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36,298,811
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antivir activ ficus rubiginosa leaf extract hsv hcov e pv ficus rubiginosa plant extract show antimicrobi activ evid concern antivir properti report antivir activ methanol extract meoh n hexan h ethyl acet ea fraction herp simplex virus hsv human coronavirus hcov e poliovirus pv investig differ phase viral infect vero ccl cell line confirm antivir efficaci qpcr conduct record cytotox concentr gml meoh h ea respect assess dimethylthiazol yl diphenyl h tetrazolium bromid mtt assay h treatment ficus rubiginosa leaf extract inhibit replic hsv earli stage infect show complet inhibit gml hcov e total inhibit gml meoh h well gml ea observ otherwis activ record pv leaf extract could act direct viral envelop destructur lipid membran andor direct block enrich protein viral surfac verifi gene inhibit suggest treatment h ea impair hsv hcov e replic greater antivir effici hsv compar hcov e possibl due greater affin ficus rubiginosa toward membran glycoprotein andor differ lipid envelop
|
D018259;D028941;D030681;D017955
|
T168;T005;T002
|
36,298,810
|
rhabdomyolysi covid infect case report review literatur rhabdomyolysi condit muscl break potenti lead renal dysfunct often occur secondari precipit factor viral bacteri infect common precipit initi rhabdomyolysi recent healthcar system across world challeng pandem sever acut respiratori syndrom coronavirus sar cov caus coronavirus diseas covid diseas sar cov infect recogn caus respiratori cardiovascular compromis thromboembol event acut kidney injuri aki howev known whether precipit rhabdomyolysi limit number case sar cov infect preced rhabdomyolysi report date report case year old woman develop rhabdomyolysi short sar cov infect covid initi present muscular pain creatin kinas level iul mild rise creatinin level moll success recov intraven fluid support also review literatur summaris previous report case rhabdomyolysi precipit sar cov highlight need consid diagnosi patient present sar cov myalgia
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D000086382;D012206
|
T047;T046;T067
|
36,298,809
|
pseudorabi virus associ wild anim review potenti reservoir cross host transmiss pseudorabi virus prv receiv widespread attent potenti health effect human wildlif domest anim livestock review focus prv dynam wildlif given import wild origin prv transmiss domest farm anim wild boar pig raccoon serv reservoir prv viral transmiss domest livestock occur via sever rout wild herd exposur contamin meat consumpt insect vector transmiss mani endang felin canin speci infect prv acut diseas death within h first confirm human case prv infect mainland china report thus prv exhibit potenti danger cross host transmiss like associ inappropri vaccin poor awar insuffici biosecur current vaccin provid full protect prv anim summar epidemiolog pathogenesi prv infect wild domest farm anim may facilit design novel therapeut strategi control prv infect improv wildlif protect china
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D011558;D011557;D013553
|
T005;T047
|
36,298,808
|
year epidem infecti bursal diseas virus china infecti bursal diseas ibd acut high contagi immunosuppress diseas chicken caus virus ibdv critic threaten develop global chicken industri caus huge econom loss larg countri poultri industri epidem histori ibdv china year briefli discuss summar first time report first classic strain ibdv appear china late late earli virul ibdv vvibdv rapid swept across entireti china threaten healthi develop poultri industri year variant ibdv long term latent circul accumul mutat sinc earli sudden reappear novel variant strain nvaribdv china mid current coexist various ibdv genotyp newli emerg nvaribdv adb persist circul vvibdv ab two predomin epidem strain endang poultri industri continu epidemiolog test develop new prevent control agent import requir attent report great signific scientif cognit comprehens prevent control ibdv epidem
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D007243;D011201;D018175
|
T005;T047
|
36,298,807
|
broad spectrum antivir antivir combin editori updat special issu receiv great deal attent sever import paper recent ad
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D000998
|
T121
|
36,298,806
|
antibodi respons rotavirus c pre farrow natur plan exposur gilt piglet longitudin studi conduct investig dynam genotyp specif g p antibodi respons differ dose rotavirus c rvc natur plan exposur npe gilt serum colostrummilk piglet serum compar antibodi respons rotavirus npe rva genotyp g g p p g p antigen rvc express mammalian bacteri cell use develop individu indirect elisa antigen group dose npe result signific higher igg iga level colostrum compar group piglet serum group p igg level signific higher studi group day piglet serum higher iga level group piglet compar group antigen comparison colostrum antibodi level rotavirus rva rvc reveal colostrum rvc igg iga titer lower rva titer irrespect g p type next generat sequenc ngs detect rvc genotyp g p circul piglet popul window lactogen immun conclud low rvc load npe materi real time pcr ct valu fail induc suffici matern immun gilt low colostrum rvc antibodi level passiv prevent piglet natur rvc infect farrow room best knowledg first studi compar differ antibodi respons porcin rva rvc commerci set
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D012401;D012400;D013553
|
T005;T047
|
36,298,805
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phylogeographi biolog character h influenza virus influenza virus iav widespread wild bird reservoir sixteen hemagglutinin subtyp associ wild waterfowl host subtyp isol infrequ one h iav studi detect three h iav ana crecca ana formosa poyang lake china one isol phylogenet analysi reveal genom sequenc three h virus belong eurasian lineag except pa gene one np gene belong north american lineag growth kinet show h isol grew better mdck cell moreov although h isol effici replic balbc mice bind sialic acid sa sa link receptor addit examin phylodynam h virus bayesian phylogeograph analysi result show two major transmiss rout h iav asia oceania europ south america ana arenaria genera major host viral transmiss find help us better understand evolut h iav highlight need continu surveil iav circul wild bird
|
D009980;D005585
|
T005;T047
|
36,298,804
|
prospect altern host emerg polerovirus cotton landscap southeastern unit state identif altern host act virus inoculum sourc vector reservoir landscap critic understand virus epidem cotton leafrol dwarf virus clrdv serious pathogen cotton product transmit cottonmelon aphid aphi gossypii persist circul non propag manner clrdv first report unit state alabama thereaft sever cotton produc state clrdv sinc establish southeastern unit state role altern host clrdv establish clear fourteen common plant speci landscap includ crop weed ornament cotton hollyhock marshmallow countri mallow abutilon arrowleaf sida okra hibiscus squash chickpea even primros henbit palmer amaranth prick sida test potenti altern host clrdv along experiment host nicotiana benthamiana via aphid mediat transmiss assay clrdv detect follow inocul hibiscus okra n benthamiana palmer amaranth prick sida rt pcr other clrdv accumul determin rt qpcr highest n benthamiana compar cotton host howev aphid feed clrdv infect prick sida hibiscus okra alon abl acquir clrdv back transmit non infect cotton seedl addit altern clrdv host support aphid develop par cotton howev instanc aphid fit reduc compar cotton overal studi demonstr plant host agricultur landscap serv clrdv inoculum sourc aphid reservoir could possibl play role reoccur epidem clrdv southeastern unit state
|
D052679;D001042
|
T005;T204
|
36,298,803
|
first report detect denv human blood plasma near infrar spectroscopi dengu virus denv world common arbovir infect estim million peopl risk infect million symptomat case death per year current diagnosi denv includ use molecular method polymeras chain reaction cost routin use near infrar spectroscopi nir techniqu high throughput techniqu involv shine beam infrar light biolog sampl collect reflect spectrum use machin learn algorithm develop predict algorithm use nir detect denv artifici introduc whole blood plasma serum collect human donor machin learn algorithm develop use artifici neural network ann result model use predict independ sampl denv plasma sampl detect overal accuraci sensit specif n n n respect howev predict sensit n n specif n n achiev detect denv whole blood serum sampl respect denv peak observ nm nm repres c h stretch peak nm relat methyl group peak nm relat satur fatti group find indic potenti nir diagnost tool denv howev work recommend assess sensit detect denv peopl natur infect virus determin capac differenti denv serotyp arbovirus
|
D003715;D003716
|
T047;T005
|
36,298,802
|
patholog studi hantaan virus infect mice simul sever hemorrhag fever renal syndrom hantaan virus causat agent hemorrhag fever renal syndrom hfrs hantaan virus strain korean hemorrhag fever virus clone khf caus weight loss renal hemorrhag laboratori mice clone khf singl ek amino acid chang glycoprotein avirul variant studi khf khf compar evalu patholog differ mice vitro vivo characterist two glycoprotein signific differ vitro howev virul khf strain target lung caus pneumonia edema vivo strain induc high infect level liver caus hepat howev petechi hemorrhag glycogen storag reduct observ khf infect mice alon renal hemorrhag observ use viral antigen tubular region khf infect mice addit increas white blood cell level neutrophilia found khf infect mice microarray analysi liver cell show cd cell activ acut phase protein product neutrophil activ induc khf infect khf infect signific increas vivo histolog clinicopatholog find similar patient hfrs
|
D018063;D006480
|
T005;T047
|
36,298,801
|
extend host rang fusarium poae virus fusarium poae fusarium speci field fusarium poae virus fpv betapartitivirus one mycovirus discov earlier due veget incompat barrier often exist differ speci strain filament fungi fpv thought limit host f poae non hypovirul mycovirus past year field novel strain fpv fpv fa two dsrna segment nt consist identifi f asiaticum isol field fpv fa induc abnorm morpholog hypovirul f asiaticum along high viral load fpv fa detect f asiaticum f tricinctum strain fpv fa sampl site strain site identifi fpv fa horizont transmiss experi show fpv fa transfer f asiaticum f poae f tricinctum f graminearum select analysi fpv fa reveal rdrp cp strong purifi select c termin side rdrp posit select region amino acid mutat rdrp mutat cp appear caus variat host rang virul fpv fa
|
D005670;D000067148;D012328
|
T005;T004
|
36,298,800
|
amino acid substitut within seven octapeptid repeat insert prion protein gene associ short term cours major seven octapeptid repeat insert opri carrier exhibit relat earli onset slowli progress cours present three case opri includ two rapid progress compar clinic ancillari characterist short term long term diseas cours well factor influenc diseas cours clinic ancillari featur three new opri patient chines pedigre analyz global data opri case collect review literatur case group accord clinic durat per scjd criteria two year cut chines pedigre glycin glutam substitut within opri insert enhanc hydrophil prion protein two case pedigre short diseas cours consist typic clinic ancillari featur scjd addit member pedigre later onset p lt shorter diseas cours p lt compar previous report opri case cis similar age onset diseas cours case cis v opri case shorter clinic cours n later onset p higher rate hyperintens mri p higher frequenc cis v p compar longer clinic cours n clinic present opri signific heterogen codon cis v amino acid substitut within repeat insert possibl contributor short term diseas cours opri
|
D011328;D017096;D007562
|
T005;T116;T047
|
36,298,799
|
