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2,327,000 | Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis. | The finding of fetal ventriculomegaly is variably associated with other fetal abnormalities and, even when isolated, is thought to be linked to abnormal neurodevelopmental outcome. The aim of this study was to undertake a systematic review and meta-analysis of the current literature to assess the prevalence of neurodev... |
2,327,001 | Outcomes of patients with prenatally diagnosed agenesis of the corpus callosum in conjunction with ventriculomegaly. | We evaluated the postnatal outcomes of patients with prenatally diagnosed agenesis of the corpus callosum (ACC), in conjunction with ventriculomegaly, as a tool for parental counseling.</AbstractText>Through a retrospective review of maternal and infant records, we evaluated the postnatal outcomes of 21 patients with p... |
2,327,002 | Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles. | While there is growing experimental evidence that cerebrospinal fluid (CSF) flow induced by the beating of ependymal cilia is an important factor for neuronal guidance, the respective contribution of vascular pulsation-driven macroscale oscillatory CSF flow remains unclear. This work uses computational fluid dynamics t... |
2,327,003 | Evaluation of hippocampus dose for patients undergoing intensity-modulated radiotherapy for nasopharyngeal carcinoma. | To evaluate the dose received by the hippocampus among patients undergoing intensity-modulated radiotherapy (IMRT) for nasopharyngeal cancer.</AbstractText>10 patients with biopsy-proven, locally advanced nasopharyngeal cancer constituted the study population. The total prescribed dose to the planning target volume (PT... |
2,327,004 | Contralateral interhemispheric approach to deep-seated cavernous malformations: surgical considerations and clinical outcomes in 31 consecutive cases. | Deep-seated periventricular cavernous malformations of the basal ganglia or thalamus can be approached via an interhemispheric craniotomy.</AbstractText>To determine surgical efficacy and clinical outcomes of the contralateral interhemispheric approach.</AbstractText>Retrospective chart review was performed on patients... |
2,327,005 | Effects of cross-sex hormone treatment on cortical thickness in transsexual individuals. | Untreated transsexuals have a brain cortical phenotype. Cross-sex hormone treatments are used to masculinize or feminize the bodies of female-to-male (FtMs) or male-to-female (MtFs) transsexuals, respectively.</AbstractText>A longitudinal design was conducted to investigate the effects of treatments on brain cortical t... |
2,327,006 | Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female rats. | This study investigated potential mechanisms by which age and IGF-I receptor (IGF-Ir) signaling in the neuroendocrine hypothalamus affect estradiol-positive feedback effects on GnRH neuronal activation and on kisspeptin and N-methyl-D-aspartate (NMDA)-induced LH release and on the abundance of NMDA receptor subunits Nr... |
2,327,007 | Sylvius aqueduct septum. | We present a case of chronic hydrocephalus discovered in adulthood through an episode of acute decompensation. Multimodal imaging revealed the cause of this hydrocephalus to be a membranous septum of the aqueduct of Sylvius, a condition for which few reports exist. |
2,327,008 | MR and applanation tonometry derived aortic impedance: association with aging and left ventricular remodeling. | We sought to noninvasively estimate aortic impedance indices from MR and tonometric data.</AbstractText>MR aortic velocity-encoded and carotid applanation tonometry pressure data of 70 healthy subjects (19-79 years) were used to calculate the following indices from impedance spectrum: (i) characteristic impedance (Zc) ... |
2,327,009 | Visual Evoked Potentials in Infants With Diffuse Periventricular Leukomalacia. | Periventricular leukomalacia (PVL) is characterized by necrosis of the cerebral white matter in the dorsolateral portions of the lateral ventricles. PVL causes motor, sensory, and cognitive deficits. The aim of this study was to analyze the conduction characteristics of the visual pathway in infants with diffuse PVL us... |
2,327,010 | The pathologic spectrum of oculoleptomeningeal amyloidosis with Val30Gly transthyretin gene mutation in a postmortem case. | We report the clinical and postmortem pathologic features of a 60-year-old woman with oculoleptomeningeal amyloidosis with a Val30Gly transthyretin gene mutation. Unlike other forms of hereditary amyloidosis, this rare type displays amyloid deposition predominantly in the eyes and central nervous system. Our patient be... |
2,327,011 | Perinatal characteristics of fetuses with borderline ventriculomegaly detected by routine ultrasonographic screening of low-risk populations. | Fetal borderline ventriculomegaly represents a frequent dilemma in perinatal management. The present study aimed to evaluate the clinical significance of fetal borderline ventriculomegaly in a low-risk Japanese population and to identify the risk factors for associated anomalies.</AbstractText>Data of cases of fetal bo... |
2,327,012 | Outcome of congenital diaphragmatic hernia with indication for Fontan procedure. | The aim of this study was to clarify the outcome of patients with cardiovascular malformation (CVM) among those with congenital diaphragmatic hernia (CDH) who are indicated for the Fontan procedure.</AbstractText>The subjects included 76 CDH patients with CVM recruited from a national survey of 614 CDH patients. The ou... |
