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2,333,800 | Calreticulin negatively regulates the surface expression of Cav1.3 L-type calcium channel. | The neuroendocrine Cav1.3 L-type Ca channels have been recently found in the Human fetal heart and shown to play a vital role in Ca entry from the sarcolemma into the cell and in Ca homeostasis. Calreticulin, a Ca binding endoplasmic reticulum (ER) resident protein, has been recently shown to translocate to the cell su... |
2,333,801 | Elastic image registration to quantify 3-D regional myocardial deformation from volumetric ultrasound: experimental validation in an animal model. | Although real-time 3-D echocardiography has the potential to allow more accurate assessment of global and regional ventricular dynamics compared with more traditional 2-D ultrasound examinations, it still requires rigorous testing and validation should it break through as a standard examination in routine clinical prac... |
2,333,802 | Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade. | Local anesthetic systemic toxicity (LAST) is a potentially life-threatening complication of local anesthetic administration. In this article, the results of the Australian and New Zealand Registry of Regional Anaesthesia were analyzed to determine if ultrasound-guided peripheral nerve blockade (PNB) was associated with... |
2,333,803 | Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial. | Catheter-based renal artery sympathetic denervation has emerged as a novel therapy for treatment of patients with drug-resistant hypertension. Initial studies were performed using a single electrode radiofrequency catheter, but recent advances in catheter design have allowed the development of multi-electrode systems t... |
2,333,804 | Fat and carbohydrate metabolism during exercise in phosphoglucomutase type 1 deficiency. | Phosphoglucomutase type 1 (PGM1) deficiency is a rare metabolic myopathy in which symptoms are provoked by exercise.</AbstractText>Because the metabolic block is proximal to the entry of glucose into the glycolytic pathway, we hypothesized that iv glucose could improve the exercise intolerance experienced by the patien... |
2,333,805 | [Case of parturient who underwent resection of a spinal Tumor]. | Spinal tumors are rare in pregnancy, but they cause a serious problem in terms of continuing pregnancy. Here, we present a parturient with severe lumbago who underwent resection of a spinal tumor. A 42-year-old parturient at 26 weeks of gestation presented with acute onset of severe pain in the lumbar region and lower ... |
2,333,806 | Nox as a target for diabetic complications. | Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox signalling in cells from different organs afflicted b... |
2,333,807 | High gender -specific susceptibility to curare- a neuromuscular blocking agent. | Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, b... |
2,333,808 | Myeloid leukemia in a urine specimen: a case report and review of the literature. | Urinary tract cytology has a long history of utilization for the diagnosis and follow-up of tumors involving the urothelial tract. As expected, the most common tumor encountered in exfoliative urine cytology is urothelial carcinoma. While the sensitivity of urinary tract cytology for the diagnosis of low-grade urotheli... |
2,333,809 | Nanoscale distribution of ryanodine receptors and caveolin-3 in mouse ventricular myocytes: dilation of t-tubules near junctions. | We conducted super-resolution light microscopy (LM) imaging of the distribution of ryanodine receptors (RyRs) and caveolin-3 (CAV3) in mouse ventricular myocytes. Quantitative analysis of data at the surface sarcolemma showed that 4.8% of RyR labeling colocalized with CAV3 whereas 3.5% of CAV3 was in areas with RyR lab... |
2,333,810 | Effect of interscalene brachial plexus block on heart rate variability. | Interscalene brachial plexus block (ISB) may be followed by cardiovascular instability. Until date, there is no clear picture available about the underlying mechanisms of ISB. In this study, we aimed to determine the changes in heart rate variability (HRV) parameters after ISB and the differences between right- and lef... |
2,333,811 | Effect of retrobulbar nerve block on heart rate variability during enucleation in horses under general anesthesia. | Analysis of any effect of retrobulbar block during ocular surgery on heart rate variability and oculocardiac reflex.</AbstractText>Prospective study.</AbstractText>Horses (n = 16) undergoing eye enucleation due to chronic ophthalmologic diseases.</AbstractText>Eye enucleation was performed under general anesthesia. The... |
2,333,812 | Interfering amino terminal peptides and functional implications for heteromeric gap junction formation. | Connexin43 (Cx43) is widely expressed in many different tissues of the human body. In cells of some organs, Cx43 is co-expressed with other connexins (Cx), including Cx46 and Cx50 in lens, Cx40 in atrium, Purkinje fibers, and the blood vessel wall, Cx45 in heart, and Cx37 in the ovary. Interactions with the co-expresse... |
2,333,813 | Outcome of pregnancy in Italian patients with primary Sjögren syndrome. | To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS).</AbstractText>An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS... |
