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2,334,100 | Second malignant neoplasms and cardiovascular disease following radiotherapy. | Second malignant neoplasms (SMNs) and cardiovascular disease (CVD) are among the most serious and life-threatening late adverse effects experienced by the growing number of cancer survivors worldwide and are due in part to radiotherapy. The National Council on Radiation Protection and Measurements (NCRP) convened an ex... |
2,334,101 | Clonidine does not improve quality of ropivacaine axillary brachial plexus block in children. | The addition of clonidine to peripheral nerve blocks is controversial in children.</AbstractText>The aim of our study was to evaluate the effect of clonidine added to ropivacaine in pediatric axillary brachial plexus block (ABPB).</AbstractText>Children aged 1-6 years, scheduled to undergo forearm or hand surgery, were... |
2,334,102 | Prognostic values of clockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects: a 24-year follow-up of the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80). | Although clockwise rotation and counterclockwise rotation are distinct findings of the ECG, their prognostic significance is rarely studied.</AbstractText>We studied prognostic values of clockwise and counterclockwise rotation on total, cardiovascular disease (CVD), and subtype mortality using the National Integrated P... |
2,334,103 | Dynamic variations of P-wave duration in a patient with acute decompensated congestive heart failure. | Interatrial block is an abnormally delayed atrial activation, characterized at ECG by prolonged P-wave duration (more than 110 ms), irrespective of morphology. We report the case of a patient with acute decompensated severe congestive heart failure, that at hospital admission showed a prolonged P-wave, which reverted a... |
2,334,104 | Pros and cons for C4d as a biomarker. | The introduction of C4d in daily clinical practice in the late nineties aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. As a marker of classical complement activation, C4d made it possible to visualize the direct link between anti-donor antibodies and tissue injur... |
2,334,105 | Curvature-Dependent Excitation Propagation in Cultured Cardiac Tissue. | The geometry of excitation wave front may play an important role on the propagation block and spiral wave formation. The wave front which is bent over the critical value due to interaction with the obstacles may partially cease to propagate and appearing wave breaks evolve into rotating waves or reentry. This scenario ... |
2,334,106 | Medical therapy is best for atherosclerotic renal artery stenosis: Arguments for. | Atherosclerotic renal artery stenosis (ARAS) is a common condition that causes hypertension and reduction in the glomerular filtration rate and is an independent risk factor for death. Despite high technical success, the clinical benefit of renal artery (RA) angioplasty with stenting in ARAS remains doubtful. The publi... |
2,334,107 | Penile block for paediatric urological surgery: A comparative evaluation with general anaesthesia. | Peri-operative pain relief in children can be provided by conventional general anaesthesia or by regional nerve blocks. The present study was carried out to evaluate and compare the effectiveness of penile block for penile surgery with the standard technique of general anaesthesia (GA) of short duration of less than tw... |
2,334,108 | Associations of processed meat and unprocessed red meat intake with incident diabetes: the Strong Heart Family Study. | Fifty percent of American Indians (AIs) develop diabetes by age 55 y. Whether processed meat is associated with the risk of diabetes in AIs, a rural population with a high intake of processed meat (eg, canned meats in general, referred to as "spam") and a high rate of diabetes, is unknown.</AbstractText>We examined the... |
2,334,109 | [Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. | Myasthenia gravis is an autoimmune disease marked by high titers of immunoglobulin G antibodies, which accelerate destruction of cholinergic receptors and interfere with neuromuscular transmission. This study aimed to determine whether neuromuscular function under a rocuronium block is different from function under a v... |
2,334,110 | Venous flow dynamics during spinal block in normotensive and hypertensive elderly patients: a duplex ultrasonographic study. | Spinal block induces hyperkinetic change in lower extremity blood flow. We compared the venous flow dynamic responses to spinal block in normotensive and hypertensive elderly patients.</AbstractText>Following spinal block using 10 mg 0.5% (w/v) bupivacaine, we measured changes in blood pressure, heart rate, and ... |
2,334,111 | Block based neural network for hypoglycemia detection. | In this paper, evolvable block based neural network (BBNN) is presented for detection of hypoglycemia episodes. The structure of BBNN consists of a two-dimensional (2D) array of fundamental blocks with four variable input-output nodes and weight connections. Depending on the structure settings, each block can have one ... |
