PMID
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36.4M
| Title/Abstract
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36,299,184
|
hepatocellular carcinoma immun microenviron tumor immun microenviron time play crucial role growth progress therapeut respons hepatocellular carcinoma hcc prototyp inflamm associ cancer efficaci immunotherapi larg depend time target immun microenviron attract strategi treatment hcc review provid characterist immun microenviron hcc therapeut approach base immun microenviron inform immun microenviron under respons resist hcc immunotherapi
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D006528;D008113
|
T191
|
36,299,183
|
tumor vaccin realli cure liver cancer china incid liver cancer remain high approxim diagnos patient intermedi advanc stage high recurr rate poor prognosi surgeri therefor substanti reduc incid mortal alway major clinic challeng liver cancer recent year immun checkpoint inhibitor therapi repres program death protein pd antibodi gradual innov tradit paradigm tumor treatment beneficiari popul liver cancer patient relat limit rapid develop high throughput sequenc proteom immunom field demand precis medicin continu increas tumor vaccin especi deriv neoantigen shown promis therapeut effect malign solid tumor melanoma non small cell lung cancer due immunogen combin latest research report home abroad paper emphasi whether tumor vaccin effect treat even cure liver cancer
|
D019496;D002289;D008175;D008113
|
T129;T121;T191;T116
|
36,299,182
|
companion diagnost target therapi immunotherapi hepatocellular carcinoma hepatocellular carcinoma hcc high incid low five year surviv rate china lack effect therapeut approach avail unresect patient advanc hcc recent develop target immunotherapi agent applic therapi various solid tumor brought new option benefit patient advanc hcc companion diagnost cdx emerg develop target agent role select elig patient specif targetedimmunotherapi agent improv prognosi get promin articl focus cdx technolog applic relat hcc target immunotherapi order provid inspir precis diagnosi treatment hcc
|
D006528;D008113;D000970
|
T121;T191;T109
|
36,299,181
|
advanc target immun therapi hepatocellular carcinoma target immunotherapi drug hepatocellular carcinoma hcc rapid develop atezolizumab combin bevacizumab recommend first line standard care unresect advanc hcc sever nation intern guidelin combin therapi sindilizumab bevacizumab biosimilar apatinib carrilizumab dulvalizumab tremelimumab also recommend first line standard regimen advanc hcc guidelin chines societi clinic oncolog local therapi combin target drug sorafenib lenvatinib immun checkpoint inhibitor signific improv outcom therefor progress also made studi singl agent combin regimen periop neoadjuv therapi
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D006528;D008113;D059451
|
T121;T191
|
36,299,180
|
analyz obes indic effect fertil preserv treatment patient endometri atyp hyperplasia earli endometri cancer object investig clinic featur obes indic patient endometri atyp hyperplasia eah earli endometri cancer ec analyz relationship index effect fertil preserv therapi method clinic data patient eah ec endometri benign lesion treat peke univers peopl hospit januari june requir fertil spare treatment collect obes indic calcul analyz retrospect result obes indic obes bodi mass index bmi kgm rate patient fertil preserv treatment abdomin obes waist circumfer wc cm rate obes indic bmi wc waist hip ratio whr weight height ratio whtr bodi round index bri lipid accumul index lap viscer adipos index vai higher endometri benign lesion p relat factor affect efficaci fertil preserv treatment predict valu ec higher bmi wc whr whtr bri risk factor lower complet remiss rate nine month treatment p predict valu bri whtr combin patholog type superior indic area curv auc auc relat obes indic glucolipid indic bmi wc whr whtr bri lap vai posit correl homeostasi model assess insulin resist index glycosyl hemoglobin triacylglycerol p vai negat correl high densiti lipoprotein cholesterol p conclus patient eah ec treat fertil preserv therapi abnorm obes index affect treatment effect bri whtr combin patholog good predict valu effect fertil preserv treatment clinic practic appropri indic could select evalu bodi shape glucolipid metabol predict efficaci
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D059247;D004714;D016889
|
T061;T047;T191
|
36,299,179
|
effect time recombin lutein hormon supplement pregnanc outcom women advanc reproduct age follicular phase long protocol object investig effect supplement recombin lutein hormon rlh time pregnanc outcom patient year older follicular phase long protocol method clinic data women undergo vitro fertil intracytoplasm sperm inject follicular phase long protocol collect retrospect analyz first affili hospit nanj medic univers januari decemb patient year older includ studi divid three group group patient recombin follicl stimul hormon rfsh stimul cycl group b patient rfsh plus rlh supplement mid follicular phase cycl patient group c receiv combin rfsh rlh first day ovarian stimul cycl basic characterist patient group observ effect ovarian simul pregnanc outcom compar among three group logist regress model perform explor associ differ group pregnanc outcom result basic characterist age durat infertil bodi mass index bmi serum basic follicl stimul hormon fsh compar among three group p anti mllerian hormon amh antral follicl count afc basic lutein hormon lh signific lower group c compar group group b p statist signific differ initi dosag total dosag durat gonadotropin gn among three group p initi dosag total dosag durat gn higher group c two group number oocyt retriev avail embryo signific lower group b group c group p adjust age bmi amh afc basic fsh lh total gn dosag endometri thick transfer number oocyt retriev number embryo transfer stage embryo transfer fresh embryo transfer cycl clinic pregnanc rate adjust ci p conclus supplement rlh first day ovarian stimul improv pregnanc outcom patient year older fresh embryo transfer cycl follicular phase long protocol howev supplement rlh benefit cumul live birth rate
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D011256;D054304
|
T033;T121;T116;T125
|
36,299,178
|
analysi long term outcom differ secondari surgeri recurr stress urinari incontin burch colposuspens object analyz long term outcom differ secondari surgeri women recurr stress urinari incontin sui burch colposuspens method februari februari five women recurr sui burch colposuspens peke union medic colleg hospit retrospect follow long term outcom secondari surgeri analyz subject cure burch colposuspens secondari surgeri assess patient self report incontin symptom patient global impress improv questionnair object cure improv failur determin hour pad test result three women underw tension free vagin tape retropub tvt secondari surgeri one underw tension free vagin tape obtur tvt one underw singl incis tension free vagin tape secur tvt secur follow period five women year rang year three women undergo tvt secondari surgeri subject cure two women undergo tvt tvt secur subject cure woman undergo tvt object improv conclus feasibl women recurr sui burch colposuspens receiv secondari surgeri limit data suggest tvt could consid
|
D014550;D053825;D014549
|
T047;T074;T046
|
36,299,177
|
clinic studi hysteroscop electroresect figo type myoma object analyz clinic applic evalu effici hysteroscop electroresect intern feder gynecolog obstetr figo type myoma method clinic data patient underw hysteroscop electroresect singl figo type myoma obstetr gynecolog hospit fudan univers januari octob collect retrospect clinic symptom myoma size locat oper time intraop bleed surgic complic postop follow record subsequ pregnanc outcom follow result total patient figo type myoma includ studi averag age year old diamet myoma cm rang cm rate complet resect myoma one oper averag oper time minut rang minut averag intraop bleed ml rang ml complic uterin perfor massiv hemorrhag hyperhyder syndrom infect occur patient perioper case signific increas menstruat oper cure rate effect rate hysteroscop electroresect figo type myoma patient fertil requir averag follow time month pregnanc rate within year oper averag postop pregnanc time month case complet deliveri oper includ case vagin deliveri case cesarean section none uterin ruptur conclus hysteroscopi could effect resect figo type myoma hysteroscop electroresect figo type myoma minim invas rapid postop recoveri could achiev pregnanc short time help reduc amount menstruat also benefici prognosi fertil carri experienc hysteroscopist
|
D007889;D014594;D009214
|
T191
|
36,299,176
|
comparison four coagul test valu normal pregnant women earli late pregnanc influenc age object explor compar refer rang four coagul test normal pregnant women earli late pregnanc influenc age method valu four coagul test pregnant women gave singl birth peke univers first hospit obstetr gynecolog hospit fudan univers west china second univers hospit peke univers third hospit shengj hospit china medic univers februari juli measur analyz studi includ prothrombin time pt activ partial thromboplastin time aptt fibrinogen fib thrombin time tt four normal refer rang coagul earli late pregnanc phase express p p differ two pregnanc phase compar non parametr test two relat sampl differ pregnant women advanc non advanc age pregnanc phase compar independ sampl non parametr test chi squar test use compar incid pregnanc complic differ coagul refer rang result refer rang pt normal pregnant women earli late pregnanc refer rang aptt refer rang fib gl gl refer rang tt compar earli pregnanc pt aptt tt shorten signific fib signific increas late pregnanc p pt aptt tt advanc non advanc age pregnant women signific differ p incid fetal distress higher incid preterm birth lower refer rang pt late pregnanc incid gestat diabet mellitus higher earli late gestat fib refer rang incid hypertens disord pregnanc higher late gestat fib refer rang p conclus coagul function pregnant women increas signific growth pregnanc signific differ advanc signific non advanc age pregnant women recommend rang normal pregnant women earli late pregnanc pt recommend rang aptt recommend rang tt appropri rang normal pregnant women earli late pregnanc fib still need explor
|
D037841;D047928
|
T098;T046
|
36,299,175
|
fertil protect preserv patient endometriosi chines consensus
|
D004715;D059247
|
T061;T047;T191
|
36,299,174
|
clinic manag guidelin fetal congenit diaphragmat hernia cdhcdhcdh
|
D065630
|
T019
|
36,299,173
|
year old woman achondroplasia quadriparesi ovarian cyst erron diagnos urinari retent autom bladder scan background autom bladder scan becom princip tool assess manag chronic debilit patient resid skill nurs facil hospic acut inpati set larg extent bladder scan general perform nurs staff replac physic examin address differenti diagnos anuria void disturb requir consider urinari catheter health care provid quick master easili perform techniqu current due confid bladder scan find physic examin suprapub palpat percuss may careless omit case descript present illustr perform physic examin lead misdiagnosi caus misinterpret bladder scan find case report year old quadriparet chronic ventil femal patient achondroplasia underw repeat hospit referr bladder catheter presum flaccid neurogen bladder urinari retent postul diagnosi base occasion report urinari cathet obstruct well autom bladder scan indic mark distend bladder howev bladder could drain insert urinari cathet eventu proper physic examin exclud presenc suprapub full compat distend bladder contradict bladder scan find prompt examin overlook evalu comput tomographi report huge ovarian cyst patient found intact void capabl wean cathet conclus case literatur review underscor drawback autom bladder scan techniqu use adjunct measur rather replac physic examin evalu void disturb especi discrep bladder scan find volum urin drain catheter
