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36,350,494
evalu environment risk assess heavi metal soil releas e wast manag activ lahor pakistan develop region electron wast either get recycl use crude primit techniqu recycl center dump dump ground result leach heavi metal ambient environ object studi determin concentr heavi metal cu pb zn cd mn fe surfac soil recycl center dump site lahor pakistan quantifi compar environment risk mean concentr mgkg cu pb zn cd respect surfac soil recycl center mean concentr cu mgkg dump site permiss limit world health organ result geo accumul index igeo contamin factor cf reveal surfac soil high contamin cu pb cd cd content caus high potenti ecolog risk er nearbi biolog communiti noncarcinogen risk expect pb children live near recycl center wherea risk observ adult live either near recycl center dump site high probabl carcinogen health risk children adult cu henc result suggest e wast recycl dump activ signific sourc heavi metal surround environ children adult strong recommend take action sustain manag e wast
D059029;D012989;D019216
T068;T196;T131
36,350,466
integr approach impact assess tank water groundwat qualiti coimbator region south india implic anthropogen activ groundwat coimbator region much essenti irrig human be day day life activ research focus impact anthropogen activ surfac water qualiti four tank coimbator citi influenc disturb groundwat qualiti well water qualiti degrad result encroach anthropogen activ dispos municip garbag wast enterpris nearbi tank degrad qualiti water tank pollut concentr surfac water togeth leech organ may percol via pore space soil particl interact groundwat qualiti groundwat impact result interact result water qualiti metric surfac groundwat assess studi spatial interpol perform use arcgi map spatial distribut water qualiti produc use arcgi spatial interpol water qualiti map help research understand qualiti surfac groundwat chang time visual modflow mtd use simul groundwat flow modflow program use simul direct groundwat flow base groundwat level rainfal data output mtd allow accur calcul pollut movement amount direct studi chlorid use pollut transport paramet semi structur interview done studi region find avail drink water wast dispos diseas spread among resid live close tank
D060587;D004785;D014874
T081;T131;T070;T082
36,350,456
spatiotempor dynam ecolog secur typic conserv region southern china base catastroph theori gis ecolog secur assess effect reflect ecolog status region reveal level sustain develop paper ecolog secur orient evalu system construct ecolog secur level dongjiangyuan region evalu base catastroph theori gis result follow shown land use cover map forestland area decreas artifici surfac area increas ecolog secur index dongjiangyuan region show low trend artifici surfac area surround area quit low valu ecolog secur index improv due increas ecolog servic capac increas veget cover promot improv ecolog servic capac rapid urban process dongjiangyuan region result lower ecolog sensit index valu notabl ecolog sensit index studi area slight decreas trend spatial autocorrel show proport hot cold spot decreas respect studi provid scientif basi decis make guidanc ecolog manag dongjiangyuan region futur
D004463;D003247
T078;T090;T069;T081;T064
36,350,436
fast sub hz potentiostaticgalvanostat bio imped measur use chaotic oscil measur bio imped spectra ultra low frequenc sub hz known requir consider long time classic frequenc sweep method narrow band period excit signal work imped measur techniqu base use wide band chaotic signal propos experiment valid frequenc rang formula see text techniqu test potentiostat galvanostat mode first use commerci compon use enhanc howland current pump design fabric nm cmos technolog accuraci propos techniqu assess fruit sampl compar measur conduct use research grade biolog vsp electro chemic station
D017097
T039;T070
36,350,434
nattokinas enhanc prevent effect escherichia coli nissl dextran sulfat sodium induc coliti mice nattokinas excel anti thrombot anti inflammatori anti tumor anti hypertens properti use develop sever healthcar product mani countri probiot escherichia coli nissl ecn anti inflammatori effect common use treat inflammatori bowel diseas determin whether nattokinas could enhanc therapeut efficaci ecn coliti recombin e coli nissl strain ecnnatto nattokinas express abil success construct protect effect engin strain mice experiment chronic coliti investig although ecn ecnnatto strain substanti allevi clinic symptom patholog abnorm coliti mice regul gut flora maintain intestin barrier function ecnnatto strain found perform better control strain base increas colon length downregul pro inflammatori cytokin il tnf nattokinas express ecn attenu dss induc epitheli damag restor mucos integr upregul level tight junction protein includ zo occludin express level lgr marker intestin stem cell also increas moreov constitut express nattokinas ecn revers gut microbi rich divers coliti mice base find nattokinas could strengthen capac ecn treat intestin inflamm
D003092;D004927;D019936
T047;T007
36,350,431
mini review environment metabol factor affect aminoglycosid efficaci follow discoveri streptomycin streptomyc griseus selman waksman colleagu aminoglycosid first use treat tuberculosi numer deriv sinc use combat wide varieti bacteri infect bactericid antibiot use first line treatment sever decad larg replac lactam fluoroquinolon although widespread emerg antibiot resist led renew interest aminoglycosid primari site action aminoglycosid ribosom subunit disrupt protein translat contribut widespread cellular damag number secondari effect includ rapid uptak aminoglycosid via elev proton motiv forc pmf membran damag breakdown oxid stress hyperpolaris membran sever factor associ aminoglycosid entri shown impact upon bacteri kill recent work reveal complex relationship metabol state efficaci differ aminoglycosid henc imper consid environment condit bacteri physiolog impact upon aminoglycosid entri potenc mini review seek discuss recent advanc area might affect futur use aminoglycosid
D000617;D013305
T121;T007;T109
36,350,426
inhibitor induc wavetrain spiral wave extend fitzhugh nagumo model nerv cell dynam well known fitzhugh nagumo model one simplifi form four variabl hodgkin huxley model reflect signific phenomena nerv cell action potenti howev model captur irregular action potenti suffici larg period one paramet famili solut motiv propos modifi fitzhugh nagumo reaction diffus system chang recoveri kinet first investig paramet regim know exist wavetrain second conceiv occurr eckhaus bifurc solut divid solut region two part essenti spectra differ grid point explor occurr bifurc wave find wavetrain suffici larg period cross stabil boundari characterist phenomenon absent standard fitzhugh nagumo model final observ reason agreement direct pde simul solut travel wave ode furthermor model exhibit spiral wave monoton non monoton case agre wave observ cellular activ
D008954;D055641
T081;T075
36,350,414
lower socioeconom status associ increas co morbid burden independ associ time surgeri length hospitalis readmiss rate hip fractur patient studi examin relationship socioeconom status comorbid clinic outcom hip fractur patient lower socioeconom status associ poorer comorbid also independ impact surgic access outcom consid doubl setback manag hip fractur
D010359;D006620
T058;T037
36,350,413
first high qualiti chromosom level genom assembl phyllanthacea phyllanthus cochinchinensi provid insight flavonoid biosynthesi report genom assembl p cochinchinensi first high qualiti chromosom level genom phyllanthacea rich medicin plant phyllanthus cochinchinensi member phyllanthacea one famous medicin plant south china report de novo chromosom level genom assembl p cochinchinensi use combin nanopor illumina sequenc technolog total assembl genom consist mb genom sequenc contig n mb repres estim genom size appli hi c data pseudochromosom p cochinchinensi construct cover assembl sequenc genom annot repetit sequenc protein code gene whole genom duplic p cochinchinensi like share ricinus communi well viti vinifera homolog gene within flavonoid pathway p cochinchinensi identifi copi number express level relat gene reveal potenti critic gene involv flavonoid biosynthesi studi provid first whole genom sequenc phyllanthacea confirm evolutionari status phyllanthus genom level provid foundat acceler function genom research speci phyllanthus
D029803;D000076622
T002
36,350,410