2,327,013 | Pregnancy and vaginal delivery in epidural analgesia in woman with cerebrospinal fluid shunt. | Hydrocephalus is a medical condition characterized by enlargement of cerebral ventricles due to abnormal cerebrospinal fluid accumulation. Hydrocephalic women with cerebrospinal fluid (CSF) shunts are now surviving to reproductive age, but still there are doubts regarding the mode of delivery, analgesia and anesthesia.... |
2,327,014 | Transforming Growth Factor-α Improves Memory Impairment and Neurogenesis Following Ischemia Reperfusion. | Stroke is most important cause of death and disability in adults. The hippocampal CA1 and sub-ventricular zone neurons are vulnerable to ischemia that can impair memory and learning functions. Although neurogenesis normally occurs in the dentate gyrus (DG) of the hippocampus and sub-ventricular zone (SVZ) following bra... |
2,327,015 | A microstructural model of reentry arising from focal breakthrough at sites of source-load mismatch in a central region of slow conduction. | Regions of cardiac tissue that have a combination of focal activity and poor, heterogeneous gap junction coupling are often considered to be arrhythmogenic; however, the relationship between the properties of the cardiac microstructure and patterns of abnormal propagation is not well understood. The objective of this s... |
2,327,016 | Correlation of prenatal and postnatal MRI findings in schizencephaly. | Schizencephaly is a rare malformation of the brain characterized by a gray matter-lined defect extending from the pial surface to the lateral ventricles. The purpose of this study was to correlate imaging findings of schizencephaly and associated anomalies on fetal and postnatal MR imaging and assess possible changes t... |
2,327,017 | [Reversible porencephalic cyst related to shunt dysfunction]. | The surgical treatment of hydrocephalus is one of the most commonly procedures of modern pediatric neurosurgical practice, and cerebrospinal fluid shunts are the main means of treatment of hydrocephalus, being independent of site of obstruction and ventricular shunt complications are frequent, especially in children. T... |
2,327,018 | Transvenous Onyx embolization of a subependymal deep arteriovenous malformation with a single drainage vein: technical note. | Cerebral arteriovenous malformations (AVMs) are uncommon. Treatment options include embolization, radiosurgery and surgery, separately or combined, the final goal being complete occlusion of the malformation. We describe the case of a symptomatic small subependymal AVM with a single deep drainage vein previously treate... |
2,327,019 | [Lipomatous ependymomas of the posterior fossa. An infrequent and little-known subtype. A case report and review of the literature]. | Ependymomas are well defined glial tumours composed of uniform small cells with round nuclei in a fibrillar matrix. They have characteristic perivascular acellular areas (pseudorosettes) and, in some cases, ependymal rosettes. The three most well-known histological phenotypes are papillary, clear-cell and tanycytic. Th... |
2,327,020 | Influences of Serotonin Hydrochloride on <i>Adiponectin</i>, <i>Ghrelin</i> and <i>KiSS1</i> Genes Expression. | Serotonin and kisspeptin stimulates gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) release while ghrelin and adiponectin inhibit them. In the present experimental study, the effects of central injection of serotonin were investigated on LH concentration, KiSS1</i>, adiponectin</i>, and ghrelin</i> g... |
2,327,021 | Intraventricular Free-Floating Thrombus in an Impella-Supported Patient: Damage Control in a No-Win Scenario. | We describe the management and clinical decision making in a cardiogenic shock patient with a free-floating left ventricular thrombus found during temporary mechanical support with an Impella CP. The management of these patients can be challenging because there are no guidelines or data to support any particu... |
2,327,022 | Successful Retrieval of a 4-Year-Old Micra Transcatheter Pacemaker System in a Patient With Leadless Biventricular Pacing Therapy. | This is the first report of the management of a patient with cardiac resynchronization therapy using leadless biventricular pacing. Successful retrieval of a 4-year-old Micra transcatheter pacing system (TPS) and reimplantation of a new Micra TPS prevented device-to-device interactions from multiple paci... |
2,327,023 | Endocardial fibroelastosis and dilated cardiomyopathy - the past and future of the interface between histology and genetics.<Pagination><StartPage>999</StartPage><EndPage>1005</EndPage><MedlinePgn>999-1005</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.47162/RJME.61.4.02</ELocationID><Abstract><Abst... | Endocardial fibroelastosis (EFE) signifies the pathological process by which collagen and elastin are focally or diffuse deposited in the endocardium of the left ventricle. The new layer causes left ventricular dysfunction sometimes with fulminant progression to heart failure. EFE is a major component in many congenita... |
2,327,024 | Preterm Birth With Neonatal Interventions Accelerates Collagen Deposition in the Left Ventricle of Lambs Without Affecting Cardiomyocyte Development. | Adults born preterm (< 37 weeks' gestation) exhibit altered cardiac growth and are susceptible to cardiac dysfunction. Sheep studies have shown that moderate preterm birth results in maladaptive structural remodelling of the cardiac ventricles. The aim of this study was to examine ventricular structure in lambs born... |
