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C0000768
isa
C0000772
Congenital Abnormality
Multiple congenital anomalies
Malformations of organs or body parts during development in utero.
Congenital abnormalities that affect more than one organ or body structure.
C0000768
isa
C0001916
Congenital Abnormality
Albinism
Malformations of organs or body parts during development in utero.
General term for a number of inherited defects of amino acid metabolism in which there is a deficiency or absence of pigment in the eyes, skin, or hair.
C0000768
isa
C0008626
Congenital Abnormality
Congenital chromosomal disease
Malformations of organs or body parts during development in utero.
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
C0000768
isa
C0012241
Congenital Abnormality
Congenital anomaly of gastrointestinal tract
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0035238
Congenital Abnormality
Congenital abnormality of respiratory system
Malformations of organs or body parts during development in utero.
Congenital structural abnormalities of the respiratory system.
C0000768
isa
C0151491
Congenital Abnormality
Congenital musculoskeletal anomalies
Malformations of organs or body parts during development in utero.
Congenital structural abnormalities and deformities of the musculoskeletal system.
C0000768
isa
C0158581
Congenital Abnormality
Ear, face and neck congenital anomalies
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0206762
Congenital Abnormality
Limb Deformities, Congenital
Malformations of organs or body parts during development in utero.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
C0000768
isa
C0266020
Congenital Abnormality
Congenital malposition of digestive organs
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0266271
Congenital Abnormality
Congenital anomaly of endocrine gland
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0266623
Congenital Abnormality
Congenital anomaly of neck
Malformations of organs or body parts during development in utero.
An abnormality of the neck. [https://orcid.org/0000-0002-0736-9199]
C0000768
isa
C0266629
Congenital Abnormality
Congenital anomaly of the hematopoietic system
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0266647
Congenital Abnormality
Congenital anomalies of fetus
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0268230
Congenital Abnormality
Dysmorphic sialidosis, infantile form
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0456309
Congenital Abnormality
Congenital abnormality of lower limb and pelvic girdle
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0497552
Congenital Abnormality
Congenital neurologic anomalies
Malformations of organs or body parts during development in utero.
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
C0000768
isa
C0520555
Congenital Abnormality
Congenital anomaly of head
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0730205
Congenital Abnormality
Congenital anomaly of trunk
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0741368
Congenital Abnormality
Congenital anomaly of back
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C1290502
Congenital Abnormality
Congenital anomaly of tongue, salivary gland AND/OR pharynx
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3536895
Congenital Abnormality
Congenital anomaly of integument (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3665496
Congenital Abnormality
Congenital anomaly of cardiovascular system (disorder)
Malformations of organs or body parts during development in utero.
A heart or vascular abnormality which is inborn or present at birth.
C0000768
isa
C3697746
Congenital Abnormality
Single congenital anomaly
Malformations of organs or body parts during development in utero.
null
C0000768
inverse_isa
C0242354
Congenital Abnormality
Congenital Disorders
Malformations of organs or body parts during development in utero.
existing at, and usually before, birth; referring to conditions that are present at birth, regardless of their causation; inborn metabolism disorders are generally not treed here.
C0000768
has_focus
C2919507
Congenital Abnormality
Fluoroscopic percutaneous angiography of heart for complex congenital anomaly with contrast
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0000754
Congenital Abnormality
Congenital abnormal fusion
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0008519
Congenital Abnormality
Ectopic Tissue
Malformations of organs or body parts during development in utero.
A mass of histologically normal tissue present in an abnormal location.
C0000768
isa
C0020636
Congenital Abnormality
Congenital hypoplasia
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0038476
Congenital Abnormality
Supernumerary structure
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0152424
Congenital Abnormality
Common ventricle
Malformations of organs or body parts during development in utero.
Rare congenital heart malformation with a single ventricle (HEART VENTRICLES) instead of the usual two.
