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2,334,700 | Asystole in Orthognathic Surgery: A Case Report. | A previously healthy 26-year-old man presented for elective Le Fort I osteotomy, bilateral mandibular osteotomy, and genioplasty. During the intraoperative course, the patient developed sudden bradycardia and asystole on placement of a bite block. Asystole is an extremely rare consequence of the trigeminocardiac reflex... |
2,334,701 | Randomised controlled trial of dexmedetomidine sedation vs general anaesthesia for inguinal hernia surgery on perioperative outcomes in infants. | Neonates and infants undergoing general anaesthesia for hernia surgery are at risk of perioperative cardiorespiratory adverse events. The use of regional anaesthesia with dexmedetomidine preserves airway tone and may potentially avoid these complications. This study compares the perioperative conditions and adverse eve... |
2,334,702 | Complete Heart Block due to Octreotide Infusion in Patient with Cryptogenic Cirrhosis. | A 62-year-old man was admitted to the emergency department (ED) with the complaint of intense hematemesis. He was admitted to intensive care unit because of acute esophageal variceal hemorrhage. He underwent sclerotherapy followed by a slow infusion of intravenous octreotide. Complete heart block occured in the patient... |
2,334,703 | A case of esophagogastroduodenoscopy induced Takotsubo cardiomyopathy with complete heart block. | Takotsubo cardiomyopathy (TC) describes a reversible left ventricular dysfunction characterized by apical ballooning and basal hyperkinesis, commonly triggered by emotional or physical distress. TC associated with an esophagogastroduodenoscopy (EGD) has rarely been reported. We report a case of TC with complete heart b... |
2,334,704 | Accelerating cardiac diffusion tensor imaging combining local low-rank and 3D TV constraint. | Diffusion tensor magnetic resonance imaging (DT-MRI, or DTI) is a promising technique for invasively probing biological tissue structures. However, DTI is known to suffer from much longer acquisition time with respect to conventional MRI and the problem is worsened when dealing with in vivo acquisitions. Therefore, fas... |
2,334,705 | Is Interleukin-38 a key player cytokine in atherosclerosis immune gene therapy? | Atherosclerosis, a chronic inflammatory disease of the arteries associated with lipids and other metabolic alterations is a leading cause of death all around the world and its rate is raising as a result of unhealthy lifestyles. Reports by World Health Organization indicate that 31% of all death occurrences are due to ... |
2,334,706 | Glycerol derived process contaminants in refined coconut oil induce cholesterol synthesis in HepG2 cells. | Despite its 50-year history, the conventional diet-heart hypothesis holding that dietary saturated fats raise serum cholesterol, and with it, cardiovascular risk, remains controversial. Harsh chemical and physical treatment generates process contaminants, and refined oils raise serum and tissue cholesterol in vivo inde... |
2,334,707 | The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology. | The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology an... |
2,334,708 | The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. | FBXW7 is a tumor suppressive E3 ligase, whereas RAS-ERK and mechanistic target of rapamycin kinase (mTORC1) are two major oncogenic pathways. Whether and how FBXW7 regulates these two oncogenic pathways are unknown. Here, we showed that SHOC2, a RAS activator, is a FBXW7 substrate. Growth stimuli trigger... |
2,334,709 | Naproxen Nanoparticle-Loaded Thermosensitive Chitosan Hydrogel for Prevention of Postoperative Adhesions. | Postoperative adhesions are the most common complications of peri-abdominal surgery; they not only affect the patient's quality of life but also increase the risk of a subsequent surgery. The use of implantable dressings to physically block surgical wounds is the primary solution to prevent postoperative adhesions. In ... |
2,334,710 | Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins. | In higher eukaryotes, DNA damage repair response pathways are orchestrated by several molecular signals including ubiquitination. In particular the repair of DNA interstrand crosslinks, toxic to transcription and replication processes, involve the activation of the Fanconi anemia repair pathway. At the heart of this pa... |
2,334,711 | Acute Effects of Interrupting Prolonged Sitting With Intermittent Physical Activity on Blood Pressure in Preadolescent Children. | To compare the acute effects of intermittent physical activity (PA) across 4 different intensities on blood pressure.</AbstractText>Thirty children (12 males and 18 females; aged 7-11 y; 33% overweight/obese; 53% nonwhite) completed 4 experimental conditions in random order: 8 hours sitting interrupted with 20, 2-... |
2,334,712 | BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses. | BRD4 is a BET family protein that binds acetylated histones and regulates transcription. BET/BRD4 inhibitors block blood cancer growth and inflammation and serve as a new therapeutic strategy. However, the biological role of BRD4 in normal hematopoiesis and inflammation is not fully understood. Analysis of Brd4 conditi... |