|
D016055;D000130;D010048
|
T033;T019;T047
|
36,299,172
|
retrospect studi singl center poland postop outcom muscl strength patient surgic sutur achill tendon use kessler sutur week supervis postop physiotherapi background retrospect studi singl center poland aim evalu effect supervis physiotherapi svph visit relat peak torqu rpt relat isometr torqu rit foot plantar flexion muscl fpfm foot dorsiflexion muscl fdfm frequenc visit per week conduct week surgic sutur achill tendon use kessler sutur atssk hypothes higher number frequenc intens supervis physiotherapi visit hnfisvphv would correl signific improv rit rpt fpfm materi method group includ patient x visit atssk one svph protocol divid subgroup hnfisvphv x lower number frequenc intens svph visit lnfisvphv x twenti particip without achill tendon ruptur includ group b control group tegner activ scale underw rit rpt limb symmetri index lsi measur use biodex medic system result fpfm rit signific lower oper limb group non oper limb group b p hnfisvphv correl higher fpfm rit lsi oper limb r p r p hnfisvphv obtain higher lsi fpfm rpt p p lnfisvphv conclus svph visit atssk week insuffici obtain equal valu rit fpfm fdfm hnfisvphv correl higher rit valu consider improv rit rpt fpfm compar lnfisvphv
|
D000125
|
T023
|
36,299,164
|
earli resum continu ambulatori periton dialysi follow day surgeri pleuroperiton communic report case year old man introduc continu ambulatori periton dialysi capd chronic renal failur five month later point massiv right pleural effus diagnos pleuroperiton communic refer depart surgeri dialysi fluid indocyanin green inject periton cathet capd minut surgeri small fistula detect press abdomen use infrar thoracoscopi fistula sutur cover polyglycol acid sheet fibrin glue day surgeri capd resum discharg post oper sixth day without complic
|
D005402;D006876;D007676;D010531;D010532;D010995
|
T061;T047;T190
|
36,299,163
|
primari pericardi malign mesothelioma report case year old woman refer hospit cough fever chest comput tomographi ct show mass show slight enhanc effect pericardium fdg pet show accumul fdg mass thoracoscop surgic biopsi perform establish diagnosi histolog studi show prolifer short spindl shape cell surround lymphocyt spindl cell immunohistochem posit cytokeratin aeae wt cam intelectin negat cea ttf napsin claudin calretinin muc pax cd find compat epitheli pericardi malign mesothelioma
|
D000086002;D008654;D008175;D006338;D008479;D013953
|
T047;T191
|
36,299,162
|
primari myelolipoma posterior mediastinum report case patient year old male comput tomographi ct scan reveal tumor posterior mediastinum year grew slowli mm longest diamet coron slice thoracoscop surgeri perform resect patholog examin reveal predomin matur adipos tissu hematopoiet tissu hematoxylin eosin stain hematopoiet tissu compris matur erythroblast megakaryocyt granulocyt immun stain diagnos myelolipoma incid myelolipoma origin besid adren gland report far search case myelolipoma posterior mediastinum literatur
|
D018209;D000310
|
T191
|
36,299,161
|
multipl papillari fibroelastoma requir differenti infecti endocard report case year old woman sever oscil intracardiac mass aortic valv admit fever subacut brain infarct suggest infecti endocard ie empir antibiot treatment four week accord guidelin ie cardiac mass remain valv howev blood cultur test negat find support initi diagnosi ie fact suggest ie unlik patient underw tumor resect cardiopulmonari bypass prevent repeat embol obtain definit diagnosi intraop oscil mass appear primari cardiac tumor resect non coronari cusp commissur right non coronari cusp patholog diagnosi papillari fibroelastoma current patient free recurr
|
D000084122;D005350;D006338;D004696
|
T047;T191
|
36,299,160
|
cardiac metastasi colorect cancer discov due palpit dyspnea report case year old woman present hospit complaint palpit dyspnea complet atrioventricular block tumor fill right atrium detect comput tomographi ct echocardiographi sinc symptom sever risk sudden death due pulmonari embol tumor resect perform patholog result suggest tumor well differenti metastat adenocarcinoma origin colorect cancer sinc tumor could complet remov radiat therapi perform oper cardiac metastas colorect cancer relat rare occasion seen autopsi case infrequ surviv case regular follow therefor requir
|
D006338;D011655;D015179
|
T047;T191;T046
|
36,299,159
|
success pulmonari embolectomi use bronchoscop report case surgic pulmonari embolectomi indic acut massiv pulmonari thromboembol complic float thrombi right heart system postop residu thrombi associ persist pulmonari hypertens subsequ right heart failur result poor surgic outcom year old man admit institut owe dyspnea exert transthorac echocardiographi reveal float right atrial mass right ventricular overload addit enhanc comput tomographi ct show right atrial mass well bilater massiv pulmonari embol perform urgent pulmonari embolectomi use bronchoscop adjunct angioscop complet remov peripher thrombi prevent serious complic endobronchi hemorrhag due pulmonari arteri injuri clear bloodless view peripher pulmonari arteri obtain use short intermitt circulatori arrest techniqu postop cours unev discharg ambulatori day surgeri without symptom
|
D011655;D013927
|
T047;T046
|
36,299,158
|
transient left ventricular dysfunct giant coronari aneurysm resect repair coronari arterioven fistula coronari arteri bypass graft report case coronari arteri aneurysm coronari arterioven fistula relat rare clinic set report surgic case year old male giant coronari arteri aneurysm find coronari arterioven fistula comput tomographi ct perform complet aneurysm excis coronari arteri bypass graft left intern thorac arteri posterolater branch fistula locat giant aneurysm circumflex arteri coronari vein close coronari sinus close aneurysm sac postop ct found residu aneurysm fistula howev great cardiac vein thrombos imped venous flow thrombus seem reduc left ventricular eject fraction lvef four month oper lvef improv preoper level
|
D003323;D001164;D003324;D018487
|
T047;T046;T190
|
36,299,157
|
giant anastomot aneurysm associ albuminglutaraldehyd sealant late complic acut aortic dissect surgeri report case year old woman taken hospit chief complaint chest back pain diagnos stanford type acut aortic dissect underw ascend aortic replac fifteen month surgeri giant anastomot aneurysm found proxim distal anastomos chest comput tomographi ct reoper indic follow sternal entri anastomot dehisc found bioglu albuminglutaraldehyd sealant appli previous surgeri caus aneurysm sever postop adhes preclud extens surgeri redo replac ascend aorta carri histopatholog examin reveal extens necrosi smooth muscl cell aortic wall anastomot site mark inflammatori cell infiltr around aortic wall artifici graft associ bioglu use suggest use appropri tissu adhes reinforc dissect aortic wall import well care long term follow
|
D001014;D019917;D014014;D000784;D017545
|
T061;T047;T122;T046
|
36,299,156
|
giant right coronari arteri pseudoaneurysm report case giant coronari arteri aneurysm rare clear consensus regard treatment herein report case unusu entiti patient year old man follow coronari angiographi show leakag contrast agent one posterior descend pd branch right coronari arteri enhanc comput tomographi ect reveal giant pseudoaneurysm maximum diamet mm percutan balloon angioplasti perform vessel angina pectori year earlier exclud pseudoaneurysm arteri perfus close wall defect culprit branch cardiopulmonari bypass need revascular anoth pd branch nearbi advers event observ surgeri postop ect scan confirm aneurysm complet thrombos leakag
|
D017541;D003323
|
T047;T046
|
36,299,155
|
intern hernia accompani intestin necrosi aortic arch replac report case year old man thorac aortic aneurysm admit hospit aortic arch replac perform unev suffer abdomin pain day oper comput tomographi ct scan reveal strangul bowel obstruct perform emerg open abdomin surgeri oper found adhes greater omentum retroperitoneum small intestin intussuscept site strangul necrosi cm length perform partial resect small intestin encount rare strangul bowel obstruct open heart surgeri due adhes great omentum patient without histori abdomin surgeri
|
D001013;D007415
|
T023;T047
|
36,299,154
|
earli structur valv deterior aortic valv replac extern mount bioprosthet valv trifecta report two case trifecta valv made singl bovin pericardi sheet extern mount titanium stent valv design provid good hemodynam perform wide effect orific area howev report earli structur valv dysfunct caus acut heart failur case year old man undergon aortic valv replac avr use trifecta mm five year ago present fever diastol murmur echocardiographi show prosthet valv regurgit patient later develop prosthet valv endocard case year old woman undergon avr use trifecta gt mm two year ago develop sudden chest pain dyspnea prosthet valv regurgit patient underw avr new bioprosthet valv via sternotomi larg tear found right coronari cusp trifecta case trifecta accomod avoid overs check posit coronari ostia sinus valsalva secur late outcom trifecta gt remain unproven use still need caution
|
D006350;D001705;D001022;D019918;D004697;D001024
|
T061;T047;T074
|
36,299,153
|
acut aortic dissect rapid enlarg aneurysm methicillin resist staphylococcus aureus bacteremia patient year old man refer hospit nearbi clinic complaint chest back pain urgent admit diagnosi stanford type debakey typebr acut aortic dissect cours treatment develop urinari tract infect caus methicillin resist staphylococcus aureus mrsa thereaft patient develop bacteremia follow comput tomographi ct show rapid enlarg descend aortic aneurysm left extern iliac arteri eia aneurysm day admiss thorac endovascular aortic repair left eia resect right eia left femor arteri bypass perform howev contrast enhanc ct scan day hospit reveal type ia endoleak enlarg descend aortic aneurysm patient underw replac descend aorta day postop patient need time recoveri discharg day three year discharg recurr infect patient visit outpati clinic report case acut aortic dissect rapid enlarg aneurysm mrsa bacteremia serious condit succes cure continu antibiot treatment two surgic resect revascular
|
D055624;D019917;D000784;D016470;D001014;D017545
|
T061;T047;T007;T046
|
36,299,152
|
vascular prosthesi perfor caus stent graft insert innomin arteri total aortic arch replac patient year old woman underw thoracoabdomin aorta replac type b aortic dissect three year ago aortic root replac total aortic arch replac due asymptomat type aortic dissect two year previous clinic cours unev follow comput tomographi ct disclos anastomot insuffici innomin arteri left main coronari arteri stenosi owe hematoma emerg percutan coronari intervent stent graft insert innomin arteri perform success seven month later howev ct scan reveal perfor posterior wall artifici graft damag edg implant stent graft patient underw open surgeri perfor artifici graft sutur redund stent graft edg resect artifici graft damag stent graft placement rare date may increas futur accord broader applic endovascular treatment
|
D019917;D000784;D017545;D057510
|
T061;T047;T046
|
36,299,151
|
midterm outcom pulmonari valv leaflet augment use fresh autolog pericardium transannular patch repair tetralog fallot although valv spare vs patient smaller pulmonari valv increas transannular patch repair tap account half total tetralog fallot correct worldwid use fresh autolog pericardi patch perform modifi tap procedur pulmonari valv leaflet augment propos sung et al aim explor earli midterm outcom procedur
|
D011664;D013771;D006348;D011665
|
T061;T019;T023;T046
|
36,299,136
|
