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2,334,000 | Comparison of three fluid regimens for preloading in elective caesarean section under spinal anaesthesia. | The most common problem associated with subarachnoid block (SAB) for caesarean section remains the rapid onset of profound hypotension. This study was designed to compare the incidence of hypotension after preloading with Ringer's Lactate, Hydroxyethylstarch and combination prior to SAB in caesarean section. Ninety non... |
2,334,001 | [Anti-Ro/SSA antibodies in congenital heart block]. | Describe a case of a female patient having anti-Ro/SSA antibodies without any other risk factor or collagen disease. In her first pregnancy a congenital heart block and hydrops in the fetus were diagnosed, and these caused stillbirth. In a second pregnancy an in utero treatment resulted in the succesful delivery of a n... |
2,334,002 | Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine. | Dexmedetomidine, an α(2)-receptor agonist, prolongs analgesia when used in neuraxial and IV blocks. We evaluated the effect of dexmedetomidine added to ropivacaine for tibial nerve block on the duration of the sensory blockade.</AbstractText>For this prospective, randomized, controlled, double-blind, crossover tr... |
2,334,003 | Suspected brainstem anesthesia following retrobulbar block in a cat. | A 10-year-old, male, neutered, domestic shorthair cat was anesthetised for enucleation of a perforated left globe. A retrobulbar injection of local anesthetic (lidocaine/bupivacaine) was performed prior to surgery to provide intra- and postoperative analgesia. Following administration of the injection, the cat develope... |
2,334,004 | Extracardiac minimal invasive implantation of cardioverter defibrillator in young children. | Implantable cardioverter defibrillator (ICD) placement in young children remains a challenge due to device-patient size mismatch and the important choice between an endovenous or an epicardial approach for lead implantation. We treated three children, with respectively Long QT-syndrome, Brugada syndrome and Brugada syn... |
2,334,005 | Fluid-dynamics modelling of the human left ventricle with dynamic mesh for normal and myocardial infarction: preliminary study. | Pulsating blood flow patterns in the left ventricular (LV) were computed for three normal subjects and three patients after myocardial infarction (MI). Cardiac magnetic resonance (MR) images were obtained, segmented and transformed into 25 frames of LV for a computational fluid dynamics (CFD) study. Multi-block structu... |
2,334,006 | A New Anterior Approach for Fluoroscopy-guided Suprascapular Nerve Block - A Preliminary Report -. | The aim of the study was to investigate the feasibility of fluoroscopy-guided anterior approach for suprascapular nerve block (SSNB).</AbstractText>Twenty patients with chronic shoulder pain were included in the study. All of the nerve blocks were performed with patients in a supine position. Fluoroscopy was tilted med... |
2,334,007 | A phenotype-genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom. | ADAMTS13 mutations play a role in thrombotic thrombocytopenic purpura (TTP) pathogenesis.</AbstractText>To establish a phenotype-genotype correlation in a cohort of congenital TTP patients.</AbstractText><AbstractText Label="PATIENTS/METHODS" NlmCategory="METHODS">Clinical history and ADAMTS13 activity, antigen and ant... |
2,334,008 | [Application of ultrasound guidance for ilioinguinal or iliohypogastric nerve block in pediatric inguinal surgery]. | To evaluate the efficacy of ultrasound guidance for ilioinguinal or iliohypogastric nerve block in pediatric outpatients undergoing inguinal surgery.</AbstractText>The present study was approved by the ethics committee of our hospital. One hundred children with ASA status I, aged 4 - 8 years old, scheduled for unilater... |
2,334,009 | Effect of magnesium sulfate pretreatment on onset and recovery characteristics of cisatracurium. | To determine how pretreatment with magnesium sulfate (MgSO(4)) potentiates neuromuscular blocking agents. We investigated how the onset and recovery characteristics of cisatracurium are changed by pretreatment with MgSO(4).</AbstractText>After Institutional Review Board approval, a total of 48 ASA I and II patients wer... |
2,334,010 | Assessing physician leadership styles: application of the situational leadership model to transitions in patient acuity. | The situational leadership model suggests that an effective leader adapts leadership style depending on the followers' level of competency.</AbstractText>We assessed the applicability and reliability of the situational leadership model when observing residents in simulated hospital floor-based scenarios.</AbstractText>... |
2,334,011 | [Role of autoimmune reactions in development of cardiac arrhythmia and conduction disturbances]. | Cardiac arrhythmias and conduction disturbances are an important cause of morbidity and mortality in many countries all over the world Etiology of these disorders remains unclear in many patients. Experimental and clinical studies show that autoimmune reactions may be involved in development of arrhythmias and cardiac ... |