2,334,713 | GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. | <AbstractText Label="BACKGROUND & AIMS">Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans.</... |
2,334,714 | Relationship of Neighborhood Greenness to Heart Disease in 249 405 US Medicare Beneficiaries. | Background Nature exposures may be associated with reduced risk of heart disease. The present study examines the relationship between objective measures of neighborhood greenness (vegetative presence) and 4 heart disease diagnoses (acute myocardial infarction, ischemic heart disease, heart failure, and atrial fibrillat... |
2,334,715 | Cardiovascular Risk in Middle-Aged and Older Immigrants: Exploring Residency Period and Health Insurance Coverage. | It is reported that while immigrants are, initially, healthier than the native-born upon resettlement, this advantage erodes over time. In the United States, uninsured aging immigrants are increasingly experiencing severe complications of cardiovascular disease (CVD). The purpose of this study was to compare overall CV... |
2,334,716 | Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis. | Three out of four people with diabetes will die of cardiovascular disease. However, the molecular mechanisms by which hyperglycemia promotes atherosclerosis, the major underlying cause of cardiovascular disease, are not clear.</AbstractText>Three distinct models of hyperglycemia-associated accelerated atherosclerosis w... |
2,334,717 | Real-Time Ultrasound Improves Accuracy of Caudal Block in Children. | Caudal block, the most common regional anesthetic in children, is predominantly performed using palpation to determine placement. The efficacy of the palpation technique is unknown with respect to block success. While ultrasound has been suggested for use during caudal block, its use is infrequent.</AbstractText>A sing... |
2,334,718 | Clinical comparison of two techniques of brachial plexus block for forelimb surgery in dogs. | The objective of this study was to compare two different local anaesthesia techniques for intraoperative analgesia in dogs undergoing surgical procedures distal to the mid humeral diaphysis. Thirty-two dogs were divided into two groups: the US group received an ultrasound-guided brachial plexus block at the level of th... |
2,334,719 | Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis. | Cardiac fluorodeoxyglucose positron-emission tomography (FDG-PET) has emerged as a standard imaging modality for the diagnosis of cardiac sarcoidosis (CS); however, there is a scarcity of data on the use of serial FDG-PET to guide immunosuppressive therapy. The aim of this work was to report our experience using serial... |
2,334,720 | Use of atracurium and its reversal with neostigmine in 14 pet rabbits undergoing ophthalmic surgery: a retrospective study. | The objective of this retrospective study was to report the clinical use of atracurium and its reversal with neostigmine in pet rabbits. The medical records of 14 rabbits undergoing anaesthesia for ophthalmic surgery were located through a search of the hospital's database. Demographic data and data pertaining to the u... |
2,334,721 | Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGlu <i><sub>u</sub></i> Imaging of Cortical Afferents in the Striatum of Normal and Huntington (Q175) Mice. | Changes in the balance between glutamate (Glu) release and uptake may stimulate synaptic reorganization and even synapse loss. In the case of neurodegeneration, a mismatch between astroglial Glu uptake and presynaptic Glu release could be detected if both parameters were assessed independently and at a single-synapse l... |
2,334,722 | Comparison of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery: A clinical trial. | <b>Background:</b> Given the importance of patients' pain after laparoscopic surgeries, this study was conducted to compare the effectiveness of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery. <b>Methods:</b> Patients admitted to Rasool Akram hospital w... |
2,334,723 | A Wavelet Transform-Based Neural Network Denoising Algorithm for Mobile Phonocardiography. | Cardiovascular pathologies cause 23.5% of human deaths, worldwide. An auto-diagnostic system monitoring heart activity, which can identify the early symptoms of cardiac illnesses, might reduce the death rate caused by these problems. Phonocardiography (PCG) is one of the possible techniques able to detect heart problem... |
2,334,724 | Emergency Medicine Palliative Care Access (EMPallA): protocol for a multicentre randomised controlled trial comparing the effectiveness of specialty outpatient versus nurse-led telephonic palliative care of older adults with advanced illness. | Emergency department (ED)-initiated palliative care has been shown to improve patient-centred outcomes in older adults with serious, life-limiting illnesses. However, the optimal modality for providing such interventions is unknown. This study aims to compare nurse-led telephonic case management to specialty outpatient... |