newcastl diseas genotyp vii preval poultri wild bird egypt newcastl diseas virus ndv genotyp vii high pathogen orthoavulavirus caus multipl outbreak among poultri egypt sinc studi aim observ preval genet divers ndv prevail domest wild bird egyptian governor total oropharyng swab wild bird swab domest bird flock includ chicken duck turkey pelican collect differ geograph region within governor virus isol propag via embryon egg reveal swab sampl produc allanto fluid contain haemagglutin activ suggest virus presenc use rt pcr target f gene success detect ndv sampl geograph preval ndv isol governor domest bird migratori non migratori wild bird follow whole genom sequenc assembl six ndv genom sequenc genom coverag includ five full f gene sequenc ndv strain carri high virul phylogenet analysi reveal strain belong class ii within genotyp vii genet similar yet geograph distinct virul ndv isol poultri wild bird may allud extern role contribut dissemin ndv poultri popul across egypt one contribut may migratori behaviour wild bird howev investig must implement support find studi addit continu genom surveil wild bird poultri would necessari monitor ndv dissemin genet diversif across egypt aim control diseas protect poultri product
|
D009521;D011201
|
T047
|
36,298,798
|
increas cd cd doubl posit cell hantaan virus infect hantaan virus htnv infect caus epidem hemorrhag fever renal syndrom hfrs main asia well known cell mediat anti viral immun respons although previous studi show doubl posit dp cell littl portion lymphocyt involv adapt immun respons virus infect kinet chang role htnv infect yet explor studi character dp cell hfrs patient base flow cytometri data combin scrna seq data show htnv infect caus upregul dp cell peripher blood correl diseas stage scrna seq data cluster dp cell unravel gene express profil estim order cell product granzym b cda dp cell abund tcr distribut indic anti viral properti dp cell conclus studi identifi first time accumul dp cell peripher blood hfrs patient suggest dp cell belong cd cell lineag dp cell share similar characterist cytotox cell ctl exert anti viral role hfrs
|
D018063;D006480;D018778
|
T005;T047
|
36,298,797
|
design ankyrin repeat protein new class viral entri inhibitor design ankyrin repeat protein darpin engin protein compris consensus design ankyrin repeat scaffold tight pack repeat form continu hydrophob core larg groov like solvent access surfac creat bind surfac darpin domain recogn target interest high specif affin generat use synthet combinatori librari vitro select method link togeth singl molecul build multispecif multifunct protein without affect express function modular architectur darpin offer unpreced possibl design open avenu innov antivir strategi
|
D000090922;D023581
|
T123;T121;T116
|
36,298,796
|
ampliseq illumina technolog enabl detail molecular epidemiolog rabi lyssavirus infect formalin fix paraffin embed tissu whole genom sequenc rabi lyssavirus rabv enabl generat high detail phylogeni reveal viral transmiss pattern diseas reservoir speci inform high import inform best practic respect wildlif rabi control howev specimen avail formalin fix paraffin embed ffpe sampl recalcitr analys due damag inflict tissu process relat short amplicon generat standard rt pcr method make generat full length genom sequenc tedious high parallel shotgun sequenc total rna potenti overcom challeng low percentag read repres virus may limit ampliseq technolog enabl massiv multiplex amplif nucleic acid produc larg number short pcr product strategi appli sequenc entir viral genom use rabi virus analysi report previous studi describ generat ampliseq illumina primer panel design base global sequenc divers rabi virus enabl effici viral genom amplif sequenc rabi posit ffpe sampl subsequ use data detail phylogenet analysi virus demonstr
|
D011820;D011818;D009696
|
T123;T005;T114;T047
|
36,298,795
|
estim r spread first asf epidem itali fresh carcass fifti year spread european contin african swine fever asf virus detect first time north itali piedmont wild boar carcass decemb first six month epidem central role wild boar diseas transmiss confirm outbreak occur two differ area declar infect virus enter domest pig farm second tempor cluster identifi center countri lazio understand asf dynam wild boar prerequisit prevent spread design appli effect surveil control plan aim work describ evalu data collect first six month asf epidem itali estim basic reproduct number r order quantifi extent diseas spread r estim signific differ two spatio tempor cluster asf itali identifi two infect area base time necessari number case doubl td exponenti decay model result r piedmont lazio provid quantit knowledg epidemiolog asf itali paramet could repres fundament tool model countri specif asf transmiss monitor spread sampl effort need detect diseas earli
|
D000357;D000358;D058872
|
T047;T005;T067
|
36,298,794
|
gene express analysi adapt insect cell influenza vlp product use rna sequenc adapt laboratori evolut use improv product influenza hemagglutinin ha display virus like particl vlps insect cell howev littl known under biolog mechan promot higher ha vlp express adapt cell line articl present studi gene express pattern associ high produc insect high five cell adapt neutral ph comparison non adapt cell express influenza ha vlps rna seq show decreas amount read map host cell genom along infect increas map baculovirus transgen total host cell gene found differenti express adapt non adapt cell throughout infect either regul time point evalu h post infect interest host cell gene found regul approxim ratio differenti express baculovirus gene found regul infect adapt cell pathway analysi differenti express gene reveal enrich ribosom biosynthesi carbohydr amino acid lipid metabol addit oxid phosphoryl protein fold sort degrad pathway also found overrepres find contribut knowledg biolog mechan insect cell baculovirus mediat transient express assist identif potenti engin target increas recombin protein product futur
|
D007251;D007252
|
T129;T047;T121;T109
|
36,298,793
|
comparison harmon differ semi autom autom qrt pcr assay assess sar cov sar cov diagnost cycl threshold ct valu qrt pcrs semi quantit estim patient viral load howev relev analyt differ qrt pcr assay often neglect studi design identifi differ five common use assay ii demonstr straightforward strategi harmon qrt pcrs sar cov carri oropharyng swab sampl use three fulli autom alin coba genexpert two semi autom genesig rida gene assay qualit result positiveneg show excel compar fulli autom assay alin semi autom method ct valu signific vari method median valu rang alin rida gene genesig indic lowest sensit semi autom method pass bablok analysi reveal system bias assay specif viral load concentr calcul base generat individu standard curv result much better compar assay appli calcul signific differ longer detect studi highlight relev analyt differ sar cov qrt pcr assay lead diverg decis mandatori isol infect individu second propos strategi harmon qrt pcr assay achiev better compar find particular interest laboratori util differ assay
|
D012608;D000086382
|
T047;T067
|
36,298,792
|
construct vero cell line express human icam develop rhinovirus vaccin human rhinovirus hrvs small non envelop rna virus belong enterovirus genus within picornavirida famili known caus common cold though symptom general mild healthi individu econom burden associ hrv infect signific vaccin could prevent diseas vero cell base viral vaccin platform technolog consid vaccin develop unfortun hrv strain unabl propag vero cell due lack major receptor hrv group b intercellular adhes molecul icam also known cd therefor stabl human icam express vero cell clone generat transfect icam gene vero cell select clone overexpress icam cell surfac cell bank made express icam stabl least passag veroicam cell parent vero cell infect four hrv prototyp b b replic four virus detect veroicam parent vero cell altogeth vero cell express icam could effici propag test hrv strain therefor icam express cell could use tool develop futur product polyval hrv vaccin virus use icam receptor
|
D018799;D010850;D012229;D014709;D014765
|
T129;T121;T116;T025;T005;T047
|
36,298,791
|
suscept resurg covid outbreak follow vaccin rollout model studi use recent propos suscept asymptomat infect vaccin remov saivr model studi impact key factor affect covid vaccin rollout effect suscept resurg epidem saivr model expand wide use suscept infecti remov sir model describ epidem ad compart includ asymptomat infect vaccin v popul solv model numer make predict suscept resurg covid epidem depend initi vaccin coverag import load continu vaccin contagi sar cov variant persist immun immun wane condit paramet model repres report epidemiolog characterist sar cov virus diseas spread countri high level vaccin coverag find help explain combin effect differ vaccin coverag level wane immun lead distinct pattern resurg covid epidem either surg endem observ countri implement differ covid health polici achiev differ vaccin popul plateaus vaccin rollout first half
|
D000086382;D007252
|
T129;T121;T067;T109;T047
|
36,298,790
|
revers genet artifici replic system borna diseas virus borna diseas virus bodv neurotrop rna virus belong famili bornavirida within order mononegaviral wherea bodv caus neurolog behavior disord call borna diseas bd wide rang mammal virul human debat sever decad howev seri case report recent year establish natur bodv zoonot pathogen caus fatal enceph human although mani virolog properti bodv reveal date mechan caus fatal enceph human remain unclear addit effect vaccin antivir drug use clinic practic revers genet approach generat replic compet recombin virus full length cdna clone power tool use understand viral properti also develop vaccin antivir drug rescu recombin bodv rbodv first report howev due slow natur replic virus rescu high titer rbodv requir sever month limit use system review summar histori revers genet artifici replic system orthobornavirus explor recent progress effort rescu rbodv
|
D001891;D004660
|
T005;T047
|
36,298,789
|
divers genet characterist astrovirus anim yunnan provinc astrovirus astv singl strand rna virus includ two main genera mamastrovirus mastv avastrovirus aastv astv detect differ mammal bird characterist multipl cross speci transmiss gene recombin acceler process virus mutat pose potenti threat human be anim husbandri yunnan provinc global hotspot rich biodivers abund anim resourc import area signific public health secur neighbor southeast asian countri studi collect sampl speci anim yunnan provinc astv detect result show posit rate astv extrem high genet divers observ differ anim speci potenti cross speci transmiss event also detect rodent bird therefor astv wide distribut high divers gene risk cross speci transmiss peopl deserv attent region
|
D019350;D052676;D001257
|
T047;T005
|
36,298,788
|
perform pressur insight diagnost test burden uk nation health servic clinic virolog laboratori sar cov pandem uk nation health servic nhs clinic virolog depart provid repertoir test clinic sampl detect presenc viral genom materi host immun respons viral infect decemb novel coronavirus sar cov emerg quick develop global pandem nhs laboratori respond rapid upscal test capabl date littl inform impact increas sar cov screen non sar cov test within nhs laboratori report detail virolog test request receiv leicest base nhs virolog laboratori januari may data show spite dramat increas screen along multipl logist staf issu leicest virolog depart most abl maintain level servic non respiratori virus test meet new increas sar cov test
|
D058873;D000086382
|
T047;T067
|
36,298,787
|
relat role ambient temperatur mobil pattern shape transmiss heterogen sar cov japan assess effect ambient temperatur mobil pattern transmiss covid epidemiolog year pandem japan prefectur specif daili time seri confirm coronavirus diseas covid case meteorolog variabl level retail recreat mobil eg activ go restaur cafe shop center number vaccin collect six prefectur japan may march combin standard time seri general addit model gam distribut lag non linear model dlnm determin exposur lag respons associ time vari effect reproduct number rt ambient temperatur retail recreat mobil control wide rang potenti confound util statist model first distribut mean ambient temperatur ie c associ confid interv ci increas rt compar optimum ambient temperatur ie c retail recreat mobil th percentil associ ci increas rt optim level ie find provid better understand ambient temperatur mobil pattern shape sever acut respiratori syndrom coronavirus sar cov transmiss find provid valuabl epidemiolog insight public health polici control diseas transmiss
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,786
|