mach zehnder interferomet base integr photon aceton sensor approach sub ppm level detect limit detect aceton gaseous form exhal breath use integr sensor provid effect tool diseas diagnost aceton marker monitor human metabol chip aceton gas sensor base principl mach zehnder interferomet propos demonstr sens arm devic activ composit film polyethyleneimin amido graphen oxid gas sensit adsorpt layer composit film demonstr good select aceton gas use repeat stabl long term use room temperatur oper demonstr sensor high sensit ppm aceton environ detect limit reach ppm make feasibl use clinic diagnosi diabet prognosi heart failur
|
D000096;D015374
|
T121;T059;T075;T109
|
36,299,102
|
led base larg field view axi quantit phase contrast microscopi hologram multiplex manuscript describ develop singl shot self referenc wavefront divis multiplex digit holograph microscop employ led sourc larg field view quantit phase imag biolog sampl address difficulti aris perform interferometri low tempor coher sourc optic arrang util multipl fresnel biprism use hologram multiplex enhanc field view increas signal nois ratio biprism offer eas obtain interfer pattern automat match path length two axi beam use low tempor coher sourc reduc speckl nois cost form factor setup develop techniqu implement use visibl uv led test polystyren microspher human erythrocyt
|
D011137;D006696
|
T060;T122;T109
|
36,299,095
|
local aberr control improv effici multiphoton holograph project optic aberr affect qualiti light propag turbid medium refract index spatial inhomogen multiphoton optic applic two photon excit fluoresc imag optogenet aberr non linear impair effici excit demonstr sensorless adapt optic techniqu compens aberr hologram project turbid media use spatial light modul project custom three dimension holograph pattern correct local anisoplanat distort method test synthet biolog sampl counteract aberr aris respect misalign optic system sampl inhomogen case anisoplanat correct improv intens stimul pattern least two fold
|
D006696;D055096
|
T060;T073
|
36,299,090
|
scc fret singl cell base calibr fret system reliabl measur calibr paramet crucial quantit three cube frster reson energi transfer fret measur develop singl cell base calibr method scc fret simultan obtain spectral crosstalk correct paramet calibr paramet g k quantit fret system imag cell express one kind standard fret plasmid known fret effici e donor acceptor concentr ratio rc perform scc fret method three cube fret microscopi cell express cv obtain g k paramet use measur e rc valu cv cv construct live cell obtain ecv ecv rcv rcv consist report valu demonstr effect scc fret method also perform scc fret method cell differ sn level sn sn sn respect obtain consist system calibr paramet differ sn level indic excel robust scc fret requir imag cell express one kind standard fret plasmid measur calibr paramet ident imag condit render scc fret method extrem conveni accur robust scc fret provid strong support expand biolog applic quantit fret analysi live cell
|
D031541;D008853
|
T059
|
36,298,994
|
neural distort field spatial calibr wide field view near eye display propos spatial calibr method wide field view fov near eye display ned complex imag distort imag distort ned destroy realiti virtual object caus sick achiev distort free imag ned necessari establish pixel pixel correspond viewpoint display imag design compact wide fov ned requir complex optic design design display imag subject gaze conting non linear geometr distort explicit geometr model difficult repres comput intens optim solv problem propos neural distort field ndf fulli connect deep neural network implicit repres display surfac complexli distort space ndf take spatial posit gaze direct input output display pixel coordin intens perceiv input gaze direct synthes distort map novel viewpoint queri point ray viewpoint comput weight sum project output display coordin imag experi show ndf calibr augment realiti ned fov pixel arcmin median error use train viewpoint addit confirm ndf calibr accur non linear polynomi fit especi around center fov
|
D000465
|
T170
|
36,298,966
|
compact multicolor two photon fluoresc microscopi enabl tailor continuum generat self phase modul dispers wave generat precis manag fiber optic nonlinear anomal dispers demonstr control generat plural optic cycl puls base mhz chromium forsterit laser allow multicolor two photon tissu imag wavelength mix format high order soliton effici coupl dispers wave generat lead phase match spectral broaden obtain broadband continuum rang nm nm deliv nj puls puls width fs use piec larg mode area fiber locat spectral enhanc around nm two photon excit green fluorophor easili compress result puls close limit durat without need activ puls shape optim wavelength mix sum frequenc excit realiz manag power ratio group delay soliton dispers wave vari initi puls energi without addit delay control thus demonstr simultan three color two photon tissu imag contrast manag differ signal sourc optim lead effici two photon excit reach imag depth low mw illumin power believ sourc develop lead effici compact approach drive multicolor two photon fluoresc microscopi ultrafast investig strong field driven applic
|
D017785;D002857
|
T131;T196;T167
|
36,298,964
|
microl neural probe effect vivo optogenet stimul microl probe enabl optogenet control neural activ spatial separ brain region understand heat generat characterist import studi investig temperatur rise characterist brain tissu use microl probe strong depend surround environ probe includ differ air brain area touch brain tissu anim experi suggest situ temperatur monitor method use temperatur depend electr characterist microl final optic stimul microl prove effect control optogenet neural activ anim model
|
D062308;D001921
|
T063;T023
|
36,298,963
|
plasmon photon biosensor situ detect quantif sar cov particl conceptu numer investig photon crystal fiber pcf base surfac plasmon reson spr sensor rapid detect quantif novel coronavirus plasmon gold base optic sensor permit three differ way quantifi virus concentr insid patient bodi base differ ligand analyt conjug pair photon biosensor demonstr viabl detect sar cov spike receptor bind domain rbd mutat viral singl strand ribonucl acid rna human monoclon antibodi immunoglobulin g igg marquis shape core introduc facilit effici light tailor analyt dissolv steril phosphat buffer salin pbs surfac plasmon metal layer realiz detect pyren butyr acid n hydroxi succinimid ester numer use immobil analyt sens interfac use finit element method fem propos sensor studi critic optim refract index ri rang sinc target analyt ris fluctuat within rang depend sever viral infect polar depend sensor exhibit domin sens attribut x polar mode show averag wavelength sensit nmriu nmriu nmriu analyt spike rbd extract coronavirus rna antibodi igg respect correspond median amplitud sensit riu riu riu respect maximum sensor resolut figur merit found riu riu respect viral rna detect also signific limit detect lod riu nm obtain consid modern bioassay propos compact photon sensor well suit rapid point care covid test
|
D000086382;D015374
|
T075;T047;T059;T067
|
36,298,962
|
quantit protein sens germanium thz antenna manufactur use cmos process develop cmos manufactur thz sens platform could enabl integr state art sens principl mix signal electron ecosystem small footprint low cost devic aim work demonstr label free protein sens platform use high dope germanium plasmon antenna realiz si soi substrat oper thz rang electromagnet spectrum antenna respons differ concentr bsa show case linear respons satur mgml ge antenna soi substrat featur two fold sensit compar convent si substrat reach valu ghz mgml four fold report use metal base metamateri believ result could pave way low cost lab chip biosens platform
|
D005857
|
T196
|
36,298,931
|
high resolut polar sensit fourier ptychographi microscopi use high numer apertur dome illumin polar sensit fourier ptychographi microscopi pfpm allow high resolut imag maintain larg field view without mechan movement optic setup compon contrast ordinari light microscop pfpm provid quantit absorpt phase inform complex birefring specimen high resolut across wide field view use semi spheric home built led illumin array singl polar x na object experiment demonstr high perform pfpm synthes na appli standard quantit method measur half pitch resolut nm achiev usaf resolut test target applic exampl polarimetr properti herbac flower plant metastat carcinoma human liver cell analyz quantit imag
|
D008029;D055096
|
T068;T073
|
36,298,923
|
vde net two stage deep learn method phase unwrap phase unwrap critic step obtain continu phase distribut optic phase measur coher imag techniqu tradit phase unwrap method general low perform due signific nois undersampl paper propos deep convolut neural network dcnn weight jump edg attent mechan name vde net realiz effect robust phase unwrap experiment result reveal weight jump edg attent mechan first propos simpl calcul use phase unwrap propos algorithm outperform network common attent mechan addit unseen wrap phase imag live red blood cell rbc success unwrap train vde net therebi demonstr strong general capabl
|
D000077321
|
T066
|
36,298,907
|
fourier ptychograph microscopi untrain deep neural network prior propos physic assist deep neural network scheme fourier ptychograph microscopi fpm use untrain deep neural network prior fpmup achiev high resolut imag reconstruct multipl low resolut imag unlik tradit train type deep neural network requir larg label dataset propos scheme requir train instead output high resolut imag optim paramet neural network fit experiment measur low resolut imag besid amplitud phase sampl function anoth two parallel neural network generat general pupil function illumin intens factor incorpor care design neural network effect improv imag qualiti robust aberr illumin intens fluctuat present fpm reconstruct use simul experiment dataset demonstr show fpmup scheme better imag qualiti tradit iter algorithm especi phase recoveri expens increas comput cost import found fpmup scheme predict fourier spectrum sampl outsid synthet apertur fpm thus elimin ring effect recov imag due spectral truncat inspir deep imag prior field imag process may imput expans fourier spectrum deep prior root architectur care design four parallel deep neural network envisag resolut fpm enhanc fourier spectrum sampl outsid synthet apertur fpm accur predict
|
D008853;D016571
|
T170;T059
|
36,298,906
|
intellig design chiral metasurfac flexibl target combin deep neural network polici proxim optim algorithm recent deep reinforc learn drl metasurfac design receiv increas attent excel decis make abil complex problem howev time consum numer simul hinder adopt drl base design method appli deep learn base virtual environ proxim polici optim de ppo method design chiral plasmon metasurfac flexibl target model metasurfac design process markov decis process help train well train drl agent design chiral metasurfac exhibit optim absolut circular dichroism valu typic various target wavelength nm nm nm nm great time effici besid train process ppo agent except fast help deep neural network dnn auxiliari virtual environ also method chang variabl paramet nanostructur simultan reduc size action vector thus output size dnn propos approach could find applic effici intellig design nanophoton devic
|
D016571;D000465
|
T170
|
36,298,902
|
hand gestur recognit video taken lensless camera lensless camera imag system use mask place len make thinner lighter less expens lens camera howev addit complex comput time requir imag reconstruct work propos deep learn model name rawdnet recogn hand gestur direct raw video captur lensless camera without need imag restor addit conserv comput resourc reconstruct free method provid privaci protect rawdnet novel end end deep neural network model recognit hand gestur lensless imag system creat specif raw video captur lensless camera abil proper extract combin tempor spatial featur network compos two stage spatial featur extractor sfe enhanc spatial featur frame prior tempor convolut resnet implement spatial tempor convolut video stream propos model achiev accuraci cambridg hand gestur dataset lensless optic experi compar lens camera result addit feasibl physic object recognit assess show recognit achiev respect accuraci use tini portion origin raw data indic potenti reduc data traffic cloud comput scenario