2,334,725 | Multiscale Fine-Grained Heart Rate Variability Analysis for Recognizing the Severity of Hypertension. | Hypertension is a common and chronic disease and causes severe damage to patients' health. Blood pressure of a human being is controlled by the autonomic nervous system. Heart rate variability (HRV) is an impact of the autonomic nervous system and an indicator of the balance of the cardiac sympathetic nerve and vagus n... |
2,334,726 | The heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index in pediatric surgical patients from 0 to 2 years under sevoflurane anesthesia-A prospective observational pilot study. | The heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index is a continuous noninvasive tool to assess pain and discomfort in infants <2 years. Initial studies focused on pain monitoring in the neonatal intensive care unit environment.</AbstractText>The aim of this study wa... |
2,334,727 | Persistent Postsurgical Pain Following Thoracotomy: A Comparison of Thoracic Epidural and Paravertebral Blockade as Preventive Analgesia. | Persistent postsurgical pain (PPP) is common following thoracotomy. Thoracic epidural (TEB) and paravertebral blockade (PVB) are both established forms of perioperative analgesia for thoracotomy. There is currently a lack of data on their influence on PPP; this study aims to evaluate both techniques on PPP.</AbstractTe... |
2,334,728 | PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction. | Cardiac dysfunction is a vital complication during endotoxemia (ETM). Accumulating evidence suggests that enhanced glycolytic metabolism promotes inflammatory and myocardial diseases. In this study, we performed deep mRNA sequencing analysis on the hearts of control and lipopolysaccharide (LPS)-challenged mice (40 ... |
2,334,729 | Risk factors of clinical mastitis and antimicrobial susceptibility test results of mastitis milk from dairy cattle in western Thailand: Bayesian network analysis. | Using Bayesian network analysis, this cross-sectional study aimed to identify the conditional probability among dairy farm practices, cow characteristics, bacteriological culture results, and antimicrobial susceptibility test results of milk from dairy cows with clinical mastitis in western Thailand. Data associated wi... |
2,334,730 | Revealing the structure of the associations between housing system, facilities, management and welfare of commercial laying hens using Additive Bayesian Networks. | After the ban of battery cages in 1988, a welfare control programme for laying hens was developed in Sweden. Its goal was to monitor and ensure that animal welfare was not negatively affected by the new housing systems. The present observational study provides an overview of the current welfare status of commercial lay... |
2,334,731 | Goals-of-Care Conversations for Older Adults With Serious Illness in the Emergency Department: Challenges and Opportunities. | During the last 6 months of life, 75% of older adults with preexisting serious illness, such as advanced heart failure, lung disease, and cancer, visit the emergency department (ED). ED visits often mark an inflection point in these patients' illness trajectories, signaling a more rapid rate of decline. Although most p... |
2,334,732 | Comparative evaluation of anaesthetic efficacy and haemodynamic effects of a combination of isobaric bupivacaine with buprenorphine vs. isobaric levobupivacaine with buprenorphine for spinal anaesthesia - A double blinded randomised clinical trial. | Bupivacaine is the most frequently used local anaesthetic for spinal anaesthesia, however, use of levobupivacaine in clinical practice has advanced recently. This study aimed to compare the anaesthetic potency and haemodynamic effects of intrathecal bupivacaine with buprenorphine versus levobupivacaine with buprenorphi... |
2,334,733 | Effectiveness of Augmented Reality Mobile Simulator in Teaching Local Anesthesia of Inferior Alveolar Nerve Block. | The aim of this study was to evaluate the effectiveness of a mobile augmented reality simulator for local anesthesia training with dental students who are administering inferior alveolar nerve block (IANB) for the first time. Participants in this prospective study conducted in 2016 were 41 fourth- and fifth-year studen... |
2,334,734 | Interatrial block in prediction of all-cause mortality after first-ever ischemic stroke. | Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predicted all-cause mortality during 10 years after ischemic stroke.</AbstractText>The study sample comprised ... |
2,334,735 | Supplementation of sodium butyrate to postweaned heifer diets: Effects on growth performance, nutrient digestibility, and health. | The objective of this study was to determine the effect of varying levels of sodium butyrate (SB) supplementation in feed on the growth, digestibility, and health of postweaned heifers. Forty Holstein dairy heifers with a mean age of 84 d and average body weight (BW) of 100.9 ± 11.2 kg were housed in a naturally v... |
2,334,736 | An integrated, collaborative healthcare model for the early diagnosis and management of dementia: Preliminary audit results from the first transdisciplinary service integrating family medicine and geriatric psychiatry services to the heart of patients' homes. | The number of dementia cases is expected to rise exponentially over the years in many parts of the world. Collaborative healthcare partnerships are envisaged as a solution to this problem. Primary care physicians form the vanguard of early detection of dementia and influence clinical care that these patients receive. H... |
