Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,333,300 | [Investigation of properties of the thermostable protein complex obtained from the myocardium left ventricles of adult white rats]. | A thermostable protein complex (TSPC) obtained from the myocardium ventricules of adult rats inhibits mitotic and transcriptional activity of cardiomyocytes. At the same time this complex is more active on early stages of the postnatal ontogenesis in rats, aged 1 and 5 days. Following its action on RNA synthesis, the T... |
2,333,301 | Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. | KCNQ1 (Kv7.1 or KvLQT1) encodes the alpha-subunit of a voltage-gated potassium channel found in tissues including heart, brain, epithelia and smooth muscle. Tissue-specific characteristics of KCNQ1 current are diverse, due to modification by ancillary subunits. In heart, KCNQ1 associates with KCNE1 (MinK), producing a ... |
2,333,302 | Long-term and immediate effect of testosterone on single T-type calcium channel in neonatal rat cardiomyocytes. | In the cardiovascular system, T-type calcium channels play an important role for the intracellular calcium homeostasis and spontaneous pacemaker activity and are involved in the progression of structural heart diseases. Androgens influence the cardiovascular physiology and pathophysiology. However, their effect on nati... |
2,333,303 | Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. | Ropivacaine 1% 40 ml was mistakenly injected as part of an axillary plexus block in an 84-year-old woman. After 15 min the patient complained of dizziness and drowsiness and developed a generalised tonic-clonic seizure followed by an asystolic cardiac arrest. After 10 min of unsuccessful cardiopulmonary resuscitation, ... |
2,333,304 | The effect of peribulbar block with ropivacaine on bi-hemispheric cerebral oxygen saturation in aged patients. | We evaluated the effects of peribulbar block for eye surgery on bi-hemispheric regional cerebral oxygenation (rSO2)) of aged patients. In 66 adult patients, peribulbar block was performed using ropivacaine 10 mg.ml(-1) with hyaluronidase 100 IU.ml(-1). Cerebral oxygenation was monitored using continuous non-invasive, n... |
2,333,305 | Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. | Activation of circulating platelets by exposed vessel wall collagen is a primary step in the pathogenesis of heart attack and stroke, and drugs to block platelet activation have successfully reduced cardiovascular morbidity and mortality. In humans and mice, collagen activation of platelets is mediated by glycoprotein ... |
2,333,306 | Cell adhesion molecules for targeted drug delivery. | Rapid advancement of the understanding of the structure and function of cell adhesion molecules (i.e., integrins, cadherins) has impacted the design and development of drugs (i.e., peptide, proteins) with the potential to treat cancer and heart and autoimmune diseases. For example, RGD peptides/peptidomimetics have bee... |
2,333,307 | Contributions of GABAergic and glutamatergic mechanisms to isoflurane-induced suppression of thalamic somatosensory information transfer. | Indications for a pivotal role of the thalamocortical network in producing the state of anesthesia have come from in vivo animal studies as well as imaging studies in humans. We studied possible synaptic mechanisms of anesthesia-induced suppression of touch perception in the rat's thalamus. Thalamocortical relay neuron... |
2,333,308 | [Effect of serum autoantibodies against the M2 muscarinic acetylcholine receptors from patients with heart failure on L-Type Ca2+ channel activity in guinea pig cardiac myocytes]. | To investigate the effect of serum autoantibodies against the human M(2) muscarinic acetylcholine receptors (M(2)-receptors, Abs) from patients with congestive heart failure on L-Type Ca(2+) channel activity in guinea pig cardiac myocytes.</AbstractText>Using whole cell patch-clamp technique, we quantitatively measured... |
2,333,309 | [Tolerance of Huso dauricus embryo at its different development stages to low temperature]. | This paper studied the embryo hatching rate and larva survival rate of Huso dauricus when the embryo at its different development stages was exposed to low temperature for different durations. The results showed that the embryo at its yolk plug, narrow-opening, and neural block closing stages could not survive at 2 - 8... |
2,333,310 | Sensitization following LVAD implantation using leucodepleted blood is not due to HLA antibodies. | Implantation of left ventricular assist devices (LVAD) is associated with HLA antibody sensitization. The objective of this study was to determine the specificity of antibodies produced by LVAD recipients using a combination of ELISA, Luminex and microcytotoxicity assays. Fifty-one LVAD patients were studied, from 44 t... |
2,333,311 | Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. | Bone marrow-derived endothelial progenitor cells (EPCs) have the ability to migrate to ischemic organs. However, the signals that mediate trafficking and recruitment of these cells are not well understood. Using a functional genomics strategy, we determined the genes that were upregulated in the ischemic myocardium and... |
