Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,331,600 | Evans index among adult Ghanaians on normal head computerized tomography scan. | Normal-Pressure Hydrocephalus (NPH) is a neurological condition which is made up of a clinical triad of gait disturbance, dementia and urinary incontinence and can be reversed by ventricular shunting. Currently, some guidelines suggest the use of Evans' index (EI) for diagnosis of hydrocephalus radiologically. Most of ... |
2,331,601 | Intraventricular dysembryoplastic neuroepithelial tumor in the temporal horn with Broad involvement of the ependyma. | Though typical dysembryoplastic neuroepithelial tumors (DNETs) are located in the cerebral cortex, an atypical DNET could occur in the temporal horn of the lateral ventricle and broadly involve the ependyma. Awareness of this atypical form of DNET is of value for the wright diagnosis and management of atypical DNETs. |
2,331,602 | Toward a phenomenology of congenital illness: a case of single-ventricle heart disease. | Phenomenology has contributed to healthcare by providing resources for understanding the lived experience of the patient and their situation. But within a burgeoning literature on the characteristic features of illness, there has not yet been an account appropriate to describe congenital illnesses: conditions which are... |
2,331,603 | Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and  review of the literature. | Choroid plexus carcinoma is an intraventricular neoplasm originating from the choroid plexus epithelium and is of rare occurrence in adults. However, owing to the low prevalence of choroid plexus carcinoma, there is very limited information about the disease entity and treatment. Here we report a rare case of choroid p... |
2,331,604 | Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood-brain barrier and neurovascular unit. | This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states impacting the brain barriers and brain fluids; drug delivery to the br... |
2,331,605 | Multi-channel bioimpedance spectroscopy based on orthogonal baseband shifting. | <i>Objective</i>. Multi-channel bioimpedance spectroscopy (BIS) systems typically sample each channel's impedance sequentially using multiplexers and a single analog-to-digital converter. These systems may lose their real-time capability with an increasing number of channels, especially for low excitation frequencies. ... |
2,331,606 | Nonoperative management of enlarging syringomyelia in clinically stable patients after decompression of Chiari malformation type I.<Pagination><StartPage>28</StartPage><EndPage>33</EndPage><MedlinePgn>28-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3171/2020.12.PEDS20621</ELocationID><Abstract>... | The authors aimed to describe the natural history and optimal management of persistent syringomyelia after suboccipital craniectomy for Chiari malformation type I (CM-I).</AbstractText>A cohort of all patients who presented to a tertiary pediatric hospital with newly diagnosed CM-I between 2009 and 2017 was identified.... |
2,331,607 | Biophysics-based statistical learning: Application to heart and brain interactions. | Initiatives such as the UK Biobank provide joint cardiac and brain imaging information for thousands of individuals, representing a unique opportunity to study the relationship between heart and brain. Most of research on large multimodal databases has been focusing on studying the associations among the available meas... |
2,331,608 | The role of imaging in the evaluation of hoarseness: A review. | Hoarseness is a common symptom indicating an abnormal change in the quality of voice and has a lifetime prevalence of around 30%. There are multiple causes of hoarseness, ranging from acute laryngitis, chronic laryngitis, laryngopharyngeal reflux, functional dysphonia due to vocal overuse or abuse, vocal cord paralysis... |
2,331,609 | Icarrin prevents cardiomyocyte apoptosis in spontaneously hypertensive rats by inhibiting endoplasmic reticulum stress pathways. | This study aimed to explore whether icarrin (ICA) can protect cardiomyocytes from hypertension-induced damage by inhibiting endoplasmic reticulum stress (ERS).</AbstractText>Spontaneously hypertensive rats (SHRs) were orally administered water or ICA at 10, 20 and 40 mg/kg once daily for 12 weeks, and Wistar-Kyoto (WKY... |
2,331,610 | Multiparametric Rest and Dobutamine Stress Magnetic Resonance in Assessment of Myocardial Viability. | MR feature-tracking (FT) is a novel technique that quantitatively calculates myocardial strain and can assess myocardial viability.</AbstractText>To evaluate the feasibility of FT at rest and with low-dose dobutamine (LDD), visual assessment of contractility with LDD and left ventricle (LV) end-diastolic wall thickness... |
2,331,611 | The rosette-forming glioneuronal tumor mimicked cerebral cysticercosis: a case report. | Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region. This is a comprehensive analysis of a 22-year-old woman with RGNT composed of mainly cystic components. In addition, the case showed multiple lesions located in brain paren... |
