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2,333,100 | Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels. | Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF). In the present study, we performed association study of single nucleotide polymorphisms (SNPs) surrounding the natriuretic peptide precursor B (NPPB) gene with plasma BNP levels in 2970 adult... |
2,333,101 | Riluzole and D-amphetamine interactions in humans. | In preclinical studies, medications which decrease glutamate release have been shown to block some of the effects of psychostimulants. One such medication is riluzole, marketed for the treatment of Amyotrophic Lateral Sclerosis (ALS). The goal of this study was to determine riluzole's effects on acute physiological and... |
2,333,102 | Vasopressin dysregulation and hyponatremia in hospitalized patients. | Hyponatremia, which is often due to dysregulation of arginine vasopressin, occurs frequently in hospitalized patients and is associated with increased morbidity and mortality. Nonosmotic secretion of arginine vasopressin is central to the pathophysiology of hyponatremia in patients with euvolemic hyponatremia (due to, ... |
2,333,103 | Effect of muscle relaxants on heart rate, arterial pressure, intubation conditions and onset of neuromuscular block in patients undergoing valve surgery. | Sixty six patients undergoing elective valve surgery were randomized to receive rocuronium bromide 0.6 mg/Kg (Group R, n=22), pancuronium bromide 0.1 mg/Kg (Group P, n= 22) and vecuronium bromide 0.1 mg/Kg (Group V, n=22), Measurements of heart rate and arterial pressure (systolic, diastolic and mean) were noted at the... |
2,333,104 | Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressure. | Systolic blood pressure is determined in large part by genes. Six independent studies have reported evidence of linkage between systolic pressure and chromosome 16p12 that incorporates SCNN1G, the gene encoding the gamma-subunit of the epithelial sodium channel. We undertook the first comprehensive association analysis... |
2,333,105 | Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. | The aim of this study was to determine whether cocaine's sympathomimetic actions can be reversed by a potent centrally acting alpha2 adrenergic receptor (AR) agonist (dexmedetomidine).</AbstractText>We recently showed that cocaine stimulates the human cardiovascular system primarily by acting in the brain to increase s... |
2,333,106 | Nitric oxide donor isosorbide mononitrate for pre-induction cervical ripening at 41 weeks' gestation: A randomized controlled trial. | Nitric oxide donors have been shown to cause cervical ripening. The aim of this study was to determine whether sustained release isosorbide mononitrate (ISMN-SR) 60 mg administered vaginally is effective for pre induction cervical ripening at 41 weeks' gestation.</AbstractText>A double-blind randomised controlled trial... |
2,333,107 | Spinal anesthesia for endoscopic urological surgery--low dose vs. varying doses of hyperbaric bupivacaine. | The aim of this study is to compare the efficiency of low dose vs. varying doses of hyperbaric bupivacaine in spinal anesthesia for endoscopic urological procedures.</AbstractText>Sixty consecutive patients were studied in a randomized prospective manner. They received either of 5 (Gr I), 7.5 (Gr II) or 10 mg (Gr III) ... |
2,333,108 | A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. | Mesenchymal stem cells (MSCs) display immunomodulatory properties mediated by various factors, including inducible nitric oxide synthase (iNOS). Since heme oxygenase-1 (HO-1) is a potent immunosuppressive enzyme, we tested the hypothesis that HO-1 could mediate the immunosuppressive effects of MSCs. We generated adult ... |
2,333,109 | Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. | The use of regional anaesthesia in thyroid surgery remains controversial. This double-blind, randomized controlled study was conducted to evaluate the analgesic efficacy of bilateral superficial cervical plexus block (BSCPB) performed under general anaesthesia in patients undergoing total thyroidectomy.</AbstractText>E... |
2,333,110 | A computational approach to predict pulse transit time variations during postural change. | The human autonomic nervous system modulates blood pressure (BP) and heart rate in order to maintain homeostasis. Present techniques that monitor BP may cause discomforts to children. Pulse transit time change (DeltaPTT) is known to be inversely correlated to BP change. In this study, a mathematical model using only a ... |
2,333,111 | An update on the management of Chagas cardiomyopathy. | Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, infects nearly 18 million people in Latin America and mainly affects the heart, causing heart failure, arrhythmias, heart block, thromboembolism, stroke and death. In this review, the clinical diagnosis and management of Chagas cardiomyopathy are discu... |
2,333,112 | Comparison of midazolam, propofol and fentanyl combinations for sedation and hemodynamic parameters in cataract extraction. | Midazolam, propofol and fentanyl were compared in terms of sedation during cataract extraction. Hemodynamic parameters, sedation level, postoperative satisfaction, and side effects were investigated.</AbstractText>The study was carried out in Hacettepe University Hospitals Ophthalmology Operating Theatres in 2005. The ... |
