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2,334,500 | Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers. | The lipid headgroup plays an important role in the association of polymers with lipid bilayer membranes. Herein, we report how a glycerol headgroup versus a choline headgroup affects the interaction of poly(ethylene oxide)-<i>b</i>-poly(propylene oxide) (PEO-PPO) block copolymers with lipid bilayer vesicles. Unilamella... |
2,334,501 | Effects of intravenous dexmedetomidine on spinal anesthesia and sedation - A comparison of two different maintenance infusions. | Our aim was to study the effects of a low-dose bolus (0.5 mcg/kg) of dexmedetomidine followed by two different infusion doses (0.25, 0.5 mcg/kg/h) on spinal anesthesia, sedation, hemodynamics and side effects.</AbstractText>Eighty consenting patients were randomized into two groups A and B with 40 patients each. Patien... |
2,334,502 | Efficacy of multimodal analgesia with perineural buprenorphine or dexmedetomidine for surgeries performed under ultrasound-guided infraclavicular brachial plexus block. | Perineural adjuvants when used as a part of multimodal analgesia (MMA) will maximize the quality and duration of analgesia of the nerve blocks. In the present study, we compared the duration of postoperative analgesia and other block characteristics of two groups of MMA comprising either perineural buprenorphine or dex... |
2,334,503 | Quantitative assessment of near-infrared spectroscopy time course under hypercapnia using an a priori model-based fitting. | Partial arterial pressure of carbon dioxide (CO2</sub>) modulates cerebral blood flow through a vasoreactivity mechanism. Near infrared spectroscopy (NIRS) can be used to record these changes in cerebral hemodynamics. However, no laterality comparison of the NIRS signal has been performed despite being a prerequisite f... |
2,334,504 | Post-Cardiotomy Parasternal Nerve Block with Bupivacaine may be Associated with Reduced Post-Operative Opioid Use in Children: A Retrospective Cohort Study. | Postoperative pain treatment affects immediate and long-term outcomes in children undergoing cardiac surgery. Opioids, as part of multimodal analgesia, are effective in treating pain, however, they can be disadvantageous due to adverse side effects. Therefore, we assessed whether the local anesthetic bupivacaine as a p... |
2,334,505 | Association of Neighborhood Measures of Social Determinants of Health With Breast, Cervical, and Colorectal Cancer Screening Rates in the US Midwest. | Despite advances in cancer treatment and cancer-related outcomes, disparities in cancer mortality remain. Lower rates of cancer prevention screening and consequent delays in diagnosis may exacerbate these disparities. Better understanding of the association between area-level social determinants of health and cancer sc... |
2,334,506 | Enhancement of Loading Efficiency by Coloading of Doxorubicin and Quercetin in Thermoresponsive Polymeric Micelles. | Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using γ-benzyloxy substituted p... |
2,334,507 | Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life. | This study uses Medicare claims data to identify and assess disparities in the use of advance care planning among adults 65 years or older who died between 2000 and 2015 and received intensive care during the last 30 days of life. |
2,334,508 | [Application of dural puncture epidural technique for labor analgesia]. | <b>Objective:</b> To investigate the effects of dural puncture epidural technique for labor analgesia on mothers and neonates. <b>Methods:</b> From January to June 2019, one hundred healthy and nulliparous women, scheduled for elective labor analgesia in the Second Affiliated Hospital of Wenzhou Medical University, met... |
2,334,509 | Postoperative pain management for circumcision; Comparison of frequently used methods. | To determine the ideal method for postoperative pain management after circumcision by comparing the most frequently used different methods like; dorsal penile block, caudal epidural block, subcutaneous ring block, intravenous paracetamol and intravenous tramadol HCl.</AbstractText>Between May 1st</sup> 2015 to May 1st<... |
2,334,510 | Measures of Poor Sleep Quality Are Associated With Higher Energy Intake and Poor Diet Quality in a Diverse Sample of Women From the Go Red for Women Strategically Focused Research Network. | Background Poor sleep increases cardiovascular disease risk, and diet likely contributes to this relationship. However, there are limited epidemiological data on the relationship between measures of sleep quality and habitual dietary patterns. This study examined these associations in a diverse sample of women. Methods... |
2,334,511 | Novel Predictors of New Persistent Left Bundle Branch Block After SAPIEN 3 Transcatheter Aortic Valve Replacement.<Pagination><StartPage>1141</StartPage><EndPage>1143</EndPage><MedlinePgn>1141-1143</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcin.2019.10.053</ELocationID><ELocationID EIdTy... | Solid organ transplantation has been made possible by the development of potent immunosuppressive agents which block cellular rejection adequately for survival of the transplanted organ and induction of at least partial tolerance. The first regimens that were found to successfully prevent cellular rejection consisted o... |
