Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,351,367	satellit glia adult dorsal root ganglia harbor stem cell yield glia physiolog condit neuron respons injuri presenc putat stemprogenitor cell suggest adult peripher nervous system pns tissu includ dorsal root ganglion drg date identif fate pathophysiolog condit address combin multipl vitro vivo approach identifi presenc stem cell adult drg satellit glial popul progenitor present drgs sciatic nerv cell specif transgen mous line highlight prolif potenti drg stem cell progenitor vitro drg stem cell gliogen neurogen potenti wherea progenitor essenti gliogen lineag trace show physiolog condit adult drg stem cell maintain drg homeostasi suppli satellit glia patholog condit adult drg stem cell replac drg neuron lost injuri addit renew satellit glial pool novel find open new avenu develop therapeut strategi target drg stem cell pns disord	D005727;D053687	T023;T025
36,351,340	chang toward healthier lifestyl associ better health relat qualiti life long term colorect cancer survivor littl known chang constel lifestyl factor affect health relat qualiti life hrqol colorect cancer crc survivor studi aim investig associ chang healthi lifestyl hrqol time survivor stage iv crc	D011788;D015179	T078;T191
36,351,338	healthcar access dimens guidelin concord ovarian cancer treatment seer medicar analysi orchid studi racial dispar exist receipt guidelin concord treatment ovarian cancer oc howev studi evalu various dimens healthcar access hca contribut dispar	D044465;D010051	T098;T191
36,351,336	associ frailti time aliv home cancer surgeri among older adult popul base analysi although frailti known impact short term postop outcom long term impact unknown studi examin associ frailti remain aliv home cancer surgeri among older adult	D000073496;D009369	T033;T184;T046;T191
36,351,335	nccn guidelin insight gastrointestin stromal tumor version gastrointestin stromal tumor gist common type soft tissu sarcoma occur throughout gastrointestin tract tumor caus oncogen activ mutat kit pdgfra gene nccn guidelin gist provid recommend diagnosi evalu treatment follow patient tumor nccn guidelin insight summar panel discuss behind recent import updat guidelin includ revis system therapi option unresect progress metastat gist base mutat status updat recommend manag gist develop resist specif tyrosin kinas inhibitor	D046152	T191
36,351,334	pediatr aggress matur b cell lymphoma version nccn clinic practic guidelin oncolog nccn clinic practic guidelin oncolog nccn guidelin pediatr aggress matur b cell lymphoma includ recommend diagnosi manag pediatr patient primari mediastin larg b cell lymphoma pmbl sporad variant burkitt lymphoma diffus larg b cell lymphoma pmbl consid distinct entiti aris matur thymic b cell account matur b cell lymphoma children adolesc discuss section includ recommend outlin nccn guidelin diagnosi manag pediatr patient pmbl	D016403	T191
36,351,333	brafmek dual inhibitor therapi progress anaplast pleomorph xanthoastrocytoma case seri literatur review recurr anaplast pleomorph xanthoastrocytoma r apxa rare primari brain tumor challeng treat two third pxa tumor harbor braf gene mutat braf inhibitor shown improv tumor control howev resist braf inhibit develop case concurr therapi mek inhibitor may improv tumor control patient surviv studi identifi patient diagnos braf mutat pxa receiv braf mek inhibitor year interv institut patient record evalu includ treatment advers effect ae outcom patholog next generat sequenc mri median age year rang year male anaplast pxa median overal surviv month rang month patient die tumor relat hemorrhag therapi experienc long term diseas control month respect dual brafmek inhibitor well toler grade ae includ rash neutropenia fatigu abdomin discomfort diarrhea grade ae detect literatur review also perform patient diagnos braf mutat pxa treat braf andor mek inhibitor august total case identifi median age year rang year median pfs os month rang month month rang month respect common ae grade fatigu skin rash result case seri literatur review indic dual drug therapi braf mek inhibitor r apxa braf mutat may delay tumor progress without unexpect ae	D001932;D001254	T191
36,351,332	paid sick leav among work cancer survivor associ use prevent servic unit state sought examin lack paid sick leav among work cancer survivor sociodemographicsocioeconom employ characterist associ prevent servic use unit state	D000073116;D009369	T201;T191;T101
36,351,331	associ cancer center accredit complianc price disclosur common oncolog surgic procedur cancer center accredit status predic sever factor measur high valu healthcar howev price transpar critic healthcar decis qualiti measur includ accredit report rate price disclosur surgic procedur cancer breast lung cutan melanoma colon prostat among hospit rank american colleg surgeon commiss cancer ac coc	D008545;D001943;D012878	T191
36,351,330	incid cancer detect multipl wave covid tsunami earthquak popul base studi exist demonstr full spectrum impact covid hinder incid cancer detect larg cancer system build upon previous public jnccn conduct updat analysi use month new data accru pandem era extend studi period septemb octob demonstr multipl covid wave affect week cancer incid volum ontario canada fulli clear backlog end wave	D000086382;D055866;D009369	T047;T070;T191;T067
36,351,324	cpt mediat ioniz radiat induc intestin injuri prolifer via shift fao metabol pathway activ erk jnk pathway intestin compensatori prolif potenti key influenc factor suscept radiat induc intestin injuri studi indic carnitin palmitoyltransferas cpt mediat fatti acid oxid fao play crucial role promot surviv prolifer tumor cell aim explor effect co gamma ray cpt mediat fao radiat induc intestin injuri model investig role cpt mediat fao surviv prolifer intestin cell irradi detect chang fao plasma small intestin spragu dawley sd rat h co gamma irradi gy use target metabolom qrt pcr immunohistochemistri ihc western blot wb relat enzymat activ kit analyz fao chang radiat induc intestin injuri model regardless ex vivo mice enteroid vitro normal human intestin epitheli cell line hiec hiec cell transduc lentivirus vector gv treat puromycin obtain cpt stabl knockout cell line name cpt ko cpt enzymat activ hiec cell mice enteroid also inhibit pharmaceut inhibitor st etomoxir eto studi function cpt surviv prolifer hiec cell co gamma irradi found cpt mediat fao alter small intestin sd rat irradi especi express level enzymat activ cpt signific increas similar express level cpt also remark enhanc mice enteroid hiec cell irradi cpt inhibit decreas prolifer hiec cell mice enteroid irradi partial reduc extracellular signal regul kinas erk c jun n termin kinas jnk pathway activ cpt inhibit also reduc prolifer mice enteroid irradi partial regul wnt catenin signal activ conclus studi indic cpt play crucial role promot intestin epitheli cell prolifer irradi	D002334;D020935	T126;T116;T044
36,351,222	singl side deaf emot social handicap impact health status qualiti life function hear effect cochlear implant evalu function subject outcom individu singl side deaf ssd treat cochlear implant ci	D019929;D014012;D046088;D013067;D003054;D003638	T061;T184;T033;T037;T047;T074;T041
36,351,213	diffus larg b cell lymphoma chile impact combin chop plus rituximab public health system diffus larg b cell lymphoma dlbcl common lymphoma subtyp purpos studi evalu clinic featur prognost factor result dlbcl treat cancer center public health system chile compar cyclophosphamid doxorubicin vincristin prednison chop rituximab cyclophosphamid doxorubicin vincristin prednison r chop	D015658;D016403	T047;T191
36,351,212	impact covid pandem cancer stage analysi patient breast cancer communiti practic brazil nationwid lockdown enforc brazil start march covid pandem cancer screen activ reduc studi evalu impact covid pandem breast cancer bc diagnosi	D001943;D000086382	T047;T191;T067
36,351,211	real world evid health outcom relat lung stereotact bodi radiat therapi brazil stereotact bodi radiat therapi sbrt effect option patient earli stage oligometastat non small cell lung cancer nsclc howev data latin america limit therefor aim studi investig real world outcom appli sbrt lung lesion brazilian institut	D016634;D002289;D008175	T061;T191
36,351,203	post fire dynam tree veget forest without histori select log eastern amazon worldwid forest suscept fire forest fire select log interact requir monitor evalu studi evalu phytosociolog dynam tree veget disturb forest df undisturb forest uf select log area affect fire brazilian east amazon tree dbh cm measur identifi botan plot x df area plot x uf area log two year fire analysi speci tree composit divers similar mortal recruit carri fire affect df uf area similar proport term tree loss basal area intensifi mortal rate short term year fire caus signific reduct speci divers tendenc toward similar loss speci composit area disturb log subsequ assess necessari understand forest recoveri mechan	D014197;D005390	T067;T002
36,351,202	algorithm colinear chain overlap gap cost colinear chain proven power heurist find near optim align long dna sequenc eg long read genom assembl refer use intermedi step sever align tool employ seed chain extend strategi despit popular effici subquadrat time algorithm general case chain support anchor overlap gap cost current known present algorithm solv colinear chain problem anchor overlap gap cost n time n denot count anchor degre polylogarithm factor depend type anchor use eg fix length anchor type preced optim anchor chain requir satisfi also establish first theoret connect colinear chain cost edit distanc specif prove fix set anchor care design chain cost function optim anchor edit distanc equal optim colinear chain cost anchor edit distanc two sequenc set anchor slight general standard edit distanc add addit cost one align two match symbol support anchor final demonstr experiment optim colinear chain cost propos cost function comput order magnitud faster edit distanc achiev correl coeffici edit distanc close well distant relat sequenc	D000465	T170
36,351,192	ultrasound guid templ filler inject templ filler volum signific improv facial balanc appear signific risk includ contour irregular vascular occlus skin necrosi hair loss blind stroke nonthrombot pulmonari embol improv safeti precis templ volum introduc ultrasound guid inject hyaluron acid filler use interfasci space target filler placement review relev anatomi includ figur describ techniqu ultrasound guid filler inject interfasci plane real time visual cannula filler deposit includ detail video procedur	D003357	T061
36,351,187	miss part vital inform abstract avail	D014799	T078
36,351,186	compar cross section studi phasic heart rate variabl work memori among young adult heart rate variabl hrv could promis earli biomark cognit impair better understand reaction pattern cardiovascular cognit function help predict prevent manifest diseas addit benefici cardiovascular evid yoga promis lack short term approxim one year cross section investig	D008570;D001341	T022;T041
36,351,185	effect yoga psycholog health sleep qualiti patient acut insomnia preliminari studi insomnia poor sleep qualiti associ impair physic psycholog mental function individu requir health well	D015013;D007319;D019122;D012893	T061;T184;T047;T041;T048
36,351,094	adolesc nurs consult import excerpt care provid nurs brazilian state care adolesc without chronic diseas must complet standard focus individu demand transit process adult care adher treatment studi aim character care provid nurs state paulo work adolesc	D009732;D009726	T058;T097
36,351,093	nurs health care gay adolesc analyz nurs statement health care gay adolesc	D000072339;D012749;D009726	T047;T098;T097
36,351,092	manag overweight obes children adolesc nurs mix method studi analyz manag overweight obes children adolesc nurs famili health strategi	D050177;D063766	T033;T047
36,351,091	exclus breastfeed abandon adolesc mother cohort studi within health primari servic analyz factor associ abandon exclus breastfeed adolesc mother first month infant life	D001942;D000088662	T055;T099;T040;T102;T058
36,351,090	associ health literaci covid threat vaccin intent among brazilian adolesc investig influenc health literaci assess covid threat health intent vaccin among brazilian adolesc	D057220;D000086382	T047;T067;T041
36,351,089	health inequ among homeless adolesc highlight health inequ homeless adolesc base conceptu framework social determin health	D006297;D006703	T033;T098;T095;T080
36,351,088	biograph ruptur covid pandem adolesc young tran men transmasculin peopl demand nurs understand biograph ruptur caus covid pandem adolesc young tran men transmasculin peopl brazilian context	D058873;D000086382	T047;T067
36,351,087	emot behavior problem adolesc context covid mix method studi estim preval emot behavior problem adolesc context covid pandem e explor adolesc percept emot behavior problem identifi	D000066553;D000086382;D000294	T067;T055;T033;T047;T048
36,351,086	prevent non suicid self injuri construct valid educ materi develop valid educ materi strengthen adolesc health care non suicid self injuri	D016728	T055
36,351,085	adolesc understand chemotherapi relat advers event concept elicit studi document adolesc understand chemotherapi relat core advers event pediatr patient report outcom version common terminolog criteria advers event thus begin valid process tool item brazilian adolesc	D000071066;D009369	T170;T191
36,351,070	patient safeti cultur incid record nurs shift chang intens care unit analyz associ patient safeti cultur perceiv nurs profession incid record nurs shift intens care unit	D061214;D009728	T058;T097
36,351,069	incid risk factor postintens care syndrom cohort critic ill patient determin incid postintens care syndrom cohort critic ill patient admit intens care unit identifi risk factor relat develop physic cognit mental health area	D016638;D007362	T047;T073;T093
36,351,068	prognost valu peripher ischem microvascular reserv sepsi relat calcitonin gene relat peptid substanc p evalu mechan attribut prognost valu peripher ischem microvascular reserv patient sepsi	D006940;D018805;D009479	T123;T047;T046;T116
