CUI1 stringlengths 8 8 | RELA stringlengths 3 54 | CUI2 stringlengths 8 8 | Name1 stringlengths 1 2.86k ⌀ | Name2 stringlengths 1 2.86k ⌀ | Def1 stringlengths 1 8.95k ⌀ | Def2 stringlengths 1 8.95k ⌀ |
|---|---|---|---|---|---|---|
C0000163 | measures | C2735896 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0010137 | 17-Hydroxycorticosteroids | cortisone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) |
C0000163 | isa | C0010139 | 17-Hydroxycorticosteroids | Cortodoxone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. |
C0000163 | isa | C0014594 | 17-Hydroxycorticosteroids | Epitestosterone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse. |
C0000163 | isa | C0020268 | 17-Hydroxycorticosteroids | hydrocortisone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. |
C0000163 | isa | C0039664 | 17-Hydroxycorticosteroids | Tetrahydrocortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0039665 | 17-Hydroxycorticosteroids | Tetrahydrocortisone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0045043 | 17-Hydroxycorticosteroids | 18-hydroxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0049390 | 17-Hydroxycorticosteroids | 6 beta-hydroxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0056391 | 17-Hydroxycorticosteroids | cortisone acetate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The acetate ester of cortisone that is used mainly for replacement therapy in adrenocortical insufficiency and in the treatment of many allergic and inflammatory disorders. |
C0000163 | isa | C0063076 | 17-Hydroxycorticosteroids | hydrocortisone probutate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The probutate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. |
C0000163 | isa | C0063077 | 17-Hydroxycorticosteroids | hydrocortisone acetate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. |
C0000163 | isa | C0063079 | 17-Hydroxycorticosteroids | hydrocortisone valerate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The valerate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. |
C0000163 | isa | C0076263 | 17-Hydroxycorticosteroids | Tetrahydrodeoxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0082944 | 17-Hydroxycorticosteroids | hydrocortisone aceponate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0352536 | 17-Hydroxycorticosteroids | hydrocortisone butyrate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The butyrate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leading to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. |
C0000163 | isa | C0443476 | 17-Hydroxycorticosteroids | Free cortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0612688 | 17-Hydroxycorticosteroids | hydrocortisone cypionate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0623842 | 17-Hydroxycorticosteroids | 18-hydroxycortisone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0729349 | 17-Hydroxycorticosteroids | Serum cortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0770559 | 17-Hydroxycorticosteroids | hydrocortisone sodium phosphate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C0770560 | 17-Hydroxycorticosteroids | hydrocortisone sodium succinate | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. |
C0000163 | isa | C1291745 | 17-Hydroxycorticosteroids | 18-hydroxydeoxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C1718635 | 17-Hydroxycorticosteroids | 6-alpha hydroxytetrahydro-11-deoxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C1718697 | 17-Hydroxycorticosteroids | Beta-cortolone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C1955230 | 17-Hydroxycorticosteroids | Free cortisone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C2361965 | 17-Hydroxycorticosteroids | 17-Hydroxyprogesterone+Androstenedione | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | isa | C2736892 | 17-Hydroxycorticosteroids | Allo-tetrahydrodeoxycortisol | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | inverse_isa | C0017710 | 17-Hydroxycorticosteroids | Glucocorticoids | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. |
C0000163 | inverse_isa | C5968530 | 17-Hydroxycorticosteroids | Adrenal glucocorticoid hormone | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0373647 | 17-Hydroxycorticosteroids | Hydroxycorticosteroids, 17- (17-OHCS) | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0523706 | 17-Hydroxycorticosteroids | 17-hydroxycorticosteroid measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The determination of the amount of 17-hydroxycorticosteroids present in a sample. |
C0000163 | has_measured_component | C0523706 | 17-Hydroxycorticosteroids | 17-hydroxycorticosteroid measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | The determination of the amount of 17-hydroxycorticosteroids present in a sample. |
C0000163 | has_component | C0523707 | 17-Hydroxycorticosteroids | 17-Hydroxyketosteroids measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_measured_component | C0523707 | 17-Hydroxycorticosteroids | 17-Hydroxyketosteroids measurement | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_direct_substance | C2182658 | 17-Hydroxycorticosteroids | 24-hour urine 17-hydroxycorticosteroids/creatinine ratio | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C3532175 | 17-Hydroxycorticosteroids | Measurement of 17-hydroxycorticosteroid in 24 hour urine specimen | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | disposition_of | C4521954 | 17-Hydroxycorticosteroids | Adrenal cortex hormone (disposition) | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0363798 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Amnio fld:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0363799 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Plas:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0363800 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0484618 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0797744 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0803832 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0941912 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0942044 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^1D post XXX challenge:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C0942045 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post XXX challenge:SRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1316681 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids:SCnc:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1316682 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids/Creatinine:SRto:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1526473 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids/Creatinine:MRto:Pt:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1639913 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids/Creatinine:MRto:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1978080 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^post high dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1978081 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post high dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1978082 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^post dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C1978083 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post dose dexamethasone:MRat:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C2735893 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^pre high dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C2735894 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post high dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C2735895 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^pre dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000163 | has_component | C2735896 | 17-Hydroxycorticosteroids | 17-Hydroxycorticosteroids^2D post dose dexamethasone:MCnc:24H:Urine:Qn | A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased. | null |