neotrop sylvat mosquito aed aegypti compet transmit dd attenu yellow fever virus vaccin virem new world non human primat besid human thousand non human primat nhps die recent outbreak caus yellow fever virus yfv brazil vaccin nhps yfv yf dd attenu virus emerg public health strategi would reduc sylvat transmiss also preserv endang suscept speci hypothesi establish uncontrol transmiss attenu virus natur rais assess vector compet four sylvat mosquito speci haemagogus leucocelaenus haemagogus janthinomyscapricornii sabeth albiprivus sabeth identicus well urban vector aed aegypti yf dd attenu vaccin virus fed direct eleven virem lion tamarin artifici challeng virus infect detect mosquito engorg virem lion tamarin whose viremia rang ffuml artifici take pfuml low viremia present yf dd vaccin new world nhps combin low capac null dissemin abil sylvat domest mosquito attenu virus suggest risk transmiss natur thus vaccin captiv free live nhps yfv safe public health strategi
|
D000330;D015004;D051039
|
T047;T015;T204
|
36,298,785
|
relationship dugb virus infect autophagi epitheli cell dugb orthonairovirus dugv tick born arbovirus within order bunyaviral although display mild pathogen potenti dugv genet relat crimean congo hemorrhag fever virus cchfv anoth orthonairovirus caus sever liver dysfunct hemorrhag fever high mortal rate human previous observ cchfv infect could massiv recruit lipid maplc lc core factor involv autophag degrad cytosol compon ask whether dugv infect also substanti impact autophagi machineri epitheli cell observ dugv infect impos lc lipid cultur hepatocyt dugv infect also caus upregul maplc sqstmp transcript level howev moder seen cchfv infect contrast unlik cchfv infect modul core autophagi factor could influenc lc lipid viral particl product silenc atg andor atg diminish induct lc lipid slight upregul level infecti dugv particl product overal result compat notion epitheli cell infect dugv vitro autophagi machineri may recruit exert certain level restrict viral replic thus relationship dugv infect autophagi epitheli cell appear present similar distinct seen cchfv infect
|
D003225;D006479;D029281
|
T005;T047
|
36,298,784
|
assess adher clinic guidelin patient chronic hepat b adher guidelin associ improv long term outcom patient chronic hepat b chb aim studi degre adher determin non adher manag guidelin low endem countri
|
D019694;D006528;D008113;D015658;D006526
|
T047;T191
|
36,298,783
|
antivir activ asaron rhizom acorus gramineus murin norovirus norovirus nvs major caus foodborn diseas worldwid rhizom acorus gramineus agr use tradit medicin plant food addit studi agr bioactiv compon asaron asaron show signific antivir activ murin nv mnv pre treatment two log reduct viral plaqu also demonstr strong inhibit bind type saliva recombin p domain deriv human nv hunv gii asaron also inhibit bind p domain receptor mm concentr depend manner induc mark reduct suggest may reduc structur stabil block receptor bind p domain simul digest condit agr extract asaron asaron show signific reduct mnv plaqu log asaron show potenti develop scaffold anti nv agent
|
D029023;D029322
|
T121;T005;T002
|
36,298,782
|
evalu five buffer inactiv monkeypox virus feasibl virus detect use panther fusion open access system rapid diagnosi key contain viral outbreak howev current monkeypox outbreak major deterr rapid test requir higher biocontain potenti infecti monkeypox virus specimen current cdc guidelin requir dna extract process pcr amplif perform biosafeti level unless vaccin personnel perform assay increas turn around time make certain laboratori insuffici equip handl specimen patient suspect monkeypox infect investig abil five commerci avail lysi buffer heat inactiv monkeypox virus also optim use monkeypox virus holog panther specimen lysi buffer detect virus panther fusion open access system use publish generic clade specif monkeypox virus primer probe
|
D008993;D045908
|
T005;T047
|
36,298,781
|
detect hpv rna extracellular vesicl neuroendocrin cervic cancer cell background neuroendocrin carcinoma cervix necc aggress rare type cervic cancer five year overal surviv low standard therapi base control trial type tumour local advanc metastas time diagnosi extracellular vesicl ev could carrier viral dnarna given vital role cellular communic content ev deriv necc cell investig due lack cell line known whether contain human papillomavirus hpv dnarna method presenc viral e dnarna ev purifi cultur recent establish necc cell line gumc evalu use droplet digit polymeras chain reaction ddpcr ev character use nanoparticl track analysi nta size distribut transmiss electron microscopi tem morpholog western blot cd bioanalys rna quantiti qualiti result hpv viral rna dna detect ev gumc use ddpcr nta identifi ev mean diamet nm tem confirm normal morpholog shape size western blot analysi confirm presenc ev associ protein cd ev found enrich small rnas use bioanalys conclus hpv rna found ev neuroendocrin cervic cancer could involv pathogenesi diseas use diagnost biomark
|
D002583;D030361;D000067128;D018278
|
T026;T047;T191
|
36,298,780
|
construct transcriptom studi chicken ifnar knockout cell line reveal essenti role cell growth apoptosi relat pathway duck tembusu virus infect industri vaccin product overwhelm exist antivir innat immun respons domin type interferon ifn cell would key factor improv effect product cost vaccin studi report construct ifn receptor ifnar knockout df cell line ko ifnar support much effici replic duck tembusu virus dtmuv newcastl diseas virus ndv gammacoronavirus infecti bronchiti virus ibv transcriptom analysi dtmuv infect ko ifnar cell demonstr dtmuv main activ gene signal pathway relat cell growth apoptosi among jun myc nfkbia signific regul furthermor knockdown zinc finger helicas helz interferon induc protein ifi two gene regul wild type ko ifnar cell signific increas replic dtmuv rna studi pave way studi mechan under dtmuv mediat ifn independ regul virus replic meanwhil provid potenti cell resourc effici product cell base avian virus vaccin
|
D018177;D005416;D007370;D011201
|
T129;T121;T116;T005;T047
|
36,298,779
|
molnupiravir use alon seem safe effect outpati covid therapi hemodialyz patient kidney transplant recipi molnupiravir demonstr vitro antivir activ posit sens rna virus includ sar cov studi aim present result outpati molnupiravir use kidney transplant recipi hemodialysi patient first month poland
|
D000086382;D016030
|
T061;T047;T067
|
36,298,778
|
phylogeographi rotavirus gp detect argentina evid transpacif dissemin rotavirus one lead caus diarrhea children gp unusu associ genotyp detect moder frequenc symptomat children argen tina unlik previous sporad identif aim studi analyz dissemin pattern gp lineag iv strain detect argentina nucleotid sequenc vp gene argentin gp strain studi discret phylodynam analys togeth worldwid relev g lineag iv strain bay factor bf use assess strength epidemiolog associ countri phylodynam analys determin evolutionari rate hdp substitutionssiteyear likewis recent common ancestor year old date back hdp spatiotempor dynam analysi reveal south korea countri origin argentin strain posterior probabl ancestr state also evidenc signific rate diffus south korea argentina bf detect g south america relat case detect reveal new g introduct region support transpacif dissemin
|
D012401;D012400
|
T005;T047
|
36,298,777
|
crystal structur epstein barr virus bcl homolog bhrf bound bid puma bh motif peptid apoptosi power defens mechan use multicellular organ counteract viral infect respons prematur host cell suicid virus evolv numer countermeasur ensur cell viabil optim replic encod protein homolog structur function cellular pro surviv bcl protein epstein barr virus ebv member gammaherpesvirida encod bcl homolog bhrf potent inhibitor bcl mediat apoptosi bhrf act direct target bid puma two proapoptot protein bcl famili determin crystal structur bhrf bound peptid span bcl bind motif bcl homolog motif bh bid puma bhrf engag bh peptid use canon ligand bind groov bcl fold maintain salt bridg arg residu conserv asp residu bh motif mimick canon ionic interact seen host bcl bh motif complex furthermor bid puma util fifth bind pocket canon ligand bind groov bhrf provid addit hydrophob interact distinct interact previous seen bak bim find provid structur basi ebv mediat suppress host cell apoptosi reveal flexibl virus encod bcl protein mimick key interact endogen host signal pathway
|
D046011;D020031
|
T047;T015
|
36,298,776
|
isol identif genet phylogenet analysi two differ genotyp bovin parainfluenza virus china bovin parainfluenza virus bpiv one sever virus contribut bovin respiratori diseas complex brdc studi isol bpiv attempt pcr posit swab madin darbi bovin kidney mdbk cell nine sampl show obvious cytopath lesion identifi bpiv revers transcript polymeras chain reaction amplif sequenc genom isol xj xj sequenc use illumina sequenc technolog determin length bp bp respect phylogenet analysi reveal isol xj genotyp b isol xj genotyp c addit two isol multipl amino acid chang nucleocapsid protein fusion protein hemagglutininneuraminidas major antigen protein allow recognit presenc bpiv type b chines cattl herd hope help trace origin bpiv improv understand differ genotyp provid data support vaccin develop
|
D029101;D018184
|
T005;T047
|
36,298,775
|
identif novel solinvivirus nuclear local associ mass mortal cultur whiteleg shrimp penaeus vannamei emerg spread diseas caus virus shrimp aquacultur uncommon sinc unusu mortal affect brazilian shrimp industri associ unusu mortal novel variant infecti myonecrosi virus imnv transcriptom analysi diseas shrimp show addit diverg viral sequenc assign famili solinvivirida novel virus tentat term penaeus vannamei solinvivirus pvsv genbank access op full length genom pvsv kb exclud poli tail code polyprotein aa five conserv domain code helicas rdrp calicivirus coat protein g patch tegument protein identifi genom organ pvsv similar nylan deria fulva virus solinvivirus uniqu featur virus differ member solinvivirida presenc putat nuclear local signal tissu tropism virus wide infect cell hepatopancrea gastrointestin tract lymphoid organ muscl tissu anoth uniqu featur rna virus penaeid shrimp show nuclear local situ hybrid pvsv wide distribut brazil found state maranho state periz de baixo piaui state mexeriqueira cear state camocim jaguaruana aracati alto santo par state detect coinfect imnv diagnost method develop real time rt pcr situ hybrid effect detect pathogen employ limit spread furthermor identif pvsv show increas host rang relat new famili solinvivirida
|
D033561;D012328
|
T005;T204
|
36,298,774
|
macrophag migrat inhibitori factor mif promot increas proport high permiss th like cell profil hiv infect studi evalu role mifcd axi function cd lymphocyt cdtl hiv infect mdms healthi donor infect r tropic transmittedfound tf hiv strain day post mdm infect allogen co cultur uninfect cdtls plus mif stimulus perform cytokin product evalu elisa mif plasma level peopl hiv pwh evalu elisa phenotyp infect rate cdtls pwh analyz mif stimulus intracellular cytokin transcript factor evalu flow cytometri data analyz parametr non parametr method mif stimul hiv infect mdms induc increas express il il il cdtlmdm co cultur mif treatment increas il arort express cdtls higher concentr il supernat also observ result recapitul use transmittedfound tf hiv strain mif treatment appear affect memori cdtls nave cdtls mif block show negat impact ila cdtl proport higher mif concentr pwh deriv plasma correl higher il cdtl percentag final mif stimul pwh deriv pbmcs led increas th like popul mif may contribut viral pathogenesi generat microenviron enrich activ mediat th like cdtls known high suscept hiv infect relev viral persist observ establish basi consid mif possibl therapeut target
|
D015658;D008263;D058504
|
T129;T123;T116;T025;T047
|
36,298,773
|
capsid structur aleutian mink diseas virus human parvovirus new face parvovirus famili portrait parvovirus small singl strand dna virus non envelop capsid determin capsid structur provid framework annot region import viral life cycl aleutian mink diseas virus amdv pathogen mink human parvovirus parv infect human parvovirus belong genera amdoparvovirus tetraparvovirus respect aleutian mink diseas caus amdv major threat mink farm clear clinic manifest establish follow infect parv human capsid structur amdv parv determin via cryo electron microscopi resolut respect despit low amino acid sequenc ident virus share icosahedr natur parvovirus capsid viral protein vps assembl capsid via two three five fold symmetri vp relat interact display major structur variabl surfac loop capsid structur superpos onto parvovirus capsid structur amdv parv add current knowledg structur platform parvovirus permit futur function annot virus help understand infect mechan molecular level develop diagnost therapeut