2,333,814 | Hemodynamic, ventilator, and ECG changes in pediatric patients undergoing extraction. | Dental treatment induces pain anxiety and fear. This study was conducted to assess the changes in hemodynamic, ventilator, and electrocardiograph changes during extraction procedure among 12-15-year-old children and compare these changes with anxiety, fear, and pain.</AbstractText>A purposive sample of 60 patients sele... |
2,333,815 | The effects of dexmedetomidine added to spinal levobupivacaine for transurethral endoscopic surgery. | Intrathecal α2 agonists prolong the duration of action of local anesthetics and reduce the required dose. Dexmedetomidine is an α2 receptor agonist and its α2/α1 selectivity is 8 times higher than that of clonidine.</AbstractText>In this study, we aimed to investigate the effect of adding dexmed... |
2,333,816 | Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate. | Agents having a positive inotropic effect on the heart are widely used for the treatment of heart failure. However, these agents have the side effect of altering heart rate. It has been established that peroxisome proliferator-activated receptor δ (PPARδ) is mediated in cardiac contraction, however the effe... |
2,333,817 | Adaptive Kaczmarz method for image reconstruction in electrical impedance tomography. | We present an adaptive Kaczmarz method for solving the inverse problem in electrical impedance tomography and determining the conductivity distribution inside an object from electrical measurements made on the surface. To best characterize an unknown conductivity distribution and avoid inverting the Jacobian-related te... |
2,333,818 | Anesthetic efficacy of X-tip intraosseous injection using 2% lidocaine with 1:80,000 epinephrine in patients with irreversible pulpitis after inferior alveolar nerve block: A clinical study. | The inferior alveolar nerve block (IAN) is the most frequently used mandibular injection technique for achieving local anesthesia in endodontics. Supplemental injections are essential to overcome failure of IAN block in patients with irreversible pulpitis.</AbstractText>To evaluate the anesthetic efficacy of X-tip intr... |
2,333,819 | Functional morphometric analysis in cellular behaviors: shape and size matter. | Cellular morphogenesis in response to biophysical and topographical cues provides insights into cytoskeletal status, biointerface communications, and phenotypic adaptations in an incessant signaling feedback that governs cellular fate. Morphometric characterization is an important element in the study of the dynamic ce... |
2,333,820 | Glossopharyngeal neuralgia. | In this review, the clinical characteristics, differentiating features from other forms of neuralgia, etiology and treatment options of glossopharyngeal neuralgia will be discussed. |
2,333,821 | Consumers' estimation of calorie content at fast food restaurants: cross sectional observational study. | To investigate estimation of calorie (energy) content of meals from fast food restaurants in adults, adolescents, and school age children.</AbstractText>Cross sectional study of repeated visits to fast food restaurant chains.</AbstractText>89 fast food restaurants in four cities in New England, United States: McDonald'... |
2,333,822 | Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach. | Due to many favourable attributes adenoviruses (Ads) are the most extensively used vectors for clinical gene therapy applications. However, following intravascular administration, the safety and efficacy of Ad vectors are hampered by the strong hepatic tropism and induction of a potent immune response. Such effects are... |
2,333,823 | In silico assessment of drug safety in human heart applied to late sodium current blockers. | Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which may block different channels, remains an important opportunity. Partial block of the late sodium c... |
2,333,824 | The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity. | Pyruvate is a metabolic fuel that is a potent inotropic agent. Despite its unique inotropic and antioxidant properties, the molecular mechanism of its inotropic mechanism is still largely unknown. To examine the inotropic effect of pyruvate in parallel with intracellular calcium handling under near physiological condit... |
2,333,825 | Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene. | Focal segmental glomerulosclerosis (FSGS) is the consequence of a disease process that attacks the kidney's filtering system, causing serious scarring. More than half of FSGS patients develop chronic kidney failure within 10 years, ultimately requiring dialysis or renal transplantation. There are currently several gene... |
2,333,826 | Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: a review of published literature and registered clinical trials. | Offspring of women with anti-SSA/Ro-SSB/La antibodies are believed to be at risk for congenital heart block (CHB). Whether this risk can be reduced, and what constitutes standard of care treatment is, however, unclear. The objective of this review therefore was to determine whether currently proposed standard of care t... |