36,351,067	robust maintain emerg invas mechan ventil develop simpl robust safe effici invas mechan ventil use remot area world war zone practic util sophist equip limit consider maintain avail part transport andor cost	D012122;D045422	T061;T074
36,351,066	critic covid neurolog dysfunct direct compar analysi sar cov infecti pathogen evalu whether critic sar cov infect frequent associ sign corticospin tract dysfunct neurolog sign symptom syndrom infecti pathogen	D000086382;D009422;D012128	T047;T067
36,351,065	clinic outcom lung mechan characterist covid non covid associ acut respiratori distress syndrom propens score analysi two major random trial compar lung mechan outcom covid associ acut respiratori distress syndrom non covid associ acut respiratori distress syndrom	D000086382;D012128	T047;T067
36,351,064	autom document vital paramet ward use portabl station effect proper trigger rapid respons team studi protocol cluster random clinic trial evalu effect welch allyn connex spot monitorhillrom connecta solut activ rapid respons team time manner compar manual activ	D057209;D000086382	T058;T067;T097;T047
36,351,061	map venom stingray potamotrygon genus tiet river paulo sstate brazil freshwat stingray fish adapt river lake south america expans potamotrygonida famili paran river began dam sete queda fall reach mouth paranapanema tiet river approxim year ago via lock hydroelectr power plant aggress anim howev one four stinger tail cover venom produc epithelium caus sever envenom fishermen bather step manipul	D012860	T013
36,351,019	heighten apoptot prime vascular cell across tissu life span predispos cancer therapi induc toxic although major organ toxic frequent aris patient treat cytotox target cancer therapi mechan drive poor understood report vascular endotheli cell ec high prime apoptosi parenchym cell across mani adult tissu consequ ec readili undergo apoptosi respons mani common use anticanc agent includ cytotox target drug sensit ioniz radiat bh mimet parenchym cell vivo use differenti isogen human induc pluripot stem cell model ec vascular smooth muscl cell vsmcs find vascular cell exhibit distinct drug toxic pattern link diverg therapi induc vascular toxic patient collect result demonstr vascular cell high sensit apoptosi induc stress across life span may repres weakest link vulner multipl tissu develop toxic	D057026;D009369	T191;T025
36,351,018	dna replic initi shape mutat landscap express human genom interplay activ biolog process dna repair central mutagenesi show ubiquit process replic initi mutagen leav specif mutat footprint thousand earli effici replic origin observ mutat pattern consist two distinct mechan reflect two step process origin activ trigger format dna break center origin local error prone dna synthesi immedi vicin demonstr replic initi depend mutat process exert influenc phenotyp divers human disproportion origin genom size increas mutat load gene promot splice junction presenc origin signific influenc gene express mrna isoform usag last show mutagenesi origin drive evolut origin sequenc also contribut sculpt regulatori domain human genom	D015894;D004261	T045;T028
36,351,016	nitroreductas instruct supramolecular assembl microbiom regul enhanc colorect cancer treatment develop human microbiom collect correl sophist interact fusobacterium nucleatum colorect cancer crcs howev treatment crc via disrupt gastrointestin flora remain less explor aim regul activ nitroreductas f nucleatum infect tumor develop nitroreductas instruct supramolecular self assembl design assembl precursor underw enzymat transform form assembl agglutin f nucleatum erad target bacteria assembl anti f nucleatum activ could allevi bacteria induc drug resist effect thus sensit crc cell chemo drug eventu mice bear f nucleatum infect crc local introduct nitroreductas instruct assembl could effici inhibit tumor growth overal studi incorpor nitroreductas broaden toolbox enzym instruct supramolecular self assembl local introduct nitroreductas instruct assembl could target f nucleatum elimin contribut crc drug resist amelior chemotherapi outcom	D015179;D000069196	T191;T001;T007
36,351,009	identif minor popul lmo breast cancer cell integr vasculatur initi metastasi metastasi respons breast cancer relat death howev identifi cellular determin metastasi remain challeng identifi minor popul immatur thi vegfa tumor epitheli cell human breast tumor biopsi display angiogen featur mark express oncogen lmo higher abund lmo basal cell correl tumor endotheli content predict poor distant recurr free surviv patient use mmtv pymtlmocreert mice demonstr lmo lineag trace cell integr vasculatur higher propens metastas lmo knockdown human breast tumor reduc lung metastasi impair intravas lead reduc frequenc circul tumor cell mechanist find lmo bind stat requir stat activ tumor necrosi factor interleukin collect studi identifi popul metastasi initi cell angiogen featur establish lmo stat signal axi therapeut target breast cancer metastasi	D001943;D008175	T191
36,350,993	immun checkpoint therapi forg ahead spatiotempor immun monitor clinic trial revers translat help determin optim combin immun therapi cure cancer	D007167;D009369	T061;T191
36,350,992	next cancer vaccin cancer vaccin shown clinic drive tumor reactiv cell activ prolifer effector function unfortun tumor erad treatment cancer vaccin unsuccess mani patient critic step way improv vaccin efficaci combin immunotherapi standard care treatment	D019496;D009369	T129;T121;T191;T116
36,350,991	advanc beyond twist turn cell exhaust cancer chronic antigen stimul lead cell exhaust nutrient restrict suppress factor tumor microenviron exacerb cell dysfunct better understand heterogen dynam exhaust cd cell guid novel therapi modul cell differenti achiev effect antitumor respons	D018414;D009369	T191;T025
36,350,990	vivo gene immunotherapi cancer cancer becom increas understood diseas patholog cell also one immun hypofunct heterogen patient specif natur cancer underscor need person cellular therapi current produc ex vivo gene modul approach therapeut rnas improv viral vector bring us closer toward strategi mitig diseas particular diseas benefit alter gene transgen express profil patholog therapeut immun cell advanc toolbox technolog trend toward simplifi person therapi foreshadow opportun direct vivo precis medicin cancer	D007167;D009369	T061;T191
36,350,989	combin cancer immunotherapi emerg treatment strategi adapt tumor microenviron immun checkpoint blockad icb revolution cancer treatment howev resist icb occur frequent due tumor intrins alter extrins factor tumor microenviron viewpoint aim give updat recent develop immunotherapi solid tumor highlight progress translat research clinic practic	D059016;D009369	T070;T191
36,350,988	cd target cd bispecif antibodi enhanc antitumor efficaci odronextamab refractori diffus larg b cell lymphoma model although mani patient diffus larg b cell lymphoma dlbcl may achiev complet respons frontlin chemoimmunotherapi patient relapsedrefractori diseas typic poor outcom odronextamab cdxcd bispecif antibodi provid signal activ cell receptorcd complex exhibit earli promis activ patient high refractori dlbcl phase trial howev patient achiev complet respons mani relaps thus repres high unmet medic need investig whether ad costimulatori signal engag cd receptor cell could augment odronextamab activ demonstr regn bispecif antibodi cross link cd express tumor cell cd express cell enhanc odronextamab potenti cell activ cytolyt function preclin dlbcl studi use human immun system reconstitut anim regn promot antitumor activ odronextamab induc intratumor expans reprogramm cell skew away dysfunct state although regn monotherapi show limit activ toxic primat studi augment cell activ dose combin odronextamab addit analysi non hodgkin lymphoma clinic sampl reveal increas cd cd cell odronextamab treatment demonstr presenc popul could potenti target regn collect data demonstr regn mark enhanc antitumor activ odronextamab preclin nhl model combin two bispecif antibodi may provid chemotherapi free approach treatment dlbcl	D018033;D008228;D016403;D000970	T129;T121;T116;T109;T191
36,350,987	interleukin base therapi cancer molecular insight mechan benefici advers effect interleukin il result develop improv il formul il receptor bias tissu target properti sever compound current clinic develop usher il therapi current era cancer immunotherapi	D007376;D009369	T129;T121;T191;T116
36,350,986	blimp nra transcript factor reciproc regul antitumor car cell stem exhaust chimer antigen receptor car cell induc meaning clinic respons solid tumor loss cell stem poor expans capac exhaust prolong tumor antigen exposur major caus car cell therapeut resist singl cell rna sequenc analysi car cell first human trial metastat prostat cancer identifi two independ valid cell state associ antitumor potenc lack efficaci low express prdm encod blimp transcript factor defin high potent tcf encod cell factor tcf express cd car cell wherea enrich havcr encod cell immunoglobulin mucin domain contain tim express cd cell elev prdm associ poor outcom prdm knockout promot tcf depend car cell stem prolifer result margin enhanc leukemia control mice howev set prdm defici negat epigenet feedback program nuclear factor activ cell nfat driven cell dysfunct identifi program character compensatori regul nra gene encod exhaust relat transcript factor hamper cell effector function solid tumor dual knockout prdm nra skew car cell phenotyp away tim cd toward tcf cd counter exhaust tumor infiltr car cell improv antitumor respons effect achiev prdm nra singl knockout alon data underscor dual target prdm nra promis approach advanc adopt cell immuno oncotherapi	D009369;D011987	T191;T116;T192
36,350,985	translat evolv molecular landscap tumor biomark respons cancer immunotherapi immun checkpoint inhibitor ici revolution cancer therapeut trigger studi understand molecular cellular wire respons resist increas understand under biolog respons ici enabl investig tumor intrins extrins featur may predict therapeut outcom parallel liquid biopsi measur circul tumor dna ctdna use assess real time molecular respons guid clinic decis ici combin approach provid deeper understand cancer biolog immunoedit evolut ici promis extend util immunotherapi patient cancer	D009369;D000074141	T191;T114
36,350,984	pool screen car cell identifi divers immun signal domain next generat immunotherapi chimer antigen receptor car repurpos natur signal compon retarget cell refractori cancer shown limit efficaci persist recurr malign introduc car pool multiplex approach rapid identifi car design clinic potenti forti car signal domain deriv rang immun cell lineag evalu pool assay abil stimul critic cell effector function repetit stimul mimic long term tumor antigen exposur sever domain identifi tumor necrosi factor tnf receptor famili primarili associ b cell cd enhanc prolifer wherea b cell activ factor receptor baff r transmembran activ caml interactor taci promot cytotox function enhanc relat clinic benchmark prolong antigen stimul car cell signal domain fell distinct state memori cytotox metabol baff r car cell enrich high cytotox transcript signatur previous associ posit clinic outcom also observ replac bb intracellular signal domain baff r signal domain clinic valid b cell matur antigen bcma specif car result enhanc activ xenotranspl model multipl myeloma togeth result show car pool general approach rapid explor car architectur activ improv efficaci car cell therapi	D009364;D000076962	T129;T191;T116;T192
36,350,974	n methyl r tran hydroxi l prolin major bioactiv compound sideroxylon obtusifolium attenu pilocarpin induc injuri cultur astrocyt glial cell implic tempor lobe epilepsi human model astrocyt lost sever brain region acut seizur induc pilocarpin may suffer hyperplasia subsequ time point studi investig effect n methyl sr tran hydroxi l prolin nmp astrocyt expos cytotox concentr pilocarpin astrocyt incub pilocarpin half maxim inhibitori concentr ic mm h afterward treat nmp concentr rang gml h cell viabil assess dimethylthiazol yl diphenyltetrazolium bromid mtt assay cytoplasm reactiv oxygen speci ros mitochondri transmembran potenti analyz flow cytometri use dichlorofluorescein diacet dcfh da rhodamin rho respect express glial fibrillari acid protein gfap voltag depend anion channel vdac measur western blot pilocarpin signific decreas cell viabil mitochondri potenti increas ros concentr signific time compar control nmp concentr gml protect astrocyt pilocarpin induc injuri concentr depend manner concomit nmp reduc cytoplasm ros accumul group treat gml nmp respect nmp also protect mitochondria pilocarpin induc depolar effect associ improv pilocarpin induc gfap vdac overexpress import biomark astrocyt dysfunct conclus improv ros accumul vdac overexpress mitochondri depolar possibl mechan nmp protect action reactiv astrocyt	D010862;D029632	T123;T121;T002;T109
36,350,973	whole blood circular rna hsacirc serv potenti diagnost biomark human adenovirus pneumonia children sever pneumonia relat human adenovirus hadv high lethal rate children earli diagnosi treatment remain major challeng circular rnas circrna novel long noncod rnas play import role gene regul diseas pathogenesi investig role circrna hadv pneumonia analyz circrna profil healthi children children hadv pneumonia includ mild sever case identifi signific upregul circrna children hadv pneumonia vs healthi control signific upregul circrna children sever hadv pneumonia vs mild hadv pneumonia particular hsacirc differenti express group might thus use diagnost biomark hadv pneumonia sever hadv pneumonia identifi under mechan circrna hadv pneumonia analyz transcriptom children hadv pneumonia establish circrna mrna regulatori network enrich analysi differenti express target mrnas demonstr differenti express gene healthi control hadv pneumonia patient main involv rna splice differenti express gene children mild sever hadv pneumonia main involv regul lymphocyt activ receiv oper characterist roc curv analysi suggest hsacirc signific valu diagnosi hadv pneumonia sever hadv pneumonia taken togeth circrna express profil alter children hadv pneumonia result demonstr hsacirc potenti diagnost biomark hadv pneumonia	D000260;D011014	T005;T050;T047
