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biomedical-topic-categorization-validation

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36,301,418
apoptot process preced infect symbiont pogonophoran lavra siboglinida annelida fine structur bodi wall gut first time studi compet larva frenul pogonophoran siboglinum fiordicum mass apoptosi cell nuclei observ dermo muscular bodi wall coelom epithelium apoptot nuclei found cell cytoplasm outsid larval bodi latter case nucleus surround plasmalemma entir cluster cover cuticl cell larval gut retain usual structur cytoplasm fill numer yolki granul nucleus display usual morpholog similar apoptot process describ vestimentiferan found initi penetr symbiot bacteria integu dorsal mesenteri process apoptot rearrang bodi wall cell format uniqu symbiosi bacteria assum time space fiordicum occur sequenti rather simultan unlik vestimentiferan
D000845;D011077
T204
36,301,417
earli pleistocen horsesho bat rhinolophus macrorhinus cimmerius subsp nov rhinolophida chiroptera taurida cave crimea numer remain incomplet skull cranial mandibular fragment isol teeth larg horsesho bat rhinolophus ferrumequinum group describ lower pleistocen depo sit taurida cave central crimea assign rhinolophus macrorhinus cimmerius subsp nov dental charact new subspeci less special r anomaliden topl late villafranchian central europ impli origin former earlier form morpholog close r macrorhinus topl perfect preserv cranial structur made possibl observ remnant palat ridg morpholog nasal turbin r macro rhinus cimmerius subsp nov
D002685;D014070
T023;T015
36,301,411
loneli myanmar older popul mix method investig littl known loneli lower middl incom countri studi investig loneli older popul myanmar use mix method approach
D008132;D000375
T033;T040
36,301,408
equiti agetech age well technolog driven place role social determin design ai base assist technolog agetech involv use emerg technolog support health well independ live older adult paper focus agetech base artifici intellig ai may better support older adult remain live environ longer provid social connected support wellb mental health enabl social particip order assess better understand posit well negat outcom ai base agetech critic analysi ethic design digit equiti polici pathway requir crucial question ai base agetech may drive practic equit inclus multilevel solut support healthi activ ageingin paper aim show focus equiti key ai base agetech realiz full potenti propos equiti extra benefit minimum requir explicit aim design ai base health tech mean social determin affect use access technolog address explor complex manag crucial element ai base agetech may potenti creat exacerb social inequ marginalis ignor social determin identifi bias standard access main ethic issu context subsequ make recommend inequ stem form ai base agetech address
D000073656;D012656
T074;T102
36,301,402
tumor invas paradox cancer stem cell driven solid tumor cancer stem cell cscs key understand tumor growth tumor progress counterintuit effect cscs call tumor growth paradox effect tumor higher death rate may grow larger tumor lower death rate extend model tumor growth paradox includ spatial structur consid cancer invas use agent base model correspond partial differenti equat model demonstr prove mathemat tumor invas paradox larger cell death rate lead faster invas speed test result generic hypothet cancer typic growth rate typic treatment sensit find tumor invas paradox may play role continu intermitt treatment seem essenti fraction treatment note attempt made fit model specif cancer thus result generic theoret
D008954;D009369
T191;T075
36,301,378
groundwat risk assess irrig purpos base salin indic appli southeastern tunisia groundwat resourc increas demand support human activ econom develop natur clean resourc threaten human natur pollut protect groundwat becom challeng urban rural communiti work aim develop simpl effect approach assess risk aquif pollut delin risk zone aquif risk index ari present overal indic risk groundwat pollut ari calcul use groundwat vulner index gvi normal water qualiti index wqi multi linear regress mlr model use assign weight paramet model appli valid koutin area southern tunisia result reveal groundwat studi area character low moder risk fifti six percent total studi area present low risk remain studi area classifi medium risk primarili wadi lowland plain ari consid intrins characterist aquif groundwat qualiti assess risk pollut approach develop assess groundwat risk simpl implement realist effici avi parametr approach use aquif data without lose inform method assist academ groundwat resourc manag delin risk area protect groundwat resourc pollut
D060587;D054712
T081;T070;T034;T082
36,301,376
estim sorption desorpt characterist biosorb lantana camara leav remov pb ii ion wastewat studi point method regard remov pb ii ion water treatment lantana camara leav biosorb lclb sorption process investig vari differ paramet ph contact time adsorb dose initi metal ion concentr temperatur g sorbent dose min contact period pb ii ion solut initi metal ion concentr mgl result maximum elimin optimum ph temperatur k lclb adsorpt process spontan exotherm maximum monolay adsorpt mgg pb ii sorption use lclb adsorpt pb ii ion use lclb r follow pseudo second order kinet spectroscop character done fourier transform infrar ft ir analysi scan electron microscop sem imag captur morpholog character desorpt experi reveal hydrochlor acid strong potenti eluent pb ii ion desorpt find propos lclb use effectu cost effect biosorb expuls pb ii ion
D032410;D014874
T131;T002
36,301,375
clinicopatholog characterist prognost factor elder small intestin adenocarcinoma use propens score match analysi studi base seer databas small intestin adenocarcinoma sia scant diseas adequ clinic trial prognost factor still unclear especi elder patient articl aim explor clinicopatholog present treatment outcom predictor small intestin adenocarcinoma patient age year older
D000230
T191
36,301,373
influenc industri discharg long term dynam abiot biotic resourc lavaca bay texa usa current studi seek identifi possibl anthropogen andor natur environment stressor may account long term declin ecosystem health lavaca bay texa usa formosa plastic corpor institut monitor industri discharg bay fix point station quarter sampl comprehens measur includ organ inorgan solut surfac water porewat sediment sediment content plankton nekton infaun bentho paramet trend chang time due climat freshwat inflow event andor season chang biolog communiti structur sediment chang distanc discharg site domin character communiti structur three four taxa compris individu nekton trawl gill net phytoplankton zooplankton ichthyoplankton sampl sediment becam sandier time away discharg surfac water porewat refer r station station near discharg site similar hydrograph biolog trend time indic long term impact due discharg howev measur organ contamin non detect method insensit ambient concentr thus still known contamin play role long term declin ecosystem health lavaca bay furthermor four r station sampl discharg site possibl trend r station repres natur background futur studi includ r station lower detect limit contamin
D017753;D061006
T083;T070;T082
36,301,359
assess groundwat salin use princip compon analysi pca case studi mewat nuh haryana india present studi princip compon analysi pca use investig process control groundwat salin mewat nuh district haryana india twenti groundwat sampl collect salin affect area march april month year analyz chemic variabl ph ec ca mg na k formula see text cl formula see text tds total hard three princip compon select base eigen valu explain total variat year respect first princip compon pc identifi salin second princip compon pc alkalin third princip compon pc describ pollut year comparison made sampl collect found increas salin compar show increas vulner aquif mewat account declin rainfal recharg also evid declin recharg also trigger recharg sourc thus impact pollut pronounc compar
D014874;D060587
T081;T131;T070;T082
36,301,357
exploratori research influenti factor china sulfur dioxid emiss base symbol regress amount china sulfur dioxid emiss remain signific larg recent year reduc sulfur dioxid emiss key find lead factor affect sulfur dioxid emiss take measur control accord order investig influenti factor sulfur dioxid emiss various provinc data sulfur dioxid emiss provinc china collect establish symbol regress model explor relationship gdp x total popul x total energi consumpt x thermal power instal capac x sulfur dioxid emiss depend variabl provinc result show amount china total sulfur dioxid emiss sulfur dioxid emiss provinc meet environment kuznet curv ekc influenti degre factor affect china sulfur dioxid emiss gdp total energi consumpt thermal power instal capac total popul provinc primari factor gdp lowest averag total energi consumpt averag thermal power instal capac averag sulfur dioxid emiss also relat low provinc primari factor gdp show obvious geograph characterist provinc primari factor total energi consumpt distribut southern china base research result control measur also put forward