|
D000454;D017992;D010322
|
T005;T047
|
36,298,772
|
review bioactiv compound porcin enter coronavirus pig diarrhea univers problem process pig breed serious affect develop pig industri porcin enter coronavirus pecov common pathogen caus diarrhea pig current includ transmiss gastroenter virus tgev porcin epidem diarrhea virus pedv porcin deltacoronavirus pdcov swine acut diarrhea syndrom coronavirus sad cov prosper world transport trade spread virus becom wider faster make even necessari prevent pecov paper host factor requir effici replic cov compound exhibit inhibitori effect summar promot develop drug pecov studi also help discov general host factor affect replic cov provid refer prevent treatment cov
|
D017934;D018352;D013553;D053485
|
T005;T047
|
36,298,771
|
phylodynam high pathogen avian influenza hn virus circul indonesian poultri first detect high pathogen avian influenza hnx virus spread extens worldwid hpaiv hn first detect indonesia endem poultri countri ever sinc howev indonesia limit inform relat phylodynam hpaiv hn poultri present studi aim increas understand evolut tempor dynam hpaiv hn indonesian poultri end hpaiv hn hemagglutinin sequenc virus collect analyz use bayesian evolutionari analysi sampl tree result indic common ancestor indonesian poultri hpaiv hn aros approxim five year common ancestor worldwid hpai hnx addit studi indic two introduct hpaiv hn occur virus continu evolv due extens spread among poultri furthermor studi reveal diverg hn clade c hn clade b clade c b share common ancestor clade suggest clade origin diverg china asian countri sinc limit sequenc surveil data hpaiv hn wild bird indonesia exact role wild bird spread hpaiv indonesia current unknown evolutionari dynam indonesian hpaiv hn highlight import continu improv genom surveil adequ control measur differ region poultri wild bird spatial genom surveil use take adequ control measur therefor help prevent futur evolut hpai hn pandem threat
|
D053124;D005585;D011201
|
T005;T047
|
36,298,770
|
viral small terminas diverg structur framework conserv biolog function genom packag motor bacteriophag herpesvirus built two terminas subunit known larg terl small ter essenti viral genom packag terl structur composit assembl empti capsid well mechan atp depend dna packag studi depth shed light chemo mechan coupl atp hydrolysi dna transloc instead signific less known small terminas subunit ter dispens even inhibitori vitro essenti vivo take advantag recent revolut cryo electron microscopi cryo em build upon wealth crystallograph structur phage terss review take inventori known terss studi date analysi suggest ter evolv diversifi flexibl molecular framework conserv biolog function minim sequenc quaternari structur conserv fit differ packag strategi environment condit
|
D019065;D001435
|
T005;T038
|
36,298,769
|
transfus acquir hiv histori evolut screen test current challeng unreport antiretrovir drug use brazil prevent hiv acquisit blood transfus emerg present day review current challeng delin experi fundao pr sanguehemocentro de paulo brazil highlight quest improv blood safeti evolut increas sensit specif screen test concern establish stringent criteria screen potenti blood donor emphas current criteria identifi defer candid high risk acquir sexual transmit diseas summar futur challeng relat identif donor unreport use antiretrovir drug prophylaxi possibl hiv exposur treatment hiv infect whose viral express undetect current analys need better understand motiv hiv expos donor educ risk transfus mediat hiv transmiss despit low undetect viral load situat tradit hiv rna antibodi detect assay remain negat sensit analys need identifi potenti donor risk hiv transmiss
|
D015658;D019966
|
T033;T047;T048
|
36,298,768
|
japanes enceph antigen complex virus structur immun last three decad sever flavivirus concern belong differ antigen group expand geograph result presenc often one virus singl antigen group area europ africa australia addit multipl virus belong japanes enceph je serogroup co circul morpholog heterogen flavivirus dictat antibodi recognit affect virus neutral influenc infect control latter impact sequenti infect involv divers flavivirus co circul within region cross reactiv ensu complex molecular virus host interplay lead either cross protect diseas enhanc howev molecular determin mechan drive outcom unclear review provid overview epidemiolog four je serocomplex virus paramet affect flavivir heterogen antibodi recognit host immun respons current knowledg cross reactiv involv je serocomplex flavivirus lead differenti clinic outcom may inform futur prevent therapeut intervent
|
D018349;D004672;D005416;D004664;D014902
|
T005;T047
|
36,298,767
|
assess impact toll like receptor agonist synthet lipopeptid macrophag suscept respons african swine fever virus infect toll like receptor tlr ligand attract attent prophylact immunopotenti agent pathogen includ virus previous report synthet diacyl lipopeptid mag pamcysp polar porcin macrophag toward proinflammatori antimicrobi phenotyp investig role modul monocyt deriv macrophag mom respons african swine fever virus asfv etiolog agent one greatest threat global pig industri two asfv isol compar attenu nhp virul og effect virus infect modul surfac marker express mhc mhc ii dr cd cd cd observ mag pamcysp treat mom infect use multipl infect moi mag pamcysp treat mom releas higher level il il il ra il respons infect nhp asfv compar og infect mock infect control surpris infect use moi virul asfv og isol replic even slight effici mag pamcysp treat mom effect also extend treatment mom two lipopeptid mag pamcysp mag pamcysmag data suggest limit applic tlr agonist prophylact immunopotenti agent virul asfv highlight abil virul og impair macrophag defens
|
D000358;D000357
|
T005;T047
|
36,298,766
|
transcriptom analysi duck chicken brain infect aquat bird bornavirus abbv aquat bird bornavirus abbv neurotrop virus infect waterfowl result persist infect experiment infect show muscovi duck chicken support persist abbv infect central nervous system cns week post infect wpi without develop clinic diseas aim present studi describ transcriptom profil brain experiment infect muscovi duck chicken infect abbv wpi transcrib rna sequenc next generat sequenc analyz princip compon analysi pca differenti gene express function annot differenti express gene evalu gene ontolog go kyoto encyclopedia gene genom kegg analysi pca show infect duck sampl wpi cluster separ control sampl chicken wpi wpi form separ cluster duck gene differenti express wpi wpi major high differenti express gene deg upregul hand infect chicken fewer deg wpi wpi major high number deg downregul wpi upregul wpi function annot show enrich go term immun associ speci howev term associ innat immun respons predomin enrich duck wherea chicken enrich innat adapt immun respons immun associ pathway also enrich accord kegg pathway analysi speci overal transcriptom analysi duck chicken brain show main biolog respons abbv infect immun associ correspond level inflamm cns
|
D028981;D012328
|
T005
|
36,298,765
|
enhanc express proto oncogen c myc downregul traf ubiquitin alv infect hen infect avian leukosi virus subgroup alv experi stunt growth immunosuppress potenti lymphoma develop accord past research promot inhibit tumor growth studi df cell infect alv rhb gp express measur various time point recombin plasmid encod chicken gene short hairpin rna target chicken shrna construct transfect df cell determin effect alv replic potenti signal pathway explor use bioinformat predict co immunoprecipit techniqu result demonstr alv promot alv infect df cell upregul inhibit traf ubiquitin promot stat phosphoryl phosphoryl stat p stat promot express proto oncogen c myc may lead tumorigenesi studi help understand tumorigen process alv provid refer prevent control alv
|
D001354;D001353;D011201
|
T005;T191;T047
|
36,298,764
|
sand fli pathogen lowland emilia romagna northern itali case sand fli born diseas emilia romagna region mening caus toscana virus human leishmaniasi report annual dedic surveil system sand fli abund hilli part region lowland unsuit habitat sand fli found lower number environ respect hilli area studi retriev sand fli collect entomolog surveil west nile virus assess abund screen presenc pathogen four year period collect sand fli half abund sand fli speci phlebotomus ph perfiliewi follow ph perniciosus rare sampl speci ph papatasi ph mascittii sergentomyia minuta sand fli collect end may end septemb pattern distribut speci character abund number ph perfiliewi eastern part region fall almost none western part region ph perniciosus seem uniform distribut throughout test femal sand fli pool detect phlebovirus leishmania speci use differ pcr protocol toscana virus leishmania infantum human pathogen detect pool pool respect also detect fermo virus phlebovirus uncharacter term relev public health pool record differ sand fli abund differ season emilia romagna season favor sand fli also detect pathogen transmit insect find impli health risk link sand fli born pathogen survey area lowland despit consid less suitabl habitat sand fli respect hilli area
|
D011576;D010691;D018314;D029301;D016856
|
T005;T204
|
36,298,763
|
toward next generat sequenc hiv drug resist test clinic set hiv genotyp resist test grt standard care clinic manag hivaid patient recent decad popul sanger sequenc foundat drug resist monitor clinic set howev advent high throughput next generat sequenc caus paradigm shift toward detect character low abund covert mutat would otherwis miss popul sequenc clinic signific mutat potenti compromis efficaci antiretrovir therapi caus poor virolog suppress therefor import develop sensit method reliabl detect clinic action drug resist mutat drms evalu diagnost perform laboratori develop high throughput sequenc base grt use archiv clinic sampl previous test drug resist use popul sequenc expect high throughput sequenc found drms detect popul sequenc signific addit drms identifi high throughput sequenc statist signific base mcnemar test overal result complement previous studi support notion two method well correl high throughput sequenc method appear excel altern drug resist test clinic set
|
D015497;D015658;D006679;D019380
|
T121;T005;T034;T047
|
36,298,762
|
imbalanc angiogenesi pregnanc complic sar cov infect covid preeclampsia pree share ang ii mediat endotheli dysfunct result signific dysregul ras imbalanc proport anti angiogen pro angiogen solubl plasmat factor note increas incid pree report among covid infect mother compar general pregnant popul two promis angiogen marker solubl fms like tyrosin kinas receptor sflt major antiangiogen factor placent growth factor plgf power angiogen factor sinc marker proven use predict diagnosi sever pree studi aim evalu matern serum level pregnanc complic sar cov infect assess potenti use guid manag women retrospect analysi sar cov posit pregnant women perform serum level sflt plgf collect diagnosi sar cov infect hospit begin steroidhydroxychloroquin andor antithrombot therapi sflt plgf ratio stratifi use cut valu clinic util diagnosi predict pree low lt intermedi high gt th week gestat total women includ sign symptom covid hospit present asymptomat none vaccin mean gestat age diagnosi sar cov infect week symptomat patient week day asymptomat one p sflt serum level higher sar cov posit asymptomat patient compar women covid relat symptom pgml vs pgml p sflt plgf admiss lt symptomat women compar asymptomat patient p note two three women admit intens care unit low ratio lt turn rate patient sflt plgf admiss gt signific differ two group asymptomat patient vs none symptomat patient p present placent dysfunct like pree n fgr n note stillbirth matern neonat death among symptomat patient also case pree fgr small gestat age neonat diagnos conclus data suggest sar cov infect pregnanc could influenc angiogen balanc signific patholog alter sflt plgf ratio identifi symptomat phase howev left untreat sar cov infect could potenti trigger placent dysfunct