36,350,972	protect role raltegravir experiment acut lung injuri vitro vivo disrupt pulmonari endotheli permeabl associ barrier integr increas sever acut respiratori distress syndrom ard studi investig potenti abil human immunodefici virus hiv integras inhibitor raltegravir protect acut lung injuri ali under mechan accord impact raltegravir treatment vitro lipopolysaccharid lps stimul human pulmonari microvascular endotheli cell hpmec model ali vivo lps induc two hit ali rat model examin rat model system raltegravir treatment allevi ali associ histopatholog chang reduc microvascular permeabl decreas evan blue dye extravas suppress express inflammatori protein includ hmgb tlr p nf b nlrp mpo promot upregul protect protein includ claudin cadherin aquaporin measur via western blot immunohistochem stain confirm abil raltegravir treatment revers lps induc pulmonari chang nlrp claudin aquaporin express furthermor vitro analys hpmec reaffirm abil raltegravir attenu lps induc declin cadherin claudin express simultan inhibit nlrp activ reduc express hmgb tlr nf kb thus decreas overal vascular permeabl overal find suggest raltegravir may repres viabl approach treat experiment ali function maintain pulmonari microvascular integr	D024243;D055371	T123;T116;T037
36,350,971	higher frequenc anal dysplasia infect human papillomavirus crohn diseas patient aim studi compar frequenc dysplasia human papillomavirus hpv infect anal canal patient crohn diseas cd control group assess whether correl use immunosuppress anal manifest cd patient cd control individu submit anal cytolog materi collect polymeras chain reaction pcr cytolog classifi normal atyp squamous cell undetermin signific ascus low grade squamous intraepitheli lesion lsil high grade hsil pcr consid posit negat accord virus presenc absenc total patient includ control group cd group without immunosuppress ascus lsil found control patient cd patient hpv identifi control group cd group cd patient hpv found without immunosuppress respect patient perian involv pcr posit statist differ dysplasia infect hpv group use immunosuppress influenc result anal manifest invers proport viral detect	D030361;D052685;D065309;D003424;D001005;D002583	T025;T191;T033;T005;T047
36,350,970	valid onlin predict tool cohort earli breast cancer brazil predict tool design estim benefit adjuv therapi overal surviv women earli breast cancer model use clinic histolog immunohistochem variabl studi aim evalu model perform brazilian popul assess discrimin calibr predict model estim overal surviv os five ten year follow cohort women earli breast cancer diagnos januari decemb total patient estrogen receptor er posit er negat tumor area receiv oper characterist roc curv auc discrimin ci five year ci ten year women er posit tumor auc ci five year ci ten year women er negat tumor predict surviv er posit tumor ci five year ci ten year observ surviv ci ci respect predict surviv er negat tumor ci five year ci ten year observ surviv ci ci respect conclus predict accur estim os women er posit tumor overestim os women er negat tumor	D001943	T191
36,350,969	allogen hematopoiet stem cell transplant children adolesc ethic problem face multidisciplinari team identifi ethic problem face multidisciplinari team allogen hematopoiet stem cell transplant children adolesc	D010166;D018380	T061
36,350,968	construct valid mobil applic health educ covid construct valid mobil applic health educ covid	D063731;D000086382	T047;T170;T067
36,350,967	assess women satisfact labor childbirth teach hospit assess satisfact puerper women regard labor childbirth	D010549;D017060	T033;T041;T080
36,350,966	spatiotempor pattern factor relat childhood tuberculosi identifi spatiotempor pattern childhood tuberculosi sociodemograph factor relat	D014376	T047
36,350,965	risk manag advers event matern hospit investig root caus advers event matern hospit risk manag	D006771;D012308	T058;T093
36,350,964	absente nurs nurs technician urgenc emerg unit associ absente nurs nurs technician work environ urgenc emerg care unit	D000041;D009741	T055;T097
36,350,963	effect mobil applic use knowledg human immunodefici virus among univers student evalu effect use mobil applic knowledg human immunodefici virus among univers student	D063731;D000163;D015658	T047;T170
36,350,962	factor associ presente outpati nurs profession analyz sociodemograph work health profil nurs profession work univers outpati clinic associ presente	D000069597;D010045	T101;T091
36,350,961	cross cultur adapt valid instrument measur nurs care depend cross cultur adapt valid iniciar instrument use brazil	D003431;D014177	T062;T170
36,350,960	central steril servic depart screen autom clean liposuct cannula evalu effect autom clean mm liposuct cannula use ultrason washer machin screen dirt use cannul microscop devic screen viabl strain staphylococcus aureus microbiolog analysi	D015187	T061
36,350,959	earli incision hernia liver transplant risk factor hernia repair result liver transplant complex valuabl therapi howev complic burden postop qualiti life incision hernia better elucid risk factor prophylact measur	D000069290;D016031;D006528;D008113;D006555	T061;T046;T191;T190
36,350,954	brazilian thorac associ recommend long term home oxygen therapi chronic respiratori diseas caus hypoxemia case long term home oxygen therapi ltot indic treatment option primarili improv patient qualiti life life expect home oxygen use year support ltot base two studi demonstr oxygen use improv surviv patient copd evid ltot benefici effect improv cognit function improv exercis capac reduc hospit ltot indic respiratori diseas caus hypoxemia basi criteria use copd increas use ltot probabl increas life expect higher preval chronic respiratori diseas well greater avail ltot health care system first brazilian thorac associ consensus statement ltot publish twenti two year later present updat version document nonsystemat review literatur conduct pulmonologist evalu scientif evid intern guidelin ltot various diseas caus hypoxemia specif situat ie exercis sleep air travel recommend produc view clinic practic contain sever chart inform indic ltot oxygen sourc accessori strategi improv effici effect recommend safe use ltot well ltot prescrib model	D011788;D029424	T078;T047
36,350,953	genet polymorph effect sever silicosi worker expos silica brazil silicosi pneumoconiosi character fibrosi lung parenchyma caus inhal silica particl genet factor might play role sever silicosi sought evalu influenc polymorph ace fas faslg nos ilrn fama tgfb tnf gene sever silicosi	D012822;D012829	T197;T047
36,350,952	lung cancer screen low dose ct integr pulmonari care public hospit southern brazil result first patient describ perform pulmonologist led lung cancer screen program use low dose ct ldct cohort outpati stabl respiratori diseas brazilian public health care system	D008175	T191
36,350,951	covid knowledg attitud practic among health care worker latin america evalu covid knowledg attitud practic among health care worker hcws practic latin american countri first surg covid pandem	D000086382	T047;T067
36,350,950	phytochemistri allelopathi anticanc potenti withania somnifera l dunal solanacea withania somnifera wild plant show great activ safeti sever human diseas current research explor plant chemic composit allelopath effect rumex dentatus recipi plant moreov anticanc activ also test four type human cancer cell line chemic analysi w somnifera show high percentag saponin tannin glycosid alkaloid flavonoid occur second order result allelopath experi reveal signific inhibit r dentatus plumul radicl length well relat dri weight addit signific reduct primari metabolit r dentatus like non reduc total sugar well solubl protein determin cytotox potenti w somnifera also prove four differ cancer line name human hepatocellular carcinoma cell line hepg human non small cell lung cancer cell line human breast cancer cell line mcf colon cancer cell line caco ic valu gml respect	D032341;D019657;D002289;D008175	T191;T002
36,350,949	foul resist investig seawe product solid unprotect undefend surfac aquat environ foul foul hand affect wide rang speci toler epibiosi sever other hand aggress keep epibiont bodi surfac antifoul antifoul defens built marin plant like seawe seagrass distinct surfac structur tight pack needl like peak antifoul cover may hinder settl bacteria abil cling chemic antifoul resist probabl biolog reaction epibiosi ecolog drawback especi organ capabl perform photosynthesi goal studi see effect natur compound deriv littor seawe prevent foul brown mussel import foul organ evalu laboratori bioassay fifti one popul crude organ extract includ fort two macroalga speci antifoul activ exhibit distinct phylogenet pattern red macroalga largest share activ speci subsequ brown macroalga antifoul action green seawe never signific seven speci show level induc antifoul defens find appear back previous find secondari metabolit synthesi seawe indic hunt novel antifoul research concentr effort tropic red macroalga	D012624;D049872	T204
36,350,948	occurr densiti mollusc speci differ area basrah provinc southern iraq first record invas golden mussel limnoperna fortunei dunker studi conduct compar distribut composit mollusc communiti ecosystem site southern iraq name site euphrat river al madinah citi site shatt al arab al sharsh area site garmat ali river al mashib area site al seba area sampl collect studi site period januari august speci class gastropoda speci class bivalv speci predomin studi month speci melenodi nodosa bellamya bengalensi melanopsi turbculata gastropoda two speci bivalv corbicula fluminali limnoperna fortunei dunker last speci l fortunei record current studi first time freshwat iraq total biodivers valu mollusc euphrat river al madinah area site al sharsh area site al mashib area site al seba area site respect note highest season densiti speci current studi record winter season reach individu four site respect	D049879;D049851	T204
36,350,947	associ tinnitus self report system arteri hypertens retrospect studi describ data hear loss system arteri hypertens tinnitus individu verifi associ self report system arteri hypertens tinnitus well correl variabl present sampl hear loss tinnitus age tinnitus age system arteri hypertens	D014012;D034381;D006973;D003638	T033;T184;T047;T037
36,350,946	major advers cardiovascular event caus mortal emerg general surgeri among kidney failur patient emerg general surgeri eg associ increas mortal kidney failur contribut risk compar outcom patient kidney failur general popul lack	D051437;D002318	T047
36,350,945	associ biopsychosoci factor self report covid clinic complic brazilian citi studi aim analyz exist associ biopsychosoci profil peopl affect number self report clinic complic covid brazilian citi	D000086382	T047;T067
36,350,944	evalu antibacteri properti shear bond strength orthodont composit contain silver nanoparticl titanium dioxid nanoparticl fluorid vitro studi studi aim determin antibacteri properti composit contain silver nanoparticl ag nps titanium dioxid nanoparticl tio nps fluorid releas composit streptococcus mutan lactobacillus acidophilus evalu effect shear bond strength sbs nanoparticl modifi composit	D053768;D016910	T074;T073
36,350,943	efficaci product bleach whiten orthodont bracket mani patient wear orthodont applianc request alter shade teeth orthodont treatment	D016910;D058205;D014073	T061;T074;T167
36,350,942	extern apic root resorpt orthodont treatment analysi differ chronolog period extern apic root resorpt earr character definit loss tooth root structur higher incid later central maxillari incisor	D012391	T047
36,350,941	biochem physiolog growth evalu differ chickpea genotyp vari salin regim biochem physiolog paramet growth yield field crop especi salt sensit crop like chickpea affect advers salin arid semi arid region investig effect differ salin level growth biochem physiolog paramet chickpea genotyp pot experi follow crd two factor factori design conduct glasshous institut biotechnolog genet engin univers agricultur peshawar pakistan ten kg soil fill pot salin level maintain mm nacl mm nacl mm nacl mm appli nacl genotyp chickpea kk bhakkar bittl punjab cm use crop matur growth paramet physiolog biochem ionic paramet measur use standard analysi procedur salin reduc growth yield genotyp rate decreas differ among genotyp test result decreas k concentr kna ratio transpir rate stomat conduct n p observ genotyp increas salin increas salin level increas prolin content crude protein ho lipid peroxid carbohydr na concentr highest level salin mm nacl exhibit highest salin stress paramet genotyp kk bhakkar show lower rate relat decreas yield kna ratio k concentr respect lowest relat increas na accumul mm salin compar control genotyp kk bhakkar prove better mm salin find suggest critic level salin must kept mind salt toler genotyp cultiv salt affect soil	D054712;D029863	T168;T034;T002
36,350,940	studi integu cover back stinger freshwat stingray potamotrygon rex chondricthy potamotrygonida object studi describ histolog histochemistri integu cover back stinger freshwat stingray potamotrygon rex endem middl upper tocantin river speci dark back yellowish circular spot extend tail one two sting locat median portion tail histolog studi observ epithelia back stinger compos non keratin stratifi pavement epitheli tissu organ three layer basal intermedi superfici differ tissu relat cell type compos back organ epitheli cell mucus cell granulocyt cell chromatophor mucus cell distribut differ layer along anim back influenc thick tissu tissu cover stinger compos epitheli cell chromatophor special cell protein synthesi histochemistri stinger epitheli cell stain bromophenol blue especi intermedi layer call special cell back epitheli cell stain bromophenol blue alcian blue pas mucous cell pas tissu presenc protein reserv detect area call stain strong bromophenol blue result show stinger present activ direct product protein back organ produc differ compon constitut cuticl cover anim bodi	D012860;D001733	T037;T013