D013458;D002245
T131;T197;T123
36,301,354
hydrogeochemistri groundwat qualiti assess ambagarh chowki chhattisgarh india current studi focus hydrogeochemistri ambagarh chowki groundwat main aim studi evalu water qualiti drink irrig use hydrogeochemistri groundwat purpos various physicochem paramet like ph electr conduct ec total hard th chlorid cl fluorid f calcium ca magnesium mg sodium na potassium k bicarbon hco sulfat analyz major domin ion groundwat found cation ca mg na k anion order hco cl f ph sampl groundwat rang neutral alkalin natur among analyz paramet groundwat safe drink purpos except ion bicarbon content also exceed permiss limit suitabl drink purpos potenti health hazard element fluorid vari mgl posit associ ph na hco content groundwat drink water qualiti index wqi fluctuat report groundwat suitabl drink purpos except one sampl unsuit drink irrig water qualiti assess area perform evalu sodium adsorpt ratio sar permeabl index pi kelli ratio kr magnesium hazard ratio mhr percent sodium na potenti salin ps residu sodium carbon rsc wherea groundwat good suitabl irrig use exclud pi mhr rsc ps unsuit continu irrig hydrogeochemistri groundwat evalu correl piper gibb geochem analysi piper trilinear diagram reflect ca mg hco type water main contribut approxim entir sampl groundwat differ ion groundwat origin rock water interact silic carbon weather miner
D014874;D060587
T081;T131;T070;T082
36,301,348
hydrogeochemistri qualiti evalu groundwat impact human health north tripura india groundwat contamin becom alarm threat provis ecosystem servic natur resourc high level groundwat contamin observ northeastern state particular north tripura district therefor present studi consid region case studi evalu hydrogeochem faci heavi metal pollut irrig indic impact human health investig collect total groundwat sampl north tripura district hydrogeochem faci piper plot reflect ca mg hco na hco domin water type gibb plot identifi domin rock water interact process groundwat hydrochemistri geochem plot indic domin silic weather ion exchang carbon dissolut process groundwat mineralis order trace metal contamin follow fe zn mn cu pb result heavi metal indic suggest sampl high risk due high fe contamin risk heavi metal indic associ rise elev southern part north tripura find health risk assess studi impli children face much carcinogen non carcinogen risk adult unsaf level fe multivari statist tool appli unravel interrelationship among ion trace metal well probabl hydrogeochem process groundwat result wilcox ussl plot suggest sampl meet irrig suitabl criteria besid analysi suggest better insight identifi hydrogeochem process control groundwat chemistri suitabl groundwat irrig drink purpos studi also suggest treatment sustain manag groundwat resourc compulsori reduc trace metal contamin public use
D014874;D060587;D019216;D014131
T123;T121;T070;T082;T131;T196;T081
36,301,338
safeti efficaci daratumumab chines patient relaps refractori multipl myeloma phase dose escal studi mmi daratumumab monotherapi demonstr favor safeti efficaci relapsedrefractori multipl myeloma rrmm patient global phase gen phase sirius studi mmi evalu daratumumab monotherapi specif chines patient rrmm part open label phase dose escal studi includ patient prior line therapi part includ patient receiv proteasom inhibitor pi immunomodulatori drug imid experienc diseas progress last regimen patient receiv intraven daratumumab mgkg mgkg part mgkg part primari endpoint dose limit toxic dlt part pharmacokinet part advers event ae fifti patient enrol first patient part receiv daratumumab mgkg remain patient part receiv daratumumab mgkg daratumumab mgkg group n patient receiv median prior line therapi refractori pi imid refractori last prior therapi dlts occur thirti six patient report grade treatment emerg ae thirteen patient experienc infus relat reaction month median follow overal respons rate median progress free surviv pfs overal surviv os month reach respect month pfs os rate pharmacokinet result n consist studi safeti pharmacokinet efficaci daratumumab monotherapi confirm chines patient rrmm trial regist clinicaltrialsgov nct
D009101
T191
36,301,322
synthesi polysubstitut oxabicyclo hexan via visibl light induc energi transfer synthesi bicycl scaffold attract grow interest high import modern pharmaceut develop report strategi access polysubstitut oxabicyclo hexan singl oper readili access benzoylform ester bicyclo butan via visibl light induc triplet energi transfer catalysi process propos involv formal photocycloadditionbackbon c h abstractionaryl group migrat sequenc divers rang hetero aryl group success underw migrat backbon c posit provid previous inaccess bicycl molecul ester group product serv handl downstream manipul thus offer opportun rapid build molecular complex access new sp rich chemic space
D006586;D008027
T070;T109
36,301,318
ischem heart diseas chronic cad myocardi ischemia reduct perfus therefor oxygen defici vital cardiomyocyt thus primari secondari prophylaxi myocardi infarct complic
D017202;D003324;D009203
T047
36,301,310
environment friend absorpt anesthet gase first experi commerci anesthet gas captur system anesthet gase potent greenhous gase current releas atmospher remain mani year strategi reduc carbon footprint anesthesiolog without compromis patient safeti urgent need sinc sever depart anesthesiolog instal anesthet gas captur system anesthet gase collect articl aim describ anesthet gas captur system contrafluran give overview first experi four depart anesthesiolog work new devic daili clinic routin contrafluran system present new concept surgic set potenti reduc carbon footprint anesthesiolog howev order accur estim co equival save inform concern reprocess data pharmacokinet anesthet gase need applic contrafluran system daili clinic routin feasibl anesthesiologist awar specif issu order minim carbon footprint remain essenti implement specif recommend posit paper german societi anaesthesiolog intens care medicin dgai profession associ german anaesthesiologist bda ecolog sustain anesthesiolog intens care medicin support research
D018685;D000776;D000074382
T121;T122;T091;T197
36,301,303
metabol featur innat lymphoid cell innat adapt immun cell found distinct tissu nich orchestr immun respons requir intrins tempor metabol adapt coordin activ immun respons cascad dysregul program key featur immunosuppress direct indirect metabol immun cell reprogram may offer new approach modul immun cell behavior therapi overcom dysregul review explor metabol regul lymphocyt beyond classic cell subset focus innat lymphoid cell ilc famili highlight distinct metabol characterist cell impact environment factor receptor could alter immun cell function manipul metabol pathway potenti prevent treat various diseas
D008214;D007113
T032;T025
36,301,301
psycholog servic extend public health diseas manag approach crimin justic set introduct covid brought renew attent physic mental health need underserv popul set assist receiv servic introduct present six articl special section diseas manag approach use within crimin justic set address need articl span rang set includ prison jail mental health court forens set crisi unit collect articl special section discuss medic condit substanc use mental health provid inform divers approach taken across various set manag physic mental health challeng involv crimin justic system psycinfo databas record c apa right reserv
D001523;D000086382;D019966
T033;T047;T067;T048
36,301,300
psycholog servic wonder journey start journey origin editori team associ editor sheila brandt leon green jill oliveira berri morgan sammon gari vandenbo serv manag editor begin decid psycholog servic divis journal would craft content address interest need membership primarili serv public servic interdisciplinari system want increas particip psychologist nonacadem set editori process especi women ethnic minor throughout tenur reach divis leadership especi past presid thought input would know divis interest psycinfo databas record c apa right reserv
D007857;D013850
T078;T041;T054
36,301,273
work memori model weird test model work memori non weird sampl correct cockcroft report error work memori model weird test model work memori non weird sampl kate cockcroft neuropsycholog jul vol articl tabl verbal stm verbal wm mean standard deviat set bold median th p th p valu set bold tabl bold valu appropri data distribut tabl correl lr subtest ooo mrx sr subtest incorrect list respect respect tabl df four factor model list onlin version articl correct follow abstract origin articl appear record object mani compet work memori model general formul young adult typic student sampl western educ industri rich develop weird context whether model adequ conceptu work memori wm young adult non weird context unclear
D008570
T041
36,301,259