|
D000086382;D011225
|
T047;T046;T067
|
36,298,761
|
vaccinia virus dna helicas structur combin singl particl cryo electron microscopi alphafold predict poxvirus larg dna virus linear doubl strand dna genom circular extrem helicas primas compos six ident kda subunit requir dna replic consist primas fragment flexibl attach hexamer c termin polypeptid res confirm nucleotid hydrolas dna bind activ elus helicas activ determin structur singl particl cryo electron microscopi display aaa helicas core flank n c termin domain model build great help predict structur use alphafold structur n termin domain form well defin tight ring resolut decreas toward c terminus still allow fit predict structur n termin domain partial present papillomavirus e polyomavirus lta helicas well bacteriophag nrs helicas domain also close relat aaa helicas domain use pfam domain databas dn domain follow duf poxd domain could assign cryo em structur provid first structur dn poxd domain domain organ identifi famili putat helicas larg dna virus bacteriophag selfish dna element
|
D019915;D014616
|
T005;T126;T116
|
36,298,760
|
catch wave detect strain specif sar cov peptid clinic sampl collect infect wave divers geograph locat coronavirus diseas covid pandem caus sever acut respiratori syndrom coronavirus sar cov result major health crisi worldwid continu emerg new strain result new viral variant drive wave infect pcr antigen detect assay routin use detect clinic infect howev emerg newer strain present challeng detect one altern detect character variant specif peptid sequenc viral protein use mass spectrometri ms base method ms method potenti help diagnost vaccin develop understand dynam chang viral proteom associ specif strain infect wave studi develop access flexibl shareabl bioinformat workflow implement galaxi platform detect variant specif peptid sequenc ms data deriv clinic sampl demonstr util workflow character publish clinic data across world various pandem wave analysi identifi six sar cov variant specif peptid suitabl confid detect ms common collect clinic sampl
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,759
|
current vitro vivo model studi mcpyv associ mcc merkel cell polyomavirus mcpyv human polyomavirus current known caus human cancer mcpyv believ etiolog factor least case rare aggress skin malign merkel cell carcinoma mcc mcpyv mcc tumor clonal integr viral genom result continu express two viral protein viral small antigen st truncat form viral larg antigen oncogen potenti mcpyv function properti viral antigen contribut neoplasia becom increas well character recent develop model system recapitul biolog mcpyv mcc review summar understand mcpyv role mcc follow current state vitro vivo model system use studi mcpyv contribut carcinogenesi also highlight remain challeng within field major consider relat ongo develop vitro vivo model mcpyv mcc
|
D059965;D014412;D027601;D015266;D012878
|
T005;T191;T047
|
36,298,758
|
lumpi skin diseas outbreak africa europ asia multipl chang point analysi time seri forecast lsd import transboundari diseas affect cattl industri worldwid object studi determin trend signific chang point forecast number lsd outbreak report africa europ asia lsd outbreak report data januari januari world organ anim health analyz determin statist signific chang point data use binari segment forecast number lsd report use auto regress move averag arima neural network auto regress nnar model four signific chang point identifi contin year third fourth chang point african data period highest mean number lsd report chang point lsd outbreak europ correspond massiv outbreak asia highest number lsd report third detect chang point next three year arima nnar forecast rise number lsd report africa steadi number europ howev arima predict stabl number outbreak asia wherea nnar predict increas studi provid inform contribut better understand epidemiolog lsd
|
D008166;D008167
|
T047;T005
|
36,298,757
|
syntenin inhibitor block endosom entri sar cov panel rna virus virus depend host factor order effici establish infect replic target interact host factor provid attract strategi develop novel antivir syntenin protein known regul architectur cellular membran involv protein traffick previous shown import human papilloma virus hpv infect show high potent metabol stabl peptid inhibitor bind pdz domain syntenin inhibit sever acut respiratori syndrom coronavirus sar cov infect block endosom entri virus furthermor found inhibitor also hamper chikungunya infect strong reduc flavivirus infect complet depend receptor mediat endocytosi entri conclus identifi novel broad spectrum antivir inhibitor effici target broad rang rna virus
|
D000086382;D012328
|
T047;T005;T067
|
36,298,756
|
avian reovirus b interact caveolin lipid raft dynamin depend caveola mediat endocytosi caveolin cav basic compon caveola special form lipid raft play essenti role endocyt viral entri howev evid direct involv caveola cav avian reovirus arv entri remain insuffici studi membran lipid raft isol deterg resist microdomain drms sucros gradient centrifug capsid protein b arv found associ cav drms fraction addit interact arv b protein cav demonstr immunofluoresc co local co immunoprecipit assay furthermor found intern arv sensit caveola dynamin inhibitor insensit clathrin inhibitor conclus result indic arv b protein interact cav dynamin depend caveola mediat endocytosi entri arv
|
D051242;D030101
|
T123;T005;T116;T192
|
36,298,755
|
revisit viral rna depend rna polymeras insight recent structur studi rna depend rna polymeras rdrps repres distinct yet versatil class nucleic acid polymeras encod rna virus replic transcript genom structur rdrp compar cup right hand consist finger palm thumb subdomain despit presenc common structur core rdrps differ signific mechanist detail rna bind polymer present review aim explor incongru light recent structur studi rdrp complex divers cofactor rna moieti analog inhibitor
|
D012328;D009696
|
T123;T005;T114
|
36,298,754
|
sar cov transmiss belgian french speak primari school epidemiolog pilot studi school point attent pandem closur one mitig measur taken better understand dynam transmiss sar cov elementari educ essenti advis decisionmak conduct uncontrol non intervent prospect studi belgian french speak school describ role attend asymptomat children school staff spread covid estim transmiss other particip select school test sar cov use polymeras chain reaction pcr analysi saliva sampl week basi six consecut visit accord recommend forc time symptomat individu exclud school per studi protocol particip blind pcr result asymptomat particip maintain school among select school pupil school staff includ januari may overal saliva sampl collect came back posit posit sampl came isol case observ asymptomat posit children remain school lead increas number case cluster howev conduct studi period low preval belgium would interest conduct analysi high preval period
|
D000086402;D000086382
|
T005;T067;T047
|
36,298,753
|
brazilian popul aed aegypti resist pyriproxyfen exhibit lower suscept infect zika virus zika virus zikv infect caus devast consequ brazil infect associ neurolog complic neonat aed aegypti primari vector zikv evolut insecticid resist ir speci compromis control effort although relat level phenotyp ir mosquito chang consider time influenc vector compet arbovirus unclear pyriproxyfen ppf resist popul ae aegypti collect five municip locat northeast brazil demonstr differ resist level low serrinha brumado moder juazeiro nort itabuna high quixad experiment per os infect use zikv perform individu popul insecticid suscept strain rockefel determin relat vector compet zikv although popul compet transmit zikv mosquito deriv popul moder high level ir exhibit similar lower suscept zikv infect popul low ir suscept strain observ suggest associ ir arbovirus infect may attribut genet hitchhik use ppf control brazilian ae aegypti may associ indirect benefit reduc suscept infect chang dissemin infect transmiss zikv among ppf resist phenotyp
|
D000071244;D000330;D000071243;D007306
|
T131;T005;T204;T047
|
36,298,752
|
associ midgut bacteria metabol pathway zika infect insecticid resist colombian aed aegypti popul aed aegypti vector sever arbovirus dengu zika chikungunya zika virus zikv outbreak south america associ prenat microcephali guillain barr syndrom mosquito viral transmiss influenc microbiota abund divers interact vector condit cocircul three arbovirus failur vector control due insecticid resist limit dengu manag covid pandem lack effect treatment vaccin make necessari identifi chang mosquito midgut bacteri composit predict function infect studi fundament generat knowledg surveil transmiss risk outbreak diseas local level
|
D000071244;D000071243;D000330;D007306;D000086382;D011722;D001103;D003715;D000890
|
T121;T067;T109;T131;T204;T005;T047
|
36,298,751
|
perform three commerci avail assay detect sar cov antibodi differ time point follow sar cov infect aim studi evalu perform three commerci avail antibodi assay detect sever acut respiratori syndrom coronavirus sar cov antibodi differ time point follow sar cov infect sera case includ sar cov pcr posit test sar cov antibodi wantai receptor bind domain rbd total antibodi assay liaison ss igg assay alin nucleocapsid igg assay compar two step refer elisa sar cov rbd igg sar cov spike igg diagnost sensit specif predict valu cohen kappa calcul commerci assay assay sensit vari great specif remain high three test show good perform sera sampl day pcr posit compar refer elisa total antibodi test perform better igg test first day nucleocapsid igg test show reduc sensit two month pcr posit henc test perform differ time point taken consider clinic practic epidemiolog studi spike rbd igg test prefer sera sampl two month follow sar cov infect
|
D000086382
|
T047;T067
|
36,298,750
|
comparison quantit real time pcr digit pcr detect polyomavirus merkel cell carcinoma merkel cell polyomavirus mcpyv preval merkel cell carcinoma mcc case controversi detect quantif mcpyv dna main perform pcr techniqu use formalin fix paraffin embed ffpe tissu aim studi compar perform two differ molecular techniqu specif quantit real time pcr qpcr digit pcr dpcr sampl case mcc excision surgic biopsi analyz dna extract purif clinic sampl perform use qiacub qiagen autom nucleic acid extractor extract mcpyv detect qpcr dpcr use special design primer probe mcc sampl studi mcpyv genom detect sampl qpcr compar sampl detect dpcr notabl primari tumor posit mcpyv viral genom detect tumor locat uv expos site tumor partial uv protect site tumor uv protect site result show better sensit dpcr detect mcpyv genom mcc sampl compar tradit qpcr techniqu
|
D015266;D011120;D027601;D059965;D012878;D009696;D014412
|
T123;T191;T005;T114;T047
|
36,298,749
|
review omic studi arbovirus alphavirus orthobunyavirus phlebovirus sinc intric complex step pathogenesi host viral interact arthropod born virus arbovirus complet understood multi omic approach encompass proteom transcriptom genom metabolom network analysi great import review omic studi mosquito born virus togavirida peribuyavirida phenuivirida famili specif chikungunya mayaro oropouch rift valley fever virus omic studi potenti provid new perspect pathophysiolog arbovirus contribut better comprehens diseas effect henc provid novel insight develop new antivir drug therapi
|
D001103;D000524;D016851;D016856
|
T005
|
36,298,748
|
investig role african hors sick virus vp protein crystallin particl virus replic releas african hors sick dead high infecti diseas equid caus african hors sick virus ahsv ahsv one econom import member orbivirus genus ahsv transmit bite midg culicoid therefor replic insect mammalian cell type structur protein vp high conserv major core protein orbivirus unlik orbivirus vp ahsv vp high insolubl form flat hexagon crystallin particl unknown function ahsv infect cell express mammalian insect cell examin role ahsv vp virus replic plasmid base revers genet system use generat recombin ahsv form crystallin particl characteris role vp crystallin particl format ahsv replic vitro found solubl vp interact viral protein vp ns similar wild type vp infect interest solubl vp found form uncharacterist tubul like structur infect cell confirm result uniqu vp ns colocalis furthermor found vp crystallin particl play role ahsv releas yield work provid insight role vp aggreg ahsv cellular pathogenesi contribut toward understand possibl effect viral protein aggreg human virus born diseas
