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biomedical-topic-categorization-validation

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36,301,023
hdac deplet amelior il trigger inflammatori respons mucus product nasal epitheli cell via activ sirtnf b signal allerg rhiniti ar frequent known chronic respiratori diseas global high preval pivot role histon deacetylas hdac multipl human diseas underlin numer studi nevertheless whether hdac implic ar remain elabor object current studi clarifi impact hdac ar
D016328;D065631
T129;T047;T116
36,301,022
brief research biophys studi anticanc behavior pt ii complex dnabsa bind molecular dock cytotox properti potent bident carrier ligand picolylamin pic use synthes pt ii complex know bioactiv anticanc properti reflect pass predict softwar dichloro pt ii complex pt pic cl pt hydrolyz diaqua complex pt pic oh pt synthes thiol contain pt ii complex pt pic l cys pt pt pic l ac l cy pt synthes pt obtain hydrolysi pt biomolecular interact bsa dna execut spectroscop method cytototox properti test mtt assay vitro biomolecular interact pt ii complex bsa dna investig differ spectroscop viscos measur method pharmacokinet pharmacodynam import conform chang bsa presenc drug candid studi frster reson energi transfer calcul synchron three dimension fluoresc spectroscop studi theoret approach optim structur highest occupi molecular orbit lowest unoccupi molecular orbit energi global reactiv paramet time depend densiti function theori molecular dock bsa dna execut strengthen support experiment observ vitro cytotox profil complex like anticanc activ level reactiv oxygen speci product brought consider cancer cell normal human embryon kidney cell line hek cytotox properti compar recogn anticanc drug cisplatin
D000970;D056831
T121;T104;T109
36,301,011
characterist anim model covid sever acut respiratori syndrom coronavirus sar cov causat agent coronavirus diseas covid consequenti pandem centuri threaten human health public safeti sar cov continu evolv mutat genom variant concern emerg world health organ r blueprint plan conven rang expert group develop anim model covid core requir prevent control sar cov pandem anim model construct techniqu develop sar cov mer cov pandem rapid deploy appli establish covid anim model date larg number anim model covid includ mice hamster mink nonhuman primat establish infecti diseas produc uniqu manifest accord characterist pathogen mode infect classifi anim model resourc around infect rout sar cov summar characterist anim model construct via transnas local simul transmiss rout infect
D000086382;D065207
T047;T005;T067
36,301,008
like game chess everi move matter role antibodi myasthenia gravi treatment landscap symptom diseas pathophysiolog myasthenia gravi mg vari consider patient individu prefer prioriti add need individu treatment autoimmun diseas research mg grown substanti recent year new treatment potenti effect well toler address trade choos either efficaci toler select treatment promis investig treatment may becom avail futur may allow patient ever achiev asymptomat state ultim goal turn abnorm antibodi product
D011950;D009157
T047;T116;T192
36,301,003
impact hospit administ extend releas naltrexon readmiss rate patient alcohol use disord pilot studi object evalu impact extend releas er intramuscular naltrexon readmiss rate hospit patient alcohol use disord aud
D009271;D000437
T121;T048;T109
36,301,002
newli develop imag fusion algorithm cect imag ct imag feasibl studi cancer case rise world cancer treatment benefit earli accur diagnosi percutan needl biopsi guidanc ct imag common method obtain tumor sampl accur diagnosi howev due lack vascular inform ct imag biopsi procedur great risk especi tumor surround vessel studi biomechan model surfac elast registr base fusion algorithm develop map vessel contrast enhanc ct imag liver lung correspond ct imag radiologist could observ vessel ct imag biopsi procedur risk decreas develop algorithm test group lung data group liver data result show fusion error mean standard deviat mm portal vein hepat vein pulmonari arteri pulmonari vein respect accuraci method satisfi clinic applic
D000465;D008099
T023;T170
36,300,996
overlap pattern suicid attempt non suicid self injuri adult prospect clinic cohort studi object overlap non suicid self injuri nssis suicid attempt sas observ young cohort robust prospect studi adult compar year outcom adult differ self harm pattern nssi nssi sa sa
D013406;D016728
T055;T037;T048
36,300,995
safeti ketamin augment monoamin oxidas inhibitor treatment resist depress systemat literatur review case seri object ketamin increas prescrib treatment resist depress trd often add regular antidepress augment ketamin monoamin oxidas inhibitor maoi advis practic might increas blood pressur caus serotonin syndrom despit potenti relev patient littl known actual side effect combin use summar literatur safeti add result case seri
D020230;D061218;D064420
T046;T037;T048
36,300,994
relationship premenstru dysphor disord bipolar disord systemat review object sinc depress repres predomin mood polar bipolar disord bd preval rate diagnosi premenstru dysphor disord pmdd women bd diagnosi bd women pmdd deserv systemat review
D065446;D001714;D011293
T047;T048
36,300,991
character fourier transform infrar caviti ring spectroscopi optic feedback caviti enhanc absorpt spectroscopi instrument analysi ammonia bioga biomethan novel traceabl analyt method refer gas standard develop detect trace level ammonia bioga biomethan work focus ammonia amount fraction upper limit level mg correspond approxim mol mol specifi en applic spectroscop analyt method fourier transform infrar spectroscopi caviti ring spectroscopi optic feedback caviti enhanc absorpt spectroscopi investig techniqu exhibit necessari ammonia sensit requir mol mol amount fraction month stabil studi refer gas mixtur mol mol ammonia methan synthet bioga also report
D000641;D056804
T121;T197;T109
36,300,974
neonat docosahexaeno acid preterm infant intellig year docosahexaeno acid dha compon neural tissu accret brain greatest final trimest pregnanc infant born week gestat receiv normal suppli dha effect defici subsequ cognit develop well understood
D001997;D004281;D007234;D007360;D003071
T123;T121;T109;T033;T100;T047;T041
36,300,973
racial ethnic differ bystand cpr wit cardiac arrest differ incid cardiopulmonari resuscit cpr provid bystand contribut surviv dispar among person hospit cardiac arrest critic understand whether incid bystand cpr wit hospit cardiac arrest home public set differ accord race ethnic group person cardiac arrest order inform intervent
D016887;D006630;D058687;D044465;D044383
T061;T098;T046
36,300,965
cardiopulmonari resuscit train select rhode island high school descript studi fewer peopl hospit cardiac arrest surviv chanc surviv tripl effect bystand cardiopulmonari resuscit cpr major state includ rhode island requir high school cpr train yet impact well studi question redcap survey regard cardiac arrest prepared cpr educ barrier cpr train email high school staff rhode island respons report school taught cpr felt import student cpr certif barrier includ time budget materi felt student would abl perform high qualiti cpr proper use defibril despit law requir cpr train belief school staff import cpr train major student receiv cpr train staff report student abil perform effect cpr use defibril
D016887;D058687
T061;T046
36,300,962
brucella speci stain gram posit rod gram posit cocci chain two case brucellosi identifi hospit rhode island case organ isol blood cultur bacteria appear classic textbook descript brucella spp short gram negat rod instead gram posit rod gram posit cocci chain observ due atyp gram stain morpholog brucella spp initi consid possibl pathogen antimicrobi prophylax offer technologist expos organ
D006095;D002002
T007
36,300,961
diffus alveolar hemorrhag secondari human metapneumovirus pulmonari infect year old man present week flu like symptom hypoxia fever respiratori viral panel posit human metapneumovirus initi chest imag show left lower lobe opacif suggest bacteri superimpos viral pneumonia despit antibiot patient becam tachycard increas hypox requir l high flow nasal cannula repeat imag demonstr worsen left lower lobe process elect bronchoscopi bronchoalveolar lavag reveal hemorrhag subsequ autoimmun bacteri fungal workup negat patient diagnos diffus alveolar hemorrhag dah secondari human metapneumovirus pneumonia dah defin bleed alveolar space lung process carri high rate morbid mortal dramat name often associ hemoptysi dah may present clinic subtl nonspecif featur varieti altern etiolog consid present case dah secondari human metapneumovirus hmpv promot discuss etiolog dah asid system vascul
D029121;D008171;D011024
T005;T047
36,300,960
treat target era target immunosuppress agent ibd manag advent biolog agent treatment patient inflammatori bowel diseas ibd chang manag symptom achiev remiss diseas diseas remiss associ better outcom symptomat care alon treat target paradigm provid target serv surrog achiev diseas remiss import target endoscop mucos heal target includ symptomat respons symptomat remiss biomark normal normal patient qualiti life target reach via util biolog medic may modifi substitut goal met ibd qorus repres nation collabor academ ibd center privat gastroenterolog practic use treat target approach patient center communic method provid better care patient suffer ibd