nucleoplasm lamin c rapid accumul site nuclear envelop ruptur baf cgas mammalian cell nuclei nuclear lamina nl under nuclear envelop ne maintain nuclear structur nuclear lamin major structur compon nl involv protect ne ruptur induc mechan stress howev specif role lamin repair ne ruptur fulli determin analys use immunofluoresc live cell imag reveal nucleoplasm pool lamin c rapid accumul site ne ruptur induc laser microirradi mous embryon fibroblast accumul lamin c ruptur site requir immunoglobulin like fold domain bind barrier autointegr factor baf nuclear local signal accumul nuclear baf cytoplasm cyclic gmp amp synthas cgas ruptur site part depend lamin ac result suggest nucleoplasm lamin c baf cgas concert accumul site ne ruptur rapid repair
D034904;D009685
T026;T123;T116
36,301,258
phenol compound virgin oliv oil approach synthesi analogu virgin oliv oil voo main fat consum popul mediterranean basin phenol compound minor compon fat known respons divers health benefit consum regular diet accord numer investig benefit most relat phenol tyrosol hydroxytyrosol secoiridoid deriv ligstrosid oleuropein oleocanth oleacein compound present low concentr standard commerci avail hamper studi mechan under biolog activ order contribut better knowledg bioactiv compound metabolit must avail high puriti suffici amount assay chemic synthesi consid conveni way obtain compound review focus synthesi repres voo compound name ligstrosid oleuropein oleocanth oleacein analogu
D010636
T121;T109
36,301,252
subsecond three dimension nitrogen magnet reson imag facilit parahydrogen base hyperpolar magnet reson imag mri provid uniqu inform intern structur function live organ non invas way use convent proton mri observ real time metabol hamper domin signal water fat abund live organ heteronuclear mri conjunct hyperpolar method encount issu work polar n nuclei n fampridin drug use treatment multipl sclerosi level nuclear magnet reson nmr experi mri studi use spin lock induc cross combin signal amplif revers exchang consequ three dimension n mri hyperpolar n label drug acquir signal nois ratio addit nmr signal enhanc n enrich fampridin fampridin natur abund n nuclei compar explan differ propos
D008279;D011522
T060;T196;T170;T059
36,301,242
preliminari analysi cervic cancer immunotherapi cervic cancer one common gynecolog malign worldwid although vaccin cervic cancer screen includ human papillomavirus test cytolog test colposcopi develop rapid recent year effect reduc cervic cancer mortal cervic cancer remain malign higher femal fatal rate worldwid high risk socioeconom disadvantag group combin platinum paclitaxel chemotherapi possibl addit bevacizumab current treatment choic advanc cervic cancer remiss purpos therefor new therapeut strategi need local advanc metastat cervic cancer make preliminari analysi cervic cancer immunotherapi
D002583;D030361
T047;T191
36,301,238
vaccinia virus btb kelch protein c f inhibit nf b activ vaccinia virus vacv encod score protein suppress host innat immun mani target intracellular signal pathway lead activ inflamm transcript factor nf b play critic role host respons infect target mani virus includ vacv encod nf b inhibitor interfer differ stage signal pathway report vacv protein c f addit inhibitor pathway c f btb kelch protein express earli infect non essenti virus replic affect outcom infect vivo use report gene assay rt qpcr analys endogen gene express elisa btb kelch protein shown diminish nf b activ reduc transloc p nucleus c f th th nf b inhibitor encod vacv remark everi case test individu protein affect virul vivo therefor non redund function last immunis vacv strain lack c induc stronger cd cell respons better protect virus challeng
D014616;D014615
T005;T047
36,301,230
caus death data fetal death file object report present data fetal caus death matern age matern race hispan origin fetal sex period gestat birthweight plural
D005313;D006630
T098;T046
36,301,229
covid death rate urban rural area unit state death rate unit state higher rural urban area differ grown last decad death rate lead caus death higher rural urban area death due covid becam third lead caus death unit state report present covid death rate rural urban area sex age group age rate present six categori urban accord deced counti resid urban area includ larg central metropolitan larg fring metropolitan medium metropolitan small metropolitan rural area includ micropolitan noncor nonmetropolitan
D000086382
T047;T067
36,301,220
comparison self report alcohol consumpt ethyl glucuronid hair sampl year old treat dsm alcohol use disord lack evid consist self report alcohol consumpt srac concentr ethyl glucuronid hair hetg among elder patient treat exclus alcohol use disord aud henc studi assess consist two measur patient total patient aud assess srac use form hetg week treatment conclus patient group accord srac gday correspond hetg concentr pgmg excess consumpt extent underreport overreport examin crosstabul inter rater reliabl report kappa correl associ effect modif examin condit logist regress due multitest p valu consid signific underreport found patient overreport patient kappa coeffici vari hetg like detect low moder high alcohol consumpt compar srac or p valu srac hetg differ signific respect identif abstin p inconsist outcom measur found consider number patient studi examin consist srac specif direct biomark alcohol popul seem warrant
D000437
T048
36,301,219
connectom base predict model smoke sever smoker function connect within network could provid framework character neurobiolog mechan nicotin addict studi examin brain region function connect respons smoke cue establish brain behaviour relationship smoker sixti seven male smoker enrol scan perform cue reactiv stroop task whole brain analysi approach connectom base predict model cpm conduct data cue reactiv task identifi network could predict smoke sever shen atlas templat brain behaviour relationship verifi differ brain state stroop task cpm identifi smoke sever relat network indic signific correl predict actual smoke sever score r p identifi network main involv canon network implic reward process motorsensori network salienc network execut control frontopariet network network strength stroop task margin signific predict smoke sever score r p partial replic brain behaviour relationship cpm result identifi whole brain neural network relat smoke sever cross valid aal shen atlas find contribut profound insight neural substrat under smoke sever
D063132
T017;T091
36,301,218
associ opioid use disord blunt heart rate variabl among opioid treat chronic pain patient given sever ongo opioid epidem essenti understand mechan risk develop mainten opioid use disord oud aim current larg scale psychophysiolog investig test whether patient oud lower rest state high frequenc heart rate variabl hf hrv without oud control sociodemograph clinic confound addit test whether hf hrv associ opioid crave popul particip cross section studi chronic pain patient femal treat long term opioid therapi oud diagnosi determin psychiatr interview hf hrv measur rest baselin comput associ oud rest state hf hrv control age gender race pain sever emot distress opioid dose opioid crave measur visual analogu scale assess whether hf hrv associ crave result show rest hf hrv signific lower patient oud without oud p indic deficit autonom flexibl oud diagnosi p oud sever p associ lower hf hrv regress model account rang confound addit lower hf hrv signific weak correl heighten opioid crave r p overal find suggest rest state hf hrv may serv valid biomark addict among peopl long term opioid therapi
D059350;D009293
T184;T047;T048
36,301,217
intermitt access oxycodon decreas dopamin uptak nucleus accumben core abstin major obstacl treat opioid use disord persist drug seek crave period abstin believ contribut relaps dopamin transmiss mesolimb pathway posit contribut opioid reinforc process dopamin influenc drug seek complet elucid examin whether opioid seek abstin associ alter dopamin transmiss femal male rat self administ oxycodon intermitt access schedul reinforc follow self administr rat underw forc abstin period cue induc seek test conduct assess oxycodon seek one day follow final seek test rat sacrif perform ex vivo fast scan cyclic voltammetri western blot nucleus accumben rat display reduc dopamin uptak rate abstin day abstin day compar oxycodon nave rat abstin day rat reduc phosphoryl dopamin transport addit local applic oxycodon nucleus accumben reduc dopamin uptak oxycodon nave rat rat oxycodon abstin abstin day abstin day observ suggest abstin oxycodon result dysfunct dopamin transmiss may contribut sustain oxycodon seek abstin
D009714;D003042
T121;T023;T131;T109
36,301,216