C0000768
isa
C0235832
Congenital Abnormality
Congenital hernia
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0243066
Congenital Abnormality
Atresia
Malformations of organs or body parts during development in utero.
A congenital anatomic defect characterised by the absence of a normally present opening in an organ or tissue.
C0000768
isa
C0332865
Congenital Abnormality
Congenital Dysplasia
Malformations of organs or body parts during development in utero.
Abnormal tissue formation due to abnormal cellular organization, which may result in a morphologic defect.
C0000768
isa
C0332885
Congenital Abnormality
congenital stenosis
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0332900
Congenital Abnormality
Congenital abnormal shape, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0332906
Congenital Abnormality
Abnormal communication (morphologic abnormality)
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0332907
Congenital Abnormality
Congenital absence
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0332915
Congenital Abnormality
Congenital failure of fusion
Malformations of organs or body parts during development in utero.
congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts.
C0000768
isa
C0332928
Congenital Abnormality
Congenital septation
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0333001
Congenital Abnormality
Congenital cavitation, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0333005
Congenital Abnormality
Congenital sequestration, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C0686914
Congenital Abnormality
Congenital misalignment, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C1961121
Congenital Abnormality
Congenital vascular anomaly
Malformations of organs or body parts during development in utero.
A congenital abnormality of the arteries and veins, lymph vessels or veins and lymph vessels.
C0000768
isa
C2733175
Congenital Abnormality
Common cardiac atrium
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0000772
Congenital Abnormality
Multiple congenital anomalies
Malformations of organs or body parts during development in utero.
Congenital abnormalities that affect more than one organ or body structure.
C0000768
has_associated_morphology
C0002636
Congenital Abnormality
Amniotic Band Syndrome
Malformations of organs or body parts during development in utero.
A disorder present in the newborn infant in which constriction rings or bands, causing soft tissue depressions, encircle digits, extremities, or limbs and sometimes the neck, thorax, or abdomen. They may be associated with intrauterine amputations.
C0000768
has_associated_morphology
C0003803
Congenital Abnormality
Arnold Chiari Malformation
Malformations of organs or body parts during development in utero.
A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE. Type I features similar, but le...
C0000768
has_associated_morphology
C0003857
Congenital Abnormality
Congenital arteriovenous malformation
Malformations of organs or body parts during development in utero.
Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage...
C0000768
has_associated_morphology
C0003886
Congenital Abnormality
Arthrogryposis
Malformations of organs or body parts during development in utero.
<p>Arthrogryposis</p>
C0000768
has_associated_morphology
C0004135
Congenital Abnormality
Ataxia Telangiectasia
Malformations of organs or body parts during development in utero.
An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmona...
C0000768
has_associated_morphology
C0004903
Congenital Abnormality
Beckwith-Wiedemann Syndrome
Malformations of organs or body parts during development in utero.
A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.
C0000768
has_associated_morphology
C0005689
Congenital Abnormality
Bladder Exstrophy
Malformations of organs or body parts during development in utero.
A birth defect in which the URINARY BLADDER is malformed and exposed, inside out, and protruded through the ABDOMINAL WALL. It is caused by closure defects involving the top front surface of the bladder, as well as the lower abdominal wall; SKIN; MUSCLES; and the pubic bone.
C0000768
has_associated_morphology
C0005859
Congenital Abnormality
Bloom Syndrome
Malformations of organs or body parts during development in utero.
An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
C0000768
has_associated_morphology
C0008297
Congenital Abnormality
Choanal Atresia
Malformations of organs or body parts during development in utero.
A congenital abnormality that is characterized by a blocked CHOANAE, the opening between the nose and the NASOPHARYNX. Blockage can be unilateral or bilateral; bony or membranous.
C0000768
has_associated_morphology
C0008780
Congenital Abnormality
Ciliary Motility Disorders
Malformations of organs or body parts during development in utero.
