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2,331,800 | Effect of various dialysis modalities on intradialytic hemodynamics, tissue injury and patient discomfort in chronic dialysis patients: design of a randomized cross-over study (HOLLANT). | From a recent meta-analysis it appeared that online post-dilution hemodiafiltration (HDF), especially with a high convection volume (HV-HDF), is associated with superior overall and cardiovascular survival, if compared to standard hemodialysis (HD). The mechanism(s) behind this effect, however, is (are) still unclear. ... |
2,331,801 | Cardiomyocyte heterogeneity during zebrafish development and regeneration. | Contrary to adult mammals, zebrafish are able to regenerate their heart after cardiac injury. This regenerative response relies, in part, on the endogenous ability of cardiomyocytes (CMs) to dedifferentiate and proliferate to replenish the lost muscle. However, CM heterogeneity and population dynamics during developmen... |
2,331,802 | Evaluating Left Ventricular Systolic Synchronicity with Real-Time 3D Echocardiography in Newborns. | Knowing the normal values of left ventricular (LV) systolic synchronicity in the early neonatal period is very important for understanding myocardial function. This retrospective study analyzed data of 105 newborns who were examined using real-time 3-dimensional echocardiography (RT3DE). The time to the point of minima... |
2,331,803 | Transfer of Patients with Spontaneous Intracranial Hemorrhage who Need External Ventricular Drain: Does Admission Location Matter? | Patients with spontaneous intracranial hemorrhage (sICH) are associated with high mortality and require early neurosurgical interventions. At our academic referral center, the neurocritical care unit (NCCU) receives patients directly from referring facilities. However, when no NCCU bed is immediately available, patient... |
2,331,804 | A case report of Arnold Chiari type 1 malformation in acromesomelic dwarf infant. | Arnold Chiari malformation is one of the commonest cause of congenital hydrocephalus. Cause of fetal development of cerebellar tonsils remains unknown and may be diagnosed at later in life. The association of Arnold Chiari malformation with acromesomelic dwarfism is not known. We report male infant diagnosed with acrom... |
2,331,805 | Quadrigeminal cistern arachnoid cyst as a probable cause of hemifacial spasm. | Arachnoid cysts arising in the quadrigeminal cistern (ACQCs) are uncommon. A 68-year-old woman presented with an unsteady gait, facial spasm, and cerebellar ataxia. Non-contrast head computed tomography showed a cystic mass centered in the quadrigeminal cistern accompanying ventriculomegaly. On MRI, the cyst appeared h... |
2,331,806 | AIF3 splicing switch triggers neurodegeneration. | Apoptosis-inducing factor (AIF), as a mitochondrial flavoprotein, plays a fundamental role in mitochondrial bioenergetics that is critical for cell survival and also mediates caspase-independent cell death once it is released from mitochondria and translocated to the nucleus under ischemic stroke or neurodegenerative d... |
2,331,807 | Left ventricular diastolic dysfunction and diseases severity contribute to impaired exercise capacity in systemic lupus erythematosus. | Patients with systemic lupus erythematosus (SLE) have a higher risk of myocardial involvement, which can result in ventricular dysfunction. The aim of our study was to estimate potential relationship between exercise capacity assessed by six minute walk test (6MWT) and echocardiographic parameters of left and right ven... |
2,331,808 | Effects of taxol on neuronal differentiation of postnatal neural stem cells cultured from mouse subventricular zone. | Taxol (paclitaxel), a chemotherapeutic agent for several cancers, can adversely affect the peripheral nervous system. Recently, its negative impact on cognitive function in cancer patients has become evident. In rodents, taxol impaired learning and memory, with other possible negative effects on the brain. In this stud... |
2,331,809 | Primary cardiac tumours: how well can prenatal diagnosis "predict" postnatal outcome? | Primary foetal cardiac tumours are rare congenital malformations. They can cause a flow obstruction, arrhythmias and can lead to cardiac failure, hydrops or death. Postnatal management is based on patient´s clinical and hemodynamic impairment.</AbstractText>We retrospectively reviewed data from 2009-2019 from our ... |
2,331,810 | The benefits of inferolateral transtubercular route on intradural surgical exposure using the endoscopic endonasal transclival approach. | Surgical access to the ventral pontomedullary junction (PMJ) can be achieved through various corridors depending on the location and extension of the lesion. The jugular tubercle (JT), a surgically challenging obstacle to access the PMJ, typically needs to be addressed in transcranial exposures. We describe the endosco... |
2,331,811 | CT findings and the prognostic value of the Koret CT score in cats with traumatic brain injury. | The aims of this study were to evaluate associations between abnormal head CT findings and outcome, and to examine the prognostic value of the Koret CT score (KCTS) in cats sustaining acute traumatic brain injury (TBI).</AbstractText>The medical records of cats hospitalised with TBI that underwent head CT scans within ... |