glandular trichom specif menthol biosynthesi pathway gene promot mentha piperita sever cis element includ myb bind motif togeth confer glandular trichom specif reveal heterolog express analysi menthol biosynthesi pathway gene promot glandular trichom gts result divis epiderm cell produc divers metabolit speci mint famili import essenti oil contain mani high valu terpenoid biosynthes store gts henc gts constitut attract target metabol engin gt specif promot import investig upstream region mentha piperita menthol biosynthet pathway gene limonen synthas p limonen hydroxylas tran isopiperitenol dehydrogenas isopiperitenon reductas pulegon reductas menthon reductas menthol dehydrogenas branch pathway gene menthofuran synthas isol character fragment fuse glucuronidas gus report gene pbi binari vector abl drive high level gene express transgen tobacco trichom strong signal gts except isopiperitenon reductas gt enrich tissu transform plant analys gus enzym activ rna express correl gus stain character cis element respons gt specif express seri delet construct mppls mppmfs clone analys stabl transgen tobacco line specif trichom express locat bp sequenc limonen synthas bp menthofuran synthas promot contain specif myb bind motif addit uniqu motif describ development regul without defin pattern pathway promot also recruit specif differ myb factor indic analysi
D064201;D036142
T023;T002
36,350,399
develop one step multiplex rt pcr assay rapid simultan detect five rna virus acidovorax citrulli major cucurbitac crop china cucurbitac fruit veget import crop viral bacteri diseas caus substanti econom loss cucurbit crop global rapid detect pathogen improv diseas control one step multiplex revers transcript polymeras chain reaction mrt pcr system creat method allow concurr detect tobacco mosaic virus tmv zucchini yellow mosaic virus zymv watermelon mosaic virus wmv cucumb green mottl mosaic virus cgmmv cucumb mosaic virus cmv acidovorax citrulli five pair specif primer creat accord conserv region around coat protein cp gene virus one pair base citrulli intern transcrib spacer limit fals negat one pair primer creat base transcript elong factor ef major cucurbitac crop speci put mrt pcr reaction system primer concentr anneal temperatur extens time amplif cycl optim anticip fragment bp tmv bp zymv bp wmv bp cgmmv bp cmv bp citrulli bp ef amplifi multiplex rt pcr system origin establish via dna sequenc method success use examin field collect seed sampl cucurbitac crop china result demonstr one step mrt pcr techniqu quick effici sensit assay concurr detect six pathogen cucurbit provid method monitor prevent diseas
D017800;D003586
T005;T047
36,350,388
aptasensor detect infecti pathogen design strategi point care test epidem infecti diseas caus contagi pathogen life threaten hazard entir human popul worldwid time accur diagnosi critic link fight infecti diseas aptam base biosensor call aptasensor employ nucleic acid aptam bio receptor recognit target pathogen interest review focus design strategi well state art technolog aptasensor base diagnost infecti pathogen main bacteria virus cover util three major signal transduc employ aptam recognit moieti construct versatil biosens platform most micro nanomateri base innov report mechan signal enhanc approach advanc point care test poct infecti diseas diagnost also discuss highlight repres readi use devic address urgent need current preval coronavirus diseas covid press issu aptam base technolog futur perspect aptasensor provid implement aptasensor base diagnost practic applic
D052157;D000086382;D015374;D003141
T075;T067;T059;T114;T047
36,350,325
integrin regul margin zone b cell differenti pik signal margin zone mz b cell repres innat like b cell mediat fast immun respons adhes mz b cell margin sinus spleen govern integrin address question whether integrin addit function analyz itgbflflcdcr mice integrin gene delet matur b cell find integrin defici mice defect differenti mz b cell plasma cell show integrin defici transit b cell repres precursor mz b cell enhanc b cell receptor bcr signal alter pik raserk pathway enhanc interact integrin link kinas ilk adaptor protein grb moreov mz b cell defect integrin defici mice could least part restor pharmacolog inhibit pik pathway thus integrin unexpect function differenti function mz b cell
D019012;D019869
T129;T126;T116
36,350,316
man cardiac tamponad ruptur coronari arteri aneurysm case report describ diagnosi cardiac tamponad secondari ruptur coronari arteri aneurysm man present acut chest pain dyspnea
D002305;D003323;D017542
T047
36,350,314
activ sgc crosstalk mous vascular nich promot vascular integr mitig acut lung injuri disrupt endotheli cell ec pericyt interact result vascular leakag acut lung injuri ali howev molecular signal mediat ec pericyt crosstalk system investig whether target crosstalk could adopt combat ali remain elus use compar genom wide ec pericyt crosstalk analysi healthi lps challeng lung discov crosstalk endotheli nitric oxid pericyt solubl guanyl cyclas sgc impair ali inde stimul sgc pathway promot vascular integr reduc lung edema inflamm induc lung injuri pericyt specif sgc knockout abolish protect effect mechanist sgc activ suppress cytoskeleton rearrang pericyt inhibit vasp depend f actin format mrtfasrf depend de novo synthesi gene associ cytoskeleton rearrang therebi lead stabil ec pericyt interact collect data demonstr impair sgc crosstalk vascular nich result elev vascular permeabl pharmacolog activ crosstalk repres promis translat therapi ali
D020286;D055371
T025;T037
36,350,310
regul cdc protein turnov modul filament growth mapk pathway rho gtpase central regul cell polar signal rho gtpase direct function certain set remain unclear show protein level yeast rho gtpase cdcp regul impact subset biolog function specif activ conform cdcp ubiquitin nedd ubiquitin ligas rspp hsphsp chaperon turn proteasom gtp lock ql turnov defect td version cdcpqltd hyperactiv mapk pathway regul filament growth fmapk cdcpqltd influenc activ mate pathway share compon fmapk pathway fmapk pathway adaptor bemp stabil cdcp level result elev fmapk pathway signal result identifi cdcp turnov regul critic regul mapk pathway control rho gtpase level stabil turnov may general featur signal pathway regul result execut specif development program
D020846;D029701
T126;T116
36,350,294
converg two global regul coordin express essenti virul determin mycobacterium tuberculosi cyclic amp camp known function global regul mycobacterium tuberculosi gene express sequenc base transcriptom profil identifi mycobacteri regulon control camp receptor protein crp studi identifi new subset crp associ gene includ virul determin also control major regul phop result suggest phop dna bind transcript factor impact express gene phosphoryl phop promot crp recruit target promot uncov distinct regulatori mechan show activ gene requir direct recruit phop crp target promot fundament biolog insight deriv inhibit crp bind regulatori region phop delet strain owe crp phop protein protein interact base result model propos suggest crp phop function co activ essenti pathogen determin taken togeth result uncov novel mode regul complex two interact virul factor impact express virul determin result signific implic tb pathogenesi
D009169
T007
36,350,291
correl right ventricular echocardiographi measur function capac patient pulmonari arteri hypertens accelerometri emerg option real time evalu function capac patient pulmonari arteri hypertens pah prospect pilot studi assess relationship function capac accelerometri right ventricular measur echocardiographi high risk cohort
D018497;D000081029;D006976
T047;T046
36,350,290
coronari arteri stenosi caus primari malign pericardi mesothelioma year old man report describ year old man diabet mellitus develop coronari arteri stenosi infiltr primari malign pericardi mesothelioma three month referr treat hospit elev liver function valu cardiac enzym led echocardiographi reveal motion abnorm anterior wall heart patient diagnos congest heart failur admit hospit chest comput tomographi show tumor left atrial appendag compress origin left anterior descend arteri refer treat hospit surgeri minim invas direct coronari arteri bypass graft perform mass resect infiltr natur potenti medic complic histolog examin biopsi specimen confirm primari malign pericardi mesothelioma bypass procedur resolv coronari arteri stenosi caus tumor although optim treatment primari malign pericardi mesothelioma controversi minim invas method minim invas direct coronari arteri bypass graft may use success
D023921;D006338;D008654
T047;T191
36,350,289