36,350,939	socioeconom aspect profil fish accord fisher commerci edibl fish municip barcelo middl negro river amazona brazil fish play promin role socioeconom scope negro river basin consid one main extract activ region object studi describ socioeconom aspect commerci fisher edibl fish work municip barcelo middl negro river region well highlight scenario fish activ point view fisher inform collect januari decemb municip barcelo state amazona via semi structur questionnair interviewe male age year mean age year low level educ incomplet elementari educ illiter fish tackl use fishermen gillnet especi urban fishermen among fish site main one demeni river commerci fish edibl fish barcelo focus characiform perciform siluriform fish main difficulti face activ relat season level river local tributari well lack buyer low sell price fish addit conflict use fish resourc commerci fish edibl fish activ great socioeconom import riversid famili middl river negro basin need greater attent public author therefor expect inform contain studi help decis make process manag local fisheri resourc contribut resumpt growth sustain commerci edibl fish fisheri	D045483;D003247	T078;T070;T069;T081;T064
36,350,938	resist sorghum hybrid sorghum aphid aphid melanaphi sorghi theobald hemiptera aphidida infest sorghum crop econom import pest caus sever damag sorghum crop brazil sinc speci observ main end veget stage begin reproduct stage plant high reproduct rate sorghum rais concern pest therefor present studi aim estim life expect fertil tabl melanaphi sorghi fed hybrid grain sorghum order know resist characterist materi understand plant resist help manag insect studi carri laboratori c rh relat humid fifti insect kept hybrid insect consid one repetit accord biolog paramet fertil life tabl hybrid brs dkb less suitabl sugarcan aphid multipl thus hybrid could use manag pest sinc popul growth speed one worst problem implement crop system genotyp ag msk xgn favor develop pest chosen within crop system manag strategi consid	D001042;D045868	T002;T204
36,350,936	afrosymetr method quantifi saponin chenopodium quinoa willd colombia quinoa chenopodium quinoa willd pseudocer addit present good nutrit characterist grain secondari metabolit episperm seed within saponin saponin character emulsifi foam generat bitter tast metabolit complet studi quinoa materi colombia reason object research quantifi content saponin present quinoa materi depart boyac use three afrosimetr method complet random design crd implement factori arrang afrosimetr method x quinoa materi quantif saponin determin amarilla de marangan genotyp one present highest content evalu method standard afrosimetr method effici final conglomer analysi allow discrimin materi sweet quinoa tunkahuan blanca de jeric saponin content lower bitter quinoa negra de la colorada dorada amarilla de marangan content higher biochem character germplasm allow select genotyp suitabl consumpt industri given potenti use saponin current	D027465;D012503	T168;T002;T109
36,350,935	express analysi phosphat induc gene contrast maiz genotyp phosphorus use effici phosphorus essenti nutrient plant growth develop abil plant acquir phosphat pi rhizospher soil critic brazilian cerrado character acid soil induct pi transport one earliest molecular respons pi defici plant studi character transcript regul six zmpt zmpt high affin pi transport gene four pi effici four pi ineffici maiz zea may genotyp express analysi indic pi starvat induc transcript zmpt gene test abund transcript invers relat pi concentr nutrient solut observ earli five day follow pi depriv pi starv plant replenish pi four five day result zmpt suppress indic pi role gene express tissu specif express analysi reveal abund zmpt transcript root shoot six maiz pi transport primarili detect upper middl root portion bare express root tip express profil six zmpts phosphat transport among pi effici pi ineffici genotyp show absenc signific differ express pattern zmpts among pi effici pi ineffici genotyp result suggest pi acquisit effici complex trait determin quantit loci maiz	D003313;D010710	T168;T197;T002
36,350,927	ocular manifest monkeypox case report monkeypox diseas viral zoonosi symptom similar seen past smallpox variola although clinic less sever follow erad smallpox subsequ cessat smallpox vaccin monkeypox emerg import orthopoxvirus public health standpoint monkeypox virus occur primarili central western africa often tropic forest increas manifest urban area anim host includ various rodent nonhuman primat report case patient monkeypox diseas develop ocular complaint eye discomfort conjunct detect conjunctiv lesion biomicroscopi fluorescein test ophthalmolog manifest still poor known	D045908;D012899	T047
36,350,926	microbi effect prebiot probiot synbiot caesarean section exposur antibiot first week life systemat review disrupt develop microbiota caesarean birth earli exposur antibiot may impact long term health outcom potenti prevent nutrit supplement systemat review aim summaris evid regard effect prebiot probiot synbiot intestin microbiota composit term infant born caesarean section expos antibiot first week life	D058616;D019936	T168;T007
36,350,925	impact covid pandem earli career dementia research global onlin survey world health organ recogn dementia public health prioriti highlight research action respond consequ earli career dementia research ecdr repres key drive forc due covid pandem howev biomed psychosoci dementia research strain worldwid aim studi understand impact pandem ecdr	D000086382;D000544;D061108	T047;T170;T067;T048
36,350,924	health inform covid vaccin belief attitud among japanes univers student coronavirus diseas covid vaccin adolesc young adult import infect control factor influenc vaccin behavior age group includ sourc inform vaccin social norm howev studi factor influenc vaccin behavior among japanes univers student studi aim assess belief attitud sourc inform covid vaccin among univers student japan cross section onlin questionnair survey conduct among student teikyo univers japan septemb survey design collect demograph inform vaccin status attitud belief anxieti vaccin sourc inform whether particip watch educ movi factor associ belief attitud analyz use logist linear regress total valid questionnair retriev posit vaccin behavior group includ student common sourc inform covid vaccin tvradio common social network servic sns covid inform twitter approxim student believ efficaci vaccin posit attitud associ femal sex watch educ movi univers concern vaccin posit associ inform acquaint instagram negat associ inform twitter watch educ movi major student posit belief attitud toward covid vaccin social media educ movi produc univers larg influenc attitud toward vaccin behavior contrari student anxious vaccin promot educ movi social media univers effect way encourag vaccin among young peopl	D000086382;D014612	T129;T121;T116;T067;T047
36,350,923	integr gene analys de novo variant trio autism development disord genet studi consid autism spectrum disord asd development disord dd separ despit overwhelm comorbid share genet etiolog analyz de novo variant dnvs asd spark dd trio independ also combin broader neurodevelopment disord ndds use three model identifi ndd candid gene fals discoveri rate fdr support model includ reach bonferroni exom wide signific p e model gene group five function network associ differ brain development lineag base singl cell nuclei transcriptom data find evid asd specif gene contrast gene signific enrich dd gene show mutat bias includ enrich missens n truncat n dnvs also find gene evid male femal bias enrich includ x chromosom gene signific femal burden ddxx mecp wdr hdac larg scale integr analysi identifi candid function subset ndd gene	D001321;D000067877	T048
36,350,921	host circadian behavior exert weak select pressur gut microbiom stabl condit critic recoveri antibiot treatment circadian rhythm host dictat approxim h transform environ experienc gut microbiom consequ cyclic environ intestin microbiota bare understood like medic ramif daili rhythmic gut act select pressur shape microbi communiti moreov given sever bacteri speci report exhibit circadian rhythm test whether rhythmic environ select pressur favor clock harbor bacteria anticip prepar consist daili chang environ observ daili rhythmic mous gut environ stabil influenc facilit microbiot recoveri antibiot perturb composit microbiom recov pretreat condit expos consist daili rhythmic wherea host whose feed activ pattern tempor disrupt microbiot recoveri incomplet allow potenti unhealthi opportunist exploit tempor disarray unexpect found absenc antibiot perturb gut microbiom stabl rhythmic versus disrupt feed activ pattern comparison result studi reveal intrigu correl stabl microbiom may resili one perturb alon eg disrupt daili time host behavior feed multipl perturb combin howev perturb stabl microbiom regular daili pattern host behaviorfeed appear essenti microbiom recov origin steadi state given inconsist daili rhythm modern human life eg shiftwork social jet lag irregular eat habit result emphas import consist daili rhythmic optim health direct host also indirect preserv host microbiom face perturb	D000069196;D064307	T032;T007;T028;T001
36,350,920	reason mental state uncertainti theori mind tom abil infer mental state other integr facilit healthi social interact peopl reason mental state other even limit sometim inconsist inform howev littl known peopl make infer mental state other uncertainti featur inform import aid mental state reason current studi conduct three uniqu experi alter particip uncertainti engag tom test experi simultan manipul amount consist inform avail social stimuli present particip experi aim deciph featur social stimuli conduc mental state reason experi manipul amount inform avail particip experi manipul consist inform avail particip use frequentist bayesian statist result confirm manipul amount consist inform alter tom perform exploratori analysi compar effect amount consist inform suggest effect consist inform seem stronger amount inform taken togeth three experi suggest amount consist inform import featur social stimuli consist inform avail salient infer mental state other find discuss relat inform theori import implic creat enrich social stimuli may enhanc mental state reason individu social deficit	D056345	T078
36,350,919	privaci assur work studi truth healthcar histori data collect patient often provid untruth inform health avoid embarrass evad treatment prevent financi loss privaci disclosur eg hipaa intend dissuad privaci concern may actual increas patient lie use new mous track base technolog detect lie mous movement distanc time respons patient answer adjust onlin control studi potenti patient random assign one six treatment treatment differ notic patient receiv health inform request includ notic privaci benefit truth disclosur risk inaccur disclosur increas time distanc devic mous movement greater adjust answer indic less truth mous track reveal signific overal effect p lt treatment time reach final choic control took least time indic greater truth privaci risk group took longest indic least truth privaci risk benefit disclosur statement led greater lie differ moder gender mous track result larg confirm answer adjust lie detect method overal treatment effect p lt gender differ p lt truth privaci notic led decreas patient honesti privaci notic perhap administ well person health disclosur request minim patient untruth mous track answer adjust appear health care lie detect method enhanc optim diagnosi treatment	D018907;D003219	T033;T078;T089;T170
36,350,899	experi particip clinic trial novel radioact treatment advanc prostat cancer nest qualit longitudin studi qualit studi nest within clinic trial provid insight treatment experi evolv time improv support care requir purpos qualit studi describ live experi men advanc prostat cancer particip therap trial randomis trial lu psma compar cabazitaxel chemotherapi	D011471	T191
36,350,898	evalu use semi structur crowdsourc data quantifi inequit access urban biodivers case studi ebird credibl estim social ecolog relationship requir data broad coverag fine geograph resolut typic avail standard ecolog survey open unstructur data crowdsourc platform offer opportun collect larg quantiti user submit ecolog data howev repres area sampl data portal well known investig data avail ebird one largest popular crowdsourc scienc platform correl race incom census tract two citi boston phoenix az find checklist submiss vari great across census tract similar pattern within metropolitan region particular census tract high incom high proport white resid like repres data citi indic select bias ebird coverag result illustr non repres ebird data also rais deeper question valid statist infer regard dispar drawn dataset discuss challeng illustr sampl select problem unstructur semi structur crowdsourc data lead spurious conclus regard relationship race incom access urban bird biodivers crowdsourc data indispens complementari tradit approach collect ecolog data conclud unstructur semi structur data may well suit line inquiri particular requir consist data coverag thus handl appropri care	D063045	T062;T170
36,350,897	structur base virtual screen molecular dynam potenti inhibitor target sodium bile acid co transport carcinogen liver fluke clonorchi sinensi clonorchi sinensi requir bile acid transport fluke inhabit bile juic fill biliari duct provid extrem environ clonorchi sinensi sodium bile acid co transport cssbat indispens fluke surviv final host circul taurochol prevent bile toxic fluke henc recogn use drug target	D003004;D005210;D003003;D027981	T123;T047;T116;T204
36,350,896	protocol isistaquit implement phase support indigen smoker assist quit project aborigin andor torr strait island women smoke pregnanc compar general popul counterpart evid base quit smoke advic receiv health care profession hcps increas smoke cessat rate howev hcps lack cultur appropri smoke cessat train major barrier provis smoke cessat care popul	D016540;D006303	T055;T058

