- and Sex-Related Values of the Optic Nerve Sheath Diameter and Its Dependency on Position and Positive End-Expiratory Pressure. | Optic nerve sheath diameter (ONSD) sonography is a reliable method for evaluation of intracranial pressure, yet there is a lack of reliable normal values. In the study described here, we established normal ONSD values in three different age groups and both sexes. One hundred eighty-seven volunteers without central nerv... |
2,327,242 | Microstructural Predictors of Cognitive Impairment in Cerebral Small Vessel Disease and the Conditions of Their Formation. | Cerebral small vessel disease (CSVD) is the leading cause of vascular and mixed degenerative cognitive impairment (CI). The variability in the rate of progression of CSVD justifies the search for sensitive predictors of CI.</AbstractText>A total of 74 patients (48 women, average age 60.6 ± 6.9 years) with CSVD and... |
2,327,243 | Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. | The choroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop imaging tools to interrogate these functions in adult lateral ventricle ChP in whole-mount explants and in awake mice. By imaging epithelial cells in int... |
2,327,244 | Vitamin E is necessary for zebrafish nervous system development. | Vitamin E (VitE) deficiency results in embryonic lethality. Knockdown of the gene ttpa encoding for the VitE regulatory protein [α-tocopherol transfer protein (α-TTP)] in zebrafish embryos causes death within 24 h post-fertilization (hpf). To test the hypothesis that VitE, not just α-TTP, is nece... |
2,327,245 | Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus. | Accumulation of amyloid-beta (Aβ) in the brain is thought to derive from the impairment of Aβ clearance mechanisms rather than from its overproduction, which consequently contributes to the development of Alzheimer's disease. The choroid plexus epithelial cells constitute an important clearance route for A&... |
2,327,246 | High-quality Digital 3D Reconstruction of Microscopic Findings in Forensic Pathology: The Terminal Pathway of a Heart Stab Wound. | High-quality digital three-dimensional (3D) reconstructions of microscopic findings have been used in anatomical and histopathologic research, but their use in forensic pathology may also be of interest. This paper presents an application of these methods to better characterize the pathway of a stab wound of the anteri... |
2,327,247 | Effects of allopregnanolone on central reproductive functions in sheep under natural and stressful conditions. | Reproductive functions may be affected by internal and external factors that are integrated in the central nervous system (CNS). Stressful stimuli induce the neuroendocrine response of the hypothalamic-pituitary-adrenal axis, as well as the synthesis of the neurosteroid allopregnanolone (AL) in the brain. This study te... |
2,327,248 | Regional Lung Perfusion Analysis in Experimental ARDS by Electrical Impedance and Computed Tomography. | Electrical impedance tomography is clinically used to trace ventilation related changes in electrical conductivity of lung tissue. Estimating regional pulmonary perfusion using electrical impedance tomography is still a matter of research. To support clinical decision making, reliable bedside information of pulmonary p... |
2,327,249 | Endoscopic third ventriculostomy for treatment of tonsillar descent with hydrocephalus: CSF flow dynamics and treatment strategies. | To explore the role of cerebrospinal fluid (CSF) flow dynamics and develop treatment strategies involving endoscopic surgery for tonsillar descent with hydrocephalus.</AbstractText>This study included 15 patients with tonsillar descent with hydrocephalus. All patients underwent cine-magnetic resonance imaging (MRI) pre... |
2,327,250 | New Polish prototypes of 4- and 8-mm-tip nonirrigated radiofrequency ablation catheters: an in vitro study.<Pagination><StartPage>1142</StartPage><EndPage>1147</EndPage><MedlinePgn>1142-1147</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.33963/KP.15605</ELocationID><Abstract><AbstractText Label="BAC... | The transient receptor potential vanilloid type 1 (TRPV1), a thermosensitive cation channel, is known to trigger pain in the peripheral nerves. In addition to its peripheral function, its involvement in brain functions has also been suggested. Resiniferatoxin (RTX), an ultrapotent TRPV1 agonist, has been known to induc... |
2,327,251 | An adult case of diffuse midline glioma with H3 K27M mutation. | Cartilaginous metaplasia is rare in primary central nervous system (CNS) neoplasms and has not been described in the histone 3 (H3) gene (H3) with a substitution of lysine to methionine (H3 K27M mutant) diffuse midline glioma before. Here, we report a case of H3 K27M mutant diffuse midline glioma with cartilaginous met... |
2,327,252 | Finders Keepers: A Case of the Rogue Pacing Wire. | We report a middle-aged woman with frequent episodes of pre-syncope due to complete heart block. She had no previous history of anticoagulation or steroid therapy, and underwent temporary pacemaker insertion. In spite of only mild symptoms, she was found to have a right ventricle perforation on CT. After placement of p... |