2,334,012 | Intracardiac acoustic radiation force impulse imaging: a novel imaging method for intraprocedural evaluation of radiofrequency ablation lesions. | Arrhythmia recurrence after cardiac radiofrequency ablation (RFA) for atrial fibrillation has been linked to conduction through discontinuous lesion lines. Intraprocedural visualization and corrective ablation of lesion line discontinuities could decrease postprocedure atrial fibrillation recurrence. Intracardiac acous... |
2,334,013 | The predictive value of anti-SS-A antibodies titration in pregnant women with fetal congenital heart block. | Fetal congenital complete heart block (CHB) is irreversible and is associated with significant mortality and morbidity. Anti-SS-A antibodies in the maternal sera are involved in its pathogenesis; however, the predictive value of the antibody titer and its role in prediction of this complication are controversial. The a... |
2,334,014 | Immediate cardiac arrest after neostigmine administration. | Many drugs used in anaesthesia have some potential fatal consequences; for example complete heart block and Q-Tc interval prolongation. Since the parasympathetic system in children is not fully developed, electrical transmission of the heart is not stable. Neostigmine is used in order to reverse neuromuscular block but... |
2,334,015 | Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia. | The heart receives sympathetic and parasympathetic efferent innervation as well as the ability to process information internally via an intrinsic cardiac autonomic nervous system (ICANS). For over a century, the role of the parasympathetics via vagal acetylcholine release was related to controlling primarily heart rate... |
2,334,016 | New anticancer agents: hormones made within the heart. | The heart is a sophisticated endocrine gland synthesizing the atrial natriuretic peptide (ANP) prohormone which contains four peptide hormones, namely atrial natriuretic peptide, vessel dilator, kaliuretic peptide and long-acting natriuretic peptide, which decrease up to 97% of human pancreatic, breast, colon, prostate... |
2,334,017 | Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. | This study investigated the effects of antipsychotic drugs on heart function of gestational day (GD) 13 rat embryos in vitro since they all block the I(Kr)/hERG potassium ion channel in addition to their main pharmacological effect on neurotransmitters. The results showed that all the tested antipsychotic drugs caused ... |
2,334,018 | Clonidine as an adjuvant in axillary brachial plexus block for below elbow orthopedic surgeries: A comparison between local and systemic administration. | Axillary brachial plexus block for below elbow orthopedic surgery provides a safe and low-cost technique with the advantage of prolonged postoperative analgesia. Clonidine, with selective partial agonist activity on α2 adrenergic receptors, has significantly demonstrated its role in this regard as an adjuvant to ... |
2,334,019 | An intron-retaining splice variant of human cyclin A2, expressed in adult differentiated tissues, induces a G1/S cell cycle arrest in vitro. | Human cyclin A2 is a key regulator of S phase progression and entry into mitosis. Alternative splice variants of the G1 and mitotic cyclins have been shown to interfere with full-length cyclin functions to modulate cell cycle progression and are therefore likely to play a role in differentiation or oncogenesis. The alt... |
2,334,020 | Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. | Na(+)/K(+)-ATPase (NKA) is essential in regulating [Na(+)](i), and thus cardiac myocyte Ca(2+) and contractility via Na(+)/Ca(2+) exchange. Different NKA-α subunit isoforms are present in the heart and may differ functionally, depending on specific membrane localization. In smooth muscle and astrocytes, NKA-;... |
2,334,021 | [Basic mechanisms of the new antiarrhythmic drugs in atrial fibrillation]. | Atrial fibrillation (AF) is the most common sustained arrhythmia seen in clinical practice. Despite of new technological breakthroughs and the understanding of the mechanisms underlying AF, based on animal models and ablation procedures in patients, the antiarrhythmic drugs remain the main therapeutic strategy to resto... |
2,334,022 | Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. | Cardiac arrhythmias are initiated in regions that undergo cellular remodeling as a result of disease. Using a sub-cellular model of myocardium, we studied the mechanism of block caused by tissue microstructure remodeling: cell geometry [quantified as length/width (L/W) cell ratio] and cell-to-cell coupling (G(j)). Hete... |
2,334,023 | Using the negative exponential distribution to quantitatively review the evidence on how rapidly the excess risk of ischaemic heart disease declines following quitting smoking. | No previous review has formally modelled the decline in IHD risk following quitting smoking. From PubMed searches and other sources we identified 15 prospective and eight case-control studies that compared IHD risk in current smokers, never smokers, and quitters by time period of quit, some studies providing separate b... |
2,334,024 | Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. | Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown.</AbstractText>We determined the electrophysiological and pharmacological properties of Nav1.... |