36,351,367

satellit glia adult dorsal root ganglia harbor stem cell yield glia physiolog condit neuron respons injuri presenc putat stemprogenitor cell suggest adult peripher nervous system pns tissu includ dorsal root ganglion drg date identif fate pathophysiolog condit address combin multipl vitro vivo approach identifi presenc stem cell adult drg satellit glial popul progenitor present drgs sciatic nerv cell specif transgen mous line highlight prolif potenti drg stem cell progenitor vitro drg stem cell gliogen neurogen potenti wherea progenitor essenti gliogen lineag trace show physiolog condit adult drg stem cell maintain drg homeostasi suppli satellit glia patholog condit adult drg stem cell replac drg neuron lost injuri addit renew satellit glial pool novel find open new avenu develop therapeut strategi target drg stem cell pns disord

D005727;D053687

T023;T025

36,351,340

chang toward healthier lifestyl associ better health relat qualiti life long term colorect cancer survivor littl known chang constel lifestyl factor affect health relat qualiti life hrqol colorect cancer crc survivor studi aim investig associ chang healthi lifestyl hrqol time survivor stage iv crc

D011788;D015179

T078;T191

36,351,338

healthcar access dimens guidelin concord ovarian cancer treatment seer medicar analysi orchid studi racial dispar exist receipt guidelin concord treatment ovarian cancer oc howev studi evalu various dimens healthcar access hca contribut dispar

D044465;D010051

T098;T191

36,351,336

associ frailti time aliv home cancer surgeri among older adult popul base analysi although frailti known impact short term postop outcom long term impact unknown studi examin associ frailti remain aliv home cancer surgeri among older adult

D000073496;D009369

T033;T184;T046;T191

36,351,335

nccn guidelin insight gastrointestin stromal tumor version gastrointestin stromal tumor gist common type soft tissu sarcoma occur throughout gastrointestin tract tumor caus oncogen activ mutat kit pdgfra gene nccn guidelin gist provid recommend diagnosi evalu treatment follow patient tumor nccn guidelin insight summar panel discuss behind recent import updat guidelin includ revis system therapi option unresect progress metastat gist base mutat status updat recommend manag gist develop resist specif tyrosin kinas inhibitor

D046152

T191

36,351,334

pediatr aggress matur b cell lymphoma version nccn clinic practic guidelin oncolog nccn clinic practic guidelin oncolog nccn guidelin pediatr aggress matur b cell lymphoma includ recommend diagnosi manag pediatr patient primari mediastin larg b cell lymphoma pmbl sporad variant burkitt lymphoma diffus larg b cell lymphoma pmbl consid distinct entiti aris matur thymic b cell account matur b cell lymphoma children adolesc discuss section includ recommend outlin nccn guidelin diagnosi manag pediatr patient pmbl

D016403

T191

36,351,333

brafmek dual inhibitor therapi progress anaplast pleomorph xanthoastrocytoma case seri literatur review recurr anaplast pleomorph xanthoastrocytoma r apxa rare primari brain tumor challeng treat two third pxa tumor harbor braf gene mutat braf inhibitor shown improv tumor control howev resist braf inhibit develop case concurr therapi mek inhibitor may improv tumor control patient surviv studi identifi patient diagnos braf mutat pxa receiv braf mek inhibitor year interv institut patient record evalu includ treatment advers effect ae outcom patholog next generat sequenc mri median age year rang year male anaplast pxa median overal surviv month rang month patient die tumor relat hemorrhag therapi experienc long term diseas control month respect dual brafmek inhibitor well toler grade ae includ rash neutropenia fatigu abdomin discomfort diarrhea grade ae detect literatur review also perform patient diagnos braf mutat pxa treat braf andor mek inhibitor august total case identifi median age year rang year median pfs os month rang month month rang month respect common ae grade fatigu skin rash result case seri literatur review indic dual drug therapi braf mek inhibitor r apxa braf mutat may delay tumor progress without unexpect ae

D001932;D001254

T191

36,351,332

paid sick leav among work cancer survivor associ use prevent servic unit state sought examin lack paid sick leav among work cancer survivor sociodemographicsocioeconom employ characterist associ prevent servic use unit state

D000073116;D009369

T201;T191;T101

36,351,331

associ cancer center accredit complianc price disclosur common oncolog surgic procedur cancer center accredit status predic sever factor measur high valu healthcar howev price transpar critic healthcar decis qualiti measur includ accredit report rate price disclosur surgic procedur cancer breast lung cutan melanoma colon prostat among hospit rank american colleg surgeon commiss cancer ac coc

D008545;D001943;D012878

T191

36,351,330

incid cancer detect multipl wave covid tsunami earthquak popul base studi exist demonstr full spectrum impact covid hinder incid cancer detect larg cancer system build upon previous public jnccn conduct updat analysi use month new data accru pandem era extend studi period septemb octob demonstr multipl covid wave affect week cancer incid volum ontario canada fulli clear backlog end wave

D000086382;D055866;D009369

T047;T070;T191;T067

36,351,324

cpt mediat ioniz radiat induc intestin injuri prolifer via shift fao metabol pathway activ erk jnk pathway intestin compensatori prolif potenti key influenc factor suscept radiat induc intestin injuri studi indic carnitin palmitoyltransferas cpt mediat fatti acid oxid fao play crucial role promot surviv prolifer tumor cell aim explor effect co gamma ray cpt mediat fao radiat induc intestin injuri model investig role cpt mediat fao surviv prolifer intestin cell irradi detect chang fao plasma small intestin spragu dawley sd rat h co gamma irradi gy use target metabolom qrt pcr immunohistochemistri ihc western blot wb relat enzymat activ kit analyz fao chang radiat induc intestin injuri model regardless ex vivo mice enteroid vitro normal human intestin epitheli cell line hiec hiec cell transduc lentivirus vector gv treat puromycin obtain cpt stabl knockout cell line name cpt ko cpt enzymat activ hiec cell mice enteroid also inhibit pharmaceut inhibitor st etomoxir eto studi function cpt surviv prolifer hiec cell co gamma irradi found cpt mediat fao alter small intestin sd rat irradi especi express level enzymat activ cpt signific increas similar express level cpt also remark enhanc mice enteroid hiec cell irradi cpt inhibit decreas prolifer hiec cell mice enteroid irradi partial reduc extracellular signal regul kinas erk c jun n termin kinas jnk pathway activ cpt inhibit also reduc prolifer mice enteroid irradi partial regul wnt catenin signal activ conclus studi indic cpt play crucial role promot intestin epitheli cell prolifer irradi

D002334;D020935

T126;T116;T044

36,351,222

singl side deaf emot social handicap impact health status qualiti life function hear effect cochlear implant evalu function subject outcom individu singl side deaf ssd treat cochlear implant ci

D019929;D014012;D046088;D013067;D003054;D003638

T061;T184;T033;T037;T047;T074;T041

36,351,213

diffus larg b cell lymphoma chile impact combin chop plus rituximab public health system diffus larg b cell lymphoma dlbcl common lymphoma subtyp purpos studi evalu clinic featur prognost factor result dlbcl treat cancer center public health system chile compar cyclophosphamid doxorubicin vincristin prednison chop rituximab cyclophosphamid doxorubicin vincristin prednison r chop

D015658;D016403

T047;T191

36,351,212

impact covid pandem cancer stage analysi patient breast cancer communiti practic brazil nationwid lockdown enforc brazil start march covid pandem cancer screen activ reduc studi evalu impact covid pandem breast cancer bc diagnosi

D001943;D000086382

T047;T191;T067

36,351,211

real world evid health outcom relat lung stereotact bodi radiat therapi brazil stereotact bodi radiat therapi sbrt effect option patient earli stage oligometastat non small cell lung cancer nsclc howev data latin america limit therefor aim studi investig real world outcom appli sbrt lung lesion brazilian institut

D016634;D002289;D008175

T061;T191

36,351,203

post fire dynam tree veget forest without histori select log eastern amazon worldwid forest suscept fire forest fire select log interact requir monitor evalu studi evalu phytosociolog dynam tree veget disturb forest df undisturb forest uf select log area affect fire brazilian east amazon tree dbh cm measur identifi botan plot x df area plot x uf area log two year fire analysi speci tree composit divers similar mortal recruit carri fire affect df uf area similar proport term tree loss basal area intensifi mortal rate short term year fire caus signific reduct speci divers tendenc toward similar loss speci composit area disturb log subsequ assess necessari understand forest recoveri mechan

D014197;D005390

T067;T002

36,351,202

algorithm colinear chain overlap gap cost colinear chain proven power heurist find near optim align long dna sequenc eg long read genom assembl refer use intermedi step sever align tool employ seed chain extend strategi despit popular effici subquadrat time algorithm general case chain support anchor overlap gap cost current known present algorithm solv colinear chain problem anchor overlap gap cost n time n denot count anchor degre polylogarithm factor depend type anchor use eg fix length anchor type preced optim anchor chain requir satisfi also establish first theoret connect colinear chain cost edit distanc specif prove fix set anchor care design chain cost function optim anchor edit distanc equal optim colinear chain cost anchor edit distanc two sequenc set anchor slight general standard edit distanc add addit cost one align two match symbol support anchor final demonstr experiment optim colinear chain cost propos cost function comput order magnitud faster edit distanc achiev correl coeffici edit distanc close well distant relat sequenc

D000465

T170

36,351,192

ultrasound guid templ filler inject templ filler volum signific improv facial balanc appear signific risk includ contour irregular vascular occlus skin necrosi hair loss blind stroke nonthrombot pulmonari embol improv safeti precis templ volum introduc ultrasound guid inject hyaluron acid filler use interfasci space target filler placement review relev anatomi includ figur describ techniqu ultrasound guid filler inject interfasci plane real time visual cannula filler deposit includ detail video procedur

D003357

T061

36,351,187

miss part vital inform abstract avail

D014799

T078

36,351,186

compar cross section studi phasic heart rate variabl work memori among young adult heart rate variabl hrv could promis earli biomark cognit impair better understand reaction pattern cardiovascular cognit function help predict prevent manifest diseas addit benefici cardiovascular evid yoga promis lack short term approxim one year cross section investig

D008570;D001341

T022;T041

36,351,185

effect yoga psycholog health sleep qualiti patient acut insomnia preliminari studi insomnia poor sleep qualiti associ impair physic psycholog mental function individu requir health well

D015013;D007319;D019122;D012893

T061;T184;T047;T041;T048

36,351,094

adolesc nurs consult import excerpt care provid nurs brazilian state care adolesc without chronic diseas must complet standard focus individu demand transit process adult care adher treatment studi aim character care provid nurs state paulo work adolesc

D009732;D009726

T058;T097

36,351,093

nurs health care gay adolesc analyz nurs statement health care gay adolesc

D000072339;D012749;D009726

T047;T098;T097

36,351,092

manag overweight obes children adolesc nurs mix method studi analyz manag overweight obes children adolesc nurs famili health strategi

D050177;D063766

T033;T047

36,351,091

exclus breastfeed abandon adolesc mother cohort studi within health primari servic analyz factor associ abandon exclus breastfeed adolesc mother first month infant life

D001942;D000088662

T055;T099;T040;T102;T058

36,351,090

associ health literaci covid threat vaccin intent among brazilian adolesc investig influenc health literaci assess covid threat health intent vaccin among brazilian adolesc

D057220;D000086382

T047;T067;T041

36,351,089

health inequ among homeless adolesc highlight health inequ homeless adolesc base conceptu framework social determin health

D006297;D006703

T033;T098;T095;T080

36,351,088

biograph ruptur covid pandem adolesc young tran men transmasculin peopl demand nurs understand biograph ruptur caus covid pandem adolesc young tran men transmasculin peopl brazilian context

D058873;D000086382

T047;T067

36,351,087

emot behavior problem adolesc context covid mix method studi estim preval emot behavior problem adolesc context covid pandem e explor adolesc percept emot behavior problem identifi

D000066553;D000086382;D000294

T067;T055;T033;T047;T048

36,351,086

prevent non suicid self injuri construct valid educ materi develop valid educ materi strengthen adolesc health care non suicid self injuri

D016728

T055

36,351,085

adolesc understand chemotherapi relat advers event concept elicit studi document adolesc understand chemotherapi relat core advers event pediatr patient report outcom version common terminolog criteria advers event thus begin valid process tool item brazilian adolesc

D000071066;D009369

T170;T191

36,351,070

patient safeti cultur incid record nurs shift chang intens care unit analyz associ patient safeti cultur perceiv nurs profession incid record nurs shift intens care unit

D061214;D009728

T058;T097

36,351,069

incid risk factor postintens care syndrom cohort critic ill patient determin incid postintens care syndrom cohort critic ill patient admit intens care unit identifi risk factor relat develop physic cognit mental health area

