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2,327,500 | Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing. | Approximately 30,000 patients with blunt cardiac trauma are recorded each year in the United States. Blunt cardiac injuries after trauma are associated with a longer hospital stay and a poor overall outcome. Organ damage after trauma is linked to increased systemic release of pro-inflammatory cytokines and damage-assoc... |
2,327,501 | P73 C-terminus is dispensable for multiciliogenesis. | The p53 family transcriptional factor p73 plays a pivotal role in development. Ablation of p73 results in severe neurodevelopmental defects, chronic infections, inflammation and infertility. In addition to this, Trp73<sup>-\-</sup> mice display severe alteration in the ciliated epithelial lining and the full-length <i>... |
2,327,502 | Mild Cognitive Impairment Staging Yields Genetic Susceptibility, Biomarker, and Neuroimaging Differences. | While Alzheimer's disease (AD) is divided into severity stages, mild cognitive impairment (MCI) remains a solitary construct despite clinical and prognostic heterogeneity. This study aimed to characterize differences in genetic, cerebrospinal fluid (CSF), neuroimaging, and neuropsychological markers across clinician-de... |
2,327,503 | Full-mouth Rehabilitation of a Ventriculoperitoneal Shunt-treated Hydrocephalic Pediatric Patient: A Case Report. | Hydrocephalus is characterized by accumulation of cerebrospinal fluid in the lateral ventricles of the brain, which results in progressive ventricular dilatation and an increased intracranial pressure. A ventriculoperitoneal shunt (VPS) is the most common treatment for hydrocephalus. Delayed development, behavioral dis... |
2,327,504 | Chemical Meningitis after a Golf Swing-induced Dermoid Cyst Rupture. | A 51-year-old man developed a sudden headache during golf practice, followed by a high fever. He was admitted with suspected neutrophilic meningitis and was diagnosed with chemical meningitis caused by a dermoid cyst rupture based on the characteristic magnetic resonance imaging (MRI) findings, which showed multiple li... |
2,327,505 | Immunoreactive Proteins in the Esophageal Gland Cells of Anisakis Simplex Sensu Stricto Detected by MALDI-TOF/TOF Analysis. | In plant and animal nematode parasites, proteins derived from esophageal gland cells have been shown to be important in the host-nematodes relationship but little is known about the allergenic potential of these proteins in the genus <i>Anisakis</i>. Taking into account the increase of anisakiasis and allergies related... |
2,327,506 | Medial temporal atrophy in preclinical dementia: Visual and automated assessment during six year follow-up. | Medial temporal lobe (MTL) atrophy is an important morphological marker of many dementias and is closely related to cognitive decline. In this study we aimed to characterize longitudinal progression of MTL atrophy in 93 individuals with subjective cognitive decline and mild cognitive impairment followed up over six yea... |
2,327,507 | Cognitive impairments in adult mice with RIP140 overexpression in neural stem cells. | Receptor-interacting protein 140 (RIP140) is a transcription co-regulator of several transcription factors and a signal transduction regulator. RIP140 was recently implicated in the regulation of cognitive functions. The gene that encodes RIP140 is located on chromosome 21. An increase in RIP140 expression was observed... |
2,327,508 | Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator. | In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage progression, we profiled >56,000 V-SVZ and OB cells by single-cell RNA sequencing (scRNA-seq). Our analyses reveal the molecular diversity of... |
2,327,509 | Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions. | To examine the impact of lesion location on longitudinal myelin water fraction (MWF) changes in chronic multiple sclerosis (MS) lesions. Relative hypoxia, due to vascular watershed regions of the cerebrum, has been implicated in lesion development but impact on ongoing demyelination is unknown.</AbstractText>Forty-eigh... |
2,327,510 | Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer's disease by elevating microRNA-15a and repressing ROCK1 expression. | Many studies have already suggested the role of long non-coding RNAs (lncRNAs) in Alzheimer's disease (AD), but the functions of lncRNA Taurine Upregulated Gene 1 (TUG1) in AD have been scarcely discussed. This study aims to verify how TUG1 affects hippocampal neurons in AD through modulation of microRNA-15a (miR-15a)/... |
2,327,511 | [Unilateral Transcranial Endoscopic Surgical Removal for Large Intraventricular Tumor Assisted by Contralateral Neuroendoscope]. | We report a case of a patient with large intraventricular tumor treated with craniotomy assisted by a neuroendoscope. A 25-year-old man, who had headache and nausea for several months, was transferred to our hospital with the diagnosis of an intraventricular tumor. Because of intracranial hypertension and hydrocephalus... |