neural signal methamphetamin crave seek intensifi bupropion ventral tegment area cortico accumben circuitri mice previous bupropion bup norepinephrin ne dopamin da transport blocker nicotin acetylcholin receptor nachr antagonist found intensifi methamphetamin meth crave behaviour mice intens crave caus relaps drug depend studi character local field potenti lfp pattern brain region associ meth condit place prefer cpp enhanc bup male swiss albino icr mice implant lfp electrod ventral tegment area vta medial prefront cortex mpfc nucleus accumben core nacc anim receiv session learn associ inject effect mgkg meth normal salin contextu environ meth salin pair compart condit phase total mgkg bup given anim lfp behaviour record cpp apparatus post condit phase result show increas cpp score number entri meth pair zone well chang vta mpfc nacc spectral power coher among area associ meth cpp treatment bup increas vta delta gamma decreas mpfc alpha increas nacc gamma decreas gamma ii power coher analys reveal bup decreas gamma ii vta mpfc increas beta gamma vta nacc connect altogeth bup produc addit effect meth cpp alon find demonstr chang neural circuit activ associ meth cpp intensifi bup moreov modul neda system andor nachr action vta cortico accumben loop might underli meth crave depend
D017557;D008694
T121;T023;T131;T109
36,301,215
classic psychedel alcohol use disord systemat review human anim studi classic psychedel refer substanc lyserg acid diethylamid lsd psilocybin ayahuasca mescalin induc alter state conscious act main ht receptor recent interest psychedel pharmacolog treatment psychiatr disord increas signific includ use problemat use alcohol systemat review aim analys last two decad studi examin relationship classic psychedel alcohol consumpt search pubm psycinfo human preclin studi publish januari decemb search identifi public select studi includ human studi n general show promis data seem indic classic psychedel could help reduc alcohol consumpt nevertheless studi present methodolog concern low number particip lack control group difficulti determin effect classic psychedel isol hand preclin studi n investig effect compound voluntari alcohol consumpt scarc show conflict data among compound psilocybin seem show consist data indic compound could potenti candid treat alcohol use disord absenc understand biolog andor psycholog mechan studi includ methodolog qualiti paramet need final determin effect classic psychedel alcohol consumpt
D006213;D000437
T121;T131;T048
36,301,214
cocain fall oblivion volit initi choic trial face choic anim quit drug favour varieti nondrug altern recent found rather unexpect choic nondrug altern fact inflex habitu one possibl contribut factor habitu choic intermitt uncontrol choic trial previous studi ask whether extent volit control occurr choic trial could chang anim prefer prevent habitu choic rat train nosepok hole trigger present two oper lever one associ cocain saccharin rat free choos among two lever obtain correspond reward lever retract rat self initi next choic trial overal found volit control choic trial chang prefer rat prefer saccharin cocain select option almost exclus intrigu repeat choic consumpt saccharin rat transient lost interest option ie due sensori specif satieti switch cocain prefer instead paus long period time reiniti choic trial saccharin find suggest volit initi choic trial rat fail consid cocain option discuss possibl associ mechan explain perplex behaviour
D003042
T121;T131;T109
36,301,213
within person declin pregnanc smoke observ prior pregnanc awar evid across two independ observ cohort decreas consumpt nicotin drug pregnanc appear cross speci phenomenon mechan capabl interrupt addict process could elucid whether pregnanc influenc smoke behaviour independ women knowledg pregnanc howev consid use repeat measur analysi varianc anova estim within person chang mean cigarettesday smoke across estim date concept prior individu report date pregnanc recognit use longitudin smoke data two independ observ cohort grow healthi guh n midwest infant develop studi mid n particip smoke averag half packday month immedi concept sd cigarettesday guh mid respect observ within person declin smoke concept guh ci p mid ci p guh ci p mid ci p women awar conceiv even women quit women plan conceiv exclud analys pregnanc may interrupt smoke relat process via mechan previous consid plausibl candid direct futur research discuss
D061485;D016540
T121;T109;T200;T055;T074
36,301,212
cannabi use select modul circul biomark blood schizophrenia patient cannabi use disord frequent schizophrenia patient associ earlier age onset poor schizophrenia prognosi serotonin receptor htar involv psychosi like akt kinas known modul thc likewis endocannabinoid system dysregul suggest schizophrenia presenc molecul blood make interest target evalu patient minim invas techniqu aim present studi evalu htar protein express akt function status platelet homogen subject diagnos schizophrenia cannabi use disord condit compar age sex match control subject addit endocannabinoid pro inflammatori interleukin il level also measur plasma subject result show platelet htar activ phospho ser akt protein express signific increas schizophrenia subject wherea patient dual diagnosi schizophrenia cannabi use disord show signific chang similar plasma concentr anandamid lipid mediat pea dea well pro inflammatori il signific increas schizophrenia dual subject result demonstr schizophrenia subject show differ circul marker pattern depend associ diagnosi cannabi use disord support hypothesi could differ under mechan may explain clinic differ among group moreov provid first preliminari evid peripher measur molecul interest bigger prospect studi subpopul
D012559;D002188;D002189
T121;T167;T109;T047;T002;T048
36,301,211
plasma tau nfl gfap uchl candid biomark alcohol withdraw associ brain damag pilot studi translat studi investig plasma tau protein neurofila light chain nfl glial fibrillari acid protein gfap ubiquitin carboxi termin hydrolas l uchl establish biomark neurolog injuri predict biomark alcohol withdraw associ brain toxic clinic studi patient sever alcohol use disord aud hospit alcohol cessat ac n compar sever aud patient least month abstin n overal patient men age year sd tau nfl gfap uchl level measur use simoa analys quasipoisson regress model adjust age sex nfl level higher ac group p ac group tau p uchl p level posit associ dose diazepam per weight tau p nfl p uchl p level higher presenc sign wernick encephalopathi n preclin studi nfl gfap level assess alcohol depriv effect ade procedur n control wistar rat n furthermor ade rat prospect assess h week ac pair sampl wilcoxon mann whitney test nfl level higher ade model control rat p p higher p plasma tau nfl uchl potenti biomark brain suffer alcohol withdraw
D000437;D013375
T184;T048
36,301,210
prognost factor low risk drink relaps alcohol use disord multimod analysi studi aim specifi determin low risk alcohol drink relaps differ time point detoxif patient sever alcohol use disord aud fifti four patient aud healthi control hc evalu earli abstin underw clinic neuropsycholog neuroimag structur mri fdg pet investig patient aud subsequ classifi low risk drinker lr relaps r base alcohol drink month year discharg use medic record self report drink estim follow base alcohol status compar hc r alexithymia lower grey matter volum midbrain hypermetabol cerebellum hippocampi base alcohol status compar hc r sever nicotin depend lower episod work memori perform lower grey matter volum amygdala ventromedi prefront cortex anterior cingul gyrus hypermetabol cerebellum hippocampi anterior cingul gyrus moreov r bilater frontal hypometabol wherea lr present right frontal hypometabol nicotin depend memori impair structur brain abnorm region involv impuls decis make might contribut year relaps treatment outcom year may also associ imbal hypermetabol limbic system hypometabol frontal execut system final cerebellar hypermetabol alexithymia may determin relaps month year
D000437
T048
36,301,208
embryon ethanol exposur induc ectop hcrt mch neuron outsid hypothalamus rat zebrafish role ethanol induc behaviour disturb embryon exposur ethanol increas risk alcohol use disord human stimul alcohol relat behaviour differ anim model evid rat zebrafish suggest phenomenon induc ethanol low moder concentr involv stimulatori effect neurogenesi densiti hypothalam neuron express peptid hypocretinorexin hcrt melanin concentr hormon mch known promot alcohol consumpt build report zebrafish show ethanol induc ectop express hcrt neuron outsid hypothalamus investig whether embryon ethanol exposur also induc ectop peptid neuron rat similar zebrafish affect morpholog characterist ectop neuron function role ethanol induc disturb behaviour demonstr rat ethanol low moder dose addit increas hcrt mch neuron later hypothalamus normal concentr induc ectop express peptid neuron anterior nucleus accumben core ventromedi caudat putamen previous observ caus morpholog chang relat normal locat hypothalam neuron similar rat embryon ethanol exposur low moder dose zebrafish induc ectop hcrt neuron anterior hypothalamus alter morpholog notabl laser ablat ectop hcrt neuron block behaviour effect induc ethanol exposur includ increas anxieti locomotor activ find suggest ectop peptid neuron function contribut ethanol induc behaviour disturb relat overconsumpt alcohol
D000431;D009474;D000068797;D011297
T121;T123;T116;T025;T109;T037
36,301,207