2,333,827 | Suppression of cardiac alternans by alternating-period-feedback stimulations. | Alternans response, comprising a sequence of alternating long and short action potential durations in heart tissue, seen during rapid periodic pacing can lead to conduction block resulting in potentially fatal cardiac failure. A method of pacing with feedback control is proposed to reduce the alternans and therefore th... |
2,333,828 | Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure. | Bisphenol A (BPA) is a widespread endocrine-disrupting chemical used as the building block for polycarbonate plastics. Epidemiological evidence has correlated BPA exposure with higher risk of heart disease and type 2 diabetes. However, it remains unknown whether there are critical windows of susceptibility to BPA expos... |
2,333,829 | Population trends and variation in body mass index from 1971 to 2008 in the Framingham Heart Study Offspring Cohort. | We examined body mass index (BMI) across place and time to determine the pattern of BMI mean and standard deviation trajectories.</AbstractText>We included participants in the Framingham Heart Study (FHS) Offspring Cohort over eight waves of follow-up, from 1971 to 2008. After exclusions, the final sample size was 4569... |
2,333,830 | Prostaglandins and prostaglandin receptor antagonism in migraine. | Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induc... |
2,333,831 | Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels. | Duloxetine is a selective serotonin-noradrenaline reuptake inhibitor approved for treatment of major depressive disorder. So far, duloxetine has been found to be well tolerated and reported cardiac side effects were negligible. However, pharmacological effects on cardiac hERG channels have not been properly addressed y... |
2,333,832 | Efficient transduction of human hematopoietic repopulating cells with a chimeric HIV1-based vector including SIV capsid. | Innate immune factors, such as TRIM5α and cyclophilin A (CypA), act as a major restriction factor of retroviral infection among species. When HIV1 infects human cells, HIV1 capsid binds to human CypA to escape from human TRIM5α restriction. However, in rhesus cells, the mismatch between HIV1 capsid and rhes... |
2,333,833 | Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels. | About a decade ago, the molecular determinants controlling the opening and closing of Cx43 gap junction channels have been identified. Advanced biophysical approaches revealed a critical role for structural rearrangements in the cytoplasmic loop and dimerization of the C-terminal tail, resulting in binding of the C-ter... |
2,333,834 | Heart rate responses to temperature in free-swimming Pacific bluefin tuna (Thunnus orientalis). | The bluefin tuna heart remains at ambient water temperature (Ta) but must supply blood to warm regions of the body served by countercurrent vascular heat exchangers. Despite this unusual physiology, inherent difficulties have precluded an understanding of the cardiovascular responses to Ta in free-swimming bluefin tuna... |
2,333,835 | Maternal and neonatal outcomes in pregnancies complicated by systemic lupus erythematosus: a population-based study.<Pagination><StartPage>323</StartPage><EndPage>328</EndPage><MedlinePgn>323-328</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1701-2163(15)30959-2</ELocationID><ELocationID EIdT... | Objectif : Déterminer les issues maternelles et néonatales dans les cas de grossesse compliquée par le lupus érythémateux disséminé (LED). Méthodes : Dans le cadre d’une étude de cohorte rétrospective menée au moyen de la Nova Scotia Atlee Perinata... |
2,333,836 | Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk? | To examine the recent advances in our knowledge of cholesteryl ester transfer protein (CETP) inhibitors, heart disease risk reduction, and human lipoprotein metabolism.</AbstractText>CETP inhibitors block the transfer of cholesteryl ester from HDLs to triglyceride-rich lipoproteins (TRLs), thereby raising HDL cholester... |
2,333,837 | Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment. | Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of automated and high-throughput screeni... |
2,333,838 | [Effect of electroacupuncture combined with cervical plexus block on stress responses in patients undergoing thyroid surgery]. | To observe the effect of electroacupuncture (EA) combined with cervical plexus block (CPB) on the stress response of patients undergoing thyroid surgery.</AbstractText>Forty thyroidectomy patients were randomly divided into sham EA plus CPB group (sham group) and EA+CPB group (20 cases in each group). For patients of t... |
2,333,839 | Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method. | We have determined the molar proportions of the MUC5AC and MUC6 mucus glycoproteins (mucins) in mucus from the normal and pathological human gastric antrum using a least-squares minimization analysis applied to amino acid compositions. We noted that the content of MUC5AC mucin in mucus from individuals without gastrodu... |