2,327,025 | Intracerebroventricular delivery of vascular endothelial growth factor in patients with amyotrophic lateral sclerosis, a phase I study. | We studied the feasibility, safety, tolerability and pharmacokinetics of intracerebroventricular delivery of recombinant human vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. In this phase I study in patients with amyotrophic lateral sclerosis, the study drug was delivered using an im... |
2,327,026 | A transgenic pig model expressing a CMV-ZsGreen1 reporter across an extensive array of tissues. | Since genetic engineering of pigs can benefit both biomedicine and agriculture, selecting a suitable gene promoter is critically important. The cytomegalovirus (CMV) promoter, which can robustly drive ubiquitous transgene expression, is commonly used at present, yet recent reports suggest tissue-specific activity in th... |
2,327,027 | Mechanical stimuli for left ventricular growth during pressure overload. | The mechanical stimulus (i.e. stress or stretch) for growth occurring in the pressure-overloaded left ventricle (LV) is not exactly known.</AbstractText>To address this issue, we investigate the correlation between local ventricular growth (indexed by local wall thickness) and the local acute changes in mechanical stim... |
2,327,028 | Endoscopic Third Ventriculostomy and Simultaneous Tumor Biopsy in Pineal Region Tumors using the "Single Burr Hole" Technique: An Analysis of 34 Cases. | Pineal region tumors often present with hydrocephalus. Endoscopic third ventriculostomy (ETV) and simultaneous tumor biopsy remain a minimally invasive procedure offering both diagnostic and therapeutic advantages in the management of these tumors. However, different operative techniques have been described in the lite... |
2,327,029 | Ontogeny of adult neural stem cells in the mammalian brain. | Neural stem cells (NSCs) persist into adulthood in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and in the ventricular-subventricular zone (V-SVZ) of the lateral ventricles, where they generate new neurons and glia cells that contribute to neural plasticity. A better understanding of the developme... |
2,327,030 | Alcohol and Cocaine Combined Substance Use on Adult Hypothalamic Neural Stem Cells and Neurogenesis. | Many advancements have been made over the years looking at the individual and combined effects of drugs of abuse on the brain, with one key area of research focusing on the effects on neurogenesis. An integral part of fetal brain development and, later, maintenance in the adult brain, neurogenesis occurs in three main ... |
2,327,031 | Effects of Pretreatment With Ginseng Extract on Dopamine D2 Receptor Analgesia. | The ginseng extract is an herb that has been used for many purposes such as analgesic effect. Dopamine D2 receptors are involved in the regulation of pain in humans. Therefore, the present investigation aims to study how pretreatment with aqueous-alcoholic extract of ginseng can affect dopamine D2 receptors' pain sensi... |
2,327,032 | Colloid Cyst of the Third Ventricle: Case report and Literature Review. | Colloid cysts account for approximately 1% of all intracranial tumors and are the most common type of the neuroepithelial cysts. They are benign, that most commonly occur in the third ventricle near the Monro foramen. Sometimes they have no specific sings and symptoms and may be confused and misdiagnosed with other pat... |
2,327,033 | S100A8 Promotes Inflammation <i>via</i> Toll-Like Receptor 4 After Experimental Traumatic Brain Injury.<Pagination><StartPage>616559</StartPage><MedlinePgn>616559</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">616559</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3389/fnins.2020.616559</ELocati... | Cardiac tamponade is a pericardial syndrome characterised by an impairment of the diastolic filling of the ventricles causing reduction of cardiac output, usually producing signs and symptoms of cardiac arrest, if untreated. The main causes of cardiac tamponade include percutaneous cardiac interventions, malignacies, i... |
2,327,034 | Proton versus Photon Breath-Hold Radiation for Left-Sided Breast Cancer after Breast-Conserving Surgery: A Dosimetric Comparison. | Radiation to breast, chest wall, and/or regional nodes is an integral component of breast cancer management in many situations. Irradiating left-sided breast and/or regional nodes may be technically challenging because of cardiac tolerance and subsequent risk of long-term cardiac complications. Deep inspiratory breath-... |
2,327,035 | Venous bullet embolism to the right ventricle: Case report and review of management. | Intravascular missile emboli to the right heart should be retrieved surgically if the risk of surgical complication due to sternotomy and cardiotomy is low. Endovascular retrieval is another possible method of extraction to be considered. |
2,327,036 | Left ventricular hypoplasia: to septate or not? | When do we label a left ventricle as small? How is the decision made regarding suitability for a two-ventricle repair? Are dimensions the only criteria with which we decide, whether a ventricle will support the systemic circulation? Can we actually stimulate the growth of a borderline small left ventricle, so that it c... |