Conditions caused by abnormal CILIA movement in the body, usually causing KARTAGENER SYNDROME, chronic respiratory disorders, chronic SINUSITIS, and chronic OTITIS. Abnormal ciliary beating is likely due to defects in any of the 200 plus ciliary proteins, such as missing motor enzyme DYNEIN arms.
C0000768
has_associated_morphology
C0008924
Congenital Abnormality
Cleft upper lip
Malformations of organs or body parts during development in utero.
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.
C0000768
has_associated_morphology
C0008925
Congenital Abnormality
Cleft Palate
Malformations of organs or body parts during development in utero.
Congenital fissure of the soft and/or hard palate, due to faulty fusion.
C0000768
has_associated_morphology
C0008928
Congenital Abnormality
Cleidocranial Dysplasia
Malformations of organs or body parts during development in utero.
Autosomal dominant syndrome in which there is delayed closing of the CRANIAL FONTANELLES; complete or partial absence of the collarbones (CLAVICLES); wide PUBIC SYMPHYSIS; short middle phalanges of the fifth fingers; and dental and vertebral anomalies.
C0000768
has_associated_morphology
C0009207
Congenital Abnormality
Cockayne Syndrome
Malformations of organs or body parts during development in utero.
A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by ...
C0000768
has_associated_morphology
C0009726
Congenital Abnormality
Congenital pigmentary skin anomalies
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0010417
Congenital Abnormality
Cryptorchidism
Malformations of organs or body parts during development in utero.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended t...
C0000768
has_associated_morphology
C0011320
Congenital Abnormality
Dens in Dente
Malformations of organs or body parts during development in utero.
Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.
C0000768
has_associated_morphology
C0011430
Congenital Abnormality
Dentin Dysplasia
Malformations of organs or body parts during development in utero.
An apparently hereditary disorder of dentin formation, marked by a normal appearance of coronal dentin associated with pulpal obliteration, faulty root formation, and a tendency for peripheral lesions without obvious cause. (From Dorland, 27th ed)
C0000768
has_associated_morphology
C0011436
Congenital Abnormality
Dentinogenesis Imperfecta
Malformations of organs or body parts during development in utero.
An autosomal dominant disorder of tooth development characterized by opalescent dentin resulting in discoloration of the teeth. The dentin develops poorly with low mineral content while the pulp canal is obliterated.
C0000768
has_associated_morphology
C0011998
Congenital Abnormality
Diastema of Teeth
Malformations of organs or body parts during development in utero.
An abnormal opening or fissure between two adjacent teeth.
C0000768
has_associated_morphology
C0013903
Congenital Abnormality
Ellis-Van Creveld Syndrome
Malformations of organs or body parts during development in utero.
Dwarfism occurring in association with defective development of skin, hair, and teeth, polydactyly, and defect of the cardiac septum. (Dorland, 27th ed)
C0000768
has_associated_morphology
C0013946
Congenital Abnormality
Embryonic cyst of fallopian tube and broad ligament
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0015923
Congenital Abnormality
Fetal Alcohol Syndrome
Malformations of organs or body parts during development in utero.
A condition occurring in FETUS or NEWBORN due to in utero ETHANOL exposure when mother consumed alcohol during pregnancy. It is characterized by a cluster of irreversible BIRTH DEFECTS including abnormalities in physical, mental, and behavior development (such as FETAL GROWTH RETARDATION; MENTAL RETARDATION; ATTENTION ...
C0000768
has_associated_morphology
C0016667
Congenital Abnormality
Fragile X Syndrome
Malformations of organs or body parts during development in utero.
A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males a...
C0000768
has_associated_morphology
C0016696
Congenital Abnormality
Freemartin
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0016696
Congenital Abnormality
Freemartin
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0016873
Congenital Abnormality
Fused Teeth
Malformations of organs or body parts during development in utero.
Two teeth united during development by the union of their tooth germs; the teeth may be joined by the enamel of their crowns, by their root dentin, or by both.