2,333,312 | Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. | Cardiac remodeling following myocardial infarction (MI) is a maladaptive process, fundamental to the progression of ischemic heart failure. The extent of remodeling is influenced by mechanical stress, inflammatory response and activation of matrix metalloproteinases (MMPs). This study examined regional association betw... |
2,333,313 | A surprising case of sustained antenatal fetal bradycardia. | Persistent fetal bradycardia noted in the antenatal period can occur secondary to maternal conditions, fetal cardiac structural defects, or from congenital heart block. Fetal bradycardia can be mistaken for maternal pulse and should be confirmed with ultrasound whenever possible. Prompt evaluation of the fetus with bra... |
2,333,314 | A comparison of effects of alfentanil, fentanyl, and remifentanil on hemodynamic and respiratory parameters during stereotactic brain biopsy. | The aim of this study was to compare the effects of 3 different sedative-analgesic regimens in patients with intracranial mass lesions undergoing stereotactic brain biopsy. A 135 outpatients with American Society of Anesthesiologists I to II were divided into 3 groups: group A (n = 45) received a loading dose of IV alf... |
2,333,315 | Ultrasonography-guided rectus sheath block in paediatric anaesthesia--a new approach to an old technique. | The purpose of this study was an anatomical and clinical evaluation of ultrasonography-guided rectus sheath blocks in children.</AbstractText>A total of 30 children were included in the sono-anatomical part of the study. The depth of the anterior and posterior rectus sheath was evaluated with a portable SonSite 180 plu... |
2,333,316 | [Cardiac manifestations during viral acute hepatitis]. | The authors describe a retrospective study conducted on 46 patients with acute viral hepatitis, searching for cardiac disorders. These disorders appeared in about 43% of cases, only with benign evolution. The most frequent alterations are electrocardiographic disorders, followed by conduction blocks, axis deviations an... |
2,333,317 | Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioning. | Ischemic preconditioning fails to confer immediate cardioprotection in the absence of testosterone, indicating that the hormone is required for the process. Here we set out to determine whether testosterone is also necessary for delayed cardioprotection and, if so, how it acts. Male Sprague Dawley rats (7-8 wk) underwe... |
2,333,318 | Modeling the calcium gate of cardiac gap junction channel. | We addressed the question how Ca2+ transients affect gap junction conductance (Gj) during action potential (AP) propagation by constructing a dynamic gap junction model coupled with a cardiac cell model. The kinetics of the Ca2+ gate was determined based on published experimental findings that the Hill coefficient for ... |
2,333,319 | Atypical MRI findings in Kearns-Sayre syndrome: T2 radial stripes. | Kearns-Sayre syndrome (KSS) is a mitochondrial disorder consisting of external ophthalmoplegia, retinitis pigmentosa, ataxia and heart block. Magnetic resonance imaging (MRI) shows abnormal T2 high signal intensity in the deep gray matter nuclei, the cerebellar and the subcortical white matter. We report an unusual MR ... |
2,333,320 | Evaluation of blood pressure changes using vascular transit time. | Imbalance of the human haemodynamic system can provide a prognosis of syncope, dizziness or hypertension. This can be assessed by monitoring its responses to postural change. Examining variations in blood pressure (BP) is deemed an effective means to identify symptoms of this associated condition. However, conventional... |
2,333,321 | Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. | We have proposed that activation of cerebral perivascular sympathetic alpha7-nicotinic acetylcholine receptors (alpha7-nAChRs) by nicotinic agonists releases norepinephrine, which then acts on parasympathetic nitrergic nerves, resulting in release of nitric oxide and vasodilation. Using patch-clamp electrophysiology, i... |
2,333,322 | Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. | Matrix metalloproteinases (MMPs) contribute to left ventricular remodeling after myocardial infarction (MI). Specific causative roles of particular MMPs, however, remain unclear. MMP-7 is abundant in cardiomyocytes and macrophages, but MMP-7 function after MI has not been defined.</AbstractText>Wild-type (WT; n=55) and... |
2,333,323 | Endothelin-1 and PKC induce positive inotropy without affecting pHi in ventricular myocytes. | It has been proposed that intracellular alkalinization underlies the enhanced contractility of ventricular myocytes exposed to endothelin (ET)-1. The effects of ET-1 on the contractility and intracellular pH (pH(i)) were examined here in cultured adult rat ventricular myocytes by employing the pH-sensitive fluorescent ... |
2,333,324 | Addition of cisatracurium to lidocaine for intravenous regional anesthesia. | To determine the onset and regression time of motor and sensory block, and the quality of anesthesia and postoperative analgesia by the addition of cisatracurium to local anesthetic solution in small doses in intravenous regional anesthesia.</AbstractText>Prospective, randomized, double-blind study.</AbstractText>Unive... |