D016638;D007362

T047;T073;T093

36,351,068

prognost valu peripher ischem microvascular reserv sepsi relat calcitonin gene relat peptid substanc p evalu mechan attribut prognost valu peripher ischem microvascular reserv patient sepsi

D006940;D018805;D009479

T123;T047;T046;T116

36,351,067

robust maintain emerg invas mechan ventil develop simpl robust safe effici invas mechan ventil use remot area world war zone practic util sophist equip limit consider maintain avail part transport andor cost

D012122;D045422

T061;T074

36,351,066

critic covid neurolog dysfunct direct compar analysi sar cov infecti pathogen evalu whether critic sar cov infect frequent associ sign corticospin tract dysfunct neurolog sign symptom syndrom infecti pathogen

D000086382;D009422;D012128

T047;T067

36,351,065

clinic outcom lung mechan characterist covid non covid associ acut respiratori distress syndrom propens score analysi two major random trial compar lung mechan outcom covid associ acut respiratori distress syndrom non covid associ acut respiratori distress syndrom

D000086382;D012128

T047;T067

36,351,064

autom document vital paramet ward use portabl station effect proper trigger rapid respons team studi protocol cluster random clinic trial evalu effect welch allyn connex spot monitorhillrom connecta solut activ rapid respons team time manner compar manual activ

D057209;D000086382

T058;T067;T097;T047

36,351,061

map venom stingray potamotrygon genus tiet river paulo sstate brazil freshwat stingray fish adapt river lake south america expans potamotrygonida famili paran river began dam sete queda fall reach mouth paranapanema tiet river approxim year ago via lock hydroelectr power plant aggress anim howev one four stinger tail cover venom produc epithelium caus sever envenom fishermen bather step manipul

D012860

T013

36,351,019

heighten apoptot prime vascular cell across tissu life span predispos cancer therapi induc toxic although major organ toxic frequent aris patient treat cytotox target cancer therapi mechan drive poor understood report vascular endotheli cell ec high prime apoptosi parenchym cell across mani adult tissu consequ ec readili undergo apoptosi respons mani common use anticanc agent includ cytotox target drug sensit ioniz radiat bh mimet parenchym cell vivo use differenti isogen human induc pluripot stem cell model ec vascular smooth muscl cell vsmcs find vascular cell exhibit distinct drug toxic pattern link diverg therapi induc vascular toxic patient collect result demonstr vascular cell high sensit apoptosi induc stress across life span may repres weakest link vulner multipl tissu develop toxic

D057026;D009369

T191;T025

36,351,018

dna replic initi shape mutat landscap express human genom interplay activ biolog process dna repair central mutagenesi show ubiquit process replic initi mutagen leav specif mutat footprint thousand earli effici replic origin observ mutat pattern consist two distinct mechan reflect two step process origin activ trigger format dna break center origin local error prone dna synthesi immedi vicin demonstr replic initi depend mutat process exert influenc phenotyp divers human disproportion origin genom size increas mutat load gene promot splice junction presenc origin signific influenc gene express mrna isoform usag last show mutagenesi origin drive evolut origin sequenc also contribut sculpt regulatori domain human genom

D015894;D004261

T045;T028

36,351,016

nitroreductas instruct supramolecular assembl microbiom regul enhanc colorect cancer treatment develop human microbiom collect correl sophist interact fusobacterium nucleatum colorect cancer crcs howev treatment crc via disrupt gastrointestin flora remain less explor aim regul activ nitroreductas f nucleatum infect tumor develop nitroreductas instruct supramolecular self assembl design assembl precursor underw enzymat transform form assembl agglutin f nucleatum erad target bacteria assembl anti f nucleatum activ could allevi bacteria induc drug resist effect thus sensit crc cell chemo drug eventu mice bear f nucleatum infect crc local introduct nitroreductas instruct assembl could effici inhibit tumor growth overal studi incorpor nitroreductas broaden toolbox enzym instruct supramolecular self assembl local introduct nitroreductas instruct assembl could target f nucleatum elimin contribut crc drug resist amelior chemotherapi outcom

D015179;D000069196

T191;T001;T007

36,351,009

identif minor popul lmo breast cancer cell integr vasculatur initi metastasi metastasi respons breast cancer relat death howev identifi cellular determin metastasi remain challeng identifi minor popul immatur thi vegfa tumor epitheli cell human breast tumor biopsi display angiogen featur mark express oncogen lmo higher abund lmo basal cell correl tumor endotheli content predict poor distant recurr free surviv patient use mmtv pymtlmocreert mice demonstr lmo lineag trace cell integr vasculatur higher propens metastas lmo knockdown human breast tumor reduc lung metastasi impair intravas lead reduc frequenc circul tumor cell mechanist find lmo bind stat requir stat activ tumor necrosi factor interleukin collect studi identifi popul metastasi initi cell angiogen featur establish lmo stat signal axi therapeut target breast cancer metastasi

D001943;D008175

T191

36,350,993

immun checkpoint therapi forg ahead spatiotempor immun monitor clinic trial revers translat help determin optim combin immun therapi cure cancer

D007167;D009369

T061;T191

36,350,992

next cancer vaccin cancer vaccin shown clinic drive tumor reactiv cell activ prolifer effector function unfortun tumor erad treatment cancer vaccin unsuccess mani patient critic step way improv vaccin efficaci combin immunotherapi standard care treatment

D019496;D009369

T129;T121;T191;T116

36,350,991

advanc beyond twist turn cell exhaust cancer chronic antigen stimul lead cell exhaust nutrient restrict suppress factor tumor microenviron exacerb cell dysfunct better understand heterogen dynam exhaust cd cell guid novel therapi modul cell differenti achiev effect antitumor respons

D018414;D009369

T191;T025

36,350,990

vivo gene immunotherapi cancer cancer becom increas understood diseas patholog cell also one immun hypofunct heterogen patient specif natur cancer underscor need person cellular therapi current produc ex vivo gene modul approach therapeut rnas improv viral vector bring us closer toward strategi mitig diseas particular diseas benefit alter gene transgen express profil patholog therapeut immun cell advanc toolbox technolog trend toward simplifi person therapi foreshadow opportun direct vivo precis medicin cancer

D007167;D009369

T061;T191

36,350,989

combin cancer immunotherapi emerg treatment strategi adapt tumor microenviron immun checkpoint blockad icb revolution cancer treatment howev resist icb occur frequent due tumor intrins alter extrins factor tumor microenviron viewpoint aim give updat recent develop immunotherapi solid tumor highlight progress translat research clinic practic

D059016;D009369

T070;T191

36,350,988

cd target cd bispecif antibodi enhanc antitumor efficaci odronextamab refractori diffus larg b cell lymphoma model although mani patient diffus larg b cell lymphoma dlbcl may achiev complet respons frontlin chemoimmunotherapi patient relapsedrefractori diseas typic poor outcom odronextamab cdxcd bispecif antibodi provid signal activ cell receptorcd complex exhibit earli promis activ patient high refractori dlbcl phase trial howev patient achiev complet respons mani relaps thus repres high unmet medic need investig whether ad costimulatori signal engag cd receptor cell could augment odronextamab activ demonstr regn bispecif antibodi cross link cd express tumor cell cd express cell enhanc odronextamab potenti cell activ cytolyt function preclin dlbcl studi use human immun system reconstitut anim regn promot antitumor activ odronextamab induc intratumor expans reprogramm cell skew away dysfunct state although regn monotherapi show limit activ toxic primat studi augment cell activ dose combin odronextamab addit analysi non hodgkin lymphoma clinic sampl reveal increas cd cd cell odronextamab treatment demonstr presenc popul could potenti target regn collect data demonstr regn mark enhanc antitumor activ odronextamab preclin nhl model combin two bispecif antibodi may provid chemotherapi free approach treatment dlbcl

D018033;D008228;D016403;D000970

T129;T121;T116;T109;T191

36,350,987

interleukin base therapi cancer molecular insight mechan benefici advers effect interleukin il result develop improv il formul il receptor bias tissu target properti sever compound current clinic develop usher il therapi current era cancer immunotherapi

D007376;D009369

T129;T121;T191;T116

36,350,986

blimp nra transcript factor reciproc regul antitumor car cell stem exhaust chimer antigen receptor car cell induc meaning clinic respons solid tumor loss cell stem poor expans capac exhaust prolong tumor antigen exposur major caus car cell therapeut resist singl cell rna sequenc analysi car cell first human trial metastat prostat cancer identifi two independ valid cell state associ antitumor potenc lack efficaci low express prdm encod blimp transcript factor defin high potent tcf encod cell factor tcf express cd car cell wherea enrich havcr encod cell immunoglobulin mucin domain contain tim express cd cell elev prdm associ poor outcom prdm knockout promot tcf depend car cell stem prolifer result margin enhanc leukemia control mice howev set prdm defici negat epigenet feedback program nuclear factor activ cell nfat driven cell dysfunct identifi program character compensatori regul nra gene encod exhaust relat transcript factor hamper cell effector function solid tumor dual knockout prdm nra skew car cell phenotyp away tim cd toward tcf cd counter exhaust tumor infiltr car cell improv antitumor respons effect achiev prdm nra singl knockout alon data underscor dual target prdm nra promis approach advanc adopt cell immuno oncotherapi

D009369;D011987

T191;T116;T192

36,350,985

translat evolv molecular landscap tumor biomark respons cancer immunotherapi immun checkpoint inhibitor ici revolution cancer therapeut trigger studi understand molecular cellular wire respons resist increas understand under biolog respons ici enabl investig tumor intrins extrins featur may predict therapeut outcom parallel liquid biopsi measur circul tumor dna ctdna use assess real time molecular respons guid clinic decis ici combin approach provid deeper understand cancer biolog immunoedit evolut ici promis extend util immunotherapi patient cancer

D009369;D000074141

T191;T114

36,350,984

pool screen car cell identifi divers immun signal domain next generat immunotherapi chimer antigen receptor car repurpos natur signal compon retarget cell refractori cancer shown limit efficaci persist recurr malign introduc car pool multiplex approach rapid identifi car design clinic potenti forti car signal domain deriv rang immun cell lineag evalu pool assay abil stimul critic cell effector function repetit stimul mimic long term tumor antigen exposur sever domain identifi tumor necrosi factor tnf receptor famili primarili associ b cell cd enhanc prolifer wherea b cell activ factor receptor baff r transmembran activ caml interactor taci promot cytotox function enhanc relat clinic benchmark prolong antigen stimul car cell signal domain fell distinct state memori cytotox metabol baff r car cell enrich high cytotox transcript signatur previous associ posit clinic outcom also observ replac bb intracellular signal domain baff r signal domain clinic valid b cell matur antigen bcma specif car result enhanc activ xenotranspl model multipl myeloma togeth result show car pool general approach rapid explor car architectur activ improv efficaci car cell therapi

D009364;D000076962

T129;T191;T116;T192

36,350,974

n methyl r tran hydroxi l prolin major bioactiv compound sideroxylon obtusifolium attenu pilocarpin induc injuri cultur astrocyt glial cell implic tempor lobe epilepsi human model astrocyt lost sever brain region acut seizur induc pilocarpin may suffer hyperplasia subsequ time point studi investig effect n methyl sr tran hydroxi l prolin nmp astrocyt expos cytotox concentr pilocarpin astrocyt incub pilocarpin half maxim inhibitori concentr ic mm h afterward treat nmp concentr rang gml h cell viabil assess dimethylthiazol yl diphenyltetrazolium bromid mtt assay cytoplasm reactiv oxygen speci ros mitochondri transmembran potenti analyz flow cytometri use dichlorofluorescein diacet dcfh da rhodamin rho respect express glial fibrillari acid protein gfap voltag depend anion channel vdac measur western blot pilocarpin signific decreas cell viabil mitochondri potenti increas ros concentr signific time compar control nmp concentr gml protect astrocyt pilocarpin induc injuri concentr depend manner concomit nmp reduc cytoplasm ros accumul group treat gml nmp respect nmp also protect mitochondria pilocarpin induc depolar effect associ improv pilocarpin induc gfap vdac overexpress import biomark astrocyt dysfunct conclus improv ros accumul vdac overexpress mitochondri depolar possibl mechan nmp protect action reactiv astrocyt