C0000768
has_associated_morphology
C0018522
Congenital Abnormality
Hallermann's Syndrome
Malformations of organs or body parts during development in utero.
An oculomandibulofacial syndrome principally characterized by dyscephaly (usually brachycephaly), parrot nose, mandibular hypoplasia, proportionate nanism, hypotrichosis, bilateral congenital cataracts, and microphthalmia. (Dorland, 27th ed)
C0000768
has_associated_morphology
C0018920
Congenital Abnormality
Hemangioma, Cavernous
Malformations of organs or body parts during development in utero.
A vascular anomaly that is a collection of tortuous BLOOD VESSELS and connective tissue. This tumor-like mass with the large vascular space is filled with blood and usually appears as a strawberry-like lesion in the subcutaneous areas of the face, extremities, or other regions of the body including the central nervous ...
C0000768
has_associated_morphology
C0020186
Congenital Abnormality
Hutchinson's Teeth
Malformations of organs or body parts during development in utero.
An incisor with a half-moon shape incisal edge. []
C0000768
has_associated_morphology
C0020608
Congenital Abnormality
Hypodontia
Malformations of organs or body parts during development in utero.
The congenital absence of one or a few teeth with the exclusion of third molars.
C0000768
has_associated_morphology
C0021193
Congenital Abnormality
Indeterminate sex and pseudohermaphroditism
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0022521
Congenital Abnormality
Kartagener Syndrome
Malformations of organs or body parts during development in utero.
An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.
C0000768
has_associated_morphology
C0022739
Congenital Abnormality
Klippel-Trenaunay-Weber Syndrome
Malformations of organs or body parts during development in utero.
A congenital disorder that is characterized by a triad of capillary malformations (HEMANGIOMA), venous malformations (ARTERIOVENOUS FISTULA), and soft tissue or bony hypertrophy of the limb. This syndrome is caused by mutations in the VG5Q gene which encodes a strong angiogenesis stimulator.
C0000768
has_associated_morphology
C0023003
Congenital Abnormality
Langer-Giedion Syndrome
Malformations of organs or body parts during development in utero.
Autosomal dominant disorder characterized by cone-shaped epiphyses in the hands and multiple cartilaginous exostoses. INTELLECTUAL DISABILITY and abnormalities of chromosome 8 are often present. The exostoses in this syndrome appear identical to those of hereditary multiple exostoses (EXOSTOSES, HEREDITARY MULTIPLE).
C0000768
has_associated_morphology
C0023138
Congenital Abnormality
Laurence-Moon Syndrome
Malformations of organs or body parts during development in utero.
An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;3...
C0000768
has_associated_morphology
C0024421
Congenital Abnormality
Macroglossia
Malformations of organs or body parts during development in utero.
The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (Fr...
C0000768
has_associated_morphology
C0024433
Congenital Abnormality
Macrostomia
Malformations of organs or body parts during development in utero.
Greatly exaggerated width of the mouth, resulting from failure of union of the maxillary and mandibular processes, with extension of the oral orifice toward the ear. The defect may be unilateral or bilateral. (Dorland, 27th ed)
C0000768
has_associated_morphology
C0024814
Congenital Abnormality
Marinesco-Sjogren syndrome
Malformations of organs or body parts during development in utero.
A rare autosomal recessive disorder characterized by cerebellar ataxia, early-onset bilateral cataracts, chronic myopathy; additional features are delayed motor development and variable intellectual disability, hypergonadotrophic hypogonadism and delayed puberty, and short stature.
C0000768
has_associated_morphology
C0025237
Congenital Abnormality
Melnick-Needles Syndrome
Malformations of organs or body parts during development in utero.
Melnick-Needles syndrome (MNS) belongs to the otopalatodigital syndrome spectrum disorder and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in impaired speech and masticatory problems.
