CUI1 stringlengths 8 8 | RELA stringlengths 3 54 | CUI2 stringlengths 8 8 | Name1 stringlengths 1 2.86k ⌀ | Name2 stringlengths 1 2.86k ⌀ | Def1 stringlengths 1 8.95k ⌀ | Def2 stringlengths 1 8.95k ⌀ |
|---|---|---|---|---|---|---|
C0000102 | mapped_to | C1451557 | 1-Naphthylamine | 4-(dimethylamino)naphthalene-1-boronic acid | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1570546 | 1-Naphthylamine | 4-(2-chloroethyl)-3-(5,6,7-trimethoxyindolyl-2-carboxamido)-1-naphthylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1609426 | 1-Naphthylamine | N(6)-(1-naphthyl)adenosine diphosphate | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1623359 | 1-Naphthylamine | N-phenyl-2-naphthalenamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1686494 | 1-Naphthylamine | N-(o-boronic acid)benzyl-1-naphthylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1737931 | 1-Naphthylamine | 8-(3-(4-cyclohexylpiperazin-1-yl)propyl)-4-methoxy-5,6,7,8-tetrahydronaphthalen-1-ylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1741066 | 1-Naphthylamine | N-allyl-4-(4'-methyl-piperazinyl)-1,8-naphthalimide | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C1871353 | 1-Naphthylamine | (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C2353033 | 1-Naphthylamine | 1,5-bis(4,6-dichloro-1,3,5-triazinylamino)naphthalene | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C2607396 | 1-Naphthylamine | 1-(2-((1-amino-1,2,3,4-tetrahydronaphthalen-2-yl)carbonylamino)-3-(4-chlorophenyl)propanoyl)-N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C2714550 | 1-Naphthylamine | poly(1-naphthylamine) | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C2714900 | 1-Naphthylamine | N,N-dimethylamino naphthyl acrylic acid ethyl ester | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C2975667 | 1-Naphthylamine | 3-(4,5-bis(dimethylamino)napthalen-1-yl)furan-2,5-dione | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3177617 | 1-Naphthylamine | N,N-dimethylaminonapthyl-(acrylo)-nitrile | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3254240 | 1-Naphthylamine | N,N-bis((E)-2-thienylmethylidene)-1,8-naphthalenediamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3493682 | 1-Naphthylamine | N-(4-amino-1-(2-chloroethyl)naphthalen-2-yl)-5,6,7-trimethoxy-1H-indole-2-carboxamide | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3657512 | 1-Naphthylamine | 15-(naphthalen-1-ylamino)-7-aza-3,11-dioxadispiro(5.1.5(8).3(6))hexadecan-7-oxyl | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3712633 | 1-Naphthylamine | 4-(2-(4-(dimethylamino)naphthalen-1-yl)ethenyl)-1-methylquinolinium | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3713454 | 1-Naphthylamine | 2,2'-(oxybis(2-oxatetramethyleneoxy))-bis(N-(2-naphthyl)benzamide) | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3884887 | 1-Naphthylamine | N,N-bis(salicylidene)naphthylene-1,8-diamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C3885762 | 1-Naphthylamine | 3-(4-fluoro-3-hydroxyphenyl)-N-naphthalen-1-yl-acrylamide | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4045099 | 1-Naphthylamine | naphthalene-1,5-bis(aminomethylidene(bisphosphonic)) acid | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4058704 | 1-Naphthylamine | naphthoquine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4078400 | 1-Naphthylamine | N,N'-bis(2,3,4-trimethoxybenzaldiimine)-1,5-diaminonaphthalene | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4078401 | 1-Naphthylamine | N,N'-bis(2-methoxyphenylidene)-1,5-diaminonaphthalene | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4276542 | 1-Naphthylamine | 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4278921 | 1-Naphthylamine | 1-(6-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-3-(naphthalen-1-yl)guanidine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4507837 | 1-Naphthylamine | 2-acetonyl-1,4-bis((4-etoxybenzensulfonyl)amino)naphthalene | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4546602 | 1-Naphthylamine | N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | mapped_to | C4550114 | 1-Naphthylamine | PJ-68 compound | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | isa | C0000300 | 1-Naphthylamine | 2-Naphthylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | A naphthalene derivative with carcinogenic action. |
C0000102 | isa | C0301275 | 1-Naphthylamine | 4-Nitroso dimethylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | isa | C0303972 | 1-Naphthylamine | N-b-bis (2-chloroethyl)-2-naphthylamine | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | inverse_isa | C0007090 | 1-Naphthylamine | Carcinogens | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. |
C0000102 | inverse_isa | C0027375 | 1-Naphthylamine | naphthalene | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | A white, volatile, solid polycyclic hydrocarbon with a strong mothball odor. Naphthalene is obtained from either coal tar or petroleum distillation and is primarily used to manufacture phthalic anhydride, but is also used in moth repellents. Exposure to naphthalene is associated with hemolytic anemia, damage to the liver and neurological system, cataracts and retinal hemorrhage. Naphthalene is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing laryngeal and colorectal cancer. (NCI05) |