D010862;D029632

T123;T121;T002;T109

36,350,973

whole blood circular rna hsacirc serv potenti diagnost biomark human adenovirus pneumonia children sever pneumonia relat human adenovirus hadv high lethal rate children earli diagnosi treatment remain major challeng circular rnas circrna novel long noncod rnas play import role gene regul diseas pathogenesi investig role circrna hadv pneumonia analyz circrna profil healthi children children hadv pneumonia includ mild sever case identifi signific upregul circrna children hadv pneumonia vs healthi control signific upregul circrna children sever hadv pneumonia vs mild hadv pneumonia particular hsacirc differenti express group might thus use diagnost biomark hadv pneumonia sever hadv pneumonia identifi under mechan circrna hadv pneumonia analyz transcriptom children hadv pneumonia establish circrna mrna regulatori network enrich analysi differenti express target mrnas demonstr differenti express gene healthi control hadv pneumonia patient main involv rna splice differenti express gene children mild sever hadv pneumonia main involv regul lymphocyt activ receiv oper characterist roc curv analysi suggest hsacirc signific valu diagnosi hadv pneumonia sever hadv pneumonia taken togeth circrna express profil alter children hadv pneumonia result demonstr hsacirc potenti diagnost biomark hadv pneumonia

D000260;D011014

T005;T050;T047

36,350,972

protect role raltegravir experiment acut lung injuri vitro vivo disrupt pulmonari endotheli permeabl associ barrier integr increas sever acut respiratori distress syndrom ard studi investig potenti abil human immunodefici virus hiv integras inhibitor raltegravir protect acut lung injuri ali under mechan accord impact raltegravir treatment vitro lipopolysaccharid lps stimul human pulmonari microvascular endotheli cell hpmec model ali vivo lps induc two hit ali rat model examin rat model system raltegravir treatment allevi ali associ histopatholog chang reduc microvascular permeabl decreas evan blue dye extravas suppress express inflammatori protein includ hmgb tlr p nf b nlrp mpo promot upregul protect protein includ claudin cadherin aquaporin measur via western blot immunohistochem stain confirm abil raltegravir treatment revers lps induc pulmonari chang nlrp claudin aquaporin express furthermor vitro analys hpmec reaffirm abil raltegravir attenu lps induc declin cadherin claudin express simultan inhibit nlrp activ reduc express hmgb tlr nf kb thus decreas overal vascular permeabl overal find suggest raltegravir may repres viabl approach treat experiment ali function maintain pulmonari microvascular integr

D024243;D055371

T123;T116;T037

36,350,971

higher frequenc anal dysplasia infect human papillomavirus crohn diseas patient aim studi compar frequenc dysplasia human papillomavirus hpv infect anal canal patient crohn diseas cd control group assess whether correl use immunosuppress anal manifest cd patient cd control individu submit anal cytolog materi collect polymeras chain reaction pcr cytolog classifi normal atyp squamous cell undetermin signific ascus low grade squamous intraepitheli lesion lsil high grade hsil pcr consid posit negat accord virus presenc absenc total patient includ control group cd group without immunosuppress ascus lsil found control patient cd patient hpv identifi control group cd group cd patient hpv found without immunosuppress respect patient perian involv pcr posit statist differ dysplasia infect hpv group use immunosuppress influenc result anal manifest invers proport viral detect

D030361;D052685;D065309;D003424;D001005;D002583

T025;T191;T033;T005;T047

36,350,970

valid onlin predict tool cohort earli breast cancer brazil predict tool design estim benefit adjuv therapi overal surviv women earli breast cancer model use clinic histolog immunohistochem variabl studi aim evalu model perform brazilian popul assess discrimin calibr predict model estim overal surviv os five ten year follow cohort women earli breast cancer diagnos januari decemb total patient estrogen receptor er posit er negat tumor area receiv oper characterist roc curv auc discrimin ci five year ci ten year women er posit tumor auc ci five year ci ten year women er negat tumor predict surviv er posit tumor ci five year ci ten year observ surviv ci ci respect predict surviv er negat tumor ci five year ci ten year observ surviv ci ci respect conclus predict accur estim os women er posit tumor overestim os women er negat tumor

D001943

T191

36,350,969

allogen hematopoiet stem cell transplant children adolesc ethic problem face multidisciplinari team identifi ethic problem face multidisciplinari team allogen hematopoiet stem cell transplant children adolesc

D010166;D018380

T061

36,350,968

construct valid mobil applic health educ covid construct valid mobil applic health educ covid

D063731;D000086382

T047;T170;T067

36,350,967

assess women satisfact labor childbirth teach hospit assess satisfact puerper women regard labor childbirth

D010549;D017060

T033;T041;T080

36,350,966

spatiotempor pattern factor relat childhood tuberculosi identifi spatiotempor pattern childhood tuberculosi sociodemograph factor relat

D014376

T047

36,350,965

risk manag advers event matern hospit investig root caus advers event matern hospit risk manag

D006771;D012308

T058;T093

36,350,964

absente nurs nurs technician urgenc emerg unit associ absente nurs nurs technician work environ urgenc emerg care unit

D000041;D009741

T055;T097

36,350,963

effect mobil applic use knowledg human immunodefici virus among univers student evalu effect use mobil applic knowledg human immunodefici virus among univers student

D063731;D000163;D015658

T047;T170

36,350,962

factor associ presente outpati nurs profession analyz sociodemograph work health profil nurs profession work univers outpati clinic associ presente

D000069597;D010045

T101;T091

36,350,961

cross cultur adapt valid instrument measur nurs care depend cross cultur adapt valid iniciar instrument use brazil

D003431;D014177

T062;T170

36,350,960

central steril servic depart screen autom clean liposuct cannula evalu effect autom clean mm liposuct cannula use ultrason washer machin screen dirt use cannul microscop devic screen viabl strain staphylococcus aureus microbiolog analysi

D015187

T061

36,350,959

earli incision hernia liver transplant risk factor hernia repair result liver transplant complex valuabl therapi howev complic burden postop qualiti life incision hernia better elucid risk factor prophylact measur

D000069290;D016031;D006528;D008113;D006555

T061;T046;T191;T190

36,350,954

brazilian thorac associ recommend long term home oxygen therapi chronic respiratori diseas caus hypoxemia case long term home oxygen therapi ltot indic treatment option primarili improv patient qualiti life life expect home oxygen use year support ltot base two studi demonstr oxygen use improv surviv patient copd evid ltot benefici effect improv cognit function improv exercis capac reduc hospit ltot indic respiratori diseas caus hypoxemia basi criteria use copd increas use ltot probabl increas life expect higher preval chronic respiratori diseas well greater avail ltot health care system first brazilian thorac associ consensus statement ltot publish twenti two year later present updat version document nonsystemat review literatur conduct pulmonologist evalu scientif evid intern guidelin ltot various diseas caus hypoxemia specif situat ie exercis sleep air travel recommend produc view clinic practic contain sever chart inform indic ltot oxygen sourc accessori strategi improv effici effect recommend safe use ltot well ltot prescrib model

D011788;D029424

T078;T047

36,350,953

genet polymorph effect sever silicosi worker expos silica brazil silicosi pneumoconiosi character fibrosi lung parenchyma caus inhal silica particl genet factor might play role sever silicosi sought evalu influenc polymorph ace fas faslg nos ilrn fama tgfb tnf gene sever silicosi

D012822;D012829

T197;T047

36,350,952

lung cancer screen low dose ct integr pulmonari care public hospit southern brazil result first patient describ perform pulmonologist led lung cancer screen program use low dose ct ldct cohort outpati stabl respiratori diseas brazilian public health care system

D008175

T191

36,350,951

covid knowledg attitud practic among health care worker latin america evalu covid knowledg attitud practic among health care worker hcws practic latin american countri first surg covid pandem

D000086382

T047;T067

36,350,950

phytochemistri allelopathi anticanc potenti withania somnifera l dunal solanacea withania somnifera wild plant show great activ safeti sever human diseas current research explor plant chemic composit allelopath effect rumex dentatus recipi plant moreov anticanc activ also test four type human cancer cell line chemic analysi w somnifera show high percentag saponin tannin glycosid alkaloid flavonoid occur second order result allelopath experi reveal signific inhibit r dentatus plumul radicl length well relat dri weight addit signific reduct primari metabolit r dentatus like non reduc total sugar well solubl protein determin cytotox potenti w somnifera also prove four differ cancer line name human hepatocellular carcinoma cell line hepg human non small cell lung cancer cell line human breast cancer cell line mcf colon cancer cell line caco ic valu gml respect

D032341;D019657;D002289;D008175

T191;T002

36,350,949

foul resist investig seawe product solid unprotect undefend surfac aquat environ foul foul hand affect wide rang speci toler epibiosi sever other hand aggress keep epibiont bodi surfac antifoul antifoul defens built marin plant like seawe seagrass distinct surfac structur tight pack needl like peak antifoul cover may hinder settl bacteria abil cling chemic antifoul resist probabl biolog reaction epibiosi ecolog drawback especi organ capabl perform photosynthesi goal studi see effect natur compound deriv littor seawe prevent foul brown mussel import foul organ evalu laboratori bioassay fifti one popul crude organ extract includ fort two macroalga speci antifoul activ exhibit distinct phylogenet pattern red macroalga largest share activ speci subsequ brown macroalga antifoul action green seawe never signific seven speci show level induc antifoul defens find appear back previous find secondari metabolit synthesi seawe indic hunt novel antifoul research concentr effort tropic red macroalga

D012624;D049872

T204

36,350,948

occurr densiti mollusc speci differ area basrah provinc southern iraq first record invas golden mussel limnoperna fortunei dunker studi conduct compar distribut composit mollusc communiti ecosystem site southern iraq name site euphrat river al madinah citi site shatt al arab al sharsh area site garmat ali river al mashib area site al seba area sampl collect studi site period januari august speci class gastropoda speci class bivalv speci predomin studi month speci melenodi nodosa bellamya bengalensi melanopsi turbculata gastropoda two speci bivalv corbicula fluminali limnoperna fortunei dunker last speci l fortunei record current studi first time freshwat iraq total biodivers valu mollusc euphrat river al madinah area site al sharsh area site al mashib area site al seba area site respect note highest season densiti speci current studi record winter season reach individu four site respect

D049879;D049851

T204

36,350,947

associ tinnitus self report system arteri hypertens retrospect studi describ data hear loss system arteri hypertens tinnitus individu verifi associ self report system arteri hypertens tinnitus well correl variabl present sampl hear loss tinnitus age tinnitus age system arteri hypertens

D014012;D034381;D006973;D003638

T033;T184;T047;T037

36,350,946

major advers cardiovascular event caus mortal emerg general surgeri among kidney failur patient emerg general surgeri eg associ increas mortal kidney failur contribut risk compar outcom patient kidney failur general popul lack

D051437;D002318

T047

36,350,945

associ biopsychosoci factor self report covid clinic complic brazilian citi studi aim analyz exist associ biopsychosoci profil peopl affect number self report clinic complic covid brazilian citi

D000086382

T047;T067

36,350,944

evalu antibacteri properti shear bond strength orthodont composit contain silver nanoparticl titanium dioxid nanoparticl fluorid vitro studi studi aim determin antibacteri properti composit contain silver nanoparticl ag nps titanium dioxid nanoparticl tio nps fluorid releas composit streptococcus mutan lactobacillus acidophilus evalu effect shear bond strength sbs nanoparticl modifi composit

D053768;D016910

T074;T073

36,350,943

efficaci product bleach whiten orthodont bracket mani patient wear orthodont applianc request alter shade teeth orthodont treatment

D016910;D058205;D014073

T061;T074;T167

36,350,942

extern apic root resorpt orthodont treatment analysi differ chronolog period extern apic root resorpt earr character definit loss tooth root structur higher incid later central maxillari incisor

D012391

T047

36,350,941

biochem physiolog growth evalu differ chickpea genotyp vari salin regim biochem physiolog paramet growth yield field crop especi salt sensit crop like chickpea affect advers salin arid semi arid region investig effect differ salin level growth biochem physiolog paramet chickpea genotyp pot experi follow crd two factor factori design conduct glasshous institut biotechnolog genet engin univers agricultur peshawar pakistan ten kg soil fill pot salin level maintain mm nacl mm nacl mm nacl mm appli nacl genotyp chickpea kk bhakkar bittl punjab cm use crop matur growth paramet physiolog biochem ionic paramet measur use standard analysi procedur salin reduc growth yield genotyp rate decreas differ among genotyp test result decreas k concentr kna ratio transpir rate stomat conduct n p observ genotyp increas salin increas salin level increas prolin content crude protein ho lipid peroxid carbohydr na concentr highest level salin mm nacl exhibit highest salin stress paramet genotyp kk bhakkar show lower rate relat decreas yield kna ratio k concentr respect lowest relat increas na accumul mm salin compar control genotyp kk bhakkar prove better mm salin find suggest critic level salin must kept mind salt toler genotyp cultiv salt affect soil