D003093;D003424;D015212
T047
36,300,959
fmt next narrat review fecal microbiota transplant clostridioid difficil infect inflammatori bowel diseas fecal microbiota transplant fmt increas employ treatment option clostridioid difficil infect cdi grow data support safeti effect patient concurr inflammatori bowel diseas ibd given alter gut microbiom associ ulcer coliti uc crohn diseas cd use fmt treatment ibd anoth area activ investig narrat review highlight evid use fmt treatment cdi patient ibd well ibd alon provid insight futur microbiom therapeut
D016360;D003015;D015212
T047;T007;T037
36,300,958
extraintestin manifest inflammatori bowel diseas inflammatori bowel diseas ibd primarili diseas digest tract system though may affect organ system outsid intestin extraintestin manifest eim occur one third patient crohn diseas ulcer coliti common eim involv dermatolog musculoskelet manifest eim may either parallel intestin inflamm complet independ diseas activ physician awar eim think systemat evalu patient ibd near everi organ involv multidisciplinari treatment approach undertaken improv outcom qualiti life
D015212;D003093
T047
36,300,957
prevent care health mainten patient inflammatori bowel diseas health mainten patient inflammatori bowel diseas ibd essenti order achiev clinic endoscop remiss mani patient requir treatment steroid immunomodul biolog small molecul place higher risk serious infect well certain malign advers event prevent vaccin adher cancer screen guidelin make prevent care health mainten patient popul crucial gastroenterologist take proactiv role health care mainten collabor patient primari care provid aim articl review provid guidanc prevent care health mainten patient ibd includ vaccin cancer screen bone health nutrit mental health assess well smoke cessat
D015212;D016540
T055;T047
36,300,950
decatungst catalyz photochem acetyl c sp h bond direct acetyl inert c sp h bond develop catalyz decatungst visibl light irradi follow radic addit disassoci phenylsulfonyl ethanon oxim reaction display site select multipl c sp h bond without prefunction direct group various function group well toler natur molecul structur feasibl cf modifi phenylsulfonyl ethanon oxim discov necessari enhanc electrophil imin lower c bond cleavag energi
D010091
T109
36,300,922
vascular transcriptom investig endotheli activ vascular dysfunct use blood outgrowth endotheli cell organ chip rna sequenc vascular organ chip vessel chip technolog signific impact abil model microphysiolog vasculatur biomimet platform garner signific interest scientist pharmaceut compani drug screen model howev model still lack inclus patient specif vasculatur form patient deriv endotheli cell blood outgrowth endotheli cell patient blood deriv endotheli progenitor gain interest vascular biolog communiti autolog endotheli cell altern also incorpor vessel chip model next generat sequenc techniqu like rna sequenc unlock potenti person vessel chip discern patient specif hallmark endotheli dysfunct present detail protocol isol blood outgrowth endotheli cell patient blood sampl cultur microfluid vessel chip isol prepar rna individu vessel chip sequenc perform differenti gene express bioinformat analys vascular dysfunct endotheli activ pathway method focus specif identif pathway gene involv vascular homeostasi patholog easili adapt requir system wiley period llc basic protocol isol blood outgrowth endotheli cell patient blood basic protocol cultur blood outgrowth endotheli cell microfluid vessel chip basic protocol isol rna autolog vessel chip basic protocol differenti gene express bioinformat analys endotheli activ pathway
D042783;D059467
T081;T025;T086
36,300,920
fret flim determin protein interact membran topolog enzym complex determin protein protein interact vital gain knowledg cellular metabol process includ enzym complex metabolon frster reson energi transfer fluoresc lifetim imag microscopi fret flim advanc imag methodolog allow quantit detect protein protein interact method protein interest interact studi fuse differ fluorophor enhanc green fluoresc protein egfp donor molecul monomer red fluoresc protein mrfp acceptor molecul energi transfer two fluorophor group occur effici protein interest close physic proxim around nm therefor like interact fret flim measur decreas excit state lifetim donor fluorophor egfp without presenc acceptor mrfp therefor give inform protein protein interact membran topolog test protein describ product fluoresc protein fusion fret flim analysi tobacco leaf epiderm cell use agrobacterium mediat plant transform fret flim data acquisit analysi protocol plant cell protocol applic adapt membran solubl protein differ cellular local author current protocol publish wiley period llc basic protocol protein express tobacco leaf cell via transient agrobacterium mediat plant transform basic protocol fret flim data acquisit analysi
D031541;D005456
T130;T059
36,300,918
analyz brainstem circuit respiratori chemosensit freeli move mice regul system pco life preserv homeostat mechan medulla oblongata retrotrapezoid nucleus rtn rostral medullari raph propos co chemosensori nuclei mediat adapt respiratori chang hypercapnia also induc activ expir adapt chang thought control later parafaci region pf l use gcamp express head mount mini microscop imag ca activ nuclei awak adult mice hypercapnia activ pf l support role homogen neuron popul drive activ expir data show chemosensori respons rtn raph differ tempor characterist sensit co rais possibl nuclei act coordin way generat adapt ventilatori respons hypercapnia analysi revis understand chemosensori control awak adult mous pave way understand breath coordin complex non ventilatori behaviour
D006935;D002245
T033;T123;T197
36,300,895
use sleep beauti sb transposon generat stabl cell produc envelop virus like particl evlp pseudotyp sar cov protein vaccin sleep beauti sb transposon system effici non viral tool gene transfer varieti cell includ human cell cut past mechan favorit gene yfg integr rich region within genom provid stabl long term express transfect gene sb system evolv becom power tool gene therapi safeti concern use system handl easi time requir obtain stabl cell line signific reduc compar system current avail present novel applic system generat within day stabl produc hekt cell line capabl constitut deliv envelop virus like particl evlp vaccin provid step step protocol generat sb transposon construct transfect procedur valid produc evlp next describ method pseudotyp constitut produc evlp use spike protein deriv sar cov virus coat evlp capsid heterolog antigen also describ optim method scale product pseudotyp evlp laboratori set g mg publish articl us govern work public domain usa basic protocol generat sb plasmid basic protocol generat stabl hekt cell line constitut secret mlv base evlp basic protocol evalu sb construct immunofluoresc assay basic protocol valid evlp denatur page western blot altern protocol analysi sar cov spike protein oligomer use blue nativ gel electrophoresi western blot altern protocol evalu evlp qualiti electron microscopi negat stain basic protocol small scale product evlp altern protocol larg scale product evlp mg vlps altern protocol larg scale product evlp mg vlps support protocol quantif total protein concentr bradford assay
D064370;D000086382
T123;T047;T116;T067
36,300,844
enzymat product low molecular weight hyaluronan oligosaccharid review prospect hyaluron acid ha nonsulf linear glycosaminoglycan negat charg differ high molecular weight low molecular weight lmw kda hyaluronan oligosaccharid kda exhibit certain uniqu biolog properti owe wide rang applic field medicin howev chemic synthesi high puriti lmw requir complex procedur render process difficult achiev degrad ha achiev catalysi hyaluronidas recent year various hyaluronidas gene identifi enzymat properti analyz context present review summar hyaluronidas differ sourc character review focus crystal structur catalyt mechan under biolog properti hyaluronidas addit molecular weight distribut prepar approach enzymat product lmw describ general orient research hyaluronidas specul base exist literatur accord effici larg scale product lmw use green enzymat approach anticip
D006820;D006821
T123;T121;T116;T109;T126;T122
36,300,841
ginsenosid rc modul sirt nrf interact allevi alcohol liver diseas alcohol liver diseas ald serious worldwid health problem ginsenosid rc major activ ingredi isol panax ginseng whose pharmacolog effect counteract oxid stress inflamm lipid accumul howev still unclear whether ginsenosid rc might exert benefici effect alcohol induc liver injuri aim mice primari hepatocyt mphs challeng alcohol test ginsenosid rc effect intracellular alcohol metabol cblj mice sirt alb mice chronic fed diet ad alcohol given singl gavag alcohol without ginsenosid rc analys alcohol metabol oxid stress inflamm lipid metabol rnaseq express conduct explor potenti target exploit ginsenosid rc protect ald result show ginsenosid rc attenu alcohol induc liver injuri regul oxid stress inflamm lipid accumul vivo vitro ginsenosid rc increas deacetylas activ sirt therebi lower acetyl nrf level elev nrf stabil subsequ exert antioxid effect keep hepat knockout sirt almost abolish hepatoprotect effect ginsenosid rc ald therefor result suggest ginsenosid rc attenu hepatocyt damag oxid stress ald regul sirtnrf pathway henc ginsenosid rc may promis drug treat reliev ald