2,333,840 | Percutaneous autonomic neural modulation: a novel technique to treat cardiac arrhythmia. | Ablation and anti-arrhythmic medications have shown promise but have been met with varying success and unwanted side effects such as myocardial injury, arrhythmias, and morbidity from invasive surgical intervention. The answer to improving efficacy of ablation may include modulation of the cardiac aspect of the autonom... |
2,333,841 | Ion pumps as biological targets for decavanadate. | The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a role in the treatment of e.g. ulcers, cancer and ischemic heart dise... |
2,333,842 | A comparative study of hemodynamic changes between prone and supine emergence from anesthesia in lumbar disc surgery. | Supine emergence from anesthesia in patients undergoing lumbar surgery in prone position leads to tachycardia, hypertension, coughing, laryngospasm and loss of monitoring as the patients are rolled back to supine position at the end of surgery. The prone extubation might facilitate a smoother emergence because the pati... |
2,333,843 | Intraoperative conditions and quality of postoperative analgesia after adding dexmedetomidine to epidural bupivacaine and fentanyl in elective cesarean section using combined spinal-epidural anesthesia. | This study was designed to evaluate the effect of adding dexmedetomidine to regular mixture of epidural drugs for pregnant women undergoing elective cesarean section with special emphasis on their sedative properties, ability to improve quality of intraoperative, postoperative analgesia, and neonatal outcome.</Abstract... |
2,333,844 | The mechanistic action of carbon dioxide on a neural circuit and NMJ communication. | Previous studies examining behavioral responses to CO(2) revealed that high [CO(2)] acts as a natural repellent in a concentration dependent manner for crayfish. Physiologically, CO(2) can rapidly block the autonomic responses in heart rate, as well as, inhibit an escape tail flip reflex in crayfish. Here, we demonstra... |
2,333,845 | Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth. | The purpose of this study is to investigate the antinociceptive effects of ginsenosides on toothache. c-Fos immunoreactive (IR) neurons were examined after noxious intrapulpal stimulation (NS) by intrapulpal injection of 2 M KCl into upper and lower incisor pulps exposed by bone cutter in Sprague Dawley rats. The numbe... |
2,333,846 | Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. | In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK₁) is thought to set the negative and stable resting membrane potential, and contributes to action potential repolarization. Loss- or gain-of-function mutations correlate with cardiac arrhythmias and pathological remodelling affects norma... |
2,333,847 | Increased electrical nerve stimulation threshold of the sciatic nerve in patients with diabetic foot gangrene: a prospective parallel cohort study. | Peripheral neuropathy may affect nerve conduction in patients with diabetes mellitus.</AbstractText>This study was designed to test the hypothesis that the electrical stimulation threshold for a motor response of the sciatic nerve is increased in patients suffering from diabetic foot gangrene compared to non-diabetic p... |
2,333,848 | The role of 17-beta estradiol in ischemic preconditioning protection of the heart. | The protective effects of 17-beta estradiol (E2) on cardiac tissue during ischemia/reperfusion (I/R) injury have not yet been fully elucidated.</AbstractText>To assess the protective effects of short- and long-term E2 treatments on cardiac tissue exposed to I/R, and to assess the effects of these treatments in combinat... |
2,333,849 | Inhibitory effect of glybenclamide on mitochondrial chloride channels from rat heart. | Glybenclamide is used as a pharmacological tool in studies of mitochondrial functions supposing its main role to block ATP-dependent potassium (KATP) channel. The aim of this study was to test whether glybenclamide might interact with the mitochondrial chloride channels. Mitochondrial membranes, isolated from rat heart... |
2,333,850 | CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction. | Chemokines and neutrophils, known as important players in the inflammatory cascade, also contribute to heart tissue recovery and scar formation after myocardial infarction (MI). The objective of this study was to determine the importance of ELR-containing CXC chemokine KC in neutrophil infiltration and neoangiogenesis,... |
2,333,851 | [The comparison of epidural continuous infusion and epidural patient controlled bolus administration in labor analgesia]. | We aimed to compare the efficacies of patient controlled bolus administration and continuous infusion of low dose Fentanyl and Levobupivacaine combination by epidural catheter during vaginal labor on mother, baby and the duration of labor.</AbstractText>The 45 pregnant women involved in the study were divided randomly ... |
2,333,852 | Artemisia copa aqueous extract as vasorelaxant and hypotensive agent. | Artemisia copa Phil. (Asteraceae) is a medicinal plant commonly used in traditional medicine in Argentina.</AbstractText>The vasorelaxant and hypotensive activities of the aqueous extract of Artemisia copa have been investigated.</AbstractText>The in vitro effect of the extract and isolated compounds from Artemisia cop... |