2,331,812 | Position of the choroid plexus of the fourth ventricle in first- and second-trimester fetuses: a novel approach to early diagnosis of cystic posterior fossa anomalies. | To describe the sonographic appearance and position of the choroid plexus of the fourth ventricle (4V-CP) between 12 and 21 weeks' gestation in normal fetuses and in fetuses with Dandy-Walker malformation (DWM) or Blake's pouch cyst (BPC).</AbstractText>The study population comprised 90 prospectively recruited n... |
2,331,813 | Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure. | SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozin (EMPA) inhibits proximal tubule ... |
2,331,814 | Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. | Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this stru... |
2,331,815 | Cardiac Fibroblasts and Myocardial Regeneration. | The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue. Although the majority... |
2,331,816 | MRI imaging findings in prune perineum syndrome: an extremely rare entity. | We report a case of prune perineum syndrome, an extremely rare entity with only four cases reported to date, describing some typical clinical and radiologic features. We also present a newly associated imaging finding, the terminal ventricle's cystic dilatation, and briefly discuss the differential diagnosis. |
2,331,817 | Unintentional direct intraventricular injection of gadolinium with fatal outcome: report of a case. | Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) is the main contrast agent used in MRI, known for its good tolerance and rare toxicity. Even intrathecal injection of limited doses of Gadolinium can be performed in some indications. To our knowledge, only 3cases of accidental intraventricular injection of Gado... |
2,331,818 | Carotid endarterectomy under regional analgesia:a retrospective study (1988-1999). | The procedure of carotid endarterectomy is more or less standardized. Controversies persist on many technical issues, one of which is general versus regional anaesthesia. We retrospectively evaluated the influence of regional analgesia on perioperative complications, the hospital stay and the perioperative mortality af... |
2,331,819 | Recent advances in thyroid research: selective thyroid hormone receptor modulators (STRMs). | Compounds have been designed and tested exhibiting some of the beneficial effects of thyroid hormones, such as lowering of cholesterol and weight reduction, without the adverse thyroid hormone action on heart rate. Progress has also been made in attempting to treat hyperthyroidism by synthesizing antagonists that block... |
2,331,820 | How to write a paper for publication. | Engaging in the scientific publication process can be for both altruistic and egotistical reasons; publication advances the state of scientific knowledge while advancing your institution and your career. Writing for publication means setting aside a location and time dedicated entirely to the process of planning and wr... |
2,331,821 | Lumbar plexus blockade with ropivacaine for postoperative pain management in elderly patients undergoing urologic surgeries. | <AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">We evaluated the effectiveness and safety of lumbar plexus blockade with ropivacaine for postoperative pain relief in elderly patients undergoing flank incision for urological surgery.</AbstractText>60 urological patients (>65 years old) were chosen rando... |
2,331,822 | Stellate ganglion block inhibits formalin-induced nociceptive responses: mechanism of action.<Pagination><StartPage>913</StartPage><EndPage>918</EndPage><MedlinePgn>913-8</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Stellate ganglion block has been extensivel... | The study was undertaken to evaluate the effectiveness and safety of ropivacaine used via long-term epidural infusion and to define the optimum doses of the agent in the intra- and postoperative period. The parameters of hemodynamics, the adequacy of anesthesia, and the consumption of the agent were explored in 53 pati... |
2,331,823 | HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice. | HIV-1 Nef has the ability to downmodulate CD4 cell surface expression. Several studies have shown that CD4 downregulation is required for efficient virus replication and high infectivity. However, the pathophysiological relevance of this phenomenon in vivo, independently of its role in sustaining high virus loads, rema... |
2,331,824 | Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. | Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong to the superfamily of G-protein-coupled receptors (GPCRs). So far, the P2Y family is composed out of 8 human subtypes that have been cloned a... |
2,331,825 | Effect of concrete block weight and wall height on electromyographic activity and heart rate of masons. | Work-related musculoskeletal disorders (MSDs) are common among construction workers, such as masons. Few interventions are available to reduce masons' exposure to heavy lifting, a risk factor for MSDs. The purpose of this study was to determine whether one such intervention, the use of light-weight concrete blocks (LWB... |