2,333,325 | An evaluation of a polyamine-deficient diet for the treatment of inflammatory pain. | Polyamines are thought to be involved in the regulation of numerous metabolic and electrophysiological processes in the nervous system. In this study we evaluated the effect of a synthetic polyamine-deficient diet on pain in a carrageenan (Car)-induced inflammatory rat model. Inflammation was induced with a unilateral ... |
2,333,326 | Pulse transit time based on piezoelectric technique at the radial artery. | Pulse transit time (PTT) has shown its potential in relevant cardiovascular and cardiorespiratory studies. However, the use of photoplethysmography (PPG) in PTT measurement can be limited in events of poor peripheral perfusion. Uninterrupted PTT monitoring may also not be achievable when less cooperative patients distr... |
2,333,327 | Analgesic efficacy of two doses of intrathecal midazolam with bupivacaine in patients undergoing cesarean delivery. | In this prospective, randomized, double-blind, placebo-controlled study, we investigated the postoperative analgesic efficacy of 2 doses of intrathecal midazolam as an adjunct to bupivacaine for spinal anesthesia.</AbstractText>Sixty patients undergoing elective cesarean delivery under spinal anesthesia were allocated ... |
2,333,328 | Direct observation of protein folding in nanoenvironments using a molecular ruler. | We observe folding of horse heart cytochrome c in various environments including nano-compartments (micelles and reverse micelles). Using picosecond-resolved Förster resonance energy transfer (FRET) dynamics of an extrinsic covalently attached probe dansyl (donor) at the surface of the protein to a heme group (acc... |
2,333,329 | Modification of cutaneous vasodilator response to heat stress by daytime exogenous melatonin administration. | In humans, the nocturnal fall in internal temperature is associated with increased endogenous melatonin and with a shift in the thermoregulatory control of skin blood flow (SkBF), suggesting a role for melatonin in the control of SkBF. The purpose of this study was to test whether daytime exogenous melatonin would shif... |
2,333,330 | Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily alpha3beta2 and/or alpha6betaX to alpha3beta4. | Nicotinic receptors play an essential role in central cardiorespiratory function, however, the types of nicotinic receptors responsible for activating cardiac vagal neurons in the nucleus ambiguus that control heart rate are unknown. This study tests whether alpha-conotoxin MII and alpha-conotoxin AuIB sensitive nicoti... |
2,333,331 | Superoxide radical production by allopurinol and xanthine oxidase. | Oxypurinol, an inhibitor of xanthine oxidase (XO), is being studied to block XO-catalyzed superoxide radical formation and thereby treat and protect failing heart tissue. Allopurinol, a prodrug that is converted to oxypurinol by xanthine oxidase, is also being studied for similar purposes. Because allopurinol, itself, ... |
2,333,332 | Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits. | To determine the effects of meloxicam and butorphanol on minimum alveolar concentration of isoflurane (MAC(ISO)) in rabbits.</AbstractText>10 healthy young adult female rabbits.</AbstractText>Rabbits were anesthetized with isoflurane on 3 occasions in a blinded, randomized complete block design to determine the MAC(ISO... |
2,333,333 | L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. | Cardiac voltage-gated L-type Ca channels (Ca(V)) are multiprotein complexes, including accessory subunits such as Ca(V)beta2 that increase current expression. Recently, members of the Rad and Gem/Kir-related family of small GTPases have been shown to decrease current, although the mechanism remains poorly defined. In t... |
2,333,334 | Micropatterns of propagation. | Alterations in microscopic conduction could contribute to microreentry and arrhythmogenesis in pathological settings. This chapter reviews microconduction in the ventricular myocardium. Gap junctions play a significant role in longitudinal and transverse propagation of the action potential wavefront in the ventricle. S... |
2,333,335 | Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. | Ischemia and reperfusion (I/R) injury is associated with extensive loss of cardiac myocytes. Bnip3 is a mitochondrial pro-apoptotic Bcl-2 protein which is expressed in the adult myocardium. To investigate if Bnip3 plays a role in I/R injury, we generated a TAT-fusion protein encoding the carboxyl terminal transmembrane... |
2,333,336 | Safety of amiodarone in the prevention of postoperative atrial fibrillation: a meta-analysis. | A meta-analysis was conducted to assess the safety of amiodarone in the prevention of postoperative atrial fibrillation.</AbstractText>A search of the medical literature was conducted to identify randomized controlled trials of prophylactic amiodarone use in cardiothoracic surgery. Studies were independently reviewed b... |