2,333,113 | Metabolic forearm vasodilation is enhanced following Bier block with phentolamine. | The extent to which sympathetic nerve activity restrains metabolic vasodilation in skeletal muscle remains unclear. We determined forearm blood flow (FBF; ultrasound/Doppler) and vascular conductance (FVC) responses to 10 min of ischemia [reactive hyperemic blood flow (RHBF)] and 10 min of systemic hypoxia (inspired O(... |
2,333,114 | Vasopressin-receptor antagonist therapy in patients with hyponatraemia. | Hyponatraemia often complicates the treatment of underlying conditions in patients who are seriously ill. Arginine vasopressin receptor antagonists block the action of arginine vasopressin and correct sodium and water imbalance in patients with euvolaemic or hypervolaemic hyponatraemia. |
2,333,115 | Oestrogen directly inhibits the cardiovascular L-type Ca2+ channel Cav1.2. | Oestrogen can modify the contractile function of vascular smooth muscle and cardiomyocytes. The negative inotropic actions of oestrogen on the heart and coronary vasculature appear to be mediated by L-type Ca(2+) channel (Ca(v)1.2) inhibition, but the underlying mechanisms remain elusive. We tested the hypothesis that ... |
2,333,116 | The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. | Na(+)/Ca(2+) exchangers (NCXs) and members of the canonical transient receptor potential (TRPC) channels play an important role in Ca(2+) homeostasis in heart and brain. With respect to their overlapping expression and their role as physiological Ca(2+) influx pathways a functional discrimination of both mechanisms see... |
2,333,117 | Cardiovascular influence of dental anxiety during local anesthesia for tooth extraction. | The present study evaluated whether dental patient anxiety has an effect on the cardiovascular response to the delivery of anesthetic to achieve mandibular anesthesia.</AbstractText>One hundred eighty adult patients scheduled to receive routine dental extraction under local anesthesia were enrolled in this prospective ... |
2,333,118 | Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts. | We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacton... |
2,333,119 | Neurological outcome in isolated congenital heart block and hydrops fetalis. | Isolated fetal heart block (HB), a condition associated with fetal hydrops, carries a high mortality rate and may result in neurodevelopmental sequelae. To the best of our knowledge, no data exist regarding the long-term outcome of such hydropic fetuses. We reviewed our experience with this condition to determine the n... |
2,333,120 | Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. | Biological pacemaking has been performed with viral vectors, human embryonic stem cells, and adult human mesenchymal stem cells (hMSCs) as delivery systems. Only with human embryonic stem cells are data available regarding stability for >2 to 3 weeks, and here, immunosuppression has been used to facilitate survival ... |
2,333,121 | Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes. | Shensong Yangxin (SSYX) is one of the compound recipe of Chinese materia medica. This study was conducted to investigate the effects of SSYX on sodium current (I(Na)), L-type calcium current (I(Ca, L)), transient outward potassium current (I(to)), delayed rectifier current (I(K)), and inward rectifier potassium current... |
2,333,122 | Pinto bean consumption reduces biomarkers for heart disease risk. | To determine effects of daily intake of 1/2 cup pinto beans, black-eyed peas or carrots (placebo) on risk factors for coronary heart disease (CHD) and diabetes mellitus (DM) in free-living, mildly insulin resistant adults over an 8 week period.</AbstractText>Randomized, crossover 3x3 block design. Sixteen participants ... |
2,333,123 | The role of p53 in nitric oxide-induced cardiomyocyte cell death. | The role of p53 in mediating nitric oxide (NO)-induced cell death remains uncertain. The exogenous NO donor S-nitrosoglutathione (GSNO) produced a concentration-dependent reduction in cell viability in embryonic chick cardiomyocytes in culture. Western blotting and immunocytochemistry for p53 showed that p53 was increa... |
2,333,124 | Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K(+) channel. | Regulation of ion channel activity plays a central role in controlling heart rate, rhythm, and contractility responses to cardiovascular demands. Dynamic beat-to-beat regulation of ion channels is precisely adjusted by autonomic stimulation of cardiac G protein-coupled receptors. The rapidly activating delayed rectifie... |
2,333,125 | The clinical application of metabolic therapy for cardiovascular disease. | Metabolic therapy involves the administration of a substance normally found in the body to enhance a metabolic reaction within the cell. This may be achieved in two ways. Firstly, for some systems a substance can be given to achieve greater than normal levels in the body so as to drive an enzymic reaction in a preferre... |
