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28,400 | Urgent clinical challenges in children with ischemic stroke: analysis of 1065 patients from the 1-800-NOCLOTS pediatric stroke telephone consultation service. | Clinical trials are lacking in pediatric stroke. As a result, physicians caring for children with stroke face significant challenges. The patient characteristics and specific nature of clinical challenges facing practicing clinicians can inform the design of and priorities for developing relevant clinical trials.</Abst... |
28,401 | Antiphospholipid antibodies and platelet activation as risk factors for thrombosis in thrombocythaemia. | Risk factors for thrombosis (TB) in thrombocythaemia (TC) associated with myeloproliferative disorder (MPD) are not well defined.</AbstractText>We measured antiphospholipid antibodies (APLA) in 35 patients with TC associated with MPD. Fourteen had TB and 21 did not. We assayed IgG and IgM APLA by ELISA for 6 antigens: ... |
28,402 | No waiting in vein. | Patients in the Wirra with a suspected DVT can now be diagnosed and treated in a nurse-led centre. The service has reduced waiting times and unnecessary hospital admissions. The service is a collaboration between two primary care trusts and Wirral Hospital NHS Trust. Patients can be referred directly to the walk-in cen... |
28,403 | [Mutations of genes associated with thromboses in ischemic stroke in patients with primary antiphospholipid syndrome]. | To study factor V Leiden, prothrombin (G1691A), 5, 10-methylenetetrahydrofolate reductase (MTHFR, C677T) mutations in patients with primary antiphospholipid syndrome (PAPS) and cerebrovascular disease (CVD).</AbstractText>We studied 44 patients (38 female, 6 male, mean age 41.6 +/- 11.6 years) with PAPS and CVD. Detect... |
28,404 | Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic events. | To assess platelet function under defined flow conditions in patients with antiphospholipid syndrome (APS) and to correlate the results with thrombotic complications and the presence of subsets of antiphospholipid antibodies (aPL), lupus anticoagulant (LAC), and/or anticardiolipin antibodies (aCL).</AbstractText>We stu... |
28,405 | Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus? | To examine autoantibody clusters and their associations with clinical features and organ damage accrual in patients with systemic lupus erythematosus (SLE).</AbstractText>The study group comprised 1,357 consecutive patients with SLE who were recruited to participate in a prospective longitudinal cohort study. In the co... |
28,406 | Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. | In transsexual people, cross-sex hormone therapy is an important component of medical treatment. In male-to-female transsexuals, feminizing effects should be achieved before irreversible sex reassignment surgery (SRS) is considered. The most common treatment regimen in male-to-female transsexuals is a combination of et... |
28,407 | [Use of antithrombotic agents in pregnant women]. | Recommendations of the American College of Chest Physicians (ACCP) concerning antithrombotic treatments were published in September 2004 and discussed in a meeting organized in Paris in November 2004 by a group of experts including a group of authors of the recommendations and French doctors specialized in these subjec... |
28,408 | Molecular genetic testing of polymorphisms associated with venous thrombosis: a review of molecular technologies. | The growing knowledge of genetic polymorphisms predisposing to venous thrombosis has increased the demand for genetic testing of associated risk factors. This has prompted the need for simple, fast, reliable, and cost-effective genotyping methods for identification of those mutations. In the past decade, a large variet... |
28,409 | The Jonas study: evaluation of the retrievability of the Cordis OptEase inferior vena cava filter. | To evaluate the success, safety, and efficacy of the retrieval of the OptEase Permanent/Retrievable Vena Cava Filter (Cordis, Warren, NJ), when implanted for temporary protection against venous thromboembolism.</AbstractText>This prospective, multicenter, non-randomized study enrolled 27 patients who needed temporary p... |
28,410 | Venous thrombosis in an ALS population over four years. | We conducted a retrospective chart review of all ALS patients seen at our institution over four years to determine the incidence of venous thromboembolism and to identify risk factors in this population. Events occurred in 13 of 438 patients (2.97%), yielding an annual incidence rate of 33.1 events per 1,000 patients (... |
28,411 | [Current status of radial optic neurotomy in the treatment of central retinal vein occlusion].<Pagination><StartPage>1053</StartPage><EndPage>1056</EndPage><MedlinePgn>1053-6</MedlinePgn></Pagination><Abstract><AbstractText>There is no definitely proven effective managements of central retinal vein occlusion to date. M... | There is no definitely proven effective managements of central retinal vein occlusion to date. Much attention has been paid for radial optic neurotomy, although it is not accepted widely as a regular surgery, the improvement of fundus appearance was observed in some cases after surgery indeed. In this paper, we reviewe... |