2,333,853 | Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs. | Effective chemical compound toxicity screening is of paramount importance for safe cardiac drug development. Using mammals in preliminary screening for detection of cardiac dysfunction by electrocardiography (ECG) is costly and requires a large number of animals. Alternatively, zebrafish embryos can be used as the ECG ... |
2,333,854 | Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque. | Endothelial dysfunction is considered to play a key role in the development of atherosclerosis. However, only a limited number of human imaging studies have been available to demonstrate this hypothesis. The present study used near-infrared spectroscopy (NIRS) to investigate whether coronary endothelial dysfunction is ... |
2,333,855 | Vitamin D toxicity presenting as hypercalcemia and complete heart block: An interesting case report. | Vitamin D deficiency is widely prevalent across the globe. This has lead to widespread use of vitamin D supplements in populations. We present our experience of vitamin D toxicity in a subject resulting in hypercalcemia and CHB (Complete Heart Block). A 70-year-old female, known hypertensive for thirty five years and d... |
2,333,856 | Mechanisms of [Ca2+]i elevation following P2X receptor activation in the guinea-pig small mesenteric artery myocytes. | There is growing evidence suggesting involvement of L-type voltage-gated Ca2+ channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay between VGCCs and P2X receptors in intracellular Ca2+ mobilization is not well understood. This study examined relative contribution of the Ca2+ entry mechanisms... |
2,333,857 | Effect of position changes after spinal anesthesia with low-dose bupivacaine in elderly patients: sensory block characteristics and hemodynamic changes. | The purpose of this study is to compare the anesthetic characteristics in elderly patients who remain in sitting position for 2 min compared with patients that are placed in supine position after induction of spinal anesthesia.</AbstractText>Fifty-seven patients scheduled for transurethral surgery were randomized to as... |
2,333,858 | Cardiac ion channel trafficking defects and drugs. | Fine control over the functional expression of cardiac ion channels is required to maintain normal action potential (AP) duration and QTc times. A growing number of drugs interfere with normal trafficking of ion channels to and from the plasma membrane, thereby altering the number of channels on the cell surface. Most ... |
2,333,859 | Cardicola langeli sp. n. (Digenea: Aporocotylidae) from heart of sheepshead, Archosargus probatocephalus (Actinopterygii: Sparidae) in the Gulf of Mexico, with an updated list of hosts, infection sites and localities for Cardicola spp. | Cardicola langeli n. sp. (Digenea: Aporocotylidae) infects the heart of sheepshead, Archosargus probatocephalus (Walbaum, 1792) (Perciformes: Sparidae) in the northern Gulf of Mexico off Horn Island (type locality), Mississippi, USA. The new species is described herein using light and scanning electron microscopy of ad... |
2,333,860 | Phenylephrine as a simulated intravascular epidural test dose in pediatrics: a pilot study. | A test dose is used to detect intravascular injection during neuraxial block in pediatrics. Accidental intravascular epidural local anesthetic injection might be unrecognized in anesthetized children leading to potential life-threatening complications. In children, sevoflurane anesthesia blunts the hemodynamic response... |
2,333,861 | Assessment of maxillary and infraorbital nerve blockade for rhinoscopy in sevoflurane anesthetized dogs. | To investigate the efficacy of maxillary and infraorbital nerve blocks for prevention of cardiovascular and qualitative responses to rhinoscopy, as well as response to skin clamping after assigned nerve block placement.</AbstractText>Randomized, blinded, placebo-controlled cross-over experimental study.</AbstractText>E... |
2,333,862 | Cardiovascular Protective Effects of Adjunctive Alternative Medicine (Salvia miltiorrhiza and Pueraria lobata) in High-Risk Hypertension. | Introduction. Hypertension in association with diabetes (DM), renal impairment (RI), and left ventricular hypertrophy (LVH) increases the risk of future cardiovascular events. We hypothesize, traditional herbal medicines Danshen and Gegen (D&G) have beneficial effects on atherogenesis in these high-risk hypertensiv... |
2,333,863 | The effect of oxygen administration on regional cerebral oxygen saturation after stellate ganglion block on the non-blocked side. | Stellate ganglion block (SGB) causes sympathetic denervation of the head, neck, and upper extremities. In some studies, it has been reported that cerebral blood flow on the non-blocked side decreases after SGB, so when performing an SGB for pain management of the head, neck, and arm, the increased risk of cerebral isch... |