2,333,126 | Association of P-wave duration, dispersion, and terminal force in relation to P-wave axis among outpatients. | While P-wave duration (P-dur) and dispersion (P-disp) could both reflect fractionated and inhomogeneous propagation of sinus cardiac impulses, and may therefore be associated with each other, a clear relationship has not been extensively studied. We studied these markers as well as the significance of P-wave terminal f... |
2,333,127 | Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis. | Mechanical traumatic injury causes cardiomyocyte apoptosis and cardiac dysfunction. However, the signaling mechanisms leading to posttraumatic cardiomyocyte apoptosis remains unclear. The present study attempted to identify the molecular mechanisms responsible for cardiomyocyte apoptosis induced by trauma. Normal cardi... |
2,333,128 | [Urgent analgesia in a trauma patient]. | An 84-year-old patient with a fracture of the humerus suffered from severe pain. Analgesia was not sufficient using opioids. Because of a chronic heart disease a blockade of the brachial plexus was used for analgesia without any technical examination. The necessity of different medical examinations before block perform... |
2,333,129 | The role of the cyclooxygenase products in evoking sympathetic activation in exercise. | Animal studies suggest that prostaglandins in skeletal muscles stimulate afferents and contribute to the exercise pressor reflex. However, human data regarding a role for prostaglandins in this reflex are varied, in part because of systemic effects of pharmacological agents used to block prostaglandin synthesis. We hyp... |
2,333,130 | Small dose spinal bupivacaine for Cesarean delivery does not reduce hypotension but accelerates motor recovery. | Maternal hypotension occurs in 60-94% of Cesarean deliveries with 10-15 mg spinal bupivacaine. Reduced doses of bupivacaine may decrease the incidence of hypotension, nausea, and vasopressor use. The primary objective of this study was to compare 4.5 mg and 12 mg doses of intrathecal bupivacaine on maternal hemodynamic... |
2,333,131 | Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart.<Pagination><StartPage>1</StartPage><EndPage>9</EndPage><MedlinePgn>1-9</MedlinePgn></Pagination><Abstract><AbstractText>In this study, we investigated whether morphine dependence was inhibi... | In this study, we investigated whether morphine dependence was inhibited by phosphodiesterase (PDE) 4 inhibitors rolipram and diazepam, since a role for the cyclic AMP systems in the development of morphine dependence was reported. Dependence of morphine was induced by a 7-day s.c. implantation of morphine pellets. Mor... |
2,333,132 | Evaluation of anaesthesia methods in caesarean section for foetal distress. | The purpose of this study was to evaluate the anaesthetic technique for Caesarean section which was appropriate for the clinical situation. This retrospective study was conducted on 240 patients undergoing Caesarean section with indications of foetal distress during a 3-year period (2002-2004). The data were reviewed f... |
2,333,133 | A transcription-dependent mechanism, akin to that in adipose tissue, modulates lipoprotein lipase activity in rat heart. | The enzyme lipoprotein lipase (LPL) releases fatty acids from lipoprotein triglycerides for use in cell metabolism. LPL activity is rapidly modulated in a tissue-specific manner. Recent studies have shown that in rat adipose tissue this occurs by a shift of extracellular LPL toward an inactive form catalyzed by an LPL-... |
2,333,134 | Simulations of propagated mouse ventricular action potentials: effects of molecular heterogeneity. | The molecular heterogeneity of repolarizing currents produces significant spatial heterogeneity and/or dispersion of repolarization in many mammalian cardiac tissues. Transgenic mice are prominent experimental models for the study of the molecular basis of repolarization and arrhythmias. However, it is debated whether ... |
2,333,135 | Isoform-selective effects of isoflurane on voltage-gated Na+ channels. | Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isoforms expresse... |
2,333,136 | Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. | The interleukin-2 receptor alpha chain (IL-2Ra, CD25) plays a major part in shaping the dynamics of T cell populations following immune activation, due to its role in T cell proliferation and survival. Strategies to blunt the effector responses in transplantation have been developed by devising pharmaceutical agents to... |
2,333,137 | Role of topical calcineurin inhibitors on atopic dermatitis of children. | Besides the traditional topical treatment of mild and moderate forms of atopic dermatitis (AD), which includes the daily use of emollients and the intermittent use of topical corticosteroids (TCSs) as anti-inflammatory drugs, a new group of drugs has recently been introduced to control the inflammatory phase of the dis... |
2,333,138 | Temporal variability of repolarization in rat ventricular myocytes paced with time-varying frequencies. | Adaptation of action potential duration (APD) to pacing cycle length (CL) has been previously characterized in isolated cardiomyocytes for sudden changes in constant CL and for pre-/postmature stimuli following constant pacing trains. However, random fluctuations characterize both physiological sinus rhythm (up to 10% ... |