gpr agonist rti reduc alcohol drink seek mice gpr orphan g protein coupl receptor consid potenti target treat neuropsychiatr disord includ addict knowledg gpr function stem knockout mous studi vivo pharmacolog still scarc examin effect novel brain penetr agonist rti sever alcohol relat behaviour mous intermitt access two bottl choic paradigm compound reduc excess voluntari alcohol drink water drink intact observ cbl mice well control gpr knockout mice demonstr efficaci specif drug vivo drink dark paradigm rti also reduc bing like drink behaviour control gpr knockout mice confirm alcohol consumpt reduc effect vivo specif drug cbl mice train alcohol self administr rti decreas number nose poke h session reduc number lick burst lick suggest reduc motiv obtain alcohol final rti induc place prefer avers reduc express condit place prefer alcohol indic reduct alcohol reward seek altogeth data show rti limit alcohol intak distinct condit requir consummatori behaviour oper respons associ contextu cue rti therefor promis lead compound evalu gpr therapeut target alcohol use disord broad rti repres uniqu tool better understand gpr function disentangl receptor role develop adult perhap address neuropsychiatr disord
D000437
T048
36,301,206
glua lack ampa receptor nucleus accumben core shell contribut incub oxycodon crave male rat one challeng issu treatment substanc use disord includ misus opioid oxycodon persist vulner relaps often trigger cue context previous associ drug use rat cue induc crave progress intensifi incub withdraw extend access self administr sever class misus drug includ psychostimul cocain methamphetamin psychostimul incub associ strengthen excitatori synaps nucleus accumben nac incorpor amino hydroxi methyl isoxazol propion acid receptor lack glua subunit therefor ca permeabl cp ampar cp ampar upregul occur stimul requir express incub known similar mechan contribut incub oxycodon crave use male rat establish incub occur withdraw day wd persist wd use cell surfac biotinyl found surfac level ampar subunit glua glua elev nac core shell oxycodon rat wd although wane wd next use intra nac inject select cp ampar antagonist naspm seek test demonstr cp ampar blockad either subregion decreas oxycodon seek wd wd incub wd effect salin self administ anim naspm result suggest cp ampar persist synaps wd even total cell surfac level wane result suggest common neurobiolog mechan contribut express incub crave oxycodon psychostimul
D013375;D003042
T184;T121;T109;T131;T048
36,301,205
gender differ cocain induc hyperact dopamin transport traffick plasma membran well known cocain induc stimul effect dopamin transport dat traffick plasma membran dopaminerg neuron present studi examin cocain induc hyperact along cocain induc dat traffick recoveri rate dopaminerg system femal rat comparison male rat demonstr interest gender differ femal rat initi sensit cocain male rat term dat traffick hyperact induc cocain particular intraperiton ip administr mgkg cocain induc signific hyperact dat traffick femal rat male rat repeat cocain exposur ie ip administr mgkg cocain everi day day day cocain induc hyperact femal rat gradual becam clear pattern two phase first phase hyperact last minut second phase last hour begin min clear differ male rat also demonstr striatal dat distribut femal rat may recov faster male rat multipl cocain exposur nevertheless despit remark gender differ recent develop long act cocain hydrolas known coch fc similar effect block cocain induc dat traffick hyperact male femal rat
D050483;D003042
T123;T121;T116;T109;T192;T131
36,301,201
photoinduc dual shape programm coval adapt network remark mechan properti classic shape memori polym featur shape reconfigur temporari state coval adapt network contain revers bond enabl perman state reconfigur topolog rearrang via dynam bond exchang yet attract dual shape programm limit actuat mode direct heat transfer poor mechan properti restrict control precis function herein present method creat nanocomposit photomodul dual shape programm remark mechan properti lead field coval adapt network mxene whose phototherm effici reveal regul etch method delamin introduc polyurethan network upon adjust light intens dual shape programm perman temporari state could accomplish exhibit potenti inform recognit photowrit paper etc furthermor owe dynam transcarbamoyl elev temperatur phototrigg dual shape programm could maintain self heal reprocess
D011108;D053761
T104;T122;T073
36,301,196
epitop map anti mous cxcr monoclon antibodi cx mab use alanin scan method cxc chemokin receptor cxcr member g protein coupl receptor famili high express helper type cell cytotox lymphocyt ctls natur killer cell cxcr play critic role local expans effector like ctls tumor microenviron potenti antitumor respons therefor develop anti cxcr monoclon antibodi mab essenti evalu immun microenviron tumor use n termin peptid immun previous develop anti mous cxcr mcxcr mab cx mab rat igg kappa use flow cytometri western blot studi determin critic epitop cx mab enzym link immunosorb assay elisa use alanin scan ala scan method alanin scan ala scan method although first perform elisa ala scan use one alanin substitut peptid mcxcr n termin domain amino acid could identifi cx mab epitop next perform elisa ala scan use two alanin glycin residu substitut peptid mcxcr n termin domain found cx mab recogn sa ag ag la la ya ga ha mcxcr n termin peptid result indic bind epitop cx mab includ ser ala leu tyr gli mcxcr therefor could demonstr ala scan method use determin critic epitop mab
D000409;D000911
T129;T123;T121;T116
36,301,192
chiari malform present headach associ laughter present describ case year old boy refer outpati depart one year histori headach associ laughter diagnosi investig mri brain reveal chiari type malform cm cerebellar tonsillar descent mm foramen magnum treatment manag conserv serial neuroimag symptom monitor discuss cm hindbrain malform characteris mm herniat cerebellar tonsil diagnos radiograph increas detect incident natur histori asymptomat patient usual remain asymptomat symptomat patient often show symptom improv particular paediatr popul neurosurg intervent may offer base symptom radiograph find carri complic rate
D007845;D001139
T019;T054
36,301,190
epitop map anti human cc chemokin receptor type monoclon antibodi kc cc chemokin receptor type ccr belong g protein coupl receptor superfamili local cell surfac tumor cell immun cell includ monocyt macrophag ccr receptor monocyt chemoattract protein c c motif chemokin involv progress various diseas cancer therefor develop ccr target monoclon antibodi mab desir character includ epitop mab import antibodi applic studi investig critic epitop kc commerci avail anti human ccr hccr mab conduct enzym link immunosorb assay elisa use three n termin peptid hccr demonstr kc recogn amino acid hccr perform elisa use peptid includ alanin substitut hccr kc lost reaction alanin substitut peptid da ya da ga ag result indic critic bind epitop kc includ asp tyr asp gli ala hccr
D054390;D018932
T129;T116;T192
36,301,189
photoplethysmographi base smart devic detect atrial fibril atrial fibril common experienc type cardiac arrhythmia associ substanti clinic occurr expens arrhythmia often occur silent asymptomat form reveal complic stroke congest heart failur transpir new smart devic confer effect advantag detect heart arrhythmia photoplethysmographi base smart devic shown great potenti accord previous research howev solut becom problem widespread use high avail various applic smart devic may lead substanti amount fals mislead record inform caus unnecessari anxieti regard arrhythm occurr diagnos devic profession confirm thus devic photoplethysmographi base detect atrial fibril import research devic studi point find best smart devic detect aforement arrhythmia
D017156;D001281
T060;T047;T046
36,301,174
fixat frame acupunctur moxibust shu mu acupoint combin rat shu mu acupoint combin common employ acupunctur moxibust treatment anim experi difficult implement combin uncontrol featur anim therefor urgent need design experiment devic facilit oper acupunctur moxibust shu mu acupoint rat present studi design devic equip fix plate moxibust frame rat fix plate moxibust frame detach connect allow acupunctur back chest abdomen rat meet requir shu mu acupoint combin moxibust frame made univers hose equip moxa clip ensur moxibust direct perform moxibust acupoint back chest abdomen simultan devic uniqu structur conveni oper safeti reliabl benefici develop anim experi relat acupunctur moxibust shu mu acupoint combin futur
D009071;D016740;D015670
T061;T029
36,301,173
set optim control group acupunctur anim experi base research element acupunctur anim experi main form acupunctur mechan research set control group crucial scientif reliabl research conclus research element fundament focus research element involv acupunctur anim experi studi summar current situat characterist control group relat acupoint select intervent patholog mechan acupunctur anim experi put forward question suggest refer set control group provid acupunctur anim experi futur
D032761;D015670
T062;T061
36,301,172