2,327,512 | The Use of Descriptive Terms for Ventricular Size on Noncontrast Head CT Radiology Reports. | Multiple radiographic terms can be used to describe enlarged ventricles on noncontrast head computed tomography (CTs); however, precise terminology is important to determine etiology and clinical management. The purpose of this study was to characterize how ventricular size was described in radiology reports, especiall... |
2,327,513 | Endoscopic Fenestration of a Symptomatic Porencephalic Cyst in an Adult. | A porencephalic cyst is an aberrant accumulation of cerebrospinal fluid within the brain parenchyma. Its occurrence is rare, with an incidence of 3.5 per 100,000 live births. Etiology is considered the result of perinatal cerebral ischemia or hemorrhage, leading to parenchymal loss. Porencephalic cysts are diagnosed ra... |
2,327,514 | Lateral ventricular volume and calcarine sulcus depth: a fetal MRI analysis of mild ventriculomegaly: A STROBE compliant article. | The aim of this study was to quantify changes in the lateral ventricular volume, the depth of the calcarine sulcus (CS), and apparent diffusion coefficient (ADC) values of occipital lobe in fetuses with isolated mild ventriculomegaly (IMVM) using MRI.Seventy-one fetuses with IMVM at 25 to 38 weeks gestational age (GA) ... |
2,327,515 | Left ventricular diverticulum: incidental ÿ nding of a rare congenital cardiac abnormality.<Pagination><StartPage>166</StartPage><EndPage>167</EndPage><MedlinePgn>166-167</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4997/JRCPE.2020.220</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="... | Pulmonary Hypertension (PH) is a pathophysiological condition, defined by a mean pulmonary arterial pressure exceeding 25 mm Hg at rest, as assessed by right heart catheterization. A broad spectrum of diseases can lead to PH, differing in their etiology, histopathology, clinical presentation, prognosis, and respon... |
2,327,516 | Primary left ventricular neuroendocrine tumor in a middle-aged female: a case report. | Primary neuroendocrine tumors (NETs) in the heart are exceptionally rare. Here, we report a case found at our hospital of a 51-year-old woman with a primary left ventricular NET. The patient presented with non-causal recurrent diarrhea for 2 years, abdominal pain, and vomiting. Endoscopy revealed chronic proctitis and ... |
2,327,517 | Histological, molecular, clinical and outcomes characteristics of Multiple Lesion Glioblastoma. A retrospective monocentric study and review of literature. | Multiple lesion glioblastoma (M-GBM) represent a group of GBM patients in which there exist multiple foci of tumor enhancement. The prognosis is poorer than that of single-lesion GBM patients, but this actually is a controversial data. Is unknown whether multifocality has a genetic and molecular basis. Our specific aim... |
2,327,518 | Endoscopic management of pineal cyst-associated aqueductal stenosis. | The purpose of this study was to evaluate whether endoscopic third ventriculostomy (ETV) and endoscopic cyst fenestration are effective minimally invasive alternatives to a craniotomy with cyst resection for the treatment of symptomatic pineal cyst-associated aqueductal stenosis.</AbstractText>Sixteen patients with sym... |
2,327,519 | A novel approach to multiple anatomical shape analysis: Application to fetal ventriculomegaly. | Fetal ventriculomegaly (VM) is a condition in which one or both lateral ventricles are enlarged, and is diagnosed as an atrial diameter larger than 10 mm. Evidence of altered cortical folding associated with VM has been shown in the literature. However, existing works use a single scalar value such as diagnosis or... |
2,327,520 | Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules. | Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release into the cytosol are desired to achieve successful delivery. Focusing on compositional differences between the cell and endosomal membranes and the pH decrease w... |
2,327,521 | Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure. | Early gestational alcohol exposure is associated with severe craniofacial and CNS dysmorphologies and behavioral abnormalities during adolescence and adulthood. Alcohol exposure during the formation of the neural tube (gestational day [GD] 8 to 10 in mice; equivalent to4th week of human pregnancy) disrupts development ... |
2,327,522 | Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state. | Conflicting results have been reported in the association between glioblastoma proximity to the subventricular zone (SVZ) and enrichment of cancer stem cell properties. Here, we examined this hypothesis using magnetic resonance (MR) images derived from 217 The Cancer Imaging Archive (TCIA) glioblastoma subjects.</Abstr... |
2,327,523 | A case of medulloblastoma in a patient with fetal ventricular enlargement. | Medulloblastoma is the second-most common malignant tumor in children. Medulloblastoma has been categorized into four distinct molecular subgroups: WNT, sonic hedgehog (SHH), group 3, and group 4. We report on a male child with medulloblastoma, in whom an enlarged ventricle was diagnosed in utero. Magnetic resonance im... |