2,334,112 | HRV analysis in local anesthesia using Continuous Wavelet Transform (CWT). | Spectral analysis of Heart Rate Variability (HRV) is used for the assessment of cardiovascular autonomic control. In this study Continuous Wavelet Transform (CWT) has been used to evaluate the effect of local anesthesia on HRV parameters in a group of fourteen patients undergoing axillary brachial plexus block. A new m... |
2,334,113 | Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation. | Cardiac fibrosis is an important form of pathological tissue remodeling. Fibrosis can electrically-uncouple neighboring excitable cardiomyocytes thus acting as an obstacle to electrical propagation. In this study, we investigated the effects of fibrosis spatial pattern on electrical propagation in control, decreased ma... |
2,334,114 | Study of neurovascular and autonomic response in a divided attention test by means of EEG, ECG and NIRS signals. | We evaluated neurovascular and autonomic response to a Divided Attention task within a group of 16 healthy subjects, by means of Electroencephalography, Electrocardiography, functional Near Infrared Spectroscopy techniques, acquired simultaneously. We exctracted Alpha (8-13,5 Hz) and Beta (13,5-30 Hz) power rhythms wit... |
2,334,115 | Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities. | <AbstractText Label="AIMS/HYPOTHESIS" NlmCategory="OBJECTIVE">Patients with severe gain-of-function mutations in the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, have neonatal diabetes, muscle hypotonia and mental and motor developmental delay-a condition known as iDEND syndrome. However, despite the... |
2,334,116 | Anesthetic and analgesic effects in patients undergoing a lumbar laminectomy of spinal, epidural or a combined spinal-epidural block with the addition of morphine. | This study was designed to evaluate the anesthetic, analgesic and side effects of spinal, epidural and combined spinal-epidural anesthesia with the addition of morphine for lumbar laminectomy. A total of 66 patients undergoing lumbar laminectomy were included in the present study of whom 64 completed the study. Patient... |
2,334,117 | Comparing caudal and penile nerve blockade using bupivacaine in hypospadias repair surgeries in children. | Caudal anaesthesia is recommended for most surgical procedures of the lower part of the body, mainly below the umbilicus. It has been well established that a dorsal penile nerve block immediately after surgery decreases postoperative pain in children undergoing hypospadias repair. This study aimed to compare caudal or ... |
2,334,118 | Control of pain through epidural block and incidence of cardiac dysrhythmias in postoperative period of thoracic and major abdominal surgical procedures: a comparative study. | Upper abdomen and thorax surgeries cause intense pain. Some of postoperative pain main complications are cardiocirculatory complications. The objective of this study was to test the hypothesis that postoperative analgesia with employment of local anesthetics plus spinal opioids may reduce the incidence of cardiovascula... |
2,334,119 | The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles. | A new series of acid- and urea-functionalized polycarbonate block copolymers were synthesized via organocatalytic living ring-opening polymerization using methoxy poly(ethylene glycol) (PEG) as a macroinitiator to form micelles as drug delivery carriers. The micelles were characterized for critical micelle concentratio... |
2,334,120 | Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome. | It is well known that familial sick sinus syndrome (SSS) is caused by functional alterations of ion channels and gap junction. Limited information is available on the mechanism of age-related non-familial SSS. Although evidence shows a close link between arrhythmia and the renin-angiotensin system (RAS), it remains to ... |
2,334,121 | Impact of collection and storage of lung tumor tissue on whole genome expression profiling. | Gene expression profiling could assist in revealing biomarkers of lung cancer prognosis and progression. The handling of biological samples may strongly influence global gene expression, a fact that has not been addressed in many studies. We sought to investigate the changes in gene expression that may occur as a resul... |
2,334,122 | Structural studies on bovine heart cytochrome c oxidase. | Among the X-ray structures of bovine heart cytochrome c oxidase (CcO), reported thus far, the highest resolution is 1.8Å. CcO includes 13 different protein subunits, 7 species of phospholipids, 7 species of triglycerides, 4 redox-active metal sites (Cu(A), heme a (Fe(a)), Cu(B), heme a(3) (Fe(a3))) and 3 redox-ina... |
2,334,123 | cAMP and Epac in the regulation of tissue fibrosis. | Fibrosis, the result of excess deposition of extracellular matrix (ECM), in particular collagen, leads to scarring and loss of function in tissues that include the heart, lung, kidney and liver. The second messenger cAMP can inhibit the formation and extent of ECM during this late phase of inflammation, but the mechani... |