2,327,037 | Where are we after 50 years of the Fontan operation? | First introduced in 1971, the Fontan procedure is the final common destination for all patients with a functional single ventricle. The procedure itself has evolved tremendously over the last five decades. This review traces this journey and presents the importance, outcomes and future outlook of the procedure in the c... |
2,327,038 | Navigated Endoport in the Purely Endoscopic Microsurgery of Intraventricular and Other Deep-Seated Brain Lesions: A Case Report. | Brain parenchyma retraction is often necessary to reach various deep brain lesions during surgery. In order to minimise the incidence of the brain retraction injury, an endoport system may be employed. We present a report of a navigated endoport system in conjunction with an purely endoscopic microsurgery that was used... |
2,327,039 | Right and Left Ventricular Takotsubo: Same Two-Headed Monster or Different Beasts? | Right ventricular involvement in takotsubo cardiomyopathy is poorly understood and may be more common than previously reported. The significant hemodynamic ramification of this condition is elicited in this case report in which an 81-year-old female suffered a deadly biventricular takotsubo cardiomyopathy with subseque... |
2,327,040 | Colloid cyst curtailed: A case report of spontaneous colloid cyst regression. | Colloid cysts arise from the roof of the third ventricle and are at risk for obstructing the flow of cerebrospinal fluid (CSF) and causing increased intracranial pressure. With advancements and increased frequency of imaging, colloid cysts are sometimes discovered incidentally. In these cases, the neurosurgeon is faced... |
2,327,041 | Effect of hyperbaric oxygen therapy on the healing of postoperative wounds in bitches after hemimastectomy. | The use of hyperbaric oxygen therapy (HBOT) is an accepted method of supporting wound healing in human medicine. Yet, because of the risk of complications associated with HOBT, a safer modification of the therapy, known as L-HOBT (lower pressure and lower oxygen concentration), is increasingly used nowadays. Therefore,... |
2,327,042 | Cognitive enhancement and neuroprotective effects of a traditional Chinese herbal compound medicine on Aβ1-42 induced Alzheimer's disease in rats. | We aimed to explore the role of a novel traditional herbal compound medicine (HCM) in Alzheimer's disease (AD).</AbstractText>72 rats were randomized into control, AD, Donepezil and HCM groups. Injection of -amyloid peptide (A1-42) into the lateral ventricle was used to induce AD in rats. Rats in t... |
2,327,043 | Patient and Family Experience in a Multidisciplinary Clinic for Children With Single-Ventricle Heart Disease. | Children with single-ventricle heart disease (SVHD) are at risk for morbidity across multiple organ systems. A single-ventricle multidisciplinary clinic (SVMDC) may address complex health-care needs by providing access to, and coordination among, pediatric subspecialties. However, the patient and family experience of m... |
2,327,044 | Intracranial migration of intraocular silicone oil mimicking metastatic disease. | Silicone oil (SO) is a commonly used agent of intraocular endotamponade for treating complicated retinal detachment. We report a case of SO migration into the cerebral ventricles which was initially misdiagnosed as metastatic disease. Misinterpretation of SO as metastatic disease in a patient with a lung nodule trigger... |
2,327,045 | IDH1-mutant primary intraventricular gliosarcoma: Case report and systematic review of a rare location and molecular profile. | Gliosarcoma (GS) is classified as an IDH-wild-type variant of glioblastoma (GBM). While GS is already an unusual presentation of GBM, IDH1-mutant cases are especially rare. We present an IDH1-mutant primary intraventricular GS case report and a systematic review of the molecular profile in GS correlating to the prognos... |
2,327,046 | Importance of Hydrostatic Pressure and Irrigation for Hemostasis in Neuroendoscopic Surgery. | Recently neurosurgical operations have been carried out with water irrigation such as endoscopic third ventriculostomy and tumor resections in ventricles. Water irrigation is one of several published methods that promote hemostasis; however, not enough experimental evidence exists on its efficacy. In this study, we inv... |
2,327,047 | Coexisting Retrocerebellar Arachnoid Cyst and Chiari Type 1 Malformation: 3 Pediatric Cases of Surgical Management Tailored to the Pathogenic Mechanism and Systematic Review of the Literature. | Arachnoid cysts are benign cerebrospinal fluid collection within a duplication of arachnoid membrane and, when found in the retrocerebellar site, they may be associated with tonsils herniation. This rare situation of coexisting retrocerebellar arachnoid cyst (AC) and Chiari malformation type 1 (CM-1) have been previous... |
2,327,048 | The Neuroanatomic Studies of Albert L. Rhoton Jr. in Historical Context: An Analysis of Origin, Evolution, and Application. | The incorporation of perspective into art and science revolutionized the study of the brain. Beginning in about 1504, Leonardo da Vinci began to model the ventricles of the brain in three dimensions. A few years later, Andreus Vesalius illustrated radically novel brain dissections. Thomas Willis' work, Cerebri Anatome ... |