|
D005868;D010363
|
T041;T054
|
36,298,895
|
address imag limit microspher assist nanoscop past decad microspher assist nanoscopi develop rapid overcom diffract limit howev due limit size high surfac curvatur microspher magnifi imag still suffer problem like limit view scope imag distort low contrast paper special imag mechan microspher find irradi key factor microspher imag qualiti util modifi optic tweezer system achiev precis manipul microspher propos high qualiti larg field magnifi imag scheme result show imag area microspher reach minimum identifi featur nm scheme provid new solut extend measur scope microspher assist nanoscop certain promot applic technolog practic
|
D003952;D052898
|
T060;T062
|
36,298,869
|
impact earli pandem sar cov lineag replac variant concern p gamma western bahia brazil correct understand epidemiolog dynam covid caus sar cov essenti formul public polici diseas contain
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,868
|
tumor suppressor p inhibit hepat b virus replic downregul hbx via eap mediat proteasom degrad human hepatocellular carcinoma cell line hbx multifunct regulatori protein play essenti role replic pathogenesi hepat b virus hbv studi found human hepatoma cell tumor suppressor p downregul hbx via ubiquitin depend proteasom degrad p transcript activ result hbv infect essenti effect shown treatment potent p inhibitor pifithrin instead found p facilit bind e associ protein eap e ligas hbx induc eap mediat hbx ubiquitin ternari complex p eap hbx abil p induc eap mediat downregul hbx inhibit hbv replic demonstr vitro hbv infect system studi may provid insight regul hbx hbv replic especi respect p status may also help understand hbv associ tumorigenesi patient
|
D006528;D006509;D008113;D016159
|
T123;T047;T191;T116
|
36,298,867
|
genom epidemiolog reveal circul chikungunya virus eastcentralsouth african lineag tocantin state north brazil chikungunya virus chikv mosquito born virus famili togavirida transmit human aed spp mosquito brazil import case report sinc june two independ introduct one caus asian lineag oiapoqu amap state north region anoth caus eastcentralsouth african ecsa feira de santana bahia state northeast region moreov still limit inform genom epidemiolog chikv surveil studi tocantin state locat northern brazil report increas number chikv case end begin thus better understand dispers dynam viral pathogen state generat near complet chikv genom sequenc four citi obtain clinic sampl result show newli chikv genom tocantin belong ecsa lineag phylogenet reconstruct reveal tocantin strain form singl well support clade appear close relat isol rio grand nort state northeast brazil rio de janeiro state southeast brazil experienc explos ecsa epidem mutat analys show eleven frequent non synonym mutat structur non structur protein indic autochthon transmiss chikv state none genom recov within tocantin sampl carri av mutat e protein associ increas transmiss albopictus studi present highlight import continu genom surveil provid inform record mutat along viral genom molecular surveil tool trace virus spread within countri predict event like occurr new infect contribut improv public health servic
|
D002646;D065632
|
T005;T047
|
36,298,866
|
synergist immunosuppress avian leukosi virus subgroup j infecti bursal diseas virus respons enhanc pathogen recent year superinfect avian leukosi virus subgroup j alv j infecti bursal diseas virus ibdv frequent observ natur led increas virul infect chicken howev reason enhanc pathogen remain unclear studi demonstr effect candid model studi outcom superinfect alv j ibdv cell specif pathogen free spf chick vitro experi found alv j ibdv establish superinfect model synergist promot express il il ifn ifn df cef cell vivo weight loss surviv rate histopatholog observ show sever pathogen present superinfect chicken addit found superinfect alv j ibdv synergist increas viral replic two virus inflammatori mediat secret vitro vivo moreov measur immun organ index blood proport cd cd cd cell result show sever instanc immunosuppress observ superinfect chicken present studi conclud sever immunosuppress induc synergist viral replic alv j ibdv respons enhanc pathogen
|
D001354;D007243;D001353;D015163;D011201
|
T005;T191;T047
|
36,298,865
|
sar cov covid patient republ moldova whole genom sequenc result sinc onset covid pandem viral genom sequenc sever acut respiratori syndrom coronavirus sar cov document republ moldova develop countri geograph locat eastern europ romania ukrain report analysi sar cov sequenc delta omicron variant sar cov case republ moldova obtain august novemb januari may comparison global viral sequenc show among delta variant sar cov ay n follow ay n ay n ay n ay n b n ay n ay n ay n ay n ay n frequent found lineag furthermor lineag omicron variant name ba n follow ba n ba n ba n ba n ba n ba n ba n ba n ba n detect addit also identifi impact militari crisi russia ukrain covid epidemiolog rule collaps distribut delta omicron variant republ moldova addit studi warrant character impact war russia ukrain genom epidemiolog sar cov republ moldova eastern europ
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,864
|
host combat ibdv infect protein rna level infecti bursal diseas ibd acut high contagi immunosuppress avian diseas caus infecti bursal diseas virus ibdv recent year emerg ibdv variant recombin strain ibdv still threaten poultri industri worldwid seem battl host ibdv never end thus urgent develop comprehens effect strategi control diseas better understand mechan under virus host interact would help develop novel vaccin recent much progress made understand host respons ibdv infect battl host ibdv protein level consid front line rna level taken hidden line host combat ibdv infect front hidden line therefor review focus current understand host respons ibdv infect protein rna level
|
D007243;D018175;D011201
|
T005;T047
|
36,298,863
|
revisit papillomavirus taxonomi propos updat current classif line evolutionari evid papillomavirus infect wide array anim host respons rough human cancer compar genom differ virus type belong specif taxonom group eg speci genera potenti illumin physiolog differ virus differ biolog outcom likewis extrapol featur relat virus power requir solid foundat support evolutionari relationship virus current papillomavirus classif system base pairwis sequenc ident howev advent metagenom facilit high throughput sequenc molecular tool enrich circular dna molecul use roll circl amplif dramat increas describ divers viral famili surpris result dramat increas absolut number viral type ie sequenc share lt l gene pairwis ident mani novel virus sole member novel speci within novel genus ie singleton highlight scratch surfac papillomavirus divers discuss increas observ sequenc divers complic papillomavirus classif propos potenti solut issu explicit base speci genera classif evolutionari histori virus base core viral protein e e l papillomavirus strategi mean possibl virus identifi closest neighbor base e e l phylogenet tree closest neighbor base l nucleotid ident case propos virus would consid novel type share less ident closest neighbor e e l phylogenet tree
|
D014780;D030361
|
T005;T047
|
36,298,862
|
phylogenet character hiv sub subtyp karachi pakistan background hiv sub subtyp common part africa russia former soviet union countri eastern europ pakistan sub subtyp predomin hiv subtyp preliminari evid suggest distinct strain hiv sub subtyp circul pakistan howev depth molecular phylogenet character hiv sub subtyp strain pakistan present perform detail character hiv sub subtyp epidem pakistan use state art molecular epidemiolog phylodynam method total hiv sub subtyp gag sequenc includ sequenc generat specif studi plhiv part cohort repres sub subtyp gag sequenc pakistan analyz maximum likelihood phylogenet cluster analysi use determin relationship pakistani sub subtyp strain pandem sub subtyp strain furthermor use signatur variat charg distribut select pressur epitop predict analys character variat uniqu pakistani hiv strain establish associ signatur variat gag epitop profil result hiv sub subtyp sequenc pakistan form three main cluster two cluster kenyan sequenc sequenc respect one form pakistan specif cluster sequenc much less relat sub subtyp sequenc avail databas sequenc pakistan specif cluster kenyan refer strain exhibit sever signatur variat especi amino acid posit structur protein model suggest amino acid chang posit result alter gag protein structur well gag specif cell epitop conclus result suggest major pakistan hiv sub subtyp strain uniqu pakistan specif mutat pattern gag
|
D015497;D015658
|
T005;T047
|
36,298,861
|
genet cross neutral analys coxsackievirus circul taiwan suggest domin genotyp b serv vaccin candid coxsackievirus cva well known caus hand foot mouth diseas hfmd outbreak frequent report taiwan past twenti year epidemiolog genet variat cva taiwan analyz studi cva infect usual occur earli summer earli winter show increas incid taiwan littl cva detect cva infect preval patient year old total isol sequenc phylogenet analysi base vp region show cva subgenotyp b domin isol taiwan b identifi isol collect high frequenc synonym mutat amino acid sequenc vp region among cva isol except posit show posit select recombin analysi whole genom cva isol indic untransl region non structur protein region cva subgenotyp b recombin coxsackievirus cva enterovirus eva genotyp respect recombin pattern subgenotyp b similar b howev region similar eva genotyp b cross neutral among cva show mous antisera various subgenotyp virus cross neutral differ genotyp high neutral antibodi titer result suggest domin cva genotyp b serv vaccin candid cva
|
D006232;D004770;D014612;D029821
|
T129;T121;T116;T005;T047
|
36,298,860
|
divers ecolog caudoviricet phage genom termin repeat fecal metagenom four dutch cohort human gut harbor numer virus infect human host microb inhabit gastrointestin tract virus remain undiscov influenc human health unknown character viral genom gut metagenom data individu four popul patient cohort focus subset virus high abund gut remain larg uncharacter allow confid complet genom identif phage belong class caudoviricet possess genom termin repeat detect speci level unit belong subset complet repres genom major public gut virom databas unit display divers genom featur predict infect wide rang microbi host averag account lt metagenom read analysi longitudin data individu show composit fraction virom remain relat stabl period year also demonstr speci level unit high preval detect gt individu cohort final find associ high preval phage human phenotyp explain relat abund potenti host
|
D001435;D014780
|
T005
|
36,298,859
|
clone exogen express function analysi interferon gadus macrocephalus interferon ifn consid one key molecul regul innat adapt immun function ifn best describ human less ifn fish speci describ protein level present studi ifn gadus macrocephalus gmifn examin term bioinformat prokaryot express yeast express antivir activ immun regulatori function cdna gmifn contain open read frame nucleotid code amino acid matur protein contain nuclear local signal motif obvious ifn signatur sequenc c termin gmifn similar atlant cod homolog less speci gmifn detect gill spleen intestin brain kidney interest earli develop strong signal gmifn detect day post hatch prokaryot express plasmid pet gmifn construct express product bl confirm mass spectrometri meanwhil plasmid pgapza gmifn myc tag construct transmit pichia pastori yeast gs product test use western blot purifi gmifn either bl yeast strong antivirus spring viremia carp virus effect vector pcdna gmifn express epc cell line high transcript level mhc class chain relat protein mica gene detect exogen gm ifn protein could also induc mica express indic gmifn could stimul immun respons yeast gs gm ifn protein inclus bodi given zebrafish oral transcript zebrafish ifn upregul signific howev gene interferon type signal pathway well stimul