2,327,524 | The clinical treatment and outcome of cerebellopontine angle medulloblastoma: a retrospective study of 15 cases. | Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising in the cerebellum or the 4<sup>th</sup> ventricle. Cerebellopontine angle (CPA) MBs are extremely rare tumors, with few cases previously described. In this study, we sought to describe the clinical characteristics, molecular features and ou... |
2,327,525 | Human-specific <i>ARHGAP11B</i> increases size and folding of primate neocortex in the fetal marmoset. | The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene <i>ARHGAP11B</i> in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that <i>ARHGAP11B</i> c... |
2,327,526 | Dysautonomia secondary to third ventriculostomy successfully managed with midodrine. | Hypothalamic lesions can compromise its essential regulatory roles resulting in critical disruption of temperature and blood pressure homoeostasis. We present the case of a 55-year-old woman who had been previously submitted to several neurosurgical procedures aimed at treating idiopathic hydrocephalus. She presented t... |
2,327,527 | Neurogenesis and neuronal migration in the postnatal ventricular-subventricular zone: Similarities and dissimilarities between rodents and primates. | The ventricular-subventricular zone (V-SVZ) is located in the walls of the lateral ventricles and produces new neurons in the postnatal brain of mammals, including humans. Immature new neurons called "neuroblasts" generated by neural stem cells in the V-SVZ migrate toward their final destinations and contribute to brai... |
2,327,528 | Direct Inspection with Dual Endoscope Technique via Bilateral Transforaminal Approach Leading to Complete Resection of Recurrent Colloid Cyst of the Third Ventricle. | Although endoscopic approaches are widely used for resection of colloid cysts because of the lower invasiveness, removal of the recurrent colloid cyst is still challenging. Total removal is sometimes difficult to achieve with single-port endoscopy because of the restricted access and working space. To compensate for th... |
2,327,529 | Blast exposure predisposes the brain to increased neurological deficits in a model of blast plus blunt traumatic brain injury. | Soldiers are often exposed to more than one traumatic brain injury (TBI) over the course of their service. In recent years, more attention has been drawn to the increased risk of neurological deficits caused by the 'blast plus' polytrauma, which typically is a blast trauma combined with other forms of TBI. In this stud... |
2,327,530 | Discrepancy between ventricular and lumbar CSF in chronic meningitis. | Meningitis patient can present with various manifestation including hydrocephalus due to multiple reason. Diagnosis of meningitis mainly rely on CSF analysis which is usually obtained from lumbar puncture. In case of hydrocephalus CSF can be obtain from ventricles during VP shunt operation. Sometimes ventricular CSF ca... |
2,327,531 | Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia. | <b>Rationale:</b> Antenatal inflammation with placental dysfunction is strongly associated with high bronchopulmonary dysplasia (BPD) risk in preterm infants. Whether antenatal or postnatal HIF (hypoxia-inducible factor) augmentation can preserve lung structure and function and prevent pulmonary hypertension after intr... |
2,327,532 | Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract-a case study. | A case report of a 25-year-old man who committed suicide by intravenous injection himself of an aqueous home-made castor bean extract is presented. The patient was hospitalized and treated symptomatically and was released at its own request fourth day after intoxication. The next day, the patient's condition deteriorat... |
2,327,533 | Supratentorial intraventricular rosette-forming glioneuronal tumors - Case report and review of treatment paradigms. | Rosette-forming glioneuronal tumors (RGNT) are slow-growing WHO Grade I tumors that are characterized by mixed histology and rosette formation. Although typically located in the posterior fossa, these tumors can rarely originate elsewhere. Here, we describe the fourth case in literature where an RGNT was localized to t... |
2,327,534 | GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice. | Promoting axonal growth is essential for repairing damaged neuronal connections and motor function in spinal cord injury (SCI). Neuroleukin (NLK) exerts axonal growth activity <i>in vitro</i> and <i>in vivo</i>, but the mechanism remains unclear. This study reveals that the 78-kDa glucose-regulated protein (GRP78) is a... |
2,327,535 | Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex. | Viral infection during pregnancy has been suggested to increase the probability of autism spectrum disorder (ASD) in offspring via the phenomenon of maternal immune activation (MIA). This has been modeled in rodents. Maternal T helper 17 cells and the effector cytokine, interleukin 17A (IL-17A), play a central role in ... |
2,327,536 | Neuroimaging diagnosis of intraventricular Central neurocytoma. | To study the CT and MRI imaging manifestations of central and intraventricular central neurocytoma in the ventricle.</AbstractText>In this paper, 39 patients with central nervous cell tumour treated in our hospital from August 2015 to June 2018 were selected. All patients were performed plain CT scans using GE Highspee... |