2,327,253 | Gastrointestinal neuroendocrine tumors in Fontan patients. | The Fontan procedure used for palliation of single ventricle physiology is associated with multisystemic morbidity. With improving survival and increased use of surveillance imaging in this patient population, long-term complications associated with Fontan circuits are commonly encountered by radiologists. One interest... |
2,327,254 | Strengths and weaknesses of frontal versus occipital ventriculoperitoneal shunt placement: A systematic review. | Excessive accumulation of cerebrospinal fluid within the brain ventricles is called hydrocephalus, which results in increased intracranial pressure preventing brain growth or causing damage to intracranial structures due to raised intracranial pressure. One of the most common treatment options for this pathology includ... |
2,327,255 | Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits. | Hippocampal circuitry is continuously modified by integration of adult-born dentate granule cells (DGCs). Prior work has shown that enhancing adult hippocampal neurogenesis decreases interference or overlap or conflict between ensembles of similar contexts and promotes discrimination of a shock-associated context from ... |
2,327,256 | Transcription factor expression defines subclasses of developing projection neurons highly similar to single-cell RNA-seq subtypes. | We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex. Such categorization is a first step toward understanding how diversification relates to function. All cortical projection neurons arise from a uniform pool of progenitor cells that lines the ventricles of the forebrain. It is... |
2,327,257 | Somatostatin 1.1 contributes to the innate exploration of zebrafish larva. | Pharmacological experiments indicate that neuropeptides can effectively tune neuronal activity and modulate locomotor output patterns. However, their functions in shaping innate locomotion often remain elusive. For example, somatostatin has been previously shown to induce locomotion when injected in the brain ventricle... |
2,327,258 | Endoscopic intervention for intraventricular neurocysticercal cyst: Challenges and outcome analysis from a single institute experience. | Endoscopic intervention is presently proposed as standard approach for the treatment of Intraventricular neurocysticercal cyst (IVNCC) as it helps to retrieve the cyst as well as CSF diversion. We present our series of 61 patients with IVNCC managed by endoscopic intervention and analyze the outcome.</AbstractText>A re... |
2,327,259 | Pediatric Suprasellar Germ Cell Tumors: A Clinical and Radiographic Review of Solitary vs. Bifocal Tumors and Its Therapeutic Implications. | Suprasellar germ cell tumors (S-GCTs) are rare, presenting in either solitary or multifocal fashion. In this study, we retrospectively examine 22 solitary S-GCTs and 20 bifocal germ cell tumors (GCTs) over a 30-year period and demonstrate clinical, radiographic, and prognostic differences between the two groups with th... |
2,327,260 | Adeno-associated virus serotype 1-based gene therapy for FTD caused by GRN mutations. | Dominant loss-of-function mutations in the gene encoding the lysosomal protein, progranulin, cause 5-10% of frontotemporal dementia cases. As progranulin undergoes secretion and endocytosis, a small number of progranulin-expressing cells can potentially supply the protein to the entire central nervous system. Thus, gen... |
2,327,261 | The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway. | In the adult hypothalamus, the neuronal precursor role is attributed to the radial glia-like cells that line the third-ventricle (3V) wall called tanycytes. Under nutritional cues, including hypercaloric diets, tanycytes proliferate and differentiate into mature neurons that moderate body weight, suggesting that hypoth... |
2,327,262 | Third ventricle hydatid cyst: A rare case report and review of the literature. | A primary intraventricular hydatid cyst is a very rare phenomenon, which is mostly located in the lateral ventricle. To the best of our knowledge, only two cases of third ventricle hydatid cyst have been reported. Herein, we present a very rare case of third ventricle hydatid cyst in a four- year-old boy with nausea, v... |
2,327,263 | Mapping Calcium Dynamics in the Heart of Zebrafish Embryos with Ratiometric Genetically Encoded Calcium Indicators. | Zebrafish embryos have been proposed as a cost-effective vertebrate model to study heart function. Many fluorescent genetically encoded Ca<sup>2+</sup> indicators (GECIs) have been developed, but those with ratiometric readout seem more appropriate to image a moving organ such as the heart. Four ratiometric GECIs based... |
2,327,264 | The association between MRI brain volumes and computerized cognitive scores of people with multiple sclerosis. | Computerized cognitive assessment facilitates the incorporation of multi-domain cognitive monitoring into routine clinical care. The predictive validity of computerized cognitive assessment among people with multiple sclerosis (PwMS) has scarcely been investigated.</AbstractText>To explore the associations between brai... |