|
D007371;D029941
|
T129;T121;T123;T116
|
36,298,858
|
host cell receptor implic cellular tropism bvdv bovin viral diarrhea virus bvdv one hazard virus caus huge econom loss cattl industri around world recent year continu increas divers pestivirus worldwid member genus pestivirus flavivirida famili bvdv wide rang host anim includ cattl goat sheep pig camel cloven hoof anim multi tissu tropism well recognit permiss cell virus via interact cellular receptor prerequisit success infect far littl known cellular receptor essenti bvdv entri detail function bvdv infect thus discoveri cellular receptor involv entri bvdv pestivirus signific develop novel intervent viral envelop glycoprotein e rns e crucial determin cellular tropism bvdv cellular protein bound e rns e potenti particip bvdv entri abund might determin cellular tropism bvdv summar current knowledg regard cellular molecul describ bvdv entri complement regulatori protein cd heparan sulfat hs low densiti lipoprotein ldl receptor disintegrin metalloproteinas adam furthermor focus implic recent identifi cellular receptor pestivirus bvdv life cycl knowledg provid theoret basi bvdv prevent treatment target cellular receptor essenti bvdv infect
|
D001908;D030241;D010576
|
T005
|
36,298,857
|
character grapevin fanleaf virus isol chardonnay vine exhibit sever mild symptom two vineyard fanleaf degener complex viral diseas viti spp detriment impact fruit yield reduc product lifespan vineyard worldwid franc main causal agent grapevin fanleaf virus gflv past field experi conduct explor cross protect manag strategi fanleaf degener result unsatisfactori mild virus strain negat impact fruit yield order select new mild gflv isol examin two old chardonnay parcel harbour vine distinct phenotyp symptom agronom perform monitor four year studi individu vine classifi three categori asymptomat gflv free vine gflv infect vine sever diseas gflv infect vine display mild symptom complet code genom sequenc gflv isol infect vine determin high throughput sequenc grapevin infect multipl genet diverg variant specif molecular featur appar gflv isol vine display mild symptom genet differenti gflv popul depend vineyard parcel observ mild symptomat grapevin identifi studi establish greenhous recov gflv variant potenti interest cross protect studi
|
D010935;D017860
|
T047;T005
|
36,298,856
|
two year genom surveil belgium sar cov pandem attain countri wide coverag monitor introduct spread emerg variant adequ sar cov genom surveil strategi proven essenti countri obtain thorough understand variant lineag import success establish within border genom surveil belgium structur implement perform individu research laboratori acquir necessari fund perform import task start nationwid genom surveil consortium establish belgium mark increas countri genom sequenc effort term intens repres perform qualiti control among particip laboratori enabl coordin collabor research project public discuss genom surveil effort belgium establish genom sequenc consortium provid overview specif consortium explor detail regard scientif studi publish result increas number belgian sar cov genom becom avail
|
D000086382;D058873
|
T047;T067
|
36,298,855
|
novel bacillus infect bacteriophag b found member propos new genus bunatrivirus work describ novel temper bacteriophag bacillus phage b bacillus infect phage widespread abund though often overlook includ temper lifestyl b isol bacteri host via mitomycin c induct host rang determin ph thermal stabil evalu whole genom b sequenc annot genom bp long contain gene tail gene b suggest phage siphovirus morphotyp found vitro silico phage use cos dna packag strategi phage genom termini locat compar analys reveal b close relat therefor assign new viral genus propos name bunatrivirus
|
D017103
|
T005
|
36,298,854
|
immun respons fourth dose sar cov mrna vaccin compar natur infect three dose vaccin solid organ transplant recipi solid organ transplant recipi sotr show higher rate covid breakthrough infect general popul nowaday vaccin key prevent strategi nonetheless sotr show lower vaccin efficaci prevent sever covid moreov emerg new sar cov variant concern highlight need improv vaccin induc immun respons administr repeat booster dose studi analyz humor cellular respons cohort sotr includ never infect sotr receiv fourth dose mrna vaccin sotr contract sar cov infect third dose analyz serum igg iga level clia elisa respect spike specif cell elispot assay report signific increas anti spike igg differ iga secret group patient booster dose natur infect still show higher iga level recov sotr compar fourth dose recipi convers show mainten posit spike specif cell respons sotr receiv fourth dose instead signific increas sotr contract infect result suggest booster either fourth dose natur infect vulner poor respond sotr improv humor cellular specif immun respons sar cov
|
D000086382;D000086663;D066027
|
T200;T047;T101;T067
|
36,298,853
|
investig associ energi metabol insect vector laodelphax striatellus rice stripe virus rsv virus intracellular parasit reli host organ complet life cycl although plant virus transmit insect vector role vector energi metabol infect process insect born plant virus unclear studi full length cdnas three energi metabol relat gene lsatpas lsmit lsnadp obtain small brown planthopp sbph laodelphax striatellus transmit rice stripe virus rsv express level lsatpas lsmit lsnadp increas respect due rsv infect repress lsatpas lsmit lsnadp rnai effect rsv nucleocapsid protein np transcript protein level repress lsatpas caus signific increas lsmit lsnadp transcript level respect repress lsmit caus signific increas lsnadp mrna level result suggest silenc lsatpas induc compensatori upregul lsmit lsnadp silenc lsmit induc compensatori upregul lsnadp studi indic co silenc lsatpas lsmit lsnadp virulifer sbphs increas atp product rsv load respect compar nonvirulifer sbphs find indic sbph energi metabol involv rsv infect provid insight associ plant virus energi metabol insect vector
|
D029364;D006430;D010942;D012275
|
T168;T005;T002;T204
|
36,298,852
|
unwant associ threat papaya crop novel potexvirus northwest argentina emerg virus isol papaya carica papaya crop northwestern nw argentina sequenc character use next generat sequenc result genom nt long encod five open read frame arrang typic potexvirus virus appear novel member within genus potexvirus blast analysi rna depend rna polymeras rdrp coat protein cp gene show highest amino acid sequenc ident respect pitaya virus x base nucleotid sequenc similar phylogenet analysi name papaya virus x propos newli character potexvirus mechan transmit papaya plant caus chlorot patch sever mosaic symptom papaya virus x papvx found nw region argentina preval could associ recent emerg adapt virus papaya nw argentina
|
D017863;D029441
|
T168;T005;T002
|
36,298,851
|
evolutionari pattern comparison sar cov delta variant countriesregion high low vaccin coverag argu vaccin breakthrough infect sar cov would like acceler emerg novel variant immun evas studi explor evolutionari pattern delta variant countriesregion relat high low vaccin coverag base larg scale sequenc result show sequenc group two cluster l r r cluster domin proport increas time higher high vaccin coverag area ii genet divers countriesregion low vaccin coverag higher one high vaccin coverag iii uniqu mutat co mutat detect differ countriesregion particular common co mutat exhibit high occur frequenc area high vaccin coverag present increas frequenc time area low vaccin coverag iv five site protein strong posit select differ countriesregion three non c u site gd tn occur frequenc high vaccin coverag area higher gd tn potenti immun pressur select site v mutat n methyladenosin site orfa ct pl detect might caus immun pressur studi suggest certain variat differ exist countriesregion high low vaccin coverag like caus host immun pressur infer extra immun pressur sar cov generat high vaccin coverag suggest promot strengthen uptak covid vaccin worldwid especi less develop area
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,850
|
host level suscept irf express influenc abil ifn inhibit kshv infect b lymphocyt kaposi sarcoma associ herpesvirus kshv associ vascular endotheli cell tumor kaposi sarcoma ks lymphoprolif disord multicentr castleman diseas mcd primari effus lymphoma pel kshv inflammatori cytokin syndrom kic dysregul proinflammatori cytokin found kshv associ diseas howev littl known role host microenviron regul kshv establish b cell present studi demonstr ifn strong inhibitori effect kshv infect subset tonsil deriv lymphocyt sampl intrins suscept infect contain higher proport nave b cell display increas level irf stat py effect ifn respons sampl associ increas frequenc germin center b cell gcb decreas infect plasma cell suggest ifn mediat modul viral dynam gc inhibit establish kshv infect
|
D001402;D006566;D019288;D007371
|
T129;T121;T025;T116;T005;T047
|
36,298,849
|
high preval undocu sar cov infect pediatr popul tyrolean district schwaz complement adult seropreval data collect time rapid sar cov mass vaccin district schwaz set establish seropreval sar cov among pediatr popul district total children mean age sd particip studi answer structur questionnair histori sar cov infect household contact symptom histori vaccin determin bind neutral antibodi level use plasma sampl provid estim overal preval sar cov infect general pediatr popul time studi use census data statistik austria daili report offici confirm case exclud studi particip report histori pcr confirm infect age standard seropreval previous unknown sar cov infect among general pediatr popul district ci ad offici document case true overal preval ci contrast offici document ci june translat proport ci case offici undocu suggest high extent silent sar cov infect pediatr popul possibl silent transmiss
|
D000086382
|
T047;T067
|
36,298,848
|
cross reactiv cell respons exist chronic lymphocyt choriomening virus infect upon pichind virus challeng immunolog memori previous encount pathogen influenc outcom sequenti infect call heterolog immun lymphocyt choriomening virus lcmv immun mice develop np specif cell respons cross reactiv pichind virus infect picv far limit data avail cross reactiv cell respons appear also chronic infect exhaust cell respons exhaust chronic viral infect treat checkpoint inhibitor might affect heterolog outcom unexpect aim studi investig cross reactiv immun respons chronic lcmv clone lcmvcl infect primari picv infect phenotyp function cell receptor tcr level moreov influenc checkpoint inhibitor therapi pd l investig cross reactiv np specif respons present function chronic environ addit chronic infect mice also protect picv mediat weight loss compar naiv picv mice alter phenotyp np specif cell detect major differ clonal divers tcr repertoir observ checkpoint inhibitor treatment pd l alter chronic lcmv infect major effect heterolog immun picv studi demonstr cross reactiv cd cell also exist set chronic infect indic clinic relev role cross reactiv cell chronic infect
|
D018052;D008216;D001117
|
T005;T047
|
36,298,847
|
healthcar associ covid across five pandem wave predict model genom analys healthcar associ sar cov infect need explor studi analysi hospit acquir infect hai ambulatori healthcar worker ahcw sar cov across pandem belgian univers hospit