2,333,139 | Haemodynamic effects of intrathecal bupivacaine for surgical repair of hip fracture. | To determine the optimal dose of bupivacaine in providing adequate surgical anaesthesia with minimal haemodynamic disturbances.</AbstractText>Three different doses of spinal bupivacaine in combination with or without fentanyl for surgical repair of hip fracture were used. Sixty patients were randomly divided into three... |
2,333,140 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. | In the adult organism, it is well established that hypoxia followed by reperfusion may be fatal and result in generation of reactive oxygen species (ROS) and subsequent tissue damage. There is also considerable evidence that temporary decrease or interruption in oxygen supply to the embryo and ROS generation during rep... |
2,333,141 | Sub-plasmalemmal [Ca2+]i upstroke in myocytes of the guinea-pig small intestine evoked by muscarinic stimulation: IP3R-mediated Ca2+ release induced by voltage-gated Ca2+ entry. | Membrane depolarization triggers Ca(2+) release from the sarcoplasmic reticulum (SR) in skeletal muscles via direct interaction between the voltage-gated L-type Ca(2+) channels (the dihydropyridine receptors; VGCCs) and ryanodine receptors (RyRs), while in cardiac muscles Ca(2+) entry through VGCCs triggers RyR-mediate... |
2,333,142 | Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy. | Emery-Dreifuss muscular dystrophy (EDMD) is an inherited disorder characterized by slowly progressive skeletal muscle weakness in a humero-peroneal distribution, early contractures and prominent cardiomyopathy with conduction block. Mutations in EMD, encoding emerin, and LMNA, encoding A-type lamins, respectively, caus... |
2,333,143 | Elevated Ca2+ ATPase (SERCA2) activity in tuna hearts: comparative aspects of temperature dependence. | Tunas have an extraordinary physiology including elevated metabolic rates and high cardiac performance. In some species, retention of metabolic heat warms the slow oxidative swimming muscles and visceral tissues. In all tunas, the heart functions at ambient temperature. Enhanced rates of calcium transport in tuna myocy... |
2,333,144 | The vicissitudes of the pacemaker current I (Kdd) of cardiac purkinje fibers. | The mechanisms underlying the pacemaker current in cardiac tissues is not agreed upon. The pacemaker potential in Purkinje fibers has been attributed to the decay of the potassium current I (Kdd). An alternative proposal is that the hyperpolarization-activated current I (f) underlies the pacemaker potential in all card... |
2,333,145 | Sevoflurane increases fade of neuromuscular response to TOF stimulation following rocuronium administration in children. A PK/PD analysis. | Sevoflurane enhances neuromuscular block produced by rocuronium, affecting not only single twitch response but also the response to high-frequency stimulation, increasing tetanic [or train-of-four (TOF)] fade.</AbstractText>We compared the degree of fade during spontaneous recovery from rocuronium-induced neuromuscular... |
2,333,146 | Effects of oral cocaine on intravenous cocaine discrimination in humans. | This study was designed to evaluate the drug discrimination paradigm as a model for assessing the ability of potential agonist medications to block the effects of intravenous cocaine. Previous research has demonstrated that oral cocaine attenuated the subjective and physiological effects of intravenous cocaine injectio... |
2,333,147 | The guestbook of the urology department of Semmelweis University in Budapest: a mirror of international contacts. | The Department of Urology at Semmelweis University, Budapest was established in 1920 as one of the first independent urological clinics in Europe. The history of the guestbook begins in 1922 with Professor Illyés, the first appointed head of the department.</AbstractText>Information was collected on the most famou... |
2,333,148 | Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages. | Many of the healthcare consequences of cigarette smoking could be due to its ability to compromise the immune system, and in respiratory diseases like chronic obstructive pulmonary disease (COPD), a constant low level of infection could be responsible for some of the symptoms/pathology. The aim was to assess the impact... |
2,333,149 | Thrombin formation in vitro in response to shear-induced activation of platelets. | Thromboembolic events caused by implanted vascular devices present serious medical challenges. In particular bileaflet mechanical heart valves (MHVs) are prone to thrombus formation in the hinge region due to a combination of high shear stress and stagnation regions. Most studies of shear-induced platelet activation an... |
2,333,150 | Electronic dental anaesthesia for third inferior molar surgery. | The aim of this study was to evaluate the efficacy of Electronic Dental Anaesthesia (EDA) for third molar surgery.</AbstractText>Third molar extraction under regional anaesthesia (inferior alveolar and buccal nerve blocks) was performed in 2 groups of 30 patients each: group 1 = controls, group 2 = EDA treatment. Anxie... |
