CUI1 stringlengths 8 8 | RELA stringlengths 3 54 | CUI2 stringlengths 8 8 | Name1 stringlengths 1 2.86k ⌀ | Name2 stringlengths 1 2.86k ⌀ | Def1 stringlengths 1 8.95k ⌀ | Def2 stringlengths 1 8.95k ⌀ |
|---|---|---|---|---|---|---|
C0000503 | form_of | C5398272 | oxybate | calcium oxybate | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | form_of | C5398273 | oxybate | magnesium oxybate | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | form_of | C5398274 | oxybate | potassium oxybate | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | tradename_of | C5401684 | oxybate | Xywav | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | tradename_of | C5814558 | oxybate | Lumryz | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_contraindicated_class | C0001948 | oxybate | Alcohol consumption | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. |
C0000503 | has_contraindicated_class | C0004745 | oxybate | Barbiturates | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS. |
C0000503 | may_be_treated_by | C0007384 | oxybate | Cataplexy | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accomp... |
C0000503 | therapeutic_class_of | C0007680 | oxybate | Central Nervous System Agents | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into specific agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and nonspecific agents, those producing effects on different tar... |
C0000503 | has_contraindicated_drug | C0268631 | oxybate | succinic semialdehyde dehydrogenase deficiency | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | An autosomal recessive condition caused by mutation(s) in the ALDH5A1 gene, encoding succinate-semialdehyde dehydrogenase, mitochondrial. It is characterized by intellectual disability, developmental delay, and hypotonia. |
C0000503 | has_ingredient | C1168539 | oxybate | sodium oxybate 500 MG/ML | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C1253030 | oxybate | oxybate Oral Solution | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | physiologic_effect_of | C1371428 | oxybate | Decreased Central Nervous System Organized Electrical Activity | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | physiologic_effect_of | C1371776 | oxybate | Decreased Organized Electrical Activity | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | mechanism_of_action_of | C1373018 | oxybate | GABA B Agonists [MoA] | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | mechanism_of_action_of | C1373108 | oxybate | Unknown Cellular or Molecular Interaction [MoA] | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | physiologic_effect_of | C2917137 | oxybate | Central Nervous System Depression [PE] | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5399571 | oxybate | oxybate Oral Liquid Product | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5399572 | oxybate | oxybate Oral Product | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5401643 | oxybate | calcium oxybate 234 MG/ML | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5401644 | oxybate | magnesium oxybate 96 MG/ML | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5401645 | oxybate | potassium oxybate 130 MG/ML | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5401646 | oxybate | sodium oxybate 40 MG/ML | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814554 | oxybate | sodium oxybate 4500 MG | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814555 | oxybate | oxybate Granule Product | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814556 | oxybate | oxybate Granules for Oral Suspension | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814564 | oxybate | sodium oxybate 6000 MG | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814568 | oxybate | sodium oxybate 7500 MG | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_ingredient | C5814572 | oxybate | sodium oxybate 9000 MG | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C0943698 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Bld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C0945568 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Ser/Plas:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C0945569 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Urine:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1113794 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:Urine:Ord | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1714566 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Ser/Plas:Qn:Confirm | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1714569 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:Urine:Ord:Screen | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1714570 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Urine:Qn:Confirm | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1715593 | oxybate | Gamma hydroxybutyrate/Creatinine:MRto:Pt:Urine:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1717416 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:Ser/Plas:Ord | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1952748 | oxybate | Gamma hydroxybutyrate/Creatinine:SRto:Pt:Urine:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1978004 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:Amnio fld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C1978810 | oxybate | Gamma hydroxybutyrate cutoff:MCnc:Pt:Ser/Plas:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C2718129 | oxybate | Deprecated Gamma hydroxybutyrate [Mass/volume] in Urine | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C2736160 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:Urine:Ord:Confirm | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C2923607 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:Ser/Plas:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C2925682 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:Ser/Plas:Ord:Screen | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3261452 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:Urine:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3262313 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:Gast fld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3262803 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:XXX:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3533358 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:CSF:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3654202 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Ser/Plas/Bld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C3847040 | oxybate | Gamma hydroxybutyrate:SCnc:Pt:Bld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C4036665 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:XXX:Ord:Screen | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C4070744 | oxybate | Gamma hydroxybutyrate:MCnt:Pt:Hair:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C4070774 | oxybate | Gamma hydroxybutyrate:MCnc:Pt:Body fld:Qn | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_component | C4265207 | oxybate | Gamma hydroxybutyrate:PrThr:Pt:XXX:Ord:Confirm | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000503 | has_active_moiety | C5398054 | oxybate | calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution [Xywav] | hydroxy derivative of butyric acid substituted at the gamma, or 4 position; intermediate in the metabolism of gamma-aminobutyric acid (GABA). | null |