2,327,265 | Impact of bi-planar localization of the tricuspid valve on the evaluation of right ventricular functional parameters in the short axis plane.<Pagination><StartPage>2255</StartPage><EndPage>2263</EndPage><MedlinePgn>2255-2263</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10554-020-01941-2</ELo... | Primary objective was to evaluate by cardiac MRI the accuracy of right ventricular stroke volume (RVSV) measurement in the short-axis (SA) plane with cross-referencing of the tricuspid plane. 2D phase-contrast measurement at the main pulmonary artery (PSV) was the reference. Secondary objective was to analyze the repro... |
2,327,266 | A Rare Case of Choroid Plexus Papilloma of the Third Ventricle in an Adult. | Colloid cysts are the commonest masses of the third ventricle. Third ventricle neoplasms are uncommon. They include tumors arising from the choroid plexus (papillomas, carcinomas), tumors arising from other than the choroid plexus (ependymomas, meningiomas), metastases, and lymphoma. Choroid plexus tumors usually occur... |
2,327,267 | Diagnose and treatment of traumatic pleural-subarachnoid fistula in children: A case report and systematic review. | Pleural-subarachnoid fistula (PSF) is a rare disease that is difficult to diagnose and treat. Secondary intracranial hypertension and the treatment are seldom mentioned previously among PSF.</AbstractText>A 1-year-old boy diagnosed PSF developed into secondary intracranial hypertension after conservative treatment. He ... |
2,327,268 | Diagnostic evaluation of fatal Balamuthia mandrillaris meningoencephalitis in a captive Bornean orangutan (Pongo pygmaeus) with identification of potential environmental source and evidence of chronic exposure. | A female Bornean orangutan (Pongo pygmaeus) aged 11 years and 6 months was examined by veterinarians after caretakers observed lethargy and facial grimacing. Within 72 h the primate had left-sided hemiparesis that worsened over the next week. An MRI revealed a focal right-sided cerebral mass suspected to be a neop... |
2,327,269 | DSCAM regulates delamination of neurons in the developing midbrain. | For normal neurogenesis and circuit formation, delamination of differentiating neurons from the proliferative zone must be precisely controlled; however, the regulatory mechanisms underlying cell attachment are poorly understood. Here, we show that Down syndrome cell adhesion molecule (DSCAM) controls neuronal delamina... |
2,327,270 | Brain ventricular enlargement in human and murine acute intermittent porphyria. | The morphological changes that occur in the central nervous system of patients with severe acute intermittent porphyria (AIP) have not yet been clearly established. The aim of this work was to analyze brain involvement in patients with severe AIP without epileptic seizures or clinical posterior reversible encephalopath... |
2,327,271 | Pediatric hydrocephalus outcomes in Lusaka, Zambia. | Hydrocephalus is a global disease that disproportionally impacts low- and middle-income countries. Limited data are available from sub-Saharan Africa. This study aims to be the first to describe pediatric hydrocephalus epidemiology and outcomes in Lusaka, Zambia.</AbstractText>This retrospective cohort study included p... |
2,327,272 | The Variable Appearance of Third Ventricular Colloid Cysts: Correlation with Histopathology and the Risk of Obstructive Ventriculomegaly. | While third ventricular colloid cysts may present as an incidental finding, they also harbor the potential to cause ventricular obstruction and sudden death. Herein we analyze the relationship between imaging appearance and the risk of obstructive ventriculomegaly.</AbstractText>This is a retrospective review of the MR... |
2,327,273 | Spontaneous Intraparenchymal Tension Pneumocephalus. | Tension pneumocephalus is a treatable emergency that is usually caused by trauma or surgery. We present a rare case of spontaneous tension pneumocephalus. A 64-year-old woman presented with a severe aggravating headache. Computed tomography revealed a large air collection in the brain parenchyma of the right frontal lo... |
2,327,274 | Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression. | Sepsis-induced myocardial depression has high mortality and is very common in intensive care units. Previous studies have found that microRNAs play an important role in regulating sepsis-induced myocardial depression. miR-150-5p is involved in many biological processes; however, the mechanism underlying its role in sep... |
2,327,275 | Cardiac Lipoma of the Interventricular Septum. | Cardiac lipomas are rare benign primary neoplasms of the heart, usually found incidentally, that can become symptomatic depending on their size and location. We report the case of a 61-year-old man presenting with chest pain and elevated troponin and a normal EKG and D-dimers. A transthoracic echocardiogram revealed an... |