2,333,864 | Influence of an intra-articular lipopolysaccharide challenge on markers of inflammation and cartilage metabolism in young horses. | Nineteen weanling Quarter Horses (225 to 380 kg) were used in a randomized complete block design to investigate the effects of intra-articular lipopolysaccharide (LPS) to induce acute joint inflammation in young horses. Horses were blocked by age, BW, and sex and were randomly assigned to 1 of 3 treatments for a 35-d e... |
2,333,865 | Exercise intolerance in Glycogen Storage Disease Type III: weakness or energy deficiency? | Myopathic symptoms in Glycogen Storage Disease Type IIIa (GSD IIIa) are generally ascribed to the muscle wasting that these patients suffer in adult life, but an inability to debranch glycogen likely also has an impact on muscle energy metabolism. We hypothesized that patients with GSD IIIa can experience exercise into... |
2,333,866 | Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients.<Pagination><StartPage>194</StartPage><EndPage>201</EndPage><MedlinePgn>194-201</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.12659/MSM.883833</ELocationID><Abstract><AbstractText Label="BACKGROUND" ... | Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting millions of individuals worldwide. The rapid, irregular, and disordered electrical activity in the atria gives rise to palpitations, fatigue, dyspnea, chest pain and dizziness with or without syncope. Patients with AF have a five-fold h... |
2,333,867 | Impact of subcutaneous infiltration of 0.5% bupivacaine on post-operative C-reactive protein serum titer after craniotomy surgery. | Tissue injuries may provoke neuro-hormonal response which in turn may lead to release of inflammatory cytokines. We hypothesize that block of afferent sensory pathways by infiltration of 0.5% bupivacaine in the scalp may decrease neuro-hormonal response in the neurosurgical patient.</AbstractText>After obtaining inform... |
2,333,868 | High-frequency transcutaneous electrical nerve stimulation reduces pain and cardio-respiratory parameters in an animal model of acute pain: participation of peripheral serotonin. | The objective of this study was to investigate the effect of high-frequency transcutaneous electrical nerve stimulation (HF-TENS) in antihyperalgesia, assessed through changes of sciatic nerve activity and its effects on cardiorespiratory parameters, using formalin-induced nociception in anesthetized rats. The animals ... |
2,333,869 | Cerebral aqueduct block attenuates cardio-renal injuries in post-DOCA-NaCl-hypertensive Dahl R rats. | The systemic and/or local effects of the hydrocephalic brain were investigated in DOCA-NaCl-hypertensive Dahl R rats induced by 250 mg kg(-1) DOCA in silicone and 1% saline water. After a 1-week recovery with 0.3% NaCl chow and tap water, one group had the aqueduct of Sylvius blocked with silicone and epoxy materials w... |
2,333,870 | Worsening Wenckebach after calcium gluconate injection: not uncommon but frequently missed diagnosis. | The objective of the study is to demonstrate a common etiology of hyperkalemia and illustrate a potential iatrogenic errors in treatment. |
2,333,871 | Episodic irregular tachycardia and AV block causing bradycardia: what is the mechanism?<Pagination><StartPage>834</StartPage><EndPage>836</EndPage><MedlinePgn>834-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jce.12113</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dop... | The incidence of diabetes is increasing rapidly as the percentage of the population ages and becomes more obese. According to the National Center for Health Statistics diabetes is now the sixth leading cause of death in the US. The biguanide metformin is typically the first-line medication used for treatment of type 2 ... |
2,333,872 | A comparison of the haemodynamic effects of lateral and sitting positions during induction of spinal anaesthesia for caesarean section. | Hypotension during spinal anaesthesia occurs commonly in parturients. By influencing spread of local anaesthetic, maternal position may affect the speed of onset of sensory block and thus the haemodynamic effects. The aim of this study was to determine whether inducing spinal anaesthesia for caesarean section using pla... |
2,333,873 | Magnetic resonance imaging analysis of the spread of local anesthetic solution after ultrasound-guided lateral thoracic paravertebral blockade: a volunteer study. | This study was designed to examine the spread of local anesthetic (LA) via magnetic resonance imaging after a standardized ultrasound-guided thoracic paravertebral blockade.</AbstractText>Ten volunteers were enrolled in the study. We performed ultrasound-guided single-shot paravertebral blocks with 20 ml mepivacaine 1%... |
2,333,874 | The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias. | Electrophysiological heterogeneity in action potential recordings from healthy intact hearts remains highly variable and, where present, is almost entirely abolished at fast pacing rates. Consequently, the functional importance of intrinsic action potential duration (APD) heterogeneity in healthy ventricles, and partic... |
2,333,875 | Infantile facioscapulohumeral muscular dystrophy revisited: Expansion of clinical phenotypes in patients with a very short EcoRI fragment. | Contrary to the classical form, infantile facioscapulohumeral muscular dystrophy (FSHD) usually denotes a severe phenotype and is frequently associated with extramuscular involvements. To elucidate the genotype-phenotype correlation in this severe subgroup, we identified a cohort of nine patients with infantile FSHD wh... |