D054712;D029863

T168;T034;T002

36,350,940

studi integu cover back stinger freshwat stingray potamotrygon rex chondricthy potamotrygonida object studi describ histolog histochemistri integu cover back stinger freshwat stingray potamotrygon rex endem middl upper tocantin river speci dark back yellowish circular spot extend tail one two sting locat median portion tail histolog studi observ epithelia back stinger compos non keratin stratifi pavement epitheli tissu organ three layer basal intermedi superfici differ tissu relat cell type compos back organ epitheli cell mucus cell granulocyt cell chromatophor mucus cell distribut differ layer along anim back influenc thick tissu tissu cover stinger compos epitheli cell chromatophor special cell protein synthesi histochemistri stinger epitheli cell stain bromophenol blue especi intermedi layer call special cell back epitheli cell stain bromophenol blue alcian blue pas mucous cell pas tissu presenc protein reserv detect area call stain strong bromophenol blue result show stinger present activ direct product protein back organ produc differ compon constitut cuticl cover anim bodi

D012860;D001733

T037;T013

36,350,939

socioeconom aspect profil fish accord fisher commerci edibl fish municip barcelo middl negro river amazona brazil fish play promin role socioeconom scope negro river basin consid one main extract activ region object studi describ socioeconom aspect commerci fisher edibl fish work municip barcelo middl negro river region well highlight scenario fish activ point view fisher inform collect januari decemb municip barcelo state amazona via semi structur questionnair interviewe male age year mean age year low level educ incomplet elementari educ illiter fish tackl use fishermen gillnet especi urban fishermen among fish site main one demeni river commerci fish edibl fish barcelo focus characiform perciform siluriform fish main difficulti face activ relat season level river local tributari well lack buyer low sell price fish addit conflict use fish resourc commerci fish edibl fish activ great socioeconom import riversid famili middl river negro basin need greater attent public author therefor expect inform contain studi help decis make process manag local fisheri resourc contribut resumpt growth sustain commerci edibl fish fisheri

D045483;D003247

T078;T070;T069;T081;T064

36,350,938

resist sorghum hybrid sorghum aphid aphid melanaphi sorghi theobald hemiptera aphidida infest sorghum crop econom import pest caus sever damag sorghum crop brazil sinc speci observ main end veget stage begin reproduct stage plant high reproduct rate sorghum rais concern pest therefor present studi aim estim life expect fertil tabl melanaphi sorghi fed hybrid grain sorghum order know resist characterist materi understand plant resist help manag insect studi carri laboratori c rh relat humid fifti insect kept hybrid insect consid one repetit accord biolog paramet fertil life tabl hybrid brs dkb less suitabl sugarcan aphid multipl thus hybrid could use manag pest sinc popul growth speed one worst problem implement crop system genotyp ag msk xgn favor develop pest chosen within crop system manag strategi consid

D001042;D045868

T002;T204

36,350,936

afrosymetr method quantifi saponin chenopodium quinoa willd colombia quinoa chenopodium quinoa willd pseudocer addit present good nutrit characterist grain secondari metabolit episperm seed within saponin saponin character emulsifi foam generat bitter tast metabolit complet studi quinoa materi colombia reason object research quantifi content saponin present quinoa materi depart boyac use three afrosimetr method complet random design crd implement factori arrang afrosimetr method x quinoa materi quantif saponin determin amarilla de marangan genotyp one present highest content evalu method standard afrosimetr method effici final conglomer analysi allow discrimin materi sweet quinoa tunkahuan blanca de jeric saponin content lower bitter quinoa negra de la colorada dorada amarilla de marangan content higher biochem character germplasm allow select genotyp suitabl consumpt industri given potenti use saponin current

D027465;D012503

T168;T002;T109

36,350,935

express analysi phosphat induc gene contrast maiz genotyp phosphorus use effici phosphorus essenti nutrient plant growth develop abil plant acquir phosphat pi rhizospher soil critic brazilian cerrado character acid soil induct pi transport one earliest molecular respons pi defici plant studi character transcript regul six zmpt zmpt high affin pi transport gene four pi effici four pi ineffici maiz zea may genotyp express analysi indic pi starvat induc transcript zmpt gene test abund transcript invers relat pi concentr nutrient solut observ earli five day follow pi depriv pi starv plant replenish pi four five day result zmpt suppress indic pi role gene express tissu specif express analysi reveal abund zmpt transcript root shoot six maiz pi transport primarili detect upper middl root portion bare express root tip express profil six zmpts phosphat transport among pi effici pi ineffici genotyp show absenc signific differ express pattern zmpts among pi effici pi ineffici genotyp result suggest pi acquisit effici complex trait determin quantit loci maiz

D003313;D010710

T168;T197;T002

36,350,927

ocular manifest monkeypox case report monkeypox diseas viral zoonosi symptom similar seen past smallpox variola although clinic less sever follow erad smallpox subsequ cessat smallpox vaccin monkeypox emerg import orthopoxvirus public health standpoint monkeypox virus occur primarili central western africa often tropic forest increas manifest urban area anim host includ various rodent nonhuman primat report case patient monkeypox diseas develop ocular complaint eye discomfort conjunct detect conjunctiv lesion biomicroscopi fluorescein test ophthalmolog manifest still poor known

D045908;D012899

T047

36,350,926

microbi effect prebiot probiot synbiot caesarean section exposur antibiot first week life systemat review disrupt develop microbiota caesarean birth earli exposur antibiot may impact long term health outcom potenti prevent nutrit supplement systemat review aim summaris evid regard effect prebiot probiot synbiot intestin microbiota composit term infant born caesarean section expos antibiot first week life

D058616;D019936

T168;T007

36,350,925

impact covid pandem earli career dementia research global onlin survey world health organ recogn dementia public health prioriti highlight research action respond consequ earli career dementia research ecdr repres key drive forc due covid pandem howev biomed psychosoci dementia research strain worldwid aim studi understand impact pandem ecdr

D000086382;D000544;D061108

T047;T170;T067;T048

36,350,924

health inform covid vaccin belief attitud among japanes univers student coronavirus diseas covid vaccin adolesc young adult import infect control factor influenc vaccin behavior age group includ sourc inform vaccin social norm howev studi factor influenc vaccin behavior among japanes univers student studi aim assess belief attitud sourc inform covid vaccin among univers student japan cross section onlin questionnair survey conduct among student teikyo univers japan septemb survey design collect demograph inform vaccin status attitud belief anxieti vaccin sourc inform whether particip watch educ movi factor associ belief attitud analyz use logist linear regress total valid questionnair retriev posit vaccin behavior group includ student common sourc inform covid vaccin tvradio common social network servic sns covid inform twitter approxim student believ efficaci vaccin posit attitud associ femal sex watch educ movi univers concern vaccin posit associ inform acquaint instagram negat associ inform twitter watch educ movi major student posit belief attitud toward covid vaccin social media educ movi produc univers larg influenc attitud toward vaccin behavior contrari student anxious vaccin promot educ movi social media univers effect way encourag vaccin among young peopl

D000086382;D014612

T129;T121;T116;T067;T047

36,350,923

integr gene analys de novo variant trio autism development disord genet studi consid autism spectrum disord asd development disord dd separ despit overwhelm comorbid share genet etiolog analyz de novo variant dnvs asd spark dd trio independ also combin broader neurodevelopment disord ndds use three model identifi ndd candid gene fals discoveri rate fdr support model includ reach bonferroni exom wide signific p e model gene group five function network associ differ brain development lineag base singl cell nuclei transcriptom data find evid asd specif gene contrast gene signific enrich dd gene show mutat bias includ enrich missens n truncat n dnvs also find gene evid male femal bias enrich includ x chromosom gene signific femal burden ddxx mecp wdr hdac larg scale integr analysi identifi candid function subset ndd gene

D001321;D000067877

T048

36,350,921

host circadian behavior exert weak select pressur gut microbiom stabl condit critic recoveri antibiot treatment circadian rhythm host dictat approxim h transform environ experienc gut microbiom consequ cyclic environ intestin microbiota bare understood like medic ramif daili rhythmic gut act select pressur shape microbi communiti moreov given sever bacteri speci report exhibit circadian rhythm test whether rhythmic environ select pressur favor clock harbor bacteria anticip prepar consist daili chang environ observ daili rhythmic mous gut environ stabil influenc facilit microbiot recoveri antibiot perturb composit microbiom recov pretreat condit expos consist daili rhythmic wherea host whose feed activ pattern tempor disrupt microbiot recoveri incomplet allow potenti unhealthi opportunist exploit tempor disarray unexpect found absenc antibiot perturb gut microbiom stabl rhythmic versus disrupt feed activ pattern comparison result studi reveal intrigu correl stabl microbiom may resili one perturb alon eg disrupt daili time host behavior feed multipl perturb combin howev perturb stabl microbiom regular daili pattern host behaviorfeed appear essenti microbiom recov origin steadi state given inconsist daili rhythm modern human life eg shiftwork social jet lag irregular eat habit result emphas import consist daili rhythmic optim health direct host also indirect preserv host microbiom face perturb

D000069196;D064307

T032;T007;T028;T001

36,350,920

reason mental state uncertainti theori mind tom abil infer mental state other integr facilit healthi social interact peopl reason mental state other even limit sometim inconsist inform howev littl known peopl make infer mental state other uncertainti featur inform import aid mental state reason current studi conduct three uniqu experi alter particip uncertainti engag tom test experi simultan manipul amount consist inform avail social stimuli present particip experi aim deciph featur social stimuli conduc mental state reason experi manipul amount inform avail particip experi manipul consist inform avail particip use frequentist bayesian statist result confirm manipul amount consist inform alter tom perform exploratori analysi compar effect amount consist inform suggest effect consist inform seem stronger amount inform taken togeth three experi suggest amount consist inform import featur social stimuli consist inform avail salient infer mental state other find discuss relat inform theori import implic creat enrich social stimuli may enhanc mental state reason individu social deficit

D056345

T078

36,350,919

privaci assur work studi truth healthcar histori data collect patient often provid untruth inform health avoid embarrass evad treatment prevent financi loss privaci disclosur eg hipaa intend dissuad privaci concern may actual increas patient lie use new mous track base technolog detect lie mous movement distanc time respons patient answer adjust onlin control studi potenti patient random assign one six treatment treatment differ notic patient receiv health inform request includ notic privaci benefit truth disclosur risk inaccur disclosur increas time distanc devic mous movement greater adjust answer indic less truth mous track reveal signific overal effect p lt treatment time reach final choic control took least time indic greater truth privaci risk group took longest indic least truth privaci risk benefit disclosur statement led greater lie differ moder gender mous track result larg confirm answer adjust lie detect method overal treatment effect p lt gender differ p lt truth privaci notic led decreas patient honesti privaci notic perhap administ well person health disclosur request minim patient untruth mous track answer adjust appear health care lie detect method enhanc optim diagnosi treatment

D018907;D003219

T033;T078;T089;T170

36,350,899

experi particip clinic trial novel radioact treatment advanc prostat cancer nest qualit longitudin studi qualit studi nest within clinic trial provid insight treatment experi evolv time improv support care requir purpos qualit studi describ live experi men advanc prostat cancer particip therap trial randomis trial lu psma compar cabazitaxel chemotherapi

D011471

T191

36,350,898

evalu use semi structur crowdsourc data quantifi inequit access urban biodivers case studi ebird credibl estim social ecolog relationship requir data broad coverag fine geograph resolut typic avail standard ecolog survey open unstructur data crowdsourc platform offer opportun collect larg quantiti user submit ecolog data howev repres area sampl data portal well known investig data avail ebird one largest popular crowdsourc scienc platform correl race incom census tract two citi boston phoenix az find checklist submiss vari great across census tract similar pattern within metropolitan region particular census tract high incom high proport white resid like repres data citi indic select bias ebird coverag result illustr non repres ebird data also rais deeper question valid statist infer regard dispar drawn dataset discuss challeng illustr sampl select problem unstructur semi structur crowdsourc data lead spurious conclus regard relationship race incom access urban bird biodivers crowdsourc data indispens complementari tradit approach collect ecolog data conclud unstructur semi structur data may well suit line inquiri particular requir consist data coverag thus handl appropri care

D063045

T062;T170

36,350,897

structur base virtual screen molecular dynam potenti inhibitor target sodium bile acid co transport carcinogen liver fluke clonorchi sinensi clonorchi sinensi requir bile acid transport fluke inhabit bile juic fill biliari duct provid extrem environ clonorchi sinensi sodium bile acid co transport cssbat indispens fluke surviv final host circul taurochol prevent bile toxic fluke henc recogn use drug target

D003004;D005210;D003003;D027981

T123;T047;T116;T204

36,350,896

protocol isistaquit implement phase support indigen smoker assist quit project aborigin andor torr strait island women smoke pregnanc compar general popul counterpart evid base quit smoke advic receiv health care profession hcps increas smoke cessat rate howev hcps lack cultur appropri smoke cessat train major barrier provis smoke cessat care popul

D016540;D006303

T055;T058