2,334,124 | Escape-echo bigeminy. | Escape-capture bigeminy is a well-known arrhythmia characterized by group beating of a junctional beat followed by a conducted sinus beat. We report a variant of this arrangement where a junctional beat gives rise to a retrograde P wave, which is then conducted back to the ventricles producing a hitherto undescribed co... |
2,334,125 | Modelling tissue electrophysiology with multiple cell types: applications of the extended bidomain framework. | The bidomain framework has been extensively used to model tissue electrophysiology in a variety of applications. One limitation of the bidomain model is that it describes the activity of only one cell type interacting with the extracellular space. If more than one cell type contributes to the tissue electrophysiology, ... |
2,334,126 | A Comparison between Sedative Effect of Propofol-Fentanyl and Propofol-Midazolam Combinations in Microlaryngeal Surgeries. | Considering the growing trend of laryngeal surgeries and the need to protect the airway during and after surgery, among several therapeutic regimens to induce sedation, two regimens of propofol-fentanyl and propofol-midazolam were compared in microlaryngeal surgeries. Forty ASA I-II class patients undergoing microlaryn... |
2,334,127 | The effects of vibration during maximal graded cycling exercise: a pilot study. | Whole Body Vibration training is studied and used in different areas, related to sport performance and rehabilitation. However, few studies have investigated the effects of Vibration (Vib) exposure on aerobic performance through the application of this concept to cycling exercise. A specifically designed vibrating cycl... |
2,334,128 | Congenital complete heart block in a 71-year old. | A case of a 71-year-old male with congenital complete heart block is discussed. Patient remained asymptomatic with stable electrocardiograms. |
2,334,129 | [The selection of best anesthesiological technique for hip fracture surgery in older high-risk patients]. | Hip fracture is a pathological condition, more common in older age, i.e. in people over 65 years. The prevalence of this disorder is continuously increasing, simultaneously with higher age limit. In evaluation of risk for operation and anesthesia, older age itself represents higher risk and calls for special attention.... |
2,334,130 | Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI). | Both cardiac myocytes and cardiac stem cells (CSCs) express the receptor of growth hormone releasing hormone (GHRH), activation of which improves injury responses after myocardial infarction (MI). Here we show that a GHRH-agonist (GHRH-A; JI-38) reverses ventricular remodeling and enhances functional recovery in the se... |
2,334,131 | Fetal outcome in autoimmune diseases. | The impact on fetal outcome in women with autoimmune diseases is a result of a several conditions. Fetal success depends on early immunological changes in the mother, which rely in modifications of the innate and adaptative immune system, inducing tolerance to the semi-allogenic fetus. Others crucial factors are matern... |
2,334,132 | Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation. | The increase in cerebral blood flow (CBF) during neuronal activation can be only partially attenuated by individual inhibitors of epoxyeicosatrienoic acids (EETs), cyclooxgenase-2, group I metabotropic glutamate receptors (mGluR), neuronal nitric oxide synthase (nNOS), N-methyl-D-aspartate receptors, or adenosine recep... |
2,334,133 | Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome. | The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. This simulation study identifies arrhythmogenic mechanisms in the rapid-delayed rectifier K(+) current (I(Kr))-linked SQT1 variant of the SQTS. ... |
2,334,134 | Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human? | Repolarization-dependent cardiac arrhythmias only arise in hearts facing multiple 'challenges' affecting its so-called repolarization reserve. Congestive heart failure (CHF) is one such challenge frequently observed in humans and is accompanied by altered calcium handling within the contractile heart cell. This raises ... |
2,334,135 | A comparative study of duration of postoperative analgesia between epidural bupivacaine and epidural clonidine plus bupivacaine in lumbar laminectomy surgery under general anaesthesia. | A randomised prospective double-blind placebo controlled study was undertaken in 60 patients of ASA-I and II, scheduled for lumbar laminectomy under general anaesthesia using thiopentone, fentanyl, artracurium, N2O/O2 and isoflurane. After obtaining written Informed consent from all patients, they were randomly allocat... |
2,334,136 | In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. | Using a new class of nontoxic and degradable glycopolymer-based vehicles termed poly(glycoamidoamine)s, we demonstrate virus-like delivery efficacy of oligodeoxynucleotide (ODN) decoys to cardiomyoblasts (H9c2), primary cardiomyocytes, and the mouse heart. These glycopolymers bind and compact ODN decoys into nanopartic... |