2,334,512 | Comparing the prophylactic effects of oral gabapentin, pregabalin, and celecoxib on postoperative pain management in orthopedic surgery of the lower extremity: A double-blind randomized controlled trial. | Lower extremity pain after orthopedic surgery is so frequent that has led to many treatment modalities. This study aims to compare the prophylactic effects of oral gabapentin, pregabalin, and celecoxib on reducing postsurgical pain of the lower extremity orthopedic surgery.</AbstractText>In a double-blind randomized co... |
2,334,513 | Effect of Scalp Nerve Block with Ropivacaine on Postoperative Pain in Patients Undergoing Craniotomy: A Randomized, Double Blinded Study. | Scalp nerve block with ropivacaine has been shown to provide perioperative analgesia. However, the best concentration of ropivacaine is still unknown for optimal analgesic effects. We performed a prospective study to evaluate the effects of scalp nerve block with varied concentration of ropivacaine on postoperative pai... |
2,334,514 | Ryanodine receptor modulation by caffeine challenge modifies Na<sup>+</sup> current properties in intact murine skeletal muscle fibres. | We investigated effects of the ryanodine receptor (RyR) modulator caffeine on Na<sup>+</sup> current (I<sub>Na</sub>) activation and inactivation in intact loose-patch clamped murine skeletal muscle fibres subject to a double pulse procedure. I<sub>Na</sub> activation was examined using 10-ms depolarising, V<sub>1</sub... |
2,334,515 | Locally optimized correlation-guided Bayesian adaptive regularization for ultrasound strain imaging. | Ultrasound strain imaging utilizes radio-frequency (RF) ultrasound echo signals to estimate the relative elasticity of tissue under deformation. Due to the diagnostic value inherent in tissue elasticity, ultrasound strain imaging has found widespread clinical and preclinical applications. Accurate displacement estimati... |
2,334,516 | Effects of utilizing cotton byproducts in a finishing diet on beef cattle performance, carcass traits, fecal characteristics, and plasma metabolites. | Increased cotton production in the Southwestern United States has increased the availability of cotton byproducts for use in cattle diets. The objective of this experiment was to evaluate the inclusion of cotton byproducts in feedlot finishing diets on the performance, carcass traits, fecal characteristics, and plasma ... |
2,334,517 | Intravenous Fentanyl 4 μg per kg Administered before Scalp Pin Application is Inferior to Scalp Block in Preventing Hemodynamic Changes. | Application of scalp pins for craniotomy surgeries is a noxious stimulus, causing tachycardia and hypertension, resulting in increased cerebral blood flow and elevated intracranial pressure, hence measures to attenuate this will have beneficial role.</AbstractText>The aim is to compare the effectiveness of scalp block ... |
2,334,518 | A Comparative Study of Tramadol and Clonidine as an Additive to Levobupivacaine in Caudal Block in Pediatric Patients Undergoing Perineal Surgeries. | Caudal block is a simple, safe procedure with fewer side effects to provide intraoperative and postoperative analgesia in pediatric patients. Many drugs were used as an additive to local anesthetics in caudal block. All these drugs had their own side effects.</AbstractText>In this study, we compare the effects of trama... |
2,334,519 | [Analysis of sugammadex for antagonistic neuromuscular block in patients with radical resection of lung cancer under thoracoscope]. | <b>Objective:</b> To investigate the efficacy and safety of sugammadex for antagonistic neuromuscular block in patients with radical resection of lung cancer under thoracoscope. <b>Methods:</b> One hundred patients undergoing radical resection of lung cancer under thoracoscope in Affiliated Cancer Hospital of Zhengzhou... |
2,334,520 | Fungal infection in a post-renal transplant patient with <i>Diaporthe</i>. | Post-renal transplant fungal infections continue to be a major cause of mortality and morbidity. Universally reported fungi are Candida, especially Candida albicans, Cryptococcus, Aspergillus, Trichophyton rubrum and Pityriasis versicolor. Here, we report a case of infection caused by a rare fungus Diaporthe. It is an ... |
2,334,521 | A randomized double-blind comparison of the double-space technique versus the single-space technique in combined spinal-epidural anesthesia for cesarean section. | Combined spinal-epidural anesthesia (CSEA) can be performed with either a single-space technique or a double-space technique for cesarean section. We performed a double-blind randomized controlled study to compare the effect of the double-space technique with that of the single-space technique on sensory block level an... |
2,334,522 | Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis. | The canalicular system (CS) has been defined as: <b>1)</b> an inward, invaginated membrane connector that supports entry into and exit from the platelet; <b>2)</b> a static structure stable during platelet isolation; and <b>3)</b> the major source of plasma membrane (PM) for surface area expansion during activation. Re... |
2,334,523 | Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. | Fatty acid oxidation (FAO) is a key bioenergetic pathway often dysregulated in diseases. The current knowledge on FAO regulators in mammalian cells is limited and sometimes controversial. Previous FAO analyses involve nonphysiological culture conditions or lack adequate quantification. We herein described a convenient ... |