2,334,737 | Modelling the impact of a tax on sweetened beverages in the Philippines: an extended cost-effectiveness analysis. | To assess the potential impact of a new tax on sweetened beverages on premature deaths associated with noncommunicable diseases in the Philippines.</AbstractText>In January 2018, the Philippines began imposing a tax of 6 Philippine pesos per litre (around 13%) on sweetened beverages to curb the obesity burden. Usi... |
2,334,738 | Electronic health records accurately predict renal replacement therapy in acute kidney injury. | Electronic health records (EHR) detect the onset of acute kidney injury (AKI) in hospitalized patients, and may identify those at highest risk of mortality and renal replacement therapy (RRT), for earlier targeted intervention.</AbstractText>Prospective observational study to derive prediction models for hospital morta... |
2,334,739 | The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells. | The mechanisms controlling CD4<sup>+</sup> T cell switching from an effector to an anti-inflammatory (IL-10<sup>+</sup>) phenotype play an important role in the persistence of chronic inflammatory diseases. Here, we identify the cholesterol biosynthesis pathway as a key regulator of this process. Pathway analysis of cu... |
2,334,740 | Systemic lupus erythematosus in pregnancy: high risk, high reward. | The aim of this study was to describe risks of systemic lupus erythematosus (SLE) in pregnancy and the importance of preconception counselling, medication optimization and close surveillance.</AbstractText>Advances in care for pregnant patients with SLE have led to improved obstetric outcomes, but maternal and foetal r... |
2,334,741 | Effects of Thoracic Epidural Anesthesia on Neuronal Cardiac Regulation and Cardiac Function. | Cardiac sympathetic blockade with high-thoracic epidural anesthesia is considered beneficial in patients undergoing major surgery because it offers protection in ischemic heart disease. Major outcome studies have failed to confirm such a benefit, however. In fact, there is growing concern about potential harm associate... |
2,334,742 | Sphingosine-1-phosphate attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via a mitochondrial pathway. | Our previous study showed that Sphingosine-1-phosphate (S1P) could protect cardiomyocytes against hypoxia/reoxygenation (H/R) injury via the JAK-STAT pathway and maintain normal myocardial mitochondria integrity in vivo. However, it is not known yet whether S1P can relieve mitochondrial dysfunction via the mitocho... |
2,334,743 | PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study. | Increased-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPescalated</sub>) improves progression-free survival in patients with advanced Hodgkin lymphoma compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), but is associated with increased... |
2,334,744 | A randomized-controlled, double-blind study to evaluate the efficacy of caudal midazolam, ketamine and neostigmine as adjuvants to bupivacaine on postoperative analgesic in children undergoing lower abdominal surgery. | • Background: Caudal epidural is the most commonly used technique for the management of postoperative pain in children. The aim of the present study was to assess and compare the efficacy of caudal bupivacaine as a postoperative analgesic alone or combined with midazolam, ketamine, and neostigmine in pediatric p... |
2,334,745 | Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. | Mural cells (MCs) are essential for blood vessel stability and function; however, the mechanisms that regulate MC development remain incompletely understood, in particular those involved in MC specification. Here, we investigated the first steps of MC formation in zebrafish using transgenic reporters. Using <i>pdgfrb</... |
2,334,746 | Effect of Deep Inspiration and Expiration on QTc Interval in Normal Healthy Subjects. | Background It is a well known fact that phases of respiration cause change in heart rate and autonomic tone of the heart. But how cardiovascular autonomic reflexes affect the electrocardiographic Heart rate-corrected QT interval (QTc) during the inspiratory and expiratory phase of respiration also need to be establishe... |
2,334,747 | Long noncoding RNA AK088388 regulates autophagy through miR-30a to affect cardiomyocyte injury. | Finding ways to reduce myocardial ischemia/reperfusion injury in the process of myocardial infarction has been an area of intense study in the field of heart disease. Recent studies have shown that long noncoding RNA (lncRNA) and autophagy play important roles in cardiovascular diseases. In our study, software analysis... |
2,334,748 | [Diagnosis and treatment of kidney involvement in plasma cell diseases : Renal involvement in multiple myeloma and monoclonal gammopathies]. | Kidney involvement is a common complication in patients with plasma cell diseases.</AbstractText>This article outlines the spectrum of renal involvement in plasma cell dyscrasia and describes diagnostic and therapeutic measures to guide clinical management.</AbstractText>Evaluation and discussion of the current li... |