2,334,137 | [Effects of 15 mcg intrathecal clonidine added to bupivacaine and sufentanil for labor analgesia]. | For the combined spinal epidural analgesia for labour, 30 mcg of subarachnoid clonidine has proved its effectiveness to extend the analgesia, but increased severe hemodynamic effects.</AbstractText>To assess the effectiveness and the safety of 15 mcg intra thecal clonidine for labour analgesia.</AbstractText>Four month... |
2,334,138 | Latent Epstein-Barr virus can inhibit apoptosis in B cells by blocking the induction of NOXA expression. | Latent Epstein-Barr virus (EBV) has been shown to protect Burkitt's lymphoma-derived B cells from apoptosis induced by agents that cause damage to DNA, in the context of mutant p53. This protection requires expression of the latency-associated nuclear proteins EBNA3A and EBNA3C and correlates with their ability to coop... |
2,334,139 | Misleading ECG recordings. | Misleading electrocardiogram recordings are not uncommon, and can lead to misdiagnosis. This article highlights two examples and discusses the strategies to recognise them. |
2,334,140 | Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension. | MicroRNAs (miRs) control various cellular processes in tissue homeostasis and disease by regulating gene expression on the posttranscriptional level. Recently, it was demonstrated that the expression of miR-21 and members of the miR-17-92 cluster was significantly altered in experimental pulmonary hypertension (PH).</A... |
2,334,141 | Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. | Explanations for arrhythmia mechanisms at the cellular level are usually based on experiments in nonhuman myocytes. However, subtle electrophysiological differences between species may lead to different rhythmic or arrhythmic cellular behaviors and drug response given the nonlinear and highly interactive cellular syste... |
2,334,142 | Ro52 autoantibody-positive women's experience of being pregnant and giving birth to a child with congenital heart block. | congenital heart block may develop in the fetus of women with Ro/SSA autoantibodies. The aim of this study was to investigate how women expecting a child with congenital heart block (CHB) experienced their pregnancy and post-partum period.</AbstractText><AbstractText Label="DESIGN, SETTING AND PARTICIPANTS" NlmCategory... |
2,334,143 | The effect of the intravenous phenylephrine on the level of spinal anesthesia. | Spinal anesthesia causes hypotension and bradycardia due to sympathetic nerve block and it is difficult to predict the level of sensory block and the duration of blockade. Recent studies have reported that intravenous phenylephrine can reduce the rostral spread of spinal anesthesia in pregnant women. We think a phenyle... |
2,334,144 | Addition of intrathecal Dexamethasone to Bupivacaine for spinal anesthesia in orthopedic surgery. | Spinal anesthesia has the advantage that profound nerve block can be produced in a large part of the body by the relatively simple injection of a small amount of local anesthetic. Intrathecal local anesthetics have limited duration. Different additives have been used to prolong spinal anesthesia. The effect of corticos... |
2,334,145 | Novel biodegradable, biomimetic and functionalised polymer scaffolds to prevent expansion of post-infarct left ventricular remodelling. | Over the past decade, a large number of strategies and technologies have been developed to reduce heart failure progression. Among these, cardiac tissue engineering is one of the most promising. Aim of this study is to develop a 3D scaffold to treat cardiac failure. A new three-block copolymer, obtained from δ-va... |
2,334,146 | Side effects and complications of intraosseous anesthesia and conventional oral anesthesia. | To analyze the side effects and complications following intraosseous anesthesia (IA), comparing them with those of the conventional oral anesthesia techniques.</AbstractText>A simple-blind, prospective clinical study was carried out. Each patient underwent two anesthetic techniques: conventional (local infiltration and... |
2,334,147 | Sympathetic nerve stimulation induces local endothelial Ca2+ signals to oppose vasoconstriction of mouse mesenteric arteries. | It is generally accepted that the endothelium regulates vascular tone independent of the activity of the sympathetic nervous system. Here, we tested the hypothesis that the activation of sympathetic nerves engages the endothelium to oppose vasoconstriction. Local inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) sig... |
2,334,148 | Gliosis in the mouse hippocampus without neuronal death after systemic administration of high dosage of tetanus toxin. | Tetanus toxin (TeT), an exotoxin, has been studied to cause tetanus in mammalian brains, and it can block the release of some neurotransmitters and affect seizure propagation. In the present study, we investigated neuronal damage/death and glial changes in the mouse hippocampus after systemic administration (intraperit... |
2,334,149 | Prenatal diagnosis and outcome of fetuses with double-inlet left ventricle. | The aim of this study is to characterize the in utero presentation of the subtype of double-inlet left ventricle (DILV), a rare congenital heart disease, and assess the postnatal outcome. We retrospectively studied fetuses diagnosed prenatally with DILV between 2007 and 2011. We reviewed the prenatal and postnatal echo... |