2,334,524 | Is it feasible "scoop and run while playing" resuscitation on a rescue water craft? A randomized simulation study with lifeguards. | Response time is a predictive factor for survival of drowning victims and lifesaving. Rescue Water Craft (RWC) are lifeboats very common in lifeguards operations. The aim of this study was to analyze the feasibility of providing effective mouth-to-mouth ventilations and/or cardiopulmonary resuscitation (CPR) on the RWC... |
2,334,525 | Early Season Hormonal and Biochemical Changes in Division I Field Hockey Players: Is Fitness Protective? | Walker, AJ, McFadden, BA, Sanders, DJ, Bozzini, BN, Conway, SP, and Arent, SM. Early season hormonal and biochemical changes in Division I field hockey players: is fitness protective? J Strength Cond Res 34(4): 975-981, 2020-The purpose was to evaluate changes in hormonal and biochemical markers as a result of the accu... |
2,334,526 | [Effect of Aromatherapy on Menopausal Symptoms, Heart Rate Variability, and Sleep Quality in Women]. | Studies have shown that aromatherapy improve health problems related to anxiety, depression, heart rate variability (HRV), and sleep. However, the effect of aromatherapy in women who suffer from menopausal syndrome and its specific effects on HRV and sleep quality are unknown.</AbstractText>This study designed an aroma... |
2,334,527 | Comparison of peribulbar block and general anaesthesia in mechanical vitrectomy: a prospective observational study. | Vitrectomy surgery is a common procedure for the treatment of several types of ophthalmologic conditions. It can be performed under regional anaesthesia with peribulbar block (PB) or general anaesthesia (GA). There are no evidence-based recommendations on the optimal anaesthesia strategy for this procedure. The aim of ... |
2,334,528 | A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution. | To investigate fetal/perinatal and maternal outcomes from a large multicentre cohort of women diagnosed with UCTD.</AbstractText>This multicentre retrospective cohort study describes the outcomes of 224 pregnancies in 133 consecutive women with a diagnosis of UCTD, positive for ANA and aged <45 years old at s... |
2,334,529 | Super-resolution of cardiac magnetic resonance images using Laplacian Pyramid based on Generative Adversarial Networks. | Cardiac magnetic resonance imaging (MRI) can assist in both functional and structural analysis of the heart, but due to hardware and physical limitations, high-resolution MRI scans is time consuming and peak signal-to-noise ratio (PSNR) is low. The existing super-resolution methods attempt to resolve this issue, but th... |
2,334,530 | Rehabilitation Intervention for Individuals With Heart Failure and Fatigue to Reduce Fatigue Impact: A Feasibility Study. | To investigate feasibility of recruitment, tablet use in intervention delivery, and use of self-report outcome measures and to analyze the effect of Energy Conservation plus Problem-Solving Therapy versus Health Education interventions for individuals with heart failure-associated fatigue.</AbstractText>This feasibilit... |
2,334,531 | Temporal registration: a new approach to manage the incomplete recovery of the longitudinal magnetization in the Modified Look-Locker Inversion Recovery sequence (MOLLI) for T1 mapping of the heart. | To correct with post-processing effects of incomplete recovery of the longitudinal magnetization before a new inversion pulse in the Modified Look-Locker Inversion recovery sequence (MOLLI) sequence.</AbstractText>We model such effects as a temporal shift ([Formula: see text]) of the signal of the Look-Locker block fol... |
2,334,532 | Dexmedetomidine during suprazygomatic maxillary nerve block for pediatric cleft palate repair, randomized double-blind controlled study. | For children with cleft palates, surgeries at a young age are necessary to reduce feeding or phonation difficulties and reduce complications, especially respiratory tract infections and frequent sinusitis. We hypothesized that dexmedetomidine might prolong the postoperative analgesic duration when added to bupivacaine ... |
2,334,533 | Early experience with erector spinae plane blocks in children. | An erector spinae plane block is a relatively new regional anesthetic technique. Apart from case reports and small series, the literature regarding pediatric use is limited.</AbstractText>Our objective was to determine the efficacy of the erector spinae plane block in children by measuring the heart rate response to in... |
2,334,534 | Role of erector spinae plane block versus paravertebral block in pain control after modified radical mastectomy. A prospective randomised trial. | Thoracic paravertebral block (TPVB) provides effective analgesia in breast surgery. Recently, use of erector spinae plane block (ESPB) in controlling post-operative pain has proved effective. This study aimed to compare the effect of ESPB with TPVB in post-mastectomy acute pain control.</AbstractText>A prospective, ran... |
2,334,535 | Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway. | Excessive fructose consumption induces oxidative stress and myocardial fibrosis. Antioxidant compound pterostilbene has cardioprotective effect in experimental animals. This study is aimed at investigating how fructose drove fibrotic responses via oxidative stress in cardiomyocytes and explored the attenuation mechanis... |
2,334,536 | The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma. | Approximately 5-10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation. IL-13 is involved in Th2 inflammation and has been identified as a possible therapeutic target in the treatment of asthm... |