2,327,049 | Isolation of Neuroprotective Anthocyanins from Black Chokeberry (<i>Aronia melanocarpa</i>) against Amyloid-β-Induced Cognitive Impairment. | Black chokeberry (<i>Aronia melanocarpa</i>) fruits are rich in anthocyanins, which are vital secondary metabolites that possess antioxidative properties. The aim of this study was to isolate and purify the anthocyanins from black chokeberry by simulated moving bed (SMB) chromatography, and to investigate the neuroprot... |
2,327,050 | DEEP MOUSE: AN END-TO-END AUTO-CONTEXT REFINEMENT FRAMEWORK FOR BRAIN VENTRICLE & BODY SEGMENTATION IN EMBRYONIC MICE ULTRASOUND VOLUMES. | The segmentation of the brain ventricle (BV) and body in embryonic mice high-frequency ultrasound (HFU) volumes can provide useful information for biological researchers. However, manual segmentation of the BV and body requires substantial time and expertise. This work proposes a novel deep learning based end-to-end au... |
2,327,051 | The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model. | Histamine is a basic amine stored in mast cells, with its release capable of activating one of four histamine receptors. The histamine 3 receptor (H<sub>3</sub>R) is known to be cardioprotective during acute ischemia by acting to limit norepinephrine release. However, a recent study reported that myofibroblasts isolate... |
2,327,052 | To Shunt or Not to Shunt Patients with Idiopathic Normal Pressure Hydrocephalus? A Reappraisal of an Old Question. | The possibility that the cerebral ventricles can dilate without any increase in the pressure of the cerebrospinal fluid (CSF) was recognized in 1935 by Penfield who reported a patient in whom "…the cerebrospinal fluid spaces are closed and the ventricles progressively enlarge without the measured intraventricula... |
2,327,053 | Challenges in Modeling Human Neural Circuit Formation via Brain Organoid Technology. | Human brain organoids are three-dimensional self-organizing tissues induced from pluripotent cells that recapitulate some aspects of early development and some of the early structure of the human brain <i>in vitro</i>. Brain organoids consist of neural lineage cells, such as neural stem/precursor cells, neurons, astroc... |
2,327,054 | Clinico-radiological characteristics, histo-pathological features and long-term survival outcomes in central neurocytoma: A single-institutional audit. | Central neurocytoma is a rare benign brain tumor that typically arises from the subependymal lining of the lateral ventricles in young adults and is generally associated with excellent survival following neurosurgical excision alone. This is a retrospective clinical audit of biopsy-proven neurocytoma registered between... |
2,327,055 | Thermoresponsive polysaccharides with tunable thermoresponsive properties via functionalisation with alkylamide groups. | Polysaccharides have been used widely in many industries, from food technology and mining to cosmetics and biomedical applications. Over recent years there has been growing interest in the development of responsive polysaccharides with unique and switchable properties, particularly systems that display lower-critical s... |
2,327,056 | Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination. | Demyelinated lesions in human pons observed after osmotic shifts in serum have been referred to as central pontine myelinolysis (CPM). Astrocytic damage, which is prominent in neuroinflammatory diseases like neuromyelitis optica (NMO) and multiple sclerosis (MS), is considered the primary event during formation of CPM ... |
2,327,057 | c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer's Diseases. | Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the world. Regarding the cognitive decline caused by the disease, mitogen-activated protein kinases (MAPK) pathways such as the c-Jun N-terminal ki... |
2,327,058 | A case undergoing cocktail therapy for cardiac involvement in Barth syndrome.<Pagination><StartPage>1393</StartPage><EndPage>1395</EndPage><MedlinePgn>1393-1395</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ped.14342</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abe</La... | Double-chambered left ventricle (DCLV) is a rare congenital abnormality and is characterized by the subdivision of the left ventricle into two separate chambers by an abnormal septum or muscle band. This rare congenital entity is usually diagnosed in the neonatal or pediatric age. Nevertheless, it can be asymptomatic a... |
2,327,059 | Environment permissible concentrations of glyphosate in drinking water can influence the fate of neural stem cells from the subventricular zone of the postnatal mouse. | The developing nervous system is highly vulnerable to environmental toxicants especially pesticides. Glyphosate pesticide induces neurotoxicity both in humans and rodents, but so far only when exposed to higher concentrations. A few studies, however, have also reported the risk of general toxicity of glyphosate at conc... |
2,327,060 | Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia. | The main stem cell niche for neurogenesis in the adult mammalian brain is the subventricular zone (SVZ) that extends along the cerebral lateral ventricles. We aimed at characterizing the initial molecular responses of the macaque monkey SVZ to transient, global cerebral ischemia. We microdissected tissue lining the ant... |
2,327,061 | A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups. | Germinal matrix hemorrhage (GMH) is a serious complication in extremely preterm infants associated with neurological deficits and mortality. The purpose of the present study was to develop and characterize a grade III and IV GMH model in postnatal day 5 (P5) rats, the equivalent of preterm human brain maturation. P5 Wi... |