transgen forc sensor softwar measur forc transmiss across mammalian nuclear envelop vivo nuclear mechanotransduct grow field excit implic regul gene express cellular function mechan signal may transduc nuclear interior biochem physic connect cell surfac chromatin defin mechan stress upon nucleus physiolog set generat transgen mous strain harbour fret base tension sensor control construct outer inner aspect nuclear envelop knock publish esprin g sensor measur tension across linc complex generat new sensor link inner nuclear membran chromatin mitig challeng inher fluoresc lifetim analysi vivo develop softwar flimvivo mark improv fit fluoresc decay curv mous embryo sensor respond cytoskelet relax stretch appli micro aspir report organ specif differ spatiotempor tension gradient along proximodist axi limb bud rais possibl mechan mechan coregul pattern format mous strain softwar potenti valuabl tool test refin mechanotransduct hypothes vivo
D009685;D040542
T026;T044
36,350,286
cell primari cilium autonom ca compart paracrin gaba signal primari cilium organell present adult mammalian cell consid antenna sens local microenviron use intact mous pancreat islet langerhan investig signal properti primari cilium insulin secret cell find gabab receptor strong enrich base cilium mobil distal locat upon agonist bind use cilia target ca indic find activ gabab receptor induc select ca influx primari cilia mechan requir voltag depend ca channel activ islet cell util cytosol ca increas main trigger insulin secret yet find increas cytosol ca fail propag cilium isol larg due enhanc ca extrus cilium work reveal local gaba action primari cilia involv ca influx depend restrict ca diffus cilium cytosol
D002923;D007515
T026;T023
36,350,279
acut abdomen post covid multisystem inflammatori syndrom children case report data coronavirus diseas covid gather becom evid children expos covid develop rare complic multisystem inflammatori syndrom children mis c report case year old boy brought emerg room suspect acut abdomen diagnos mis c
D000086382;D000006
T184;T047;T067
36,350,259
migrain word fiction book review na
D008881
T047
36,350,250
effici electrotransform bacillus thuringiensi gene manipul express genet manipul bacillus spp b thuringiensi b cereus labori time consum due challeng transform plasmid dna construct larger shuttl plasmid pmad common use markerless gene replac particular difficult transform bacillus spp present robust protocol work effici transform small larg plasmid construct b thuringiensi protocol involv prepar effici electrocompet bacillus cell cultiv cell presenc cell wall weaken agent follow wash cell optim solut protocol highlight import use unmethyl plasmid dna effici transform b thuringiensi author current protocol publish wiley period llc basic protocol prepar electrocompet b thuringiensi basic protocol transform b thuringiensi
D001413;D001407
T007
36,350,247
map maiz mutant use bulk segreg analysi next generat sequenc forward genet use identifi genet basi phenotyp approach involv identifi mutant organ exhibit phenotyp interest map causat locus gene bulk segreg analysi bsa quick effect approach map mutant use pool mutant wild type plant segreg popul identifi linkag mutant phenotyp approach success use plant tradit linkag map approach outdat time intens difficult high evolv develop reduct cost high throughput sequenc new approach combin bsa becom extrem effect multipl plant speci includ zea may maiz approach incred power care experiment design bioinformat map techniqu interpret result import obtain desir result effect time manner poor design map popul limit bioinformat experi inadequ understand sequenc data limit approach research describ straightforward protocol map mutat respons phenotyp interest maiz use high throughput sequenc bsa specif discuss relev aspect develop mutant map popul follow detail protocol dna prepar analysi short read sequenc map identifi candid causat mutat respons mutant phenotyp interest provid command line perl script complet bioinformat analysi mutant sequenc data protocol lay design bsa bioinformat approach interpret sequenc data method adapt forward genet experi provid step step approach identifi genet basi maiz mutant phenotyp author current protocol publish wiley period llc basic protocol bulk segreg analysi high throughput sequenc map maiz mutant
D003313;D059014
T063;T168;T059;T002
36,350,242
fresh transfer averag qualiti slow grow day embryo versus frozen transfer poor respond clinic manag dilemma common conundrum face clinician whether go fresh transfer cultur embryo futur frozen transfer case slow grow embryo case report describ success pregnanc fresh transfer singl day cell grade b embryo patient poor ovarian reserv although research need context fresh transfer consid treatment option patient optim endometrium well control progesteron level slow grow embryo
D004624;D050498
T061;T033
36,350,241
stage endometriosi affect oocyt qualiti embryo develop fertil rate investig effect endometriosi differ stage intracytoplasm sperm inject icsi outcom among infertil women without previous histori ovarian surgeri
D004715;D007247
T033;T047;T191;T046
36,350,237
relationship health literaci mental health attitud belief mental health first aid program show promis reduc stigma increas help seek howev success mental health intervent like affect health literaci yet health literaci understudi mental health literatur rare consid mental health intervent
D008603;D057220
T041
36,350,236
relationship health literaci self efficaci self care behavior older adult hypertens north iran hypertens main risk factor cardiovascular diseas low level health literaci common peopl hypertens evid suggest hypertens prevent control modifi lifestyl improv self care behavior
D057220;D006973
T047;T041
36,350,235
hous food insecur health literaci maladapt cope behavior stressor relat social determin health sdh hous food insecur implic chronic diseas risk maladapt strategi cope stressor may exacerb risk
D006798;D057220
T073;T041
36,350,222
concurr anthropogen air pollut enhanc recruit specialist parasitoid air pollut nitrogen oxid emit diesel exhaust ozon disrupt interact plant insect herbivor pest feed upon natur enemi herbivor eg parasitoid use eight field base ring emit regul quantiti diesel exhaust investig pollut individu combin alter attract parasit rate specialist parasitoid diaeretiella rapa aphid infest un infest brassica napus plant individu effect decreas rapa abund emerg respect compar ambient control condit diesel exhaust emit concomit rapa abund emerg increas respect relat control condit attract respons occur regardless whether plant infest aphid associ increas concentr aliphat glucosinol especi gluconapin butenyl glucosinol within b napus leav plant defens respons abil attract natur aphid enemi may benefici impact pollut exposur result demonstr import incorpor multipl air pollut consid effect air pollut plant insect interact
D000393;D001042
T131;T204
36,350,221
spontan prefer unpredict tempor conting agent motion naiv domest chick abil recogn anim agent base motion investig human anim alik movement multipl object interdepend human perceiv presenc social interact goal direct behaviour investig visual naiv domest chick respond agent whose motion reciproc conting space time ie time direct motion one object predict time direct motion anoth object present social aggreg stimulus three smaller disc repeat converg toward bigger disc move manner resembl mother hen chick versus control stimulus lack interact remark chick prefer stimuli time motion one object could predict object first demonstr sensit tempor relationship motion differ object naiv anim trait could basi develop percept social interact goal direct behaviour
D002645;D009039
T041;T012
36,350,219
limit metabol hered protocel univers core metabol could emerg thermodynam favour prebiot pathway origin life start h co synthesi amino acid mix fatti acid self assembl protocel favour warm anox condit address whether possibl protocel evolv greater metabol complex posit feedback involv nucleotid catalysi use mathemat simul model metabol hered protocel base branch point protometabol flux show nucleotid catalysi inde promot protocel growth outcom occur nucleotid direct catalys co fixat strong nucleotid catalysi pathway eg fatti acid amino acid general unbal metabol slow protocel growth competit catalyt function cell growth collaps autocatalysi nucleotid synthesi promot growth nucleotid also catalys co fixat autocatalysi alon lead accumul nucleotid expens co fixat protocel growth rate find offer new framework emerg greater metabol complex nucleotid catalys broad spectrum process co fixat hydrogen phosphoryl import emerg genet hered origin life
D058045;D040941
T044;T073;T075
36,350,218