C0000165 | mapped_to | C0046725 | 17-Hydroxysteroid Dehydrogenases | 3 (or 17)-beta-hydroxysteroid dehydrogenase | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C0051833 | 17-Hydroxysteroid Dehydrogenases | androstenedione 17-alpha-oxidoreductase | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C0076183 | 17-Hydroxysteroid Dehydrogenases | testosterone 17 beta-dehydrogenase (NADP+) | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C0268296 | 17-Hydroxysteroid Dehydrogenases | 17-Hydroxysteroid Dehydrogenase Deficiency | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | A rare difference of sex development characterized by 17-beta hydroxysteroid dehydrogenase 3 deficiency that affects individuals with a 46,XY karyotype leading to underandrogenization of the genitalia. |
C0000165 | mapped_to | C1258231 | 17-Hydroxysteroid Dehydrogenases | HSD17B11 protein, human | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | Estradiol 17-beta-dehydrogenase 11 (300 aa, ~33 kDa) is encoded by the human HSD17B11 gene. This protein is involved in the conversion of 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) to androsterone. |
C0000165 | mapped_to | C1311002 | 17-Hydroxysteroid Dehydrogenases | 17beta-hydroxysteroid dehydrogenase type 3 | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C1313632 | 17-Hydroxysteroid Dehydrogenases | 17 beta-hydroxysteroid dehydrogenase type 10, Drosophila | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C1384575 | 17-Hydroxysteroid Dehydrogenases | Hsd17b4 protein, rat | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C1722044 | 17-Hydroxysteroid Dehydrogenases | 17beta-hydroxysteroid dehydrogenase type 11, mouse | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C1849695 | 17-Hydroxysteroid Dehydrogenases | Polycystic Ovarian Disease due to 17-Ketosteroid Reductase Deficiency | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C1871345 | 17-Hydroxysteroid Dehydrogenases | HSD17B14 protein, human | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C2353811 | 17-Hydroxysteroid Dehydrogenases | 17beta-hydroxysteroid dehydrogenase type 13, mouse | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C2607141 | 17-Hydroxysteroid Dehydrogenases | PRAP protein, mouse | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C3500899 | 17-Hydroxysteroid Dehydrogenases | hydroxysteroid (17-beta) dehydrogenase 1, mouse | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C3657904 | 17-Hydroxysteroid Dehydrogenases | Hsd17b2 protein, rat | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C4048183 | 17-Hydroxysteroid Dehydrogenases | 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)) | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C4276497 | 17-Hydroxysteroid Dehydrogenases | DHRS11 protein, human | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C4507204 | 17-Hydroxysteroid Dehydrogenases | HSD17B12 protein, mouse | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000165 | mapped_to | C4705330 | 17-Hydroxysteroid Dehydrogenases | HSD17B13 protein, human | A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-. | null |
C0000167 | mapped_to | C0073701 | 17-Ketosteroids | rubrosterone | Steroids that contain a ketone group at position 17. | null |
C0000167 | mapped_to | C0963144 | 17-Ketosteroids | 5-dihydrorubrosterone | Steroids that contain a ketone group at position 17. | null |
C0000167 | mapped_to | C2604002 | 17-Ketosteroids | androst-3-en-17-one | Steroids that contain a ketone group at position 17. | null |
C0000167 | mapped_to | C2604659 | 17-Ketosteroids | 5alpha-androst-3-en-17-one oxime | Steroids that contain a ketone group at position 17. | null |
C0000167 | associated_with | C0236402 | 17-Ketosteroids | 17-Ketogenic Steroid Measurement | Steroids that contain a ketone group at position 17. | The determination of the amount of total 17-ketogenic steroids present in a sample. |
C0000167 | associated_with | C0523730 | 17-Ketosteroids | 17-Ketosteroids measurement, total | Steroids that contain a ketone group at position 17. | null |
C0000167 | inverse_isa | C0582125 | 17-Ketosteroids | Corticosteroid and/or corticosteroid derivative | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C0484621 | 17-Ketosteroids | 17-Ketosteroids:MRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C0797748 | 17-Ketosteroids | 17-Ketosteroids:SRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C0803834 | 17-Ketosteroids | 17-Ketosteroids:MCnc:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C0941484 | 17-Ketosteroids | 17-Ketosteroids:SCnc:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1316685 | 17-Ketosteroids | 17-Ketosteroids:SCnc:Pt:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1953319 | 17-Ketosteroids | 17-Ketosteroids:MCnc:Pt:Ser:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1977931 | 17-Ketosteroids | 17-Ketosteroids^post dose dexamethasone:MCnc:Pt:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1977932 | 17-Ketosteroids | 17-Ketosteroids^2D post dose dexamethasone:MCnc:Pt:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978076 | 17-Ketosteroids | 17-Ketosteroids^post high dose dexamethasone:MCnc:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978077 | 17-Ketosteroids | 17-Ketosteroids^2D post high dose dexamethasone:MCnc:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978078 | 17-Ketosteroids | 17-Ketosteroids^post dose dexamethasone:MRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978079 | 17-Ketosteroids | 17-Ketosteroids^2D post dose dexamethasone:MRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978103 | 17-Ketosteroids | 17-Ketosteroids^post high dose dexamethasone:MRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | measures | C1978104 | 17-Ketosteroids | 17-Ketosteroids^2D post high dose dexamethasone:MRat:24H:Urine:Qn | Steroids that contain a ketone group at position 17. | null |
C0000167 | inverse_isa | C0038317 | 17-Ketosteroids | Steroids | Steroids that contain a ketone group at position 17. | A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed) |
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