|
D000356;D002519
|
T005;T204
|
36,298,747
|
isol genotyp adenovirus wastewat diarrheal sampl egypt human adenovirus hadv preval caus diarrhea children world adenovir infect respons diarrheic case long term investig requir gain better knowledg incid hadv egypt herein conduct year detect isol genotyp hadv fecal sewag sampl cairo egypt use molecular cell cultur assay human adenovirus identifi fecal sampl sewag sampl children age two highest posit rate hadv infect speci f hadv common preval genotyp fecal sewag sampl respect preval genotyp detect fecal sampl hadv hadv hadv hadv contrast common genotyp sewag sampl hadv hadv hadv hadv hadv hadv detect month year peak period clinic sampl decemb februari p lt match egypt raini season month distribut hadv sewag sampl remain consist throughout year statist signific peak period interest hadv type genotyp common genotyp year studi throughout year period work reveal infect rate season distribut virus isol genet divers hadv infect environment clinic sampl cairo egypt non enter adenovirus type well enter adenovirus may play key role gastroenter egypt
|
D000260;D000258
|
T005;T047
|
36,298,746
|
activ host cellular signal mechan enterovirus viral protein associ hand foot mouth diseas enterovirus member picornavirida famili consist human enterovirus group b c well nonhuman enterovirus human enterovirus type ev emerg major caus viral enceph known hand foot mouth diseas hfmd children worldwid especi asia pacif region ev coxsackievirus two virus respons hfmd member group enterovirus identifi ev receptor provid use inform understand viral replic tissu tropism host factor interact intern ribosom entri site ire ev regul viral translat howev specif molecular featur respect viral genom determin virul remain unclear although vaccin current approv effect therapi treat ev infect patient therefor understand host pathogen interact could provid knowledg viral pathogenesi benefit anti viral therapi develop aim studi investig latest find interact viral ligand host receptor well activ immunerel signal pathway innat immun involv differ cytokin chemokin host pathogen interact studi also examin role viral protein main c proteas interferon product inhibitori effect
|
D029821;D004770;D006232;D004769
|
T005;T047
|
36,298,745
|
hiv tat upregul receptor advanc glycat end product superoxid dismutas heart transgen mice cardiovascular disord cvd common comorbid peopl live hiv plwh although under mechan unknown virotox hiv protein tran activ transcript tat like contribut cvd pathogenesi tat express mous myocardium found induc cardiac dysfunct increas marker endotheli toxic howev role tat may play develop cvd pathogenesi unclear capac tat impact cardiac function assess use ac human cardiomyocyt cell adult male femal transgen mice condit express tat tat tat ac cardiomyocyt tat increas intracellular calcium tat mice tat express detect atrial ventricular heart tissu tat mice demonstr increas express receptor advanc glycat end product superoxid dismutas sod ventricular tissu compar tat control chang sod smooth muscl actin observ despit tat mediat chang cellular level chang echocardiograph measur detect tat mice greater proport ventricular mast cell collagen howev doxycyclin exposur offset latter effect data suggest tat exposur promot cellular chang preced progress cvd
|
D015497;D006679;D002318
|
T005;T034;T047
|
36,298,744
|
predict structur function prototyp alphaherpesvirus herp simplex virus type ul tegument protein alphaherpesvirus ul tegument protein high conserv multi function protein mutagenesi analysi delin ul domain necessari retrograd transport viral replic specif amino termin amino acid dispens virus replic epitheli cell cultur unknown whether amino termin delet affect ul structur intracellular transport epitheli cell neuron investig structur function ul util multipl comput approach predict character secondari tertiari structur function featur structur hsv ul n deduc use public avail predict algorithm predict model hsv ul stabl multi function globular monom rich alpha helic unfold region within linker c tail domain high flexibl c tail contain predict bind site dynein intermedi chain well dna rna predict interact cytoplasm surfac lipid membran suggest ul peripher membran protein n truncat alter predict structur ul c terminus protein predict interact dynein valid model examin replic kinet transport n virus toward nuclei infect epitheli neuron cell n virus substanti defect virus spread howev exhibit appar defect virus entri intracellular transport use comput analys identifi sever key featur ul particular flexibl unstructur tail demonstr ul c terminus alon suffici effect transport virus toward nucleus infect epitheli neuron cell
|
D018259
|
T005
|
36,298,743
|
immunogen safeti anti viral efficaci subunit sar cov vaccin candid captiv black foot ferret mustela nigrip suscept viral challeng preliminari vaccin trial emerg pathogen sar cov complet captiv black foot ferret mustela nigrip bff assess safeti immunogen anti viral efficaci vaccin boost bff purifi sar cov subunit protein produc near fold increas mean antibodi titer compar pre vaccin titer serum antibodi respons highest young anim vaccine antibodi respons declin rapid anti viral activ vaccin unvaccin bff determin vitro well vivo passiv serum transfer studi mice transgen mice receiv bff serum transfer subsequ challeng sar cov lung viral load negat correl p lt bff serum titer receiv last experiment challeng studi small group bff complet test suscept sar cov despit viral replic shed upper respiratori tract day post challeng clinic diseas observ either vaccin naiv anim lack morbid mortal observ indic sar cov unlik affect wild bff popul infect captiv anim pose potenti risk albeit low human anim
|
D000086382;D000086663
|
T200;T047;T067
|
36,298,742
|
canari bornavirus orthobornavirus serini infect associ clinic symptom common canari serinus canaria dom parrot bornavirus accept caus proventricular dilat diseas pdd psittacin bird pathogen role bornavirus common canari still unclear answer question whether canari bornavirus speci orthobornavirus serini associ pdd like diseas common canari serinus canaria f dom clinic data canari bird patient test bornavirus use rt pcr assay analyz presenc pdd like gastrointestin central nervous system sign virus main circovirus polyomavirus yeast trichomonad canari bornavirus rna detect clinic sampl canari come flock nucleotid sequenc obtain could unequivoc determin canari bornavirus support current taxonomi speci orthobornavirus serini pdd like sign found associ canari bornavirus detect lesser extent circovirus detect detect polyomavirus yeast trichomonad data indic canari bornavirus contribut pdd like diseas natur infect canari suggest promot effect circovirus develop pdd like sign
|
D028981;D018701;D001715;D010311;D017925;D011120
|
T005;T012;T047
|
36,298,741
|
genet reassort endem introduc macrobrachium rosenbergii nodavirus murray darl basin australia macrobrachium rosenbergii nodavirus mrnv aetiolog agent white tail diseas major limit factor crustacean aquacultur caus mortal rosenbergii larva juvenil despit import mrnv studi phylogenet divers geograph rang virus australian waterway detect mrnv genom common carp cyprinus carpio metatranscriptom sampl five freshwat site across murray darl basin mdb australia identifi genet diverg rna depend rna polymeras gene mrnv sequenc identifi northern southern river mdb northern virus exhibit strong phylogenet cluster mrnv china wherea southern virus close relat mrnv australia howev five virus close relat capsid protein indic genet reassort rna rna segment australian introduc mrnv addit identifi macrobrachium australiens two five mrnv posit librari suggest speci may import reservoir host mdb overal studi report first occurr mrnv outsid queensland region australia provid evid genet reassort endem introduc mrnv
|
D033541;D002347;D030381;D014780
|
T005;T204;T013
|
36,298,740
|
human herpesvirus australia dnaemia cumul exposur blood donor human herpesvirus hhv causat agent kaposi sarcoma multicentr castleman diseas primari effus lymphoma predomin manifest immunocompromis individu howev infect immunocompet individu occur preval hhv exposur blood donor non endem countri rang noth known preval australian blood donor therefor studi investig activ cumul exposur hhv cohort plasma sampl n collect eastern australian blood donor test hhv dna qpcr hhv antibodi two differ elisa sampl initi posit either elisa retest duplic mock coat elisa sampl posit two three three time test least one elisa repeat negat mock coat elisa assign repeat posit none sampl test contain hhv dna serolog test reveal sampl ci antibodi hhv differ p gt seroposit sex increas age first studi show serolog evid cumul hhv exposur hhv dnaemia within select blood donor popul australia molecular serolog data consist publish result blood donor resid hhv non endem countri show preval low
|
D019288;D012514;D005871;D006566
|
T005;T191;T047
|
36,298,739
|
cromilept altiv microrna transcriptom analysi upon nervous necrosi virus nnv infect effect cal mir cell apoptosi virus replic microrna mirna could regul various biolog process nervous necrosi virus nnv one primari germ humpback grouper cromilept altiv commerci fish great import asian aquacultur howev limit avail inform host virus interact c altiv mirna shown play key role host respons infect varieti pathogen better understand regulatori mechan mirna construct mirna transcriptom identifi immun relat mirna c altiv spleen respons nnv infect read three librari map onto danio rerio refer genom result total matur mirna determin known mirna novel mirna among thirti two differenti express mirna demir identifi compar pbs control demir target gene respect use miranda va demir valid qrt pcr show consist obtain high throughput sequenc order studi relationship viral infect host mirna cell line c altiv brain cab use examin express five known demir mir p mir mir mir b p mir nnv infect result show one mirna cal mirna display signific increas express respons virus infect subsequ prove overexpress cal mir enhanc cell apoptosi without nnv infect inhibit virus replic cab cell opposit cal mirna inhibitor mark suppress apoptosi cab cell result apoptosi relat gene mrna express also show regul cal mir apoptosi process cab cell find verifi mir might exert function pro apoptot factor repli nnv stimul cab cell help us studi molecular mechan pathogenesi nnv c altiv
|
D035683;D001492
|
T123;T114;T013
|
36,298,738
|
envelop fusion syncytium format micropl bicoloratus bracovirus matur viral envelop essenti virus matur virus mediat syncytium format induc viral envelop protein caus membran fusion infect cell polydnavirida polydnavirus envelop virus multipl nucleocapsid virion matur symbiot parasitoid wasp ovari howev mechan govern envelop packag multipl nucleocapsid remain unclear studi use transmiss electron microscopi examin process wherebi multipl nucleocapsid micropl bicoloratus bracovirus packag envelop observ envelop fusion syncytium format symbiot wasp calyx cell virus matur virus matur process calyx cell compris four stage pre virogen stroma virogen stroma assembl fusion virus contain singl envelop one nucleocapsid assembl stage multipl envelop fuse form viral envelop multipl nucleocapsid ie envelop fusion syncytium around envelop fusion core fusion stage envelop fusion syncytium stabil virion releas lumen ovari across calyx epitheli layer phagocyt calyx epitheli cell border calyx ovari lumen clear major non envelop nucleocapsid contrast non phagocyt calyx epitheli cell microvilli cuticular line ovari wall lumen remain intact ovari lumen result indic envelop fusion syncytium format import packag multipl nucleocapsid bracovirus matur
|
D018071;D014863
|
T005;T204
|
36,298,737
|
compar upper respiratori tract transcriptom profil reveal potenti role earli activ interferon pathway sever covid infect sar cov result coronavirus diseas covid known caus mild acut respiratori infect sometim progress toward respiratori failur death mechan drive progress diseas accumul high viral load lung without initi symptom remain elus studi evalu upper respiratori tract host transcript respons covid patient mild sever symptom compar control covid negat group use rna sequenc rna seq result reveal upregul earli type interferon respons sever covid patient compar mild negat covid patient moreov sever symptomat patient pronounc induct interferon stimul gene isg particular oligoadenyl synthetas oa famili gene result concurr studi depict earli induct ifn respons sever covid patient provid novel insight isg involv