2,334,749 | Music Interventions in Pediatric Surgery (The Music Under Surgery In Children Study): A Randomized Clinical Trial. | Perioperative music interventions have been shown to reduce anxiety and pain in adults. This inexpensive, easily applicable intervention could be of benefit to children as well. Our objective was to determine the effects of music interventions on distress, anxiety, and postoperative pain in infants undergoing surgery.<... |
2,334,750 | 8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1. | Background 8-Aminoguanosine and 8-aminoguanine are K<sup>+</sup>-sparing natriuretics that increase glucose excretion. Most effects of 8-aminoguanosine are due to its metabolism to 8-aminoguanine. However, the mechanism by which 8-aminoguanine affects renal function is unknown and is the focus of this investigation. Me... |
2,334,751 | The Effect of Family-Centered Empowerment Model on the Illness Perception in Heart Failure Patients: a Randomized Controlled Clinical Trial. | <b><i>Introduction:</i></b> Heart failure is a chronic medical condition that, despite the existing therapies, involves different aspects of an individual's life (such as self-care capability). Illness perception is one of the most important variables which seem to improve the self-efficacy skills in chronic diseases s... |
2,334,752 | Sphenopalatine ganglion block: an external gate to modulate cardiac autonomic tone and suppress premature ventricular beats? | Autonomic modulation is used for treating various cardiovascular diseases, such as cardiac arrhythmias. Sphenopalatine ganglion (SPG) block is an easy, non-invasive therapy for migraine with a potential cardiovascular impact that remains unclear. In this study, we sought to assess the effect of SPG block on cardiac aut... |
2,334,753 | Efficacy of erbium-doped yttrium aluminium garnet for achieving pre-emptive dental laser analgesia in children: A study protocol for a randomized clinical trial. | A current non-pharmacological mean for attaining painless conservative treatment is presented by laser analgesia (LA), considered as bio-photomodulation of pulp reactivity aiming reduction of nociceptive impulse formation. Currently no consensus is reached regarding a detailed protocol with laser parameter settings for... |
2,334,754 | High-Resolution Fast Ultrasound Imaging With Adaptive-Lag Filtered Delay-Multiply-and-Sum Beamforming and Multiline Acquisition. | Multiline acquisition (MLA) is a well-established method for a high-frame-rate cardiac ultrasound imaging, which is commonly used in conjunction with delay-and-sum (DAS) beamforming. The block-like artifacts that occur secondary to the use of MLA can be reduced using interpolation of the data acquired from adjacent tra... |
2,334,755 | Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report. | Mad Honey Disease is characterized by intoxication symptoms secondary to over-ingestion of grayanotoxin found in honey produced from rhododendron nectar. Cardiovascular symptoms are common, but psychiatric and neurological phenomena are rarely seen in this condition. Our case details a patient who presented with florid... |
2,334,756 | Association of Genetic Variation at <i>AQP4</i> Locus with Vascular Depression. | Despite its substantial clinical importance, specific genetic variants associated with depression have not yet been identified. We sought to identify genetic variants associated with depression by (a) focusing on a more homogenous subsample (vascular depression) and (b) applying a three-stage approach. First, we contac... |
2,334,757 | Local infiltration anaesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: A randomised controlled clinical trial. | Local infiltration anaesthesia (LIA) was introduced as an innovative analgesic procedure for enhanced recovery after primary total knee arthroplasty (TKA). However, LIA has never been compared with analgesia based on an adductor canal catheter and a single-shot sciatic nerve block.</AbstractText>To evaluate two analges... |
2,334,758 | Shedding light on the link between early life sun exposure and risk of multiple sclerosis: results from the EnvIMS Study. | Lower levels of sun exposure in childhood have been suggested to be associated with increased risk of multiple sclerosis (MS). In this paper we extend previous work, using two novel analytical strategies.</AbstractText>Data collected in the Environmental risk factors In MS (EnvIMS) study, a case-control study with MS c... |
2,334,759 | Horner's Syndrome and Upper Extremity Weakness After Quadratus Lumborum Block for Postcesarean Section Analgesia: A Case Report. | A healthy, 34-year-old primigravida at 41 weeks gestational age presented for cesarean delivery due to a category 2 fetal heart tracing remote from delivery. After completion of the surgery under epidural anesthesia, bilateral quadratus lumborum blocks were performed for postoperative pain. Approximately 4 hours later,... |
2,334,760 | Triacylglycerol Metabolism in <i>Drosophila melanogaster</i>. | Triacylglycerol (TAG) is the most important caloric source with respect to energy homeostasis in animals. In addition to its evolutionarily conserved importance as an energy source, TAG turnover is crucial to the metabolism of structural and signaling lipids. These neutral lipids are also key players in development and... |