2,334,537 | Feasibility of non-intubated anesthesia and regional block for thoracoscopic surgery under spontaneous respiration: a prospective cohort study. | Data about the feasibility and safety of thoracoscopic surgery under non-intubated anesthesia and regional block are limited. In this prospective study, 57 consecutive patients scheduled for thoracoscopic surgery were enrolled. Patients were sedated with dexmedetomidine and anesthetized with propofol and remifentanil. ... |
2,334,538 | Comparison of general anesthesia with endotracheal intubation, combined spinal-epidural anesthesia, and general anesthesia with laryngeal mask airway and nerve block for intertrochanteric fracture surgeries in elderly patients: a retrospective cohort study. | There is no consensus on the optimal anesthesia method for intertrochanteric fracture surgeries in elderly patients. Our study aimed to compare the hemodynamics and perioperative outcomes of general anesthesia with endotracheal intubation, combined spinal-epidural anesthesia, and general anesthesia with laryngeal mask ... |
2,334,539 | Access to Primary Care Physicians and Mortality in Washington State: Application of a 2-Step Floating Catchment Area. | To measure access to primary care physicians (PCPs) using a 2-step floating catchment area and explore the associations between access to PCPs and mortality related to all-causes, cancers, and heart disease in Washington State.</AbstractText>An ecological study employing generalized linear regression models of access t... |
2,334,540 | Glycans in drug discovery. | Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically relevant biological processes, glycans have come onto the scene and are considered hot spots for bio... |
2,334,541 | Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT? | Activation of the platelet Fc-receptor CD32a (FcγRIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type II (HIT) that has not been therapeutically targeted. Downstream FcγRIIA Bruton tyrosine kinase (BTK) is activated; however, its role in Fc receptor-induced platele... |
2,334,542 | Target-controlled infusion of dexmedetomidine effect-site concentration for sedation in patients undergoing spinal anaesthesia. | Dexmedetomidine has been a preferred sedative for patients undergoing regional anaesthesia and is mostly administered via conventional zero-order infusion. Recently, a pharmacokinetic-pharmacodynamic (PKPD) model of dexmedetomidine has been published, but no external validation has been reported in clinical trials. We ... |
2,334,543 | Emergent airway management outside of the operating room - a retrospective review of patient characteristics, complications and ICU stay. | Emergent airway management outside of the operating room is a high-risk procedure. Limited data exists about the indication and physiologic state of the patient at the time of intubation, the location in which it occurs, or patient outcomes afterward.</AbstractText>We retrospectively collected data on all emergent airw... |
2,334,544 | Awakening the regenerative potential of the mammalian retina. | As with all glial cells, the major role of retinal Müller glia (MG) is to provide essential neuronal support. However, the MG of some non-mammalian species have the additional ability to generate new retinal neurons capable of sight restoration. Unfortunately, mammalian MG do not possess this ability. However, if ... |
2,334,545 | Pregnancy control in patients with systemic lupus erythematosus/antiphospholipid syndrome. Part 2: Pregnancy follow-up. | In order to agree on the fundamental aspects related to the management of pregnancy in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), the Spanish Societies of Gynaecology and Obstetrics, Internal Medicine and Rheumatology set up a working group for the preparation of three consens... |
2,334,546 | Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair. | Interscalene brachial plexus block (ISB) is one of the most commonly used regional blocks in relieving postoperative pain after arthroscopic rotator cuff repair. Dexmedetomidine (DEX) is an alpha 2 agonist that can enhance the effect of regional blocks. The aim of this study was to compare the effects of DEX combined w... |
2,334,547 | S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice. | Patients with Duchenne muscular dystrophy (DMD) commonly present with severe ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also consistently observed in adult Dmdmdx mice, a mouse model of DMD, after acute β-adrenergic stimulation. These pathological features were previou... |
2,334,548 | Multiple poloxamers increase plasma membrane repair capacity in muscle and nonmuscle cells. | Various previous studies established that the amphiphilic tri-block copolymer known as poloxamer 188 (P188) or Pluronic-F68 can stabilize the plasma membrane following a variety of injuries to multiple mammalian cell types. This characteristic led to proposals for the use of P188 as a therapeutic treatment for various ... |
2,334,549 | Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly. | We describe a microfiber-shaped hepatic tissue for <i>in vitro</i> macroscopic tissue assembly, fabricated using a double coaxial microfluidic device and composed of cocultured Hep-G2 cells and human umbilical vein endothelial cells (HUVECs). The appropriate coculture conditions for Hep-G2 cells and HUVECs in the micro... |