2,334,025 | High-resolution 3-dimensional reconstruction of the infarct border zone: impact of structural remodeling on electrical activation. | Slow nonuniform electric propagation in the border zone (BZ) of a healed myocardial infarct (MI) can give rise to reentrant arrhythmia. The extent to which this is influenced by structural rather than cellular electric remodeling is unclear.</AbstractText>To determine whether structural remodeling alone in the infarct ... |
2,334,026 | Targeted therapies in breast cancer: are heart and vessels also being targeted? | The concept of 'targeted' therapies implies that such drugs only act on cells that specifically express the particular target, therefore giving rise to a low incidence of side effects. However, targeted therapies currently approved for the treatment of breast cancer have demonstrated a relatively high incidence of card... |
2,334,027 | Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans.<Pagination><StartPage>H457</StartPage><EndPage>H463</EndPage><MedlinePgn>H457-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/ajpheart.00236.2012</ELocationID><Abstract><AbstractText>We have ... | We have recently shown that a saline infusion in the veins of an arterially occluded human forearm evokes a systemic response with increases in muscle sympathetic nerve activity (MSNA) and blood pressure. In this report, we examined whether this response was a reflex that was due to venous distension. Blood pressure (F... |
2,334,028 | Comparison of three different formulations of local anaesthetics for cervical epidural anaesthesia during thyroid surgery. | To compare the efficacy and safety of local anaesthetics under cervical epidural anaesthesia (CEA) using lignocaine (1%), bupivacaine (0.25%) and ropivacaine (0.5%) for thyroid surgery.</AbstractText>In a prospective, randomized fashion, 81 patients were selected for thyroid surgery under CEA. They were assigned to one... |
2,334,029 | Mistaken identity: severe vomiting, bradycardia and hypotension after eating a wild herb. | A 53-year-old woman presented with severe vomiting 3.5 hours after eating a boiled wild herb thought to be Hosta montana. She was alert, and did not complain of diplopia or numbness of her limbs. Her vital signs were temperature of 35.9°C, blood pressure of 84/33 mmHg, and heart rate of 59 beats/minute. There was ... |
2,334,030 | A case of Rosai-Dorfman disease in a pediatric patient with cardiac involvement. | Rosai-Dorfman disease (RDD) involves abnormal proliferations of oddly behaving histocytes that are not derived from the Langerhan's Cell linage. These collections tend to occur within lymph nodes, with occasional extra nodal presentation. While RDD is a rare entity itself, extra nodal cases are even more so, with even ... |
2,334,031 | Amnesia and pain relief after cardiopulmonary resuscitation in a cancer pain patient: a case report. | The mechanism of chronic pain is very complicated. Memory, pain, and opioid dependence appear to share common mechanism, including synaptic plasticity, and anatomical structures. A 48-yr-old woman with severe pain caused by bone metastasis of breast cancer received epidural block. After local anesthetics were injected,... |
2,334,032 | Cerebellar Purkinje cell neurodegeneration after cardiac arrest: effect of therapeutic hypothermia. | The cerebellum is among the brain regions most vulnerable to damage caused by cardiac arrest, and cerebellar Purkinje cell loss may contribute to neurologic dysfunction, including post-hypoxic myoclonus. However, it remains unknown whether cerebellar Purkinje cells are protected by post-cardiac arrest therapeutic hypot... |
2,334,033 | Cardiac conduction block at multiple levels caused by arsenic trioxide therapy. | We present a rare case of a woman aged 62 years with refractory acute promyelocytic leukemia treated with arsenic trioxide leading to progressive, multilevel cardiac conduction block. After chelation treatment with dimercaprol, there was normalization of conduction. |
2,334,034 | Management of central venous gradient using excimer laser lead extraction of chronic indwelling pacemaker leads in the setting of ipsilateral arteriovenous fistula. | Device therapy is becoming common in those patients with renal insufficiency. Coexisting need for arteriovenous (AV) fistula placement is often contemplated relative to device placement. We describe the excimer laser lead extraction of a malfunctioning chronic atrial pacemaker lead ipsilateral to an AV fistula. |
2,334,035 | Effect of dietary inulin and phytase on mineral digestibility and tissue retention in weanling and growing swine. | The effect of dietary phytase and the prebiotic inulin on apparent mineral digestibility, bone mineralization, and tissue mineral contents was evaluated in weanling and growing pigs. In Exp. 1, inulin and phytase were incorporated in a 2 × 3 factorial arrangement of treatments with 8 replicate pens per treatment i... |
2,334,036 | Evaluation of peri-operative epidural analgesia with ropivacaine, ropivacaine and sufentanil, and ropivacaine, sufentanil and epinephrine in isoflurane anesthetized dogs undergoing tibial plateau levelling osteotomy. | The purpose of this study was to compare four epidural protocols for peri-operative analgesia in dogs undergoing tibial plateau levelling osteotomy. Forty client-owned dogs were randomly assigned to one of four treatments - groups R0.5 and R1 received 0.5mg/kg and 1mg/kg ropivacaine, respectively. Group SR0.5 received ... |