28,412 | Design of the Dialysis Access Consortium (DAC) Clopidogrel Prevention of Early AV Fistula Thrombosis Trial. | The Dialysis Access Consortium (DAC) was developed to investigate interventions to improve hemodialysis vascular access outcomes. The autogenous arteriovenous fistula created by direct connection of native artery to vein is the recommended vascular access for hemodialysis. However, it fails frequently due to clotting a... |
28,413 | Design of the Dialysis Access Consortium (DAC) Aggrenox Prevention Of Access Stenosis Trial. | Surgically created arteriovenous (AV) grafts are the most common type of hemodialysis vascular access in the United States, but fail frequently due to the development of venous stenosis. The Dialysis Access Consortium (DAC) Aggrenox Prevention of Access Stenosis Trial tests the hypothesis that Aggrenox (containing dipy... |
28,414 | Transarterial chemoembolization in a patient with recurrent hepatocellular carcinoma and portal vein thrombosis: a case report and review of the literature. | Primary hepatocellular carcinoma (HCC) accounts for more than 5% of all cancers in the world, and causes between 250,000 and one million deaths globally each year. The incidence of portal vein thrombosis in HCC patients is around 8%. These patients are regarded as unsuitable for chemoembolization, especially if there i... |
28,415 | Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial. | Cancer patients receiving chemotherapy experience thromboembolic complications associated with the use of long-term indwelling central venous catheters (CVCs). This prospective, double-blind, placebo-controlled, multicenter study evaluated whether prophylactic treatment with a low molecular weight heparin could prevent... |
28,416 | Pharmacological characterization of the active synthetic factor Xa inhibitors M55551 and M55165. | Factor Xa plays an important role in blood coagulation and is widely regarded as an attractive target for antithrombotic drug development. M55551 and M55165 (1-arylsulfonyl-3-piperazinone derivatives) are novel synthetic factor Xa inhibitors. In vitro, M55551 and M55165 competitively inhibited factor Xa with K(i) value... |
28,417 | Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts. | We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and migration of these cells is greatest within the first two weeks following graft placement, resulting in increased matrix metalloproteinase-2 (MMP-2) activit... |
28,418 | Outcomes of tunneled femoral hemodialysis catheters: comparison with internal jugular vein catheters. | Tunneled femoral vein dialysis catheters are used as a last resort when all other options for a permanent vascular access or thoracic central vein catheter have been exhausted. There is little published literature on the complications or outcomes of tunneled femoral catheters.</AbstractText>Using a prospective, compute... |
28,419 | Molecular diagnostics of inherited thrombosis. | Thrombophilia can best be defined as a disorder of coagulation that contributes to a predisposition towards thrombosis. Although the term thrombophilia has been used to describe arterial thrombosis, its most common usage has been in reference to venous thromboembolism (VTE). Thrombophilia can be a consequence of both a... |
28,420 | Warfarin induction at 5 mg daily is safe with a low risk of anticoagulant overdose: results of an audit of patients with deep vein thrombosis commencing warfarin. | Conventionally warfarin therapy is initiated using a loading dose given over several days. Daily international normalised ratio (INR) monitoring is recommended to prevent overdose; however, with a large proportion of patients with deep vein thrombosis now receiving treatment out of hospital daily blood tests are inconv... |
28,421 | Heparin-induced thrombocytopenia from venous thromboembolism treatment. | We aimed to characterize the clinical experiences of patients in whom heparin-induced thrombocytopenia (HIT) complicated heparin therapy for venous thromboembolism (VTE) and who switched to argatroban.</AbstractText>A retrospective analysis of previously reported prospective, multicentre, historical-controlled Argatrob... |
28,422 | Thrombolytic therapy in acute pulmonary embolism due to heparin-induced thrombocytopenia type II. | Hospitalized patients are in danger of deep venous thrombosis either due to a genetic tendency, immobilization or the underlying medical condition. Paradoxically heparin, the substance used to prevent this complication, can lead to thrombo-embolic phenomena, which can be life threatening. We report a case of heparin-in... |
28,423 | Transient global amnesia heralding basilar artery thrombosis. | The cause of transient global amnesia (TGA) remains controversial. Focal cerebral ischemia, seizure, venous congestion, and migraine have all been proposed as underlying mechanisms. We describe a patient presenting with typical TGA who two days later developed a posterior circulation stroke due to basilar artery occlus... |
28,424 | Alexia without agraphia following cerebral venous thrombosis associated with protein C and protein S deficiency. | A 26-year-old right handed female was admitted to hospital with right homonymous hemianopia associated with alexia without agraphia. Her cranial magnetic resonance imaging and magnetic resonance angiography revealed a left occipital venous infarction due to thrombosis of the left transverse, sigmoid sinuses and the lef... |