C0000768
has_associated_morphology
C0025988
Congenital Abnormality
Microglossia
Malformations of organs or body parts during development in utero.
Decreased length and width of the tongue. [PMID:19125428]
C0000768
has_associated_morphology
C0026034
Congenital Abnormality
Microstomia
Malformations of organs or body parts during development in utero.
A congenital defect in which the mouth is unusually small. (Dorland, 27th ed)
C0000768
has_associated_morphology
C0026363
Congenital Abnormality
Mohr Syndrome
Malformations of organs or body parts during development in utero.
Oral-facial-digital (OFD) type 2 is characterized by hand and feet deformities, facial deformities, midline cleft of the upper lip and tongue hamartomas.
C0000768
has_associated_morphology
C0026505
Congenital Abnormality
Monster (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0026633
Congenital Abnormality
Mouth Abnormalities
Malformations of organs or body parts during development in utero.
Congenital absence of or defects in structures of the mouth.
C0000768
has_associated_morphology
C0026760
Congenital Abnormality
Multiple Epiphyseal Dysplasia
Malformations of organs or body parts during development in utero.
A rare group of primary bone dysplasia disorders characterized by the association of epiphyseal anomalies of long bones causing joint pain early in life, recurrent osteochondritis and early arthrosis. This group contains an heterogeneous group of diseases with variable expression. Common reported clinical signs include...
C0000768
has_associated_morphology
C0027443
Congenital Abnormality
Natal Teeth
Malformations of organs or body parts during development in utero.
Predeciduous teeth present at birth. They may be well formed and normal or may represent hornified epithelial structures without roots. They are found on the gingivae over the crest of the ridge and arise from accessory buds of the dental lamina ahead of the deciduous buds or from buds of the accessory dental lamina. (...
C0000768
has_associated_morphology
C0028326
Congenital Abnormality
Noonan Syndrome
Malformations of organs or body parts during development in utero.
A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype ...
C0000768
has_associated_morphology
C0028860
Congenital Abnormality
Oculocerebrorenal Syndrome
Malformations of organs or body parts during development in utero.
A sex-linked recessive disorder affecting multiple systems including the EYE, the NERVOUS SYSTEM, and the KIDNEY. Clinical features include congenital CATARACT; MENTAL RETARDATION; and renal tubular dysfunction (FANCONI SYNDROME; RENAL TUBULAR ACIDOSIS; X-LINKED HYPOPHOSPHATEMIA or vitamin-D-resistant rickets) and SCOL...
C0000768
has_associated_morphology
C0028878
Congenital Abnormality
Odontogenesis Imperfecta
Malformations of organs or body parts during development in utero.
null
C0000768
has_associated_morphology
C0029294
Congenital Abnormality
Orofaciodigital Syndromes
Malformations of organs or body parts during development in utero.
Two syndromes of oral, facial, and digital malformations. Type I (Papillon-Leage and Psaume syndrome, Gorlin-Psaume syndrome) is inherited as an X-linked dominant trait and is found only in females and XXY males. Type II (Mohr syndrome) is inherited as an autosomal recessive trait.
C0000768
has_associated_morphology
C0029422
Congenital Abnormality
Osteochondrodysplasias
Malformations of organs or body parts during development in utero.
Abnormal development of cartilage and bone.
C0000768
has_associated_morphology
C0030360
Congenital Abnormality
Papillon-Lefevre Disease
Malformations of organs or body parts during development in utero.
Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease.
C0000768
has_associated_morphology
C0031900
Congenital Abnormality
Pierre Robin Syndrome
Malformations of organs or body parts during development in utero.
Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-ex...
C0000768
has_associated_morphology
C0032339
Congenital Abnormality
Rothmund-Thomson syndrome
Malformations of organs or body parts during development in utero.
An autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, often accompanied by juvenile cataracts, saddle nose, congenital bone defects, disturbances in the growth of HAIR; NAILS; and TEETH; and HYPOGONADIS...