2,334,037 | Octreotide-induced asystolic events in an intensive care unit patient with gastrointestinal bleeding. | Octreotide is a somatostatin analogue used to control upper gastrointestinal bleeding. We report a case of a patient with no significant cardiac history who had multiple asystolic events during an octreotide infusion at a relatively low dose. Although octreotide leading to bradycardia and heart block has been documente... |
2,334,038 | SU-E-J-44: Dual Energy Subtraction Imaging to Improve Tumor Visibility at Oblique Angles. | To characterize the contrast improvement of simulated tumors in an anthropomorphic phantom using Dual Energy (DE) subtraction with a clinical on-board imager (OBI) at oblique angles.</AbstractText>An Alderson lung/chest anthropomorphic phantom with simulated tumors in the thoracic cavity was imaged using a sequential D... |
2,334,039 | SU-E-T-276: Treatment Planning Strategies for Lung Injury Studies in Rat Models in 6 MV Delivery. | To study planning strategies that can be used in small animal radiation-induced lung toxicity experiments using 6 MV accelerator with high density MLC.</AbstractText>Three different types of plans were designed on CT images of a Sprague Dawley rat model to irradiate 50% of the total lung volume (lung divided into apex ... |
2,334,040 | Effects of adding dexmedetomidine to levobupivacaine in axillary brachial plexus block. | Although several studies have described effects of dexmedetomidine on peripheral nerve blocks, to date there is limited knowledge available on the impact of dexmedetomidine adjunct to levobupivacaine in axillary brachial plexus block.</AbstractText>In this study, we aimed to investigate the effects of adding dexmedetom... |
2,334,041 | Does epidural clonidine improve postoperative analgesia in major vascular surgery? | To determine the quality and duration of the analgesic and haemodynamic effects of clonidine when used as an additional analgesic for postoperative epidural analgesia in major vascular surgery.</AbstractText>The prospective, single-blinded study involved 60 patients randomised into three groups (20 patients each): Grou... |
2,334,042 | Natural history of conduction abnormalities in a patient with Kearns-Sayre syndrome. | Kearns-Sayre syndrome is a rare mitochondrial disorder characterized by large-scale deletion or rearrangement of mitochondrial DNA, which is usually not inherited but occur spontaneously probably at the germ cell level or very early in embryonic development by Mehndiratta et al. (Neurol India 50:162-167, 2002). Neuromu... |
2,334,043 | Influence of starter protein content on growth of dairy calves in an enhanced early nutrition program. | Our objectives were to determine the effect of starter crude protein (CP) content on growth of Holstein calves from birth to 10 wk of age in an enhanced early nutrition program, and to compare the enhanced program to a conventional milk replacer program. Calves (64 female, 25 male) were assigned to 3 treatments in a ra... |
2,334,044 | Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events. | Nonalcoholic steatohepatitis (NASH) is an independent predictor of coronary artery disease (CAD). Our aim was to compare the incidence of cardiovascular (CV) events between patients transplanted for NASH and alcohol (ETOH)-induced cirrhosis. This is a retrospective cohort study (August 1993 to March 2010) of 242 patien... |
2,334,045 | Cardioprotection from oxidative stress in the newborn heart by activation of PPARγ is mediated by catalase. | Regulation of catalase (CAT) by peroxisome proliferator-activated receptor-γ (PPARγ) was investigated to determine if PPARγ activation provides cardioprotection from oxidative stress caused by hydrogen peroxide (H(2)O(2)) in an age-dependent manner. Left ventricular developed pressure (LVDP) was measu... |
2,334,046 | Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings. | M-channels carry slowly activating potassium currents that regulate excitability in a variety of central and peripheral neurons. Functional M-channels and their Kv7 channel correlates are expressed throughout the somatosensory nervous system where they may play an important role in controlling sensory nerve activity. H... |
2,334,047 | PKCβII modulation of myocyte contractile performance. | Significant up-regulation of the protein kinase Cβ(II) (PKCβ(II)) develops during heart failure and yet divergent functional outcomes are reported in animal models. The goal here is to investigate PKCβ(II) modulation of contractile function and gain insights into downstream targets in adult cardiac my... |
2,334,048 | Improved outcomes in paediatric anaesthesia: contributing factors. | To discuss developments in paediatric anaesthesia and explore the factors which have contributed to improved anaesthetic-related patient outcomes.</AbstractText>Narrative review of findings in the literature retrieved from MEDLINE/Pubmed and manual search.</AbstractText>Adverse perioperative outcomes related to anaesth... |
2,334,049 | Isolated left-ventricular apical hypoplasia presenting as a left-ventricular mass on echocardiography. | Left-ventricular apical hypoplasia is a rare entity. Although it has typical imaging features on cardiovascular magnetic resonance, recognizing this condition on echocardiography can be challenging. This report describes an asymptomatic pediatric patient who initially presented with a left-ventricular mass on echocardi... |