social phenotyp depend select social environ wild great blue tit experiment studi grow evid individu activ assess match phenotyp environ make habitat choic decis call match habitat choic howev knowledg studi consid social environ may interact social phenotyp determin habitat choic despit habitat choic inher social process grow evid individu variat sociabl conduct experi use wild great blue tit understand bird integr social phenotyp social environ choos feed use programm feeder record social interact estim social phenotyp ii experiment manipul local densiti experienc bird differ social phenotyp track feeder usag estim social environ social phenotyp predict feeder choic feed behaviour social environ social phenotyp predict feeder usag bird decis remain particular social environ depend social phenotyp contrast feed behaviour respons social environ depend social phenotyp result provid rare evid match habitat choic shed light depend habitat choic individu differ social phenotyp
D020308
T012
36,350,217
antigen escap acceler presenc immunocompromis host repeat emerg sar cov escap mutant host immun obstruct contain current pandem pose serious threat human prolong infect immunocompromis patient receiv increas attent driver immun escap accumul evid suggest viral genom divers emerg immun escap mutant promot immunocompromis patient howev immunocompromis patient compris small proport host popul whether signific impact antigen evolut popul level unknown consid evolutionari epidemiolog model combin antigen evolut epidemiolog dynam appli model heterogen host popul studi impact immunocompromis host evolutionari dynam pathogen antigen escap host immun deriv analyt formula speed antigen evolut heterogen host popul found even small number immunocompromis host popul signific acceler antigen evolut result demonstr immunocompromis host play key role viral adapt popul level emphas import critic care surveil immunocompromis host
D000088603;D000086382
T047;T067
36,350,216
tidetre bayesian phylogenet framework estim singl cell tree popul dynam paramet genet lineag trace data develop organ tissu dictat elabor balanc cell divis apoptosi differenti cell popul dynam quantifi dynam propos phylodynam infer approach base singl cell lineag record data develop bayesian phylogenet framework time scale development tree tidetre use lineag record data estim time scale singl cell tree implement tidetre within beast enabl joint infer time scale tree cell popul dynam valid tidetre use simul show perform improv includ multipl independ sourc inform infer frequenc edit outcom experiment replic benchmark tidetre state art method show compar perform term tree topolog plus direct assess uncertainti co estim addit paramet demonstr tidetre use practic analys public dataset contain lineag data approxim stem cell coloni estim time scale phylogeni coloni well cell divis apoptosi rate under growth dynam coloni envis tidetre find broad applic analysi singl cell lineag trace data improv understand cellular process develop
D008957
T170
36,350,215
phylogenom reveal deep relationship diversif within phylactolaem bryozoan bryozoan most sessil coloni invertebr inhabit kind aquat ecosystem extant bryozoan speci fall two clade one phylactolaemata exclus freshwat clade phylogenet relationship within class phylactolaemata long controversi owe limit distinguish characterist reflect evolutionari relationship present first phylogenom analysi phylactolaemata use transcriptom data combin dens taxon sampl six famili better resolv interrelationship estim diverg time use maximum likelihood bayesian infer approach recov robust phylogeni phylactolaemata interfamili relationship fulli resolv show stephanellida sister taxon phylactolaem confirm lophopodida repres second offshoot within phylactolaem tree plumatella fruticosa clear fall outsid plumatellida previous investig suggest instead cluster pectinatellida cristatellida sister taxon fredericellida result demonstr cryptic speciat like f sultana two speci plumatella p repen p casmiana diverg time estim show phylactolaemata appear end ediacaran start diverg silurian although confid interv larg node radiat extant phylactolaem famili occur main palaeogen neogen highlight post extinct diversif
D017753;D002013
T070;T204;T082
36,350,213
assess relat import bacteri resist persist hyper mutat antibiot treatment failur curb rise threat antimicrobi resist need understand rout antimicrobi treatment failur bacteria surviv treatment use genet phenotyp mechan diminish effect antimicrobi assembl empir data show exampl pseudomona aeruginosa infect frequent contain persist transient non grow cell unaffect antibiot ab hyper mutat mutant elev mutat rate thus higher probabl genet resist emerg resist persist hyper mutat dynam difficult disentangl experiment henc use stochast popul model determinist fit calcul investig relat import genet phenotyp mechan immedi treatment failur establish prolong chronic infect find persist caus hidden treatment failur low cell number antimicrobi concentr prevent growth genet resist cell persist cell regrow treatment discontinu allow resist evolut absenc ab lead differ mutat rout treatment relaps infect contrast hyper mutat facilit resist evolut treatment rare contribut treatment failur find highlight time concentr depend differ bacteri mechan escap ab kill consid design failur proof treatment
D000900;D001424
T121;T047;T195
36,350,212
great tit differ glucocorticoid plastic respons spring temperatur fluctuat environment temperatur affect energi metabol stimul express revers phenotyp plastic vertebr behaviour physiolog trait chang circul concentr glucocorticoid hormon often underpin environment induc phenotyp plastic ongo climat chang predict increas fluctuat environment temperatur global make imper determin stand phenotyp variat glucocorticoid respons free live popul evalu potenti cope via plastic evolutionari chang use reaction norm approach repeat sampl wild great tit parus major individu circul glucocorticoid concentr reproduct across five year quantifi individu variat glucocorticoid plastic along environment temperatur gradient expect baselin stress induc glucocorticoid concentr increas lower environment temperatur popul within individu level moreov provid uniqu evid individu differ signific plastic respons temperatur gradient glucocorticoid trait display greater plastic other averag concentr degre plastic covari baselin glucocorticoid indic two reaction norm compon link henc individu variat glucocorticoid plastic respons key environment factor exist wild vertebr popul repres crucial step assess potenti endur temperatur fluctuat
D005938;D046109
T125;T039;T012;T109
36,350,211
risk drug resist long act antimicrobi therapi emerg drug resist antimicrobi therapi major global health problem especi chronic infect like human immunodefici virus hepat b c tuberculosi sub optim adher long term treatment import contributor resist risk new long act drug develop week month less frequent dose improv adher may lead long term exposur intermedi drug level studi analys effect dose frequenc risk resist evolv time vari drug level find long act therapi increas decreas littl effect resist depend sourc pre exist de novo degre resist rate drug absorpt clearanc long act therapi rapid drug absorpt slow clearanc strong wild type inhibit tend reduc resist caus partial resist strain earli stage treatment even improv adher howev subpopul microb persist reactiv sub optim treatment longer act therapi may substanti increas resist risk result show drug kinet affect select resist complic manner pathogen specif model need evalu benefit new long act therapi
D015658;D014376;D000890
T121;T047
36,350,210
priorit pollin pest wild bee import beetl damag watermelon yield insect pest pollin interact direct indirect affect crop product howev impact interact market yield littl known thus evalu interact pest pollin need best priorit manag effort year evalu impact pollin visit andor beetl acalymma vittatum infest fruit set yield seedless watermelon product test main effect pollin visit two eight honeybe visit two wild bee visit hand pollin open pollin cross wild manag pollin visit two four honeybe visit two four wild bee visit hand pollin open pollin vari beetl infest level beetlespl year wild bee contribut signific high fruit yield exclus visit wild bee increas yield factor compar honeybe pollin signific factor fruit set market yield even compar vari beetl infest level data advoc repriorit manag conserv protect wild bee pollin could critic avoid pest damag ensur high yield
D001517;D029773
T168;T002;T204
36,350,209