2,327,537 | Transcallosal approach for intraventricular gliomas: neuropsychological outcome and functionality of the corpus callosum. | The transcallosal approach is commonly used for surgery of lateral and third ventricle lesions. Cognitive deficits due to the transcallosal approach still remain controversial. Even if enormous efforts have been made in order to understand specific functions of the corpus callosum, still little is known. The present st... |
2,327,538 | Ventriculo-peritoneal shunting devices for hydrocephalus. | Hydrocephalus is a common neurological disorder, caused by a progressive accumulation of cerebrospinal fluid (CSF) within the intracranial space that can lead to increased intracranial pressure, enlargement of the ventricles (ventriculomegaly) and, consequently, to brain damage. Ventriculo-peritoneal shunt systems are ... |
2,327,539 | Surgical approach to the posterior fossa in children, including anesthetic considerations and complications: The prone and the sitting position. Technical note. | Medulloblastoma (MB) in children is, in most cases, a midline lesion located in the posterior fossa, with a high tendency to invade the fourth ventricle (and sometimes its floor).</AbstractText>In this technical note, we present both the sitting and the prone position for children with medulloblastoma. These positions ... |
2,327,540 | Blood supply and arteriography of the pelvic limb of the Southern caracara (Caracara plancus) and great egret (Ardea alba). | The aim of this study was to compare the arterial vascularization of the pelvic limb between southern caracara (Caracara plancus) and great egret (Ardea alba) by dissection and radiographic examinations. Five specimens of caracaras (three males and two females), and seven great egrets (five males and two females) were ... |
2,327,541 | Nonreflecting Boundary Conditions for a CSF Model of Fourth Ventricle: Spinal SAS Dynamics. | In this paper, we introduce a one-dimensional model for analyzing the cerebrospinal fluid dynamics within the fourth ventricle and the spinal subarachnoid space (SSAS). The model has been derived starting from an original model of Linninger et al. and from the detailed mathematical analysis of two different reformulati... |
2,327,542 | The visual white matter connecting human area prostriata and the thalamus is retinotopically organized. | The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preference... |
2,327,543 | A novel de novo TSC2 nonsense mutation detected in a pediatric patient with tuberous sclerosis complex. | Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder characterized by hamartomas in multiple organ systems. The TSC1 and TSC2 genes have been identified as the genetic basis of TSC. Two gene tests were used for definitive genetic diagnosis.</AbstractText>In our study, the case of a Chinese ped... |
2,327,544 | Septo-optic dysplasia with fovea plana: A case report. | Septo-optic dysplasia (SOD) is characterized by optic nerve hypoplasia, pituitary gland hypoplasia, and midline abnormalities of the brain. The phenotype of SOD is highly heterogeneous, and the existence of at least two features is considered sufficient for diagnosis. Fovea plana is the absence of a foveal pit in the c... |
2,327,545 | Cisterns as Vital Structures: Byzantine Cisterns and Subarachnoid Cisterns. | Water is essential for life. It is needed not only to survive but also to sustain daily life activities. The maintenance of daily life activities related to hygiene as well as prevention of epidemic diseases and accidents involving fire was as important in the past as today. Powerful empires built many open-air and cov... |
2,327,546 | Human CNS barrier-forming organoids with cerebrospinal fluid production. | Cerebrospinal fluid (CSF) is a vital liquid, providing nutrients and signaling molecules and clearing out toxic by-products from the brain. The CSF is produced by the choroid plexus (ChP), a protective epithelial barrier that also prevents free entry of toxic molecules or drugs from the blood. Here, we establish human ... |
2,327,547 | Ventricular Volume Is More Strongly Associated with Clinical Improvement Than the Evans Index after Shunting in Idiopathic Normal Pressure Hydrocephalus. | Ventricular enlargement in idiopathic normal pressure hydrocephalus is often estimated using the Evans index. However, the sensitivity of the Evans index to estimate changes in ventricular size postoperatively has been questioned. Here, we evaluated the postoperative change in ventricle size in relation to shunt respon... |
2,327,548 | Neuroanatomical Changes in Leber's Hereditary Optic Neuropathy: Clinical Application of 7T MRI Submillimeter Morphometry. | Leber's hereditary optic neuropathy (LHON) is one of the mitochondrial diseases that causes loss of central vision, progressive impairment and subsequent degeneration of retinal ganglion cells (RGCs). In recent years, diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter t... |
2,327,549 | Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study. | Fetal growth restriction (FGR) is associated with neonatal and long-term neuro-morbidity. Preferential redistribution of blood flow to the brain is a common antenatal adaptation in FGR. The impact of this "brain sparing," which may signify severity of FGR, on the growth of brain structures has not been studied.</Abstra... |