2,333,151 | Eponymous doctors associated with Edinburgh, Part 2--David Bruce, John Cheyne, William Stokes, Alexander Monro Secundus, Joseph Gamgee. | This, the second in a three-paper series with this title, looks at famous doctors who trained in Edinburgh and their eponyms. With one possible exception, none seems to have sought the eponym, nor awarded it to themselves, nor used it for self-promotion. Unlike those in the first paper, all eponyms in this paper are st... |
2,333,152 | Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice. | The purpose of these studies was to learn whether one isoform of nonmuscle myosin II, specifically nonmuscle myosin II-A, could functionally replace a second one, nonmuscle myosin II-B, in mice. To accomplish this, we used homologous recombination to ablate nonmuscle myosin heavy chain (NMHC) II-B by inserting cDNA enc... |
2,333,153 | Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. | Expression of the inflammatory chemokine, growth-related oncogene protein-alpha (GRO-alpha), from airway smooth muscle cells (ASMC) is regulated by pathways involving NF-kappaB and MAPK activation. We determined the effects of dexamethasone on GRO-alpha induced by IL-1beta or TNF-alpha with respect to the role of MAPK ... |
2,333,154 | [Levobupivacaine for parturients undergoing elective caesarean delivery. A dose-finding investigation]. | The optimum intrathecal dose of hyperbaric levobupivacaine for spinal anaesthesia during elective caesarean section has not yet been investigated.</AbstractText>A total of 30 parturients undergoing elective caesarean section were included in this prospective, randomised, double-blind study. Parturients received either ... |
2,333,155 | The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome. | Many drugs are known to block cardiac potassium channels, thus prolonging QT interval and predisposing to malignant arrhythmias. Patients with congenital long QT syndrome are particularly vulnerable, but usually electrophysiological effects of drugs have not been assessed in these patients at risk.</AbstractText>Fiftee... |
2,333,156 | Effects of pulsatile blood flow in large vessels on thermal dose distribution during thermal therapy. | The aim of this study is to evaluate the effect of pulsatile blood flow in thermally significant blood vessels on the thermal lesion region during thermal therapy of tumor. A sinusoidally pulsatile velocity profile for blood flow was employed to simulate the cyclic effect of the heart beat on the blood flow. The evolut... |
2,333,157 | Predictors of rehabilitation outcomes: a comparison of Israeli and Italian geriatric post-acute care (PAC) facilities using the minimum data set (MDS). | To understand the relative contribution of sociodemographic, clinical, and health care features to rehabilitation outcomes in Israel and in Italy in post-acute care (PAC) facilities.</AbstractText>Prospective cross-national study</AbstractText>Two hospital geriatric PAC departments: Harzfeld Geriatric Hospital, Gedera,... |
2,333,158 | Is a fall in baseline heart rate a reliable predictor of a successful single shot caudal epidural in children? | This study was designed to investigate whether a fall in heart rate (HR) with injection of local anesthetic into the caudal space can be used as a predictor of correct needle placement.</AbstractText>Two hundred and twenty pediatric patients undergoing infraumbilical surgery were recruited to the study. After induction... |
2,333,159 | Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes. | Extracellular recordings of spontaneous electrical activity in contracting cardiac clusters differentiated from murine embryonic stem cells enable to study electrophysiological features of this in-vitro cardiac-like tissue as well as effects of pharmacological compounds on its chronotropy and electrical conduction. To ... |
2,333,160 | Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. | Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic cardenolide digoxin, as well as the bufadienolides marinobufagenin and telecinobufagin. The physiological effects of endogenous ouabain on blood... |
2,333,161 | Electrical and mechanical effects induced by cold temperatures in the ventricle of isolated Rana ridibunda hearts. | A temperature decrease changes the contractility of the amphibian heart, but the underlying mechanisms are not totally understood. The objectives of the present work were to better understand the intrinsic mechanisms supporting contractility changes induced by a rapid temperature decrease in the ventricle of Rana ridib... |
2,333,162 | Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening. | Acetyl-coenzyme A carboxylase (ACC) enzymes exist as two isoforms, ACC1 and ACC2, which play critical roles in fatty acid biosynthesis and oxidation. Though each isoform differs in tissue and subcellular localization, both catalyze the biotin- and ATP-dependent carboxylation of acetyl-coenzyme A to generate malonyl-coe... |
2,333,163 | Use of mTOR inhibitors in human organ transplantation. | The mammalian target of rapamycin (mTOR) inhibitor drugs rapamycin (sirolimus) and everolimus have undergone extensive clinical trials for a variety of organ grafts and have been licensed for use in human transplantation. Uniquely, they block the function of a master chemical switch, the protein kinase mTOR, which inte... |