2,333,876 | Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome. | Brugada syndrome is a heterogeneous heart rhythm disorder characterized by an atypical right bundle block pattern with ST-segment elevation and T-wave inversion in the right precordial leads. Loss-of-function mutations in SCN5A encoding the cardiac sodium channel Na(V)1.5 are associated with Brugada syndrome. We found ... |
2,333,877 | MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. | Loss-of-function mutations in Na(v)1.5 cause sodium channelopathies, including Brugada syndrome, dilated cardiomyopathy, and sick sinus syndrome; however, no effective therapy exists. MOG1 increases plasma membrane (PM) expression of Na(v)1.5 and sodium current (I(Na)) density, thus we hypothesize that MOG1 can serve a... |
2,333,878 | Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart. | Significant circadian variations exist in the frequency of cardiac arrhythmia, but few studies have examined the relation between cardiac ion channels genes and biological clocks. We investigated this relation using suprachiasmatic nuclei lesion (SCNX) and pharmacological autonomic nervous system block (ANSB) mice. Sig... |
2,333,879 | Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. | Post-menopausal women show dramatically increased cardiovascular disease morbidity (CVD). Danshen is used widely in China for the treatment of cardiovascular disorders, including coronary heart disease. Danshen possesses lipid-soluble biologically active components with a structure similar to 17β-estrodiol (E2). ... |
2,333,880 | Lipids in local anesthetic toxicity. | With the advent of long-lasting local anesthetics, local and regional anesthesia gained considerable impetus and the use of these techniques has become increasingly widespread. New block techniques have been described and regional anesthesia is frequently associated with general anesthesia to provide postoperative anal... |
2,333,881 | The response of the composite variability index to a standardized noxious stimulus during propofol-remifentanil anesthesia. | Recently the Composite Variability Index (CVI) was developed to quantify nociception. This index is derived from the standard deviations (s) of the Bispectral Index (sBIS) and the electromyogram (sEMG). The primary aim of our study was to compare CVI before and after a noxious stimulus. As secondary end points, we inve... |
2,333,882 | Prolongation of PR interval is associated with endothelial dysfunction and activation of vascular repair in high-risk cardiovascular patients. | Epidemiological studies showed that PR prolongation is associated with increased risk of adverse cardiovascular outcomes. We investigated the relations of PR interval with indices of vascular function and endothelial repair as the underlying mechanisms.</AbstractText>The study comprised 348 high-risk patients with prio... |
2,333,883 | Changes in cerebral blood flow and vasoreactivity to CO2 measured by arterial spin labeling after 6days at 4350m. | Changes in cerebral perfusion and CO2 cerebrovascular reactivity during and immediately after a sojourn at high altitude remain unclear but may be critical for acclimatization. The aim of the present study was to assess the effects of 6days at 4350m on cerebral perfusion and cerebrovascular reactivity (CVR) to CO2 by a... |
2,333,884 | Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs no neuromuscular block. | There have been no evidence-based comparisons of motor-evoked potential (MEP) monitoring with no and partial neuromuscular block (NMB). We compared the effects of different levels of NMB including no NMB on MEP parameters.</AbstractText>MEP-monitored 120 patients undergoing neurosurgery were enrolled. The patients were... |
2,333,885 | Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor. | Firemaster 550 (FM550) is an additive flame retardant formulation of brominated and aryl phosphate ester (APE) components introduced as a major replacement product for the commercial polybrominated diphenyl ether mixture (known as PentaBDE) used primarily in polyurethane foam. However, little is known about the potenti... |
2,333,886 | Expression of coxsackievirus and adenovirus receptor (CAR)-Fc fusion protein in Pichia pastoris and characterization of its anti-coxsackievirus activity. | Coxsackievirus and adenovirus receptors (CARs) are the common cellular receptors which mediate coxsackievirus or adenovirus infection. Receptor trap therapy, which uses soluble viral receptors to block the attachment and internalization of virus, has been developed for the inhibition of virus infection. In this study, ... |
2,333,887 | Pediatric systems medicine: evaluating needs and opportunities using congenital heart block as a case study. | Medicine and pediatrics are changing and health care is moving from being reactive to becoming preventive. Despite rapid developments of new technologies for molecular profiling and systems analysis of diseases, significant hurdles remain. Here, we use the clinical setting of congenital heart block (CHB) to uncover and... |