2,334,050 | How reading in a second language protects your heart. | Reading words in a second language spontaneously activates native language translations in the human bilingual mind. Here, we show that the emotional valence of a word presented in English constrains unconscious access to its Chinese translation. We asked native speakers of Chinese fluent with English to indicate wheth... |
2,334,051 | Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action. | Na(V)1.5 is a mechanosensitive voltage-gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties.</AbstractText>Mechanosensitivity of Na(V)1.5 was tested in ... |
2,334,052 | Symptomatic epidural gas cyst treated with epidural block and percutaneous needle aspiration -A case report-. | A 68-year-old woman suffered from lower back and radiating pain on her right buttock and posterior calf. Axial magnetic resonance imaging showed a 7 × 7 mm nodular lesion (T1 and, T2 low signal intensity) at the epidural space between the L5-S1 level and computed tomography revealed it was an epidural gas cyst. Th... |
2,334,053 | Regional cardiac motion and strain estimation in three-dimensional echocardiography: a validation study in thick-walled univentricular phantoms. | Automatic quantification of regional left ventricular deformation in volumetric ultrasound data remains challenging. Many methods have been proposed to extract myocardial motion, including techniques using block matching, phase-based correlation, differential optical flow methods, and image registration. Our lab previo... |
2,334,054 | [Pulmonary hypertension and femoral neck fracture: interest of continuous spinal anaesthesia]. | Anaesthetic management of patients with pulmonary hypertension is challenging and alternatives to general anaesthesia are encouraged. We report anaesthetic management of two patients with pulmonary hypertension admitted for femoral neck fracture. In order to reduce the risk of right-sided heart failure and systemic hyp... |
2,334,055 | Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation. | Pre-menopausal females have a lower incidence of cardiovascular disease compared with age-matched males, implying differences in the mechanisms and pathways regulating vasoactivity. In small arteries, myogenic tone (constriction in response to raised intraluminal pressure) is a major determinant of vascular resistance.... |
2,334,056 | Overexpression of Shp-2 attenuates apoptosis in neonatal rat cardiac myocytes through the ERK pathway. | During cardiac ischemia and end-stage heart disease, a large number of cardiac cells are apoptotic, and therefore, heart function is impaired. Although the role of Shp-2 in cell survival has been reported, its regulation of cardiac apoptosis is still undetermined. To better understand the potential role of Shp-2 in apo... |
2,334,057 | Intracellular spatial localization regulated by the microtubule network. | The commonly recognized mechanisms for spatial regulation inside the cell are membrane-bounded compartmentalization and biochemical association with subcellular organelles. We use computational modeling to investigate another spatial regulation mechanism mediated by the microtubule network in the cell. Our results demo... |
2,334,058 | Comparative evaluation of ropivacaine and lignocaine with ropivacaine, lignocaine and clonidine combination during peribulbar anaesthesia for phacoemulsification cataract surgery. | Peribulbar block is the most common type of local anaesthesia administered for cataract surgery, and continuous efforts are on to find a long-acting local anaesthetic (LA) drug with the safest pharmacological profile.</AbstractText>A double-blind, prospective and randomized study was carried out in our institute to com... |
2,334,059 | Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro. | This study investigated the effects of a range of antidepressant drugs on the heart of gestation day 13 rat embryos in vitro. The general hypothesis was that the drugs would adversely affect the function of the embryonic heart since they all have some cardiac ion channel blocking activity in addition to their main phar... |
2,334,060 | Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo. | Spermidine and spermine, are endogenous polyamines (PAs) that regulate cell growth and modulate the activity of numerous ion channel proteins. In particular, intracellular PAs are potent blockers of many different cation channels and are responsible for strong suppression of outward K (+) current, a phenomenon known as... |
2,334,061 | The effectiveness of physical activity interventions in socio-economically disadvantaged communities: a systematic review. | Interventions to increase levels of physical activity (PA) in socio-economically disadvantaged communities are needed but little is known about their effectiveness. This review examines the effectiveness of interventions designed to increase PA in these communities and the theoretical frameworks and components used.</A... |