2,327,550 | Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats. | Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work ... |
2,327,551 | Medial-tonsillar telovelar approach for resection of a superior medullary velum cerebral cavernous malformation: anatomical and tractography study of the surgical approach and functional implications. | Superior medullary velum cerebral cavernous malformations pose a challenge in terms of appropriate microsurgical approach. Safe access to this deep location as well as preservation of surrounding anatomical structures, in particular the superior cerebellar peduncle just lateral to the superior medullary velum and the d... |
2,327,552 | Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer's disease. | In Alzheimer's disease (AD) amyloid-β (Aβ) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood-cerebrospinal fluid (CSF) barrier. We previously carried out a mass proteomic-based study in choroid plexus from AD patients and we found several differentially re... |
2,327,553 | Training-Induced Deactivation of the AT<sub>1</sub> Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats. | The effects of hypertension and exercise training (T) on the sequential interplay between renin-angiotensin system (RAS), autonomic control and heart remodeling during the development of hypertension in spontaneously hypertensive rats (SHR), was evaluated.Methods and Results:Time course changes of these p... |
2,327,554 | The Fatal Case of an Autochthonous Heartworm Disease in a Dog from a Non-endemic Region of South-eastern Slovakia. | During the past few years, several localities with increasing <i>Dirofilaria immitis</i> occurrences have been identified in Slovakia; particularly in areas regarded as endemic for <i>Dirofilaria repens</i> up until now. In terms of that, dogs with clinically manifested heartworm disease have been referred to the veter... |
2,327,555 | Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons. | Pseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal fluids of critically ill patients. Introduction of these cytotoxic amyloids into the lateral ventricle impairs learning and memory in mice. However, it is uncle... |
2,327,556 | [Auxiliary Diagnostic Value of Tumor Markers in the Cerebrospinal Fluid and Blood for Leptomeningeal Metastasis from Non-small Cell Lung Cancer]. | 【中文题目：血清及脑脊液肿瘤标志物在非小细胞肺癌软脑膜转移辅助诊治中的价值】 【中... |
2,327,557 | Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma. | Tanycytes are highly specialized ependymal cells that line the bottom and the lateral walls of the third ventricle. In contact with the cerebrospinal fluid through their cell bodies, they send processes into the arcuate nucleus, the ventromedial nucleus, and the dorsomedial nucleus of the hypothalamus. In the present w... |
2,327,558 | Long-term Outcomes and Risk Factors Related to Hydrocephalus After Intracerebral Hemorrhage. | Hydrocephalus after intracerebral hemorrhage (ICH) is a common and treatable complication. However, the long-term outcomes and factors for predicting hydrocephalus have seldom been studied. The goal of this study was to determine the long-term outcomes and analyze the risk factors of hydrocephalus after ICH. A consecut... |
2,327,559 | Electrically stimulable indium tin oxide plate for long-term in vitro cardiomyocyte culture. | We investigated whether electrical stimulation via indium tin oxide (ITO) could enhance the in vitro culture of neonatal rat ventricular myocytes (NRVMs), which are important in vitro models for studying the mechanisms underlying many aspects of cardiology.</AbstractText>Cardiomyocytes were obtained from 1-day-old neon... |
2,327,560 | Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network. | Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca<sup>2+</sup>-permeable channelrhodopsin (CatCh) specific... |
2,327,561 | Autoradiography and inmmunolabeling suggests that lizard blastema contains arginase-positive M2-like macrophages that may support tail regeneration. | The regenerating blastema of the tail in the lizard Podarcis muralis contains numerous macrophages among the prevalent mesenchymal cells. Some macrophages are phagocytic but others are devoid of phagosomes suggesting that they have other roles aside phagocytosis.</AbstractText>The presence of healing macrophages (M2-li... |
2,327,562 | Risk stratification in patients hospitalized for acute heart failure in Asian population.<Pagination><StartPage>544</StartPage><EndPage>550</EndPage><MedlinePgn>544-550</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/JCMA.0000000000000340</ELocationID><Abstract><AbstractText Label="BACKGROUND" N... | The neurosphere assay is an extremely useful in vitro technique for studying the inherent properties of neural stem/progenitor cells (NSPCs) including proliferation, self-renewal and multipotency. In the postnatal and adult brain, NSPCs are mainly present in two neurogenic niches: the subventricular zone (SVZ) lining t... |