2,331,612 | Correlation between the levels of NLRP3, Hcy, IL-1β, IL-18 and the prognosis in patients with hemorrhagic stroke. | To explore the connection of nucleotide-binding oligomerization domain-like receptors 3 (NLRP3), homocysteine (Hcy), interleukin-1β (IL-1β), interleukin-18 (IL-18) in peripheral blood and prognosis in patients with hemorrhagic stroke.</AbstractText>A total of 84 patients with hemorrhagic stroke treated in o... |
2,331,613 | Integrated Clinical and Magnetic Resonance Imaging Assessments Late After Fontan Operation. | Several clinical and cardiac magnetic resonance (CMR)-derived parameters have been shown to be associated with death or heart transplant late after the Fontan operation.</AbstractText>The objective of this study was to identify the relative importance and interactions of clinical and CMR-based parameters for risk strat... |
2,331,614 | In utero fetal left ventricular rupture and pseudoaneurysm formation: a case report. | Cardiac ventricular aneurysms affect 1 in 200,000 live births. To the best of our knowledge, no reported cases of a left ventricular pseudoaneurym and in utero rupture exist to guide optimal management.</AbstractText>We present a case of fetal left ventricular rupture with a large pericardial effusion, cardiac tamponad... |
2,331,615 | Extracellular Vesicle TGF-β1 Is Linked to Cardiopulmonary Dysfunction in Human Immunodeficiency Virus. | Extracellular vesicles (EVs) have emerged as important mediators in cell-cell communication; however, their relevance in pulmonary hypertension (PH) secondary to human immunodeficiency virus (HIV) infection is yet to be explored. Considering that circulating monocytes are the source of the increased number of perivascu... |
2,331,616 | Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight. | Long-duration spaceflight induces structural changes in the brain and eye. Identification of an association between cerebral and ocular changes could help determine if there are common or independent causes and inform targeted prevention strategies or treatments.</AbstractText>To determine if there is an association be... |
2,331,617 | Is there myocardial involvement in children with long-term follow-up for Kawasaki disease? A study based on two-dimensional speckle tracking echocardiography. | This study aimed to determine the possibility of subclinical myocardial dysfunction detected by strain echocardiography in the late period of children with Kawasaki disease.</AbstractText>The study enrolled 30 patients with Kawasaki disease with a follow-up period of at least 12 months and 30 healthy age- and gender-ma... |
2,331,618 | Cerebrospinal Fluid Drop Metastases of Canine Glioma: Magnetic Resonance Imaging Classification. | Dissemination of glioma in humans can occur as leptomeningeal nodules, diffuse leptomeningeal lesions, or ependymal lesions. Cerebrospinal fluid (CSF) drop metastasis of glioma is not well-recognized in dogs. Ten dogs with at least two anatomically distinct and histologically confirmed foci of glioma were included in t... |
2,331,619 | Lateral ventricular medulloepithelioma in children: a case report. | Medulloepithelioma is an extremely rare highly malignant and rapidly growing tumor that occurs in the central nervous system. There are few reports of medulloepithelioma located in the ventricle. Medulloepithelioma is common in young children and adolescence. Herein, we described an unusual case of vomiting in a 4-year... |
2,331,620 | Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos. | This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice.</AbstractText>Thirty pregnant mice were randomly divided into five main study groups including the untreated control and 4 experi... |
2,331,621 | Benefits of Endoscopic Sheath in Intraventricular Neuroendoscopy: Technical Note. |  The usefulness of the endoscopic sheath is underreported in the literature.</AbstractText> To explain the use of an endoscopic sheath and to highlight its benefits.</AbstractText> In addition to protecting the surrounding brain parenchyma when inserting the endoscope, the endoscopic sheath is a ve... |
2,331,622 | The stress responsive gene ankrd1a is dynamically regulated during skeletal muscle development and upregulated following cardiac injury in border zone cardiomyocytes in adult zebrafish. | Ankyrin repeat domain 1 (ANKRD1) is a functionally pleiotropic protein found in the nuclei and sarcomeres of cardiac and skeletal muscles, with a proposed role in linking myofibrilar stress and transcriptional regulation. Rapid upregulation of its expression in response to both physiological and pathological stress sup... |
2,331,623 | Stereo-EEG Evaluation and Surgical Treatment in Patients With Drug-Resistant Focal Epilepsy Associated With Nodular Heterotopia. | Nodular heterotopia (NH) is a common cause of drug-resistant epilepsy. Only limited studies detail the treatment of NH with laser interstitial thermal therapy and none analyze the relation between epileptogenicity and NH location.</AbstractText>We retrospectively studied nine patients with drug-resistant epilepsy and N... |