2,334,062 | Persistence of perinatal mortality due to congenital malformations in resource-poor settings. | Every year, half a million babies are born with malformations, one-third of these life-threatening. The present study aims at analysing trends of perinatal mortality (PM) due to major congenital malformations (MCM) at a rural institute, for preventive possibilities. Records of all perinatal deaths due to MCM over 24 ye... |
2,334,063 | Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. | Spatial heterogeneity in connexin (Cx) expression has been implicated in arrhythmogenesis.</AbstractText>This study was performed to quantify the relation between the degree of heterogeneity in Cx43 expression and disturbances in electric propagation.</AbstractText>Cell pairs and strands composed of mixtures of Cx43(-/... |
2,334,064 | An epidemiologic transition of cardiovascular disease risk in Carriacou and Petite Martinique, Grenada: the Grenada Heart Project, 2005-2007. | The epidemiologic transition has made chronic disease a major health threat in the Caribbean and throughout the world. Our objective was to examine the pattern of lifestyle factors associated with cardiovascular disease (CVD) in Grenada and to determine whether the prevalence of CVD risk factors differs by subgroups.</... |
2,334,065 | Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus. | Maternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lupus (cardiac NL), yet only 2% of women with this reactivity have an affected child. Identification of a more specific marker would channel intense monitoring to fetuses at greater risk. This study aimed to determine whether autoant... |
2,334,066 | Comparison of the anaesthetic efficacy of and heart rate changes after periodontal ligament or intraosseous X-Tip injection in mandibular molars: a randomized controlled clinical trial. | To compare the efficacy of supplemental anaesthesia using periodontal ligament injections (PDL) and intraosseous injections with the X-Tip system in terms of the measured heart rate and patient reported pain level.</AbstractText>In this single-blind randomized clinical trial, 40 patients (22 women, 18 men) with irrever... |
2,334,067 | Selective block of K(ATP) channels: why the anti-diabetic sulphonylureas and rosiglitazone have more in common than we thought. | Rosiglitazone, the thiazolidinedione class anti-diabetic withdrawn from Europe in 2010 amid reports of adverse cardiovascular effects, is revealed by Yu et al. in this issue of the British Journal of Pharmacology to be a selective blocker of ATP-sensitive potassium (K(ATP) ) channels. This seems little cause for excite... |
2,334,068 | 2D myocardial strain assessment in the mouse: a comparison between a synthetic lateral phase approach and block-matching using computer simulation. | Estimating myocardial strain in the mouse with clinical equipment remains difficult due to the high heart rate and the small size of the mouse heart. Measuring the strain component perpendicular to the ultrasound beam is especially challenging because of the lack of phase information in that direction and the large spe... |
2,334,069 | Blocked muscle fat oxidation during exercise in neutral lipid storage disease.<Pagination><StartPage>530</StartPage><EndPage>533</EndPage><MedlinePgn>530-3</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/archneurol.2011.631</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJE... | Certain species of urodeles and teleost fish can regenerate their tissues. Zebrafish have become a widely used model to study the spontaneous regeneration of adult tissues, such as the heart, retina, spinal cord, optic nerve, sensory hair cells, and fins. The zebrafish fin is a relatively simple appendage that is easil... |
2,334,070 | Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation. | The administration of certain sedatives has been shown to promote sleep in humans. Related agents induce sleep-like behavior when administered to horses. Interpretation of electroencephalograms (EEGs) obtained from sedated horses should take into account background activity, presence of sleep-related EEG events, and th... |
2,334,071 | The effect of intravenous morphine on the level of spinal anesthesia with lidocaine. | One of the major concerns in spinal anesthesia with lidocaine is its short duration of action. Enhancement is necessary in some situations during surgery, because surgeons encounter with unexpected events and need more time. Therefore there is a need to increase anesthesia duration in these situations. Many studies inv... |
2,334,072 | Reduced models for unidirectional block conduction and their geometrical setting. | This article revisits a reduced model of cardiac electro-physiology which was proposed to understand the genesis of unidirectional block pathology and of ectopic foci. We underline some specificities of the model from the viewpoint of dynamical systems and bifurcation theory. We point out that essentially the same prop... |
2,334,073 | Cultural challenges to secondary prevention: implications for Saudi women. | Like other highly developed countries, cardiovascular disease (CVD) and coronary heart disease (CHD) are major health problems in Saudi Arabia. The aetiology of cardiovascular disease (CVD) burden within the Saudi population is similar to Western countries with atherosclerosis, hypertension, ischemic heart disease and ... |