2,327,563 | Visualization of Mouse Choroidal and Retinal Vasculature Using Fluorescent Tomato Lectin Perfusion. | To develop a reliable and simplified method to assess choroid and retinal vasculature on whole mount and cross sections in mice using tomato lectin (TL; Lycopersicon esculentum</i>).</AbstractText>Albino mice (n</i> = 27) received 1 mg/mL of TL (conjugated to Dylight-594) intravascularly through the tail vein, jugular ... |
2,327,564 | GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop. | The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This neurotrophic factor was discovered in 1993 and shown to have selective effects on ... |
2,327,565 | Simultaneous single-trajectory endoscopic biopsy and third ventriculostomy in pediatric pineal region tumors. | Pineal region tumors have different pathological tumors and their optimal management remains controversial. Advancements in neuroendoscopy have led to the ability to simultaneously treat the hydrocephalus and obtain a tissue diagnosis. A retrospective review of 34 patients with pineal region tumors in Beijing Tiantan h... |
2,327,566 | The prognostic performance of brain ventricular characteristic differ according to sex, age, and time after cardiac arrest in comatose out-of-hospital cardiac arrest survivors. | We tested the consistency of ventricular characteristics measurement on brain computed tomography (CT) and investigated the prognostic performance of ventricular characteristics by sex, age, and time of brain CT in out-of-hospital cardiac arrest (OHCA) survivors.</AbstractText>We conducted a retrospective study of adul... |
2,327,567 | Neurofibromatosis type 1-related hydrocephalus: causes and treatment considerations. | The prevalence of hydrocephalus among patients with neurofibromatosis type I (NF1) is estimated to be between 1 and 13%. Most hydrocephalic causes are obstructive-aqueductal webs, chiasmatic-hypothalamic tumors, and thalamic mass effect related to NF changes. Other NF1-related conditions may mimic the clinical presenta... |
2,327,568 | Caregivers' evaluation of an educational material targeted to children with hydrocephalus. | Modern pediatric neurosurgery succeeded in reducing ventricle-peritoneal shunt malfunctions and shunt revisions. However, some children may be submitted to many surgeries, posing burden to their caregivers. And most of caregiver assume responsibility for care without emotional preparation. It is up to health profession... |
2,327,569 | Subependymal hyperintense layer on CISS sequence: An MRI study. | The present study aimed to explore the subependymal layers overlying the cerebral ventricles using magnetic resonance imaging.</AbstractText>A total of 69 outpatients underwent constructive interference in steady-state (CISS) sequence in thin-sliced, coronal, and sagittal sections.</AbstractText>The subependymal layers... |
2,327,570 | Spontaneous necrotizing granuloma of the cerebellum: a case report. | Intracranial necrotizing granulomatous space-occupying lesions are sparsely reported in literature. Variability in presenting symptomatology and radiographic features makes diagnostic work-up difficult.</AbstractText>This report presents the case of a 77-year-old female with sinusitis and fatigue who underwent an MRI r... |
2,327,571 | Central neurocytoma originating in third ventricle with expansion into the cerebral aqueduct and fourth ventricle: Case report and review of literature. | Central Neurocytomas (CNs) are rare brain tumors, making up less than 1% of all primary tumors within the CNS. They are commonly located in the lateral ventricles, and often present with visual changes and symptoms of obstructive hydrocephalus. Histopathology shows characteristics similar to ependymomas and oligodendro... |
2,327,572 | Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system. | Antenatal glucocorticoid therapy reduces mortality in the preterm infant, but evidence suggests off-target adverse effects on the developing cardiovascular system. Whether deleterious effects are direct on the offspring or secondary to alterations in uteroplacental physiology is unclear. Here, we isolated direct effect... |
2,327,573 | cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. | Advances in our understanding of the biological basis and molecular characteristics of ependymal tumors since the latest iteration of the World Health Organization (WHO) classification of CNS tumors (2016) have prompted the cIMPACT-NOW group to recommend a new classification. Separation of ependymal tumors by anatomic ... |
2,327,574 | [Factor analysis of cerebrospinal fluid spread in glioblastoma]. | <b>Objective:</b> To analyze the prognosis factors of cerebrospinal fluid (CSF) spread after surgery in glioblastoma (GBM) patients when tumors progressed and the effect factors on prognosis. <b>Methods:</b> A retrospective study was conducted on 124 patients who were pathologically diagnosed as glioblastoma after surg... |
2,327,575 | The slice score: A novel scale measuring intraventricular hemorrhage severity and predicting poor outcome following intracerebral hemorrhage. | To quantify extent of intraventricular hemorrhage (IVH) following intracerebral hemorrhage (ICH) with a novel, simple IVH severity score, and to explore and compare its performance in predicting worse outcomes.</AbstractText>A new scoring system for IVH severity was proposed and termed Slice score. The Slice score feat... |