2,331,826 | General anesthesia and the neural correlates of consciousness. | The neural correlates of consciousness must be identified, but how? Anesthetics can be used as tools to dissect the nervous system. Anesthetics not only allow for the experimental investigation into the conscious-unconscious state transition, but they can also be titrated to subanesthetic doses in order to affect selec... |
2,331,827 | Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? | To calculate treatment plans and compare the dose distributions and dose-volume histograms (DVHs) for photon three-dimensional conformal radiation therapy (3D-CRT), electron therapy, intensity-modulated radiation therapy (IMRT), and standard (nonintensity modulated) proton therapy in three pediatric disease sites.</Abs... |
2,331,828 | Pregnancy outcome in patients with primary Sjögren's syndrome. a case-control study. | To study the outcome of pregnancy in patients with primary Sjögren's syndrome (pSS).</AbstractText>A questionnaire covering demographic data and the outcome of pregnancies was answered by 58 patients with pSS and 157 controls. For 36 patients and 93 controls, we analyzed detailed data about pregnancy, birth, and s... |
2,331,829 | Cortical activation during Pavlovian fear conditioning depends on heart rate response patterns: an MEG study. | In the present study, we examined stimulus-driven neuromagnetic activity in a delayed Pavlovian aversive conditioning paradigm using steady state visual evoked fields (SSVEF). Subjects showing an accelerative heart rate (HR) component to the CS+ during learning trials exhibited an increased activation in sensory and pa... |
2,331,830 | The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: a randomized controlled trial. | The purpose of this research was to study the effects on the physiologic pain response of the neonate during circumcision with the use of a gloved human finger.</AbstractText>This was a randomized controlled trial analyzing the effect of non-nutritive sucking (NNS) on pain response during circumcision. Term neonates we... |
2,331,831 | The mechanism of naked DNA uptake and expression. | The administration of naked nucleic acids into animals is increasingly being used as a research tool to elucidate mechanisms of gene expression and the role of genes and their cognate proteins in the pathogenesis of disease in animal models (Herweijer and Wolff, 2003; Hodges and Scheule, 2003). It is also being used in... |
2,331,832 | Gata4 regulates the formation of multiple organs. | We have developed a loss-of-function model for Gata4 in zebrafish, in order to examine broadly its requirement for organogenesis. We show that the function of Gata4 in zebrafish heart development is well conserved with that in mouse, and that, in addition, Gata4 is required for development of the intestine, liver, panc... |
2,331,833 | Clinical characteristics and treatment of short QT syndrome.<Pagination><StartPage>611</StartPage><EndPage>617</EndPage><MedlinePgn>611-7</MedlinePgn></Pagination><Abstract><AbstractText>Short QT syndrome is a new inherited disorder associated with familial atrial fibrillation and/or sudden death or syncope. To date, t... | Short QT syndrome is a new inherited disorder associated with familial atrial fibrillation and/or sudden death or syncope. To date, three different mutations in genes encoding cardiac ion channels (KCNH2, KCNQ1 and KCNJ2) have been identified as causing short QT syndrome. All mutations lead to a gain in function of the... |
2,331,834 | Induction of compulsive-like washing by blocking the feeling of knowing: an experimental test of the security-motivation hypothesis of obsessive-compulsive disorder. | H. Szechtman and E. Woody (2004) hypothesized that obsessive-compulsive disorder results from a deficit in the feeling of knowing that normally terminates thoughts or actions elicited by security motivation. To test the plausibility of this proposed mechanism, an experiment was conducted to produce an analog of washing... |
2,331,835 | Single-shot spinal block for labour analgesia in multiparous parturients*. | Intrathecal analgesia (ITA) is effective in late, rapidly progressing labour. In 1998, our hospital implemented the use of single-shot spinal block for pain relief in multiparous parturients. As part of a quality assurance programme, we assessed the analgesic efficacy, obstetric and neonatal outcomes and maternal satis... |
2,331,836 | Indomethacin-loaded methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic diblock copolymeric nanospheres: pharmacokinetic and toxicity studies in rodents. | Biodegradable methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic block copolymeric nanospheres were prepared for application as a particulate drug carrier. Drug-loaded nanospheres (ML50) showed a narrow size distribution with the average diameter of <200 nm. When the feed weight ratio of indomethacin (IMC) ... |
2,331,837 | The 1926 General Hospital, Singapore. | This article mentions briefly the history of the early General Hospitals of Singapore, and the events leading to the opening of the 1926 General Hospital (the predecessor of the present General Hospital). There is a detailed description of this hospital. During the next four decades there were many changes (alterations... |