2,333,337 | The voltage dependence of recovery from use-dependent block by QX-222 separates mechanisms for drug egress in the cardiac sodium channel. | In neuronal sodium channels of squid giant axons, recovery from QX-222 block is slowed by hyperpolarization. However, in ventricular cells, hyperpolarization speeds recovery. Previously, we showed that isoform-specific residues in the external side of the cardiac sodium channel isoform (D1P-loop C373 and D4S6 T1752) in... |
2,333,338 | Increased AAI mode pacing threshold after termination of atrial fibrillation by acute administration of disopyramide phosphate. | We studied changes in atrial pacing threshold after termination of atrial fibrillation (AF) by acute administration of disopyramide phosphate (DP) to elucidate the suitable setting for atrial pacing output before AF termination.</AbstractText>Four patients with sick sinus syndrome implanted with AAI mode pacemakers wer... |
2,333,339 | Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome). | Autoimmune diseases (AD) occur frequently in women during their childbearing years and may influence pregnancy outcome and neonatal health. Patients with systemic lupus erythematosus (SLE) can experience a disease flare-up during pregnancy with potential negative effects on the product of conceptus, especially if the d... |
2,333,340 | Recombinant P-selectin glycoprotein-ligand-1 delays thrombin-induced platelet aggregation: a new role for P-selectin in early aggregation. | 1. P-selectin is involved, with P-selectin glycoprotein (GP)-ligand-1 (PSGL-1), in platelet/leukocyte interactions during thrombo-inflammatory reactions; it also stabilizes platelet aggregates. Its antagonism accelerates thrombolysis and enhances the anti-aggregatory effects of GPIIb-IIIa inhibitors. This study was des... |
2,333,341 | Unrecognized drug-drug interactions: a cause of intraoperative cardiac arrest? | Many physicians overlook, or are unaware of, most drug-drug interactions. In our patient, the local anesthetic used for an axillary block may have been the precipitating drug in a cascade of drug-drug interactions that resulted in a cardiac arrest. The combination of multiple preoperative drug-drug interactions prevent... |
2,333,342 | Subarachnoid butorphanol augments lidocaine sensory anaesthesia in calves. | To determine the efficacy and safety of subarachnoid butorphanol combined with lidocaine, six calves were studied. Each calf underwent two treatments, at least one week apart, via subarachnoid injection: (1) butorphanol (0.03 mg/kg) plus 2% lidocaine (4 mg/kg) and (2) 2% lidocaine (4 mg/kg) alone. Subarachnoid injectio... |
2,333,343 | Metalloprotein-dependent decomposition of S-nitrosothiols: studies on the stabilization and measurement of S-nitrosothiols in tissues. | The stabilization of S-nitrosothiols is critical for the development of assays to measure their concentration in tissues. Low-molecular-weight S-nitrosothiols are unstable in tissue homogenates, even in the presence of thiol blockers or metal-ion chelators. The aim of this study was to try and stabilize low-molecular-w... |
2,333,344 | Sitaxsentan: an endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. | Endothelin (ET-1) is a potent vasoconstrictor and smooth muscle mitogen that mediates its effects through activation of ET-A and ET-B receptors. Pulmonary arterial hypertension (PAH) encompasses a heterogeneous group of disorders characterised by inappropriate overactivation of the ET system. There is clear evidence th... |
2,333,345 | Transplanted neonatal cardiomyocytes as a potential biological pacemaker in pigs with complete atrioventricular block. | Sinus node dysfunction and severe heart block are major indications for electronic pacemaker implantation. The aim of the present study was to investigate the feasibility of an alternative approach by using spontaneously excitable cell grafts to serve as a biological pacemaker.</AbstractText>Enzymatically isolated neon... |
2,333,346 | Use of bovine somatotropin for increased skeletal and lean tissue growth of Holstein steers. | One hundred-sixty Holstein growing-finishing steers (initial BW of 185 kg) were blocked by BW to determine the effectiveness of long-term bovine somatotropin (bST) administration on lean, skeletal, and carcass measurements. Steers were randomly allocated to 4 treatments (10 steers/treatment) within a block (n = 4 block... |
2,333,347 | The safety of digoxin as a pharmacological treatment of atrial fibrillation.<Pagination><StartPage>453</StartPage><EndPage>467</EndPage><MedlinePgn>453-67</MedlinePgn></Pagination><Abstract><AbstractText>Digoxin has traditionally been the drug of choice for ventricular rate control in patients with chronic atrial fibri... | Digoxin has traditionally been the drug of choice for ventricular rate control in patients with chronic atrial fibrillation (AF), with or without heart failure (HF) with systolic dysfunction. In patients with permanent AF, digoxin monotherapy is ineffective to control ventricular rate during exercise, but the combinati... |
2,333,348 | [COX-2 mediates U50488H-induced delayed cardioprotection in isolated rat heart]. | To determine whether U50488H, a selective agonist of kappa-opioid receptor, could induce biphasic (early and late) cardioprotection against myocardial ischemia/reperfusion injury and to explore the underlying mechanisms.</AbstractText>Isolated perfused rat hearts were subjected to 30 min of ischemia followed by 120 min... |