2,334,550 | Cross-Modal Conflict Increases With Time-on-Task in a Temporal Discrimination Task. | The modality appropriateness hypothesis argues that the auditory modality is preferred over the visual modality in tasks demanding temporal operations; hence, we predicted that responses to visual stimuli would be more sensitive to the detrimental effect of Time-on-Task. We used a bimodal temporal discrimination task. ... |
2,334,551 | Stereoselective neurochemical, behavioral, and cardiovascular effects of α-pyrrolidinovalerophenone enantiomers in male rats. | The synthetic cathinone α-pyrrolidinovalerophenone (α-PVP) continues to be abused despite being banned by regulatory agencies. The abused formulation of α-PVP is a racemic mixture consisting of two enantiomers, S-α-PVP and R-α-PVP. In this study, we investigated the neurochemical, behavior... |
2,334,552 | New synonymies and transfers in Castianeira Keyserling, 1879 (Araneae, Corinnidae, Castianeirinae) from India. | Indian species in the castianeirine genus Castianeira Keyserling, 1879 (Corinnidae) are partly revised based on type materials deposited in the National Zoological Collection, Zoological Survey of India, Kolkata. Two new synonyms are recognized: Castianeira himalayensis Gravely, 1931 syn. nov. is synonymised with Corin... |
2,334,553 | Coexistence of increased arterial stiffness and interatrial block in overweight subjects.<Pagination><StartPage>e12724</StartPage><MedlinePgn>e12724</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e12724</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1111/anec.12724</ELocationID><Abstract><Abstr... | Coronary perfusion and cardiac autonomic regulation may benefit myocardial oxygen delivery and thermal performance of the teleost heart, and thus influence whole animal heat tolerance. Yet, no study has examined how coronary perfusion affects cardiac output during warming in vivo. Moreover, while β-adrenergic sti... |
2,334,554 | ACC/AHA/HRS Versus ESC Guidelines for the Diagnosis and Management of Syncope: JACC Guideline Comparison. | Syncope is a commonly encountered and challenging problem in medical practice. Presentations are variable, and the causal mechanism often remains elusive even after extensive (and often expensive) evaluation. Clinical practice guidelines have been developed to help guide the multidisciplinary approach necessary to diag... |
2,334,555 | Associations of Circadian Eating Pattern and Diet Quality with Substantial Postpartum Weight Retention. | Besides food quantity and quality, food timing and frequency may contribute to weight regulation. It is unclear if these factors during pregnancy can influence maternal weight retention after childbirth. We thus aimed to examine the associations of maternal circadian eating pattern and diet quality in pregnancy with su... |
2,334,556 | Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium. | The 5-year mortality rate for heart failure borders on 50%. The main cause is an ischaemic cardiac event where blood supply to the tissue is lost and cell death occurs. Over time, this damage spreads and the heart is no longer able to pump efficiently. Increasing vascularisation of the affected area has been shown to r... |
2,334,557 | Complete Heart Block: A Rare Complication of Takotsubo Syndrome. | Takotsubo syndrome was believed to be a rare acute cardiac event until recently with takotsubo cardiomyopathy being its most commonly recognized and often the diagnostic feature. Its diagnosis is becoming increasingly common with varied clinical manifestations most of whom have favorable clinical outcomes, yet it can b... |
2,334,558 | Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease. | T1 mapping by cardiac magnetic resonance (CMR) allows detection of abnormal myocardium. A number of myocardial abnormalities affects the signal captured in T1 mapping. We performed a systematic review and meta-analysis of native T1 and extracellular volume (ECV) in subjects with and without cardiac disease (1) to deter... |
2,334,559 | An Integrated Pipeline for Combining <i>in vitro</i> Data and Mathematical Models Using a Bayesian Parameter Inference Approach to Characterize Spatio-temporal Chemokine Gradient Formation. | All protective and pathogenic immune and inflammatory responses rely heavily on leukocyte migration and localization. Chemokines are secreted chemoattractants that orchestrate the positioning and migration of leukocytes through concentration gradients. The mechanisms underlying chemokine gradient establishment and cont... |
2,334,560 | Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment. | Multiscale computational models of the heart are being extensively investigated for improved assessment of drug-induced torsades de pointes (TdP) risk, a fatal side effect of many drugs. Model-derived metrics such as action potential duration and net charge carried by ionic currents (<i>qNet</i>) have been proposed as ... |
2,334,561 | Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury. | Spinal cord injury (SCI) can have profound effects on the autonomic and cardiovascular systems, notably with injuries above high-thoracic levels that result in the development of autonomic dysreflexia (AD) characterized by volatile hypertension in response to exaggerated sympathetic reflexes triggered by afferent stimu... |