C0000506 | inverse_isa | C0003280 | 4-Hydroxycoumarins | Anticoagulants | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | Agents that prevent BLOOD CLOTTING. |
C0000506 | inverse_isa | C0014432 | 4-Hydroxycoumarins | Enzyme Inhibitors | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. |
C0000506 | mapped_to | C0052133 | 4-Hydroxycoumarins | antivitamins K | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0054088 | 4-Hydroxycoumarins | bromadiolone | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0054095 | 4-Hydroxycoumarins | bromfenacoum | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0055901 | 4-Hydroxycoumarins | clocoumarol | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0056423 | 4-Hydroxycoumarins | coumatetralyl | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0057978 | 4-Hydroxycoumarins | difenacoum | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0060459 | 4-Hydroxycoumarins | flocoumafen | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0070718 | 4-Hydroxycoumarins | phepromaron | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0097101 | 4-Hydroxycoumarins | 4-hydroxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0175157 | 4-Hydroxycoumarins | cyclocumarol | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0244314 | 4-Hydroxycoumarins | fumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0258329 | 4-Hydroxycoumarins | PD 099560 | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0378374 | 4-Hydroxycoumarins | difethialone | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0386293 | 4-Hydroxycoumarins | 3-phenoxy-4-hydroxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0391069 | 4-Hydroxycoumarins | NSC 158393 | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0607698 | 4-Hydroxycoumarins | thiol reductone | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0639868 | 4-Hydroxycoumarins | 5,8-dihydroxy-7-(4-hydroxy-5-methylcoumarin-3-yl)coumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0639870 | 4-Hydroxycoumarins | 3,8-dihydroxy-4-methoxy-2-oxo-2-H-1-benzopyran-5-carboxylic acid | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0639871 | 4-Hydroxycoumarins | 3,8-dihydroxy-4-methoxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0643297 | 4-Hydroxycoumarins | 3-(4-azido-5-iodosalicylamido)-4-hydroxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C0644737 | 4-Hydroxycoumarins | 3-(4-azidobenzyl)-4-hydroxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C1172087 | 4-Hydroxycoumarins | derrusnine | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C1742843 | 4-Hydroxycoumarins | 4-(bis(4-hydroxy-2-oxo-2H-benzopyran-3-yl)methyl)benzophenone | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | mapped_to | C2717246 | 4-Hydroxycoumarins | 3-benzoyl-7-dimethylamino-4-hydroxycoumarin | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | measures | C3699493 | 4-Hydroxycoumarins | 4-hydroxycoumarins:PrThr:Pt:XXX:Ord:Screen | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000506 | has_component | C3699493 | 4-Hydroxycoumarins | 4-hydroxycoumarins:PrThr:Pt:XXX:Ord:Screen | Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants. | null |
C0000507 | used_for | C0030065 | 4-Hydroxyphenylpyruvate Dioxygenase | Oxygenases | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules. |
C0000507 | associated_with | C0268623 | 4-Hydroxyphenylpyruvate Dioxygenase | Tyrosinemia, Type III | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | A rare inborn error of tyrosine metabolism characterized by mild hypertyrosinemia and increased urinary excretion of 4-hydroxyphenylpyruvate, 4-hydroxyphenyllactate and 4-hydroxyphenylacetate. |
C0000507 | associated_with | C2931042 | 4-Hydroxyphenylpyruvate Dioxygenase | Hawkinsinuria | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | A rare inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin ((2-l-cystein-S-yl, 4-dihydroxycyclohex-5-en-1-yl)acetic acid), in the urine. |
C0000507 | inverse_isa | C0599874 | 4-Hydroxyphenylpyruvate Dioxygenase | Dioxygenases | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS. |
C0000507 | disposition_of | C4521991 | 4-Hydroxyphenylpyruvate Dioxygenase | Oxidoreductase (disposition) | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | null |
C0000507 | exhibited_by | C1151566 | 4-Hydroxyphenylpyruvate Dioxygenase | 4-hydroxyphenylpyruvate dioxygenase activity | An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. [EC:1.13.11.27] |
C0000511 | inverse_isa | C0007090 | 4-Nitroquinoline-1-oxide | Carcinogens | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. |
C0000511 | inverse_isa | C0026879 | 4-Nitroquinoline-1-oxide | Mutagens | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. |
C0000511 | mapped_to | C0047565 | 4-Nitroquinoline-1-oxide | 3-methyl-4-nitroquinoline 1-oxide | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | null |
C0000511 | mapped_to | C0601527 | 4-Nitroquinoline-1-oxide | 2-methyl-4-nitroquinoline 1-oxide | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | null |
C0000511 | mapped_to | C0601588 | 4-Nitroquinoline-1-oxide | 6-nitroquinoline 1-oxide | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | null |
C0000511 | mapped_to | C0769703 | 4-Nitroquinoline-1-oxide | 4-nitroquinolone-1-oxide | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | null |
C0000511 | mapped_to | C0175777 | 4-Nitroquinoline-1-oxide | Nitroquinoline oxide | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | null |
C0000511 | used_for | C0034424 | 4-Nitroquinoline-1-oxide | Quinolines | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | bicyclic aromatic ring structure with one ortho nitrogen. |
C0000511 | inverse_isa | C0019398 | 4-Nitroquinoline-1-oxide | Heterocyclic Compounds | A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage. | Cyclic compounds that include atoms other than carbon in their ring structure. |
C0000530 | mapped_to | C0640731 | 5'-NUCLEOTIDASE | 5'(3')-nucleotidase | A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5. | null |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.