2,333,349 | Prolongation of the cardiac QTc interval in Turner syndrome. | Anatomic anomalies of the cardiovascular system occur in approximately 50% of individuals with Turner syndrome (TS), with the specific genetic cause(s) for the heart defects still unknown. Because congenital heart disease may be associated with conduction system abnormalities, we compared electrocardiograms (ECGs) in 1... |
2,333,350 | The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue. | Electrical heterogeneities play a role in the initiation of cardiac arrhythmias. In certain pathological conditions such as ischaemia, current sinks can develop in the diseased cardiac tissue. In this study, we investigate the effects of changing the amount of heterogeneity and intercellular coupling on wavefront stabi... |
2,333,351 | NAC and DTT promote TGF-beta1 monomer formation: demonstration of competitive binding. | TGF-Beta plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-beta and found that freshly isolated peripheral blood monocytes spontaneously released TGF-beta. Stimulating these monocytes with GM-CSF or LPS, but n... |
2,333,352 | Conduction system disease in fetuses evaluated for irregular cardiac rhythm. | To determine the prevalence of 1st and 2nd degree AV block in fetuses with an irregular cardiac rhythm, and to summarize outcome of these pregnancies.</AbstractText>The diagnosis of irregular cardiac rhythm or 'skipped beats' includes isolated ectopy that resolves spontaneously. Recently, Doppler measurements of the 'm... |
2,333,353 | "Sensing alternans" in a patient with a newly implanted pacemaker. | This report describes the case of an 80-year-old man with a history of coronary artery disease who presented with acute pericarditis secondary to pacemaker lead perforation of the ventricular wall 2 days after undergoing dual lead pacemaker implantation. The electrocardiogram revealed sinus rhythm with an intra-atrial ... |
2,333,354 | Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. | Thyroid hormone (TH) is critical for cardiac development and heart function. In heart disease, TH metabolism is abnormal, and many biochemical and functional alterations mirror hypothyroidism. Although TH therapy has been advocated for treating heart disease, a clear benefit of TH has yet to be established, possibly be... |
2,333,355 | Recurrent congenital heart block in neonatal lupus. | Congenital heart block (CHB) is the main complication of neonatal lupus (NL) and is strongly associated with the presence of anti-SSA/Ro and anti-SSB/La antibodies. The recurrence of CHB in subsequent pregnancies in mothers with these antibodies is uncommon, occurring in approximately 15% of cases. We describe here a c... |
2,333,356 | [Dorsal medulla oblongata stroke after a wasp sting]. | Although wasp stings can cause local reactions such as pain, flare, edema, swelling and severe reactions, including anaphylaxis; neurological vascular complications are rare.</AbstractText>We report a case of a 36-year-old male who developed focal neurological symptoms after a wasp sting. The brain MRI showed an infarc... |
2,333,357 | Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. | Partial T cell depletion is used in solid organ transplantation as a valuable strategy of peritransplant induction immunosuppression. Using a murine cardiac allograft model, we recently demonstrated that this led to lymphopenia-induced (homeostatic) proliferation among the residual nondepleted lymphocytes. Rather than ... |
2,333,358 | [Obstetrical management of patients at risk of neonatal lupus syndrome: review of the literature]. | Fetuses and infants of women with anti-SSA/Ro and anti-SSB/La antibodies are at risk of neonatal lupus syndrome, featuring skin lesions, hematological and hepatic disorders, and congenital heart block (CHB) in the absence of severe cardiac malformation. The prevalence of CHB in newborns of anti-SSA/Ro positive women wi... |
2,333,359 | Adenosine test in the diagnosis of unexplained syncope: marker of conducting tissue disease or neurally mediated syncope? | Adenosine test (supine administration of a 20 mg intravenous bolus with electrocardiographic and blood pressure monitoring) has been endorsed by the European Society of Cardiology guidelines on syncope management as an 'experimental' test in the diagnosis of unexplained syncope. The test is quick and cheap, but there i... |
2,333,360 | Heart rate variability-guided prophylactic treatment of severe hypotension after subarachnoid block for elective cesarean delivery. | Baseline low-to-high frequency ratio (LF/HF) of heart rate variability predicted hypotension after subarachnoid block (SAB). LF/HF-guided treatment of hypotension with vasopressors or colloids was investigated.</AbstractText>In 80 women scheduled to undergo cesarean delivery during SAB, LF/HF and systolic blood pressur... |