2,331,624 | Pre-operative embolization for staged treatment of infantile choroid plexus papilloma. | Choroid plexus papillomas (CPPs) are benign but rare neuroepithelial neoplasms of the choroid plexus that represent the non-malignant form of a spectrum of tumors of the choroid plexus. The vast majority of CPPs present in children under 5 years of age. Some CPPs are diagnosed prenatally, but many of them reach a large... |
2,331,625 | Prognostic value of right ventricular dilatation in patients with COVID-19: a multicentre study. | Although cardiac involvement has prognostic significance in coronavirus disease 2019 (COVID-19) and is associated with severe forms, few studies have explored the prognostic role of transthoracic echocardiography (TTE). We investigated the link between TTE parameters and prognosis in COVID-19.</AbstractText>Consecutive... |
2,331,626 | Open-source 3D printable frameless stereotaxic system for young and adult pigs. | Here we present an open-source solution, comprising several 3D-printable mechanical pieces and software tools, for frameless stereotaxic targeting in young and adult pigs of varying weights.</AbstractText>Localization was achieved using an IR camera and CT imaging. The positions of the tools were followed, after regist... |
2,331,627 | Early second-trimester three-dimensional transvaginal neurosonography of fetal midbrain and hindbrain: normative data and technical aspects. | To provide a detailed description of the sonographic appearance and development of various fetal structures of the midbrain and hindbrain (MBHB) during the early second trimester, and to evaluate the impact of the frequency of the transvaginal sonography (TVS) transducer on the early recognition of these structures.</A... |
2,331,628 | Acute effect of thymoquinone on action potential and ionic currents of rat cardiac myocytes. | This study aims to investigate the acute effects of thymoquinone (TQ) which has been suggested to be a cardioprotective agent, on ventricular myocytes.</AbstractText>Freshly isolated rat ventricular myocytes were exposed to TQ and using standard whole-cell patch-clamp technique action potential (AP), sodium current (IN... |
2,331,629 | Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation. | Several psychiatric, neurologic and neurodegenerative disorders present increased brain ventricles volume, being hydrocephalus the disease with the major manifestation of ventriculomegaly caused by the accumulation of high amounts of cerebrospinal fluid (CSF). The molecules and pathomechanisms underlying cerebral ventr... |
2,331,630 | Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation. | Pathophysiological evidence from temporal lobe epilepsy models highlights the hippocampus as the most affected structure due to its high degree of neuroplasticity and control of the dynamics of limbic structures, which are necessary to encode information, conferring to it an intrinsic epileptogenicity. A loss in this c... |
2,331,631 | Comparison of IQOS (heated tobacco) and cigarette smoking on cardiac functions by two-dimensional speckle tracking echocardiography. | IQOS is a novel tobacco product claimed to be safer than conventional cigarette smoking due to the heat-not-burn system. This study aimed to evaluate the acute effects of IQOS smoking on myocardial systolic and diastolic functions and also compare the acute impacts of IQOS with cigarette smoking.</AbstractText>In this ... |
2,331,632 | Neurons and Astrocytes in Ventrolateral Periaqueductal Gray Contribute to Restraint Water Immersion Stress-Induced Gastric Mucosal Damage via the ERK1/2 Signaling Pathway. | The restraint water immersion stress (RWIS) model includes both psychological and physical stimulation, which may lead to gastrointestinal disorders and cause gastric mucosal damage. The ventrolateral periaqueductal gray (VLPAG) contributes to gastrointestinal function, but whether it is involved in RWIS-induced gastri... |
2,331,633 | Lower-body dynamic exercise reduces wave reflection in healthy young adults. | What is the central question of this study? There is a paradoxical reduction in augmentation index during lower-body dynamic (LBD) exercise in the face of an increase in central pressure. To determine causality, the amplitudes of forward and backward pressure waves were assessed separately using wave separation analysi... |
2,331,634 | Mutations in HID1 Cause Syndromic Infantile Encephalopathy and Hypopituitarism. | Precursors of peptide hormones undergo posttranslational modifications within the trans-Golgi network (TGN). Dysfunction of proteins involved at different steps of this process cause several complex syndromes affecting the central nervous system (CNS). We aimed to clarify the genetic cause in a group of patients charac... |
2,331,635 | Ependymal ciliary motion and their role in congenital hydrocephalus. | Since a case of hydrocephalus in humans considered to be caused by ciliary dysfunction was first reported by Greenstone et al. in 1984, numerous papers on the correlation between ciliary function and hydrocephalus have been published.</AbstractText>We reviewed the published literature on primary ciliary dyskinesia... |
2,331,636 | [Myocardial infarction in a patient with a single ventricle of the heart]. | A clinical case of myocardial infarction in a patient with single ventricle heart defect is described. |