D056487;D008108;D036145;D037761
T121;T116;T109;T126;T047
36,300,829
fragment optim revers bind switch ii pocket kras lead potent vivo activ kras gc inhibitor activ mutat kras frequent oncogen alter cancer oncogen hotspot posit locat lip switch ii pocket offer coval attach point kras gc inhibitor date kras gc inhibitor discov first coval bind cystein posit optim pocket bind report discoveri vivo activ kras gc inhibitor bi use differ approach small molecul bind revers switch ii pocket identifi optim non coval bind use structur base design final michael acceptor contain warhead attach approach offer altern approach discov kras gc inhibitor also provid start point discoveri inhibitor oncogen kras mutant
D016283;D009369
T191;T126;T116
36,300,825
photodynam versus white light guid resect first diagnosi non muscl invas bladder cancer photo rct around peopl diagnos non muscl invas bladder cancer uk annual recurr follow transurethr resect bladder tumour common intens monitor schedul requir initi treatment associ cost patient nhs photodynam diagnosi transurethr resect bladder tumour photosensitis preferenti absorb tumour cell instil intraves transurethr resect bladder tumour conduct blue light caus photosensitis fluoresc photodynam diagnosi guid transurethr resect bladder tumour offer better diagnost accuraci standard white light guid transurethr resect bladder tumour potenti reduc chanc subsequ recurr
D001749
T191
36,300,823
systemat identif atom center symmetri function develop neural network potenti neural network potenti emerg promis classic forc field enabl long time larg length scale simul close ab initio accuraci learn under potenti energi surfac map cartesian coordin atom system energi use element neural network ensur invari respect system translat rotat atom index permut behler parrinnello type neural network potenti bp nnp cartesian coordin atom transform structur fingerprint use atom center symmetri function acsf develop accur bp nnp chemic system critic reli choic acsf work propos systemat framework identif optim set acsf target system consid divers atom environ present train dataset also inter acsf correl method applic differ kind acsf across divers chemic system demonstr build accur bp nnps water cu system
D016571;D014867
T121;T197;T170
36,300,820
natur histori coronari arteri diseas longitudin nationwid serial angiographi studi background long term cours coronari atherosclerosi studi larg nationwid cohort understand natur histori coronari atherosclerosi could help identifi patient risk futur coronari event method result coronari arteri segment lumin stenosi patient first time coronari angiogram identifi n coronari arteri segment patient follow clinic indic angiographi within year perform death end follow april use scaar swedish coronari angiographi angioplasti registri stenosi progress incid rate ci per segment year respect greatest progress rate occur proxim middl segment left anterior descend arteri male sex diabet associ fold increas risk near new stenos occur patient baselin singl vessel diseas hazard ratio ci coronari arteri segment patient baselin risk factor progress rate incid rate ci increas ci per segment year respect patient risk factor prognost impact risk factor stenosi progress greatest younger patient women conclus coronari atherosclerosi progress slowli frequent left coronari arteri men presenc tradit risk factor coronari arteri segment patient without risk factor littl risk stenosi progress relat impact risk factor appear greater import younger patient women find help understand long term cours coronari atherosclerosi
D003324
T047
36,300,819
predict solvent effect n reaction rate comparison qmmm implicit mm explicit solvent model solvent one key variabl optim synthesi yield properti synthesi product paper contemporari solvent model appli predict rate n reaction rang aqueous non aqueous solvent high level ccsd cbsm x g gas phase energi combin solvat free energi smd sm adf cosmo rs continuum solvent model well molecular mechan mm explicit solvent model differ atom charg scheme predict rate constant three n reaction eight protic aprot solvent reveal predict rate constant organ solvent necessarili less challeng water popular solvent model struggl predict rate constant within log unit experiment valu among continuum solvent model adf cosmo rs model perform best predict absolut rate contant sm model best predict relat rate constant averag accuraci log unit respect use comput demand mm explicit solvent model translat improv absolut rate constant quit effect predict relat rate constant due systemat error cancel free energi barrier obtain umbrella sampl explicit solvent qmmm simul led excel agreement experiment valu provid valid level theori use treat qm region
D056004
T066;T044
36,300,796
non invas prenat test nipt need nation programm aim provis non invas prenat test nipt blood test screen aneuploidi pregnanc vari wide intern ireland nipt avail privat cost gobal research patient perspect nipt show strong desir test provid free attitud toward nipt amongst pregnant women ireland previous studi assess women attend matern servic unit method cross section observ studi involv telephon survey women ask prior knowledg nipt women prior knowledg given inform nipt ask opinion test result one hundr twelv n women particip n heard nipt n believ freeli avail n said would avail test free cost main prohibit factor choos test women wish inform nipt conclus awar nipt amongst women attend matern servic ireland may low desir inform equit provis test
D011296;D004314
T060;T047
36,300,787
hiv skew sar cov b cell respons toward extrafollicular matur pathway hiv infect dysregul b cell compart affect memori b cell format antibodi respons infect vaccin understand b cell respons sar cov peopl live hiv plwh may explain increas morbid reduc vaccin efficaci reduc clearanc intra host evolut sar cov observ hiv coinfect
D000086382;D015658
T047;T067
36,300,786
vitro vascular hydrogel base tissu construct via combin approach cell sheet engin dynam perfus cell cultur bioengin artifici tissu construct requir special attent fast vascular provid cell suffici nutrient oxygen address challeng vitro vascular employ combin approach cell sheet engin print cellular self organ dynam matur cultur confluent cell sheet human umbil vein endotheli cell huvec detach thermorespons cell cultur substrat transfer onto print perfus tubular scaffold use custom made cell sheet roll devic indirect co cultur condit human dermal fibroblast hdfs cell sheet cover vessel mimic embed collagen gel togeth addit singular huvec start sprout surround gel suspend cell around tube self organ form dens lumen contain vascular network throughout gel hdfs cultur huvec contain cell cultur insert provid angiogen support huvec via molecular crosstalk without compet space huvec induc rapid collagen matrix remodel result vascular network remain viabl condit throughout week cell cultur period static indirect co cultur setup transfer dynam flow condit medium perfus enabl via two independ address perfus circuit equip two differ cell cultur chamber one host hdfs host huvec laden collagen gel use system success connect collagen embed huvec cultur dynam medium flow within week dynam cell cultur detect angiogen sprout dens microvascular network format via huvec self organ hydrogel approach combin print cell sheet cover vascular precursor retain sprout capac togeth self assembl huvec dynam perfus cultur result vascular like network critic step toward long term vascular bioengin vitro tissu construct
D020100;D023822
T061;T122
36,300,768
tuber sclerosi rare diseas orphan complex introduct republ ireland tuber sclerosi complex tsc specialist clinic method clinic audit carri assess care receiv patient attend two specialist adult epilepsi specialist centr measur care uk guidelin result although mani baselin investig carri one third patient diagnost genet test result avail neuropsychiatri larg neglect complet neuropsychiatr assess checklist inadequ discuss concern sudep happen access treatment limit report radiolog find tsc inconsist number adult tsc access specialist epilepsi servic appear low discuss tsc care republ ireland fragment difficult navig wast resourc due complex natur diseas formal clinic set manag servic gap echo demand improv care system includ consist radiolog report tsc patholog absenc specialist tsc clinic compound complex navig care individu tsc famili healthcar profession extend audit nation give complet pictur highlight resourc requir bring care patient line recommend guidelin
D014402;D004827
T033;T047;T191
36,300,766