28,425 | The effect of heparin in peripheral intravenous nutrition via a fine-bore midline: a randomised double-blind controlled trial. | Peripheral intravenous nutrition (PIVN) delivered via a finebore midline offers a viable alternative to central venous feeding. The major complication is the onset of peripheral vein thrombophlebitis (PVT). Feed additives such as heparin and hydrocortisone have been advocated in its prevention. Concern over the safety ... |
28,426 | Clinically important venous thromboembolism in pediatric critical care: a Canadian survey. | Pediatric venous thromboembolism (VTE) is becoming an increasingly recognized morbidity associated with critical illness. The objective of this survey is to identify the patient factors and radiological features that pediatric intensivists consider more or less likely to make a venous thrombosis (VTE) clinically import... |
28,427 | Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study. | There is no randomized trial comparing low-molecular weight heparin (LMWH) and unfractionated heparin (UFH) for thromboprophylaxis in medical-surgical ICU patients. The primary objective of this randomized pilot study on LMWH vs UFH was to assess the feasibility of conducting a large randomized trial with respect to ti... |
28,428 | Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency. | Thromboprophylaxis with low-molecular-weight heparin (LMWH) may be more effective than unfractionated heparin but also more likely to bioaccumulate and potentially cause bleeding in patients with renal insufficiency. The objectives of this study were to assess, among medical-surgical patients in the intensive care unit... |
28,429 | Thromboprophylaxis for intensive care patients in Australia and New Zealand: a brief survey report. | Internationally, there is practice variation concerning optimal thromboprophylaxis for patients in the intensive care unit (ICU). The current practice in Australia and New Zealand is unknown.</AbstractText>We conducted a self-administered e-mail survey of 22 Australian and New Zealand ICUs expressing interest in partic... |
28,430 | Burden of illness in venous thromboembolism in critical care: a multicenter observational study. | The frequency of clinically diagnosed venous thromboembolism (VTE) including deep venous thrombosis (DVT) and pulmonary embolism (PE) in medical-surgical critically ill patients is unclear. The objectives of this study were to estimate the prevalence and incidence of radiologically confirmed DVT and PE in medical-surgi... |
28,431 | Deep venous thrombosis: clinically silent in the intensive care unit. | The reliability of clinical signs and the physical examination in the evaluation of deep venous thrombosis (DVT) in the critically ill is unknown. The purpose of this study was to determine the diagnostic properties of clinical examination for signs of DVT in a cohort of medical-surgical intensive care unit (ICU) patie... |
28,432 | Anticoagulant prophylaxis in special populations with an indwelling epidural catheter or renal insufficiency. | The prevention of deep venous thrombosis in postoperative patients who have an indwelling epidural catheter and patients with impaired renal function is a frequently encountered and challenging clinical management problem. Such patients make up a considerable proportion of patients in a medical-surgical intensive care ... |
28,433 | The modified Lapidus procedure for hallux valgus: a clinical and radiographic analysis. | Historically, the modified Lapidus procedure has been considered technically challenging, with high rates of complications, including nonunion and malunion. The purpose of this study was to review the clinical and radiographic results of this technique for the treatment of hallux valgus associated with first ray hyperm... |
28,434 | Catheter-directed thrombolysis and/or thrombectomy with selective endovascular stenting as alternatives to systemic anticoagulation for treatment of acute deep vein thrombosis. | To evaluate thrombolysis and/or thrombectomy and selective endovascular stent placement in treating acute deep vein thrombosis (DVT).</AbstractText>During a 5-year period, 28 patients were treated with catheter-directed thrombolytics and/or thrombectomy with endovascular stent placement. Seventy-two percent (n = 20) of... |
28,435 | Are temporary inferior vena cava filters really temporary? | Despite significant risk for venous thromboembolism, severely injured trauma patients often are not candidates for prophylaxis or treatment with anticoagulation. Long-term inferior vena cava (IVC) filters are associated with increased risk of postphlebitic syndrome. Retrievable IVC filters potentially offer a better so... |
28,436 | Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the PROTECT Trial. | Patients with stroke are at substantial risk of thromboembolic complications and therefore require antithrombotic prophylaxis. To show the noninferiority of the low-molecular-weight heparin certoparin to unfractionated heparin (UFH) for the prevention of thromboembolic complications, we performed a randomized, double-b... |