2,333,361 | Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. | Alpha(2A)-adrenergic receptors (alpha(2A)AR) regulate multiple central nervous system, cardiovascular, and metabolic processes including neurotransmitter release, platelet aggregation, blood pressure, insulin secretion, and lipolysis. Complex diseases associated with alpha(2A)AR dysfunction display familial clustering,... |
2,333,362 | Reversible vagal blockade in conscious rats using a targeted delivery device. | Reversible methods of nerve blockade greatly aid neurophysiological and behavioral studies. We have developed an implantable device for the local delivery of anesthetics to the area surrounding the vagal nerve in rats. The device consists of a thick silicone tube for insulating the nerves from the surrounding tissue, a... |
2,333,363 | hERG potassium channels and cardiac arrhythmia. | hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs.... |
2,333,364 | Clonidine addition prolongs the duration of caudal analgesia. | In this study, using a dose-ranging design, we examined the effects of clonidine with 0.125% bupivacaine on the duration of post-operative analgesia in caudal anaesthesia in children.</AbstractText>We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children, aged 1-10 years, undergoin... |
2,333,365 | Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. | This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to interact with vascular alpha1-adrenoceptors in the pithed rat. These ligands included: methiothepin, methysergide and metergoline (5-HT(1)/5-HT2); WAY-100635, busp... |
2,333,366 | Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog. | Cardiogenic shock is the leading cause of death among patients hospitalized with acute myocardial infarction (MI). Understanding the mechanisms for acute pump failure is therefore important. The aim of this study is to examine in an acute MI dog model whether mitochondrial bio-energetic function within non-ischemic wal... |
2,333,367 | Detection method to minimize variability in photoplethysmographic signals for timing-related measurement. | Photoplethysmography (PPG) is a common optical technique used to monitor peripheral pulsation. Studies have shown that minimal variability in phase characteristics is critical to attain accurate estimation of timing-related measurements, such as heart rate and pulse transit time. Observed abrupt changes from baseline o... |
2,333,368 | Time course of cardiovascular neural regulation during programmed 20-sec apnea in rats. | Long-term hypoxia results in hemodynamic breakdown in patients in the intensive care unit; however, intermittent hypoxia causes hypertension in individuals with sleep apnea. The objective of this study was to explore the sequential cardiovascular neural alterations in response to acute hypoxic apnea.</AbstractText>The ... |
2,333,369 | Quaternary derivatives of granatanol diesters: potent, ultrashort acting non-depolarizing neuromuscular relaxants. | The purpose of this study was to explore the feasibility of utilizing the granatanol: N-methyl [9-azabicyclo (3.3.1) nonane] 3-alpha-ol as the terminal group in a series of new bisquaternary azabicycyclic diester-type neuromuscular blocking agents. Fifty two bisquaternary ammonium derivatives of several dicarboxylic ac... |
2,333,370 | Relationship between adiponectin, glycemic control and blood lipids in diabetic type 2 postmenopausal women with and without complication of ischemic heart disease. | Recently major adipocytokine, adiponectin, are thought to play important roles in the regulation of cardiovascular and metabolic homeostasis. We compared serum adiponectin concentrations and lipid profile in diabetic patients with and without complication of cardiovascular disease in postmenopausal women.</AbstractText... |
2,333,371 | Life-threatening bradyarrhythmia after massive azithromycin overdose. | 9-month-old infant was inadvertently administered azithromycin 50 mg/kg, taken from floor stock, instead of the prescribed ceftriaxone. Shortly thereafter, she became unresponsive and pulseless. The initial heart rhythm observed when cardiopulmonary resuscitation was started was a widecomplex bradycardia, with a prolon... |
2,333,372 | Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study. | Individuals with type 2 diabetes are at increased risk of cardiovascular disease (CVD) mortality and display increased levels of subclinical CVD. Genetic variation in PTPN1, a diabetes susceptibility gene, was investigated for a role in diabetic atherosclerosis. The PTPN1 gene encodes protein tyrosine phosphatase-1B, w... |
2,333,373 | Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high-dose dexamethasone in utero. | Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring.</AbstractText>To assess neuropsychological development in babies ex... |
2,333,374 | Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block. | A long QT mutation in the cardiac sodium channel, D1790G (DG), shows enhanced flecainide use-dependent block (UDB). The relative importance of open and inactivated states of the channel in flecainide UDB has been controversial. We used a modifiable, inactivation-deficient mutant channel that contains the F1486C mutatio... |