2,331,838 | Focal seizures as an unusual presentation of neonatal lupus erythematosus. | Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatob... |
2,331,839 | Randomized controlled trial of music during kangaroo care on maternal state anxiety and preterm infants' responses. | The purpose of this randomized controlled trial was to investigate the influences of music during kangaroo care (KC) on maternal anxiety and preterm infants' responses. There are no experimental studies that explore the influences of combination of music and KC on psychophysiological responses in mother-infant dyads. P... |
2,331,840 | Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52. | Ro52 is one of the major autoantigens targeted in the autoimmune disease Sjögren syndrome. By sequence similarity, Ro52 belongs to the RING-B-box-coiled-coil (RBCC) protein family. Disease-related antibodies bind Ro52 in a conformation-dependent way both in the coiled-coil region and in the Zn2+-binding Ring-B-box... |
2,331,841 | Bax translocates from cytosol to mitochondria in cardiac cells during apoptosis: development of a GFP-Bax-stable H9c2 cell line for apoptosis analysis. | The proapoptotic protein Bax plays an important role in cardiomyocytic cell death. Ablation of this protein has been shown to diminish cardiac damage in Bax-knockout mice during ischemia-reperfusion. Presently, studies of Bax-mediated cardiac cell death examined primarily the expression levels of Bax and its prosurviva... |
2,331,842 | State anxiety and affective physiology: effects of sustained exposure to affective pictures. | Effects of sustained exposure to emotional stimuli on affective reactions and their recovery were examined to determine whether increasing exposure to a specific emotional content (e.g., unpleasant) cumulatively affects physiological responses; and whether motivational activation persists following sustained exposure. ... |
2,331,843 | The experience of SARS-related stigma at Amoy Gardens. | Severe Acute Respiratory Syndrome (SARS) possesses characteristics that render it particularly prone to stigmatization. SARS-related stigma, despite its salience for public health and stigma research, has had little examination. This study combines survey and case study methods to examine subjective stigma among reside... |
2,331,844 | Use of levobupivacaine for the treatment of postoperative pain after thoracotomies. | Continuous thoracic epidural analgesia with an opiod-local anaesthetic mixture is the most appropriate strategy to control postoperative pain in thoracic surgery. Levobupivacaine, the pure S(-) enantiomer of racemic bupivacaine, has less cardiotoxic and neurotoxic potential but similar anaesthetic properties of its nat... |
2,331,845 | Central blocks with levobupivacaina in children. | Regional anesthesia has become a routine practice in paediatric anesthesia and local anaesthetics are now widely used in infants and children. Although local anaesthetics are generally quite safe and effective, they may produce systemic toxic reactions affecting the heart and brain. Because postoperative analgesia is o... |
2,331,846 | Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo. | Regulatory T cells (Tregs) are increasingly recognized as playing a major role in nondeletional tolerance. To avoid rejection before tolerance is established, clinical trials of tolerance induction include immunosuppressive drugs early posttransplant. It is therefore essential that immunosuppressive protocols do not bl... |
2,331,847 | Selective agonists and antagonists to thyroid hormone action. | Selective thyromimetics have been designed and shown to exhibit some of the beneficial effects of thyroid hormones, such as lowering of cholesterol and weight reduction, without the adverse thyroid hormone action on muscle, bone, and heart rate. Progress has also been made in attempting to treat hyperthyroidism by synt... |
2,331,848 | [Development of a portable ECG monitor with diagnostic & therapeutic functions and its clinical applications].<Pagination><StartPage>13</StartPage><EndPage>37</EndPage><MedlinePgn>13-6, 37</MedlinePgn></Pagination><Abstract><AbstractText>A portable ECG monitor is introduced in the paper, which has a temporary intra... | A portable ECG monitor is introduced in the paper, which has a temporary intravenous and transesophageal fixable rate pacing function. During the PSVT attack, the tachyarrythmia can be stopped by the transesophageal cardiac pacing while the ECG signals are monitored. The instrument has some advantages such as small siz... |
2,331,849 | Developmental role of GnRH and PACAP in a zebrafish model. | GnRH is expressed early in development long before reproduction begins. To determine whether GnRH has a role in development, gene knockdown with morpholinos was used in one-cell zebrafish embryos to block translation of gnrh mRNA into protein. Gene knockdown of gnrh2, gnrh3 or both at the one-cell stage resulted in a h... |
2,331,850 | [Cardiovascular response caused by intracerebroventricular microinjection of interleukin-2]. | To investigate the cardiovascular response caused by intracerebroventricular (ICV) microinjection of interleukin-2 (IL-2) and explore the underlying mechanism.</AbstractText>Male Sprague-Dawley rats were anesthetized with intraperitoneal urethane( 1.2 g/ kg). The changes of mean arterial blood pressure (MAP) and heart ... |