28,437 | Twenty-five years of advances in vascular access: bridging research to clinical practice. | Vascular access has become a key component for a multitude of IV therapies, including parenteral nutrition. Access of the central venous system has been long recognized for its associated complications of infection, thrombosis, and occlusion. Over the past 25 years, clinical practice based on research and innovation ha... |
28,438 | Surgical revision after percutaneous mitral valve repair with a clip: initial multicenter experience. | Almost 50,000 mitral valve operations are performed annually in the United States, with an increasing number of repairs. Recently, a percutaneous mitral valve repair option that achieves edge-to-edge approximation with a clip has been described in patients with mitral regurgitation.</AbstractText>We describe 6 patients... |
28,439 | Direct thrombin inhibitors for treatment of heparin induced thrombocytopenia, deep vein thrombosis and atrial fibrillation. | Thrombin is a central enzyme in hemostasis, exerting potent procoagulant effects and activating platelets. Recently, several small molecule direct thrombin inhibitors (DTI's) with important clinical applications have been developed. Both lepirudin and argatroban are effective in treatment of heparin-induced thrombocyto... |
28,440 | Direct thrombin inhibitors for the prevention of venous thromboembolism after major orthopaedic surgery. | Unfractionated heparin, low-molecular-weight heparins and vitamin K antagonists are established antithrombotic agents, but all have a number of limitations. Unfractionated heparin requires parenteral administration, has a short half-life and variable dose-response relationship. Low molecular weight heparins are more ef... |
28,441 | [Thromboprophylaxis in general surgical practices in the year 2004: perioperative use during hospitalisation, during out-patient care and following plaster cast immobilisation]. | To determine which thromboprophylactic modalities were used by general surgeons in the Netherlands; to check current clinical practice against national and international guidelines.</AbstractText>Descriptive.</AbstractText>In April 2004 a questionnaire was sent to all 106 surgical practices in the Netherlands with ques... |
28,442 | [Perioperative thromboprophylaxis--for the immobilisation period, potential extension beyond hospitalisation]. | Antithrombotic prophylaxis of venous thromboembolism after surgery, usually by means of subcutaneous administration of(low-molecular-weight) heparin, drastically reduces the incidence of postoperative thrombosis and pulmonary embolism. Therefore, this intervention is advocated in various national and international guid... |
28,443 | [Type I antithrombin deficiency as a cause of arterial and venous thrombosis in a family with severe thrombophilia].<Pagination><StartPage>2121</StartPage><EndPage>2125</EndPage><MedlinePgn>2121-5</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">In rare cases of thromboembo... | The antiphospholipid syndrome is an antibody-mediated hypercoagulable state characterized by recurrent venous and arterial thromboembolic events. Several studies have determined that the frequency of antiphospholipid syndrome in patients presenting with a venous thromboembolic event is between 4% and 14%. Because of th... |
28,444 | Delays in diagnosis of deep vein thrombosis and pulmonary embolism. | To investigate delays in the diagnosis of deep vein thrombosis (DVT) and pulmonary embolism (PE).</AbstractText>We prospectively identified 1,152 patients in whom DVT or PE had been diagnosed at 70 North American medical centers. We recorded demographic characteristics and dates of symptom onset, initial medical evalua... |
28,445 | Identifying orthopedic patients at high risk for venous thromboembolism despite thromboprophylaxis. | To evaluate risk factors for venous thromboembolism (VTE) despite thromboprophylaxis in major orthopedic surgery patients at a tertiary care hospital.</AbstractText>Charts from consecutive patients who underwent total hip replacement (THR), total knee replacement (TKR), or hip fracture surgery (HFS) [hip pinning or hem... |
28,446 | Is true FISP imaging reliable in the evaluation of venous thrombosis? | The objective of our study was to evaluate the accuracy of true fast imaging with steady-state precession (FISP) in the diagnosis of venous thrombosis using gadolinium-enhanced 3D T1-weighted gradient-echo images and correlative imaging as the gold standard.</AbstractText>Twenty-five MR examinations were retrospectivel... |
28,447 | Retinal vein occlusion, homocysteine, and methylene tetrahydrofolate reductase genotype. | The aim of this case-control study was to investigate the relationship between homocysteine (tHcy), 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T genotype, folate and vitamin B12 status, and retinal vein occlusion (RVO).</AbstractText>Subjects with RVO (n = 106) were recruited from outpatient and inpatient so... |
28,448 | Circadian fluctuations of macular edema in patients with morning vision blurring: correlation with arterial pressure and effect of light deprivation. | This study explored the causes of vision fluctuations in patients with chronic macular edema.</AbstractText>Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after awakenin... |