2,333,375 | Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section. | To compare the effect of adding fentanyl to intrathecal bupivacaine on the onset, duration and quality of spinal anesthesia and its effect of mother and neonate.</AbstractText>Single blind randomized controlled clinical trial.</AbstractText>Department of Anesthesiology, Surgical Intensive Care Unit and Pain Management,... |
2,333,376 | Trypanosoma cruzi infection and nuclear factor kappa B activation prevent apoptosis in cardiac cells.<Pagination><StartPage>1580</StartPage><EndPage>1587</EndPage><MedlinePgn>1580-7</MedlinePgn></Pagination><Abstract><AbstractText>Studies of cardiac pathology and heart failure have implicated cardiomyocyte apoptosis as... | Studies of cardiac pathology and heart failure have implicated cardiomyocyte apoptosis as a critical determinant of disease. Recent evidence indicates that the intracellular protozoan parasite Trypanosoma cruzi, which causes heart disease in chronically infected individuals, impinges on host apoptotic pathways in a cel... |
2,333,377 | A randomised comparison of 0.5% bupivacaine with a lidocaine/epinephrine/fentanyl mixture for epidural top-up for emergency caesarean section after "low dose" epidural for labour. | When extending a fentanyl-containing, low-dose labour epidural for emergency caesarean section it has been shown that there is no difference in time to surgical readiness between plain bupivacaine 0.5% and mixtures of lidocaine/epinephrine or lidocaine/bupivacaine/epinephrine. However, it is not known whether adding fe... |
2,333,378 | A computer-aided ECG diagnostic tool. | Jordan lacks companies that provide local medical facilities with products that are of help in daily performed medical procedures. Because of this, the country imports most of these expensive products. Consequently, a local interest in producing such products has emerged and resulted in serious research efforts in this... |
2,333,379 | Role of capsaicin-sensitive sensory nerves in mediation of the cardiovascular effects of the essential oil of croton zehntneri leaves in anaesthetized rats. | The essential oil of Croton zehntneri Pax et Hoffm. (EOCZ) contains anethole (42%) and estragole (46%), two isomers that share some chemical structural similarities with capsaicin. The present study investigated the cardiovascular effects of EOCZ and the role of capsaicin-sensitive sensory nerve fibres in the mediation... |
2,333,380 | No apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytes. | The majority of Na channels in the heart are composed of the tetrodotoxin (TTX)-resistant (KD, 2 to 6 micromol/L) "cardiac" NaV1.5 isoform; however, TTX-sensitive (KD, 1 to 25 nmol/L) "neuronal" Na channel isoforms have recently been detected in several cardiac preparations. In the present study, we determined the func... |
2,333,381 | Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits. | cGMP and opening of mitochondrial K(ATP) channel play an important role in preconditioning of the heart following ischemia/reperfusion (I/R) injury. We investigated the cardioprotective effect of vardenafil (VAR) (Levitra), a highly selective and biochemically potent inhibitor of phosphodiesterase-5 (PDE-5) that enhanc... |
2,333,382 | Association of socioeconomic status with functional capacity, heart rate recovery, and all-cause mortality. | Lower socioeconomic status (SES) confers heightened cardiovascular risk and mortality, although the mediating pathways are unclear.</AbstractText>To evaluate the extent to which exercise physiologic characteristics account for the association between lower SES and mortality.</AbstractText><AbstractText Label="DESIGN, S... |
2,333,383 | Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. | Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about 90% induced by rocuronium or the non-steroi... |
2,333,384 | Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart. | The aim of the present study was to determine whether the clinically effective cardioprotection conferred by puerarin (Pue) against ischemia and reperfusion is mediated by mitochondrial transmembrane pores and/or channels. Hearts isolated from male Sprague-Dawley rats were perfused on a Langendorff apparatus and subjec... |
2,333,385 | Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors. | P2X receptors, activated by extracellular ATP, may be important in regulating cardiac function. The objective of the present study was to characterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whether they are involved in mediating the effect of extracellular ATP. Membrane cu... |
2,333,386 | Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes. | To study the impact of injection of verapamil and adenosine in the coronary arteries on TIMI (Thrombolysis in Myocardial Infarction) frame count (TFC) after percutaneous coronary intervention (PCI) in patients with an acute coronary syndrome (ACS).</AbstractText>Prospective, randomised, controlled study of the intracor... |
2,333,387 | [Adenosine reduces intracellular free calcium concentration in guinea pig ventricular myocytes]. | To observe the effects of adenosine on intracellular calcium concentration ([Ca2+]i) level in guinea pig ventricular myocytes and to define the possible mechanisms involved.</AbstractText>The effects of adenosine on [Ca2+]i were investigated in guinea pig ventricular myocytes. [Ca2+]i was detected by laser confocal mic... |