|
D000086382;D007370
|
T129;T121;T116;T067;T047
|
36,298,736
|
tissu distribut parrot bornavirus pabv experiment infect young adult cockatiel nymphicus hollandicus proventricular dilat diseas pdd caus parrot bornavirus pabv infect often fatal diseas known infect psittaciform impact age time pabv infect organ lesion tissu distribut virus antigen rna remain larg unclear purpos tissu section cockatiel intraven infect pabv adult juvenil respect examin via histolog immunohistochemistri appli phosphoprotein p antibodi direct bornavir phosphoprotein situ hybridis detect viral rna tissu group adult juvenil infect cockatiel widespread tissu distribut bornavir antigen rna well histolog inflammatori lesion demonstr latter appear sever central nervous system adult proventriculus juvenil respect studi central nervous symptom sign gastrointestin affect demonstr adult bird find indic great role age time infect develop histopatholog lesion clinic sign thus provid better understand pathogenesi possibl virus transmiss rout develop carrier bird pose risk psittacin collect
|
D028981;D046410;D010311;D018701;D001715
|
T005;T012;T047
|
36,298,735
|
spatial diffus cherri leaf roll virus reveal bayesian phylodynam analysi cherri leaf roll virus clrv import plant pathogen caus sever detriment effect cherri fruit plant despit recent progress plant patholog molecular biolog popul genet clrv spatiotempor spread virus remain poor studi studi employ bayesian phylodynam framework investig spatial diffus pattern clrv analyz coat protein gene sequenc viral isol collect five differ countri consist trade cherri bayesian phylodynam analys point viral origin new zealand identifi multipl migrat pathway germani countri suggest germani play import role clrv transmiss result studi use develop sustain manag strategi control pathogen
|
D012367;D010935
|
T047;T114
|
36,298,734
|
pin point key hub ifn pathway respond sar cov infect interferon gamma ifn may potenti adjuv immunotherapi covid patient work assess gene express profil associ ifn pathway respons sar cov infect employ case control studi sar cov posit negat patient identifi ifn associ pathway enrich posit patient bioinformat analys show upregul mapk cbl runx stat jak covid posit vs negat patient posit correl observ stat jak vari alongsid patient viral load express mx mx isg oa four well known ifn stimul gene isg display upregul covid posit vs negat patient integr analys showcas higher level isg associ increas viral load stat jak express confirm isg regul perform vitro use lung cell line treat poli c synthet analog viral doubl strand rna differ pulmonari human cell line ferret tracheal biopsi infect sar cov pre clinic murin model coronavirus infect confirm find display increas isg liver lung infect mice altogeth result demonstr role ifn isg respons sar cov infect highlight altern druggabl target boost host respons
|
D000086382
|
T047;T067
|
36,298,733
|
temperatur influenc interact sar cov spike omicron subvari human ace sar cov continu infect million peopl worldwid subvari aris variant concern voc omicron includ ba ba ba ba ba ba possess multipl mutat spike glycoprotein notabl immunogen receptor bind domain rbd present enhanc viral transmiss high mutat spike glycoprotein subvari present differ degre resist recognit cross neutralis plasma previous infect andor vaccin individu recent shown temperatur affect interact spike receptor angiotensin convert enzym ace affin rbd ace signific increas lower temperatur howev whether also observ spike omicron sub lineag known show similar variant spike omicron sub lineag bind better ace receptor lower temperatur whether translat enhanc transmiss fall winter season remain determin
|
D000085962;D000086382
|
T047;T126;T116;T067
|
36,298,732
|
preval genotyp distribut risk factor human papillomavirus tunisia nation base studi limit nation popul base studi hpv genotyp distribut tunisia thus make difficult assess burden vaccin prevent cervic cancer context conduct nation survey determin hpv preval genotyp distribut risk factor hpv infect tunisian women cross section studi perform decemb decemb liquid base pap smear sampl obtain women sampl dnas extract women betaglobin posit pcr analys hpv detect type nest pcr l region follow next generat sequenc multipl logist regress model use analysi associ variabl total women enrol studi cervic sampl posit betaglobin control pcr test hpv overal hpv infect preval measur signific differ grand region rang north grand tuni high risk hpv genotyp account infect preval genotyp hpv hpv detect four case studi popul potenti risk factor live grand tuni region marri status smoke habit occup women multipl sexual partner find underscor need evalu cost effect hpv vaccin implement contribut evid burden hpv infect critic role sexual behaviour socioeconom status call increas support prevent program cervic cancer tunisia
|
D030361;D002583;D052685;D053918
|
T121;T129;T116;T191;T005;T047
|
36,298,731
|
clinicopatholog epidemiolog find pet cat natur infect felin immunodefici virus fiv australia felin immunodefici virus fiv infect experiment infect domest cat produc characterist clinic manifest includ hematolog chang neurolog diseas neoplasia notabl lymphoma lymphopenia mediat immunodefici predispos cat rang secondari infect conflict report exist howev regard diseas associ surviv time natur fiv infect cat purpos retrospect case control studi investig effect natur fiv infect hematolog blood biochem urinalysi paramet surviv time three cohort pet cat australia cohort recruit larg veterinari hospit melbourn victoria n third cohort consist cat recruit around australia part fiv field vaccin efficaci trial n fiv infect cat cohort found clinicopatholog paramet signific differ fiv uninfect cat respect two chang fiv infect cat cohort hypochromia low hemoglobin hyperglobulinemia outsid suppli refer interv serv diagnost trigger fiv test kaplan meier surviv analysi cat cohort combin find differ fiv infect fiv uninfect cat howev confound factor larg euthanasia rate within first month group three signific p lt spatial cluster fiv infect identifi melbourn possibl relationship fiv infect status socioeconom disadvantag discov base three govern indic socioeconom status p lt longitudin field studi perform australia investig long term effect natur fiv infect australian veterinarian consid fiv import infect pet cat recommend measur prevent fiv infect
|
D016181;D016089;D016180
|
T047;T005
|
36,298,730
|
character pathogen two novel prrsvs recombin nadc like nadc like strain china porcin reproduct respiratori syndrom virus prrsvs pose serious threat swine industri china caus great difficulti porcin reproduct respiratori syndrom prrs immun prevent control due easili mutabl recombin natur studi two novel prrsv strain name gd h gd f isol fulli sequenc pig farm guangdong provinc china phylogenet analysi recombin analysi reveal gd h gd f generat recombin nadc like nadc like strain differ previous preval strain pathogen studi piglet sow found recombin strain could caus piglet high fever loss appetit lung lesion piglet die howev recombin strain could caus acut death abort pregnant sow infect model togeth averag surviv rate abort rate respect find indic recombin strain extrem pathogen sow therefor report two clinic novel recombin strain prrsv differ tradit epidem strain china may provid earli warn support prrs immun prevent control
|
D019316;D019318
|
T005;T047
|
36,298,729
|
rna virus pandem anticipatori prepared rna virus like caus futur pandem therefor must creat organ deep knowledg virus prevent manag risk assum prevent fail least must prepar manag futur pandem use resourc avail emphas import safe vaccin candid safe broad spectrum antivir readi rapid clinic translat addit must similar tool readi outbreak rna virus among anim plant final similar coordin accomplish pathogen pandem potenti
|
D012328;D007251
|
T005;T047
|
36,298,728
|
exploit v gene bias rapid high throughput monoclon antibodi isol hors hors human share close relationship includ speci virom mani emerg infecti diseas transmit hors human exhibit mortal rate high popul antibodi biolog repres emerg field rapid discover potent antivir therapeut biolog use provid passiv immun well blueprint ration design novel activ vaccin antigen exploit limit divers immunoglobulin variabl gene use hors develop rapid high throughput monoclon antibodi discoveri pipelin antibodi isol two hors studi develop near exclus high relat germlin gene within singl ighv igv gene famili could recov clone three primer pair variabl gene pair compat hors human immunoglobulin g isotyp confirm suitabl equin antibodi discoveri pipelin develop novel therapeut meet one health approach infecti diseas
|
D001688;D014612
|
T129;T123;T121;T116
|
36,298,727
|
pn pipo protein encod wheat yellow mosaic virus pathogen determin promot pathogen interact nbrlk nicotiana benthamiana similar potyvirid bymovirus wheat yellow mosaic virus wymv encod pn pipo protein express frameshift occur within open read frame p protein pn pipo known essenti cell cell movement sever potyvirus yet confirm wymv show wymv pn pipo protein influenc diseas symptom format infect nicotiana benthamiana plant potato virus x pvx base vector carri wymv pn pipo gene induc sever diseas symptom result higher virus accumul level infect pvx lack pn pipo gene n benthamiana pn pipo interact protein identifi co immunoprecipit co ip coupl lc msms mass spectrometri interact pn pipo n benthamiana receptor like kinas nbrlk verifi co ip bimolecular fluoresc complement bifc transient express protein furthermor investig show diseas symptom sever accumul level pvx pn pipo decreas n benthamiana plant nb rlk express reduc tobacco rattl virus induc gene silenc
|
D017800;D017863
|
T005
|
36,298,726
|
seropreval getah virus pig eastern china determin recombin e protein base indirect elisa getah virus getv genus alphavirus famili togavirida detect throughout world getv caus high morbid mortal newborn piglet entail serious econom loss therefor experiment work getv detect necessari howev due influenc varieti unavoid factor elisa test primari screen anim diseas low accuraci detect result therefor optim recombin e protein base enzym link immunosorb assay elisa detect getv antibodi pig serum e protein success express purifi sds page western blot analysi sera infect pig show strong reaction viral antigen kda correspond e glycoprotein use chessboard titrat compar pn valu found optim concentr coat antigen found gml optim dilut serum specimen best work dilut horseradish peroxidas hrp conjug goat anti pig immunoglobulin igg optim coat condit h c optim incub condit serum specimen block reaction secondari antibodi h c also investig seropreval getv serum specimen collect eastern china sampl test posit anti getv igg antibodi indic seropreval getv high pig popul china seropreval signific lower spring april autumn octob suggest presenc anti getv antibodi pig season conclus improv elisa detect pig antibodi getv experiment natur infect use diagnosi surveil getv infect
|
D000524
|
T005
|
36,298,725
|
develop effect doubl antigen sandwich elisa base p protein detect antibodi african swine fever virus african swine fever asf high lethal swine infecti diseas caus african swine fever virus asfv great threat swine industri effect vaccin diagnost method prevent control diseas current p protein asfv import target serolog diagnosi express earli stage viral replic high immunogen sequenc conservat cpl gene clone express vector pet solubl p protein success express e coli prokaryot express system label horseradish peroxidas hrp enzym label antigen use purifi recombin p protein doubl antigen sandwich elisa asfv antibodi detect develop method exhibit excel specif sensit reproduc clinic sampl detect lower cost shorter product cycl taken togeth studi provid technic support antibodi detect asfv
|
D000358;D000357
|
T005;T047
|
36,298,724
|