28,449 | Prevention of bleeding after islet transplantation: lessons learned from a multivariate analysis of 132 cases at a single institution. | Islet transplantation is being offered increasingly for selected patients with unstable type 1 diabetes. Percutaneous transhepatic portal access avoids a need for surgery, but is associated with potential risk of bleeding. Between 1999 and 2005, we performed 132 percutaneous transhepatic islet transplants in 67 patient... |
28,450 | Select utilization of obese donors in living donor liver transplantation: implications for the donor pool. | Living donor liver transplantation evolved in response to donor shortage. Current guidelines recommend potential living donors (LD) have a body mass index (BMI) <30. With the current obesity epidemic, locating nonobese LD is difficult. From September 1999 to August 2003, 68 LD with normal liver function test (LFTs) ... |
28,451 | Endovascular treatment of spinal arteriovenous fistula in a young child with hereditary hemorrhagic telangiectasia. Case report. | Hereditary hemorrhagic telangiectasia ([HHT] or Osler-Weber-Rendu syndrome) can manifest as sudden onset of epistaxis or neurological deficit in a child with characteristic mucocutaneous telangiectasias or as an asymptomatic bruit with or without overlying cutaneous vascular lesions. The authors present a case study of... |
28,452 | Disseminated staphylococcal disease: report of one case. | Childhood septic arthritis is not only an uncommon presentation with polyarticular involvement, but is also rarely complicated with thromboembolism. We report a case of a 10-year-old boy who suffered multiple staphylococcal arthritis, deep vein thrombosis, pulmonary embolism, pericardial effusion and occlusion of the a... |
28,453 | Cerebral deep venous thrombosis: case report and literature review. | The case of a 28 years old woman presenting with headache, drowsiness and vomiting of a short duration, is presented. She was diagnosed as deep cerebral venous thrombosis on the basis of MRI findings. Treatment with heparin gave completed recovery. |
28,454 | Fibrolamellar hepatocellular carcinoma in a 65-year-old woman: CT features. | A 65-year old woman with recurrent deep vein thrombosis underwent a CT scan of the upper abdomen for detection of underlying malignancy. A fibrolamellar hepatocellular carcinoma with extrahepatic subdiaphragmatic satellite lesion was found. This uncommon tumor has distinct clinical, pathological, radiological and progn... |
28,455 | D-dimer testing in ischemic stroke and cerebral sinus and venous thrombosis. | D-dimer measurement is commonly included in the diagnostic workup of patients with suspected acute symptomatic deep venous thrombosis and pulmonary embolism. As a haemostatic marker, it could be theoretically useful in other thromboembolic disorders, such as acute cerebrovascular events. In this review we summarize pub... |
28,456 | D-dimer testing in pregnancy. | Normal pregnancy is associated with alterations of the hemostatic system toward a hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation, such as D-dimer, indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. Testing for D-dim... |
28,457 | D-dimer levels, constitutional thrombophilia, and venous thrombosis prediction: clinical aspects and implications. | The negative predictive value of D-dimers in the diagnosis of a recent venous thromboembolism (VTE) episode is well established. The plasma level of D-dimer is usually increased in hypercoagulable states. The measurement of D-dimer could be of clinical interest in patients with constitutional thrombophilia as there is ... |
28,458 | D-dimer, oral anticoagulation, and venous thromboembolism recurrence. | Venous thromboembolism (VTE) requires prolonged treatment to prevent late recurrences. However, the optimal duration of vitamin K antagonist (VKA) therapy is still controversial. More recently, D-dimer (D-d) has emerged as a predictive factor for recurrences. D-d has been evaluated both during and after VKA treatment. ... |
28,459 | Screening for deep vein thrombosis and pulmonary embolism in outpatients with suspected DVT or PE by the sequential use of clinical score: a sensitive quantitative D-dimer test and noninvasive diagnostic tools. | The requirement for a safe diagnostic strategy should be based on an overall posttest incidence of venous thromboembolism (VTE) of less than 1% during 3-month follow-up. The negative predictive value (NPV) during 3 months of follow-up is 98.1 to 99% after a normal venogram, 97 to 98% after a normal compression ultrason... |
28,460 | The role of qualitative D-dimer assays, clinical probability, and noninvasive imaging tests for the diagnosis of deep vein thrombosis and pulmonary embolism. | Recent advances in the management of patients with suspected venous thromboembolism have both improved diagnostic accuracy as well as made management algorithms safer and more accessible. It is now clear that determination of clinical probability prior to diagnostic testing will improve patient management. D-dimer test... |
28,461 | Comparability of D-dimer assays in clinical samples. | D-dimers (DD) have shown sufficient proof of their efficiency in the last 10 years to play an important role in hemostasis laboratories for excluding thromboembolic events. Numerous reagents are available on the market but their performances differ. This overview takes stock of the methods used to evaluate the performa... |