isopod parasit influenc prawn respons activ bopyrid isopod parasit crustacean settl branchial chamber decapod crustacean feed host haemolymph report result experi common prawn palaemon serratus parasit bopyrus squillarum infect uninfect prawn stimul poke plastic rod escap respons trigger number poke record indic prawn respons wherea time spent move follow stimul use indic prawn activ result show bopyrid infect affect prawn respons activ infect prawn requir poke move move less time compar uninfect prawn natur behaviour chang may impact defenc mechan surviv infect prawn could contribut decreas p serratus abund therebi affect coastal ecosystem home speci fisheri reliant irish shrimp fisheri
D033321;D010271;D033364;D033541
T204
36,300,765
infest wild bay scallop argopecten irradian nantucket island shell bore polychaet polydora neocaeca shell bore polychaet worm sever impact shellfish aquacultur reduc growth rate compromis tissu qualiti molluscan host studi report first known instanc shell infest commerci import scallop nantucket island cryptogen polydorid polydora neocaeca addit analys indic high level genet connect worm nantucket island us mainland form distinct haploclad genet isol popul south africa japan transport infect seed could introduc worm nantucket limit sampl pauciti sequenc data avail make imposs definit determin origin
D049897;D011077
T204
36,300,764
develop multiplex qpcr quantif three protozoan parasit eastern oyster crassostrea virginica multiplex quantit pcr qpcr assay simultan detect eastern oyster crassostrea virginica parasit perkinsus marinus haplosporidium nelsoni h costal develop use differ fluoresc label hydrolysi probe primer probe previous valid singleplex qpcr p marinus detect combin newli design primer probe specif h nelsoni h costal function multiplex assay demonstr differ platform linear relationship standard curv similar cycl threshold ct valu parasit effici multiplex qpcr assay roch biorad platform rang sensit detect rang copi plasmid dna p marinus haplosporidium spp respect concord roch biorad platform identif parasit p marinus h nelsoni h costal respect fold increas sensit detect haplosporidium spp biorad thermocycl concord multiplex qpcr histolog p marinus h nelsoni h costal respect discord detect method larg relat local low level infect oyster tissu qpcr sensit diagnost multiplex qpcr develop sensit diagnost tool quantif surveil singl mix infect eastern oyster
D049896;D010271;D041602;D010125
T204
36,300,755
effect covid day mortal rate amongst fragil hip fractur patient aim fragil hip fractur patient alway vulner high rate short term mortal issu may exacerb ongo covid pandem date publish data regard irish hip fractur patient era covid limit studi aim assess effect covid day mortal rate amongst group irish hip fractur patient addit patient demograph length stay admiss haematolog paramet fractur type surgic procedur assess method multicentr observ retrospect studi hip fractur patient n admit six dublin teach hospit covid pandem th februari th juli perform compar purpos equival data retrospect collect relat hip fractur patient admit six teach hospit time period result patient admit specifi timefram compar mean patient age year patient femal statist signific overal differ day mortal rate studi control group p insignific decreas mean length stay day vs day p advanc age p male gender p low admiss haemoglobin p high admiss white cell count p associ increas day mortal conclus found signific differ day mortal rate amongst cohort hip fractur patient height covid pandem ireland advanc age male gender anaemia admiss leucocytosi admiss associ increas day mortal continu covid relat safeti protocol treatment hip fractur patient essenti maintain safe hip fractur servic
D000086382;D006620
T047;T037;T067
36,300,751
applic puls radiofrequ suprascapular nerv provid addit benefit patient undergon glenohumer intra articular steroid inject suprascapular nerv block shoulder pain one common musculoskelet pain syndrom intervent treatment appli patient respond conserv therapi intra articular steroid inject suprascapular nerv block short act may sometim clinic inadequ studi answer question whether puls radiofrequ applic suprascapular nerv provid addit benefit investig
D009407;D061208
T061
36,300,749
preliminari valid turkish version pain catastroph scale children parent pcs c pcs p primari childhood headach aim studi translat pain catastroph scale children parent pcs c pcs p turkish turpc c turpc p evalu psychometr properti children primari headach
D011788;D058443
T078;T033;T041
36,300,748
develop nurs student attitud scale toward pain assess studi aim develop nurs student attitud scale toward pain assess establish valid reliabl
D013338
T097
36,300,747
quantit sensori test find cervic radicular pain relationship symptom studi aim defin compar sensori phenotyp cervic radiculopathi patient exhibit neuropath pain np compon healthi volunt use clinic examin quantit sensori test qst find anoth aim studi show whether symptomat compon pain detect questionnair pdq correl qst find may help clinician indic patient sensori abnorm without use special test
D011843;D009437
T184;T047;T037
36,300,746
evalu effect durat peripher block appli high concentr local anesthet steroid trigemin neuralgia aim studi investig effect durat peripher block appli high concentr local anesthet steroid trigemin neuralgia
D014277
T047
36,300,745
spread anesthet peripher block neck shoulder junction accord local clavicl case seri brachial plexus block local anesthet diffus clavicl spread epidur space cephal tendenc aim show local anesthet spread accord integr clavicl ad contrast agent peripher block observ barrier creat clavicl neck shoulder junction disappear fractur cm drug distribut show caudal transit think type degre clavicl fractur chang drug diffus affect success block
D001917;D065527
T061;T023
36,300,744
investig level low back pain depress burnout personnel provid formal care children disabl elder individu aim studi investig compar low back pain depress burnout level among formal caregiv elder individu children disabl
D019988;D017116;D002055
T184;T047;T101;T048
36,300,743
investig antinocicept effect vitamin eb rat aim studi investig effect vitamin pain threshold rat addit examin whether eb vitamin receptor agonist contribut mechan increas effect receptor
D018167;D014807
T121;T116;T127;T192
36,300,742
superior cluneal nerv entrap neuropathi due lower cross syndrom case low back pain superior cluneal nerv scn sensori nerv known origin dorsal rami lower thorac lumbar nerv root one overlook caus low back pain lbp scn entrap neuropathi scnen scnen may also associ scn stretch due lumbar movement poor bodi postur increas paravertebr muscl tonus year old femal patient present chronic lbp local right iliac crest radiat right buttock groin leg increas lumbar lordosi anterior pelvic tilt tender point right iliac crest pain radiat buttock posterolater thigh tinel sign diagnos lower cross syndrom scnen therapeut nerv block perform clinician consid scnen possibl diagnosi lbp
D017116;D009408;D009407;D000015
T061;T184;T047;T019
36,300,741
frequenc relat factor primari headach patient hashimoto thyroid purpos studi evalu incid primari headach potenti biomark patient diagnos hashimoto thyroid
D050031;D008881
T047
36,300,740
evalu musculoskelet pain relat factor school age children year aim studi evalu frequenc pain relat factor musculoskelet system children
D059352
T033
36,300,739
spinal cord stimul treatment ischem pain burger diseas raynaud diseas report two case literatur review ischem pain main symptom group diseas result inadequ blood flow extrem ischemia symptomatolog two major diseas distinguish critic vascular diseas raynaud phenomenon critic vascular diseas background atherosclerosi caus diabet mellitus hypertens raynaud phenomenon divid primari secondari form primari form due vasospasm under caus secondari form associ under connect tissu rheumat diseas peripher vascular diseas thromboang obliteran burger diseas clinic find raynaud diseas vasomotor chang cold exposur bruis cold pain paresthesia ulcer due chronic ischemia clinic present critic ischem diseas intermitt claudic earlier stage rest pain gangren necrosi trophic chang ad advanc stage treatment raynaud diseas earli stage medic conserv case advanc stage ischem vascular diseas medic treatment resist pain insuffici respons endovascular treatment inoperabl case intervent sympathectomi spinal cord stimul scs applic scs reduc vascular resist vasodil mediat increas blood flow scs also suppress sympathet vasoconstrict increas tissu vascular reduc tissu damag provid ulcer heal pain reduct report demonstr persist raynaud diseas advanc stage burger diseas success treat scs
D011928
T047
36,300,733
sar cov test patient wait time emerg depart aim emerg depart ed impact earli coronavirus diseas covid pandem high attend number ed reli upon sar cov revers transcriptas polymeras chain reaction rt pcr test triag patient facilit admiss appropri ward mean posit patient isol earli possibl octob introduc hour sar cov test servic examin impact patient experi time pet ed healthcar associ ha covid infect method data pet introduct hour test avail ed ha covid infect report week health servic execut key perform indic result mean pet prior pandem hour drop hour respect first second wave surg case number ed attend third wave reflect rise pet mean pet hour signific pre pandem level ha covid infect remain stabl wave one three v conclus introduct hour sar cov test ed contribut reduct pet facilit appropri patient placement ward level kept ha covid infect accept low level