2,331,851 | Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. | Dopamine given at moderate doses for inotropy to postischemic hearts has been shown to augment myocyte apoptosis in association with elevated cytosolic calcium. We hypothesize that dopamine-mediated apoptosis occurs through calcium-induced opening of the mitochondrial permeability transition (mPT) pore. We also hypothe... |
2,331,852 | Long-term effects of proglumide on resection of cardiac adenocarcinoma. | Patients with advanced stage cardiac adenocarcinoma have a very poor prognosis. Surgery is the first choice of treatment for this kind of patients. Peptide hormone gastrin is a recognized growth factor for gastric cancer, and gastrin receptor antagonist proglumide can block the effects of gastrin. The aim of this study... |
2,331,853 | Intrauterine diagnosis and treatment of a concordant complete heart block in a twin pregnancy.<Pagination><StartPage>523</StartPage><EndPage>525</EndPage><MedlinePgn>523-5</MedlinePgn></Pagination><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hofstetter</LastName><ForeName>G</ForeName><Initials>G</Initials><... | Acute coronary syndrome (ACS) includes acute myocardial infarction and unstable angina. ACS is common and may prove fatal. Hyperbaric oxygen therapy (HBOT) will improve oxygen supply to the threatened heart and may reduce the volume of heart muscle that will perish. The addition of HBOT to the standard treatment may re... |
2,331,854 | Comparison of three modes of patient-controlled epidural analgesia during labour. | This study compares three modes of patient-controlled epidural analgesia in parturients during labour.</AbstractText>Eighty-four women were randomized to one of three groups. The epidural solution used in all the three groups was 0.1% bupivacaine with fentanyl 2 microg mL(-1). Patients were able to self administer a de... |
2,331,855 | Bupivacaine versus L-bupivacaine for labor analgesia via combined spinal-epidural: a randomized, double-blinded study. | To compare the intensity and duration of motor block and the duration of sensory block with racemic bupivacaine and l-bupivacaine for combined spinal-epidural analgesia, as previous studies have shown contradictory results.</AbstractText>A prospective, randomized, double-blinded study.</AbstractText>Birth Center at Mag... |
2,331,856 | Radial dilation force of tipless and helical stone baskets.<Pagination><StartPage>946</StartPage><EndPage>947</EndPage><MedlinePgn>946-7</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate one aspect of tipless and helical stone basket function that is critical for urete... | Salvo impulses on the vagus nerve of a cat with a varying in each cardiocycle interval after ECG P wave led to recurrent variations of ECG interval P-P manifesting as sinus arrhythmia. A chronotropic effect of the vagus nerve experienced moderate changes in dislocation of the vagus stimulus position in the beginning of... |
2,331,857 | [Unilateral spinal anaesthesia in elderly patient for hip trauma: a pilot study]. | Fractured neck of femur is encountered more frequently as life expectancy increases. All anaesthetic techniques aim to avoid deleterious fall in arterial blood pressure. The haemodynamic effects of hypobaric unilateral spinal anaesthesia have been rarely assessed in patients over 80 year's old. This study aims to do th... |
2,331,858 | [The para-umbilical block in children: 75 cases report]. | The objective of this study is to assess both intra and post operative analgesia in infants undergoing umbilical hernia repair under general anaesthesia with neither opioid nor muscle relaxant, associated with a para umbilical block. It's a prospective study covering a 15 months period. The study included 75 infants (a... |
2,331,859 | sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. | The sigma receptors have been implicated in the regulation of the cardiovascular system, and sigma-1 receptor transcripts have been found in parasympathetic intracardiac neurons. However, the cellular function of sigma-1 receptors in these cells remains to be determined. Effects of sigma receptor activation on voltage-... |
2,331,860 | TNF antagonists for ankylosing spondylitis. | Up to 2 in 1,000 adults in the UK have ankylosing spondylitis. This chronic inflammatory disease causes pain and stiffness in the spine and sacroiliac and peripheral joints, and may also affect the eyes, heart and ungs. Characteristic features include ankylosis of the spine with a progressive loss of spinal mobility. T... |
2,331,861 | Rapid injection of epidural mepivacaine speeds the onset of nerve blockade. | When used intraoperatively, mepivacaine can produce a satisfactory sensory block. However, insufficient information is available concerning the factors that affect the speed of nerve blockade with epidural analgesia. The optimal rate of injection of mepivacaine has not been determined. We examined whether the speed of ... |