2,327,576 | Complex Management of Hydrocephalus Secondary To Choroid Plexus Hyperplasia. | Hyperplasia of the choroid plexus represents a rare cause of communicating hydrocephalus in children. Recent work has associated such disease with genetic abnormalities (such as perturbations in chromosome 9). Given such extensive cerebrospinal fluid (CSF) overproduction, patients with choroid plexus hyperplasia often ... |
2,327,577 | A Prospective Cohort Study of Neural Progenitor Cell-Sparing Radiation Therapy Plus Temozolomide for Newly Diagnosed Patients With Glioblastoma. | In treating glioblastoma, irradiation of the neural progenitor cell (NPC) niches is controversial. Lower hippocampal doses may limit neurocognitive toxicity, but higher doses to the subventricular zones (SVZ) may improve survival.</AbstractText>To prospectively evaluate the impact of limiting radiation dose to the NPC ... |
2,327,578 | Impact of catheter-tissue contact force on lesion size during right ventricular outflow tract ablation in a swine model. | The catheter-tissue contact force (CF) is one of the significant determinants of lesion size and thus has a considerable impact on the effectiveness of ablation procedures. This study aimed to evaluate the impact of CF on the lesion size during right ventricular outflow tract (RVOT) ablation in a swine model.</Abstract... |
2,327,579 | Patient-specific Conditional Joint Models of Shape, Image Features and Clinical Indicators. | We propose and demonstrate a joint model of anatomical shapes, image features and clinical indicators for statistical shape modeling and medical image analysis. The key idea is to employ a copula model to separate the joint dependency structure from the marginal distributions of variables of interest. This separation p... |
2,327,580 | Parinaud syndrome as an unusual presentation of intracranial hypotension. | Vertical gaze palsy is a rare clinical manifestation of intracranial hypotension. The typical features of intracranial hypotension include a postural headache, dural enhancement, and low cerebrospinal fluid (CSF) opening pressure.</AbstractText>We describe a case of a shunt-dependent middle-aged female with aqueductal ... |
2,327,581 | Implication of image guidance in endoscopic third ventriculostomy: Technical note. | Endoscopic third ventriculostomy (ETV) is an advanced surgical procedure and plays a major role in the management of hydrocephalus. The complications associated with this procedure are grave and unforgiving. Image guidance system (IGS) can help reduce these complications. This technical note describes the technique for... |
2,327,582 | Improved Diagnostic Performance of New-generation 320-slice Computed Tomography with Forward-projected Model-based Iterative Reconstruction SoluTion for the Assessment of Late Enhancement in Left Ventricular Myocardium. | Objective Forward-projected Model-based Iterative Reconstruction SoluTion (FIRST) is a novel reconstruction method. We investigated the improvement in the diagnostic performance for the detection of abnormal late enhancement (LE) in left ventricular myocardium (LVM) using a new-generation 320-slice computed tomography ... |
2,327,583 | Transcranial Sonography Findings in Alzheimer's Disease: A New Imaging Biomarker. |  To validate transcranial sonography (TCS) as a novel imaging tool for the assessment of medial temporal lobe (MTL) atrophy (MTA).</AbstractText> Participants with Alzheimer's disease (AD, n = 30) and age-sex-matched controls (n = 30) underwent TCS and MRI. On TCS, MTL structur... |
2,327,584 | Experimentally Induced Cerebral Cystic Echinococcosis in Rats: A Suitable Animal Model for Cerebral Echinococcosis. | Echinococcus granulosus</i> is a worldwide zoonotic cestode that lives mainly in the intestine of dog as definitive host. Its larval stage infects intermediate hosts and forms hydatid cysts mainly in the liver and lungs tissues and less other organs such as brain, eye and bone. In the experimental models, inoculation o... |
2,327,585 | Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains. | Diabetes mellitus (DM) is now recognized as one of the risk factors for Alzheimer's disease (AD), and the disease-modifying effects of anti-diabetic drugs on AD have recently been attracting great attention. Sodium/glucose cotransporter 2 (SGLT2) inhibitors are a new class of anti-diabetic drugs targeting the SGLT2/sol... |
2,327,586 | Relationship Between Ablation Lesion Size Estimated by Ablation Index and Different Ablation Settings-an Ex Vivo Porcine Heart Study. | This study aimed to verify the reliability of ablation index (AI) for ablation lesion estimating with different settings for radiofrequency (RF) parameters: power, impedance, contact angles, irrigation rate, temperature of irrigation saline, and irrigation solution. RF ablations (N = 66) were performed on... |
2,327,587 | Hydrocephalus in infants: the unique biomechanics and why they matter. | Hydrocephalus diagnosed prenatally or in infancy differs substantially from hydrocephalus that develops later in life. The purpose of this review is to explore hydrocephalus that begins before skull closure and full development of the brain. Understanding the unique biomechanics of hydrocephalus beginning very early in... |