2,327,276 | Integrative Analysis Revealing Human Heart-Specific Genes and Consolidating Heart-Related Phenotypes. | Elucidating expression patterns of heart-specific genes is crucial for understanding developmental, physiological, and pathological processes of the heart. The aim of the present study is to identify functionally and pathologically important heart-specific genes by performing the Ingenuity Pathway Analysis (IPA). Throu... |
2,327,277 | A Special Cranial Nucleus (CSF-Contacting Nucleus) in Primates. | There is a unique nucleus (CSF-contacting nucleus) in the brain of rat. It has been demonstrated in our previous research. The extraordinary feature of this nucleus is that it is not connected to any parenchymal organ but to the CSF. In primates, however, the presence or absence of this nucleus has not been proven. Con... |
2,327,278 | Camel regulates development of the brain ventricular system. | Development of the brain ventricular system of vertebrates and the molecular mechanisms involved are not fully understood. The developmental genes expressed in the elements of the brain ventricular system such as the ependyma and circumventricular organs act as molecular determinants of cell adhesion critical for the f... |
2,327,279 | Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls. | People living with HIV (PLWH) have increased risk of cardiovascular diseases compared with uninfected populations. We assessed structural cardiac abnormalities and their associated risk factors in well-treated PLWH and uninfected controls using multidetector computed tomography (MDCT).</AbstractText>People living with ... |
2,327,280 | 'Possible shunt malfunction' pathway for paediatric hydrocephalus-a study of clinical outcomes and cost implications. | Shunt insertion for hydrocephalus is a common paediatric neurosurgery procedure. Shunt complications are frequent with an estimated 20-40% failure rate within the first year, and 4.5% per year subsequently. We have an open-door 'possible shunt malfunction' pathway for children treated with a shunt or endoscopic third v... |
2,327,281 | Longitudinal Volumetric Assessment of Ventricular Enlargement in Pet Dogs Trained for Functional Magnetic Resonance Imaging (fMRI) Studies. | Recent studies suggest that clinically sound ventriculomegaly in dogs could be a preliminary form of the clinically significant hydrocephalus. We evaluated changes of ventricular volumes in awake functional magnetic resonance imaging (fMRI) trained dogs with indirectly assessed cognitive abilities over time (thus avoid... |
2,327,282 | Topographical anatomy of the tentorium cerebelli and venous confluences in human midterm fetuses. | Early development of veins and sinuses at and around the posterior cranial fossa seemed not to be shown by photographs except for our recent study (Ann Anat, 2020). Examination of histological sections of 38 fetuses at 10-16 weeks gestational age (GA) demonstrated that: (1) the superior petrosal sinus passed posterosup... |
2,327,283 | Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival. | Choroid plexus tumors (CPTs) represent one of the most common intraventricular tumors. Although most are benign, they often reach considerable sizes before clinical manifestation, challenging their surgical management. We aim to describe the clinical characteristics and the impact of current management on the survival ... |
2,327,284 | The Role of the Brain in the Regulation of Peripheral Organs-Noradrenaline Sources in Neonatal Rats: Noradrenaline Synthesis Enzyme Activity. | This work is aimed at studying the mechanisms of reciprocal humoral regulation of noradrenaline-producing organs in rats in the perinatal period of development. The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h aft... |
2,327,285 | Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor. | Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease characterized by an antibody-mediated autoimmune response against NMDAR. Recent studies have shown that anti-NMDAR antibodies are involved in the pathophysiology of the disease. However, the upstream immune and inflammatory processes ... |
2,327,286 | [Two elderly cases of transthyretin amyloid polyneuropathy without a family history]. | We report two cases of transthyretin familial amyloid polyneuropathy (ATTR-FAP) from non-endemic areas. Both cases showed chronic progressive distal limb numbness and weakness. Due to nonspecific symptoms, they were not diagnosed for a long period of time. A nerve conduction study revealed axonal neuropathy in the lowe... |
2,327,287 | Endoscopic supracerebellar infratentorial approach to pineal and posterior third ventricle lesions in prone position with head extension: a technical note. | The supracerebellar infratentorial (SCIT) approach is frequently used for the treatment of lesions in the pineal and posterior third ventricle region and can be performed in a sitting or prone position. We describe our experience with the purely endoscopic SCIT approach, using a prone position, with neck extension and ... |
2,327,288 | Novel Endoscopic Technique for Inserting a Sheath into a Slit Ventricle: The Water-Slide Technique. | The efficacy and safety of endoscopic procedures for slit ventricle syndrome (SVS) have been presented in recent studies. However, inserting a sheath into a target ventricle is essential in the beginning of endoscopic procedures for SVS, and this maneuver is challenging owing to the quite narrow ventricular space. We r... |