2,327,062 | Trans-lamina terminalis suprategmental approach for ventral midbrain lesions: Technical note. | Surgical resection of lesions located in the ventral midbrain is challenging. Few approaches and safe entry zones (SEZs) have been proposed and used to remove this type of lesion, and each has its limitations. Using two illustrating cases, the authors describe a trans-lamina terminalis suprategmental approach for remov... |
2,327,063 | Surgical management of the fourth ventricular tumors using telovelar approach and the role of neuroendoscopy: Post-operative outcome and long-term results in a series of 52 cases. | The telovelar approach is a surgical method performed through natural corridors of the brain to access the fourth ventricle. The aim of this study is to assess the results of this approach as well as the role of neuroendoscopy in surgical management of fourth ventricle tumors.</AbstractText>A retrospective study was de... |
2,327,064 | Temporal trends in surgical procedures for pediatric hydrocephalus: an analysis of the Hydrocephalus Clinical Research Network Core Data Project. | Analysis of temporal trends in patient populations and procedure types may provide important information regarding the evolution of hydrocephalus treatment. The purpose of this study was to use the Hydrocephalus Clinical Research Network's Core Data Project to identify meaningful trends in patient characteristics and t... |
2,327,065 | Modified hemispherectomy for infantile hemiparesis and epilepsy. | To investigate the effect and medical imaging of modified hemispherectomy on patients with infantile hemiparesis and medically refractory epilepsy.</AbstractText>Forty-three patients with infantile hemiparesis and refractory epilepsy who underwent hemispherectomy were enrolled. The treatment effect and medical imaging ... |
2,327,066 | Decreased MiR-30a promotes TGF-β1-mediated arachnoid fibrosis in post-hemorrhagic hydrocephalus. | Fibrosis in the ventricular system is closely associated with post-hemorrhagic hydrocephalus (PHH). It is characterized by an expansion of the cerebral ventricles due to CSF accumulation following intraventricular hemorrhage (IVH). The activation of transforming growth factor-β1 (TGF-β1) may be involved in ... |
2,327,067 | Tympanic Membrane Rupture During Stereotaxic Surgery Disturbs the Normal Feeding Behavior in Rats. | Stereotactic surgery is a widely used procedure in neuroscience research to study the brain's regulation of feeding behavior. In line with this notion, this study aims to assess how food consumption and feeding patterns are affected in response to the use of auditory bars that preserve or damage the tympanic membrane d... |
2,327,068 | To Become or Not to Become Tumorigenic: Subventricular Zone <i>Versus</i> Hippocampal Neural Stem Cells. | Neural stem cells (NSCs) persist in the adult mammalian brain in two neurogenic regions: the subventricular zone lining the lateral ventricles and the dentate gyrus of the hippocampus. Compelling evidence suggests that NSCs of the subventricular zone could be the cell type of origin of glioblastoma, the most devastatin... |
2,327,069 | Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity <i>in vivo</i>. | Neuroinflammation is an important factor in the pathogenesis of neurodegenerative diseases. Microglia-derived lysosomal cathepsins have been increasingly recognized as important inflammatory mediators that trigger signaling pathways that aggravate neuroinflammation. <i>In vitro</i>, a contribution to neuroinflammation ... |
2,327,070 | History of the Concept of Tuberculous Meningitis. | More than a century separates the description of "dropsy of the ventricles of the brain" by Scottish physicians and Robert Koch's identification of the causal agent of tuberculous meningitis in 1882. This article reviews the writings in Scotland and France that marked the history of the identification of this infectiou... |
2,327,071 | CNS macrophages differentially rely on an intronic <i>Csf1r</i> enhancer for their development. | The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated macrophages (BAMs). Microglia, but not BAMs, were reported to be absent in mice lacking a conserved <i>Csf1r</i> enhancer: the <i>fms</i>-intronic regulatory element (FIRE... |
2,327,072 | TDMQ20, a Specific Copper Chelator, Reduces Memory Impairments in Alzheimer's Disease Mouse Models. | Besides targeting amyloid or tau metabolisms, regulation of redox metal ions is a recognized therapeutic target for Alzheimer's disease (AD). Based on the bioinorganic chemistry of copper, we designed specific chelators of copper(II) (TDMQs) insight to regulate copper homeostasis in the brain and to inhibit the deleter... |
2,327,073 | REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment. | Alzheimer's disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mechanisms involved in Aβ pathology, much remains unknown. Previous ... |
2,327,074 | A long-term follow-up of safety and clinical efficacy of NTCELL® [Immunoprotected (Alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease. | In 2019, we published the results of a Phase IIb randomized controlled trial of putaminal encapsulated porcine choroid plexus cell (termed NTCELL®) administration in patients with Parkinson's disease. This study failed to meet its primary efficacy end-point of a change in UPDRS part III score in the 'off' state at... |