2,334,562 | Pregnancy and Systemic Lupus Erythematosus. | As SLE onset is often in young adulthood, pregnancy is common and is usually successful. Pregnancy, though, is considered high-risk due to a combination of maternal (lupus flare, diabetes, pre-eclampsia) and fetal (miscarriage, intrauterine fetal demise, preterm birth, intrauterine growth restriction, congenital heart ... |
2,334,563 | Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus. | Mothers giving birth to children with manifestations of neonatal lupus (NL) represent a unique population at risk for the development of clinically evident pathologic autoimmunity since many are asymptomatic and only become aware of anti-SSA/Ro positivity (anti-Ro+) based on heart block in their fetus. Accordingly, we ... |
2,334,564 | Childhood Obesity and the Food Environment: A Population-Based Sample of Public School Children in New York City. | This study aimed to examine the relationship between proximity to healthy and unhealthy food outlets around children's homes and their weight outcomes.</AbstractText>A total of 3,507,542 student-year observations of height and weight data from the 2009-2013 annual FitnessGram assessment of New York City public school s... |
2,334,565 | Clinical analysis of different anesthesia methods for pulmonary infection after perioperative operation. | The purpose is to explore the effect of different anesthesia methods on pulmonary infection after the operation. 120 patients who underwent surgery from January 2015 to August 2018 were selected in three groups: group A (n=40), group B (n=40), and group C (n=40). Group A was given inhalation anesthesia, group B was giv... |
2,334,566 | Estimating the effect of calorie menu labeling on calories purchased in a large restaurant franchise in the southern United States: quasi-experimental study. | To evaluate whether calorie labeling of menus in large restaurant chains was associated with a change in mean calories purchased per transaction.</AbstractText>Quasi-experimental longitudinal study.</AbstractText>Large franchise of a national fast food company with three different restaurant chains located in the south... |
2,334,567 | Real world experience on treatment, outcome and toxicity of crizotinib in patients with anaplastic lymphoma kinase positive advanced non-small cell lung cancer. | Crizotinib has been the standard treatment for patients with anaplastic lymphoma kinase (ALK)-rearranged advanced non-small cell lung cancer (NSCLC). It demonstrated superior progression-free survival (PFS) and higher objective response rates (ORRs) vs.</i> chemotherapy in previously treated and untreated patients with... |
2,334,568 | High Effectiveness in Actions of Carfilzomib on Delayed-Rectifier K<sup>+</sup> Current and on Spontaneous Action Potentials. | Carfilzomib (CFZ, Kyprolis<sup>®</sup>) is widely recognized as an irreversible inhibitor of proteasome activity; however, its actions on ion currents in electrically excitable cells are largely unresolved. The possible actions of CFZ on ionic currents and membrane potential in pituitary GH<sub>3</sub>, A7r5 vascu... |
2,334,569 | Glucose-Sensitive Nanoparticles Based On Poly(3-Acrylamidophenylboronic Acid-Block-N-Vinylcaprolactam) For Insulin Delivery. | Compared with random copolymers, block copolymerization is easier to prepare for nanoparticles with core-shell structure, and they will have better glucose sensitivity and higher insulin loading.</AbstractText>In our study, insulin-loaded poly (3-acrylamidophenylboronic acid-block-N-vinyl caprolactam) p(AAPBA-b-NVCL) n... |
2,334,570 | A Pilot Study to Evaluate the Acceptability of Using a Smart Pillbox to Enhance Medication Adherence Among Primary Care Patients. | Smart pillboxes that remind patients to take medication may help avoid unintended non-adherence to medication regimens. To better understand the implementation potential of smart pillboxes among patients with chronic diseases, this study aimed to explore patients' acceptability to use such devices and its associated fa... |
2,334,571 | Nearly fatal ventricular arrhythmia following pacemaker implantation in a young female with complete heart block. | This case concerns a 24-year-old female who developed malignant ventricular tachyarrhythmia a few weeks after pacemaker implantation for complete heart block. Apparently, right ventricular pacing caused significant repolarization abnormalities in both native and paced rhythms with marked QT prolongation and substantial... |
2,334,572 | "A PCMH mind and a PCMH heart": Patient, faculty, and learner perspectives on collaborative care in an interprofessional team-based training programme. | <AbstractText Label="RATIONALE, AIMS, AND OBJECTIVES" NlmCategory="OBJECTIVE">Providing high-quality primary care in patient-centred medical homes (PCMHa) requires competencies that can only be provided by interprofessional (IP) education. The benefits of collaborative training have been documented for learners, but le... |
2,334,573 | Gallstone ileus managed with enterolithotomy. | Although gallstone disease is classically associated with the inflammatory sequela of cholecystitis, other presentations include gallstone ileus, Mirizzi syndrome, Bouveret syndrome and gallstone ileus. Gallstone ileus occurs when a gallstone passes from a cholecystoduodenal fistula into the gastrointestinal tract and ... |
2,334,574 | Time-Course Transcriptome Analysis for Drug Repositioning in <i>Fusobacterium nucleatum</i>-Infected Human Gingival Fibroblasts. | <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>) is a crucial periodontal pathogen and human gingival fibroblasts (GFs) are the first line of defense against oral pathogens. However, the research on potential molecular mechanisms of host defense and effective treatment of <i>F. nucleatum</i> infection in GFs remain... |