2,331,862 | Preoperative caudal block prevents emergence agitation in children following sevoflurane anesthesia. | The frequency of emergence agitation in children is increased following sevoflurane anesthesia. However, controversies still exist concerning the exact etiology of this postanesthetic problem. Although this phenomenon is present with adequate pain relief or even following pain-free procedures, pain is still regarded as... |
2,331,863 | Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction. | Tissue induction during embryonic development relies to a significant degree on the integration of combinatorial regulatory inputs at the enhancer level of target genes. During mesodermal tissue induction in Drosophila, various combinations of inductive signals and mesoderm-intrinsic transcription factors cooperate to ... |
2,331,864 | Block of inactivation-deficient cardiac Na(+) channels by acetyl-KIFMK-amide. | The Na(+) channel alpha-subunit contains an IFM motif that is critical for the fast inactivation process. In this study, we sought to determine whether an IFM-containing peptide, acetyl-KIFMK-amide, blocks open cardiac Na(+) channels via the inner cavity. Intracellular acetyl-KIFMK-amide at 2mM elicited a rapid time-de... |
2,331,865 | Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the Kv4 family. | Kv4 voltage-gated K(+) channels are responsible for transient K(+) currents in the central nervous system and in the heart. HpTx2 is a peptide toxin that selectively inhibits these currents; making it a useful probe for understanding Kv4 channel structure and drug binding. Therefore, we developed a method to produce la... |
2,331,866 | A comparison of median effective doses of intrathecal levobupivacaine and ropivacaine for labor analgesia. | The study was designed to determine and compare the median effective doses (MEDs) of intrathecal ropivacaine with levobupivacaine for labor analgesia.</AbstractText>In this double-blind study, 100 parturients in early labor were randomized to receive either intrathecal ropivacaine or levobupivacaine. For each drug, the... |
2,331,867 | Cardiac arrest during neuraxial anesthesia: frequency and predisposing factors associated with survival. | The frequency and predisposing factors associated with cardiac arrest during neuraxial anesthesia remain undefined, and the survival outcome data are contradictory. In this retrospective study, we evaluated the frequency of cardiac arrest, as well as the association of preexisting medical conditions and periarrest even... |
2,331,868 | [Early results of surgical treatment in acquired heart diseases during endocarditis in own material].<Pagination><StartPage>623</StartPage><EndPage>626</EndPage><MedlinePgn>623-6</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Endocarditis can concern natural as well as arti... | Finoptin and obzidane influence on morphologic signs of intact ventricular cardiac hystiocytes has been examined during the experiments on animals by means of the complex of histological and histochemical methods, electron microscopy as well as morphometry. It has been established that long-term using of finoptin and o... |
2,331,869 | [Advantage of ropivacaine for postoperative epidural analgesia following leg orthopedic surgery]. | Epidural administration of local anesthetics may lead to effective pain relief. However, tachyphylaxis or other problems following prolonged epidural anesthesia may develop and in many cases difficulties exist in the maintenance of the similar degree of sensory blockade. The present study was therefore performed to inv... |
2,331,870 | Bolus injection of Ringer's solution and dextran 1 kDa during induction of spinal anesthesia. | Arterial hypotension following induction of spinal anesthesia is difficult to prevent with infusion fluids. In a randomized, unblinded and controlled study we evaluated whether a rapid fluid administration planned according to volume kinetic analysis is followed by a more stable blood pressure.</AbstractText>Spinal ane... |
2,331,871 | Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy. | The myocytes of the adult mammalian heart are considered unable to divide. Instead, mitogens induce cardiomyocyte hypertrophy. We have investigated the effect of adenoviral overexpression of cyclin D2 on myocyte proliferation and morphology. Cardiomyocytes in culture were identified by established markers. Cyclin D2 in... |
2,331,872 | Massive myocardial calcification in second-trimester fetuses: antenatal detection and causes. | Massive myocardial calcifications were detected by antenatal ultrasound examination in four second-trimester fetuses. In one fetus, multiple cardiac rhabdomyomas were the initial diagnosis. One fetus presented with arthrogryposis and the brain and spinal cord showed severe hypoxic-ischemic damage. One fetus was hydropi... |
2,331,873 | 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. | This study was carried out to determine the effect of 2-aminoethoxydiphenyl borate (2-APB), a common activator of transient receptor potential vanilloid (TRPV) type 1, 2, and 3 channels, on cardiorespiratory reflexes, pulmonary C fiber afferents, and isolated pulmonary capsaicin-sensitive neurons. In anesthetized, spon... |