biblio metrolog analysi clinic applic chengshan bl ancient chines medic literatur analyz sum clinic applic regular chengshan bl acupoint ancient chines literatur
D016740;D009071;D015670
T061;T029
36,301,171
analysi clinic applic characterist acupunctur moxibust treatment menier diseas base topolog model complex network analyz applic characterist acupunctur moxibust clinic treatment menier diseas use complex network technolog provid evid select acupoint needl moxibust method treatment idea
D008575;D009071;D015670;D016740
T061;T047;T029
36,301,170
clinic observ acupotomi combin warm needl cervic spondylot radiculopathi qi blood stagnat syndrom observ clinic effect acupotomi combin warm needl cervic spondylot radiculopathi csr qi blood stagnat syndrom
D011843;D055009;D015670
T061;T047;T037
36,301,169
effect administr acupunctur stimul combin gushen zhuyu decoct lumbar function patient disc herniat investig therapeut effect acupunctur stimul combin administr gushen zhuyu tang decoct consolid kidney elimin blood stasi dckeb treatment lumbar disc herniat ldh patient
D007405;D015670
T061;T047
36,301,168
point prick method fire needl knee osteoarthr random control trial observ effect point prick method fire needl symptom knee joint physio psycholog health patient knee osteoarthr koa
D020370;D015670
T061;T047
36,301,167
effect electroacupunctur sexual develop ovarian estrogen receptor express femal adolesc obes rat observ effect electroacupunctur sexual develop ovarian estrogen receptor er express femal adolesc obes rat induc high fat diet explor under mechan improv adolesc obes
D015671;D063766
T061;T047;T033
36,301,166
effect manual acupunctur sanyinjiao sp spermatogen cell mice oligoasthenospermia induc microwav radiat observ effect acupunctur sanyinjiao sp sperm motil testicular b cell lymphomaleukelia bcl bcl associ x protein bax caspas mice oligoasthenospermia induc microwav radiat explor under mechan improv oligoasthenospermia
D015670;D008872
T061;T070;T057
36,301,165
effect electroacupunctur blood brain barrier proinflammatori cytokin il il hippocampus rat vascular dementia observ effect electroacupunctur ea blood brain barrier bbb permeabl proinflammatori cytokin interleukin il interleukin il hippocampus vascular dementia vd rat explor mechan ea treatment vd
D015140;D015671
T061;T047
36,301,164
effect herbal cake separ moxibust behavior stress reaction blood lactic acid level muscular ampkpgc signal rat chronic fatigu syndrom observ effect herbal cake separ moxibust hcsm serum lactic acid bla level ampkpgc signal pathway quadricep femori chronic fatigu syndrom cfs rat explor mechan under improv cfs
D015673;D009071
T061;T047
36,301,163
effect nape seven needl express hypoxia induc factor notch cervic intervertebr disc degener rat observ effect nape seven needl express hypoxia induc factor hif notch cervic intervertebr disc cervic disc degener cdd rat reveal under mecha nism improv cdd
D007403;D055959;D015670
T061;T023;T190;T047
36,301,162
mechan electroacupunctur zusan st delay colon inflamm cancer transform investig mechan electroacupunctur ea zusan st delay colon inflamm cancer transform mice anti inflammatori
D003110;D015671
T061;T191
36,301,161
eye acupunctur improv cerebr ischemia reperfus injuri improv autophagi via atf pathway cerebr ischemia reperfus injuri rat explor effect eye acupunctur autophagi express autophagi relat protein beclin lcb atf xbp infarct area brain tissu rat acut cerebr ischemia reperfus injuri ciri explor mechan under improv ciri
D015670;D002545;D015427
T061;T047;T046;T037
36,301,160
electroacupunctur amelior inflammatori respons mice acut myocardi ischemia regul vascular endotheli growth factor cvascular endotheli growth factor receptor pathway observ effect electroacupunctur ea cardiac function lymphat marker macrophag inflammatori cytokin acut myocardi ischemia ami mice explor mechan improv ami
D015671;D017202
T061;T047
36,301,150
address complex heterogen profil adolesc girl sexual abus childhood sexual abus csa may devast effect yet consider heterogen among adolesc girl experienc address heterogen could help tailor practic particular need object identifi profil among adolesc girl sexual abus determin whether exhibit distinct outcom particip drawn child protect sampl adolesc girl sexual abus contact n abus stress event measur use rate scale complet research assist self report questionnair cope strategi cognit apprais psycholog symptom measur use self report questionnair latent class analysi conduct use abus stress event indic multinomi logist regress analys use compar class outcom five grade class identifi sourc stress servic stressor csa stressor csa famili stressor multipl sourc stress class associ distinct profil cope strategi cognit apprais psycholog symptom conclus recommend clinician move beyond one size fit approach tailor practic adolesc need
D002650
T048
36,301,140
preserv phosphoproteom clinic biopsi use quick freez collect devic grow interest proteom analys tissu biopsi reveal pathophysiolog identifi biomark current gold standard collect tissu biopsi preserv proteom post translat modif flash freez liquid nitrogen ln howev mani clinic set option due unavail ln train personnel rapid biospecimen process address need develop proof concept quick freez prototyp devic rapid freez biospecimen point care preserv phosphoproteom without need ln object develop devic demonstr eas use confirm abil ship exist cold chain logist evalu cool perform ie cool tissu sampl c second c second maintain temperatur minut context preserv proteom tissu biospecimen demonstr feasibl perform prototyp benchmark flash freez ln use murin melanoma patient deriv xenograft model subject total bodi irradi elicit phosphosign dna damag respons network tumor harvest quadrisect two part tumor snap frozen ln remain two part rapid cool prototyp quick freez biospecimen contain phosphoprotein profil liquid chromatographi tandem mass spectrometri quantifi target multipl reaction monitor ms overal phosphoproteom equival biospecimen process use quick freez contain use ln gold standard although measur subset phosphopeptid devic frozen specimen variabl ln frozen specimen prototyp devic form framework develop commerci devic improv tissu biopsi preserv measur import phosphosign molecul
D020543;D040901
T123;T091;T116
36,301,139
decarbon biobank potenti new scientif area call reduc entir remov carbon footprint ongo activ collect term decarbon becom increas vocal health care number recent high profil consensus statement call encourag biobank field one foundat health care research infrastructur consid decarbon potenti novel research area term molecul equip use research current articl provid summari roundtabl discuss isber annual meet exhibit highlight current knowledg gap challeng opportun field particular technolog innov greater awar current situat behavior chang import piec puzzl improv futur decarbon biobank even eventu implement rout resourc abund resourc restrict set might distinct differ articl set foundat rais awar subject subsequ step need undertaken
D018070
T093
36,301,132
repair stenot bicuspid aortic valv extens leaflet shave commissuroplasti surgic repair bicuspid aortic valv children shown good outcom repair done delic use nativ valv tissu without use patch materi patient year old boy diagnos stenot bicuspid aortic valv supravalvular aortic stenosi balloon valvuloplasti year old video tutori give detail inform repair aortic valv reshap aortic cusp reconstruct aortic commissur
D000082882;D001024;D063126;D001022
T061;T019;T047
36,301,128
transcriptom reveal dysfunct pancreat islet wound heal sever burn mice sever burn patient higher risk diabet mellitus heal mechan remain unclear therefor purpos studi explor influenc burn pancreat islet mice wound heal
D002056;D007515
T023;T037
36,301,127
tissu plasminogen activ resist earli predictor posttraumat venous thromboembol prospect studi clott research group venous thromboembol vte remain frequent postinjuri complic well establish nonmodifi risk factor hypothes fibrinolysi shutdown sd measur thromboelastographi teg would independ risk factor vte trauma patient
D054556;D001778
T047
36,301,102
statist chemic thermodynam energet behavior count gibb theori revisit one major tenet gibb equilibrium chemic thermodynam count number particl introduc associ chemic potenti lead concept chemic energi n becom part total intern energi chang gibb fundament thermodynam relat howev pure thermomechan descript particl system two fundament form energi name mechan work heat gibb emerg concept follow perspect present altern general gibb formal serv statist theori emerg chemic potenti introduc level individu meso even microst system research practic biophys chemistri sinc epitom perspect concept potenti mean forc condit free energi play central role theori suggest general energet represent scientif data form count frequenc measur routin equilibrium constant chemistri laboratori
D013816
T090
36,301,086