2,334,575 | The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial. | Intravenous dexmedetomidine is known to attenuate stress response in patients undergoing laparoscopic surgery. We investigated whether the addition of the highly selective alpha-2 adrenergic agonist dexmedetomidine into ropivacaine for ultrasound-guided transversus abdominis plane block could inhibit stress response du... |
2,334,576 | Efficacy of Epidural Dexamethasone Combined with Intrathecal Nalbuphine in Lower Abdominal Oncology Operations. | Dragging pain during lower abdominal surgeries under intrathecal anesthesia is a common problem. Epidural steroid seemed to be effective in reducing intra and postoperative pain. Kappa receptor agonist like nalbuphine helps in reduction of visceral pain. Hence, this study was designed to detect the efficacy of epidural... |
2,334,577 | Fascia Iliaca Block as an Anesthetic Technique for: Acute Lower Limb Ischemia. | The purpose of this study is to evaluate the efficacy of preoperative fascia iliaca block (FIB) as a sole anesthetic technique in transfemoral thromboembolectomy of unilateral acute lower limb ischemia compared to unilateral spinal anesthesia (SA) as a primary outcome. Hemodynamic variation, postoperative pain score, a... |
2,334,578 | Comparison between Position Change after Low-Dose Spinal Anesthesia and Higher dose with Sitting Position in Elderly Patients: Block Characteristics, Hemodynamic Changes, and Complications. | Large numbers of patients are presenting for surgeries with aging-related pre-existing conditions that make them at higher risks of adverse outcomes. Hemodynamic instability due to high sympathetic nerve block largely limits the use of conventional dose spinal anesthesia in high risk elderly patients.</AbstractText>We ... |
2,334,579 | Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block. | Investigating human heart development and applying this to deviations resulting in disease is incomplete without molecular characterization of the cell types required for normal functioning. We investigated foetal human heart single-cell transcriptomes from mid-gestational healthy and anti-SSA/Ro associated congenital ... |
2,334,580 | Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy. | Although saturated fatty acid (FA) (SFA) and monounsaturated FA (MUFA) are synthesized in cancer cells from acetyl-CoA, polyunsaturated FAs (PUFAs) are necessarily obtained from diet. Depending on concentrations and metabolism, these different FAs may support tumor proliferation but also exert growth inhibitory effects... |
2,334,581 | Analgesia nociception index and hemodynamic changes during skull pin application for supratentorial craniotomies in patients receiving scalp block versus pin-site infiltration: A randomized controlled trial. | Noxious stimulation such as skull pin insertion for craniotomy elicits a significant hemodynamic response. Both regional analgesic techniques (pin-site infiltration [PSI] and scalp block [SB]), and systemic strategies (opioids, alpha-2 agonists, anesthetics, and beta-blockers) have shown to attenuate this response. Ana... |
2,334,582 | A preoperative bupivacaine retrobulbar block offers superior antinociception compared with an intraoperative splash block in dogs undergoing enucleation. | Investigate nociception differences in dogs undergoing enucleation administered bupivacaine either via preoperative retrobulbar block (pRB) or intraoperative splash block (iSB).</AbstractText>Prospective, randomized, double-masked, clinical comparison study. Dogs undergoing unilateral enucleation were randomized to two... |
2,334,583 | Association of Social Jetlag With Sleep Quality and Autonomic Cardiac Control During Sleep in Young Healthy Men. | Social jetlag (SJL), the difference in sleep timing between work and free days is a consequence of the discrepancy between the individual's circadian rhythm and the social clock. SJL is considered a chronic stress factor and has been linked to various health problems. In this field study, we examined for the first time... |
2,334,584 | Adipokines disrupt cardiac differentiation and cardiomyocyte survival. | The role of adipose tissue in the pathophysiology of cardiovascular disease remains a major subject of research. The objective of the present study was to dissect the molecular mechanisms that regulate the survival and differentiation of cardiac cells in an obese environment.</AbstractText>We isolated murine/human card... |
2,334,585 | Dysregulation of Hyaluronan Homeostasis During White Matter Injury. | Although the extra cellular matrix (ECM) comprises a major proportion of the CNS parenchyma, new roles for the ECM in regeneration and repair responses to CNS injury have only recently been appreciated. The ECM undergoes extensive remodeling following injury to the developing or mature CNS in disorders that -include pe... |
2,334,586 | Two males with sick sinus syndrome in a family with 0.6 kb deletions involving major domains in MECP2. | Mutations in methyl-CpG-binding protein 2 (MECP2) in males can lead to various phenotypes, ranging from neonatal encephalopathy to intellectual disability. In this study, using Nord's method of next-generation sequencing in three siblings, we identified a 0.6 kb deletion involving the transcriptional repression ... |