2,327,075 | Clinical and radiological characteristics in fatal third ventricle colloid cyst. Literature review. | Colloid cysts are a benign tumor that is almost exclusively found in the third ventricle and may cause hydrocephalus and rarely life-threatening acute deterioration and even sudden death. With very few cases of sudden death reported in literature not much is known about the patient and cyst characteristics in these pat... |
2,327,076 | Solitary subependymal giant cell astrocytoma: Case report and review of the literature. | Tuberous sclerosis complex (TSC) is a multisystem autosomal dominant hamartoma syndrome caused by mutations in TSC1 or TSC2 genes, leading to upregulation of cell growth signalling pathways. Subependymal giant cell astrocytomas (SEGAs) are seen almost exclusively in TSC patients. We report a 'solitary SEGA' in an adult... |
2,327,077 | Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells. | The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy-the gain and/or loss of chromosomes-which is associated with mitotic spindle defects. The mitotic spindle orientation determines cleavage plane positi... |
2,327,078 | Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential. | Extracellular vesicles (EVs) have been implicated mechanistically in the pathobiology of neurodegenerative disorders, including central nervous system injury. However, the role of EVs in spinal cord injury (SCI) has received limited attention to date. Moreover, technical limitations related to EV isolation and characte... |
2,327,079 | Is local radiotherapy a viable option for patients with an opening of the ventricles during surgical resection of brain metastases? | Local hypofractionated stereotactic radiotherapy (HFSRT) of the resection cavity is emerging as the standard of care in the treatment of patients with a limited number of brain metastases as it warrants less neurological impairment compared to whole brain radiotherapy. In periventricular metastases surgical resection c... |
2,327,080 | Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease. | Alzheimer's disease (AD) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of hyperphosphorylated Tau protein. These changes lead to progressive neuronal degeneration and dysfunction, resulting in severe brain atrophy and ... |
2,327,081 | Percutaneous device closure of an aorto-right ventricular outflow tract fistula after Bentall repair.<Pagination><StartPage>1154</StartPage><EndPage>1155</EndPage><MedlinePgn>1154-1155</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00015385.2020.1824739</ELocationID><AuthorList CompleteYN="Y"><... | Adult posterior fossa ependymomas (PF-EPN) with preoperative cerebrospinal metastases are extremely rare. Only 3 cases have been reported in previous literature.</AbstractText>A case of a 32-year-old male patient complained of headaches for three months. Pure tone audiometry showed a slight decrease in bilateral hearin... |
2,327,082 | Intrathecal and intracerebroventricular dopamine for Parkinson's disease. | While CDD directly to the CSF can provide a constant delivery of the dopaminergic drug resulting in a more stable treatment effect without the limitations of traditional oral therapy without peripheral effects, it is still young and longitudinal data is lacking. These experimental therapies show promise and further inv... |
2,327,083 | Maternal Infection Impairs Fetal Brain Development via Choroid Plexus Inflammation. | In this issue of Developmental Cell, Cui et al. use a mouse model of maternal infection to identify that the embryonic choroid plexus propagates maternal inflammatory signals into the developing brain by enhancing macrophage infiltration across the choroid plexus barrier and releasing pro-inflammatory cytokines. |
2,327,084 | miR-34a attenuates myocardial fibrosis in diabetic cardiomyopathy mice via targeting Pin-1.<Pagination><StartPage>642</StartPage><EndPage>653</EndPage><MedlinePgn>642-653</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/cbin.11512</ELocationID><Abstract><AbstractText>Diabetic cardiomyopathy (DCM)... | Diabetic cardiomyopathy (DCM) is characterized by myocardial hypertrophy and fibrosis. This study aimed to investigate the effects of microRNA (miR)-34a on myocardial fibrosis in DCM and its potential mechanism of targeting Pin-1 signaling. Vimentin and Pin-1 proteins in mouse cardiac tissues were detected by immunohis... |
2,327,085 | Incisión de Spangaro en lesiones cardiacas penetrantes, reporte de casos. | <AbstractText Label="INTRODUCCIÓN" NlmCategory="UNASSIGNED">El trauma en México es un problema mayor de salud pública, siendo una de las principales causas de mortalidad en personas jóvenes. La incidencia reportada de trauma cardiaco varía. El sitio primario de lesión miocárdica es la... |
2,327,086 | Endoscopic antegrade aqueductoplasty and stenting with panventricular catheter in management of trapped fourth ventricle in patients with inadequately functioning supratentorial shunt. | Trapped fourth ventricle (TFV) usually develops as a complication of supratentorial ventricular CSF shunting, especially when hydrocephalus is caused by intraventricular hemorrhage and/or infection. This study aimed to assess the feasibility of endoscopic aqueduct stenting using a single refashioned shunt tube to treat... |
2,327,087 | Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia. | The aim of this study was to assess different amyloid beta subspecies' effects on behaviour and cognition in mice and their interaction with isoflurane anaesthesia.</AbstractText>After governmental approval, cannulas were implanted in the lateral cerebral ventricle. After 14 days the mice were randomly intracerebrovent... |