2,333,164 | Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo. | We determined the contributions of various endothelium-derived relaxing factors to control of basal vascular tone and endothelium-dependent vasodilation in the mouse hindlimb in vivo. Under anesthesia, catheters were placed in a carotid artery, jugular vein, and femoral artery (for local hindlimb circulation injections... |
2,333,165 | Examining the influence of maternal bradycardia on neonatal outcome using automated data collection. | Due to the increasing number of caesarean sections, we investigated the influence of maternal bradycardia during general and regional anaesthesia on seven standard paediatric outcome parameters using our online recorded data.</AbstractText>Data from 1154 women undergoing caesarean section were investigated prospectivel... |
2,333,166 | Epidural clonidine added to a bupivacaine infusion increases analgesic duration in labor without adverse maternal or fetal effects. | Many obstetric patients receiving epidural analgesia are encouraged to ambulate. This current study was designed to determine the potential for maximizing the time to first epidural supplement when adding clonidine to a 0.625 mg.ml(-1) bupivacaine continuous epidural infusion following epidural fentanyl bolus in early ... |
2,333,167 | Ultrasonographic guidance for sciatic and femoral nerve blocks in children. | Recent studies have shown that ultrasound guidance for paediatric regional anaesthesia can improve the quality of upper extremity and neuraxial blocks. We therefore investigated whether ultrasound guidance for sciatic and femoral nerve blocks prolongs sensory blockade in comparison with nerve stimulator guidance in chi... |
2,333,168 | Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. | Lipid emulsion has been used in the successful treatment of local anaesthetic-induced cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous reports of levobupivacaine toxicity in humans have been characterised by neurological signs and symptoms, without serious cardiovascular events.... |
2,333,169 | Immunomodulation by maternal autoantibodies of the fetal serotoninergic 5-HT4 receptor and its consequences in early BALB/c mouse embryonic development. | The presence of functional 5-HT4 receptors in human and its involvement in neonatal lupus erythematosus (NLE) have prompted us to study the receptor expression and role during embryogenesis. Earlier we managed to demonstrate that female BALB/c mice immunized against the second extracellular loop (SEL) of the 5-HT4 rece... |
2,333,170 | Hypnosis prevents the cardiovascular response to cold pressor test. | To highlight the effects of hypnotic focused analgesia (HFA), 20 healthy participants underwent a cold pressor test (CPT) in waking basal conditions (WBC) by keeping the right hand in icy water until tolerable (pain tolerance); subjective pain was quantified by visual scale immediately before extracting the hand from w... |
2,333,171 | Synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin and their inhibitory action with bovine heart mitochondrial complex I. | The asymmetric total synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin was performed by using an epoxy alcohol as a versatile chiral building block for synthesizing the stereoisomers of mono-THF annonaceous acetogenins. The inhibitory activity of these murisolin comp... |
2,333,172 | Mechanical efficiency and wheelchair performance during and after spinal cord injury rehabilitation. | The purpose of the present study was to investigate whether mechanical efficiency (ME) relates to wheelchair propulsion capacity and wheelchair performance tasks during and after rehabilitation of people with a spinal cord injury (SCI). Eighty participants with a SCI were tested during rehabilitation (3 x) and 1 year a... |
2,333,173 | Cross-sample entropy statistic as a measure of complexity and regularity of renal sympathetic nerve activity in the rat. | In this study, we employed both power spectral analysis and cross-sample entropy measurement to assess the relationship between two time series, arterial blood pressure (ABP) and renal sympathetic nerve activity (RSNA), during a mild haemorrhage in anaesthetized Wistar rats. Removal of 1 ml of venous blood decreased BP... |
2,333,174 | Quantification and MRI validation of regional contractile dysfunction in mice post myocardial infarction using high resolution ultrasound.<Pagination><StartPage>894</StartPage><EndPage>904</EndPage><MedlinePgn>894-904</MedlinePgn></Pagination><Abstract><AbstractText>A versatile, computationally efficient two-dimensiona... | A versatile, computationally efficient two-dimensional (2D) speckle-tracking method based on high resolution ultrasound imaging is proposed to quantify regional myocardial dysfunction in mice. Ultrasound scans were performed on the hearts of normal and post myocardial infarction (MI) mice with a Vevo770 scanner (Visual... |
2,333,175 | Tramadol does not prolong the effect of ropivacaine 7.5 mg/ml for axillary brachial plexus block. | The aim of this prospective, randomized, double-blind study was to evaluate the effect of the addition of tramadol to ropivacaine on the onset and duration of sensory and motor block, and duration of analgesia, for axillary brachial plexus block.</AbstractText>After institutional approval and informed consent had been ... |