novel piggyback strategi mrna deliveri exploit adenovirus entri biolog molecular therapi exploit mrna vector embodi enorm potenti evidenc util technolog context covid pandem nonetheless broad implement promis strategi restrict limit repertoir deliveri vehicl capabl mrna transport basi explor strategi base exploit well character entri biolog adenovirus end studi adenovirus polylysin adpl embodi piggyback transport mrna capsid exterior adenovirus hypothes effici step ad bind receptor mediat entri capsid mediat endosom escap could provid effect pathway transport mrna cellular cytosol transgen express studi confirm adpl could mediat effect gene transfer mrna vector vitro vivo facet method may offer key util actual promis mrna base therapeut
|
D000086382;D000257
|
T047;T067
|
36,298,723
|
first genom evid henipa like virus brazil viral genus henipavirus includ two high virul zoonot virus serious public health concern hendra henipavirus nipah henipavirus outbreak restrict australia southeast asia respect henipavirus genus compris most bat born virus except alreadi describ novel virus rodent shrew reservoir anim america scarc evid support circul virus communic report novel henipa like virus opossum marmosa demerara forest fragment area peix boi municip brazil virus name peix boi virus pbv applic next generat sequenc metagenom approach led us discov origin evid henipa like virus genom brazil south america origin descript henipa like virus marsupi speci find emphas import studi character pbv clarifi ecolog impact public health relationship didelphid marsupi henipavirus
|
D045464;D045404;D045405;D002685
|
T047;T015;T005
|
36,298,722
|
detect new hn high pathogen avian influenza virus winter far east genet close europ mani high pathogen avian influenza hpai case wild bird due hn hpai virus hpaiv infect report northern japan winter investig epidemiolog hpaiv brought japan surround area genet analysi h hpaiv isol northern japan perform pathogen hpaiv chicken assess experiment infect base genet analysi hemagglutinin gene pathogen virus detect northern japan well one sakhalin eastern part russia classifi subgroup virus preval europ season distinct circul asia winter high ident eight segment sequenc acrowhokkaidob hn crowhok repres isol northern japan european isol season could also certifi unlikeli caus gene reassort h hpaiv virus local circul asia accord intranas challeng result six week old chicken chicken lethal dose crowhok calcul time egg infecti dose result demonstr current preval h hpaiv could spread wide certain origin throughout eurasian contin includ europ far east impli possibl contagi virus gather lake northern territori via bird migrat activ monitor wild bird global level essenti estim geograph sourc spread dynam hpaiv
|
D005585;D053124;D009980
|
T047;T005
|
36,298,721
|
interspeci recombin led speciat novel geminivirus pakistan recombin isol differ virus speci known one sourc speciat weed serv mix vessel begomovirus infect wide rang econom import plant therebi facilit recombin chenopodium album econom import weed spread worldwid present molecular character novel recombin begomovirus identifi c album lahor pakistan complet dna genom virus associ leaf distort occur infect c album plant clone sequenc dna sequenc analysi show nucleotid sequenc virus share ident rose leaf curl virus duranta leaf curl virus interest newli identifi virus compos open read frame orf differ origin phylogenet network complementari recombin detect method reveal extens recombin among sequenc infecti clone newli detect virus found fulli infecti c album nicotiana benthamiana viral dna success reconstitut system infect tissu inocul plant thus fulfil koch postul studi reveal new speciat emerg ssdna plant virus associ c album recombin therefor propos tentat name chenopodium leaf distort virus cldv
|
D017791;D053839
|
T005
|
36,298,720
|
epidemiolog analysi cassava mosaic brown streak diseas bemisia tabaci comoro island comprehens assess cassava brown streak diseas cbsd cassava mosaic diseas cmd carri comoro cassava yield tha signific african averag tha larg due virus diseas observ site across comoro island mwali ngazidja ndzwani reveal cassava field foliar symptom cbsd compar cmd molecular diagnost confirm presenc cassava brown streak ipomovirus cbsis cassava mosaic begomovirus cmbs although real time rt pcr detect presenc one cbsi speci cassava brown streak virus cbsv second speci ugandan cassava brown streak virus ucbsv identifi use next generat high throughput sequenc pcr hts detect presenc east african cassava mosaic virus eacmv african cassava mosaic virus detect sampl four whitefli speci identifi sampl specimen bemisia tabaci b afer aleurodicus dispersus paraleyrod bondari cassava b tabaci compris two mitotyp ssa sg ssa sg kasp snp genotyp categor cassava b tabaci haplogroup ssa esa knowledg provid import base develop deploy effect manag strategi cassava virus vector
|
D002365;D006430
|
T204;T002
|
36,298,719
|
develop valid bioinformat workflow rapid detect virus biosecur field biosecur great benefit widespread adopt high throughput sequenc technolog abil deepli queri plant anim sampl pathogen test exist howev bioinformat analysi tool design rapid analysi sequenc dataset develop applic mind limit abil diagnostician standardis workflow use publish tool kit sought assess previous publish bioinformat tool abil identifi plant anim infect virus distinguish host genet materi discov mani current generat virus detect pipelin adequ task outperform generic classif tool creat synthet minion hiseq librari simul plant anim infect econom import virus assess seri tool suitabl rapid accur detect infect test top perform tool viromock challeng dataset ensur find reproduc compar intern standard work demonstr sever method provid sensit specif detect agricultur import virus time manner provid key piec ground truth method develop space
|
D019295;D014780
|
T005;T091
|
36,298,718
|
flavivirus host interact landscap visual genom wide crispr screen flavivirus compris sever import human pathogen caus signific morbid mortal worldwid like virus oblig intracellular parasit therefor studi host cellular factor promot restrict replic pathogenesi becom vital sinc inhibit host depend factor activ host restrict factor suppress viral replic propag cell identifi reveal potenti target antivir therapeut cluster regular interspac short palindrom repeat crispr technolog provid effect mean produc customiz genet modif perform forward genet screen broad spectrum cell type organ eas rapid high reproduc crispr technolog made excel tool carri genom wide screen identifi character viral host depend factor systemat review insight various genom wide crispr screen advanc understand flavivirus host interact
|
D005416;D014780
|
T005
|
36,298,717
|
clinic characterist coronavirus diseas covid mexican children adolesc analyz demograph clinic diagnost data children adolesc mexico first case coronavirus diseas covid februari
|
D000086382;D001249
|
T047;T067
|
36,298,716
|
first polycipivirus unmap rna virus divers yellow crazi ant anoplolepi gracilip yellow crazi ant anoplolepi gracilip widespread invas ant pose signific threat local biodivers yet compar global invas ant speci red import fire ant solenopsi invicta argentin ant linepithema humil littl known divers rna virus yellow crazi ant current studi generat transcriptom databas gracilip use high throughput sequenc approach identifi new rna virus character genom four virus speci assign dicistrovirida two iflavirida one polycipivirida two unclassifi riboviria virus identifi detail genom character carri polycipivirus reveal virus compris nucleotid six open read frame phylogenet analysi pairwis amino acid ident comparison classifi virus genus sopolycivirus polycipivirida tentat name anoplolepi gracilip virus agrv evolutionari analysi show agrv possess high level genet divers elev mutat rate combin common presenc multipl viral strain within singl worker individu suggest agrv like evolv follow quasispeci model subsequ field survey place viral pathogen hotspot gracilip southeast asian region pattern consist region recogn part ant nativ rang last infect multipl virus speci seem preval across field coloni may link ant social organ
|
D001000;D012328
|
T005;T204
|
36,298,715
|
hspjdp requir propag synthet yeast prion yeast prion protein base transmiss element amyloid chaperon protein network yeast inexor link spread prion cell divis fragment amyloid prion aggreg specif core prion fragment machineri includ protein hsp hsp hspj domain protein jdp sis numer novel amyloid form protein creat examin yeast system occasion amyloid also capabl continu hsp depend propag cell popul form synthet prion howev addit chaperon requir determin report first instanc jdp hsp system requir propag synthet prion util construct system engin prion prion form domain prds consist polyq stretch interrupt singl heterolog amino acid interspers everi fifth residu polyqx prds fuse mc domain sup creat chimer protein subset form synthet prion yeast four prion show sis repress caus prion loss manner consist sis known role prion fragment polyqx prion sensit sis express level differ degre congruent variabl observ among nativ prion result expand scope known sis function demonstr sis act amyloid broad rather specif protein protein interact individu yeast prion form protein
|
D011328;D029701
|
T005;T116
|
36,298,714
|
product characteris stabilis pv virus like particl use pichia pastori follow success global vaccin programm use live attenu oral inactiv poliovirus vaccin opv ipv wild poliovirus pv endem afghanistan pakistan howev continu use vaccin pose potenti risk erad pv product recombin pv virus like particl vlps lack viral genom offer great potenti next generat vaccin post polio world previous report product pv vlps use pichia pastori howev vlps non nativ conform c ag would produc effect protect pv build work show possibl produc wt pv thermal stabilis pv refer pv sc vlps nativ conform ag use pichia pastori show pv sc vlps provid much improv c antigen ratio compar wt pv whilst exhibit greater thermost current ipv vaccin final determin cryo em structur yeast deriv pv sc vlps compar previous publish pv ag structur highlight similar recombin express vlps infecti virus emphasis potenti next generat vaccin candid pv
|
D017955;D023321;D011051
|
T129;T121;T109;T005;T047
|
36,298,713
|
adapt mediat transduct lentivir vector novel tool cell type specif gene transfer select gene deliveri cell type interest util target lentivir vector lvs effici safe strategi cell gene therapi applic includ chimer antigen receptor car cell therapi lvs pseudotyp measl virus envelop protein mv lvs retarget ablat bind natur receptor fuse singl chain antibodi specif antigen choic howev broad applic mv lvs hamper labori lv engin requir everi new target report first versatil target system mv lvs sole requir mix biotinyl adapt molecul enabl select gene transfer analysi select mix cell popul reveal transduct effici detect limit absenc adapt fold target ratio flexibl confirm transduc cell line primari cell appli seven differ adapt specif total furthermor adapt mixtur appli generat car cell vari cdcd ratio singl transduct step summari select flexibl target system establish may serv improv safeti efficaci cellular therapi compat wide rang readili avail biotinyl molecul provid ideal technolog varieti applic
|
D016086;D000076962
|
T129;T005;T116;T192
|
36,298,712
|
pathogen la jolla virus drosophila suzukii follow oral administr drosophila suzukii ds invas pest insect caus sever widespread damag soft fruit crop chemic control base topic insecticid ineffici harm consum environ prompt interest develop biolog control measur insect virus narrow host specif previous describ strain la jolla virus ljv found moribund ds specimen germani demonstr pathogen effect follow intrathorac inject ljv adult ds fli howev develop effect biocontrol product base ljv would requir character virul follow oral deliveri particular larva stabil differ ph temperatur condit reflect realist exposur scenario describ pathogen ljv follow oral deliveri ds adult larva oral infect ds adult ljv reduc surviv concentr depend manner wherea oral infect ds larva caus arrest develop pupat ljv remain stabl infecti follow exposur broad ph rang differ temperatur therefor demonstr ljv promis candid biolog control agent ds
|
D007306;D012328
|
T131;T005
|
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