28,462 | The harmonization of quantitative test results of different D-dimer methods. | Nowadays D-dimer testing is frequently applied in the diagnosis of venous thromboembolism. However, the test results of different quantitative D-dimer tests can differ significantly. The background of this variability, which is mainly caused by the variety of fibrin degradation products in plasma, the specificity of D-... |
28,463 | [Surgical treatment of chronic thromboembolic pulmonary hypertension]. | Chronic thromboembolic pulmonary hypertension is a condition that has long remained in the shadows, a kind of orphan disease, because of the lack of any curative treatment. The renewal of interest by pulmonary specialists, cardiologists and thoracic surgeon is due to the development over the past 20 years of major new ... |
28,464 | [Treatment of venous thromboembolic disease]. | Adequate initial anticoagulant treatment is required to prevent thrombus growth and recurrence. Intravenous unfractionated heparin is being replaced by low-molecular-weight heparin as the anticoagulant of choice for initial treatment of venous thromboembolism. Vitamin K antagonists remain the only oral anticoagulant av... |
28,465 | [Diagnostic approach to venous thromboembolic disease]. | The diagnosis of pulmonary embolism (PE) and deep venous thrombosis (DVT) has long been based on purely clinical grounds. Pulmonary angiography and scintigraphy, as well as venography, reveal the poor diagnostic value of signs and symptoms of PE and DVT, which are now reduced to the role of triggers for these diagnosti... |
28,466 | Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration. | Oral estrogen increases the risk of venous thromboembolism (VTE) in postmenopausal women, particularly in those with a prothrombotic mutation. Transdermal estrogen may be safe with respect to VTE. We investigated the impact of the route of estrogen administration on the association between a prothrombotic mutation (fac... |
28,467 | The use of central neuraxial techniques in parturients with factor V leiden mutation. | The factor V Leiden (FVL) mutation is a leading cause of thrombosis, particularly during pregnancy. During pregnancy, women with thrombotic disorders including FVL are often considered candidates for antepartum anticoagulation with low molecular weight heparin. Pregnancy complications related to thrombosis and the unpr... |
28,468 | Aprotinin in major orthopedic surgery: a systematic review of randomized controlled trials. | Aprotinin therapy is a promising strategy for reducing blood loss and blood transfusion requirements. The efficacy and safety of aprotinin in orthopedic surgery, however, remain controversial. We searched electronic databases for randomized controlled trials on the efficacy and safety of the use of aprotinin in orthope... |
28,469 | Effect of a clinical pharmacy education program on improvement in the quantity and quality of venous thromboembolism prophylaxis for medically ill patients. | The American College of Chest Physicians (ACCP) recommends unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) for prevention of venous thromboembolism (VTE) in medically ill patients. Despite these recommendations, a previous analysis at our institution revealed a low utilization of VTE prophylaxis in ... |
28,470 | Fine-needle aspiration cytology of epithelioid angiosarcoma: a diagnostic dilemma. | A 28-year-old woman with a 2-yr history of unilateral chronic leg swelling, initially thought to be secondary to deep vein thrombosis, later thought to be due to congenital venous malformation, eventually developed a pelvic mass, which was biopsied by fine-needle aspiration. On the basis of cytologic features on smears... |
28,471 | [Clinical analysis of mesenteric venous thrombosis:a report of 23 cases]. | To assess the early clinical diagnosis and treatment of mesenteric venous thrombosis (MVT).</AbstractText>Clinical data of 23 cases with MVT from January 1994 to December 2003 were analyzed retrospectively.</AbstractText>There were 17 males and 6 females, the age ranged from 19 to 74 years old with a mean age of 42 yea... |
28,472 | Deep vein thrombosis and pulmonary embolism in an ambulatory chronic stroke patient. | Deep vein thrombosis (DVT) is a well-known complication of stroke and frequently develops in acute stroke patients. Immobility in stroke patients increases the risk of DVT and pulmonary embolism (PE). The incidence of DVT in non-ambulatory stroke patients is more frequent than the incidence in ambulatory stroke patient... |
28,473 | Follow-up experience using histidine-tryptophan ketoglutarate solution in clinical pancreas transplantation. | In May 2003, at Indiana University, the standard cold preservation solution University of Wisconsin (UW) solution was replaced by histidine-tryptophan ketogluatarate (HTK) solution. Earlier, we presented our initial experience with HTK in pancreas preservation with an analysis of the first 10 pancreas transplants. Here... |
28,474 | [Severe hyperhomocysteinemia revealing homocystinuria in two young adults with mild phenotype]. | To the request of total plasma homocysteine determination in the investigation of vascular disease, diagnosis of homocystinuria in young adult patients with mild phenotype is not so rare.</AbstractText>A 26-year-old man developed embolic cerebral infarction and a 22-year-old woman presented a right renal venous thrombo... |