|
D000086382;D003428
|
T047;T067
|
36,298,846
|
natur histori marburg virus infect support medic countermeasur develop biomed advanc research develop author part administr strateg prepared respons within us depart health human servic recogn evalu medic countermeasur anim rule requir well character reproduc anim model like predict clinic benefit marburg virus marv one two member genus marburgvirus character hemorrhag fever high case fatal rate licens vaccin therapeut avail natur histori studi consist twelv cynomolgus macaqu challeng pfu marv angola observ bodi weight temperatur viremia hematolog clinic chemistri coagul multipl time point anim succumb diseas within day exhibit sign consist observ human case includ viremia fever system inflamm coagulopathi lymphocytolysi among other addit studi determin time exposur onset diseas manifest time cours frequenc magnitud manifest studi instrument design develop medic countermeasur marburg virus diseas
|
D029024;D000078642;D008379
|
T061;T005;T047
|
36,298,845
|
parapoynx stagnali nucleopolyhedrovirus pastnpv diverg member alphabaculovirus group clade encod homolog ran gtpase report analysi genom novel alphabaculovirus parapoynx stagnali nucleopolyhedrovirus isol pastnpv cadav rice case bearer parapoynx stagnali zeller lepidoptera crambida collect rice field kerala india high throughput sequenc dna pastnpv occlus bodi assembl data yield circular genom length contig bp annot open read frame orf six homolog region hr phylogenet infer base baculovirus core gene amino acid sequenc align indic pastnpv member group clade virus genus alphabaculovirus differ phylogenet method yield differ result respect placement pastnpv four similar diverg alphabaculovirus group clade branch length kimura paramet pairwis nucleotid distanc indic pastnpv classifi current list speci genus alphabaculovirus uniqu featur pastnpv genom presenc orf encod homolog ran gtpase regul nucleocytoplasm traffick pastnpv appear acquir homolog ran relat recent lepidopteran host via horizont gene transfer
|
D017924;D009036
|
T005;T204
|
36,298,844
|
wild red deer cervus elaphus play role vector reservoir sar cov north eastern poland sever studi report high preval sar cov among white tail deer north america monitor cervid region better understand sar cov infect circul deer popul urg evalu deer exposur andor infect tobi sar cov poland sampl red deer shot hunter five hunt district north eastern poland serum nasopharyng swab collect immunofluoresc assay ifa detect anti sar cov antibodi perform well real time pcr revers transcript direct virus detect posit sampl detect evid spillov sar cov human deer popul poland
|
D003670;D000086382
|
T047;T015;T067
|
36,298,843
|
host cell redox alter promot latent hiv reactiv atyp transcript factor cooper immun cell state alter rewir hiv gene express therebi influenc viral latenc reactiv mechan still unfold use screen approach cd cell model hiv latenc reveal small molecul reactiv smore uniqu chemistri alter cd cell state consequ promot latent hiv transcript reactiv unpreced mechan action smore trigger rapid oxid stress activ redox respons program compos cell signal kinas mek erk axi atyp transcript factor ap hif cooper smore induc unusu ap phosphoryl signatur promot ap hif bind latent hiv provir genom activ consist latent hiv reactiv compromis pharmacolog inhibit oxid stress sens cell signal kinas transcript factor loss express thus function link host redox respons program viral transcript rewir notabl smore induc redox program primari cd cell reactiv latent hiv avirem patient sampl alon combin known latenc revers agent thus provid physiolog relev find suggest manipul redox sensit pathway could exploit alter cours hiv latenc thus render host cell respons help achiev steril cure
|
D015658;D015497;D018808;D014775;D017735
|
T123;T116;T045;T005;T043;T047;T038
|
36,298,842
|
evalu clinic biomark relat cd recoveri hiv infect patient year observ human immunodefici virus infect lead impair immun system function even long term antiretrovir therapi uncommon lead normal cd count cd cd ratio aim studi evalu possibl clinic biomark may relat cd cd cd ratio recoveri among hiv infect patient long term antiretrovir therapi studi includ hiv infect patient undergo sustain antiretrovir treatment minimum year clinic biomark age gender advanc hiv infect coinfect comorbid appli art regimen analyz relat rate cd cd cd increas normal rate result show higher rate cd normal associ younger age p higher cd count p start therapi acut hiv infect p higher rate cd cd ratio normal correl higher cd cell count p high hiv viral load p acut hiv infect p observ statist signific differ cd recoveri depend gender hcvhbv coinfect comorbid opportunist infect obtain result advoc current recommend introduc antiretrovir therapi soon possibl prefer acut hiv infect sinc increas chanc suffici immun reconstruct
|
D015658;D060085;D019380
|
T121;T047
|
36,298,841
|
compar hiv phylogeni character prrt pol near full length genom sequenc effort evalu accuraci hiv phylogeni base genom increas length develop comprehens near full length hiv genom rt pcr assay perform compar evalu via phylogenet analys end conduct compar analys hiv phylogeni deriv base hiv prrt hxb genom pol region hxb genom sequenc isol hiv infect patient cyprus hiv genotyp subtyp determin use six subtyp tool rega comet jphmm scueal stanford genopheno compar investig discrep generat among differ tool evalu accuraci defin hiv phylogeni sampl exhibit least one discrep subtyp result among differ subtyp tool prrt pol region pol region n select near full length hiv genom hxb genom sequenc use newli develop rt pcrsequenc assay obtain sequenc employ hiv genotyp subtyp determin subject compar phylogenet base analys observ sampl present discrep prrt region present discrep pol region rega produc fewest discrep collect region select subsequ subtyp compar phylogenet analys near full length hiv genom sequenc analys near full length hiv genom sequenc identifi discrep sampl n belong uncharacter recombin hiv strain circul recombin form crfs n belong pure group subtyp n find demonstr signific reduct discrep pol region sequenc use compar prrt region sequenc indic increas nucleotid sequenc length direct correl consist subtyp classif result also reveal discrep pol region subtyp result persist high likelihood queri sequenc recombin hiv strain belong uncharacter recombin hiv strain result studi show rega present best perform subtyp recombin hiv strain stanford perform better defin phylogeni pure group subtyp studi highlight especi popul polyphylet hiv epidem result high preval recombin hiv strain neither prrt pol region sequenc reliabl determin hiv genotyp subtyp sampl show discrep among differ subtyp tool near full length full length hiv genom sequenc suffici accur
|
D015658;D006679;D015497
|
T047;T034;T005
|
36,298,840
|
recombin human cytomegalovirus express analog sensit kinas pul novel tool function analys human cytomegalovirus hcmv member beta herpesvirus famili inflict life long latent infect host hcmv shown manipul dysregul mani cellular process one major interactor cellular host viral kinas pul ul gene essenti viral replic kinas defici mutant pul display sever replic defect recent anoth group establish analog sensit version pul protein mutant kinas treat non hydrolys atp analog therebi inhibit kinas function process revers remov atp analog media chang introduc mutant version pul protein laboratori strain ad hcmv badwt creat bad ul viral mutant mutant virus replic normal infect cell absenc atp analog maintain abil phosphoryl cellular substrat howev treat atp analog bad ul display defect product intra extracellular viral dna product viral progeni furthermor presenc mb pp well establish substrat pul longer hyperphosphoryl effect detect earli h post treatment allow studi pul without complic low viral titer nevertheless observ target effect mb pp sever cellular process consid approach
|
D003587;D004279
|
T005;T114
|
36,298,839
|
compar studi vaccin unvaccin hospitalis patient retrospect popul studi hospitalis patient sar cov infect spanish popul inhabit studi aim compar characterist fulli partial vaccin unvaccin coronavirus diseas covid patient hospitalis popul habit
|
D000086382
|
T047;T067
|
36,298,838
|
phage shape microbi dynam metabol model communiti mimick cider ferment beverag model microbi communiti often studi better understand interact flux ferment process howev model take account potenti impact bacteriophag phage recogn driver microbi communiti scarc especi ferment food studi aim investig behavior cider model microbi communiti subject disturb presenc absenc phage two differ temperatur c c model microbi communiti compos three lactic acid bacteria lab strain belong speci liquorilactobacillus mali leuconostoc mesenteroid oenococcus oeni saccharomyc uvarum yeast strain two phage select target l mali ln mesenteroid strain order follow behavior microbi communiti model phage microbi strain enumer sever time point metabol signatur sugar consumpt product organ acid volatil organ compound model microbi communiti monitor c communiti phage p signific closer control condit c condit without phage microbi level similar condit c p character high concentr compound phenylethanol ethyl octano isoamyl alcohol global complex metabol signatur condit condit l mali ln mesenteroid domin uvarum oeni less present condit character high concentr ethyl lactat c condit p differ condit c ln mesenteroid detect strain reach approxim level metabol rang condit p less import condit c current studi show influenc phage model microbi communiti dynam metabol disturb phenomenon temperatur depend
|
D001435;D055549;D010626
|
T121;T005;T109
|
36,298,837
|
seropreval four polyomavirus link dermatolog diseas new find comprehens analysi aim studi seropreval human polyomavirus hpyv link skin diseas total serum sampl analys enzym link immunosorb assay detect igg antibodi merkel cell polyomavirus mcpyv hpyv hpyv trichodysplasia spinulosa associ polyomavirus tspyv use recombin major capsid protein virus individu age year median sort seven age group lt gt year adulthood seropreval mcpyv hpyv hpyv tspyv respect four polyomavirus increas seroposit age reach adulthood level signific increas seroreact age group rate alreadi infect individu also show signific differ adulthood seropositv relat stabl age except tspyv elev seroposit observ elder gt year age group sinc seroepidemiolog data publish wide rang virus studi perform comprehens analysi compar publish age specif seroposit data although cohort method even antigen variabl among studi similar result studi polyomavirus mcpyv geograph distinct genotyp might exist might also result differ seropreval data addit studi compar studi group method requir clarifi whether geograph differ
|
D011120;D027601;D059965;D014412
|
T005;T191;T047
|
36,298,836
|
serolog evid sever fever thrombocytopenia syndrom virus igm posit identifi healthi resid vietnam sever fever thrombocytopenia syndrom sfts emerg tick born viral diseas preval east asia also report southeast asia sinc sfts patient vietnam first report howev seropreval sever fever thrombocytopenia syndrom virus sftsv vietnam report investig seropreval sftsv vietnam collect serum sampl healthi resid thua thien hue quang nam provinc vietnam seropreval sftsv assess use immunofluoresc antibodi assay ifa enzym link immunosorb assay elisa focus reduct neutral test frnt assay seropreval anti sftsv igm igg observ high igm posit gt titer neutral antibodi sftsv rang pakistan sftsv infect confirm use microneutr test mnt assay preval elisa show high seropreval sftsv henc seropreval rate vietnam similar pakistan number sfts patient could increas vietnam
|
D000085142;D002044;D016856;D017282
|
T047;T005
|
36,298,835
|