2,333,888 | Where are lifesaving automated external defibrillators located and how hard is it to find them in a large urban city? | Automated external defibrillators (AEDs) are lifesaving, but little is known about where they are located or how to find them. We sought to locate AEDs in high employment areas of Philadelphia and characterize the process of door-to-door surveying to identify these devices.</AbstractText>Block groups representing appro... |
2,333,889 | Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. | Exposure to cyanide causes a spectrum of cardiac, neurological, and metabolic dysfunctions that can be fatal. Improved cyanide antidotes are needed, but the ideal biological pathways to target are not known. To understand better the metabolic effects of cyanide and to discover novel cyanide antidotes, we developed a ze... |
2,333,890 | Newly developed urinary retention and motor weakness of lower extremities in a postherpetic neuralgia patient. | During the early stage of postherpetic neuralgia, an epidural block on the affected segment is helpful in controlling pain and preventing progression to a chronic state. The main neurologic complication following an epidural block is cord compression symptom due to an epidural hematoma. When neurologic complications ar... |
2,333,891 | Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits. | Feeding a high-fat diet (HFD) to rabbits results in increased blood pressure and renal sympathetic nerve activity (RSNA) and marked increases in plasma leptin and insulin. We determined the contribution of insulin and leptin signaling in the central nervous system to the increased blood pressure and RSNA during a HFD u... |
2,333,892 | Psychometric testing of the Chinese Mandarin version of the Medical Outcomes Study Social Support Survey in patients with coronary heart disease in mainland China. | To evaluate the psychometric properties of the Chinese Mandarin version of the Medical Outcomes Study Social Support Survey (MOS-SSS-CM) in patients with coronary heart disease (CHD) in mainland China.</AbstractText>Measurement performance of the MOS-SSS-CM was tested on a convenience sample of 200 Chinese patients wit... |
2,333,893 | The association between leisure time physical activity and coronary heart disease among men with different physical work demands: a prospective cohort study. | The interplay of occupational and leisure time physical activity (LTPA) in affecting cardiovascular health is subject to debate. This study aimed to examine the independent and interacting associations of leisure time and occupational physical activity (OPA) with the incidence of coronary events within the BELSTRESS co... |
2,333,894 | Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. | Tolazoline is an α2-adrenergic receptor antagonist, used in veterinary medicine to antagonize the central nervous system depressant and cardiovascular effects of α2 receptor agonists. The pharmacokinetics and pharmacodynamic effects of tolazoline when administered subsequent to detomidine in the horse were ... |
2,333,895 | Conduction and block of inward rectifier K+ channels: predicted structure of a potent blocker of Kir2.1. | Dysfunction of Kir2.1, thought to be the major component of inward currents, I(K1), in the heart, has been linked to various channelopathies, such as short Q-T syndrome. Unfortunately, currently no known blockers of Kir2.x channels exist. In contrast, Kir1.1b, predominantly expressed in the kidney, is potently blocked ... |
2,333,896 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. | Individuals exposed to life-threatening trauma are at risk for developing post-traumatic stress disorder (PTSD), a debilitating condition that involves persistent anxiety, intrusive memories and several physiological disturbances. Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically h... |
2,333,897 | Cardiac arrest following spinal anaesthesia for caesarean section: a case report. | Spinal anaesthesia is regarded safe for caesarean section. Serious complications resulting from spinal anaesthesia such as cardiac arrest are often times considered rare. This is a case of a 27-year old unbooked gravida1 who was scheduled for emergency caesarean section on account of cephalo-pelvic disproportion (CPD) ... |
2,333,898 | Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats. | Electroacupuncture (EA) at P5-P6 acupoints overlying the median nerves typically reduces sympathoexcitatory blood pressure (BP) reflex responses in eucapnic rats. Gastric distention in hypercapnic acidotic rats, by activating both vagal and sympathetic afferents, decreases heart rate (HR) and BP through actions in the ... |
2,333,899 | In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. | Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury, a deficiency that underlies the poor regenerative ability of human hearts after myocardial infarction. By contrast, zebrafish regenerate heart muscle after trauma by inducing proliferation of spared cardiomyocytes, providing a mod... |
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