marin heatwav differ intens lead distinct pattern seafloor function marin heatwav mhws increas frequenc intens due climat chang sever well document effect heatwav communiti structur exist exampl effect function speci communiti ecosystem remain scarc test effect short term moder strong mhws macrofauna bioturb associ solut flux exampl ecosystem function also measur macrofaun excret rate assess effect temperatur macrofauna metabol experi use unmanipul sediment core natur anim communiti collect muddi locat depth northern baltic sea despit mechanist effect bioturb remain unchang treatment signific differ oxygen consumpt solut flux excret biogeochem biolog process boost moder heatwav wherea biogeochem cycl seem decreas strong heatwav prolong moder heatwav could possibl lead resourc deplet primari product meet demand benthic consumpt contrast decreas degrad activ strong heatwav could lead build organ materi potenti hypoxia strong variabl complex respons highlight context depend process complic futur predict
D017753;D057231
T070;T082
36,350,208
transport symbiont encod cellulas gill gut shipworm via enigmat duct deshay year mysteri solv shipworm bivalvia teredinida princip consum wood marin environ like wood eat organ digest wood aid cellulolyt enzym suppli symbiot bacteria howev shipworm symbiot bacteria found digest system instead locat intracellular gland deshay special tissu found within gill independ demonstr symbiont encod cellulolyt enzym present digest system gill two shipworm speci bankia setacea lyrodus pedicellatus confirm enzym transport gill lumen gut howev mechan enzym transport gill gut remain incomplet understood recent mechan propos enzym transport within bacteri cell expel gill transport mouth ciliari action branchial food groov use situ immunohistochem method provid evid differ mechan shipworm b setacea cellulolyt enzym transport via duct deshay enigmat structur first describ year ago whose function remain unexplain
D044602;D049872
T116;T126;T169;T204
36,350,207
greater variabl rhesus macaqu macaca mulatta endocrani volum among male femal greater male variabl gmv hypothesi propos trait variabl among male femal support numer empir studi interest gmv also observ human brain size intern brain structur pattern may implic sex bias neurolog psychiatr condit better understand neuroanatom variabl non human primat may illumin whether certain speci appropri model condit test sex differ variabl endocrani volum ecv proxi brain size sampl rhesus macaqu macaca mulatta larg pedigre free rang popul also examin compon phenotyp varianc addit genet residu varianc teas apart potenti driver sex differ variabl result suggest male exhibit variabl ecv pattern reflect either balancingdisrupt select male behaviour associ altern male mate strategi sex chromosom effect associ mosaic pattern x chromosom gene express femal rather extend neurodevelop among male repres evid gmv brain size non human primat speci highlight potenti rhesus macaqu model sex bias brain base disord
D012730;D012098
T026;T081;T040;T079
36,350,206
evolut genom basi plant penetr ovipositor key morpholog trait herbivor drosophilida herbivor insect extraordinarili divers yet found one third insect order skew may result barrier plant colon coupl phylogenet constraint plant colon adapt plant penetr ovipositor howev one trait surmount host plant physic defenc may evolutionarili labil ovipositor dens line hard bristl evolv repeat herbivor lineag includ within drosophilida howev evolut genet basi innov well studi focus evolut trait scaptomyza genus sister hawaiian drosophila contain herbivor clade phylogenet approach reveal ovipositor bristl number increas herbivori evolv scaptomyza lineag genom wide associ studi dissect genom architectur variat ovipositor bristl number within flava top associ variant enrich transcript repressor strongest associ includ gene contribut peripher nervous system develop individu genotyp support associ variant upstream gi neural develop gene contribut gain bristlesmajor allel result suggest regulatori variat involv conserv development gene contribut key morpholog trait involv plant colon
D018428
T204
36,350,205
natur allel doa locus underpin evolutionari chang drosophila lifespan fecund evolv resequ e amp r studi drosophila melanogast identifi mani candid loci under evolut age life histori experi valid effect candid remain rare recent e amp r studi identifi sever allel lammer kinas darken apricot doa candid evolutionari chang lifespan fecund use two complementari approach confirm function role doa life histori evolut first use transgen rnai studi effect doa whole gene level ubiquit silenc express adult fli reduc lifespan fecund indic pleiotrop effect second character segreg variat doa examin four candid singl nucleotid polymorph snps doa use genet associ approach three candid snps effect qualit consist expect base e amp r studi doa pleiotrop affect lifespan late life fecund doa affect lifespan fecund doa affect late life fecund lifespan final last candid allel doa also affect lifespan opposit direct predict
D000068219;D029721
T168;T116;T123;T002
36,350,204
evolutionari kuramoto dynam biolog system varieti time keep mechan rang molecular clock within cell complex interconnect unit across entir organ suprachiasmat nucleus compris interconnect oscillatori neuron serv master clock mammal ubiqu system indic evolutionari benefit outweigh cost establish maintain littl known process evolutionari develop begin address shortfal introduc analys new evolutionari game theoret framework model behaviour evolut system coupl oscil oscil character pair dynam behaviour dimens phase communic strategi along evolut occur measur success mutat compar benefit synchron balanc cost connect oscil despit simpl set model exhibit non trivial behaviour mimick sever differ classic game prison dilemma snowdrift game coordin game landscap oscil chang time across mani situat find surpris simpl character synchron connect communic benefit synchron greater twice cost system evolv toward complet communic phase synchron
D005716;D005075
T045;T170
36,350,203
high dispers rate hybrid drive expans maladapt hybrid hybrid nativ invas speci major caus biodivers loss spread rapid even hybrid reduc fit paradox suggest hybrid greater dispers rate non hybrid individu yet mechan empir test anim popul test non nativ genet introgress increas reproduct dispers use human mediat hybrid zone nativ cutthroat trout lt gt oncorhynchus clarkii lt gt invas rainbow trout lt gt oncorhynchus mykiss lt gt larg connect river system quantifi propens individu migrat natal rear habitat migrat reproduc non natal habitat stray joint probabl dispers function genet ancestri hybrid trout predomin non nativ rainbow trout ancestri like migrat juvenil stray adult overal hybrid greater rainbow trout ancestri time like dispers nativ hybrid trout small amount rainbow trout ancestri result show genet basi increas dispers hybrid like contribut rapid expans invas hybrid speci manag action decreas probabl hybrid dispers may mitig harm effect invas hybrid nativ biodivers
D017683;D017686
T013
36,350,202
sexual select male femal function monoeci dioecious popul broadleaf arrowhead sagittaria latifolia direct measur sexual select plant rare complic immobl modular growth plant instantan measur fit typic scale size covari size mate success could obscur detect sexual select measur magnitud sexual select monoeci dioecious popul clonal plant sagittaria latifolia use bateman gradient ss gradient calcul use parentag analysi residu regress account effect shoot clone size mate reproduct success popul greater promiscu via male function via femal function ii ss posit signific associ mate reproduct success male femal function moreov estim ss similar monoeci dioecious popul possibl non overlap femal male sex phase hermaphrodit latifolia reduc scope interfer sex function mate studi build previous studi select plant mate trait sexual select experiment condit show sexual select oper natur popul plant includ popul hermaphrodit
D034903
T002
36,350,201
associ total pancreat serum amylas enzymat activ insulin resist glucos insulin respons oral starch test mexican children littl known effect serum amylas enzymat activ glucos metabol investig associ serum amylas enzymat activ fast plasma glucos insulin resist ir plasma glucos insulin respons oral starch test ost mexican children
D007333;D055291
T046;T126;T116
36,350,200
neighbourhood socio econom environ predict adipos obes risk children two neighbourhood socio econom environ see associ obes older children adult littl known relationship younger children breastfeed import prevent adipos childhood relationship neighbourhood see unknown
D050154;D063766
T033;T047;T032
36,350,199
earli life exposur tobacco childhood adipos identifi window suscept earli life exposur tobacco associ obes suscept development period unknown
D014028;D063766
T033;T047;T069
36,350,198