D000086402;D000086382
T005;T067;T047
36,300,707
implement medic student teach gynaecolog healthcar transgend patient introduct transgend peopl specif healthcar need experi difficulti access health servic medic student receiv teach general gynaecolog healthcar issu popul aim assess medic student knowledg healthcar need transgend peopl newli implement teach session transgend healthcar method mix method studi carri three month period univers obstetr gynaecolog hospit dublin one hour teach session develop deliv final year medic student student complet survey receiv lectur result seventi one student complet pre lectur survey forti three complet post lectur survey pre lectur student report understand healthcar issu transgend peopl report understand gynaecolog issu face transgend peopl post lectur better understand health issu face popul better understand gynaecolog health issu face student want teach topic conclus one hour teach session effect improv student knowledg care transgend peopl teach could expand irish medic school go forward teach could adapt post graduat obstetr gynaecolog teach
D063106;D013337;D006176
T098;T091;T097
36,300,706
nation audit criteria pre oper sickl cell screen children aim set identifi current practic anaesthesiolog depart ireland public hospit deliv paediatr anaesthesia regard pre oper screen sickl cell diseas scd sickl cell trait sct method depart anaesthesiolog public hse fund hospit deliv paediatr anaesthesia contact three month period exist polici regard pre oper screen paediatr patient sickl cell diseas trait sought comparison made screen polici place result respons receiv hospit three anaesthesiolog depart formal polici place ethnic identifi pre oper screen vari across three hospit conclus despit signific increas number peopl african middl eastern amp indian descent live ireland recent year neonat screen programm sickl cell exist nation polici exist criteria guid practic pre oper screen patient scdsct trait survey highlight lack standardis approach pre oper sickl cell screen children across ireland public hospit system view increas multicultur ireland recommend nation review merit introduct develop target nation guidelin pre oper screen sickl cell risk children
D012805;D000755
T047
36,300,689
safe manag pop eat disord team background anorexia nervosa high mortal complic risk nourish nourish care compromis behaviour issu method retrospect studi ten patient eat disord admit sligo univers hospit treat pop demand multidisciplinari eat disord team result femal mean bmi admiss kgm discharg kgm p signific lower initi measur may repres water load bowel retent admiss biochemistri normal nine subject six subject experienc refeed syndrom one hypoglycaem mmoll set aspir pneumonia five exhibit treatment avoid behaviour includ food cach micro exercis mean length stay day posit correl weight gain admiss p month follow bmi higher admiss eight subject two voluntarili withdrew follow conclus high incid treatment avoid behaviour initi weight mislead high admiss biochemistri mislead normal hypoglycaemia associ infect incid refeed syndrom high notwithstand patient manag safe effect general hospit coordin well structur approach multidisciplinari team
D055677;D000856;D001068
T047;T048
36,300,667
central nervous system action leptin improv cardiac function ischemia reperfus role sympathet innerv sex differ background therapeut strategi prevent paradox reperfus injuri myocardi ischemia limit test whether central nervous system action leptin induc import protect effect cardiac function metabol myocardi ischemiareperfus ir injuri role cardiac sympathet innerv mediat effect whether major sex differ cardioprotect effect chronic central nervous system leptin infus method result myocardi ir induc temporari ligat left descend coronari arteri male femal wistar rat instrument intracerebroventricular cannula later ventricl vehicl leptin gh infus start immedi reperfus continu day use osmot minipump connect intracerebroventricular cannula cardiac function assess echocardiographi ventricular pressur exercis perform intracerebroventricular leptin treatment mark attenu cardiac dysfunct post ir evidenc improv eject fraction versus maxim rate left ventricl rise versus mm hg exercis perform versus compar vehicl treat rat intracerebroventricular leptin infus reduc infarct size femal male compar ad lib fed pair fed salin treat rat intracerebroventricular leptin treatment also increas cardiac nad nadh content fold improv mitochondri function compar vehicl treatment cervic ganglia denerv attenu cardiac protect effect leptin ir injuri conclus data indic leptin via central nervous system action mark improv overal heart function mitochondri metabol ir injuri regardless sex effect larg independ cardiac sympathet innerv
D015428;D017202
T047;T046
36,300,665
atherosclerosi potenti caus deep embol stroke undetermin sourc high resolut magnet reson imag studi background potenti caus sourc embol stroke undetermin sourc esus vari studi aim investig main caus deep esus evalu nonstenot intracrani atherosclerot plaqu method result retrospect screen consecut patient unilater anterior circul esus exclud patient possibl embol extracrani arteri aortic arch plaqu carotid plaqu enrol patient esus categor group deep esus cortic withwithout deep esus patient underw intracrani high resolut magnet reson imag assess characterist nonstenot intracrani atherosclerot plaqu biomark atrial cardiopathi ie p wave termin forc lead v ecg nt probnp n termin pro brain natriuret peptid left atrial diamet collect total patient ipsilater nonstenot intracrani atherosclerot plaqu found deep esus cortic withwithout deep esus found preval plaqu segment middl cerebr arteri ostia perfor smaller remodel index plaqu burden less frequent occurr complic plaqu deep esus versus cortic withwithout deep esus higher bnp brain natriuret peptid level higher preval atrial cardiopathi cortic withwithout deep esus versus deep esus moreov discrimin vulner plaqu predict esus signific enhanc adjust exclud patient deep esus conclus current studi provid first high resolut magnet reson imag evid cortic withwithout deep esus deep esus distinct entiti atherosclerosi embol might main caus deep esus
D020766;D000083262;D020521;D058226;D004617;D050197;D006331;D002537
T020;T033;T047;T046;T031
36,300,664
trend predictor outcom cardiovascular complic deliveri associ gestat diabet nation inpati sampl analysi background gestat diabet gd associ increas risk long term cardiovascular complic howev data acut peripartum cardiovascular complic well establish henc aim investig associ gd acut cardiovascular outcom time deliveri admiss method result use data nation inpati sampl intern classif diseas ninth revis icd tenth revis icd code use identifi deliveri hospit gd diagnosi total weight hospit deliveri identifi among individu gd n preval gd obes increas studi period p trend individu gd versus without gd higher preval obes hypertens dyslipidemia adjust age race ethnic comorbid insur incom gd remain independ associ cardiovascular complic includ preeclampsia adjust odd ratio aor ci peripartum cardiomyopathi aor acut kidney injuri aor stroke aor arrhythmia aor compar gd moreov deliveri hospit among individu gd associ increas length versus day p cost hospit versus p even absenc preeclampsia gd associ elev cardiovascular risk conclus individu gd higher risk preeclampsia peripartum cardiomyopathi acut kidney injuri stroke arrhythmia deliveri hospit rate gd increas global effort improv preconcept cardiometabol health prevent gd may repres import strategi improv peripartum matern outcom mitig long term cardiovascular risk
D016640;D011225;D009202;D011644;D020521;D058186
T047;T046;T037
36,300,662
real time magnet reson imag studi orthostat intoler mechan human be proof concept background discern mechan drive orthostat symptom human be remain challeng therefor develop novel approach combin cardiac cerebr real time magnet reson imag beat beat physiolog monitor orthostat stress test lower bodi negat pressur lbnp conduct proof concept studi patient sever orthostat hypotens method result includ year old man pure autonom failur without mmhg lbnp obtain real time magnet reson imag cardiac short axi quantit flow measur pulmonari trunk middl cerebr arteri blood pressur mmhg supin rest mmhg lbnp lbnp left ventricular stroke volum decreas absolut middl cerebr arteri flow pulmonari trunk flow conclus combin real time magnet reson imag lbnp continu blood pressur monitor provid promis new approach studi orthostat intoler mechan human be
D054971
T033
36,300,661
integr complementari practic control nausea vomit pregnant women systemat review synthes evid avail literatur effect integr complementari practic nausea vomit treatment pregnant women
D000932;D009822
T121;T039;T109
36,300,658