2,331,874 | IL-1beta in bronchial lavage fluid is a non-invasive marker that predicts the viability of the pulmonary graft from the non-heart-beating donor. | Viability testing of the pulmonary graft retrieved from the non-heart-beating donor (NHBD) is mandatory for successful outcome after lung transplantation. Functional assessment by ex vivo reperfusion, however, remains a cumbersome procedure. In this study, therefore, we wanted to investigate the possible value of the p... |
2,331,875 | Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. | Tolerogenic properties of dendritic cells (DC), particularly those in the immature state, and their therapeutic potential are increasingly being recognized. Among several distinct approaches to generate stably immature DC, pharmacologic manipulation stands out as a promising and clinically applicable option. We have sh... |
2,331,876 | Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? | The aim of the our study was to investigate the role of adenosine receptors on cardiovascular toxicity induced by amitriptyline, a tricyclic antidepressant agent. Therefore, the hypothesis of this study was that adenosine receptor antagonists would improve and/or prevent amitriptyline-induced hypotension and conduction... |
2,331,877 | Identification of out-of-hospital cardiac arrest clusters using a geographic information system. | To locate all out-of-hospital cardiac arrests (OHCAs) in Rochester, New York, and identify clusters of OHCAs, as well as clusters of patients who did not receive bystander cardiopulmonary resuscitation (CPR), in order to identify locations that may benefit from prevention efforts.</AbstractText>The locations of all adu... |
2,331,878 | Facial telangiectasia-an unusual complication of neonatal lupus erythematosus: report of one case. | Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalitie... |
2,331,879 | Continuous thoracic epidural anesthesia induces segmental sympathetic block in the awake rat. | Thoracic epidural anesthesia (TEA) is used increasingly in critical care, especially for cardiac and intestinal sympathetic block. In this study we evaluated cardiorespiratory function and sympathetic activity in a new model of continuous TEA in awake rats. Thirteen rats received epidural saline control (CON) or bupiva... |
2,331,880 | Epidural analgesia for childbirth: effects of newer techniques on neonatal outcome. | New low-dose, local anesthetic-opioid combinations, combined spinal epidural analgesia, and new anesthetic drugs, such as ropivacaine and levobupivacaine, have modified the anesthetic practice in obstetric labor analgesia. These new analgesic techniques have less or no neonatal effects when compared with traditional ep... |
2,331,881 | Pain control with low-dose alfentanil in children undergoing minor abdominal and genito-urinary surgery. | The aim of this study was to investigate the quality of intra- and postoperative analgesia obtained by alfentanil compared to that produced by peripheral blockade in children.</AbstractText>During sevoflurane-nitrous oxide atracurium anaesthesia for minor abdominal or genito-urinary surgery, three groups of children ag... |
2,331,882 | Case reports. 1. An autopsy case of fatal arrhythmia induced by injuries of the atrioventricular conduction system: a case report.<Pagination><StartPage>353</StartPage><EndPage>358</EndPage><MedlinePgn>353-8</MedlinePgn></Pagination><Abstract><AbstractText>A 65-year-old woman died three days after being involved in a t... | A 65-year-old woman died three days after being involved in a traffic accident, following an episode of ventricular fibrillation. She was diagnosed as having suffered cardiac contusion, liver contusion, mediastinal hematoma and rib fracture on admission. Her electrocardiogram showed complete right bundle branch block, ... |
2,331,883 | [Accidental subarachnoid steroid injection during chronic lumbar pain treatment: case report.]. | Before epidural steroids were used in chronic lumbar pain, subarachnoid injection of these agents was the treatment of choice. Although still preconized by some authors, this technique may lead to severe complications with neurological sequelae. This report aimed at describing a case of accidental subarachnoid injectio... |
2,331,884 | Anti-52 kDa Ro, anti-60 kDa Ro, and anti-La antibody profiles in neonatal lupus. | Studies suggest that anti-52 kDa Ro antibodies are more sensitive and specific than anti-60 kDa Ro antibodies for neonatal lupus. However, these studies mainly used immunoblot or ELISA using recombinant protein, which have poor sensitivity for anti-60 kDa Ro antibodies. In addition, the control patients were not diseas... |
2,331,885 | Evaluation of genitofemoral nerve block, in addition to ilioinguinal and iliohypogastric nerve block, during inguinal hernia repair in children. | Ilioinguinal and iliohypogastric (IG-IH) nerve block has been widely used in children undergoing inguinal hernia repair. This technique may provide insufficient analgesia for intraoperative management as the inguinal region may receive sensory innervation from genitofemoral nerve. We proposed that addition of a genitof... |
2,331,886 | Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer. | Over the past decade, numerous nonviral cationic vectors have been synthesized. They share a high density of positive charges and efficiency for gene transfer in vitro. However, their positively charged surface causes instability in body fluids and cytotoxicity, thereby limiting their efficacy in vivo. Therefore, there... |