novel h dhodh inhibitor med prevent influenza virus replic block pyrimidin biosynthesi pharmacolog manag influenza virus iv infect still pose seri challeng due limit anti iv drug arsenal therefor develop new anti influenza agent effect antigen differ iv therefor urgent prioriti meet need host target antivir htas evalu altern complementari approach current direct act agent daa therapi iv infect contribut antivir strategi studi character anti iv activ med novel small molecul inhibitor human dihydroorot dehydrogenas h dhodh key cellular enzym de novo pyrimidin biosynthesi pathway med exhibit potent antivir activ iav ibv replic revers addit exogen uridin cytidin h dhodh product orot thus indic med target notabl h dhodh activ iv infect cell med use combin either dipyridamol dpi inhibitor pyrimidin salvag pathway anti iv daa n hydroxycytidin nhc synergist anti iv activ observ whole result indic med potenti hta candid develop novel anti iv intervent approach either singl agent combin regimen daa
|
D007251;D009976
|
T047
|
36,298,834
|
cellular psmb protein suppress influenza virus replic target ns protein nonstructur protein ns influenza virus iav possess multipl function inhibit host antivir immun respons facilit viral infect search cellular protein interact iav ns protein yeast two hybrid system adopt proteasom famili member psmb proteasom subunit beta type found interact ns protein screen experi bind domain two protein also determin use system physic interact ns cellular psmb protein confirm co immunoprecipit assay confoc microscopi mammalian cell neither transient stabli express ns protein affect psmb express cell contrast psmb reduc ns protein express level especi presenc mg expect function ns protein inhibit interferon activ enhanc transient gene express suppress psmb psmb knockdown enhanc iav replic overexpress attenu iav replic thus result studi suggest cellular psmb protein interact possibl facilit degrad ns protein turn suppress iav replic
|
D009980;D007251
|
T005;T047
|
36,298,833
|
common nonpersist acquisit plant virus plant associ fungi investig virus host rang cross infect import better understand epidemiolog emerg virus previous research group discov natur infect plant rna virus cumber mosaic virus genus cucumovirus famili bromovirida plant pathogen basidiomycet fungus rhizoctonia solani isol potato plant grown field extend studi investig whether similar cross infect plant virus occur wide plant associ fungi natur condit various veget plant spinach leaf mustard radish celeri veget show typic virus like diseas collect field shandong provinc china high throughput sequenc reveal least known rna virus belong differ genera includ potyvirus fabavirus polerovirus waikavirus cucumovirus along novel virus candid belong virus genera infect associ collect veget plant leaf sampl contain multipl plant virus larg number filament fungal strain isol veget leaf sampl subject screen presenc plant virus rt pcr sanger sequenc pcr product reveal among fungal strain test around carri plant virus mani strain harbor multipl plant virus plant virus detect fungal isol divers virus speci limit particular virus genera howev prolong mainten fungal cultur laboratori mani fungal strain lost virus sequenc fungal dna indic fungal strain harbor plant virus relat plant pathogen andor endophyt fungi belong genera alternaria lecanicillium sarocladium observ suggest nonpersist acquisit plant virus fungi may common occur natur find highlight possibl role fungi life cycl spread evolut plant virus
|
D010942;D017800;D017799
|
T005
|
36,298,832
|
sar cov pre exposur prophylaxi sotrovimab tixagevimabcilgavimab immunocompromis patient singl center experi immunocompromis patient experi reduc vaccin effect higher risk coronavirus diseas covid death pre exposur prophylaxi prep aim protect patient far tixagevimabcilgavimab author use prep paper aim provid real world data use tixagevimabcilgavimab sotrovimab sever acut respiratori syndrom coronavirus sar cov prep immunocompromis patient compar evolut antibodi level report incid breakthrough infect retrospect singl center analysi conduct includ immunocompromis patient inadequ vaccin respons receiv covid prep clinic januari june initi patient receiv sotrovimab patient receiv tixagevimabcilgavimab antibodi level first prep sotrovimab remain high sever month infus median bauml month respect higher titer tixagevimabcilgavimab inject even month later vs bauml p overal breakthrough infect rare compar overal infect rate period austrian popul mild diseas cours rapid viral clearanc median day sotrovimab may addit option sar cov prep
|
D065129;D000086382
|
T061;T047;T067
|
36,298,831
|
innat immun inflamm intervent hbv infect hepat b virus hbv infect still one danger viral ill hbv infect around million individu worldwid hepat b mani individu ultim develop hepatocellular carcinoma hcc sixth common cancer third lead caus cancer relat death worldwid innat immun act first line defens hbv infect activ antivir gene along immun respons pro inflammatori cytokin trigger enhanc antivir respons may result acut chronic liver inflamm especi clearanc virus unsuccess degre host innat immun inflammatori respons domin hbv infect liver pathogenesi thus crucial figur signal pathway involv activ antivir factor inflammatori cytokin review interplay hbv signal pathway mediat innat immun respons inflamm addit summar current therapeut strategi hbv infect via modul innat immun inflamm character mechan underli hbv host interplay might provid new approach cure chronic hbv infect
|
D006528;D008113;D006509;D019694
|
T047;T191
|
36,298,830
|
small rna analys ceratobasidium isol infect three endornavirus isol three endornavirus speci identifi co infect unidentifi speci ceratobasidium identifi symbiont within root wild plant terrestri orchid pterostyli vittata western australia isogen line fungal isol lack three mycovirus deriv virus infect isol observ presenc endornavirus influenc gene express fungal host sequenc fungus deriv small rna speci virus infect virus free isogen line compar presenc mycovirus influenc express small rnas fungus deriv small rna speci identifi express regul regul presenc virus fourteen novel micro rna like rnas cer milrna predict gene target predict differenti express cer milrna quit ambigu howev fungal gene involv transcript regul catalysi molecular bind metabol activ gene express dna metabol process regul activ differenti express presenc mycovirus
|
D000067148;D012328;D029595
|
T005;T002
|
36,298,829
|
viral hijack bet protein protein bromodomain extermin domain bet famili mediat critic host function cell prolifer transcript regul innat immun respons make prefer target virus multidomain protein best known transcript effector abl read acetyl histon non histon protein tandem bromodomain also contain short motif bind domain extratermin domain recogn transcript regulatori protein describ differ virus evolv hijack disrupt host bet protein function direct interact bet famili member support propag network virus bet interact emerg high intric may complic use small molecul bet inhibitor current clinic develop treatment cancer cardiovascular diseas treat viral infect
|
D014157;D006657
|
T123;T116
|
36,298,828
|
measl rubella incid molecular epidemiolog seneg tempor region trend twelv year nation surveil investig epidemiolog measl rubella infect seneg base data twelv consecut year laboratori base surveil conduct phylogenet analys circul measl virus sera measl suspect case collect test measl rubella specif igm antibodi use enzym link immunosorb assay elisa throat swab collect patient clinic diagnos measl confirm revers transcript polymeras chain reaction rt pcr viral genotyp among laboratori test specimen measl suspect case serolog evid measl rubella infect confirm respect incid rubella low ci case per million peopl wherea progress toward measl pre elimin target lt case per million peopl per year appear stall ci case per million peopl phylogenet analys reveal senegales measl strain belong genotyp b rubella virus sequenc obtain studi consist genotyp c nation surveil data suggest despit low incid measl rubella remain endem seneg concern stagnat declin measl infect repres signific challeng goal region elimin
|
D012409;D008457
|
T047
|
36,298,827
|
network interact porcin epidem diarrhea virus nucleocapsid host cellular protein host virus protein interact critic intracellular viral propag understand interact cellular viral protein may help us develop new antivir strategi porcin epidem diarrhea virus pedv high contagi coronavirus caus sever damag global swine industri employ co immunoprecipit liquid chromatographi mass spectrometri character uniqu pedv nucleocapsid n protein bind protein infect vero cell protein protein interact network ppi creat gene ontolog go annot kyoto encyclopedia gene genom kegg databas analys reveal pedv n bound protein belong differ cellular pathway nucleic acid bind ribonucleoprotein complex bind rna methyltransferas polymeras activ interact pedv n protein putat protein tripartit motif contain dead box rna helicas gbp stress granul assembl factor heat shock protein famili member heat shock protein alpha famili class b member yth domain contain nucleolin box bind protein vimentin heterogen nuclear ribonucleoprotein ab karyopherin subunit alpha confirm vitro co immunoprecipit assay summari studi interact network facilit identif antivir therapeut strategi novel target pedv infect
|
D053485;D013553;D018352;D009696
|
T123;T005;T114;T047
|
36,298,826
|
sar cov variant specif infect immun profil detect human lung mous model small anim model accur model pathogenesi sar cov variant requir ongo research effort modifi human immun system mous model support replic sar cov implant human lung tissu mice creat tko blt lung l mice compar infect two differ variant human lung model infect tko blt l mice sar cov recapitul higher infect b variant anim becom infect higher sustain viral load compar mice challeng earli b lineag virus viral lesion observ lung organoid differ detect viral variant expect partial overlap distinct immun profil also observ variant greater th profil vido greater th profil b infect overal tko blt l mous support sar cov infect recapitul key known similar differ infect pathogenesi well reveal previous unreport differ immun respons two viral variant thus tko blt l model may serv use anim model studi immunopathobiolog newli emerg variant context genuin human lung tissu immun cell
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,825
|
develop singl cell transcriptom applic covid last three year sever acut respiratori syndrom coronavirus sar cov relat health crisi claim six million live caus usd trillion loss global economi sar cov continu mutat evolv high basic reproduct number r result varieti clinic manifest rang asymptomat infect acut respiratori distress syndrom ard even death gain better understand coronavirus diseas covid critic investig compon caus various clinic manifest singl cell sequenc substanti advantag term identifi differenti express gene among individu cell provid better understand various physiolog patholog process articl review use singl cell transcriptom covid research examin immun respons dispar generat sar cov offer insight regard improv covid diagnosi treatment plan
|
D000086382
|
T047;T067
|
36,298,824
|
system bioinformat reveal possibl relationship covid develop neurolog diseas neuropsychiatr disord coronavirus diseas covid associ increas incid neurolog diseas neuropsychiatr disord infect contribut develop remain investig investig possibl relationship covid develop ten neurolog disord three neuropsychiatr disord explor two patholog mechan dysregul host biolog process via virus host protein protein interact ppis ii autoreact sever acut respiratori syndrom coronavirus sar cov epitop host self protein via molecular mimicri also identifi potenti genet risk factor combin sar cov infect might lead diseas develop analysi indic neurodegen diseas nds higher number diseas associ biolog process modul sar cov via virus host ppis neuropsychiatr disord sequenc similar analysi indic presenc sever match mer andor mer linear motif sar cov epitop autoreact epitop found alzheim diseas ad parkinson diseas pd myasthenia gravi mg multipl sclerosi ms result includ autoreact epitop recogn amyloid beta precursor protein app microtubul associ protein tau mapt acetylcholin receptor glial fibrillari acid protein gfap neurofila light polypeptid nfl major myelin protein altogeth result suggest might increas risk develop nds covid via autoreact virus host ppis