dysregul gene microrna biolog pathway gastrocnemius muscl fiber type associ progress peripher arteri diseas preliminari analysi background peripher arteri diseas pad associ gastrocnemius muscl abnorm howev biolog pathway associ gastrocnemius muscl dysfunct associ progress pad larg unknown studi character differenti gene microrna mirna express gastrocnemius biopsi peopl without pad compar pad particip pad includ without pad progress method result mrna mirna sequenc perform identifi differenti express gene differenti express mirna mrna mirna interact associ biolog pathway set comparison pad progress n versus non pad n pad progress n versus non pad pad progress versus pad progress immunohistochemistri perform determin gastrocnemius muscl fiber type muscl fiber size differenti express gene differenti express mirna abund comparison pad progress versus non pad compar pad versus without progress among top signific cellular pathway subject pad progress muscl contract develop transform growth factor beta growthdifferenti factor activin signal inflamm cellular senesc notch signal subject pad progress increas frequenc smaller type gastrocnemius muscl fiber exploratori analys conclus human pad progress exhibit greater differ number gene mirna express biolog pathway type muscl fiber size compar without pad fewer differ observ peopl pad without progress control patient without pad studi need confirm whether identifi transcript may serv potenti biomark diagnosi progress pad
D035683;D058729
T123;T047;T114
36,300,657
social isol implement advanc care plan among hospit patient heart failur background implement advanc care plan acp heart failur manag insuffici social isol si could barrier acp initi albeit relationship si patient prefer acp end life care remain unknown method result conduct questionnair survey includ assess si use item lubben social network scale well patient perspect acp end life care patient approach multidisciplinari heart failur team admiss patient complet survey median age year men cox proport hazard model construct elucid short term day prognost impact si overal particip high risk si item lubben social network scale score high risk patient negat attitud toward acp without versus p actual perform acp convers patient without high risk respect regard prefer end life care say one want tell love one versus p spend enough time famili versus p less import high risk patient high risk si associ higher day risk adjust caus mortal hazard ratio ci conclus hospit patient heart failur high risk si frequent observ high risk patient associ negat attitud toward acp despit higher mortal research requir establish ideal approach provid acp social vulner patient
D032722;D013727;D006333
T058;T046;T047
36,300,637
expans genet code reassign redund sens codon use fulli modifi trna break codon degeneraci introduct non canon amino acid offer mani opportun synthet biolog yet despit exist codon code expand amino acid vitro limit factor could relianc synthet trnas lack post transcript modif improv translat fidel determin whether modifi wild type trna could improv sens codon reassign develop new fluorous method trna captur appli isol rough half escherichia coli trna isoacceptor perform codon competit experi five captur wild type leucyl trnas synthet counterpart reveal strong prefer wild type trna vitro translat system final compar abil wild type synthet leucyl trna break degeneraci leucin codon box show captur wild type trnas discrimin enough fidel accur split leucin codon box encod three separ amino acid wild type trnas therefor enabl reagent maxim reassign potenti genet code
D005815;D012343
T123;T085;T114
36,300,627
cryptic transactiv domain ezh bind ar ar splice variant promot oncogen activ tumor transform enhanc zest homolog ezh androgen receptor ar crucial chromatingen regul involv develop andor progress prostat cancer includ advanc castrat resist prostat cancer crpc sustain prostat tumorigen ezh establish non canon biochem interact ar mediat oncogen activ addit canon role transcript repressor enzymat subunit polycomb repress complex prc howev molecular basi under non canon activ ezh prostat cancer remain elus therapeut strategi target ezh ar mediat oncogen activ also lack report cryptic transactiv domain ezh ezhtad bind ar ar splice variant ar v constitut activ ar variant enrich crpc mediat assembl andor recruit transactiv relat machineri genom site lack prc bind non canon target ezh arar v co activ enrich clinic relev oncogen also show ezhtad requir chromatin recruit ezh oncogen ezh mediat oncogen activ crpc growth vitro vivo complet block ezh multifacet oncogen activ prostat cancer employ ms recent develop proteolysi target chimera protac ezh strike ms achiev target deplet ezh canon ezh prc non canon ezhtad arar v co activ complex prostat cancer cell elicit far potent antitumor effect catalyt inhibitor ezh overal studi report previous unappreci requir ezhtad mediat ezh non canon co activ recruit gene activ function prostat cancer suggest ezh target protac potenti attract therapeut treatment aggress prostat cancer reli circuit wire ezh ar
D000071221;D064129;D011944
T191;T126;T116;T192
36,300,626
structur basi hflxr mediat antibiot resist listeria monocytogen hflx ubiquit bacteri gtpase split recycl stress ribosom addit hflx listeria monocytogen contain second hflx homolog hflxr unlik hflx hflxr confer resist macrolid lincosamid antibiot experiment unexplor mechan determin cryo em structur l monocytogen hflxr hflx complex well l monocytogen ribosom presenc absenc lincosamid lincomycin overal geometri hflxr subunit similar hflx loop within n termin domain hflxr two amino acid longer hflx reach deeper peptidyltransferas center moreov unlik hflx bind hflxr induc conform chang within adjac rrna nucleotid would incompat drug bind find suggest hflxr confer resist use alloster ribosom protect mechan rather simpli split recycl antibiot stall ribosom
D008089
T007
36,300,625
structur function determin archaeal oxoguanin dna glycosylas agog dna damag recognit process oxoguanin go major purin oxid product dna high mutagen properti go absolut must elimin dna aerob anaerob organ three kingdom life evolv repair mechan prevent deleteri effect genet integr major way remov go base excis repair pathway usual initi go dna glycosylas first identifi bacteria fpg eukaryot ogg go dna glycosylas recent identifi archaea ogg agog agog less document enzym mode damag recognit remov remain clarifi molecular atom level studi present complet structur characteris apo agog pyrococcus abyssi pab thermococcus gammatoleran tga first structur pab agog bound lesion contain singl doubl strand dna combin x ray structur analysi site direct mutagenesi biochemistri experi identifi key amino acid residu agog respons specif recognit lesion base opposit lesion catalysi moreov uniqu bind mode go involv doubl base flip never observ dna glycosylas reveal addit unravel properti agog studi compar biochem structur analysi offer new insight evolutionari plastic dna glycosylas across three kingdom life
D045647;D019712
T194;T126;T116
36,300,594
placenta accreta spectrum year retrospect observ studi aim assess manag outcom placenta accreta spectrum disord highlight import manag recommend intern guidelin method retrospect audit women diagnos placenta accreta spectrum disord januari decemb result nine case placenta accreta birth identifi women receiv caesarean section general anaesthesia caesarean hysterectomi occur seven case mean sd age women year mean pariti score mean gestat age birth week bilater iliac arteri balloon occlus occur eight case median estim blood loss rang ml patient experienc l blood loss intraop red blood cell transfus occur six case median number unit red cell transfus rang four unit mean hospit length stay day matern death multidisciplinari team involv senior anaesthetist obstetrician note case discuss placenta accreta spectrum increas incid obstetr practic associ signific matern morbid mortal implement nation guidelin improv patient outcom
D010921;D006473
T046
36,300,566
identif colorect cancer use structur free text clinic data colorect cancer incid continu fallen among year old howev incid increas even recent screen guidelin recommend screen begin age near half earli onset colorect cancer miss method need identifi high risk individu age group target screen colorect cancer studi clinic studi requir labor intens chart review identif affect risk factor natur languag process machin learn use autom process enabl screen larg number patient studi develop compar four machin learn statist model logist regress support vector machin random forest deep neural network perform classifi colorect cancer patient excel classif perform achiev auc
D000069550;D015179
T191;T066
36,300,558
radial nerv entrap fractur supracondylar humerus rare case year old supracondylar fractur humerus one common fractur seen children posteromedi displac distal fragment extens type supracondylar humerus fractur caus injuri radial nerv year old girl present symptom radial nerv injuri supracondylar fractur right humerus complet posteromedi displac distal fragment gartland type iii underw surgeri close reduct percutan pin perform patient routin follow month postop neurolog improv seen exploratori surgeri reveal complet discontinu radial nerv fractur site entrap nerv stump heal bone callus gap cm observ nerv stump sural nerv cabl graft perform good result neurolog symptom improv time appropri differenti diagnosi necessari exploratori surgeri consid despit limit report conflict outcom sural nerv cabl graft could use option bridg gap discontinu nerv injuri level evid level iv case report