2,334,150 | Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors. | Blockade of the renin-angiotensin system (RAS) is well recognized as an essential therapy in hypertensive, heart, and kidney diseases. There are several classes of drugs that block the RAS; these drugs are known to exhibit antifibrotic action. An analysis of the molecular mechanisms of action for these drugs can reveal... |
2,334,151 | Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. | Endothelin-2 [ET-2; also known as vasoactive intestinal contractor (VIC), in rodents] differs from endothelin-1 (ET-1) by only two amino acids, and unlike the third isoform, endothelin-3 (ET-3), it has the same affinity as ET-1 for both ET(A) and ET(B) receptors. It is often assumed that ET-2 would mimic the actions of... |
2,334,152 | The analgesic effect of dexketoprofen when added to lidocaine for intravenous regional anaesthesia: a prospective, randomized, placebo-controlled study. | This prospective, randomized, placebo-controlled study evaluated the effects of dexketoprofen as an adjunct to lidocaine in intravenous regional anaesthesia (IVRA) or as a supplemental intravenous (i.v.) analgesic. Patients scheduled for elective hand or forearm soft-tissue surgery were randomly divided into three grou... |
2,334,153 | Comparison of bupivacaine femoral and sciatic nerve block versus bupivacaine and morphine epidural for stifle surgery in dogs. | To evaluate the efficacy of combined femoral and sciatic nerve blocks as an alternative to epidural anesthesia and analgesia in dogs undergoing stifle surgery under general anesthesia.</AbstractText>Prospective, blinded, randomized, clinical comparison.</AbstractText>Twenty dogs weighing 37 ± 11 (mean ± SD) k... |
2,334,154 | New mechanism of spiral wave initiation in a reaction-diffusion-mechanics system. | Spiral wave initiation in the heart muscle is a mechanism for the onset of dangerous cardiac arrhythmias. A standard protocol for spiral wave initiation is the application of a stimulus in the refractory tail of a propagating excitation wave, a region that we call the "classical vulnerable zone." Previous studies of vu... |
2,334,155 | Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. | Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch re... |
2,334,156 | Arrhythmias following spinal anesthesia for cesarean delivery - Is Wenckebach common? | Arrhythmias in pregnancy are common and may cause concern for the well-being of both mother and fetus. Generally, no previous history of heart disease is elicited and majority of the arrhythmias are benign. Bradycardia is commonly seen following subarachnoid block for cesarean section. However, the incidence of subsequ... |
2,334,157 | Effects of moderate exercise on VLDL₁ and Intralipid kinetics in overweight/obese middle-aged men. | Prior moderate exercise reduces plasma triglyceride (TG)-rich lipoprotein concentrations, mainly in the large very low-density lipoprotein (VLDL₁) fraction, but the mechanism responsible is unclear. We investigated the effects of brisk walking on TG-rich lipoprotein kinetics using a novel method. Twelve overweig... |
2,334,158 | [Evaluation of safety and anesthetic effect for ultrasound-guided cervical plexus block]. | To observe the influences upon the degree of diaphragmatic excursion during deep cervical plexus block at the third cervical vertebra (C3) and compare the safety and anesthetic effect of modified cervical plexus block by ultrasonic guidance and blocking of cervical plexus at one point.</AbstractText>Part I: 30 patients... |
2,334,159 | Volume kinetics of acetated Ringer's solution during experimental spinal anaesthesia. | General anaesthesia lowers the clearance of crystalloid fluid, but the volume kinetics of such fluid throughout the duration of spinal anaesthesia has not been studied.</AbstractText>Ten female volunteers (mean age 29 years) received an intravenous infusion of 25 ml/kg of acetated Ringer's solution with and without spi... |
2,334,160 | Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. | The xCELLigence real time cell analyzer Cardio system offers a new system for real-time cell analysis that measures impedance-based signals in a label-free noninvasive manner. The aim of this study was to test whether impedance readings are a useful tool to detect compound effects on beating frequency (beats per minute... |
2,334,161 | Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-α. | Transgenic mice overexpressing tumor necrosis factor-α (TNF-α mice) possess many of the features of human heart failure, such as dilated cardiomyopathy, impaired Ca(2+) handling, arrhythmias, and decreased survival. Although TNF-α mice have been studied extensively with a number of experimental method... |
2,334,162 | Rosuvastatin blocks hERG current and prolongs cardiac repolarization. | Blocking of the potassium current I(Kr) [human ether-a-go-go related gene (hERG)] is generally associated with an increased risk of long QT syndrome (LQTS). The 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor, rosuvastatin, is a methanesulfonamide derivative, which shows structural similarities with several ... |