2,331,637 | Endoscopic Assistance in the Deep and Narrow Spaces of the Brain-Microscopic Tumor Surgery Supported by the New Micro-Inspection Tool QEVO® (Technical Note). | <b>Introduction:</b> To evaluate the feasibility and efficacy of the innovative micro-inspection tool QEVO® (Carl Zeiss Meditec, Oberkochen, Germany) as an endoscopic adjunct to microscopes for better visualization of the surgical field in complex deep-seated intracranial tumors in infants and adults. <b>Materials... |
2,331,638 | Case Report: An Adult Patient With Deficiency of Adenosine Deaminase 2 Resembled Unilateral Frosted Branch Angiitis. | <b>Purpose:</b> Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive systemic autoinflammatory disorder. We describe a rare case of an adult patient with DADA2 who presented with unilateral frosted branch angiitis (FBA) combined with branch retinal vein occlusion and panuveitis. <b>Method:</b> This... |
2,331,639 | Case Report: Aicardi-Goutières Syndrome Caused by Novel TREX1 Variants. | TREX1 (three prime repair exonuclease 1) gene encodes DNA 3' end repair exonuclease that plays an important role in DNA repair. Mutations in TREX1 gene have been identified as the cause of a rare autoimmune neurological disease, Aicardi-Goutières syndrome (AGS). Here, we report an AGS case of a 6-month-old Chinese... |
2,331,640 | Enlarging Ventriculus Terminalis in a Patient With Polyarteritis Nodosa. | Ventriculus terminalis (VT) is a cystic embryological remnant within the conus medullaris that normally regresses after birth. In rare cases, it may persist into adulthood and give rise to neurologic symptoms. The pathogenesis remains unclear but is thought to be related to failed embryonic regression with other propos... |
2,331,641 | Isolated cerebral Rosai-Dorfman disease presenting as a sole mass protruding into the fourth ventricle: A case report. | Rosai-Dorfman disease is a non-Langherans cell histiocytosis typically revealed by a lymphadenopathy. Central nervous system involvement is rare, exceptionally isolated, and usually consists of dural masses mimicking meningioma. Very few reports have described non-dural-based lesions, especially with an intra-ventricul... |
2,331,642 | Nosological Differences in the Nature of Punctate White Matter Lesions in Preterm Infants. | <b>Background:</b> The pathogenesis of punctuate white matter lesions (PWMLs), a mild form of white matter damage observed in preterm infants, is still a matter of debate. Susceptibility-weighted imaging (SWI) allows to differentiate PWMLs based on the presence (SWI+) or absence (SWI-) of hemosiderin, but little is kno... |
2,331,643 | Cardiac Resynchronization Therapy Remote Monitoring - COVID-19 Pandemic Experiences and Future Perspectives. | Cardiac resynchronization therapy (CRT) is a well-established form of the treatment for heart failure (HF) in patients with left ventricle contraction dyssynchrony. Apart from typical in-office management, remote monitoring enables constant surveillance on both the patient's and the device's condition. This way, in cas... |
2,331,644 | Intraventricular haemorrhage and posthaemorrhagic ventricular dilatation: moving beyond CSF diversion. | Advances in medical care have led to more premature babies surviving the neonatal period. In these babies, germinal matrix haemorrhage (GMH), intraventricular haemorrhage (IVH) and posthaemorrhagic ventricular dilatation (PHVD) are the most important determinants of long-term cognitive and developmental outcomes. In th... |
2,331,645 | Renal denervation prevents myocardial structural remodeling and arrhythmogenicity in a chronic kidney disease rabbit model. | The electrophysiological (EP) effects and safety of renal artery denervation (RDN) in chronic kidney disease (CKD) are unclear.</AbstractText>The purpose of this study was to investigate the arrhythmogenicity of RDN in a rabbit model of CKD.</AbstractText>Eighteen New Zealand white rabbits were randomized to control (n... |
2,331,646 | Large lateral intraventricular tumors - Outcome of radical surgery. | This is a retrospective analysis of 145 cases of lateral intraventricular tumors that were larger than 4 cm in their maximum dimension. The aim of surgery was radical tumor resection. During the period January 2000 to December 2019, 145 cases of lateral intraventricular tumors were treated by surgery by an interhe... |
2,331,647 | The splenial angle: a novel radiological index for idiopathic normal pressure hydrocephalus. | To evaluate the utility of the splenial angle (SA), an axial angular index of lateral ventriculomegaly measured on diffusion tensor MRI color fractional anisotropy maps, in differentiating NPH from Alzheimer's disease (AD), Parkinson's disease (PD), and healthy controls (HC), and post-shunt changes in NPH, compared to ... |
2,331,648 | Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review. | In the twenty-first century, choroid plexus cauterization (CPC) in combination with endoscopic third ventriculostomy (ETV) has emerged as an effective treatment for some infants with hydrocephalus, leading to the favourable condition of 'shunt independence'. Herein we provide a narrative technical review considering th... |