2,333,176 | Update of diuretics in the treatment of hypertension. | Diuretics, which are primarily used to modify the volume and the composition of body fluids, are widely used to treat hypertension. The diuretics include a) the thiazides and thiazide-like agents, which are the most common drugs used to treat high blood pressure (these drugs inhibit sodium reabsorption in the early dis... |
2,333,177 | Limited Wegener's granulomatosis--is it limited? | Complete heart block associated with Wegener's granulomatosis (WG) is rare especially in the limited form of the disease. We describe a case of a 43-year-old woman with a limited form of WG who developed a complete heart block. Prompt treatment with steroids and cyclophosphamide led to temporary regression of complete ... |
2,333,178 | An analysis of the effects of stretch on IGF-I secretion from rat ventricular fibroblasts. | Mechanical force can induce a number of fundamental short- and long-term responses in myocardium. These include alterations in ECM, activation of cell-signaling pathways, altered gene regulation, changes in cell proliferation and growth, and secretion of a number of peptides and growth factors. It is now known that a n... |
2,333,179 | Differences in heart rate variability during haemodialysis and haemofiltration. | The aim of our study was to evaluate whether convective (haemofiltration, Hf) and diffusive (haemodialysis, Hd) dialysis techniques induce different patterns of long- and short-term autonomic adjustments in haemodynamically stable dialysis patients.</AbstractText>Ten haemodynamically stable Hd patients were studied. Ea... |
2,333,180 | Adenoviral-mediated expression of dihydropyridine-insensitive L-type calcium channels in cardiac ventricular myocytes and fibroblasts. | Cardiac voltage-gated Ca2+ channels regulate the intracellular Ca2+ concentration and are therefore essential for muscle contraction, second messenger activation, gene expression and electrical signaling. As a first step in accessing the structural versus functional properties of the L-type Ca2+ channel in the heart, w... |
2,333,181 | Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish. | The vertebrate body plan is generated during gastrulation with the formation of the three germ layers. Members of the Nodal-related subclass of the TGF-beta superfamily induce and pattern the mesoderm and endoderm in all vertebrates. In zebrafish, two nodal-related genes, called squint and cyclops, are required in a do... |
2,333,182 | Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes. | Embryonic stem cell-derived cardiomyocytes (ESdCs) have been proposed as a source for cardiac cell-replacement therapy. The aim of this study was to determine the Ca2+-handling mechanisms that determine the frequency and duration of spontaneous Ca2+ transients in single ESdCs. With laser scanning confocal microscopy us... |
2,333,183 | Laparoscopic cholecystectomy under segmental thoracic spinal anaesthesia: a feasibility study. | Laparoscopic surgery is normally performed under general anaesthesia, but regional techniques have been found beneficial, usually in the management of patients with major medical problems. Encouraged by such experience, we performed a feasibility study of segmental spinal anaesthesia in healthy patients.</AbstractText>... |
2,333,184 | Postoperative analgesia with intravenous fentanyl PCA vs epidural block after thoracoscopic pectus excavatum repair in children. | The aim of this prospective, randomized trial was to compare analgesia, sedation, and cardiorespiratory function in children after thoracoscopic surgery for pectus excavatum repair, using two types of analgesia--epidural block with bupivacaine plus fentanyl vs patient-controlled analgesia (PCA) with fentanyl.</Abstract... |
2,333,185 | Ropivacaine versus lidocaine for deep-topical, nerve-block anaesthesia in cataract surgery: a double-blind randomized clinical trial. | To evaluate the safety and efficacy of ropivacaine versus lidocaine for deep-topical, nerve-block anaesthesia in cataract surgery.</AbstractText>This prospective controlled randomized double-blind study comprised 64 patients undergoing clear corneal phacoemulsification. Patients were equally divided into two group rece... |
2,333,186 | Nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type II. | To report a case of nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type II (APS-II).</AbstractText>We describe our patient's clinical features, evaluation, and outcome. In addition, a literature review of cardiomyopathy associated with polyendocrinopathy syndromes is presented.</AbstractTe... |
2,333,187 | The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. | Intracellular Na(+) concentration ([Na(+)](i)) rises in the heart during ischemia, and on reperfusion, there is a transient rise followed by a return toward control. These changes in [Na(+)](i) contribute to ischemic and reperfusion damage through their effects on Ca(2+) overload. Part of the rise of [Na(+)](i) during ... |