2,334,163 | Differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation. | Neonatal asphyxia can be complicated by myocardial dysfunction with secondary alterations in pulmonary and regional hemodynamics. Levosimendan is a calcium-sensitizing inotrope that may support cardiac output, but little is known regarding its differential hemodynamic effects in asphyxiated neonates.</AbstractText>Mixe... |
2,334,164 | Comparison of epidural tramadol-ropivacaine and fentanyl-ropivacaine for labor analgesia: a prospective randomized study. | To test the hypothesis that 5 mg/mL tramadol is superior to 3 ?g/mL fentanyl when combined with 0.125% ropivacaine in parturients undergoing labor during epidural analgesia.</AbstractText>Sixty-one parturients undergoing labor selected for delivery with epidural analgesia were randomized into two groups: Group tramadol... |
2,334,165 | Suturing of penetrating wounds to the heart in the nineteenth century: the beginnings of heart surgery. | The beginnings of cardiac surgery go back to the 19th century. This article describes the history of the first attempts to operate on the heart. In 1882, Dr Block from Danzig, and in 1895, Simplicio Del Vecchio, published reports of animal experiments showing that the suturing of heart wounds is possible. After unsucce... |
2,334,166 | Comparison of intranasal methamphetamine and d-amphetamine self-administration by humans. | There are no studies directly comparing self-administration of methamphetamine and d-amphetamine by humans. This study compared intranasal methamphetamine- and d-amphetamine self-administration and characterized the mood, performance and physiological effects produced by the drugs.</AbstractText>A randomized, double-bl... |
2,334,167 | Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block. | Hyperkalemia affects the myocardial tissue producing electrocardiographic abnormalities, such as prolongation of the P-R interval, tall peaked T waves, a reduction in the amplitude and an increase in the duration of P wave, and atrial and ventricular arrhythmias, including variable degree heart blocks. Elderly patients... |
2,334,168 | [Ephedrine vs. phenylephrine by intravenous bolus and continuous infusion to prevent hypotension secondary to spinal anesthesia during cesarean section: a randomized comparative trial]. | Subarachnoid spinal anesthesia for cesarean section is associated with a high incidence of hypotension, which can require the use of vasoconstrictors. The aim of this trial was to compare ephedrine to phenylephrine for the prevention of secondary hypotension and to assess the adverse effects on both mother and newborn.... |
2,334,169 | Effect of a telemonitoring-facilitated collaboration between general practitioner and heart failure clinic on mortality and rehospitalization rates in severe heart failure: the TEMA-HF 1 (TElemonitoring in the MAnagement of Heart Failure) study. | Chronic heart failure (CHF) patients are frequently rehospitalized within 6 months after an episode of fluid retention. Rehospitalizations are preventable, but this requires an extensive organization of the healthcare system. In this study, we tested whether intensive follow-up of patients through a telemonitoring-faci... |
2,334,170 | Influence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes. | Modulation of L-type Ca(2+) current (I(Ca,L)) by H(+) ions in cardiac myocytes is controversial, with widely discrepant responses reported. The pH sensitivity of I(Ca,L) was investigated (whole cell voltage clamp) while measuring intracellular Ca(2+) (Ca(2+)(i)) or pH(i) (epifluorescence microscopy) in rabbit and guine... |
2,334,171 | Transmitochondrial mice as models for mitochondrial DNA-based diseases. | Mitochondrial genome (mtDNA) mutations and the resultant mitochondrial respiratory abnormalities are associated with a wide variety of disorders, such as mitochondrial diseases, neurodegenerative diseases, diabetes, and cancer, as well as aging. Generation of model animals carrying mutant mtDNAs is important for unders... |
2,334,172 | The effects of paeoniflorin monomer of a Chinese herb on cardiac ion channels. | Because of the potential proarrhythmic effect of current antiarrhythmic drugs, it is still desirable to find safer antiarrhythmic drugs worldwide. Paeoniflorin is one of the Chinese herb monomers that have different effects on many ion channels. The present study aimed to determine the effects of paeoniflorin on cardia... |
2,334,173 | Cognitive reserve moderates the association between heart failure and cognitive impairment. | Cognitive impairment in persons with heart failure is common. Theories of cognitive reserve suggest that premorbid factors, such as intellectual ability, may provide a buffer against cognitive impairment due to neuropathological insult. No study has examined the influence of cognitive reserve on cognitive functioning i... |
2,334,174 | Enhancing effects of salicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels. | It is unknown whether salicylate enhances the action of antiarrhythmic agents on human Na+ channels with state dependency and tissue specificity. We therefore investigated effects of salicylate on quinidine-induced block of human cardiac and skeletal muscle Na+ channels. Human cardiac wild-type (hH1), LQT3-related muta... |