2,331,649 | Intracardiac Echocardiography to Guide Catheter Ablation of Idiopathic Ventricular Arrythmias. | Catheter ablation is the most effective treatment option for idiopathic ventricular arrhythmias. Intracardiac echocardiography (ICE) has been increasingly used during ablation procedures, allowing real-time visualization of cardiac anatomy, and improving our understanding of the relationships between different cardiac ... |
2,331,650 | Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration. | Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the mechanisms underlying spinal cord regeneration. We previously found that tail amputation leads to reactivation of a developmental-like program in spinal cord ependymal cells (Rodrigo Albors et al., 2015), characterized by a high-p... |
2,331,651 | Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress. | The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly rela... |
2,331,652 | Cerebrospinal fluid and intraoperative squash cytology of childhood ependymoma. | Ependymomas are glial neoplasms of central nervous system originated from the ependymal lining of the brain ventricles and spinal cord central canal, and rarely exfoliated into cerebrospinal fluid (CSF). In this case we report the cytomorphological and immunocytomorphological features of ependymoma in CSF and intraoper... |
2,331,653 | Impact of Viral PCR Positive Nasal Swabs (Non Covid-19) on Outcomes Following Cardiac Surgery. | Viral bronchiolitis is a relative contraindication to elective pediatric cardiac surgery. Nasopharyngeal swab utilizing polymerase chain reaction (PCR) screening for viruses known to cause bronchiolitis are commonly available. The objective of this study was to evaluate clinical outcomes in patients with nasopharyngeal... |
2,331,654 | Incidental Discovery of a Presacral Extradural Myxopapillary Ependymoma. | Ependymoma is a malignant central nervous system tumor arising from the lining of the ventricles or central canal of the spinal cord. Extradural spinal ependymomas arise from heterotopic ependymal cells or the coccygeal medullary vestige and are extremely infrequent. We present a rare case of presacral extradural epend... |
2,331,655 | Methamphetamine Enhances HIV-Induced Aberrant Proliferation of Neural Progenitor Cells via the FOXO3-Mediated Mechanism. | Maintaining an intact pool of neural progenitor cells (NPCs) is crucial for generating new and functionally active neurons. Methamphetamine (METH) can exacerbate the HIV-induced deficit of adult neurogenesis; however, potential mechanisms of this influence are still poorly understood. In the present study, we present e... |
2,331,656 | Parametric-based feature selection via spherical harmonic coefficients for the left ventricle myocardial infarction screening. | Computer-aided diagnosis (CAD) of heart diseases using machine learning techniques has recently received much attention. In this study, we present a novel parametric-based feature selection method using the three-dimensional spherical harmonic (SHs) shape descriptors of the left ventricle (LV) for intelligent myocardia... |
2,331,657 | Severe hydrocephalus in a raccoon dog (Nyctereutes procyonoides). | Hydrocephalus is one of the most common central nervous system malformations in domestic dogs, yet they are poorly documented and studied in wild carnivoran mammals. A pup of raccoon dog (Nyctereutes procyonoides) was rescued and brought to Wildlife Center. The pup showed generalized ataxia, a domed skull, and an open ... |
2,331,658 | Contrast Enhancement of the Normal Infundibular Recess Using Heavily T2-weighted 3D FLAIR. | The purpose of the present study was to evaluate contrast enhancement of the infundibular recess in the normal state using heavily T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) (HT2-FLAIR).</AbstractText>Twenty-six patients were retrospectively recruited. We subjectively assessed overall contrast enhanceme... |
2,331,659 | Identification of the Facial Colliculus in Two-dimensional and Three-dimensional Images. | The facial colliculus (FC), an important landmark for planning a surgical approach to brainstem cavernous malformation (BCM), is a microstructure; therefore, it may be difficult to identify on magnetic resonance imaging (MRI). Three-dimensional (3D) images may improve the FC-identification certainty; hence, this study ... |
2,331,660 | Systemic vascular air embolus following CT-guided transthoracic needle biopsy: a potentially fatal complication. | Following an uncomplicated CT-guided transthoracic biopsy, a patient becomes unconscious and subsequently dies despite immediate cardiac resuscitation. The patient felt well during the procedure but started complaining about dizziness and chest pain when he sat up. When he again was put in a supine position, cardiac ar... |
2,331,661 | Right Ventricular Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis. | This systematic review and meta-analysis aimed to describe the features of right ventricular impairment and pulmonary hypertension in coronavirus disease (COVID-19) and assess their effect on mortality.</AbstractText>The authors carried out a systematic review and meta-analysis of observational studies.</AbstractText>T... |