C0000102 | inverse_isa | C0578148 | 1-Naphthylamine | Amine and/or amine derivative | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | inverse_isa | C0682895 | 1-Naphthylamine | Miscellaneous chemical agent | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | inverse_isa | C0729760 | 1-Naphthylamine | Chemical categorised functionally | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | null |
C0000102 | disposition_of | C4521889 | 1-Naphthylamine | Carcinogen (disposition) | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. | A substance that increases the risk of neoplasms in humans or animals either by directly affecting DNA or inducing neoplasms by other mechanisms |
C0000103 | mapped_to | C0046421 | 1-Naphthylisothiocyanate | 2-naphthylisothiocyanate | A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage. | null |
C0000103 | mapped_to | C0636405 | 1-Naphthylisothiocyanate | 4-N,N-dimethylamino-1-naphthylisothiocyanate | A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage. | null |
C0000107 | inverse_isa | C0003364 | 1-Sarcosine-8-Isoleucine Angiotensin II | Antihypertensive Agents | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. |
C0000107 | inverse_isa | C1449680 | 1-Sarcosine-8-Isoleucine Angiotensin II | Angiotensin II Type 1 Receptor Blockers | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS. |
C0000107 | mapped_to | C0103349 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, Sar(1)-Val(5)-Ile(8)- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000107 | mapped_to | C0389411 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, iodo-(Sar(1)-Ile(8))- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000107 | mapped_to | C0608960 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, 1-Sar-7-N-methyl-Ala-8-Ile- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000107 | mapped_to | C0608965 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, 1-Sar-7-nipecotic acid-8-Ile- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000107 | mapped_to | C0628099 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, 1-Sar-7-Sar-8-Ile- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000107 | mapped_to | C0634646 | 1-Sarcosine-8-Isoleucine Angiotensin II | angiotensin II, Sar(1)-aza-Val(3)-Ile(8)- | An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. | null |
C0000139 | inverse_isa | C0003216 | 16,16-Dimethylprostaglandin E2 | Anti-Ulcer Agent | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. |
C0000139 | mapped_to | C0044926 | 16,16-Dimethylprostaglandin E2 | 16,16-dimethylprostaglandin E2 (4-acetamidobenzamido)phenyl ester | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | mapped_to | C0127783 | 16,16-Dimethylprostaglandin E2 | meteneprost | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | mapped_to | C0525964 | 16,16-Dimethylprostaglandin E2 | 19-hydroxy-16,16-dimethylprostaglandin E2 | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | mapped_to | C0611497 | 16,16-Dimethylprostaglandin E2 | 11-methyl-16,16-dimethylprostaglandin E2 | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | mapped_to | C0621831 | 16,16-Dimethylprostaglandin E2 | 16,16-dimethyprostaglandin E2 4-benzaldehyde semicarbazone ester | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | mapped_to | C0628068 | 16,16-Dimethylprostaglandin E2 | 9-deoxy-16,16-dimethyl-tetranor-9-methyleneprostaglandin E2 | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | null |
C0000139 | inverse_isa | C0033568 | 16,16-Dimethylprostaglandin E2 | Prostaglandins, Synthetic | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity. |
C0000139 | subset_includes_concept | C1880653 | 16,16-Dimethylprostaglandin E2 | FDA Established Names and Unique Ingredient Identifier Codes Terminology | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | The terminology that includes terms pertaining to FDA/USP Substance Registration System (SRS), which is to support health information technology initiatives by generating unique ingredient identifiers (UNIIs) for substances in drugs, biologics, foods, and devices. |
C0000139 | subset_includes_concept | C3899741 | 16,16-Dimethylprostaglandin E2 | CTRP Terminology | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | Terminology that is used to support NCI's Clinical Trials Reporting Program (CTRP), a database that captures the required reporting data for all NCI-sponsored clinical trials. |
C0000139 | subset_includes_concept | C3899744 | 16,16-Dimethylprostaglandin E2 | CTRP Agent Terminology | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | A subset of terminology about pharmacologic substances and formulations that are currently being used or tested in clinical trials for the treatment of cancer, cancer-related conditions and chemo/radiotherapy-related side effects. |