2,334,175 | The metabolic and toxicological considerations for mTOR inhibitors in the treatment of hepatocarcinoma. | Hepatocellular carcinoma (HCC) is a major health problem worldwide. Several molecular pathways involved in HCC growth and progression have recently been identified. Rapamycin analogs are able to inhibit one of the most active oncogenic molecular pathways in HCC cells: the mammalian target of rapamycin (mTOR) pathway.</... |
2,334,176 | Irrigated-tip vs. conventional-tip catheters for primary ablation of posteroseptal and right free-wall accessory pathways: a prospective randomized study. | The use of irrigated-tip catheters enables elimination of almost all accessory pathways (APs) resistant to standard radiofrequency ablation (RFA). However, efficacy of irrigation catheter technology in the initial AP ablation has not been studied systematically yet.</AbstractText>We tested whether the externally irriga... |
2,334,177 | Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. | Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the development of diabetic cardiomyopathy. Phosphorothioated antisense (AS) or sense (S) oligonucleotides for Nox4 were administered for 2 wk to rats ... |
2,334,178 | [Assessment of renal function, iatrogenic hyperkalemia and acute renal dysfunction in cardiology. Contrast-induced nephropathy]. | Renal impairment influences the prognosis of patients with cardiovascular disease and increases cardiovascular risk. Renal dysfunction is a marker of lesions in other parts of the vascular tree and detection facilitates early identification of individuals at high risk of cardiovascular events. In patients with cardiova... |
2,334,179 | Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. | The use of long-chain fatty acids (LCFAs) for energy is inhibited in inherited disorders of long-chain fatty acid oxidation (FAO). Increased energy demands during exercise can lead to cardiomyopathy and rhabdomyolysis. Medium-chain triglycerides (MCTs) bypass the block in long-chain FAO and may provide an alternative e... |
2,334,180 | Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. | Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. When suspended in human or animal plasma, staphylococci are known to agglutinate, however the bacterial factors responsible for agglutination and their possible contributi... |
2,334,181 | Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels. | Activation of small-conductance calcium (Ca(2+))-dependent potassium (K(Ca)2) channels (herein called "SK") produces membrane hyperpolarization to regulate membrane excitability. Three subtypes (SK1-3) have been cloned and are distributed throughout the nervous system, smooth muscle, and heart. It is difficult to disce... |
2,334,182 | Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. | In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI).</AbstractText>To characterize RyR functional properties in relation to TT proximity, at baseline and after MI.</Abst... |
2,334,183 | Echocardiographic diagnosis and prognosis of fetal left ventricular noncompaction. | Left ventricular noncompaction (LVNC) has rarely been described in the fetus.</AbstractText>The presence of associated congenital heart disease and rhythm disturbance was identified and the presence of heart failure was assessed using the cardiovascular profile score in all fetuses with LVNC presenting from January 199... |
2,334,184 | Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)/uPA receptor-dependent activation of TGF-β and potentiates fibrosis. | In congenital heart block (CHB), binding of maternal anti-SSA/Ro Abs to fetal apoptotic cardiocytes impairs their removal by healthy cardiocytes and increases urokinase plasminogen activator (uPA)/uPA receptor (uPAR)-dependent plasmin activation. Because the uPA/uPAR system plays a role in TGF-β activation, we ev... |
2,334,185 | Chronic phase of Chagas disease: why should it be treated? A comprehensive review. | The pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue regeneration to prevent fibrosis, (iii) reverse existing fibrosis,... |
2,334,186 | Cardiac specific effects of thyroid hormone analogues. | There is significant interest in development of thyroid hormone analogues to harness specific properties as therapeutic agents for a variety of clinical indications including obesity, hypercholesterolemia, heart failure, and thyrotoxicosis. To date, most analogues have been designed to target liver specific effects, wh... |
2,334,187 | The cardiogenic niche as a fundamental building block of engineered myocardium. | Cardiac muscle engineering is evolving rapidly, aiming at the provision of innovative models for drug development and therapeutic myocardium. The progress in this field will depend crucially on the proper exploitation of stem cell technologies. Understanding the processes governing stem cell differentiation towards a d... |