2,334,074 | The effect of poloxamer 407 on the functional properties of HDL in mice. | There is an inverse relationship between high-density lipoprotein (HDL) and heart disease. HDL possesses not only both antioxidant and anti-inflammatory properties, but also anti-thrombotic and endothelial function-promoting qualities. However, it is not only the serum concentration of HDL that is important, but also t... |
2,334,075 | Pedestrian accident analysis with a silicone dummy block. | When a car is parked in an inclined plane in a parking lot, the car can roll down the slope and cause a pedestrian accident, even when the angle of inclination is small. A rolling car on a gentle slope seems to be easily halted by human power to prevent damage to the car or a possible accident. However, even if the car... |
2,334,076 | Time-based compression and classification of heartbeats. | Heart function measured by electrocardiograms (ECG) is crucial for patient care. ECG generated waveforms are used to find patterns of irregularities in cardiac cycles in patients. In many cases, irregularities evolve over an extended period of time that requires continuous monitoring. However, this requires wireless EC... |
2,334,077 | Combining psychosocial data to improve prediction of cardiovascular disease risk factors and events: The National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome Evaluation study. | There is overlap among psychosocial predictors of cardiovascular disease (CVD). The usefulness of combining psychosocial variables as risk markers for CVD needs investigation.</AbstractText>Participants were 493 women in the NHLBI WISE study. Multivariate combination of Beck Depression Inventory (BDI), State-Trait Anxi... |
2,334,078 | Effects of intrathecally administered fentanyl on duration of analgesia in patients undergoing spinal anaesthesia for elective caesarean section. | Intrathecal opioids have gained popularity in obstetrics; they augment the analgesia produced by local anaesthetic agents. The aim of this study is to determine the duration of analgesia following addition of fentanyl to bupivacaine during elective Caesarean section.</AbstractText>This is a prospective randomized study... |
2,334,079 | Sick sinus syndrome and orthostatic hypotension in Parkinson's disease. | We present a case of Parkinson's disease patient whose initial symptoms were sick sinus syndrome and orthostatic hypotension. Our case illustrates difficulties in distinguishing syncope of primary cardiac or neurological origin and highlights the importance of a diagnostic workup including neurological examination. |
2,334,080 | Cyclosporine treatment improves cardiac function and systemic hemodynamics during resuscitation in a newborn piglet model of asphyxia: a dose-response study. | Asphyxiated neonates often have myocardial depression, which is a significant cause of morbidity and mortality. Cardioprotective effects of cyclosporine have been observed in adult patients and animals with myocardial infarction. However, the cardioprotective effect of cyclosporine in neonates has not yet been studied.... |
2,334,081 | Myotonic Dystrophy Type 1 or Steinert's disease. | Myotonic Dystrophy Type 1 (DM1) is the most common worldwide autosomal dominant muscular dystrophy due to polynucleotide [CTG]( n ) triplet expansion located on the 3'UTR of chromosome 19q13.3. A toxic gain-of-function of abnormally stored RNA in the nuclei of affected cells is assumed to be responsible for several cli... |
2,334,082 | Thoracic epidural analgesia via the lumbosacral approach using multiport catheters with a low concentration of bupivacaine and morphine in sheep. | To determine the analgesic and systemic effects of thoracic epidural administration of bupivacaine (BP) and morphine (MP) in conscious sheep.</AbstractText>Randomized, crossover, experimental study.</AbstractText>Six healthy castrated sheep weighing between 40 and 50 kg.</AbstractText>Each sheep received, via the lumbo... |
2,334,083 | Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial. | By contrast with many observational studies, women in the Women's Health Initiative (WHI) trial who were randomly allocated to receive oestrogen alone had a lower incidence of invasive breast cancer than did those who received placebo. We aimed to assess the influence of oestrogen use on longer term breast cancer incid... |
2,334,084 | Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. | Drosophila is a useful model organism in which the genetics of human diseases, including recent advances in identification of the genetics of heart development and disease in the fly, can be studied. To identify novel genes that cause cardiomyopathy, we performed a deficiency screen in adult Drosophila. Using optical c... |
2,334,085 | Community based needs assessment in an urban area: a participatory action research project. | Community assessment is a core function of public health. In such assessments, a commitment to community participation and empowerment is at the heart of the WHO European Healthy Cities Network, reflecting its origins in health for all and the Ottawa Charter for Health Promotion. This study employs a participation and ... |
2,334,086 | In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarials. | The in vitro cardiac properties of dihydroartemisinin (DHA) plus piperaquine phosphate (PQP) were compared with those of other antimalarial compounds. Results with antimalarial drugs, chosen on the basis of their free therapeutic maximum concentration in plasma (C(max)), were expressed as the fold of that particular ef... |