2,334,761 | Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries. | BACKGROUND Levo-transposition of the great arteries (L-TGA) is a rare form of congenital heart disease that may go unrecognized until adulthood. Parturient women with L-TGA have a high likelihood of developing acute pulmonary edema and cardiac dysrhythmias during the peri-partum period. CASE REPORT We present the case ... |
2,334,762 | Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block. | Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has foc... |
2,334,763 | Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model. | TLR4, a member of the Toll-like receptor (TLR) family, serves as a pattern recognition receptor in the innate immune response to microbial pathogens. TLR4 also regulates the inflammatory reaction to ischemic injury in the heart. The TRIF-related adaptor molecule (TRAM) is an adapter that recruits the Toll/interleukin 1... |
2,334,764 | Role of dexamethasone in the para-vertebral block for pediatric patients undergoing aortic coarctation repair. randomized, double-blinded controlled study. | Surgery for aortic coarctation requires special care during anesthesia due to severe pain during the lateral thoracotomy incision, intraoperative hemodynamic instability and the need for large doses of intra- and postoperative analgesics and vasodilators. Additionally, the postoperative care of patients is very importa... |
2,334,765 | Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries. | To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events.</AbstractText>We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations betw... |
2,334,766 | An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure. | As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional stabilisation and improvement in heart function post MI include the delivery of biomaterial hydrogels a... |
2,334,767 | Atypical advanced interatrial blocks: Definition and electrocardiographic recognition. | The diagnosis of advanced interatrial block (A-IAB) is done by surface ECG analysis when the P-wave ≥120 ms with biphasic (±) morphology in leads II, III and aVF. In this brief communication, we advance a new concept involving atypical patterns of A-IAB due to changes about the morphology or duration... |
2,334,768 | Interethnic analyses of blood pressure loci in populations of East Asian and European descent. | Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 n... |
2,334,769 | Heart rate variability rebound following exposure to persistent and repetitive sleep restriction. | While it is well established that slow-wave sleep electroencephalography (EEG) rebounds following sleep deprivation, very little research has investigated autonomic nervous system recovery. We examined heart rate variability (HRV) and cardiovagal baroreflex sensitivity (BRS) during four blocks of repetitive sleep restr... |
2,334,770 | Slow and steady: Training induced improvements to response time consistency are due to overall slowing and minimized extremely slow responses. | Previous studies on response time intraindividual variability (RT IIV) have focused on differences between groups, ignoring the potential for modification. The current study provides a detailed analysis of RT IIV training effects across three age groups. Healthy adults (40 young [aged 18-30], 40 young-old [aged 65-74],... |
2,334,771 | Fully automated real-time PCR for EGFR testing in non-small cell lung carcinoma. | Molecular testing for mutations in the EGFR gene is commonplace for patients with non-small cell lung cancer (NSCLC). These patients are often very sick and management decisions need to be made urgently. In many cases, the results of molecular testing are needed the same day, in order to start targeted therapy and allo... |
2,334,772 | Autonomic reactivity in blood-injection-injury and snake phobia. | This research aimed to study the salivary flow and other autonomic reactions -heart rate (HR) and skin conductance response (SCR)- in blood-injection-injury (BII) phobia and snake phobia participants, under the assumption that exposure to blood-related pictures in BII phobia will provoke an increase in parasympathetic ... |
2,334,773 | Molecular characterization of the 2',5'-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis). | Virus infection induces type I interferons (IFNs) that in turn exert their pleiotropic effects through inducing a large number of interferon-stimulated genes (ISGs). The IFN-induced 2',5'-oligoadenylate synthetases (OASs) have been identified as a member of the ISGs family characterized by the ability to synthesize 2',... |
2,334,774 | Modeling a bivariate residential-workplace neighborhood effect when estimating the effect of proximity to fast-food establishments on body mass index. | Hierarchical modeling is the preferred approach of modeling neighborhood effects. When both residential and workplace neighborhoods are known, a bivariate (residential-workplace) neighborhood random effect that quantifies the extent that a neighborhood's residential and workplace effects are correlated may be modeled. ... |