|
D000086382;D019636
|
T047;T067
|
36,298,823
|
compar pharmacokinet dual inhibitor hiv nbd rat dog proof concept evalu antivir potenc scid hu mous model earlier report substanti progress design gp antagonist notabl discov nbd activ gp antagonist also show antivir activ hiv revers transcriptas rt also confirm bind hiv rt x ray crystallographi dual inhibit high signific intrigu compound bridg dntp nnrti bind site inhibit polymeras activ isol rt enzymat assay novel find expect lead new avenu design novel class hiv dual inhibitor therefor need advanc inhibitor preclin assess end report pharmacokinet pk studi nbd rat dog subsequ assess toxic therapeut efficaci vivo scid hu thyliv mous model pk data indic favor half life excel oral bioavail f nbd show measur toxic mice treatment reduc hiv replic mgkg per day absenc clear evid protect hiv mediat human thymocyt deplet data indic potenti inhibitor anti hiv agent need assess non human primat nhp model
|
D015658;D015497;D019380;D006679
|
T121;T047;T034;T005
|
36,298,822
|
host plant shape codon usag pattern turnip mosaic virus turnip mosaic virus tumv import pathogen caus mosaic diseas veget crop worldwid belong genus potyvirus famili potyvirida previous area genet variat popul structur timescal migrat tumv well studi howev codon usag pattern host adapt analysi tumv unclear composit bias codon usag tumv perform use non recombin sequenc found relat stabl chang exist genom composit slight lower codon usag choic display tumv protein code sequenc statist analysi present codon usag pattern tumv protein code sequenc main affect natur select mutat pressur natur select key influenc factor codon adapt index cai relat codon deoptim index rcdi reveal tumv gene strong adapt brassica oleracea present data similar index sid analysi also indic b oleracea potenti prefer host tumv studi provid first insight assess codon usag bias tumv base complet genom provid better advic futur research tumv origin evolut pattern
|
D000081183;D017800
|
T045;T005
|
36,298,821
|
improv protocol comprehens etiolog character skin wart determin causat human papillomavirus type histolog confirm common wart human papillomavirus hpvs etiolog associ various benign malign neoplasm cutan mucos epithelia describ improv diagnost protocol comprehens character causat hpv type common wart broad spectrum pcrs follow sanger sequenc two previous describ seven newli develop type specif quantit real time pcrs qpcrs coupl human beta globin qpcr use diagnosi hpv infect wart ii estim cellular viral load hpv type detect iii determin etiolog role histolog confirm fresh frozen common wart tissu sampl total differ causat hpv type determin hpv posit wart hpv preval follow hpv hpv hpv hpv cellular viral load hpv hpv estim first time common wart signific higher viral load hpv hpv hpv addit show first time hpv etiolog associ develop common wart signific older patient hpv hpv wherea hpv induc wart signific smaller wart caus hpv hpv hpv hpv
|
D030361;D014860;D052685
|
T047;T005
|
36,298,820
|
novel self cleav viroid like rna identifi rna prepar citrus tree direct associ plant viroid viroid like satellit rnas infecti circular non protein code rnas report plant far viroid famili avsunviroida viroid like satellit rnas share self cleav activ mediat hammerhead ribozym hhrzs endow rna polar strand use homolog independ method base search conserv structur motif hhrzs read contig high throughput sequenc rnaseq librari identifi novel small nt viroid like rna librari citrus reticulata tree viroid like rna contain hhrz polar strand northern blot hybrid assay show circular form polar strand rna tentat name citrus transient associ hammerhead viroid like rna ctahvd lr exist support replic symmetr pathway roll circl mechan ctahvd lr adopt rod like conform typic featur quasispeci hhrzs shown activ transcript absenc protein ctahvd lr graft transmiss first identif found origin citrus sourc repeat search follow year suggest actual direct associ plant therefor possibl novel self cleav viroid like rna actual associ anoth organ eg fungus turn transient associ citrus plant propos
|
D014772;D016337;D002957
|
T168;T005;T126;T114;T002
|
36,298,819
|
tdp toxic yeast associ reduct autophagi delet tip pbp counteract effect human tdp overexpress yeast toxic form cytoplasm aggreg mechan toxic unknown genet screen tdp toxic modifi yeast system previous identifi protein includ pbp enhanc tdp toxic determin yeast delet pbp reduc tdp toxic overexpress enhanc toxic led discoveri human homolog atxn associ al risk thus yeast system relev human diseas show delet new yeast gene tip likewis suppress tdp toxic also found tdp overexpress toxic associ reduc autophagi consist find system increas autophagi reduc tdp toxic contrast report enhanc autophagi tdp overexpress yeast interest found delet pbp tip reduc tdp toxic elimin tdp inhibit autophagi suggest toxic tdp express yeast part due inhibit autophagi delet pbp tip may reduc tdp toxic prevent tdp inhibit autophagi
|
D001343;D012441;D029701
|
T004;T116;T043
|
36,298,818
|
efficaci differ test scenario reduc transfus transmit hepat b virus tt hbv infect risk efficaci differ screen scenario reduc hepat b virus hbv transmiss risk compar risk without screen model donat four geograph region subject hepat b surfac antigen hbsag individu donat nucleic acid amplif test id nat use weusten model estim infect risk red blood cell rbc transfus eight hbv infect stage evalu multipl screen strategi base minipool mp id nat option differ sensit efficaci reduc risk efficaci reduc hbv transmiss risk screen scenario across region vari hbsag id nat anti hbc high sensit id nat alon achiev slight higher risk reduct minipool donat mp nat combin hbsag anti hbc id nat screen laps repeat donor addit risk remov hbsag test minim lt model outcom two previous report use multi region databas suggest one could consid id nat alon test scenario altern mp nat serolog base test algorithm restrict serolog test first time donor
|
D006509;D022783
|
T047;T005
|
36,298,817
|
preval risk factor htlv infect inriversid rural popul state par human lymphotrop virus htlv htlv infect describ sever amazonian popul howev still lack data preval virus riparian popul live rural area state par present studi aim evalu preval htlv infect four riverin communiti one rural area state par describ possibl risk factor infect total individu respond epidemiolog survey gave blood sampl collect anti htlv antibodi immunoenzymat assay eia serum reactiv sampl subject confirm line assay inno lia provir dna screen use real time pcr qpcr total preval htlv ci htlv htlv preval sex women men among seroposit patient report sexual activ report habit use condom sexual relat intrafamili infect also observ result reinforc need public polici prevent block spread htlv especi riparian communiti subject difficulti access unifi health system sistema nico de sadesus infect individu need clinic monitor surveil earli diagnosi symptom associ htlv
|
D015490;D015491;D015368
|
T047;T005
|
36,298,816
|
small molecul raf antivir therapi act pedv infect porcin epidem diarrhea virus pedv member famili coronavirida caus acut diarrhea vomit dehydr high mortal newborn piglet caus signific econom loss pig industri current specif drug avail treat pedv virus depend exclus cellular machineri ensur effici replic cycl present studi found small molecul raf anticanc drug shown potent inhibitor raf reduc viral load pedv order magnitud vero cell protect piglet virus challeng raf reduc pedv product mediat cytoskeleton arrang target host cell translat machineri treatment raf inhibit viral entri pedv glycoprotein pseudotyp viral vector particl pedv pp half maxim effect concentr ec nm raf also present potent inhibitori activ viral infect sar cov pp sar cov pp present work may provid start point progress toward develop antivir strategi effect coronavirus pedv
|
D053485;D013553;D000086382
|
T005;T067;T047
|
36,298,815
|
structur insight chaperon assist assembl simplifi tail fiber myocyanophag pam first step phage infect receptor bind protein rbps tail fiber respons recogn specif host surfac receptor proper fold assembl tail fiber usual requir chaperon encod phage genom despit extens studi phage structur molecular mechan phage tail fiber assembl remain larg unknown use minim myocyanophag term pam isol lake chaohu demonstr chaperon gp form stabl complex tail fiber gp stoichiometri cryo electron microscopi structur complex reveal elong structur gp trimer embrac distal moieti gp trimer center gp subunit consist three domain n termin helic domain requir dock basepl tumor necrosi factor tnf like glycin rich domain respons recogn host receptor gp subunit consist two domain non conserv n termin sandwich domain bind tnf like glycin rich domain fiber c termin helic domain mediat trimerizationassembl fiber structur analysi enabl us propos assembl mechan phage tail fiber chaperon first protect intertwin repetit distal moieti fiber subunit ensur proper fold high plastic structur element eventu enabl format trimer fiber find provid structur basi design engin phage fiber biotechnolog applic
|
D001435
|
T005
|
36,298,814
|
pre pandem cross reactiv immun sar cov among central west african popul two year emerg covid coronavirus diseas signific region differ morbid persist differ clear show lower incid rate sever region african asian contin work report aim test hypothesi pre pandem natur immun acquir human popul central western africa would therefor pose hypothesi origin antigen sin virus antigen close sever acut respiratori syndrom coronavirus sar cov identifi pre exist immun sera sampl collect emerg covid test detect presenc igg react antibodi sar cov protein major signific sera sampl french blood donor collect pandem serv control result show statist signific differ antibodi preval collect sampl africa control sampl collect franc given novelti result next step consist highlight neutral antibodi evalu potenti pre pandem protect acquir immun sar cov conclus result suggest investig african sub region test popul could potenti partial pre expos covid pandem antigen yet non identifi coronavirus
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,813
|
review vector born rice virus rice oryza sativa l one major stapl food global consumpt major roadblock global rice product persist loss crop caus plant diseas includ rice blast sheath blight bacteri blight particular various vector born rice viral diseas sinc late th centuri speci rice virus record rice produc area worldwid caus vari degre damag rice product among southern rice black streak dwarf virus srbsdv rice black streak dwarf virus rbsdv asia rice yellow mottl virus rymv africa rice stripe necrosi virus rsnv america current pose serious threat rice yield review systemat emerg damag rice viral diseas symptomatolog transmiss biolog rice virus arm race virus rice plant well insect vector strategi prevent control rice viral diseas
|
D012275;D010942;D012087;D006430
|
T168;T005;T204;T002
|
36,298,812
|
covid infant less month sever sever diseas compar adult sever fatal covid diseas much less common children howev higher risk progress report infant differ pediatr covid sever score report literatur
|
D000086382
|
T047;T067
|
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