2,331,662 | SARS-CoV-2 targets glial cells in human cortical organoids. | Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived brain organoids offer a valuable in vitro approach to study the... |
2,331,663 | The Outcomes of Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus: 317 Pediatric and Adult Cases. | To evaluate the role of endoscopic third ventriculostomy (ETV) as a primary or secondary treatment for hydrocephalus and factors affecting ETV success.</AbstractText>Pediatric and adult patients with symptomatic hydrocephalus treated with ETV during 11 years (2008?2019) in our clinic were retrospectively evaluated. Pat... |
2,331,664 | Scale-adaptive deep network for deformable image registration. | Multiresolution hierarchical strategy is typically used in conventional optimization-based image registration to capture varying magnitudes of deformations while avoiding undesirable local minima. A rough concept of the scale is captured in deep networks by the reception field of kernels, and it has been realized to be... |
2,331,665 | High resolution structural and functional MRI of the hippocampus in young adults with Down syndrome. | Down syndrome is the phenotypic consequence of trisomy 21, with clinical presentation including both neurodevelopmental and neurodegenerative components. Although the intellectual disability typically displayed by individuals with Down syndrome is generally global, it also involves disproportionate deficits in hippocam... |
2,331,666 | Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis. | Rett syndrome (RTT) is a rare neurodevelopmental disorder that results in multiple disabilities. Exosomal microRNA (miRs) from urine-derived stem cells (USCs) have been shown to induce neurogenesis and aid in functional recovery from brain ischemia. In the present study, we sought to determine whether that exosomal miR... |
2,331,667 | Perspectives on Endoscopic Transseptal Interforniceal Approach for Retroforaminal Colloid Cysts. | Although the interforniceal approach with the preservation of the fornix is useful during the endoscopic approach for retroforaminal colloid cysts, it carries a significant risk of memory and cognitive difficulties. Because most reports have reported the endoscopic approach to colloid cysts through the foramen with lit... |
2,331,668 | Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus. | Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in < 1% of patients with multiple myeloma. Many patients with LMM present with neurologic symptoms referable to cranial neuropathies, while the manifestation of communicating hydrocephalus has been underrecognized. A Japanese man with Bence... |
2,331,669 | Complications in AVM Surgery. | In AVM surgery perioperative complications can arise and can have serious perioperative consequences. Surgically related complications in AVM treatment, in many cases, can be avoided by paying attention to details:1. Careful selection of the patient: - addressing a patient with eloquent AVM to Gamma Knife treatm... |
2,331,670 | LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells. | Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRIG1 as an important regulator. We show that BMP-4 signaling induces a d... |
2,331,671 | Left ventricular twist predicts mortality in severe aortic stenosis.<Pagination><StartPage>225</StartPage><EndPage>232</EndPage><MedlinePgn>225-232</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/heartjnl-2020-318800</ELocationID><Abstract><AbstractText Label="OBJECTIVE">Left ventricular (LV) tw... | In AVM surgery perioperative complications can arise and can have serious perioperative consequences. Surgically related complications in AVM treatment, in many cases, can be avoided by paying attention to details: 1. Careful selection of the patient: - addressing a patient with eloquent AVM to Gamma Knife treat... |
2,331,672 | Nitric Oxide-cGMP Pathway Modulation in an Experimental Model of Hypoxic Pulmonary Hypertension. | Manipulation of nitric oxide (NO) may enable control of progression and treatment of pulmonary hypertension (PH). Several approaches may modulate the NO-cGMP pathway in vivo. Here, we investigate the effectiveness of 3 modulatory sites: (i) the amount of l-arginine; (ii) the size of plasma NO stores that stimulate solu... |
2,331,673 | TREM2 variants as a possible cause of frontotemporal dementia with distinct neuroimaging features. | Nasu-Hakola disease (NHD) is a rare, autosomal recessive disorder characterized by skeletal and neurological symptoms. Behavioral symptoms with cognitive impairment may mimic the behavioral variant of frontotemporal dementia (bvFTD) and other early-onset dementias. Our patients were analyzed and the literature was revi... |
2,331,674 | Insights into therapeutic targets and biomarkers using integrated multi-'omics' approaches for dilated and ischemic cardiomyopathies. | At present, heart failure (HF) treatment only targets the symptoms based on the left ventricle dysfunction severity; however, the lack of systemic 'omics' studies and available biological data to uncover the heterogeneous underlying mechanisms signifies the need to shift the analytical paradigm towards network-centric ... |