2,327,289 | White Matter Hyperintensities Contribute to Language Deficits in Primary Progressive Aphasia. | To determine the contribution of white matter hyperintensities (WMH) to language deficits while accounting for cortical atrophy in individuals with primary progressive aphasia (PPA).</AbstractText>Forty-three individuals with PPA completed neuropsychological assessments of nonverbal semantics, naming, and sentence repe... |
2,327,290 | Genetics of Colloid Cyst in Monozygotic Twins: Case Report and Review of Literature. | Colloid cysts are rare developmental lesions, accounting for approximately 1% of intracranial tumors. Often, these benign lesions are asymptomatic, but they are associated with significant mortality as a result of acute hydrocephalus. This mortality in patients with vague or no symptoms dictates a need for better under... |
2,327,291 | Outcome improvement in cerebral ventriculitis after ventricular irrigation: a prospective controlled study. | Cerebral ventriculitis remains one of the most challenging neurosurgical conditions, with poor outcome and a long course of treatment and duration of hospital stay. Despite the current conventional management plans, i.e., using antibiotics in addition to CSF drainage, the outcome remains unsatisfactory in some cases, w... |
2,327,292 | New Benzofuran <i>N</i>-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis. | Diabetic obese patients are susceptible to the development of cardiovascular disease, including hypertension and cardiac dysfunction culminating in diabetic cardiomyopathy (DC), which represents a life-threatening health problem with increased rates of morbidity and mortality. The aim of the study is to characterize th... |
2,327,293 | Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA. | Cerebral malaria is one of the most severe pathologies of malaria; it induces neuro-cognitive sequelae and has a high mortality rate. Although many factors involved in the development of cerebral malaria have been discovered, its pathogenic mechanisms are still not completely understood. Most studies on cerebral malari... |
2,327,294 | IgM+ and IgT+ B Cell Traffic to the Heart during SAV Infection in Atlantic Salmon. | B cells of teleost fish differentiate in the head kidney, and spleen, and either remain in the lymphatic organs or move to the blood and peripheral tissues. There is limited knowledge about piscine B cell traffic to sites of vaccination and infection and their functional roles at these sites. In this work, we examined ... |
2,327,295 | Slit-like hypertensive hydrocephalus: Report of a late, complex, and multifactorial complication in an oncologic patient. | Several sophisticated techniques and many chemotherapy drugs have improved life expectancy of oncologic patients allowing us to observe late complications which present many years after the initial treatment.</AbstractText>We present a unique case of a patient affected by acute lymphoblastic leukemia at the age of 6 ye... |
2,327,296 | Polar Infection of Echovirus-30 Causes Differential Barrier Affection and Gene Regulation at the Blood-Cerebrospinal Fluid Barrier. | Echovirus-30 (E-30) is responsible for the extensive global outbreaks of meningitis in children. To gain access to the central nervous system, E-30 first has to cross the epithelial blood-cerebrospinal fluid barrier. Several meningitis causing bacteria preferentially infect human choroid plexus papilloma (HIBCPP) cells... |
2,327,297 | Depth relationships and measures of tissue thickness in dorsal midbrain. | Dorsal human midbrain contains two nuclei with clear laminar organization, the superior and inferior colliculi. These nuclei extend in depth between the superficial dorsal surface of midbrain and a deep midbrain nucleus, the periaqueductal gray matter (PAG). The PAG, in turn, surrounds the cerebral aqueduct (CA). This ... |
2,327,298 | ABHD4-dependent developmental anoikis safeguards the embryonic brain. | A specialized neurogenic niche along the ventricles accumulates millions of progenitor cells in the developing brain. After mitosis, fate-committed daughter cells delaminate from this germinative zone. Considering the high number of cell divisions and delaminations taking place during embryonic development, brain malfo... |
2,327,299 | Unusual Hydatid Cysts: Cardiac and Pelvic-Ilio femoral Hydatid Cyst Case Reports and Literature Review.<Pagination><StartPage>565</StartPage><EndPage>572</EndPage><MedlinePgn>565-572</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.21470/1678-9741-2019-0153</ELocationID><Abstract><AbstractText Label="... | Hydatid cyst is a parasitic disease caused by Echinococcus granulosus, most commonly seen in the liver and lungs. The hydatid cyst is rarely seen in the heart and iliofemoral region, representing less than 2% of all cases. In this article, we report our cases of hydatid cysts in unusual loci.</AbstractText>Between 2015... |
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