2,334,775 | Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. | Treatment with bone-marrow-derived mesenchymal stromal cells (MSCs) has shown benefits in preclinical models of acute respiratory distress syndrome (ARDS). Safety has not been established for administration of MSCs in critically ill patients with ARDS. We did a phase 2a trial to assess safety after administration of MS... |
2,334,776 | An EigenECG Network Approach Based on PCANet for Personal Identification from ECG Signal. | We herein propose an EigenECG Network (EECGNet) based on the principal component analysis network (PCANet) for the personal identification of electrocardiogram (ECG) from human biosignal data. The EECGNet consists of three stages. In the first stage, ECG signals are preprocessed by normalization and spike removal. The ... |
2,334,777 | [A Super-Aged Patient with Advanced ALK-Positive NSCLC and Malignant Pericardial Effusion Causing Cardiac Tamponade]. | Here we report the case of an 88-year-old female with serious respiratory discomfort who exhibited significant heart enlargement and left pleural effusion in her chest X-ray. She developed cardiac tamponade with massive pericardial effusion, and the cytological analysis and diagnostic imaging revealed adenocarcinoma of... |
2,334,778 | Nasal allergen-neutralizing IgG<sub>4</sub> antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy. | Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG4</sub>-associated inhibitory antibodies that prevent IgE-facilitated allergen binding to B cells.</AbstractText>We sought to determine whether SCIT induces nasal allergen-specific IgG4</sub> antibodies with inhibitory activity that... |
2,334,779 | Sevoflurane versus isoflurane in shoulder arthroscopy in beach chair position in patients with prior interscalene brachial plexus block: A prospective randomised equivalency-based haemodynamic evaluation trial. | There is a paucity of literature on comparative effects of different inhalational anaesthetics in beach chair position (BCP) for shoulder arthroscopy. We aimed to investigate and compare the haemodynamic effects, anaesthetic and surgical outcomes between two inhalational agents.</AbstractText>In this randomised study, ... |
2,334,780 | Two novel, putative mechanisms of action for citalopram-induced platelet inhibition. | Citalopram, a selective serotonin reuptake inhibitor (SSRI), inhibits platelet function in vitro. We have previously shown that this action is independent of citalopram's ability to block serotonin uptake by the serotonin transporter and must therefore be mediated via distinct pharmacological mechanisms. We now report ... |
2,334,781 | The Analgesic Efficacy of Transverse Abdominis Plane Block versus Epidural Block after Caesarean Delivery: Which One Is Effective? TAP Block? Epidural Block? | TAP block has gained popularity to provide postoperative analgesia after abdominal surgery but its advantage over epidural analgesia is disputed. For lower abdominal surgeries, epidural analgesia has been the gold standard and time-tested technique for providing postoperative analgesia, but contraindications for the sa... |
2,334,782 | In-depth study of lin-28 suggests selectively conserved let-7 independent mechanism in Drosophila. | Lin-28 is a conserved RNA-binding protein that is involved in a wide range of developmental processes and pathogenesis. At the molecular level, Lin-28 blocks the maturation of let-7 and regulates translation of certain mRNA targets. In Drosophila, Lin-28 is reported to play a role in oogenesis, muscle formation, and th... |
2,334,783 | Comparison of Electrocardiographic Biomarkers for Differentiating Drug-Induced Single vs. Multiple Cardiac Ion Channel Block. | Since introduction of the International Conference on Harmonization proarrhythmia guidelines in 2005, no new marketed drugs have been associated with unacceptable risk of Torsade de Pointes. Although cardiac safety improved, these guidelines had the unintended consequence of eliminating potentially beneficial drugs fro... |
2,334,784 | Acute Effects of an Ergometer-Based Dryland Alpine Skiing Specific High Intensity Interval Training. | <b>Introduction:</b> To establish an alpine ski racing (ASR) specific dryland high intensity training protocol (HIT), we set out to analyze cardiorespiratory and metabolic responses of three ASR specific HIT modes using a ski ergometer compared with a running HIT. <b>Methods:</b> Ten healthy international FIS level sub... |
2,334,785 | The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. | Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain<sup>1,2</sup>. Here we uncover a link between these processes, id... |
2,334,786 | A multicenter REtrospective observational study of first-line treatment with PERtuzumab, trastuzumab and taxanes for advanced HER2 positive breast cancer patients. RePer Study. | We carried out a retrospective observational study of 264 HER2-positive advanced breast cancer (ABC) patients to explore the efficacy of first-line treatment with pertuzumab/trastuzumab/taxane in real-world setting. Survival data were analyzed by Kaplan Meier curves and log rank test. Median follow-up, length of pertuz... |