C0000139 | subset_includes_concept | C5447243 | 16,16-Dimethylprostaglandin E2 | NCI Drug Dictionary Terminology | A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors. | Terminology created to support the National Cancer Institute (NCI) Drug Dictionary. |
C0000152 | exhibited_by | C1151265 | 17 beta-Hydroxysteroid Dehydrogenases | estradiol 17-beta-dehydrogenase activity | null | null |
C0000163 | mapped_to | C0071742 | 17-Hydroxycorticosteroids | Porter Silber chromogens | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | used_for | C0017710 | 17-Hydroxycorticosteroids | Glucocorticoids | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. |
C0000163 | associated_with | C0523706 | 17-Hydroxycorticosteroids | 17-hydroxycorticosteroid measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The determination of the amount of 17-hydroxycorticosteroids present in a sample. |
C0000163 | associated_with | C0373659 | 17-Hydroxycorticosteroids | Ketogenic steroids, fractionation | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | associated_with | C0523732 | 17-Hydroxycorticosteroids | Ketogenic steroids challenge tests | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0012311 | 17-Hydroxycorticosteroids | 20-alpha-Dihydroprogesterone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA. |
C0000163 | isa | C0033007 | 17-Hydroxycorticosteroids | Pregnanetriol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A metabolite of 17-ALPHA-HYDROXYPROGESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE. |
C0000163 | isa | C0045010 | 17-Hydroxycorticosteroids | 17-alpha-hydroxyprogesterone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES. |
C0000163 | isa | C0056397 | 17-Hydroxycorticosteroids | Cortol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0056399 | 17-Hydroxycorticosteroids | Cortolone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0376260 | 17-Hydroxycorticosteroids | 17-hydroxypregnenolone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
C0000163 | isa | C0606851 | 17-Hydroxycorticosteroids | 17, 21-dihydroxypregnenolone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | inverse_isa | C0582125 | 17-Hydroxycorticosteroids | Corticosteroid and/or corticosteroid derivative | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0373659 | 17-Hydroxycorticosteroids | Ketogenic steroids, fractionation | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_measured_component | C0373659 | 17-Hydroxycorticosteroids | Ketogenic steroids, fractionation | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0523732 | 17-Hydroxycorticosteroids | Ketogenic steroids challenge tests | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_measured_component | C0523732 | 17-Hydroxycorticosteroids | Ketogenic steroids challenge tests | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0580402 | 17-Hydroxycorticosteroids | Urine 17 ketogenic steroid measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_measured_component | C0580402 | 17-Hydroxycorticosteroids | Urine 17 ketogenic steroid measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0702125 | 17-Hydroxycorticosteroids | 17-Ketogenic steroids measurement, 24H urine | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_measured_component | C0702125 | 17-Hydroxycorticosteroids | 17-Ketogenic steroids measurement, 24H urine | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0363798 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Amnio fld:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0363799 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Plas:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0363800 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0484618 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0797744 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0803832 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0941912 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0942044 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^1D post XXX challenge:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C0942045 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post XXX challenge:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C1316681 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SCnc:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C1978080 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^post high dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C1978081 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post high dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C1978082 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^post dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C1978083 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C2735893 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^pre high dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C2735894 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post high dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | measures | C2735895 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^pre dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
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