2,331,675 | The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats. | The protective effect of aspirin against myocardial hypertrophy (MH) was studied. Model rats of pressure overload MH were prepared by abdominal aortic coarctation. Rats were randomly divided into the sham group (<i>n</i> = 9), MH model group (<i>n</i> = 9), and MH+aspirin group (<i>n</i> = 9), which was, respectively, ... |
2,331,676 | Successful percutaneous treatment with the Konar MF™-VSD Occluder in an infant with Abernethy syndrome-case report. | Cyanosis persisting after surgical repair of complex congenital heart disease (CHD) may be related to the underlying disease. However, extracardiac causes should be also considered. We report on a patient with heterotaxy syndrome and double outlet right ventricle, in whom postoperative cyanosis was associated with an A... |
2,331,677 | Exosomes derived from human amniotic fluid mesenchymal stem cells alleviate cardiac fibrosis via enhancing angiogenesis <i>in vivo</i> and <i>in vitro</i>. | Cardiac fibrosis is a pathological process characterized by excess extracellular matrix (ECM) deposition and plays a critical role in nearly all types of heart disease. The mechanism of cardiac fibrosis is still unclear and no effective medication treatment of cardiac fibrosis. Research showed that mesenchymal stem cel... |
2,331,678 | ID4 Is Required for Normal Ependymal Cell Development. | Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription... |
2,331,679 | Failing Fontan. | Dr. O.P. Yadava, CEO & Chief Cardiac Surgeon, National Heart Institute, New Delhi, India, and Editor-in-Chief, <i>Indian Journal of Thoracic and Cardiovascular Surgery</i>, in conversation with Prof. Richard Jonas, Paediatric Cardiac Surgeon from Washington DC, USA, on Failing Fontan. |
2,331,680 | Cruveilhier's Unrecognized Case (c1831) of Dyke-Davidoff-Masson Syndrome. | In his serially published atlas of pathology, Anatomie Pathologique du Corps Humain (1829-1842), French anatomist and pathologist Jean Cruveilhier (1791-1874) provided an early clinical-pathologic description of Dyke-Davidoff-Masson syndrome. Cruveilhier's case was initially published around 1830, more than a century b... |
2,331,681 | Long-Term Outcomes of Patients with Hydrocephalus Secondary to Tectal Plate Glioma versus Idiopathic Aqueductal Stenosis: Results from a Single Center. | Tectal plate gliomas (TPG) constitute a distinct entity of benign tumors of the brain stem which show an indolent clinical course. Adequate treatment of secondary hydrocephalus is undoubtedly a major factor in the outcome. However, little is known about to what degree the tumor itself determines the long-term outcome o... |
2,331,682 | Catheter-based interventions versus medical and surgical approaches in acute pulmonary embolism.<Pagination><StartPage>1382</StartPage><EndPage>1390</EndPage><MedlinePgn>1382-1390</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jvsv.2021.02.015</ELocationID><ELocationID EIdType="pii" ValidYN="... | Objective - to determine the features of the daily profile of blood pressure (BP), blood lipid spectrum, features of left ventricular remodeling in patients with hypertension in combination with RA and to evaluate the effectiveness of using medium doses of rosuvastatin to correct dyslipidemia in this group of patients.... |
2,331,683 | Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disorders. | The diverse number of neurons in the cerebral cortex are generated during development by neural stem cells lining the ventricle, and they continue maturing postnatally. Dynamic chromatin regulation in these neural stem cells is a fundamental determinant of the emerging property of the functional neural network, and the... |
2,331,684 | Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse. | The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic structures controlling complex behaviors. OTX2 is also produced in choroid plexus epithelium, from which it is secreted into cerebrospinal fluid and transferred to limbic structure... |
2,331,685 | Longitudinal MRI brain volume changes over one year in children with mucopolysaccharidosis types IIIA and IIIB. | To quantify changes in segmented brain volumes over 12 months in children with mucopolysaccharidosis types IIIA and IIIB (MPS IIIA and IIIB).</AbstractText>In order to establish suitable outcome measures for clinical trials, twenty-five children greater than 2 years of age were enrolled in a prospective natural history... |
2,331,686 | Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice. | Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its long-term effects have not been completel... |
2,331,687 | Endothelial dysfunction in obstructive sleep apnea patients. | Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular diseases. The aim of the study was to assess the influence of OSAS on endothelial dysfunction and thrombosis biomarkers and to evaluate the effect of treatment with continuous positive airway pressure (CPAP) on biomarker levels.</A... |