epidemiolog link antimicrobi resist clinic salmonella enterica st isol nationwid microbi popul genom studi switzerland salmonella lead caus foodborn outbreak system infect worldwid emerg multi drug resist salmonella lineag ciprofloxacin resist subclad cip r within salmonella enterica serovar kentucki st threaten effect prevent treatment infect understand genom divers antimicrobi resist gene content associ kentucki switzerland whole genom sequenc human clinic isol obtain isol belong st cip r high low level ciprofloxacin resist among cip r isol associ variabl mutat ramr acrb combin stabl mutat quinolon resist determin region qrdrs analysi isol patient prolong st colon indic subclon adapt ramr locus mutat hotspot snp analys identifi multipl cluster near ident isol often associ travel includ spatiotempor link isol switzerland largest snp cluster associ travel return indonesia investig global data link addit st salmonellosi isol cluster result emphas urgent need implement whole genom sequenc routin tool salmonella surveil outbreak detect
D019779;D000890
T121;T007
36,301,085
regul dna replic initi para independ par locat bacillus subtili replic segreg genet inform necessari cell prolifer bacillus subtili par system parasoj parbspoj par requir segreg chromosom origin oric region proper control dna replic initi parb bind par site cluster near origin replic assembl slide clamp interact para drive origin segreg diffus ratchet mechan part dynam process parb stimul para atpas activ trigger switch atp bound dimer adp bound monom addit conserv role dna segreg para also regul master dna replic initi protein dnaa hypothes b subtili locat par system proxim oric would necessari para proper regul dnaa test model construct rang genet modifi strain alter number locat par site mani perturb chromosom origin segreg expect contrari hypothesi result show regul dna replic initi para maintain par site separ oric singl par site suffici proper control para result consist model para effici regul parb slide clamp follow load par
D001412;D002876
T026;T007
36,301,081
dissemin metaldehyd catabol pathway driven mobil genet element proteobacteria bioremedi metaldehyd drink water use metaldehyd degrad strain recent emerg promis altern whole genom sequenc use obtain full genom metaldehyd degrad acinetobact calcoaceticus e sphingobium cmet h former genet context metaldehyd degrad gene explor latter none degrad gene identifi calcoaceticus e famili insert sequenc iss found surround metaldehyd degrad gene cluster locat plasmid pame cluster locat close relat plasmid associ ident iss metaldehyd degrad proteobacteria indic horizont gene transfer hgt sphingobium cmet h sequenc analysi suggest phytanoyl coa famili oxygenas metaldehyd degrad gene candid due close homolog previous identifi metaldehyd degrad gene known mahx heterolog gene express escherichia coli alongsid degrad test verifi function signific degrad gene homolog henceforth call mah found mah host within conjug plasmid psm genet context suggest crossov metaldehyd acetoin degrad pathway specif replicon iss respons maintain dispers metaldehyd degrad gene proteobacteria hgt identifi describ addit homolog gene implic first step metaldehyd utilis proteobacteria uncov insight specif step possibl degrad pathway provid
D020560;D042301
T007
36,301,076
pseudomona aeruginosa lasr overexpress lead rsal independ pyocyanin product inhibit low phosphat condit sever pseudomona aeruginosa virul relat trait like pyocyanin regul intric regulatori network call quorum sens qs reli transcript regul activ bind self produc molecul call autoinduc ai qs compos three system las rhl pqs las system regulatori protein lasr interact ai activ two qs system turn rhl pqs system regul express multipl virul relat gene gene reiter operon phzabcdefg phzabcdefg involv pyocyanin product las system also regul negat regul rsal provid negat feedback qs respons includ repress pyocyanin synthesi gene work describ lasr act negat regul phza transcript henc pyocyanin product regul independ rsal activ work contribut understand qs depend pyocyanin product demonstr previous uncharacter role lasr repressor
D011710;D011550
T123;T007;T109
36,301,074
excitatori inhibitori serin bind nmda receptor n methyl aspart receptor nmdar uniqu requir bind two differ neurotransmitt agonist synapt transmiss serin glycin bind one subunit glun glutam bind glun agonist bind receptor bi lobe ligand bind domain lbds close around agonist receptor activ better understand unexplor mechan serin contribut receptor activ perform multi microsecond molecular dynam simul glungluna lbd dimer free serin glutam agonist surpris observ serin bind glun gluna lbds suggest serin compet glutam bind gluna mechan confirm electrophysiolog experi show serin inde inhibitori high concentr although free energi calcul indic serin stabil close gluna lbd inhibitori behavior suggest either remain bound long enough generat suffici forc ion channel gate develop workflow use pathway similar analysi identifi group residu work togeth promot bind conform depend pathway signific impact presenc n link glycan act primarili interact lbd bottom lobe stabil close lbd
D016194;D018698
T123;T121;T116;T192
36,301,070
clinic issu novemb reus singl use bronchoscop key word singl use bronchoscop contamin time limit instruct use ifu endoscop process room workflow key word one room design decontamin sink droplet clean storag transport simethicon use endoscopi key word adenosin triphosph atp test defoam agent water bottl borescop inspect residu implement borescop inspect flexibl endoscop key word visual inspect clean verif high risk endoscop compet verif prepurchas evalu
D004203;D019723
T061;T074
36,301,066
guidelin practic prevent unintent retain surgic item retain surgic item rsis advers event affect patient surgeon nurs interdisciplinari team work standard surgic item account process help periop team member prevent rsis aorn recent revis guidelin prevent unintent retain surgic item provid background inform rsis way prevent revis guidelin describ role team communic coupl specif nurs action aim prevent rsis articl review key concept guidelin discuss new chang recommend regard consist interdisciplinari approach standard count procedur account soft good sharp miscellan item instrument devic fragment explant foam piec reconcil count discrep adjunct technolog educ articl also provid scenario relat implement adjunct technolog prevent rsis periop leader nurs review guidelin entireti appli recommend prevent rsis
D005547
T020;T037;T072
36,301,058
improv periop nurs care transgend gender divers patient ignor stigma discrimin contribut persist well document dispar inequ unit state health care system regard meet need transgend gender divers tgd peopl recent collect understand margin communiti increas along action address health concern nurs want provid high qualiti care patient howev mani nurs may feel anxious uncertain interact tgd peopl lack educ train periop nurs may encount tgd patient famili member clinic set mani reason know provid appropri care includ gender affirm care articl present foundat cultur compet inform tgd peopl health concern face addit provid action communic approach periop nurs employ well organ level strategi implement provid welcom support affirm environ
D063106
T098
36,301,057
strategi safe maintain surgic volum covid pandem mix method studi resum elect surgeri cancel covid pandem necessit chang preprocedur patient prepar pediatr tertiari care center middl tennesse conduct prospect observ mix method studi determin effect preprocedur covid test team prevent covid relat cancel among pediatr patient receiv plan anesthesia intervent involv famili member patient educ chang health record report includ covid test result team task follow review test result consult famili coordin administr rapid test necessari compar preimplement postimplement cancel rate four procedur area found signific differ cancel reschedul rate p confid interv team base intervent associ preserv low procedur cancel rate mitig barrier preprocedur test
D000086382
T047;T067
36,301,050
regulatori mechan snap associ insulin releas reveal live cell confoc singl molecul local imag impair insulin releas key featur type diabet insulin secret main mediat snare protein close relat blood glucos level howev mechan under glucos control snare protein regul insulin releas larg unexplain herein investig effect glucos subcellular local spatial distribut plasma membran pm snare snap stx use live cell confoc microscop singl molecul local imag techniqu live cell confoc dstorm imag first reveal snap most local pm cluster basal glucos concentr condit demonstr signific coloc stx cluster furthermor data show elev glucos concentr increas express snap induc larger snap cluster pm wherea glucotox sever inhibit snap transport pm caus fewer smaller snap cluster pm addit found glucotox also inhibitori effect coloc snap stx indic decreas interact studi shed light regulatori effect glucos function organ snare subcellular molecular level thus provid new insight mechan snare regul insulin releas
D007328;D003924
T125;T121;T047;T116
36,301,047