2,333,388 | [Intravenous dexmedetomidine for sedation does not interfere with sensory and motor block duration during spinal anesthesia.]. | The association among local and regional anesthesia is a very useful and common practice. However, some patients may become anxious and require sedation. Benzodiazepines, opioids and propofol are widely used for this aim. Alpha2-adrenergic agonists have hypnotic and sedative properties and represent an alternative to p... |
2,333,389 | Spontaneous pulmonary interstitial emphysema in a term unventilated infant. | Pulmonary interstitial emphysema (PIE) is a form of air block most frequently seen in ventilated preterm infants with severe lung disease; it is rarely reported in spontaneously breathing term infants. We report on an infant previously diagnosed with laryngomalacia and congestive heart failure and with evidence of ante... |
2,333,390 | Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy. | Mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel plays a key role in cardioprotection. Hence, a sulfonylurea that does not block mitoK(ATP) channels would be desirable to avoid damage to the heart. Accordingly, we examined the effects of sulfonylureas on the mitoK(ATP) channel and mitochondrial Ca(2+) overload.</A... |
2,333,391 | Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase. | Organophosphorus esters (OP) are highly toxic chemicals used as pesticides and nerve agents. Their acute toxicity is attributed to inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) in nerve synapses. Our goal was to find a new therapeutic for protection against OP toxicity. We used a gene therapy vector, adeno-asso... |
2,333,392 | Is a dual-sensor pacemaker appropriate in patients with sino-atrial disease? Results from the DUSISLOG study. | Rate-responsive pacemakers (PMs) are often supplied with accelerometer (XL) and minute ventilation (MV) sensors to provide a physiologic rate response according to patient needs. No information is available about the real benefit of dual-sensor rate-responsive pacing on the daily life of patients.</AbstractText>DUSISLO... |
2,333,393 | Associations of childhood and adulthood height and the components of height with insulin-like growth factor levels in adulthood: a 65-year follow-up of the Boyd Orr cohort. | Taller individuals with longer legs have a higher risk of cancer but a lower risk of coronary heart disease.</AbstractText>We investigated whether childhood height and its components are associated with the IGF system in adulthood.</AbstractText>We analyzed data from 429 participants of the Boyd Orr cohort, for whom he... |
2,333,394 | Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. | The purpose of this study was to compare the onset and duration of sensory and motor block, as well as the hemodynamic changes and level of sedation, following intrathecal bupivacaine supplemented with either dexmedetomidine or clonidine.</AbstractText>In a prospective, double-blind study, 60 patients undergoing transu... |
2,333,395 | Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteries. | Synthetic peptides homologous to the extracellular loops of the major vascular connexins represent a novel class of gap junction blockers that have been used to assess the role of direct cellular communication in arteries and veins. However, the specificity of action of such peptides on the coupling between smooth musc... |
2,333,396 | TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. | Acute coronary syndromes (ACS) are precipitated by a rupture of the atherosclerotic plaque, often at the site of T cell and macrophage infiltration. Here, we show that plaque-infiltrating CD4 T cells effectively kill vascular smooth muscle cells (VSMC). VSMCs sensitive to T cell-mediated killing express the death recep... |
2,333,397 | KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. | Rapidly activating Kv4 voltage-gated ion channels are found in heart, brain, and diverse other tissues including colon and uterus. Kv4.3 can co-assemble with KChIP ancillary subunits, which modify kinetic behavior. We examined the affinity and use dependence of nifedipine block on Kv4.3 and its modulation by KChIP2b. N... |
2,333,398 | Subarachnoid anesthesia for loco-regional antiblastic perfusion with circulatory block (stop-flow perfusion). | Loco-regional antiblastic perfusion with circulatory block (stop-flow perfusion, SFP) is a procedure designed to treat solid tumors of the limb and pelvis in an advanced stage, like melanoma, sarcoma of the soft tissues and colon-rectal cancer. The aim of this study was to evaluate if subarachnoid anesthesia could repr... |
2,333,399 | RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. | Neuropeptide FF (NPFF) has been proposed to play a role in pain modulation, opioid tolerance, and several other physiological processes. However, pharmacological agents that would help define physiological roles for this peptide are still missing. Here we report the discovery of a potent and selective NPFF receptor ant... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.