2,331,688 | Tension pneumoventricle: Reversible cause for aphasia. | Pneumocephalus is air in the cranium commonly seen in postcraniotomy and in head injury patients. When this air causes an increase in intracranial pressure leading to neurological deterioration, it is called tension pneumocephalus. Similarly, intraventricular air causing compression on vital centers and increasing intr... |
2,331,689 | Comprehensive genetic analysis confers high diagnostic yield in 16 Japanese patients with corpus callosum anomalies. | Corpus callosum anomalies (CCA) is a common congenital brain anomaly with various etiologies. Although one of the most important etiologies is genetic factors, the genetic background of CCA is heterogenous and diverse types of variants are likely to be causative. In this study, we analyzed 16 Japanese patients with cor... |
2,331,690 | A 3D personalized cardiac myocyte aggregate orientation model using MRI data-driven low-rank basis functions. | Cardiac myocyte aggregate orientation has a strong impact on cardiac electrophysiology and mechanics. Studying the link between structural characteristics, strain, and stresses over the cardiac cycle and cardiac function requires a full volumetric representation of the microstructure. In this work, we exploit the struc... |
2,331,691 | Echocardiographic Indicators Associated with Adverse Clinical Course and Cardiac Sequelae in Multisystem Inflammatory Syndrome in Children with Coronavirus Disease 2019. | Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 causes significant cardiovascular involvement, which can be a determinant of clinical course and outcome. The aim of this study was to investigate whether echocardiographic measures of ventricular function were independently ... |
2,331,692 | Neuroanatomical organization of methionine-enkephalinergic system in the brain of the Mozambique tilapia Oreochromis mossambicus. | Enkephalins are a class of opioid peptides implicated in several physiological and neuroendocrine responses in vertebrates. In this study, using immunocytochemical or immunofluorescence technique, we examined the neuroanatomical distribution of methionine enkephalin (M-ENK) immunoreactivity in the central nervous syste... |
2,331,693 | Endogenous µ-opioid receptor activity in the lateral and capsular subdivisions of the right central nucleus of the amygdala prevents chronic postoperative pain. | Tissue injury induces a long-lasting latent sensitization (LS) of spinal nociceptive signaling that is kept in remission by an opposing µ-opioid receptor (MOR) constitutive activity. To test the hypothesis that supraspinal sites become engaged, we induced hindpaw inflammation, waited 3 weeks for mechanical hy... |
2,331,694 | Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy. | Takotsubo cardiomyopathy (TCM) is characterized by transient left ventricle dysfunction.</AbstractText>A residual cardiac and endothelial dysfunction is present in patients who recovered from TCM.</AbstractText>In this single-center prospective study, patients with prior TCM were included and followed for 6.4 ... |
2,331,695 | Ultrahigh density atrio-ventricular dual-chamber mapping as a next generation tool for ablation of accessory pathways. | Detailed three-dimensional (3D) mapping has been useful for effective radiofrequency catheter ablation. The Rhythmia system can create atrio-ventricular dual-chamber mapping, which reveals the atrial and ventricular potentials all at once in the same map. The aim of this study was to investigate the utility of mapping ... |
2,331,696 | PSMB4 inhibits cardiomyocyte apoptosis via activating NF-κB signaling pathway during myocardial ischemia/reperfusion injury. | Myocardial ischemia/reperfusion (I/R) injury induces cardiomyocyte apoptosis to deteriorate heart function. Thus, how to inhibit cardiomyocyte apoptosis is the focus of recent researches. Proteasome family member PSMB4 (proteasome subunit beta type-4) promotes cell survival. The relationship between PSMB4 and cardiomyo... |
2,331,697 | Native contrast visualization and tissue characterization of myocardial radiofrequency ablation and acetic acid chemoablation lesions at 0.55 T. | Low-field (0.55 T) high-performance cardiovascular magnetic resonance (CMR) is an attractive platform for CMR-guided intervention as device heating is reduced around 7.5-fold compared to 1.5 T. This work determines the feasibility of visualizing cardiac radiofrequency (RF) ablation lesions at low field CMR an... |
2,331,698 | Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations. | The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy (1</sup> H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, La... |
2,331,699 | Intracranial Cerebrospinal Fluid Volume Evaluation in Healthy People and Hydrocephalus Patients using SPACE Sequence. | Cerebrospinal Fluid (CSF) is produced mainly by the choroid plexus but with a substantial influence by the ependymal lining of the ventricles in the brain. Hydrocephalus occurs as a result of discrepancy in the production as well as circulation of CSF as a result of congenital and acquired conditions. Nevertheless, stu... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.