virtual group activ new platform social children pediatr cancer case seri covid pandem social peer essenti develop yet reduc children adolesc undergo cancer treatment provid opportun social experi key role provid work pediatr oncolog set tradit person social activ signific impact coronavirus diseas restrict psychosoci provid forc adapt practic case seri illustr four uniqu scenario highlight virtual social interact feasibl benefici virtual social group intend temporari experi describ suggest ongo video base option social activ like prudent pediatr popul
D000086382;D009369
T047;T191;T067
36,301,046
comparison sodium bicarbon lactat ringer hydrat high dose methotrex chemotherapi children high dose methotrex part treatment pediatr cancer reduc risk toxic support measur includ hydrat alkalin recommend institut switch intraven sodium bicarbon lactat ringer worldwid shortag
D008727;D017693
T121;T109
36,301,041
dexamethason potassium canreno allevi hyperalgesia competit regul il jakstat signal pathway inflammatori pain vivo vitro dexamethason dexa potassium canreno cane modul nocicept behavior via glucocorticoid receptor gr mineralocorticoid receptor mr two mechan genom nongenom pathway studi design investig dexa cane mediat nongenom genom effect mechan nocicept inflamm induc chang interleukin il mediat signal pathway rat
D002191;D006930
T121;T184;T109
36,301,040
symptomatolog prognosi clinic find monkeypox infect patient covid era systemat review recent outbreak human monkeypox mpxv nonendem region world great concern
D000086382;D045908
T047;T067
36,301,039
role hmgbragetlr signal pathway cigarett smoke induc inflamm chronic obstruct pulmonari diseas chronic obstruct pulmonari diseas copd common chronic respiratori diseas irrevers continu progress becom fifth burdensom diseas third dead diseas global therefor prevent treatment copd urgent also import clarifi pathogenesi smoke main common risk factor copd cigarett smoke cs caus lung inflamm patholog mechan airway lung tissu airway inflamm one import mechan lead pathogenesi copd recent studi shown high mobil group box hmgb involv occurr develop respiratori diseas includ copd hmgb typic damag associ molecular pattern damp protein main exert activ bind receptor advanc glycat end product rage toll like receptor tlr particip process airway inflamm studi shown abnorm express hmgb rage tlr relat inflamm copd herein discuss role hmgb rage tlr cscigarett smoke extract induc inflamm copd provid new target diagnosi treatment prevent copd
D024243;D000073865;D029424
T123;T047;T116;T055
36,301,038
klf posit regul trim inhibit abnorm synovi fibroblast prolifer migrat well inflamm rheumatoid arthriti rheumatoid arthriti ra caus irrevers joint injuri serious disabl studi aim investig trim regul klf affect aggress behavior synovi fibroblast induc tumor necrosi factor tnf
D000070918;D001172
T047;T025
36,301,037
associ asthma herp zoster role vaccin literatur review herp zoster hz reactiv previous infect varicella zoster virus vzv share mode transmiss hz present pain erythemat vesicl dermatom character burn sensat rash condit suppress cellular immun exampl diabet mellitus chronic obstruct pulmonari diseas asthma cardiovascular diseas chronic steroid use malign etc caus reactiv virus impair immun respons asthma patient either age group may increas suscept hz infect owe skew thth immun result predomin th condit unwarr th cell respons respiratori allergen similar mani studi delin associ asthma hz howev relat steroid use asthma hz uncertain immunosuppress effect might respons increas suscept infect hz increas econom burden morbid prevent use vaccin two type food drug administr fda approv vaccin avail hsv one given singl dose vaccin call zostavax peopl year efficaci fall rd dose subsequ th dose also contraind human immunodefici virusacquir immunodefici syndrom pregnanc peopl take immunosuppress drug shingrix prefer fda two dose vaccin given month apart peopl year immunocompromis peopl henc proper counsel educ risk herp inform patient time util vaccin
D006562;D053061;D001249
T129;T047;T121
36,301,036
n polyunsatur fatti acid improv depress like behavior inhibit hippocamp neuroinflamm mice via reduc tlr express n polyunsatur fatti acid pufa believ implic pathogenesi mani inflamm relat diseas includ depress
D051197;D015525
T123;T121;T116;T109;T192
36,301,035
impact epstein barr virus latent membran protein product b cell activ factor tumor necrosi factor famili baff april receptor epstein barr virus ebv establish lifelong infect human b cell virus consist express latent membran protein lmpa promot b cell surviv prior studi indic lmpa may increas product pro surviv factor b cell activ factor tumor necrosi factor famili baff could also indirect increas b cell surviv current studi sought extend find determin lmpa increas baff product andor respons lmpa express cell cytokin
D020031;D016393
T047;T191
36,301,034
upregul microrna suppress express gipc system lupus erythematosus neuropsychiatr system lupus erythematosus system lupus erythematosus sle especi neuropsychiatr sle npsle complex system autoimmun diseas character variabl cours multipl organ dysfunct studi aim identifi crucial microrna mirna sle npsle
D020945;D035683;D008180
T123;T047;T114
36,301,033
microrna p target creb modul apoptosi cardiomyocyt hypoxiareperfus induc injuri myocardi ischemia reperfus injuri miri caus reperfus therapi myocardi ischem diseas kind major diseas threaten human health live sever lack effect therapeut measur miri microrna mirna abund mammalian speci play critic role initi promot progress miri howev biolog role molecular mechan mirna miri entir clear
D015428;D035683
T123;T046;T114
36,301,032
short term clinic observ belimumab treatment recent diagnos system lupus erythematosus explor therapeut effect safeti belimumab treatment recent diagnos system lupus erythematosus sle
D007166;D008180
T129;T047;T121
36,301,031
forkhead box recruit foxp treg cell induc immun escap hilar cholangiocarcinoma hilar cholangiocarcinoma hcca malign relat chronic biliari tract inflamm tumor immun escap necessari process tumorigenesi forkhead box foxm could affect progress various carcinoma studi attempt elabor mechan foxm hcca immun escap
D018285;D001650
T191
36,301,030
downregul formyl peptid receptor express epileptogen foci patient focal cortic dysplasia type iib tuber sclerosi complex focal cortic dysplasia type iib fcdiib tuber sclerosi complex tsc show persist neuroinflamm promot epileptogenesi epilepsi progress suggest endogen resolut inflamm inadequ reliev neuron network hyperexcit explor potenti role formyl peptid receptor fpr key regul inflamm resolut epilepsi caus fcdiib tsc examin express cellular distribut fpr
D004827;D054220;D014402
T033;T019;T047;T191
36,301,029
immun cell cebp defici associ hepat mononuclear defect spontan hepat steatohepat induc liver fibrosi ccaatenhanc bind protein cebp transcript factor known involv macrophag differenti function steatohepat liver fibrosi
D005234;D006505
T047
36,301,028
effect regul macrophag polar phenotyp intervertebr disc degener macrophag inflammatori cell penetr close nucleus pulposus polar play import role intervertebr disc degener ivdd paper attempt investig pathogenesi ivdd alter polar state macrophag
D055959
T047;T190
36,301,027
cd effector memori cell respons chlamydia pneumonia stimul peripher blood mononuclear cell nonasthmat subject chlamydia pneumonia c pneumonia gram negat intracellular bacterium caus respiratori infect human includ subject without asthma c pneumonia activ cell eg monocytesmacrophag vitro produc cytokin may contribut inflammatori respons observ asthma immunolog differ exist subject without asthma regard host respons c pneumonia heterogen subsequ divers pathophysiolog asthma better understood analyz repertoir cell subpopul common distinct differ asthma endotyp includ cytokin produc cd cell helper th high vs th low
D016993;D001249
T047;T007
36,301,026
low serum level oh vitamin relat th treg chang colorect cancer patient serum hydroxyvitamin oh level alter colorect cancer crc develop regulatori treg cell helper type th cell involv immun respons th mediat proinflammatori respons contribut tumorigenesi treg play differ role differ period crc vitamin defici associ signific variat peripher immun cell studi investig relationship th treg cell oh level crc
D050378;D015179
T191;T025
36,301,025
exploratori analysi interleukin hospit covid patient major contributor coronavirus diseas covid progress sever dysregul innat adapt immun respons interleukin il il famili member broad anti inflammatori properti thus far littl known role viral infect recent studi shown inconsist result one studi find increas circul il covid patient comparison healthi control wherea two studi report differ il concentr
D000086382;D015843
T123;T121;T116;T067;T047
36,301,024
role inflammatori mirna mrna interact pbmcs colorect cancer obes patient inflamm critic hallmark obes colorect cancer crc studi aim investig effect microrna mirna messeng rna mrna interact inflammatori network involv obes crc
D015179;D035683
T123;T191;T114