2,331,887 | Paroxysmal atrioventricular block in young patients.<Pagination><StartPage>506</StartPage><EndPage>512</EndPage><MedlinePgn>506-12</MedlinePgn></Pagination><Abstract><AbstractText>We describe 17 patients (8 girls, and 9 boys), aged 9.6 +/- 5.7 years, with paroxysmal atrioventricular block (PAVB), a condition rarely des... | We describe 17 patients (8 girls, and 9 boys), aged 9.6 +/- 5.7 years, with paroxysmal atrioventricular block (PAVB), a condition rarely described in children. Holter monitoring documented the PAVB in 15 patients, and tilt test was performed in 4 patients (positive in 1). The electrocardiograph (ECG) was normal in 7 pa... |
2,331,888 | Stability of cardiac waves. | Cardiac waves can fail to propagate when the membrane potential of the cells in the wavefront rises too slowly. The sodium channel inactivation gates play an important role in this process of propagation block. Simple models including inactivation gates can have travelling waves of constant form with two possible veloc... |
2,331,889 | Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture. | One of the overarching goals in developmental biology is the elucidation of mechanisms that elaborate form and function. To this end, an accurate morphological description of embryonic development is essential. However, visualizing dynamic changes in the three-dimensional (3D) structure of the developing embryo has bee... |
2,331,890 | [Lung transplantation in rats: a viable experimental model]. | To incorporate a new fast, safe, and reversible anesthetic procedure into the experimental model of lung transplantation (LT) using a cuff technique originally described by Mizuta.</AbstractText>Eighty-eight Sprague-Dawley rats were used in the experimental model. Thirty left LTs were performed, using 60 rats. The dono... |
2,331,891 | Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments. | Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single chain variable fragment with high affinity for its target epitope... |
2,331,892 | Effect of varying doses of fentanyl with low dose spinal bupivacaine for caesarean delivery in patients with pregnancy-induced hypertension. | The purpose of this study was to evaluate haemodynamic stability, perioperative analgesia and neonatal outcome following intrathecal 0.5% bupivacaine 7.5 mg with varying doses of fentanyl, in parturients with pregnancy-induced hypertension. Forty-five parturients with pregnancy-induced hypertension scheduled for caesar... |
2,331,893 | Effects of bilateral vestibular nucleus lesions on cardiovascular regulation in conscious cats. | The vestibular system participates in cardiovascular regulation during postural changes. In prior studies (Holmes MJ, Cotter LA, Arendt HE, Cas SP, and Yates BJ. Brain Res 938: 62-72, 2002, and Jian BJ, Cotter LA, Emanuel BA, Cass SP, and Yates BJ. J Appl Physiol 86: 1552-1560, 1999), transection of the vestibular nerv... |
2,331,894 | Anesthetic indices of sevoflurane and isoflurane in unpremedicated dogs. | <i>Prevalence of High Blood Pressure: </i> An estimated 1.8 million people in Sweden, or 27 percent of the adult population (aged 20 or older), have high blood pressure (hypertension). The condition is just as common among women as men. Of the 1.8 million Swedish adults with elevated blood pressure: 60 percent have mil... |
2,331,895 | [Accidental spinal metoclopramide injection: case report.]. | Accidental injection of non-spinal drugs in epidural and spinal spaces is a possible anesthetic complication. This report presents a case of inadvertent spinal metoclopramide injection.</AbstractText>Female patient, 17 years old, 69 kg, BMI = 26.2, physical status ASA I, 36 weeks and 4 days gestation, with acute fetal ... |
2,331,896 | PCA after subarachnoid block for cesarean section. | We studied the pain control, narcotic side effects, and PCA utilization with intravenous PCA morphine during 24 hours post cesarean section period. Fifty-two consecutive women were included in the study. Each received subarachnoid block with hyperbaric bupivacain with addition of fentanyl. After surgery, the patient re... |
2,331,897 | Aggressive cutaneous T-cell lymphomas after TNFalpha blockade. | Pharmacologic blockade of TNFalpha has been a highly effective approach to treating several immunologically mediated diseases, including rheumatoid arthritis, Crohn's disease, and psoriatic arthritis. 1,2,3 Both etanercept, the recombinant extracellular domain of the tumor necrosis factor receptor 2 (TNFR2), and inflix... |
2,331,898 | Centromere dynamics and chromosome evolution in marsupials. | The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwi... |
2,331,899 | The effect of remifentanil on cerebral blood flow velocity in children anesthetized with propofol. | Cerebrovascular stability and rapid anesthetic emergence are desirable features of a neuroanesthetic regimen. In this randomized crossover study the effect of a low-dose remifentanil infusion on cerebral blood flow velocity (CBFV) in children anesthetized with propofol was evaluated.</AbstractText>Twenty healthy childr... |
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