motiv engag avoid convers weight adolesc parent perspect littl known parent adolesc motiv engag weight communic
D009042;D000294
T078;T055;T041;T080
36,350,196
first genet character setaria marshal nematoda spirurida reliabl dna barcod base mitochondri genet marker setaria marshal mosquito born filari nematod caus infect calv younger two year old present studi nematod obtain calf japan morpholog identifi marshal addit partial cytochrom oxidas subunit coi region bp analyz first time establish reliabl dna barcod nucleotid sequenc coi ident among seven worm obtain coi region use marker speci discrimin case marshal sinc nucleotid variat observ closest congen setaria cervi bp suffici allow speci discrimin howev phylogenet relationship marshal congen unclear maximum likelihood tree found partial coi sequenc marshal analyz present studi match relev section complet mitochondri genom labiatopapillosa deposit intern nucleotid sequenc databas find suggest marshal misdiagnos labiatopapillosa previous studi crucial conduct accur morpholog analys obtain reliabl molecular inform regard setaria nematod
D017182;D017174;D009348
T204
36,350,195
identif express profil odor bind protein parasit wasp micropl pallidip use pacbio long read sequenc micropl pallidip szpligeti hymenoptera braconida import parasit wasp second third instar noctuid larva insect pest spodoptera exigua spodoptera litura spodoptera frugiperda insect pallidip chemosensori recognit system critic forag mate oviposit behavior odor bind protein obp import system pallidip determin studi use pacbio long read sequenc identifi pallidip unigen predict protein follow retriev possibl obp sequenc remov redund non full length eventu clone five obp sequenc mpobp mpobp mpobp mpobp mppbp bp size respect pallidip obp six conserv cystein residu phylogenet analysi reveal five obp locat differ branch phylogenet tree addit tissu express profil indic mpobp mppbp main express antenna male wasp mpobp mpobp mpobp main express antenna femal wasp mpobp also high express leg femal wasp tempor profil reveal express pallidip obp peak differ day emerg adulthood conclus identifi five novel odor bind protein pallidip demonstr biolog relev differ express pattern
D014863
T204
36,350,194
serolog diagnosi toxoplasmosi evalu commerci test recomlin toxoplasma igg immunoblot mikrogen base recombin antigen igg detect determin immun status toxoplasma gondii infect seroconvers main reli elisa techniqu necessari confirmatori test western blot studi evalu perform recomlin toxoplasma igg immunoblot ib recomlin mikrogen confirmatori test larg number sera total sera select patient previous analyz two elisa test architect abbott vida biomrieux ldbio toxo ii igg western blot wb ldbio ldbio sera classifi three group group includ sera without difficulti interpret igg result patient document past infect uninfect group includ sera difficulti interpret elisa result group includ sequenti sera pregnant women seroconvers
D014122;D014123
T047;T204
36,350,193
de novo transcriptom assembl identif g protein coupl receptor gpcrs two speci monogenean parasit fish genom resourc platyhelminth class monogenea scarc despit divers parasit speci high pathogen fish host work aim generat de novo assembl transcriptom two monogenean speci scutogyrus longicorni dactylogyrida rhabdosynochus viridisi diplectanida provid protocol cdna librari prepar low input sampl use singl cell transcriptom allow us work sub microgram amount total rna success transcriptom consist putat protein respect annot accord swiss prot pfam go kegg cog databas complet valu transcriptom evalu busco metazoa databas respect rang monogenean speci among annot larg number term relat g protein coupl receptor gpcrs found identifi gpcr like sequenc r viridisi longicorni includ famili member specif platyhelminth rhodopsin largest famili accord graf classif two putat melatonin receptor found longicorni repres first record group protein parasit platyhelminth forti gpcrs r viridisi longicorni absent vertebrata might potenti drug target present studi provid first public avail transcriptom monogenean subclass monopisthocotylea serv use genom dataset function genom research import group parasit
D010271;D010986;D014200
T204
36,350,192
genet character cryptosporidium spp hotan black chicken china reveal two novel subtyp cryptosporidium meleagridi total fecal specimen collect hotan black chicken farm southern xinjiang china test presenc cryptosporidium spp pcr small subunit ribosom rna ssu rrna gene overal infect rate cryptosporidium spp ten farm posit infect rate cryptosporidium spp group higher chicken group cryptosporidium meleagridi n c baileyi n confirm sequenc analysi total c meleagridi posit specimen subtyp success gp gene includ one known subtyp iiibagr n two novel subtyp name iiibagr n iiibagr n result show infect cryptosporidium spp hotan black chicken common area distribut c meleagridi subtyp region characterist
D003458;D003457
T047;T204
36,350,173
perin injuri via person watercraft hydrostat jet case report traumat injuri result person watercraft hydrostat jet expect increas person watercraft afford portabl use increas wide rang local
D000058
T037
36,350,172
pediatr penetr neck trauma result metal boat cleat case report clinic decis make pediatr neck trauma challeng data report spars present case report show current recommend manag pediatr neck injuri
D019838;D014950
T037
36,350,171
bison gore result abdomin eviscer cervic fractur case report handl livestock danger livestock relat injuri increas
D016164;D016103;D019838;D007035
T033;T015;T037
36,350,170
reliabl valid japanes version attitud relat trauma inform care artic scale trauma inform care recommend avoid inadvert retraumat patient health care provid psychometr evalu trauma inform care instrument need japanes version attitud relat trauma inform care artic scale yet psychometr valid
D015203
T062;T081;T080
36,350,169
hospit specif data dictionari impact compet level data collect nation survey trauma registri staff task high qualiti data collect support program requir hospit specif data dictionari increas use ensur accur data collect yet unknown resourc impact trauma registri team compet data collect
D014193;D006761
T073;T093
36,350,168
pelvic compress devic binder applic train medic student manikin studi correct applic extern pelvic compress devic binder crucial manag multitrauma patient suspect pelvic fractur control hemorrhag yet lack practic train standard pelvic compress devic applic medic school educ
D013337;D010384;D000066908;D016887
T065;T023;T097;T061
36,350,166
trauma death emerg depart time paus promot acknowledg uniti sympathi end life wit death difficult emot drain health care worker present risk factor burnout practic ritual paus patient death recogn patient person reflect acknowledg health care team emerg intervent well studi trauma
D002055
T048
36,350,164
valid trauma inform care instrument emerg depart environ transit secondari environ trauma inform care paradigm care requir health care practition understand multipl type trauma effect trauma survivor incorpor knowledg practic howev psychometr robust instrument evalu trauma inform care none appli trauma patient set
D004636;D006282
T097;T073;T093
36,350,136
phenol phthalat effect thyroid hormon level pregnanc reli vitro assay advers outcom pathway inform epidemiolog analysi studi character associ phenol phthalat thyroid hormon pregnanc produc inconsist result diverg may part attribut fals posit due multipl comparison test larg number chemic measur error studi reli small number biospecimen despit high intra individu variabl urinari chemic metabolit concentr
D000073931;D010795;D007455
T123;T121;T067;T109;T196
36,350,115
share properti gene transfer agent core gene reveal compar genom alphaproteobacteria gene transfer agent gtas phage like particl transfer piec cellular genom dna cell homologu rhodobact capsulatus gta rcgta structur gene wide distribut alphaproteobacteria particular well conserv order rhodobacteral possibl reason widespread conserv still discuss suggest alphaproteobacteri element origin prophag present ancestr bacterium subsequ evolv gta wide maintain extant descend lineag analys genom properti might relat conserv alphaproteobacteri gtas reveal chromosom locat gta gene cluster bias primarili occur lead strand dna replic larg distanc long repetit element thus region lower plastic area extrem gc skew also accumul core gene extrem gc skew region aris preferenti use codon excess g c distinct phenomenon elev gc content previous found associ gta gene observ properti along high level conserv show gta gene share multipl featur core gene examin lineag alphaproteobacteria