D020425;D006810;D005594
T033;T047;T037;T061
36,300,557
bilater bi level erector spina plane block scoliosi surgeri retrospect compar studi studi aim compar effect ultrasound us guid erector spina plane block espb pain score opioid requir patient satisfact length hospit stay standard analgesia method follow scoliosi surgeri
D009407;D012600
T061;T047
36,300,556
comparison clinic radiograph outcom plate fixat versus new generat lock intramedullari nail manag adult forearm diaphys fractur studi aim compar function radiograph outcom follow intramedullari nail imn versus plate screw osteosynthesi manag patient diaphys forearm fractur
D014458;D011885;D005594;D005543
T061;T037
36,300,535
physic age hydroxypropyl methylcellulos acet succin via enthalpi recoveri amorph solid dispers asd util kinet stabil amorph state stabil drug molecul within glassi polym matrix therefor understand glassi state stabil polym excipi critic asd design perform investig physic age hydroxypropyl methylcellulos acet succin hpmcas common use polym asd formul found hpmcas exhibit convent physic age behavior anneal near glass transit temperatur g scenario structur recoveri facilit relax dynam howev anneal well g sub relax process facilit low temperatur physic age hpmcas nevertheless physic age rate exhibit signific chang k g exhibit near monoton decreas decreas temperatur final infrar spectroscopi employ assess effect physic age chemic structur hpmcas known suscept degrad temperatur k g result provid critic insight necessari understand better link stabil asd physic age glassi polym matrix
D008747;D005079
T120;T121;T109;T122;T130
36,300,520
evolutionari allometri ecolog correl fang length evolut viper trait prey acquisit form phenotyp interfac predat prey interact venom predat morpholog variat venom deliveri apparatus like fang stinger may optim dispatch prey determin singl dimens venom inject system evolv respons variat size climat condit dietari ecolog viperid snake measur fang length museum specimen repres viper speci recogn speci find phylogenet signal within clade variat relat fang length across viper suggest general taxonom trend potenti adapt diverg fang length recov posit evolutionari allometri littl static allometri fang length proport longer fang evolv larger speci may facilit venom inject volumin prey final leverag climat diet data assess global correl fang length find model fang length evolut improv inclus temperatur diet particular extent diet mammal heavi diet find demonstr adapt variat emerg among compon complex prey captur system
D014070;D017819
T014;T023
36,300,518
synthesi novel benzothiophen deriv protector cranial irradi induc neuroinflamm aim cranial irradi result mani deleteri effect normal tissu includ neuroinflamm need explor radioprotect agent could safe use amelior effect method nine novel benzothiophen deriv bear pyrimidinon pyrazolidinon triazol activ moieti synthes evalu antioxid vitro screen experi potent compound test protector radiat induc neuroinflamm oxid stress rat brain follow cranial irradi result potent antioxid compound compound p fluro p bromo pyrido benzothiophen deriv offer good antioxid anti inflammatori effect conclus compound may introduc nontox candid adjuv therapeut protocol use head neck tumor radiotherapeut manag
D000975;D011837
T123;T039;T121;T044
36,300,498
surfac acoust wave driven pumpless flow sperm rheotaxi analysi sperm rheotaxi phenomenon sperm cell swim direct fluid flow one major guid mechan long distanc sperm migrat within femal reproduct tract howev current approach studi pose challeng deal rare sampl continu introduc extra buffer develop devic utilis acoust stream steadi flow driven acoust perturb drive tuneabl well regul continu flow veloc rang correspond maximum shear rate channel interest rang suitabl probe sperm rheotaxi behaviour use devic studi sperm rheotaxi microchannel distinct geometri repres geometr characterist inner surfac fallopian tube identifi sperm dynam presenc flow channel various width found higher later head displac alh suffici motil rheotact sperm channel presenc acoust generat flow well chang migrat direct increas curvilinear veloc vcl suffici motil sperm channel increas averag flow veloc result provid insight understand sperm navig strategi femal reproduct tract rheotact sperm swim near boundari overcom flow femal reproduct tract reach fertil site surfac acoust wave devic present simpl pumpless altern studi microswimm within vitro model enabl discoveri new insight microswimm migrat strategi potenti offer opportun rheotaxi base sperm select flow essenti applic
D013081;D012661
T031;T043
36,300,497
conflict interest scientif advisori panel independ crucial qualiti credibl scientif recommend guidelin composit advisori committe requir full understand relationship interest prospect committe member addit financi relationship intellectu interest profession interest reput may also play role addit prevent conflict interest among committe member precaut also requir review authoris stage draft recommend describ potenti perceiv conflict interest may occur qualiti independ advisori process safeguard
D016265;D026683
T078;T064
36,300,496
regul market failur healthcar qualiti comparison improv competit dutch healthcar market competit healthcar market controversi financi interest may negat influenc patient interest netherland public healthcar qualiti indic publish annual comparison made hospit privat healthcar facil phf oper dutch healthcar market nine indic could compar demonstr overal equival success complic rate known phfs treat healthier patient qualiti care may fact lower howev without casemix inform conclus healthcar qualiti drawn dutch experi regul competit healthcar market lack full transpar inform caus market failur improv implement qualiti comparison use routin collect casemix variabl
D019981;D003695
T078;T058;T169;T093
36,300,494
dutch guidelin prevent periop pulmon complic adher patient histori chronic obstruct pulmonari diseas copd asthma undergo surgeri risk develop postop pulmonari complic associ morbid mortal nation guidelin compos prevent strategi non thorac surgeri periop administr corticosteroid cornerston investig implement hospit
D029424;D001249
T047
36,300,493
guidelin customis integr care multimorbid patient multimorbid healthcar provid follow various diseas specif guidelin besid fact simultan treatment sever chronic diseas intens patient also risk contradictori advic interact recommend appli simultan number develop make guidelin applic grow target group multimorbid patient methodolog senior proof guidelin describ pay attent patient multimorbid phase guidelin develop addit integr guidelin use multimorbid develop new modular structur use interconnect futur doctor acquir knowledg skill translat treatment goal patient multimorbid integr coordin tailor made plan cooper profession guidelin treatment multimorbid provid support work across domain without direct applic evid
D000076322;D019033
T078;T058;T093
36,300,492
toto imag earli enter nervous system develop reveal gut colon tie prolifer downstream ret enter nervous system vast intrins network neuron glia within gastrointestin tract larg deriv enter neural crest cell encc emigr gut vertebr embryon develop studi encc migrat dynam genet regul provid great insight fundament collect cell migrat nervous system format pertin subject studi due relev human congenit diseas hirschsprung diseas hscr first time perform toto gut imag singl cell generat trace encc migrat wild type novel ret heterozyg background zebrafish retwmr gain insight encc dynam vivo observ retwmr zebrafish produc fewer encc local along gut encc fail reach hindgut result hscr like phenotyp specif observ prolifer depend migrat mechan cell divis associ inter cell distanc migrat speed last detect prematur neuron differenti gene express signatur retwmr encc result suggest ret signal may regul mainten stem state encc
D017615;D006627
T022;T047;T019
36,300,491
count abort histor coincid term abort stand undo even earli involuntari concept origin abort unwant miscarriag deriv late nineteenth centuri physician introduc express provok abort age old oper end want pregnanc save woman life henc express unrel even older attempt induc one period herb invok miscarriag woman initi articl summar twentieth centuri develop lead use abort most latter practic unfortun consequ misoprostol creat acquir moral loaden name abort pill yet may well seen long search herb provid sexual activ women safe effici inexpens mean keep one period go regardless eggcel fertil
D000022;D016595;D000028
T061;T121;T109;T093;T033;T081;T047;T046
36,300,490
prehabilit surgeri case concept prehabilit sound logic studi result promis far unequivoc answer question whether prehabilit cost effect therefor posit prehabilit standard care yet agenda achiev multicent research stimul nation coordin research fund order clarifi cost effect prehabilit
D000082622;D011300
T061;T058
36,300,489