2,334,087 | Pediatric flecainide toxicity from a double dose. | A 23-month-old boy was brought to the emergency department of an adult and pediatric tertiary care center 1 hour after an inadvertent “double dose” of 120 mg flecainide (9.2 mg/kg). His electrocardiogram revealed sinus rhythm with a terminal R wave in aVR greater than 7 mm, a bifascicular block, and prolo... |
2,334,088 | Histopathologic characterization of chronic radiofrequency ablation lesions for pulmonary vein isolation.<Pagination><StartPage>930</StartPage><EndPage>938</EndPage><MedlinePgn>930-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jacc.2011.09.076</ELocationID><Abstract><AbstractText Label="OB... | Aim of the study is to compare efficiency and safety of method of spinal anesthesia with isobaric bypivacain (5 mg/ml) and ropivacain 5 (mg/ml) during performing transurethral resection of the prostate in patients over 60 years old. Methods 38 patients (68-82 years old ASAII-ASAIII) with hyperplasia of prostate gland w... |
2,334,089 | Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep. | To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep.</AbstractText>Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural i... |
2,334,090 | Adverse cardiovascular effects of antirheumatic drugs: implications for clinical practice and research. | Clinical manifestations of most rheumatic diseases have changed over the past few decades, largely due to advances in therapies targeting autoimmune and (auto)inflammatory pathways. Improvements in the management of rheumatic diseases have also now brought to the fore the issue of comorbidities. It has become evident t... |
2,334,091 | Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. | Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arrhythmic ability is lacking. Under standardized conditions, we... |
2,334,092 | A comparison of the effectiveness of predictors of caudal block in children-swoosh test, anal sphincter tone, and heart rate response. | To study the effectiveness of three predictors of successful caudal block in children, viz. swoosh test, heart rate response to injection, and laxity of anal sphincter tone.</AbstractText>To improve the success rates of caudal block in children by identifying the best predictor.</AbstractText>Caudal blocks in children ... |
2,334,093 | Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels. | Many studies have indicated that hyperpolarizing cardioplegia is responsible for myocardial preservation and researchers have suggested that the adenosine triphosphate-sensitive potassium channels (K(ATP)) were the end effectors of cardio-protection. But whether mitochondrial K(ATP) plays an important role in hyperpola... |
2,334,094 | [The in-hospital mortality and its determinants for very elderly patients with acute myocardial infarction]. | To explore the in-hospital mortality and its determinants for very eldly (80+ years of age) patients with acute myocardial infarction (AMI).</AbstractText>A retrospective cohort method was used. The 499 study subjects were very eldly patients with newly diagnosed AMI consecutively admitted into our department between J... |
2,334,095 | Correlates of global area strain in native hypertensive patients: a three-dimensional speckle-tracking echocardiography study. | The present study aimed to test the capability of real-time three-dimensional echocardiography (RT3DE) in characterizing early abnormalities of left ventricular (LV) structure and function in native, untreated hypertensive patients.</AbstractText>Thirty-eight newly diagnosed, never-treated hypertensives (H) and 38 heal... |
2,334,096 | Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. | The intracellular trafficking of connexin 43 (Cx43) hemichannels presents opportunities to regulate cardiomyocyte gap junction coupling. Although it is known that Cx43 hemichannels are transported along microtubules to the plasma membrane, the role of actin in Cx43 forward trafficking is unknown.</AbstractText>We explo... |
2,334,097 | On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor. | The inhibition of adenosine deaminase with erythro-9 (2-hydroxy-3-nonyl)-adenine (EHNA) and the es-ENT1 transporter with p-nitro-benzylthioinosine (NBMPR), entraps myocardial intracellular adenosine during on-pump warm aortic crossclamping, leading to a complete recovery of cardiac function and adenosine triphosphate (... |
2,334,098 | Effect of warmed ropivacaine solution on onset and duration of axillary block. | Bicarbonate, as an adjunct increasing the non-ionized form of local anesthetics, can reduce latency and prolong duration of regional nerve block. Warming of local anesthetics decreases pKa and also increases the non-ionized form of local anesthetics. We warmed ropivacaine to body temperature (37℃) and evaluated ... |
2,334,099 | Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial. | Preclinical research implicates dopaminergic and noradrenergic mechanisms in mediating the reinforcing effects of drugs of abuse, including cocaine. The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positive subjective effects of c... |
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