2,333,188 | Correlation between salivary alpha-amylase activity and pain scale in patients with chronic pain. | The visual analog scale (VAS) is commonly used to assess pain intensity. However, the VAS is of limited value if patients fail to reliably report. Objective assessments are therefore clearly preferable. Previous reports suggest that elevated salivary alpha-amylase may reflect increased physical stress. There is a close... |
2,333,189 | Comparison of 0.25% levobupivacaine, 0.25% bupivacaine, and 0.125% bupivacaine for duration and magnitude of action in peripheral arterial blood flow induced by sympathetic block in dogs. | The aim of this study is to compare 0.25% levobupivacaine with 0.25% bupivacaine and 0.125% bupivacaine to examine the duration and magnitude of vasodilative effect induced by sympathetic block.</AbstractText>We measured mean arterial pressure (MAP), heart rate (HR), and right and left brachial-artery blood flow (BABF)... |
2,333,190 | Vasopressin dysregulation: hyponatremia, fluid retention and congestive heart failure. | Arginine vasopressin (AVP) plays a central role in the regulation of water and electrolyte balance. Dysregulation of AVP secretion, along with stimulation of AVP V2 receptors, is responsible for hyponatremia (serum sodium concentration <135 mEq/L) in congestive heart failure (CHF). The stimulation of atrial and arte... |
2,333,191 | Electrocardiography: the ECG. | This article examines the role of electrocardiography in patient monitoring during an operative procedure. In addition to providing a wealth of physiological information, including information on the electrical activity of the heart, the ECG assists in monitoring and detecting a variety of changes, such as cardiac arrh... |
2,333,192 | Heart rate and blood pressure variability as markers of sensory blockade with labour epidural analgesia. | To evaluate the correlation between the progression of somatosensory blockade and changes in autonomic outflow following the onset of labour epidural analgesia.</AbstractText>Twelve labouring parturients consented to participate in the study. Baseline electrocardiogram, blood pressure (BP) and respiratory rate were rec... |
2,333,193 | A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. | The potential pathophysiological role of common SCN5A polymorphisms in cardiac arrhythmias has been increasingly recognized. However, little is known about the impact of those polymorphisms on the pharmocological response of hNav1.5 to various antiarrhythmic agents.</AbstractText>The known SCN5A polymorphism, S524Y, wa... |
2,333,194 | Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers.<Pagination><StartPage>719</StartPage><EndPage>728</EndPage><MedlinePgn>719-28</MedlinePgn></Pagination><Abstract><AbstractText>Methadone inhibits the cardiac potassium channel hERG and can cause a prolonged ... | Methadone inhibits the cardiac potassium channel hERG and can cause a prolonged QT interval. Methadone is chiral but its therapeutic activity is mainly due to (R)-methadone. Whole-cell patch-clamp experiments using cells expressing hERG showed that (S)-methadone blocked the hERG current 3.5-fold more potently than (R)-... |
2,333,195 | Percussion pacing--an almost forgotten procedure for haemodynamically unstable bradycardias? A report of three case studies and review of the literature. | More than 80 years after its first description by Eduard Schott, percussion (fist) pacing remains a little known procedure even though it represents an instantly available and easy to perform treatment for temporary emergency cardiac pacing in haemodynamically unstable bradycardias, including bradycardic pulseless elec... |
2,333,196 | [Hyperbaric bupivacaine: a randomized double-blind trial of different doses with or without fentanyl for cesarean section under spinal anesthesia]. | To compare the effects of spinal anesthesia with different doses of hyperbaric bupivacaine with or without fentanyl in patients undergoing cesarean section.</AbstractText>Prospective study enrolling 50 ASA 1-2 patients undergoing cesarean section, randomized to 5 treatment groups. Groups A, B, C, and D received 15 micr... |
2,333,197 | Persistence of PAR-2 vasodilation despite endothelial dysfunction in BPH/2 hypertensive mice. | This study investigated relaxation of vascular smooth muscle by acetylcholine, bradykinin and protease-activated receptor 2 (PAR-2) to characterise endothelial dysfunction in spontaneously hypertensive mice (BPH/2). We hypothesised that PAR-2 induced vasodilation would be preserved in BPH/2 despite the presence of hype... |
2,333,198 | Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. | We previously reported that overexpression of cell division autoantigen 1 (CDA1) in HeLa cells arrests cell growth and inhibits DNA synthesis at S-phase. Here we show that CDA1-induced arrest of cell growth is accompanied by increases in protein and mRNA levels of the cyclin-dependent kinase (Cdk) inhibitor protein, p2... |
2,333,199 | Observations on the muscle relaxant rocuronium bromide in the horse--a dose-response study. | To investigate the onset and duration of neuromuscular blockade of rocuronium bromide and its associated haemodynamic effects at three doses in healthy horses.</AbstractText>Prospective, randomized experimental study.</AbstractText>Seven adult horses aged 3-20 (mean 10.3) years and weighing 466 +/- 44 (mean +/- SD) kg.... |
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