assess new oncolog drug number cancer patient increas new most expens treatment option evolv rapid critic evalu valu new treatment requir order maintain access new drug afford cancer care netherland dutch societi medic oncolog ciebom nvmo ciebom uniqu role assess valu use new oncolog drug next nation committe health insur ciebag dutch health care institut ciebom develop transpar criteria approv oncolog drug sever set recent also criteria drug test non randomis studi develop
D008495;D009369
T191;T091
36,300,488
import profession guidelin appropri care appropri care form cornerston integr care agreement compos sign sever dutch health care organ govern profession guidelin play import role fulfil four principl appropri care guidelin contribut valu base care describ effect effici treatment contribut person care basi tool share decis make contribut right care right place cooper coordin across domain contribut health instead sick recommend prevent self care obvious accompani multipl challeng address togeth possibl solut hope result fact guidelin remain essenti appropri care
D000080536
T041
36,300,487
monkeypox new pandem monkeypox mpx diseas caus monkeypox virus viral zoonot diseas endem central west africa human human spread also occur featur current global outbreak far know exponenti transmiss outbreak relat chang viral characterist due multipl high risk contact subset peopl contract virus far almost exclus affect men sex men msm appropri public health measur increas alert health care provid need increas case find decreas transmiss real chanc mpx becom endem larg part world
D045908;D000072339
T047;T098
36,300,486
coupl proton vibrat two weak acid hing complex formic acid trifluoroethanol formic acid trifluoroethanol co expand slit nozzl vacuum singl domin hing like complex form signific amount two oh stretch fundament separ cm unambigu assign combin infrar absorpt raman scatter quantum chemic calcul differ level reproduc find satisfactori way suggest phase raman sensit lower wavenumb oh stretch excit less along concert degener proton transfer coordin hydrogen bond ring stay barrier concert exchang anharmon calcul indic weak intens share dark state come reach due hydrogen bond downshift oh stretch vibrat well behav system set stage acid combin basic alcohol phase oh stretch vibrat difficult detect possibl due fast intra complex vibrat dynam thus provid benchmark point one explor evolut vibrat reson acid proton meet electron rich alcohol oxygen
D014732;D011522
T196;T070
36,300,483
new techniqu inguin hernia repair children laparoscop percutan inguin ring sutur inguin hernia repair one frequent perform oper pediatr popul laparoscop hernia repair current increas perform dutch academ non academ hospit laparoscop pir techniqu invent prof dr patkowski extra corpor techniqu use one trocar camera use subcutan knot sutur compar open techniqu pir techniqu offer possibl contralater inspect without make extra incis case contralater patent processus vaginali cppv offer possibl simultan repair cppv prevent develop metachron contralater inguin hernia mcih one frequent reason oper open inguin hernia repair result less oper less exposur general anesthesia less hospit admiss less visit general practition emerg depart
D006552;D010535
T060;T047;T190;T061
36,300,482
financi conflict interest anti cancer drug ntvg stanc exclud pharma advertis import number new oncolog treatment increas rapid even though mani offer limit benefit patient case scientif research lead approv mar shortcom nonetheless mani drug limit valu approv regulatori agenc one factor contribut thereto financi conflict interest fci pharmaceut industri pharma occur differ level includ research opinion leader editor medic journal fci contribut patient exposur treatment offer limit benefit unjust spend valuabl resourc provid larg revenu pharma import step nederlandstijdschriftvoorgeneeskund ntvg omit pharmaceut advertis well advertis pharmaceut industri sponsor medic educ send import signal first step revalu import relationship pharmaceut industri
D016265;D000970
T078;T121;T109
36,300,481
hypoglycaemia bariatr surgeri benefici effect bariatr surgeri type diabet come price develop postprandi hypoglycaemia also call post bariatr hypoglycaemia pbh pbh extend present almost patient bariatr surgeri sometim lead serious hypoglycaemia
D003924;D015390;D007003;D050110
T061;T047
36,300,479
man cola colour urin year old man refer emerg depart fundashonmariad hospit bonair abnorm color urin exercis heavili laboratori test show rhabdomyolysi creatin kinas level ul hyperhydr creatin kinas valu decreas rapid renal function remain normal
D030221;D012206
T121;T046;T002;T109
36,300,478
prion diseas netherland twenti nine year surveil prion diseas monitor netherland sinc year nation registri coordin erasmus medic center sinc year averag new patient diagnos prion diseas slight increas incid prion diseas probabl due better recognit improv diagnost recent develop diagnost real time quak induc convers rt quic test detect prion protein cerebrospin fluid high sensit specif polymorph codon prion gene prnp determin suscept differ subtyp creutzfeldt jakob diseas cjd influenc clinic cours awar atyp present cjd cjd mimic import autoimmun enceph often treatabl resembl cjd
D007562;D017096;D011328
T047;T005;T116
36,300,477
alarm fatigu continu monitor general ward continu monitor vital sign wearabl wireless sensor increas appli general nurs ward although alarm consid import earli detect clinic deterior alarm fatigu serious hamper implement continu monitor current system regular generat high fals alarm frequenc general unwork moreov potenti yield alarm small acut life threaten event general ward extrem rare articl describ perspect base experi continu monitor surgic ward without use alarm instead trend heart rate respir monitor everi hour allow adequ detect gradual deterior follow studi effect method current conduct center futur research focus develop predict algorithm aid interpret monitor trend data
D056902
T074
36,300,476
atyp present tuberculosi known tb infect netherland accord dutch ministri health rivm locat bone joint incid multi drug resist mdr tb netherland
D009169;D018088;D014376
T047;T007
36,300,475
woman pituitari stone year old femal patient present acut onset nystagmus vertigo magnet reson imag mri perform reveal pituitari stone metabol imbal describ caus endocrinolog analysi show elev correct serum calcium level mmoll nuclear radiolog analysi expos primari hyperparathyroid
D002118;D014717
T123;T121;T184;T196;T033;T047;T046
36,300,474
often medic guidelin refer articl written dutch dutch medic guidelin dutch research articl publish ntvg nederlandstijdschriftvoorgeneeskund medic journal search systemat use sporad use public process guidelin develop use recommend regard dutch context care research investig often part dutch guidelin articl publish ntvg use
D014956;D001065
T090;T023
36,300,473
vulvar lymphangioma circumscriptum diagnosi treatment vulvar form lymphangioma circumscriptumi rare condit part acquir lymphangiectasia aris secondari exampl surgeri radiotherapi malign pelvic region inflamm vulvar lymphedema occur morbus crohn
D014846;D009450;D008202;D014845
T047;T191
36,300,472
deviat guidelin recommend diagnost work general practic exampl involv high sensit troponin crp test clinic guidelin essenti decis make base latest evid encompass given patient context deviat guidelin recommend common practic attribut contextu ethic clinic scientif factor set diagnost test deviat recommend diagnost work may result test clinic lesson discuss two scenario primari care one involv high sensit troponin test patient episod chest discomfort involv crp test pediatr patient acut onset abdomin pain
D014336;D058006
T123;T091;T116
36,300,471
hypoglycaemia patient without diabet mellitus structur approach diagnost process hypoglycemia import find right diagnosi first step recogn symptom hypoglycemia confirm hypoglycemia symptom dissolv complaint glucos level restor normal confirm whippl triad second step exclud common caus third import step diagnost fast test measur insulin c peptid hypoglycemia guid exogen endogen caus hyperinsulin target addit investig requir often under caus treatabl justifi need measur well time serum glucos hypoglycemia suspect make quick diagnosi
D007003;D006946;D003920
T047
36,300,470
experi mri guid brachytherapi radiorecurr prostat cancer mr guid brachytherapi offer focal salvag treatment local recurr case isol local recurr prostat cancer prostat andor semin vesicl primari radiotherapi focus local recurr instead whole prostat chanc addit toxic bladder urethra rectum minim almost patient treatment lead good initi treatment respons persist half patient other develop progress diseas later select suitabl patient factor preexist urinari bowel complaint local size recurr psa doubl time time primari radiotherapi develop recurr relev mr guid brachytherapi provid suitabl salvag strategi aim defer androgen depriv therapi chanc cure
D001918;D011471
T061;T191
36,300,469
guidelin histor perspect role clinic practic guidelin chang dramat past year benefici also disadvantag effect consid intern develop grow bodi evid evolv methodolog limit might reach alreadi reach solut thereof part nation part intern intern new methodolog technolog use artifici intellig nation coher approach coher medic disciplin also polici govern regul health insur call renew integr encompass vision
D001185;D007343
T090;T092;T073;T066