2,334,188 | MERRF and Kearns-Sayre overlap syndrome due to the mitochondrial DNA m.3291T>C mutation. | A 48-year-old man presented with a complex phenotype of myoclonus epilepsy with ragged-red fibers (MERRF) syndrome and Kearns-Sayre syndrome (KSS), which included progressive myoclonus epilepsy, cerebellar ataxia, hearing loss, myopathic weakness, ophthalmoparesis, pigmentary retinopathy, bifascicular heart block, and ... |
2,334,189 | Severe cardiovascular depression in a cat following a mandibular nerve block with bupivacaine. | A 12 year old cat was presented for anaesthesia to remove a mandibular squamous cell carcinoma. After intramuscular premedication with dexmedetomidine and methadone, anaesthesia was induced with alfaxalone, administered intravenously (IV) to effect, and maintained with isoflurane vaporized in oxygen, following oro-trac... |
2,334,190 | Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. | The epidemic of overweight and obesity around the world and in the US is a major public health challenge, with 1.5 billion overweight and obese adults worldwide, and 68% of US adults and 31% of US children and adolescents overweight or obese. Obesity leads to serious health consequences, including an increased risk of ... |
2,334,191 | New kids on the block: the emerging role of apolipoproteins in the pathogenesis and treatment of asthma. | New treatments are needed for patients with severe asthma. We hypothesized that a clinically relevant experimental model of house dust mite (HDM)-induced murine asthma could be used to discover new pathways that regulate disease severity. In HDM-challenged mice, genome-wide expression profiling of the asthmatic lung tr... |
2,334,192 | Effects of sitting up for five minutes versus immediately lying down after spinal anesthesia for Cesarean delivery on fluid and ephedrine requirement; a randomized trial. | Patient position after spinal anesthesia has had variable effects on blood pressure and ephedrine requirements. The aim of this study was to determine the effects that sitting the patient up for five minutes after spinal anesthesia would have on intraoperative fluid and ephedrine requirements.</AbstractText>The study i... |
2,334,193 | Single level paravertebral versus caudal block in paediatric inguinal surgery. | Paravertebral block (PVB) has been used for postoperative analgesia in children since 1992. There are no prospective randomised studies comparing the use of PVB versus caudal block (CB) for outpatient inguinal hernia repair surgery. The hypothesis of this study is that a single level, single injection PVB can provide a... |
2,334,194 | Effect of cleistanthin A and B on adrenergic and cholinergic receptors. | The aim was to study the in vitro and in silico interactions of cleistanthin A and B on the adrenergic and cholinergic receptors using isolated animal tissues and bioinformatics tools.</AbstractText>The alpha adrenergic receptor activities of cleistanthin A and B were studied in vitro using a guinea pig vas deferens pr... |
2,334,195 | A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions. | In this study, several modifications were introduced to a recently proposed human ventricular action potential (AP) model so as to render it suitable for the study of ventricular arrhythmias. These modifications were driven by new sets of experimental data available from the literature and the analysis of several well-... |
2,334,196 | Proximity to food establishments and body mass index in the Framingham Heart Study offspring cohort over 30 years. | Existing evidence linking residential proximity to food establishments with body mass index (BMI; weight (kg)/height (m)(2)) has been inconclusive. In this study, the authors assessed the relation between BMI and proximity to food establishments over a 30-year period among 3,113 subjects in the Framingham Heart Study O... |
2,334,197 | Unilateral stellate ganglion block produces bidirectional changes in tissue oxygen tension of the mental nerve in rabbits. | The purpose of this study was to investigate changes in the tissue oxygen tension (PO(2)) of the mental nerve bilaterally before and after unilateral stellate ganglion block (SGB).</AbstractText>Nine male Japan white rabbits were used. Anesthesia was maintained by a continuous infusion of propofol under mechanical vent... |
2,334,198 | Epidural anesthesia and post-operative analgesia for bilateral inguinal mesh hernioplasty: Comparison of equipotent doses of ropivacaine and bupivacaine. | Ropivacaine is a long-acting amide local anesthetic, which is structurally very similar to bupivacaine but produces less motor block and less cardiac and central nervous system toxicity. It is also about 40% less potent than bupivacaine. Our double blind study was designed to compare the clinical efficacy of the equipo... |
2,334,199 | The evaluation of upper leg traction in lateral position for pediatric caudal block. | A well-functioning caudal block is an excellent adjunct to general anesthesia, but misplaced injection results in poor analgesia as well as possibility of serious morbidity. Therefore, the purpose of this study was to evaluate the effectiveness of leg traction on success rate of caudal block in lateral position in chil... |
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