28,475 | Radiological intervention to maintain vascular access. | Stenoses and thromboses of dialysis grafts and fistulae are common problems in patients with end stage renal disease (ESRD). Timely recognition and treatment of access-related complications are essential to achieve long-term access function. Minimally invasive percutaneous interventions are techniques of growing import... |
28,476 | The use of autologous rectus facia sheath for replacement of inferior caval vein defect in orthotopic liver transplantation. | Occasionally, during liver transplantation, vascular reconstructions have to be performed. Donor vessels can be harvested for this purpose. However, when these are lacking, alternatives should be available. A possible alternative can be the use of autologous rectus fascia sheath, folded as a tube with the mesothelium o... |
28,477 | The Western Australian Audit of Surgical Mortality: advancing surgical accountability. | To describe the peer review process of the Western Australian Audit of Surgical Mortality (WAASM), selected outcomes and recommendations.</AbstractText>Prospective audit using peer review of all cases of patients who died while under the care of a Western Australian surgeon between 1 January 2002 and 30 June 2004. Audi... |
28,478 | [Thrombophilia and thrombosis]. | Generally speaking, thrombophilia includes all congenital and acquired conditions associated with increased susceptibility to thrombosis. An impaired balance between stimulating and inhibitory components of the hemostasis system may result in thrombosis or hemorrhage (extreme disorders), while moderately impaired hemos... |
28,479 | Budd-Chiari syndrome--a case report. | A 21year old male presented with abdominal pain for 2 months and abdominal distension and swelling of lower limbs for 1 month. Ultrasonography of abdomen showing coarse echotexture of liver and intraluminal filling defect of inferior vena cava (IVC) and CT scan confirming the USG finding and showing enlarged caudate lo... |
28,480 | Antithrombin III assay using thrombin in disseminated intravascular coagulation (DIC), other thromboembolic disorders and hepatic diseases. | Fifty cases comprising 11 cases of disseminated intravascular coagulation (DIC), 16 cases of venous thromboses and 23 cases of hepatic diseases were studied for AT III levels using clotting assay. Twelve samples were subjected to ATIII estimation by the commercially available synthetic chromogenic assay. Twenty age and... |
28,481 | Antiphospholipid antibodies--our experience. | Antiphospholipid antibodies (APA) have aroused multispeciality interests. In our study of 200 cases worked up for APA, we have used a few simple coagulation tests to detect lupus anticoagulant (LA) and ELISA to detect anticardiolipin antibodies. The positivity rate for LA among cases with recurrent pregnancy loss was 4... |
28,482 | Preexisting antibodies to platelet factor 4-heparin complexes in patients with acute coronary syndrome who have no history of heparin exposure. | Preexisting heparin-induced thrombocytopenia (HIT) antibodies are detected in some patients who have not previously been exposed to any kind of heparin. However, the role of preexisting HIT antibodies in acute coronary syndrome (ACS) is still unknown. This study was carried out to clarify the role of preexisting HIT an... |
28,483 | Long-term prospective study of recurrent venous thromboembolism in patients younger than 50 years. | Long-term incidence of recurrent venous thromboembolism (VTE) in patients younger than 50 years, not affected by a malignancy or chronic diseases, are poorly characterized. After the initial episode of VTE and cessation of oral anticoagulation, 98 patients, mean age 32.2+/-9.2 years were followed for a median of 117 mo... |
28,484 | Platelet activation markers in patients with venous thromboembolism without predisposing factors. | A constant in vitro hypersensitivity of platelets (adenosine diphosphate) has been suggested as a risk factor for arterial and even venous thrombosis. Our aim was to determine phenotypic and functional alterations of platelets by flow cytometry as potential prothrombotic risk factors in patients with a history of unexp... |
28,485 | Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. | We report a case of severe iron deficiency anemia with marked thrombocytosis that was complicated by central retinal vein occlusion. Platelet count was over one million per microliter and an increased number of megakaryocytes was observed in the bone marrow at the time of diagnosis of iron deficiency anemia, features t... |
28,486 | [Celiac disease, cerebral venous thrombosis and protein S deficiency, a fortuitous association?]. | Celiac disease is a pathology which is rarely associated with thrombosis complications. Cerebral vascular thrombosis has never been described in patients with a celiac disease.</AbstractText>We report an observation of a 21-year-old girl with a history of celiac disease who was hospitalized in the intensive care unit f... |