2,334,787 | Anemia of inflammation. | Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in patients with diseases that cause prolonged immune activation, including infection, autoimmune diseases, and cancer. More recently, the lis... |
2,334,788 | Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model. | Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations is contentious. The aim of the CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) stud... |
2,334,789 | [Clinical observation of ultrasound guided popliteal sciatic nerve combined saphenous nerve block for hallux valgus patients with metatarsophalangeal joint dislocation]. | To explore clinical effects of ultrasound guided popliteal sciatic nerve combined saphenous nerve block in patients with anterior foot orthopedics.</AbstractText>From January 2017 to October 2017, 60 hallux valgus patients with metatarsophalangeal joint dislocation were randomly divided into experimental and control gr... |
2,334,790 | Association Between CHADS<sub>2</sub> Score and the Development of Interatrial Block. | Interatrial block (IAB) is associated with a multitude of medical conditions. The aim of this retrospective study was to investigate whether CHADS<sub>2</sub> (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke) score is positively associated with the development of IAB. A to... |
2,334,791 | Pyridostigmine induced heart block requiring ICU admission. | Myasthenia gravis is an autoimmune disorder that effects an estimated 20 people per 100,000 in the USA per year. Pyridostigmine is a common drug used in the symptomatic treatment of myasthenia gravis. While generally safe and effective, a rare set of patients treated with pyridostigmine encounter cardiac conduction dis... |
2,334,792 | SNP-based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses. | Osteochondrosis is a common developmental orthopedic disease characterized by a failure of endochondral ossification. Standardbred horses are recognized as being predisposed to tarsal osteochondrosis. Prior heritability estimates for tarsal osteochondrosis in European Standardbreds and related trotting breeds have been... |
2,334,793 | Peripheral nerve block combined with general anesthesia for lower extremity amputation in hemodialysis patients: case series. | Anesthetic management of lower extremity amputation in chronic hemodialysis (HD) patients can be challenging because of their poor cardiovascular status. As previously reported, peripheral nerve block (PNB) may be beneficial in these complicated cases. We report the effects of PNB combined with general anesthesia on he... |
2,334,794 | [Severe bradycardia and asystole associated with sugammadex: case report]. | Sugamadex is a modified gamma-cyclodextrin, the first selective agent for reversal of neuromuscular blockade induced by steroidal non-depolarizing muscle relaxants, with greater affinity for rocuronium. In this article we present a case of severe bradycardia and asystole following sugammadex administration.</AbstractTe... |
2,334,795 | Clinical Performance of the DentalVibe® Injection System on Pain Perception During Local Anesthesia in Children. | <b>Purpose:</b> The purpose of this study was to clinically compare injection pain experience in children using three methods.<b>Methods:</b> This was a randomized clinical trial conducted among 150 children (81 girls, 69 boys), from seven to 14 years of age, who required operative dental treatment. Fifty patients were... |
2,334,796 | Serratus anterior plane block for minimal invasive heart surgery. | Minimal invasive heart surgery (MIHS) presents several benefits, but provides intense and prolonged post-operative pain. Our objective was to compare efficacy of serratus anterior plane block (SAPB) with continuous wound infiltration (CWI) for management of post-operative pain following MIHS.</AbstractText>It's retrosp... |
2,334,797 | Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis. | Apoptosis is associated with various myocardial diseases. Angiotensin II (Ang II) plays a central role in the pathogenesis of RAAS-triggered cardiac apoptosis. Our previous studies showed that mammalian Ste20-like kinase 1 (Mst1) aggravates cardiac dysfunction in cardiomyocyte under pathological conditions, but its rol... |
2,334,798 | [Effect of dexmedetomidine on supraclavicular brachial plexus block: a randomized double blind prospective study]. | To evaluate the effect of dexmedetomidine combined with ropivacaine on brachial plexus block in patients scheduled for elective shoulder arthroscopy.</AbstractText>Ninety patients with American Society of Anesthesiologists (ASA) I or II, scheduled for elective shoulder arthroscopy, were randomly divided into three grou... |
2,334,799 | Norepinephrine Infusion for Preventing Postspinal Anesthesia Hypotension during Cesarean Delivery: A Randomized Dose-finding Trial. | Norepinephrine has been recently introduced for prophylaxis against postspinal hypotension during cesarean delivery; however, no data are available regarding its optimum dose. The objective of this study is to compare three infusion rates of norepinephrine for prophylaxis against postspinal hypotension during cesarean ... |
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