D020561;D016354
T007
36,350,068
assess fat fraction tongu soft palat pharyng wall parapharyng fat pad goos dixon method point dixon method wide use assess fat fraction ffs magnet reson imag mris tongu pharyng wall surround tissu patient obstruct sleep apnea osa howev method semiquantit suscept b field inhomogen r confound factor use method although sever studi shown patient osa increas fat deposit around pharyng caviti conflict find also report studi discrep necessit examin ff estim method use earlier studi seek accur method measur ffs
D010160;D020181
T023;T047
36,350,065
diagnost prognost valu isol combin mcm glypican express hepatocellular carcinoma novel immunosubtyp prognost model despit diagnost therapeut advanc hepatocellular carcinoma hcc remain lead caus morbiditymort worldwid retrospect studi investig isol combin mini chromosom mainten complex compon mcm glypican gpc immunohistochem ihc express hcc novel hcc immunosubtyp model base combin mcmgpc express introduc test comparison prognost variabl surviv outcom seventi six hcc patient underw hepatectomi enrol collect clinicopatholog laboratori year surviv data ihc appli hcc tissu microarray prepar section use anti mcm gpc ihc score divid hccs mcm high mcm low express gpc posit gpc negat express combin score model immunosubtyp mcm highgpc posit mcm lowgpc posit mcm highgpc negat mcm lowgpc negat statist kaplan meier surviv analys perform use spss version mcm express hccs mcm high hccs signific associ lack tumor capsul portal vein thrombosi high grade advanc stage child pugh score b c p tendenc multipl metastasi solid growth pattern shorter overal surviv os diseas free surviv dfs gpc positv hccs signific associ multipl higher alfa fetoprotein p tendenc shorter os dfs among isol combin express immunosubtyp mcm highgpc posit hccs worst prognosi shortest os dfs wherea mcm lowgpc negat immunosubtyp show best prognosi longest os dfs mcm defin diagnost prognost marker potenti therapeut target hcc novel mcmgpc immunosubtyp model provid prognost indic stratif criteria patient hcc
D006528;D008113
T191
36,350,024
dysphagia obvious caus globus pharyngeus globus pharyngeus globus sensat ordinari ent referr compris persist intermitt painless feel lump foreign bodi throat may outlin tighten choke sensat usual long last tendenc recur establish guidelin concern diagnosi treatment histori clinic examin repres essenti element enabl practition narrow differenti diagnosi consid red flag therapeut trial use ppi recommend initi first line treatment absenc red flag paraclin assess propos nonrespons patient manag clinic condit consist reassur offer speech therapi refractori case
D003680
T047
36,350,023
risk assess manag epidemiolog social accept risk well known concept medicin epidemiolog approach intend ration measur risk measur make possibl communic patient popul risk occurr event howev often difficult estim accur probabl occurr advers event therefor uncertainti addit notion risk easi grasp peopl risk perceiv differ one individu anoth percept understand depend psycholog social cultur histor polit factor understand social dimens risk clinic practic public health essenti implement effici risk manag
D012308;D011634
T058;T091
36,350,022
first epidemiolog evalu vaud colorect cancer screen program vaud colorect cancer crc screen program pioneer switzerland offer sinc choic biennial fecal immunolog test fit colonoscopi everi year age first epidemiolog evalu swiss crc screen program show increas uptak year equal distribut choic test region differ qualiti fit colonoscopi fulfil european norm high proport earli stage cancer stage met expect larg increas screen test limit colonoscopi capac lead interprofession discuss strategi priorit fit accompani addit orient tool within program public sensit reduc time taken perform fit posit colonoscopi
D055088;D015179
T060;T058;T191
36,350,021
ten year manual medicin unis retrospect illustr manual medicin consult exist canton vaud ten year develop within unis univers centr general medicin public health lausann long time consult one kind set univers set switzerland despit grow interest import develop german speak switzerland germani approach remain relat unknown patient therapist french speak canton birthday opportun put spotlight manual medicin retrac histori establish consult canton illustr practic clinic vignett
D011634
T091
36,350,020
covid screen strategi workplac canton vaud lesson repetit screen enterpris one measur recommend switzerland fight covid canton vaud compani particip program small medium size enterpris sar cov posit rate test perform imposs telework reduct transmiss main motiv join program facilit element avail canton medic offic exist starter kit support hierarchi within compani main obstacl arriv vaccin multipl screen provid workload program pragmat action tool compani rather popul base strategi
D017132;D000086382
T047;T067;T082
36,350,019
optim therapeut adher ambulatori care link patient home care nurs pharmacist physican world health organ consid medic safeti one main area improv patient safeti treatment adher dynam process evolv time life circumst paramount import sinc depend number factor health care profession need approach comprehens patient follow articl describ tool avail general practition specialist physician collabor pharmacist home care nurs optim medic adher ambulatori set interprofession approach provid allow adequ support patient empower treatment adjust optim base share common goal
D058005;D006699
T058;T097
36,350,010
clinic manag surviv outcom patient differ molecular subtyp diffus glioma china multicent retrospect studi cgga aim summar clinicopatholog characterist prognost featur various molecular subtyp diffus glioma dgs chines popul
D005909;D001932;D005910
T191
36,350,006
preoper ultrasound combin routin blood test predict malign risk pancreat cystic neoplasm accur preoper identif benign malign pancreat cystic neoplasm pcn may help clinician make better intervent choic essenti individu treatment
D011285;D010190
T121;T191;T109
36,350,005
antifibrinolyt therapi aneurysm subarachnoid haemorrhag rebleed import caus death disabl peopl aneurysm subarachnoid haemorrhag rebleed probabl relat dissolut blood clot site aneurysm ruptur natur fibrinolyt activ review updat previous publish cochran review
D013345;D000933;D002545;D006849
T121;T033;T019;T047;T046
36,350,002
epidemiolog characterist genet alter adult diffus glioma east asian popul understand racial specif diseas adult diffus glioma common primari malign tumor central nervous system critic step toward precis medicin comprehens review studi glioma east asian popul ancestri group clarifi racial differ term epidemiolog genom characterist overal observ lower glioma incid east asian white notabl patient glioblastoma signific younger age onset longer overal surviv white multipl genom wide associ studi various cohort reveal singl nucleotid polymorph associ overal subtyp specif glioma suscept notabl risk loci p q q share patient east asian white ancestri wherea loci predomin particular popul instanc risk loci p q p report east asian wherea risk loci q p q report studi white patient although somat mutat profil glioma east asian non east asian broad consist lower incid egfr amplif glioblastoma higher incid pq idh tert tripl negat low grade glioma observ east asian cohort summar larg scale diseas surveil germlin somat genom studi review reveal uniqu characterist adult diffus glioma among east asian guid clinic manag polici design focus patient east asian ancestri
D005909;D005910
T191
36,350,001
radiotherapi delay malign transform prolong surviv patient idh mutant glioma idh mutant lower grade glioma lggs grade eventu transform secondari grade astrocytoma saidhmutg sought describ transform time risk factor outcom malign transform idh mutant lggs
D001932;D005910;D009837;D001254;D005909
T191
36,349,972
fight evolut turkish govern intensifi attack theori evolut academ communiti ralli push back research recount decid join
D011057;D012108
T078;T090;T055;T097;T068;T057
36,349,914
metastasi direct therapi without androgen depriv therapi solitari oligorecurr prostat cancer controversi remain regard role metastasi direct therapi patient oligometastat prostat cancer sought character outcom metastasi direct therapi without concomit androgen depriv therapi specif subset patient solitari metastat lesion c cholin positron emiss tomographi imag whose primari tumor alreadi treat
D011471;D016634
T061;T191
36,349,908