2,327,088 | Generation of brain organoids from mouse ESCs via teratoma formation. | Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs), can differentiate into all cell types in the body; therefore, they are used in the study of development and regenerative medicine. Neural lineage differentiation from PSCs is the initial step to study neurodevelopment and in vitro disease modeling. B... |
2,327,089 | A solitary extraventricular subependymal giant cell astrocytoma in the absence of tuberous sclerosis. | Subependymal giant cell astrocytomas (SEGAs) are the most common intracranial tumors in Tuberous Sclerosis Complex (TSC). Very few cases of solitary SEGA without a diagnosis of TSC have been described. Most of these previously reported solitary SEGAs were located near the caudothalamic groove or in close proximity to t... |
2,327,090 | A combination of lycopene and human amniotic epithelial cells can ameliorate cognitive deficits and suppress neuroinflammatory signaling by choroid plexus in Alzheimer's disease rat. | Neuroinflammation characterized by glial activation and release of proinflammatory mediators is considered to be correlated with cognitive deficits in Alzheimer's disease (AD). Previously, some studies have demonstrated that lycopene (LYCO) or human amniotic epithelial cells (HAECs) could attenuate inflammation in AD. ... |
2,327,091 | L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA<sub>1</sub>. | Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing hippocampal neurogenesis, but wheth... |
2,327,092 | Selective Neuroendoscopic Resection of the Choroid Plexus as an Alternative Technique for Optimizing the Standard Endoscopic Approach to Hydrocephalus. | In the past four decades, enormous advances have been made in the neuroendoscopic techniques, along with improvement of illumination, and the development of effective instruments. As a result, endoscopic third ventriculostomy (ETV) and choroid plexus cauterization (CPC) have become consolidated techniques for the treat... |
2,327,093 | Weak genetic signal for phenotypic integration implicates developmental processes as major regulators of trait covariation. | Phenotypic integration is an important metric that describes the degree of covariation among traits in a population, and is hypothesized to arise due to selection for shared functional processes. Our ability to identify the genetic and/or developmental underpinnings of integration is marred by temporally overlapping ce... |
2,327,094 | High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. | Adult neural stem cells (NSC) serve as a reservoir for brain plasticity and origin for certain gliomas. Lineage tracing and genomic approaches have portrayed complex underlying heterogeneity within the major anatomical location for NSC, the subventricular zone (SVZ). To gain a comprehensive profile of NSC heterogeneity... |
2,327,095 | Contralateral Interhemispheric Transfalcine Transprecuneus Approach: Advancing Operative Angles to Deep-Seated Lesions. | The reach to expose the peritrigonal/atrial territories poses special challenges. The highly functional overlying cortices and white matter tracts, such as the optic radiations lateral to the ventricle, postcentral gyrus laterally and more superficially, and the thalamus anteroinferiorly, constrain the surgical corrido... |
2,327,096 | Assessment of pulmonary arterial stiffness in patients with cirrhosis: A prospective cohort study.<Pagination><StartPage>57</StartPage><EndPage>63</EndPage><MedlinePgn>57-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/echo.14935</ELocationID><Abstract><AbstractText Label="INTRODUCTION">In th... | Mouse models play a crucial role in arrhythmia research and allow studying key mechanisms of arrhythmogenesis including altered ion channel function and calcium handling. For this purpose, atrial or ventricular cardiomyocytes of high quality are necessary to perform patch-clamp measurements or to explore calcium handli... |
2,327,097 | Metastatic melanoma of unknown origin mimicking neurofibromatosis. | We present an unusual case of metastatic melanoma in a young patient with imaging appearance resembling neurofibromatosis. A 36-year-old-man with a history of cervical radiculopathy presented with cauda equina syndrome. An MRI was performed for further evaluation demonstrating multiple intradural, extramedullary enhanc... |
2,327,098 | High-Pressure Normocephalus-Raised Intracranial Pressure with False Localizing Signs. | Normal-sized ventricles and absence of papilledema do not rule out shunt failure and raised intracranial pressure (ICP). Raised ICP can present with false localizing signs which may be cranial nerve palsies or extensive polyradiculopathy. Our patient with a history of ventriculoperitoneal (VP) shunt presented with rapi... |
2,327,099 | Comparison of the keyhole trans-middle temporal gyrus approach and transsylvian approach for selective amygdalohippocampectomy: A single-center experience. | Several approach routes exist for selective amygdalohippocampectomy (SAH); however, previous reports regarding a comparison of these routes are limited. Here, we compared trans-middle temporal gyrus (T2) SAH and transsylvian (TS) SAH in terms of seizure outcome, visual-field defect, memory function, and operation time ... |
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