2,334,587 | Superficial cervical plexus blockade improves pain control after thyroidectomy: A randomized controlled trial. | The aim was to evaluate the ability of bilateral superficial cervical plexus blockade to control pain and to reduce the side effects of general anesthesia in patients submitted to thyroidectomy.</AbstractText>In this randomized controlled trial, we prospectively studied 100 consecutive patients who underwent total thyr... |
2,334,588 | Therapeutic apheresis during pregnancy: A single center experience. | Therapeutic apheresis (TA) represents a treatment option for pre-existing conditions or diseases occurring during gestation. Although pregnancy is not a contraindication per se, due to the lack of evidence-based guidelines and presumed risk of maternal/fetal adverse events there is a general resistance to its applicati... |
2,334,589 | No effect of triheptanoin on exercise performance in McArdle disease. | To study if treatment with triheptanoin, a 7-carbon triglyceride, improves exercise tolerance in patients with McArdle disease. McArdle patients have a complete block in glycogenolysis and glycogen-dependent expansion of tricarboxylic acid cycle (TCA), which may restrict fat oxidation. We hypothesized that triheptanoin... |
2,334,590 | Use of antenatal fluorinated corticosteroids in management of congenital heart block: Systematic review and meta-analysis. | To evaluate outcomes of fluorinated corticosteroids, with or without other medications, for treatment of congenital heart block in-utero.</AbstractText>A search was conducted through MEDLINE, EMBASE, WEB OF SCIENCE and SCOPUS from inception to October 2017. Only comparative studies are considered eligible. Outcomes inc... |
2,334,591 | Cardiac Rehabilitation Availability and Density around the Globe. | Despite the epidemic of cardiovascular disease and the benefits of cardiac rehabilitation (CR), availability is known to be insufficient, although this is not quantified. This study ascertained CR availability, volumes and its drivers, and density.</AbstractText>A survey was administered to CR programs globally. Cardia... |
2,334,592 | Efficacy of Bilateral Erector Spinae Plane Block in Management of Acute Postoperative Surgical Pain After Pediatric Cardiac Surgeries Through a Midline Sternotomy. | Regional analgesia continues to evolve with the introduction of ultrasound-guided fascial plane blocks. Erector spinae plane block (ESPB) is a novel technique gaining recent acceptability as a perioperative modality of analgesia in various thoracic and abdominal surgeries. However, literature on the use of ESPB in pedi... |
2,334,593 | Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation: a pragmatic, randomised trial. | Combination nicotine replacement therapy shows additive cessation benefits. We aimed to find out the effectiveness of combining nicotine patches with an e-cigarette (with and without nicotine) on six-month smoking abstinence.</AbstractText>We did a pragmatic, three-arm, parallel-group trial in New Zealand in adult smok... |
2,334,594 | Extrapolating Survival Data Using Historical Trial-Based a Priori Distributions. | To show how clinical trial data can be extrapolated using historical trial data-based a priori distributions.</AbstractText>Extrapolations based on 30-month pivotal multiple myeloma trial data were compared with 75-month data from the same trial. The 30-month data represent a typical decision-making scenario where earl... |
2,334,595 | Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being. | The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, inc... |
2,334,596 | Impact of Specimen Characteristics on PD-L1 Testing in Non-Small Cell Lung Cancer: Validation of the IASLC PD-L1 Testing Recommendations. | Molecules targeting programmed cell death 1 or its ligand programmed death ligand 1 (PD-L1) revolutionized the treatment of patients with NSCLC. The only approved biomarker for predicting treatment response is the PD-L1 tumor proportion score (TPS) determined by immunohistochemistry. According to International Associat... |
2,334,597 | Maternal night-time eating and sleep duration in relation to length of gestation and preterm birth. | <AbstractText Label="BACKGROUND & AIMS">Maternal metabolic disturbance arising from inappropriate meal timing or sleep deprivation may disrupt circadian rhythm, potentially inducing pregnancy complications. We examined the associations of maternal night-time eating and sleep duration during pregnancy with gestation... |
2,334,598 | Comparison of hemodynamic changes of magnesium sulfate and dexmedetomidine for an axillary brachial plexus block. | Axillary brachial plexus block is used for anesthesia in hands and forearm surgery. The aim of this study was to compare the hemodynamic changes of magnesium sulfate and dexmedetomidine in axillary block.</AbstractText>This randomized, double-blind clinical trial was conducted on 99 patients undergoing a forearm and ha... |
2,334,599 | Sonotherapy in the reduction of anxiety and postoperative pain in patients with regional anesthesia as a sole technique: randomized, controlled clinical trial. | To determine if sonotherapy reduces the anxiety level and postoperative pain in adults undergoing outpatient orthopedic surgery under regional anesthesia.</AbstractText>A randomized, double-blind, placebo-controlled study in 80 adult patients undergoing orthopedic surgery, 40 received intervention with sonotherapy and ... |
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