ngs analysi reveal lactococcus garviea lg per lactococcus petauri trkiy lactococcus garviea lg per origin isol rainbow trout cultur cage locat turkish coast black sea whole genom sequenc lg per perform present studi complet genom lg per map refer genom l garviea gcf lactococcus petauri gcf total base pair respect lg per protein code gene rrna trna tmrna operon orthoani valu lg per l petauri gcf lg per l garviea gcf phylogenet tree generat whole genom sequenc wgs sever lactococcus speci found l petauri gca close relat lg per strain similar although l garviea lg per confirm l garviea base phenotyp biochem rrna sequenc wgs lg per strain reveal lg per l petauri use rrna base pcr detect approach lg per misdiagnos l garviea sinc rrna gene similar l garviea strain consequ rrna base pcr detect approach may adequ identif lactococcus genus first studi document presenc l petauri trkiy l garviea isol analys use wgs sinc issu might occur countri
D005393
T047
36,349,897
gut homeostasi glanc intestin rapid self renew organ part gastrointestin system major role absorb food deriv nutrient water process wast act barrier potenti harm substanc give brief overview primari function intestin structur lumin gradient along length discuss dynam intestin epithelium turnov mainten homeostasi final focus characterist function intestin mesenchym immun cell cell scienc glanc articl accompani poster aim present recent inform gut cell biolog physiolog provid resourc explor
D007413;D000078622
T168;T023;T024
36,349,842
sequel termin ideal analyt work stand consider distanc clinic realiti complet termin rare inde gap perhap best explor consid sequel instanc ex analyst ex patient becom nonsexu friend post treatment mean implic post termin friendship complex problemat edg serious difficulti potenti therapeut benefit deviat termin ideal illustr use unfinish stori good treatment yet defin end thus psychoanalyt model termin interrog complex treatment sequel patient analyst elucid
D011575;D011572
T061;T091
36,349,838
georg perec zeit raum creat space remembr georg perec memoir analysi scene stratagem part literari oeuvr character innov form address paradox task tell stori told life histori construct memori trace veil behind untim death parent world war ii memoir tell stori analysi adulthood jean bertrand pontali time perec struggl depress writer block beneath doubt tedious analyt routin perec present analysi space memori trace given new life histor past take place space walter benjamin call time space zeit raum time dream zeit traum space creat flash co incid dream wake histori creat space archiv memori trace transform present experi perec creat kind benjaminian dream space past deal fragment memori follow traumat loss signific distinct space discuss relat challeng repres traumat experi remain faith dreamlik fragment natur space
D004325;D004644
T184;T041
36,349,799
postnat deplet matern cell bias lymphocyt natur killer cell profil toward earli activ spleen matern cell transfer fetus gestat persist long birth progeni matern cell hypothes promot matur fetal immun system utero still signific gap knowledg potenti role birth provid insight matern cell postnat function role set transgen mous model specif elimin matern cell neonat diphtheria toxin inject confirm signific deplet spleen perform immunophenotyp spleen two week old pup mass cytometri pinpoint immun profil differ driven deplet matern cell earli postnat life observ heighten express marker relat activ matur natur killer cell popul hypothes result indic potenti postnat regul lymphocyt respons matern cell togeth find highlight immunolog influenc matern microchimer cell postnat possibl protect advers hypersensit reaction neonat crucial time new encount self environment antigen
D013601;D013154
T023;T025
36,349,679
syringocystadenoma papilliferum reveal year surgic treatment chronic ear cholesteatoma present unusu case literatur review syringocystadenoma papilliferum rare hamartomat adnex tumor appear main head neck region rare tumor may appear extern auditori canal describ case syringocystadenoma papilliferum extern auditori canal medlin databas studi present first report case syringocystadenoma papilliferum aris modifi radic mastoidectomi occur year ear surgeri year old man admit clinic complaint discharg left ear ear full hear loss symptom worsen year twelv year previous undergon modifi radic mastoidectomi bondi due cholesteatoma otoscop examin reveal otorrhea reddish mass measur cm aris tegmen tympanum fundus mastoid caviti surgic biopsi conduct local anesthesia medic outpati clinic reveal syringocystadenoma papilliferum tumor resect perform retroauricular approach bone attach tumor drill ear caviti cover mash split skin graft ear caviti heal tumor recurr observ month follow period case literatur analysi previous describ case led conclus case syringocystadenoma papilliferum extern auditori canal may associ differ medic histori age distribut origin syringocystadenoma papilliferum head neck region tubular adenoma may occur togeth syringocystadenoma papilliferum case malign transform syringocystadenoma papilliferum may occur extrem rare comput tomographi imag may predict malign tumor tumor specif extern auditori canal may occur modifi radic mastoidectomi middl ear surgeri
D000074009;D013544;D002781
T047;T191
36,349,678
cochlear implant child patau syndrom studi aim present first cochlear implant surgeri perform patient patau syndrom auditori brainstem respons test perform th month iii v wave db obtain right ear iii v wave db obtain left ear free field audiometri test done first year threshold valu cochlear implant found db meaning auditori integr scale test result meaning use speech scale test result cochlear implant observ found hear result good posit effect qualiti life
D019929;D003054;D013067
T061;T074;T041
36,349,677
heterotop pancrea middl ear case report heterotop pancrea congenit presenc pancreat tissu outsid normal locat absenc vascular anatom connect main pancrea knowledg case heterotop pancrea cyst middl ear report date studi report first case year old boy ectop pancrea area middl ear patient underw canal wall mastoidectomi tympanoplasti final diagnos ectop pancrea left middl ear year follow evid recurr residu diseas middl ear cleft mastoid found heterotop pancrea middl ear uncommon condit may present otorrhea aural full diagnosi usual straightforward histolog evalu resect specimen complement immun ohist ochem istri total excis lesion prefer avoid complic regular follow necessari due potenti risk recurr malign transform
D008416;D018424
T047;T023;T030
36,349,676
chronic nois affect middl ear reson absorb industri worker effect chronic nois middl ear fulli known studi aim evalu middl ear function metal worker expos chronic nois use wideband tympanometri
D004432;D007758
T023;T030
36,349,675
reliabl valid tinnitus handicap inventori clinic studi questionnair aim studi observ applic chines version tinnitus handicap inventori china tinnitus patient verifi reliabl valid
D014012
T184;T047;T037
36,349,674
incid benign paroxysm posit vertigo cours treatment follow mild head trauma worth look studi aim identifi incid benign paroxysm posit vertigo follow head trauma
D065635;D006259
T047;T037
36,349,673
fusion diffus weight magnet reson imag high resolut comput tomographi scan preoper tool classif middl ear cholesteatoma role imag cholesteatoma continu evolv excel boni detail provid high resolut comput tomographi high soft tissu identif cholesteatoma diffus weight magnet reson imag fusion highresolut comput tomographi diffus weight magnet reson imag combin advantag imag techniqu
D018424
T047
36,349,672
balloon dilat eustachian tube random control trial month follow obstruct eustachian tube dysfunct adult common purpos studi examin whether balloon dilat eustachian tube improv ventil middl ear among adult patient mild chronic eustachian tube dysfunct
D005064;D004427
T023;T047
36,349,671
balloon dilat eustachian tube chronic eustachian tube dysfunct retrospect studi patient eustachian tube dysfunct affect adult studi evalu effect balloon dilat eustachian tube treat nonselect patient eustachian tube dysfunct long term
D005064;D004427;D010033
T023;T047
36,349,670
manag complex jugular paraganglioma surgic resect outcom studi aim review tumor control cranial nerv function outcom patient complex jugular paraganglioma refin surgic strategi complex jugular paraganglioma
D016893;D005925;D010235
T047;T191;T020
36,349,669
acoust reflex surgic repair patient congenit aural atresia studi aim examin plastic nerv indirect acoust reflex surgic repair unilater congenit aural atresia
D019651;D000013
T061;T019
36,349,668
cerebrospin fluid gusher cochlear implant associ inner ear malform aim investig incid cerebrospin fluid gusher cochlear implant associ cerebrospin fluid gusher inner ear malform adult pediatr patient
D019929;D007758;D003054
T061;T023;T074