28,487 | [Optimizing history taking for evaluating the risk of venous thromboembolism: the OPTIMEV study]. | Venous thromboembolism (VTE) is a frequent disease and remains a major cause of mortality and morbidity among our patients. During the 20 past years, clinical description, diagnostic tools, and treatment have changed dramatically. Most published data describing risk factors for VTE no longer apply to the patients seen ... |
28,488 | Toremifene: an evaluation of its safety profile. | Toremifene has been in clinical use for 8 years for the treatment of advanced hormone-sensitive breast cancer and the adjuvant treatment of early breast cancer. More than 350,000 patient treatment years have accumulated, sufficient to allow evaluation of its longer-term safety profile in comparison with tamoxifen and, ... |
28,489 | Endoluminal recanalization in a patient with phlegmasia cerulea dolens using a multimodality approach. | Phlegmasia cerulea dolens, a rare complication of deep venous thrombosis, has traditionally been difficult to treat. The patient described in this report posed additional therapeutic challenges based on a history of heparin-induced thrombocytopenia. She presented with severe leg pain and swelling, and a venogram showed... |
28,490 | Utility of basilic vein transposition for dialysis access. | Autologous arteriovenous access is the key to long-term success with hemodialysis and is strongly supported by the National Kidney Foundation's Dialysis Outcomes Quality Initiative guidelines. Basilic vein transposition (BVT) fulfills the need for a durable conduit with high patency and maturation rates. This retrospec... |
28,491 | PPS-PEG surface coating to reduce thrombogenicity of small diameter ePTFE vascular grafts. | Patency failure of small vascular synthetic grafts is still a major problem for coronary and peripheral revascularization. Thus, three new surface coatings of small synthetic grafts were tested in an acute pig model to evaluate their thrombogenicity (extracorporeal arterio-venous shunt) and in a chronic rat model to ev... |
28,492 | [Diagnostics and management of central venous line infections in pediatric cancer patients]. | Otherwise unexplained clinical signs of infection in patients with tunneled or totally implanted central venous access devices (CVAD) are highly suspicious of an underlying CVAD-associated infection. Diagnostic methods include catheter swabs, blood cultures and cultures of the catheter tip or port reservoir. In case of... |
28,493 | Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. | Initial findings from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (P-1) demonstrated that tamoxifen reduced the risk of estrogen receptor-positive tumors and osteoporotic fractures in women at increased risk for breast cancer. Side effects of varying clinical significance were... |
28,494 | Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. | The risk for venous thromboembolism during pregnancy or postpartum is uncertain.</AbstractText>To estimate the relative and absolute risk for deep venous thrombosis and pulmonary embolism during pregnancy and postpartum and to describe trends in incidence.</AbstractText>Population-based inception cohort study using the... |
28,495 | The relationship between ambulation ability before surgery and the D-dimer value after total hip arthroplasty: the evaluation of ambulation ability by the timed "Up & Go" test. | We examined whether ambulatory ability before surgery might influence the post-operative D-dimer level after total hip arthroplasty (THA). One hundred two patients with hip osteoarthritis receiving THA were included in the current study. The patients were all female, and their ages ranged from 45 to 81 (average 65.0 +-... |
28,496 | Weakness in the ICU: Guillain-Barré syndrome, myasthenia gravis, and critical illness polyneuropathy/myopathy. | Weakness in the ICU may be caused by a number of disorders. Guillain-Barré syndrome (GBS) and myasthenia gravis (MG) are examples of conditions that might lead to an ICU admission. The most likely cause of weakness after ICU admission is critical illness polyneuropathy/myopathy (CIP/M).</AbstractText>Studies have ... |
28,497 | The role of a second isolated retinal artery in branch retinal vein obstruction. | To evaluate the prevalence of a second isolated retinal artery in eyes with and without branch retinal vein obstruction (BRVO).</AbstractText>A retrospective study of the color photographs and fluorescein angiograms of 100 patients with unilateral BRVO (64 superotemporal and 34 inferotemporal) and a control group of 33... |
28,498 | Evaluation of arterial stiffness in patients with branch retinal vein occlusion. | To assess the arterial stiffness in patients with branch retinal vein occlusion (BRVO).</AbstractText>Brachial-ankle pulse wave velocity (PWV) and ankle-brachial index were measured in 10 patients with BRVO (mean age 67.9 +/- 7.5 years) and in 18 age-matched controls (mean age 66.9 +/- 6.8 years). The controls were sub... |
28,499 | Hormone treatment of the adult transsexual patient. | Hormonal reassignment has two aims: (1) to reduce the hormonally induced secondary sex characteristics of the original sex and (2) to induce the secondary sex characteristics of the new sex. In Europe, cyproterone acetate is generally used to inhibit androgens in male-to-female transsexuals. Medroxyprogesterone acetate... |
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