2,327,588 | Ependymal cells surface of human third brain ventricle by scanning electron microscopy. | The ependymal lining of the human brain ventricular system displays distinct structural differences and functional heterogeneity among individual ependymal cells (ECs). To date, multi-ciliated ECs (E1 cells), bi-ciliated ECs (E2 cells), uni-ciliated ECs (E3 cells), ECs without cilia, and ECs with cytoplasmic protrusion... |
2,327,589 | Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium. | The ventricular epithelium of the adult forebrain is a heterogeneous cell population that is a source of both quiescent and activated neural stem cells (qNSCs and aNSCs, respectively). We genetically targeted a subset of ventricle-contacting, glial fibrillary acidic protein (GFAP)-expressing cells, to study their invol... |
2,327,590 | Neuroanatomical alterations in higher-order thalamic nuclei of fetuses with Down syndrome. | Down syndrome (DS) is a genetic condition characterized by cognitive disability starting from infancy. Children with DS exhibit deficits in several cognitive domains, including executive function, i.e., a set of cognitive processes that heavily depend on higher-order thalamic nuclei. The goal of this study was to estab... |
2,327,591 | Morphometric characterization of collagen and fat in normal ventricular myocardium. | We used automated image analysis software to determine the proportion of collagen, fat, and myocytes across six histological regions of normal ventricular myocardium.</AbstractText>Twenty-nine non-cardiac death cases referred to our national cardiac pathology center were included in this study. Whole hearts were macros... |
2,327,592 | Impact of COVID-19 pandemic on ST-elevation myocardial infarction in a non-COVID-19 epicenter.<Pagination><StartPage>208</StartPage><EndPage>214</EndPage><MedlinePgn>208-214</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ccd.28997</ELocationID><Abstract><AbstractText Label="OBJECTIVES">We sough... | Invasive aspergillosis (IA) is one of the most common fungal infections among immunocompromised individuals. Despite the availability of antifungal drugs, IA can cause >50% mortality in infected immunocompromised patients. It is crucial to determine both host and pathogen factors that contribute to infection su... |
2,327,593 | Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure. | This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in anim... |
2,327,594 | Mirror-Image Lesions in Sequential Relapses of AQP4-Positive Neuromyelitis Optica Spectrum Disorder. | A 25 year-old Nigerian woman with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) presented with a 6 week history of nausea, vomiting, and refractory hiccups; as well as progressive lower extremity sensory loss, weakness, saddle anesthesia, and urinary incontinence. She had experienced her ... |
2,327,595 | Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice. | Non-coding RNA 886 (nc886/VTRNA2-1) is a Pol III transcript and an atypical imprinted gene. Its exact function as a negative regulator of protein kinase R establishes its connection with innate immunity. Studies have shown that nc886 silencing is closely associated with prostate cancer progression. Previous work has co... |
2,327,596 | Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric and adult population: a systematic review and meta-analysis. | Treatment options for hydrocephalus include endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS). Some ambiguity remains regarding indications, safety, and efficacy for these procedures in different clinical scenarios. The objective of the present study was to pool the available evidence to compa... |
2,327,597 | Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage. | Intraventricular hemorrhage is a common cause of morbidity and mortality in premature infants. The rupture of the germinal zone into the ventricles entails loss of neural stem cells and disturbs the normal cytoarchitecture of the region, compromising late neurogliogenesis. Here we demonstrate that neural stem cells can... |
2,327,598 | Arundic Acid (ONO-2506), an Inhibitor of S100B Protein Synthesis, Prevents Neurological Deficits and Brain Tissue Damage Following Intracerebral Hemorrhage in Male Wistar Rats. | Stroke is one of the leading causes of mortality and neurological morbidity. Intracerebral hemorrhage (ICH) has the poorest prognosis among all stroke subtypes and no treatment has been effective in improving outcomes. Following ICH, the observed high levels of S100B protein have been associated with worsening of injur... |
2,327,599 | Long-Term Outcomes of Sporadic Vestibular Schwannomas Treated with Recent Stereotactic Radiosurgery Techniques. | Vestibular schwannomas (VSs) are benign; thus, understanding long-term tumor control and late adverse radiation effects of stereotactic radiosurgery (SRS) through current radiosurgical techniques is important to inform treatment decisions. Our aim was to clarify long-term tumor control rates and incidence of late adver... |
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